TW436291B - Topical compositions containing N-acetylcysteine and odor masking materials - Google Patents

Abstract

Disclosed are topical compositions comprising from about 0.01% to about 50% by weight of N-acetylcysteine or related compounds, from about 0.01% to about 0.5% by weight of selected combinations of certain perfume chemicals to effectively mask malodors associated with topical application of the N-acetylcysteine or related compounds on skin; and a cosmetically acceptable topical carrier. These topical compositions are useful for visibly improving the appearance of skin.

Description

^ 436291 V. Description of the invention (1) Field of the invention The present invention relates to a topical composition containing a selective combination of N-acetamidine cysteine or related compounds, and a specific perfume chemical as an odor shield. BACKGROUND OF THE INVENTION Many personal care products currently available to consumers are related to improving the health and / or physical appearance of the skin. Many of these skin care products are about delaying, reducing or even excluding skin wrinkles and other tissue changes that accompany the natural aging of human skin. Human skin is abused for many external and internal factors. External factors include ultraviolet radiation, low humidity, rough shuttle surfactants, friction, etc. Internal factors include ageing and other biochemical changes from the skin. The aging process especially caused Pi Guang's unique and general degradation. When the skin naturally ages, the cells and blood vessels that supply the skin are reduced, and the skin-epidermal junction is flattened, which results in weaker mechanical resistance to this junction. Regardless of external or internal ’these abuse factors often cause unintended wrinkles and other organizational changes. Various products have been developed in an attempt to reduce or eliminate wrinkles and other tissue changes associated with aging or exposure to various rough external factors. Examples of this product include humectants containing N-acetamidine and 'topical formulations, Retinoids (eg, retinoic acid), alpha-hydroxy acids (eg, glycolic acid 'lactic acid), and / or other similar substances. Although topical products containing N. acetamidine cysteine are particularly effective for this purpose, their use has been limited. In the preparation, packaging and storage of these products, a paper size applies to the Chinese national standard (CNS > Α4 size (210X297 mm) -------- &.; clothing! · F (please listen first Read the precautions on the back and fill in this page again.) Order the male laborer ’s consumer cooperation agreement with the Central Bureau of the Ministry of Economic Affairs, printed A7 Β7 43629 V. Description of the invention (2) Some N-acetamidine cysteine is generally degraded into and releases malodor. Thiols and hydrogen sulfide. The formation of these malodorous compounds therefore limits the use of topical compositions containing N-acetamidine, especially when attempts are made to reduce or eliminate these malodors when the composition is intended for facial applications Includes the use of various fragrances and fragrances' and the use of various clamps, such as zinc salts. However, most fragrances are not suitable for covering the malodor accompanying these topical products. Although the overall feeling impression of these aromatherapy prescriptions has changed, but still Maintains the unique and undesired stench caused by N_ acetamidine and its mercaptans and hydrogen sulfide degradation products. It has now been found that 'Once these topical products are applied to the skin, even with the use of conventional facial control For example, zinc is not able to properly control the sweeteners such as odor bromide9. These sweeteners reduce the malodor generated from the packaging composition. Therefore, before being applied to Piguang, the malodor is reduced in the package and the composition itself. However, once the composition is applied to the skin, the malodor is essentially stubborn. In addition, the applicant has discovered that neither conventional fragrances nor conventional clamps properly exclude or cover the topical application of the composition to human skin These enhanced flavors are caused later. The applicant has discovered that when a selected combination of specific fragrance chemicals is added to the N-acetamidine cysteine composition, it effectively covers the topical application of this composition on human skin The stubborn stench produced ^ · Even so, there is a continuing need to provide a topical composition containing N • acetamidine, which emits an acceptable taste, especially when applied topically. It is therefore an object of the present invention to provide this Composition, in particular to provide a topical composition containing N-acetamidine, which has an acceptable level before and after application to the skin Standard (CNS) Α4 specification (210X297 mm) -------------'(Please read the precautions on the back before filling out this page) Ordered by the Central Bureau of Standards, Ministry of Economic Affairs and Consumer Cooperatives Printed by the Central Bureau of Standards of the Ministry of Economic Affairs and Consumers Cooperatives-) 4362 91 V. Description of the invention (3) 疋 Taste, more specifically this composition containing effective odor shield substances 0 Summary of the invention The present invention relates to local combinations A substance comprising about 0.001% to about 50% by weight selected from the group consisting of N-acetamidine cysteine, a derivative of N-acetamidine cysteine, and N-acetamidine cysteine A pharmaceutically acceptable salt, a pharmaceutically acceptable salt of a derivative of N-6 cysteine, and a compound of a mixture thereof; an odor masking substance of about 0.01% to about 0.5% by weight, which is selected to cover the skin Malodor 'and topical carriers accompanied by topical application of the compound. The odorant protective substance sequentially comprises a combination of the following fragrance chemicals: (i) about 35% to about 95 ° /. A weight ratio of a pentaester, an aliphatic ester, or a mixture thereof 'has an average molecular weight of about 120 to about 205; (u) about 4 ° /. To about 60. /. Aromatic alcohols, aliphatic alcohols or mixtures thereof in a weight ratio have an average molecular weight of about 110 to about 180; (iii) about 0.05 ° /. To about 20% by weight of an aliphatic ketone having an average molecular weight of less than about 210; (iv) about 0.1% to about 20% by weight of an aromatic aldehyde, an aliphatic hydrazone or a mixture thereof 'which has about 100 to about An average molecular weight of 225; (v) not more than about 20% by weight selected from perfume chemicals including aromatic ethers, aliphatic ethers, aromatic esters, or mixtures thereof, having an average molecular weight of at least about 210; DETAILED DESCRIPTION The topical composition of the present invention comprises a selected combination of N-acetamidine and specific perfume chemicals, all of which are added to a cosmetically acceptable carrier. These combinations-6-This paper size applies to China National Standards (CNS) from% > cells (210 乂 297 mm) (^^ 1 In I--if-I-II ^ n I r ·· {Please (Please read the notes on the back before filling this page)-Order the consumer cooperation of the Central Bureau of the Ministry of Economic Affairs. Printed by the society ^ 436291 at ____B7__ V. Description of the invention (4) The thing is preferably a licensed prescription 'and can be used for processing and Clearly improve the appearance of human skin. The composition of the present invention may include, include, or essentially include, the main and optional ingredients described herein. All parts, percentages, and ratios used herein are based on the weight of the Quan Zhao composition, and all measurements are made at 25 eC unless otherwise indicated. All weight percentages are based on effective weight unless otherwise indicated. As used herein, "topical application" means applying or dispersing the composition of the present invention to the surface of human skin. "Cosmetically and / or pharmaceutically acceptable" as used herein refers to substances suitable for use in contact with human and lower animal tissues without undue toxicity, incompatibility, instability, allergic reactions, etc. As used herein, " treating and significantly improving the appearance of human skin " means that the composition of the present invention can be used for topical application and provides, for example, improving signs of skin aging, improving skin texture, reducing porosity, and / or The spots that are too dark provide the benefits of skin lightening, etc. "Symptoms of skin aging 11" as used herein refers to externally visible and tactile displays, all internal displays, and any other large or small effects. For example "The term" skin aging "as used herein includes processes induced or caused by external or internal factors. These conditions include, but are not limited to, the occurrence of wrinkles, including fine surface wrinkles and thick and sensitive skin lines, skin lines, sagging, Discoloration, age spots, keratin, hyperkeratosis, degeneration of elastic tissues, collagen rupture 'and in the stratum corneum, palate, epidermis, vascular system, and palate Changes in other organizations of this organization》 This paper size applies to Chinese National Standard (CNS). A4 ^ t grid (20.1 × 297 mm) --------- clothing-* spring (please read first Note on the back, please fill in this purchase again) Order printed by S Industry Consumer Cooperative of Central Bureau of Standards of the Ministry of Economic Affairs ^ 3 6 2 9 Ί Α7 ____; __Β7 V. Description of the invention (5) Unless otherwise instructed, the Brewery used here "Carnitine" includes ν · ethynylcysteine, N-ethoxyl-L-cysteine, N-ethynyl-D-fungamine ', a pharmaceutically acceptable derivative thereof, and a pharmacologically acceptable derivative thereof. Acceptable salts and their compounds. N-Acetylcysteine The composition of the present invention comprises a member selected from the group consisting of N-acetamylcysteine, N-ethanyl-L-cysteine, N-acetamyl-D-cysteine The compound of the amino acid, its pharmaceutically acceptable derivative, its pharmaceutically acceptable salt ', and mixtures thereof is preferably N-acetamido-L-cysteine. The concentration of these compounds ranges from about 0% to about 50% of the composition, more preferably from about 0.1% to about 0%, and most preferably from about 0.25% to about 5% by weight. -N-acetamidine hemamic acid can be represented by the following chemical structure: un 0 C = 0

II I

CH3—C-NH-CH-CH2—SH N-Ethyl cysteine is an "acetylated" derivative of the amino acid cysteine. Cysteine, and more complex than glycine All amino acid complexes exist in two mirror-isomeric forms, the naturally occurring " L " form and its non-naturally occurring 'D " form, the form of N-ethanoic acid, called N -Ethyl-L-cysteine, which is better to use here, because it is easier to obtain, although it can also be used in "IT form", it should also be understood that hemi-deaminic acid and its N-ethylated derivatives It can exist as an oxidized dimer, however, the monomeric form of N-acetamidinecysteine is preferably used here. Derivatives of N-acetamidinecysteine can also be used here. These derivatives include -8- This paper uses Chinese National Standards (CMS) A4 specifications (21 × 297 mm) (Please read the notes on the back before filling this page) 袈

I? J "436291_B7 __ 5. Description of the invention (6) Non-limiting examples of thioester and thioether β derivatives including esters, amidines, anhydrides, and thiol moieties include: N-acetamidine cysteamine Methyl ester, N-ethyl ethyl cysteine, N-ethyl stearyl cysteine, N-ethyl cysteine methyl sulfide, N, S-diethyl cysteamine Acid, N-ethylcysteamine, and mixed anhydrides of N-ethylcysteine and acetic acid. Pharmaceutically acceptable salts of N-acetamcysteine and N- Salts of acetocysteine derivatives. Non-limiting examples of these salts include: sodium, potassium, magnesium, calcium, zinc, ammonium, alkylammonium, and alkanolammonium salts, among which ammonium ions Substituted by one or more alkyl or alkanol moieties. N-Acetylcysteine and related compounds, salts and derivatives suitable for use in this composition are described in The Merck Indix, Tenth Edition, entry 82, page 13 '(1983); and U.S. Patent 5,296,500; this description is incorporated herein by reference. Odour shield substances The composition of the present invention comprises an odor shield substance which contains specific perfume chemicals Select a combination. The concentration of the odor shield is in the range of about 0.01% to about 0.5% of the composition, preferably about 0.02% to about 0.3%, and more preferably about 0.03% to about 0.2% by weight. Odor The cover material contains the following combinations of perfume chemicals: Printed by the Central Government Bureau of the Ministry of Economic Affairs, Shellfish Consumer Cooperatives -------- (. 策-* r (Please read the notes on the back before filling out this (A) from about 35% to about 95%, preferably from about 40% to about 85% by weight of an aromatic ester, an aliphatic compound, or a mixture thereof having about 120 to about 205, preferably about 150 To an average molecular weight of about 200; (b) from 4% to about 60%, preferably from about 10% to about 50% by weight of an aromatic alcohol, an aliphatic alcohol, or a mixture thereof, having about u0 to about 18〇, preferably u 436291 A7 _______B7 V. Description of the invention (7) is an average molecular weight of about 120 to about 160; (c) about 0.005 ° / ❶ to about 20 ° /., preferably The aliphatic fluorene 'having a weight ratio of about 0.001% to about 15% has an average molecular weight of less than about 2100', preferably about 260 to about 200; (d) from about to about 20%, preferably About 0.02% to about 15% by weight of aromatic while 'aliphatic or The mixture has an average molecular weight of about 100 to about 225, preferably about 130 to about 220; (e) less than about 20%, preferably less than about 10%, more preferably less than about 5 The weight ratio of 〇 / 〇 is selected from perfume chemicals including aromatic ethers, aliphatic ethers, aromatic esters, or mixtures thereof, which have an average molecular weight of at least about 21.0. One of the odor shield materials used in the composition Specified examples of suitable and better flavor chemicals include the following: (Please read the notes on the back before filling out this page.) The Ministry of Economic Affairs, Central Bureau of Standards and Technology, Consumer Cooperation, Du Yinzhuang, commonly known as the chemical type and chemical name, is approximately MW adoxal aliphatic Aldehyde 2,6,10-trimethyl-9 --- pyridin-1-yl 210 amyl acetate g 3-pentyl-1-butyryl acetate Ϊ 30 anise 趑 aromatic aldehyde methoxy benzene 曱 chain 136 benzene Formaldehyde groupings-106 ethyl acetate acetate " ETZWsi 150 ethyl acetate butyrate τΈΨΈ--178 ethyl acetate propionate benzyl propionate, 164 cold argon damascone aliphatic ketone 1- (2,6 , 6-Dimethyl storm-1-cyclohexyl-1-yl) -2-butan-1-fluorene192 cis-3-hexenyl salicylate salicylic acid, r-associate 220 lemongrass Alcohol 3,7-monomethyl-6-octanol 156 Citronella acetate 3,7 · dimethyl-6 · octane -1 vinegar 198 -10- This paper size applies to Chinese national standards ( CNS) A4 specification (2! OX297 mm) y 43629 1 V. Description of the invention (s) Employees ’Cooperative of the Central Bureau of Standards of the Ministry of Economic Affairs of India Citronellene 3,7-difluorenyl-2,6-octadiene Nitrile 151 cymal aromatic aldehyde 2-fluorenyl-3- (cis-isopropylphenyl) propanal 190 decyl aldehyde aliphatic aldehyde decanoal 156 < 5 " dimuratine aliphatic ketone 1- (2,6 , 6-trimethyl-3-cyclohexyl-1 -yl) -2. Butan-1-嗣 192 dihydrolauryl enol 3-methylene-7-fluorenyloct-7-ol 156 Ethyl vanillin aromatic acid ethyl vanillin 166 florhydral aromatic aldehyde 3- (3-isopropylphenyl) butyraldehyde 190 geraniol 3,7-difluorenyl-2,6-octadiene -1-ol 154 geranyl acetate 3,7-dimethyl-2,6-octane diacetate-1-vinegar 196 geranyl formate cis 3,7-dimethyl-2 1,6-octadiene ester 182 geranylnitrile ester 3,7-dimethyl-2,6-octanediocyanonitrile 149 helional aromatic aldehyde α-methyl-3,4- (methyldioxy) hydrocinnamate 192 Xiang Yue Huaxiang Road Aromatic Aldehyde Xianghuahuayue 150 Hexyl Guipitz Aromatics while ττ-n-hexyl cinnamic acid 216 Hydroxycitronellal Aromatic acid Hydroxycitronellal 172 Purpurone α Aliphatic Ketone 4- (2,6,6- Trimethyl-1-cyclohexyl-1-yl) 3-butadiene-2. 嗣 192 Shionone nonaliphatic ketone 4- (2,6,6-trimethyl-1-cyclohexene-1 -Yl) -3-buten-2-one 192 koavone aliphatic aldehyde acetamidinyl diisopentyl 182 lauryl aliphatic sulfonyl laurate 184 oudyl acetate 3-hydroxy-3,7-dimethyl- 1,6-octadiene acetate 196 Agarum butyrate Agarum n-butyrate 224 Agarum propionate Acetate 3,7-dimethyl-1,6-octadiene-3-ester 210- 11-This paper scale is applicable to the Chinese National Standard (CNS) A4 specification (210X297 mm) --------- f policy ------ order ------ η * t (please first Read the notes on the back and fill out this page) 9 2 6 3 4%

7 7 AB V. Description of the invention (9) Neobell blue aldehyde aliphatic aldehyde 4- (4-hydroxy-4-methylpentyl) -3-cyclohexene-1-carboxaldehyde 210 methyl anthranilate Methyl 2-aminobenzoate 151 methylnonylacetaldehyde aliphatic fluorene methylnonylacetaldehyde 184 PT bucinal aromatic aldehyde 2-methyl-3- (cis-tert-butylphenyl) propanal 204 Acetoaldehyde Aromatic Aldehyde1 · Carbonoxy-2-Phenyl Acetate 120 Phenylacetamidodimethyl Carboxaldehyde Aromatic Acetyl Acetaldehyde Dimethyl Carboxaldehyde 166 Phenyl Ethyl Acetate Phenyl Acetate Ethyl 164 Phenylethanol alcohol Phenyl alcohol 122 Isoprenyl acetate 2-methylbuten-2-ol-4-acetate 128 Methyl alcohol Methyl alcohol and pinanol -Meng-1-asso-8-alcohol 'cis · Meng · 1_en-1-ol 154 j--Knee aliphatic aldehyde--Take a 170 Η-- 晞 While aliphatic aldehyde-)-Take 168 vanillin aromatic Group aldehyde 4-hydroxy-3-methoxybenzaldehyde 152 verdox ester cyclohexyl acetate 2-tert-butyl ester 198 vertenex ester cyclohexyl acetate 4-tert-butyl ester 198 (Please read the precautions on the back before filling in this (Page) Printed by the Central Standard of the Ministry of Economic Affairs, Gengeng Consumer Cooperatives After the flavor substance is applied to the protective cover on the composition of human skin, effectively protecting cover or cap malodor associated local N- acetyl-cysteine of the composition. Although these malodors are mainly caused by volatile thiols and hydrogen sulfide degradation products found in the composition, it is not fully understood whether this thiol or hydrogen sulfide odor is enhanced or generated after application to the skin. It has also been found that the odor shield substances described herein remain on the skin for an effective amount of time or the amount of time the malodor emitted by the topical application of the N-acetylcysteine: amino acid composition is maintained. Odor-masking substances also serve as "olfactory signals" in the form of favorite odors, which serve as a signal to mask malodor on the skin. Many commonly used fragrance substances for personal care products have been found in -12- Applicable to China National Standard (CNS) A4 specification (2f〇297mm) Printed by A7 4-3 62 91 of the Ministry of Economic Affairs, Central Labor Bureau, Consumer Cooperatives _ 耵 _ V. Description of the invention (10) The composition is applied to the skin Provides little or no odor military benefits. Examples of this ineffective perfume substance include aromatic ketones, aromatic and aliphatic ethers, and lactones, all of which have a molecular weight greater than about 210 and aromatics with a molecular weight greater than about 21 Groups and aliphatic esters. Examples of this ineffective perfume substance include tridecyl ethylene glycol, cyclopentadecanone, methyl dihydrojasmonate, Jiaya elk, tuna musk / multi-musk, musk indanone, And benzyl salicylate ^ The concentration of these ineffective perfume materials in the composition is preferably at least or avoided together, but this material must not exceed about 10% of the composition, preferably not more than about 5% by weight. Vehicle of the invention The composition contains a cosmetically acceptable topical carrier, to which N-acetamidine and odor masking substances are added. The concentration of the topical carrier can vary with the selected carrier and the main and optional ingredients The intended concentration varies depending on the intended concentration. Suitable topical carriers for use in the composition include conventional or known carriers that are pharmaceutically acceptable for application to human skin. Topical carriers should also be physically compatible with the main ingredients described herein. And chemically compatible, or should not unduly impair aesthetics, odor masking properties, or other use benefits that accompany the composition of the present invention. Preferred topical carriers include, for example, oil-in-water emulsions, water-in-oil emulsions, and polymenox Water-in-emulsion emulsion system, in which substantially all of the N. acetamidine cysteine is distributed into the water phase, and substantially the odor-shielding substance is distributed to the hydrophobic or insoluble water phase. A preferred topical carrier The detailed description is as follows. The most suitable local carrier for the polysilicone water-in-roll rolling suitable continuous polysilicon argon phase for the composition of the present invention is the polysilicone water-in-water emulsion. ) A4 specifications (210X297 Mm) ---------- C wood — A * (Please read the notes on the back before filling in this page)

1. 1T printed by the Central Laboratories of the Ministry of Economic Affairs Real Consumer Cooperatives r A3 9 '_b7____ 5. Description of the invention (U) It contains about 1¼ to about 60% of the local carrier, preferably about 5% to about 40%, More preferably, the continuous polysiloxane phase is from about 10% to about 20% by weight. As used herein, " liquid " refers to a substance having a melting point of about 25 ° C or lower under a pressure of about 1 atmosphere. Liquid organic polysiloxanes can be selected from a wide variety of polysiloxanes that span a wide range of volatility and viscosity. Examples of organic polysiloxanes include polysilylsiloxanes, cyclic polyalkylsiloxanes, and Polyalkylarylsiloxanes that can be used herein include, for example, polyalkylsiloxanes having a viscosity of about 0.5 to about 1,000,000 centipoise at 25eC. This polyalkyl oxyoxane corresponds to the general formula R3SiO [R2SiO] xSiR3, where R is

Alkyl groups (preferably, R is methyl or ethyl, more preferably methyl; the same molecule can also use a mixed fluorenyl group), and X is 0 to about 〇〇〇〇〇〇〇 The integer number is selected to obtain the desired molecular weight, with a range of more than about 10,000,000 Λ. Commercially available polyalkylsiloxanes include polydimethylsiloxane, which is also known as dimethylpolysiloxane, which Non-limiting examples include Vicasil® series sold by General Electronics and Dow Corning® 200 series β sold by Dow Corning. Specified examples of polydimethylsiloxanes that can be used herein include viscosity with 0.65 centipoise and 100 ° C. Dow Corning® 200 fluid with a boiling point, Dow Corning® 225 fluid with a boiling point of 10 centipoise and a Dow Corning® 225 fluid with a boiling point of more than 20 ° C, and Dow with a viscosity of 50, 350, and 12,500 centipoise each and a boiling point greater than 200 eC Corning® 200 fluid. Dimethicone with pendant alkyl ranging from C2 to about C30 can also be used. These materials can be represented by the formula (CH3) 3SiO [(CH3) 2SiO] x [CH3RSiO] ySi (CH3 ) 3, wherein R is a straight or branched chain having two to about 30 carbon atoms, and X and y are each 1 or _____- 14 -___ This paper size applies to China National Standard (CNS) A4 (210X297 mm) (Please read the note on the back before filling this page)-Order A7 B7 ^ 43629 ^ V. Description of the invention (12 For larger integers, choose to get the desired molecular weight, the range is more than about (please read the notes on the back first, fill in this page) 10.0, 0, 0, 0. These alkyl-substituted dimethyl polysilicon Examples of oxyalkanes include hexadecyl dimethyl polyoxymethylene and lauryl dimethyl polyoxofluorene. Cyclic polyalkylsiloxanes that can be used herein include the corresponding chemical formula 'where R is an alkyl group (preferably R is fluorenyl or ethyl, more preferably methyl), and η is an integer of about 3 to about 8, more preferably 11 is an integer of about 3 to about 7, and most preferably ϋ is about 4 to An integer of about 6. When R is a methyl group, these materials are generally referred to as cyclomethicone. Commercially available cyclofluorene polysiloxane includes a viscosity of 2.5 centipoise and 172. (: boiling point of 〇 〇 Comment (:: () & 11§) 6) 244 fluid, which mainly contains cyclomethicone tetramer (ie, η = 4), has a viscosity of 2.5 centipoise and a point of 178C Dow Corning® 3 44 fluid, which mainly contains cyclopentamidine pentamer (ie, n = 5), Dow Corning® 245 fluid with a viscosity of 4.2 centipoise and a stagnation point of 205 C, which is mainly a ring A mixture of tetramer and pentamer of Jiajumengoxi 1 (ie, n = 4 and 5), and Dow Corning® 3 45 Liu Zhao with a viscosity of 4.5 centipoise and a Buddha of 217C, which mainly contains ring曱 Polysiloxane tetramers, pentamers, and mixtures of hexamers (ie, 'n = 4, 5, and 6) »Can also be used as substances such as trimethylmonosiloxy silicate' It is a polymer substance corresponding to the general chemical formula [(CH2) 3Si01 / 2] x [Si02] y, printed by the Consumers' Cooperative of the Central Standards Bureau of the Ministry of Economic Affairs, where X is an integer of about 1 to about 500, and y is about 1 Up to an integer of about 500 "Commercially available trimethylcarsiloxy silicates are burned with dimethylpolyoxysilane; they are marketed, such as Dow Corning® 593 Liu Zhao.

Also useful herein is dimethyl polysiloxane, which is a dimethyl polysiloxane terminated with a hydroxyl group. These substances can be of the general formula R3SiO [R2SiO] xSiR2OH 15 The paper size is applicable to the Chinese National Standard (CNS) A4 (210X297 mm) ^ 436291 Printed by the Shellfish Consumer Cooperative of the Central Bureau of Standards of the Ministry of Economy (13) and HOR2SiO [R2SiO] xSiR2OH represents that R is an alkyl group (preferably, R is a methyl group or an ethyl group, and more preferably a fluorenyl group), and X is an integer of 0 to about 500, which is selected to obtain the Required molecular weight. Commercially available dimethyl polysiloxanes are typically sold as mixtures with dimethyl polysiloxane or cyclomethicone (eg, Dow Corning® 1401, 1402, and 1403 fluids). Polyalkylarylsiloxanes can also be used here, and polyfluorenylphenylsiloxanes having a viscosity of about 15 to about 65 centipoise at 25eC are preferred. For example, these materials are obtained from SF 1075 fluorenyl phenyl fluid (sold by General Electronics) and 556 cosmetic-grade phenyltrimethicone fluid (sold by Dow Corning). It is preferably used here selected from the group consisting of polyalkylsiloxanes, alkyl-substituted dimethylpolysiloxanes, cyclofluorene polysiloxanes, trimethylmono > alkyl silicates, dimethyl polystearyl alcohol ' Polyalkylarylsiloxanes, and organic polysiloxanes of mixtures thereof. More preferably used here are polyalkylsiloxanes and cyclomethicone. Among polyalkylsiloxanes, difluorinated polysiloxane is preferred. The water-dispersed polysiloxane emulsion preferably contains from about 30% to about 90% of a topical carrier, preferably from about 50% to about 85%, most preferably from about 70% to about 80%. % By weight of the dispersed aqueous phase. In emulsion technology, the term " dispersed phase " is a term known to those skilled in the art ' which means that a phase exists as small particles or drops suspended in a continuous phase and surrounded. The dispersed phase is also known as the internal or discontinuous phase β. As described above, substantially all of the N-acetamidine cysteine is distributed into the dispersed aqueous phase. Other water-soluble or dispersing substances can also be added to the dispersed aqueous phase β. See to disperse the emulsified phase. The preferred water-in-silicone emulsion contains about 0 i 0 /. To the order, preferably about _ ~ 16-(Please read the notes on the back before filling out this page) Binding-order the paper size General China National Standards (CNS) A4 size (2ι〇χ29? Mm economy Printed by the Ministry of Health, the Zhuhai Bureau Shellfish Consumer Cooperative ^ 436291 Α7 _ B7 V. Description of the invention (14) 0.5% to about 7.5% 'more preferably about 1% to about 5. Emulsifiers, will not The continuous aqueous phase is dispersed into the continuous polysiloxane phase (% by weight of the topical carrier). A wide variety of emulsifiers can be used here to form a better polysiloxane water-in-oil emulsion. Mixtures of emulsifiers are also available. These emulsifiers include those selected from the group consisting of silicone emulsifiers, silicone-free emulsifiers, and mixtures thereof. It is preferred that these emulsifiers have less than about 14, more preferably about 2 to about 4, and most preferably HLB of about 4 to about 14. It has been found that if other emulsifiers are combined, emulsifiers with HLB (R) outside these ranges can be used so that the combination knows an effective weight average Hlb within the range described in the previous sentence Abbreviation. "&Quot; HLB " means hydrophilic and lipophilic balance. The HLB system is It is known to this artist 'and is described in detail in the "iLB system, a time-saving guide for the selection of emulsifiers" "American ICI Corporation, August 1984, all of which are incorporated herein by reference. It can be widely used here Kinds of polysiloxane emulsifiers. These polysiloxane emulsifiers are generally organic modified organic polysiloxanes. These materials are also known to those skilled in the art such as polysiloxane surfactants. Polysiloxane emulsifiers are available Agents include dimethyl polysiloxane copolymers. These materials are polyether side chains that have been modified to include, for example, polyoxyethylene chains 'polyoxypropylene chains', and polyether side chains derived from ethylene oxide and propylene oxide. Other examples of polydimethylsteaxane in the acid-bond portion include alkyl modified bis-polysiloxane copolymers, that is, compounds containing pendant C2-C30 pendant side bonds. Other useful dimethyl polycopolymers Alcohol includes substances with various cationic, anionic, amphoteric and zwitterionic pendant parts.> These dimethyl polysilicon copolyols which can be used here are as follows;-general structure-17- This paper is applicable to China standard CNS) M specifications (210X297 mm) (please read the notes on the back before filling in this 1) -Γ 袈, -ιτ 43629 1. A7 B7 5. Description of the invention (15): ch3 I CHj-Si- 〇I- CH3 CH3 ch3 CHj -Si——0 " Si--〇j --SH " 0 ch3 IR R2-X • _ y J CHj I -Si—CH3 I ch3 Shellfish consumption by the Central Standards Bureau of the Ministry of Economic Affairs Cooperatives are printed where II is C1-C30 straight, branched, or cyclic alkyl, and R2 is selected from the following: (CH2) n-〇- (CH2CHR30) mH, and '(CH2) n-〇 .- (CH2CHR3O) m -(CH2CHR4O) 0-H! Wherein η is an integer from 3 to about 10, and R3 and trans 4 are selected from the group consisting of straight and branched alkyl groups including η and C1-C6, so that R3 and R4 are not the same at the same time; and m 'is selected; 〇, X, and y make the molecule have a total molecular weight of about 200 to about 100,000, 000,000, and m, 0, X, and y are independently selected from integers of zero or greater, so that 111 and 0 is not zero at the same time and z is independently selected from the integer β of 1 or more. It is understood that positional isomers of these co-alcohols are available. The above chemical representations of the R2 moiety containing the R3 and R4 groups are not meant to be limiting, and are shown for convenience only. Although it is not strictly classified as dimethyl polysiloxane copolyol, the polysiloxane surfactant described in the structure of the previous paragraph can also be used, where R2 is:-(CH2) n..〇-R5 >, where R5 is a cationic, anionic, amphoteric, or zwitterionic moiety. Non-limiting examples of dimethylpolysiloxane copolyols and other polysiloxane surfactants which can be used as emulsifiers include dangling polyfluorinated ethylene. Side chain of -18- owing paper ill Ashiko jJL with solid solid B0 Tangbian / rXTC, A yliB 4 * /,. Λ, > w »., At \---[------- ---- (Installation — 'Qin (please read the precautions on the back before filling out this page) ΐ 43629 i Α7 · * A 7 _______ Β7_ V. Description of the invention (16) Printed by the Central Standards Bureau of the Ministry of Economic Affairs and Consumer Cooperatives ( (Please read the precautions on the back before filling out this page) Polydimethylsiloxane polyether copolymer, Polydimethylsiloxane polyether copolymer with pendant poly (propylene oxide) side chains, Mixed polyoxysilane with pendant Polydimethylsiloxane polyether copolymer with side chains of ethylene and polyoxypropylene, with pendant mixed polyoxyethylene (ethylene) (propylene Polydimethylsiloxane polyether copolymer with side chains, polydimethylsiloxane polyether copolymer with pendant organic internal salt side chains, polydimethylsiloxane with pendant carboxylate side chains Polyether copolymers, polydimethylsiloxane polyether copolymers with pendant quaternary ammonium side chains; and further modifications of the above copolymers containing pendant C2-C30 straight, branched, or cyclic alkyl moieties Commercially available dimethyl polysiloxane copolymers sold by Dow Corning Corporation for use herein are Dow Corning® 190, 193, Q2-5220, 2501 waxes, 2-5324 fluids, and 3225C (the latter substances such as Hexadecyl dimethyl polysiloxane copolymers sold as mixtures of methyl polysiloxanes such as mixtures with polyglyceryl-4-isostearate (and) hexyl laurate are commercially available under the trademark Sold under the name ABIL® WE-09 (available from Goldschmidt). Hexadecyl difluorenyl polysiloxane is also known as hexyl laurate (and) polyglyceryl-3 oleate (and) cetyl Blends of dimethyl polysiloxane are commercially known 'and are sold under the trade name ABIL® WE-08 (also available from Goldschmidt) And for sale. Other non-limiting examples of dimethyl polysiloxane copolymers also include lauryl dimethyl polysiloxane, difluorenyl polysiloxane copolymer acetate, dimethyl polysiloxane copolymer Adipic acid, dimethyl polysiloxane copolyolamine, dimethyl polysiloxane copolyol alkanoate, difluorenyl polysiloxane copolyol butyl ether, dimethyl polysiloxane copolyol hydroxystearate Dimethyl polysiloxane copolymer isostearate, dimethyl polysiloxane copolymer laurate, dimethyl polysiloxane copolymer methyl ether, difluorenyl polysiloxane copolymer phosphate, and II __- 19- This paper size applies to the Chinese National Standard (CNS) A4 specification (210X297 mm) A7 B7 Δ36291 5. Description of the invention (17) Methylpolysiloxane copolyol stearate. See the International Cosmetic Ingredient Dictionary, (please read the notes on the back before filling out this page) Fifth Edition, 1993, all of which are incorporated herein by reference. The dimethyl polysiloxane co-emulsifier that can be used here is further described in U.S. Patent 4,960,764 issued to Figueroa, Jr., et al. On October 2, 1990; and in SaNogueira, Europe, published on August 30, 1989 Patent EP 330,369; GH Dahms et al. &Quot; Possibilities of New Prescriptions Provided by Polysiloxanes, Cosmetics and Cosmetics' Vol. 110, pp. 91-100, March 1995; M.E. Carlotti et al. " Optimization of W / 0-S Emulsions and Study on Quantitative Relationship between Ester Structure and Emulsion Properties ", Journal of Dispersion Science and Technology, 13 (3) '315-336 (1992); P. Hameyer " Comparison of organic and organic polyoxygen emulsifiers in cosmetic water-in-oil emulsion products. | Happi 28 (4) '88-128 (1991); J. Smid-Korbar et al. Efficiency and Availability of Oxygen Surfactants in Emulsions ", International Journal of Cosmetic Science, Temporary Newsletter, 12,135-139 (1990); and DGKrzysik et al." A novel polysiloxane emulsion for water-in-oil systems &Quot;, Pharmaceutical and Cosmetic Industry 'Vol. 146 (4)', p. 28 · 81 (April 1990); And this portion has the reference. Silicone-free emulsifiers printed here by the Central Standards Bureau of the Ministry of Economic Affairs and Consumer Cooperatives are non-ionic and anionic emulsifiers such as sweet and sour and polyesters, alkoxylated sugar esters and polyesters, and Cl_c30 fatty alcohols. C1-C30 fatty acid esters, C1-C30 fatty alcohols, cl_C30 fatty acid esters, dazzling oxidation derivatives, C1-C30 fatty alcohols, alkene oxides, C1-C30 fatty acid polyglycerides; C1-C30 from vinegar, polyalcohol Esters, ci-C3OSi of polyalcohols, succinic acid compounds, polyoxygenation, "basic fatty chain scale esters, fatty acid sulfonamides, lactobacillus acid salts, colors, and mixtures thereof. See McCutcheon's Detergents and Emulsifiers --- 20-This paper size applies the Chinese National Standard (CNS) A4 specification (21〇 > < 297 mm) A7 B7 43629 5. Description of the invention (π) 'North American version ( 1986), published by Allured Publishing Company; U.S. Patent 5,00n, 681 issued to Ciotti et al. On April 30, 1991; U.S. Patent 4,421,769 issued to Dixon on December 20, 1983; and 1973 US Patent 3,755,560 issued to Dickett et al. On August 28; all four references are incorporated herein by reference. Non-limiting examples of these silicone-free emulsifiers include: polyethylene glycol 20 glucose monolaurate (Polygluconate 20), polyethylene glycol 5 soy alcohol,

Steareth-20, Ceteareth-20, PPG-2 methyl glucosyl distearate, Ceteth-10, polyglucose ester 80, cetyl phosphate, cetyl phosphate, hexadecyl diethanolamine, Polyglucose vinegar 60, glyceryl stearate, PEG-100 stearate, polyoxyethylene glucoside trioleate (polyglucose 85), glucose monooleate 'polyoxyethylene 4 lauryl ether stearin Sodium, Polyglycerol-4 Isostearate, Hexyl Laurate, Stereth 2 ′

Ceteareth-20, PPG-2 methyl glucose ether distearate 'ceteth-io, cetyl diethanolamine phosphate, glyceryl stearate, PEG_1OO stearate purpose, and mixtures thereof β oil-in-water Other preferred topical carriers for emulsions include oil-in-water emulsions. Particularly preferred oil-in-water emulsions are described in detail below. 1-Structuring Agent, A preferred oil-in-water emulsion contains a structurant to assist in the formation of a liquid crystalline gel network structure. The concentration of the structurant is from about 1% to about 20/0, preferably from about 1% to about 10% of the topical carrier. More preferably, from about 3% to about 9% by weight. Including saturated c16 to C30 fatty alcohols, containing about -21-This paper scale is applicable to Chinese national standard cars (CNS > A4 specification (210X297 mm) ----------- S policy-aff Please read the notes on the back before filling in this page} Order printed by the Central Standards Bureau of the Ministry of Economic Affairs, Zhengong Consumer Cooperatives, printed by the Central Standards Bureau of the Ministry of Economic Affairs, printed by the cooperatives ^ A36291_ B7 V. Description of the invention (19) 1 to About 5 moles of saturated ethylene oxide to c: 30 fatty alcohols, saturated

Ci6 to C; 30 diols, saturated cies to 匚 30 monoglyceric acid, saturated ci6 to kerosene fatty acids, and mixtures thereof having an oak point of at least about 45 »c. Preferred structurants include Stearyl alcohol, cetyl alcohol, litol, stearic acid, palmitic acid, polyethylene glycol ethers of stearyl alcohol having an average of about 1 to about 5 ethylene oxide units, having an average of about 1 to about 5 oxidations Polyethylene glycol ethers of cetyl alcohol in ethylene units, and mixtures thereof. More preferably, the structurant of the present invention is selected from the group consisting of stearyl alcohol, steareth-2, steareth-2, steareth-2, steareth-2 having an average of about 2 ethyl acetate units, and steareth-2. Polyethylene glycol ethers of cetyl alcohol of one ethoxylated unit, and a mixture of β or even better structurants thereof are selected from the group consisting of stearyl alcohol, cetyl alcohol, litol, steareth_2, and mixtures thereof. -2, available under the tradename Brij® 72 from iCI Corporation of the United States. 2. Hydrophilic surfactants. Preferred oil-in-water emulsions contain from about 0.05% to about! 0%, preferably from about 1% to about 6%, and more preferably from about 1% to about 3% of at least one hydrophilic surfactant, which can disperse a hydrophobic substance in the aqueous phase (of a topical carrier Weight percent). The surfactant must be at least hydrophilic enough to divide β in water. Suitable surfactants include any of a wide variety of known cationic, anionic, zwitterionic, and amphoteric surfactants. See McCutcheon's Detergents and Emulsifiers, North American Edition (1986), published by Allured Publishing Company; U.S. Patent No. 5,010,681; U.S. Patent No. 4,421,769; and ___- 22- This paper is also applicable to Chinese national standards ( CNS > A4 specification (2 丨 0X297 male) 1 -------- Γ Installation ------ ir ------ ¢-Λ * (Please read the notes on the back first ¢ Fill out this page again) Α7 Β7 ^ 43629 1 V. Description of the invention (20 US patent 3,755,560; all four references are incorporated herein by reference. The exact interface / tongue agent selected depends on the pH and presence of the composition Depending on other ingredients-preferably cationic surfactants, especially dialkyl quaternary ammonium compounds, examples of which are described in U.S. Patent; U.S. Patent 5,15121〇; U.S. Patent 5,120,532; U.S. Patent 4,387,090; U.S. Patent Patents 3,155,591; U.S. Patent 3,929,678; U.S. Patent 3 959,461; ^ ccutcheoi ^ Detergents and Emulsifiers (Beimou Edition 1979) MC Publishing Company; and surfactants by Schwartz et al. New York: Science Press, 1949; this description is here—incorporated as a reference in β Use of a cationic surfactant having the formula comprising as the cationic salt: (Read precautions to fill out the back of the present I) - * 3 R RM-Ν-IR4 +

X Printed by the Central Bureau of the Ministry of Economic Affairs, Shellfish Consumer Cooperative, where Ri is an alkyl group having about 12 to about 30 carbon atoms, or an aromatic, aryl, or alkaryl group having about 12 to about 30 carbon atoms R2, r3 'and trans + are independently selected from hydrogen, an alkyl group having about 1 to about 22 carbon atoms, or an aromatic, aryl, or alkaryl group having about 12 to about 22 carbon atoms; and X is any compatible anion, preferably selected from the group consisting of gas ion, bromide ion, iodide ion, acetate, arm root, nitrate, sulfate, fluorenylsulfate, ethylsulfate, tosylate, Lactate, citrate, glycolate, and its -23- This paper scale is applicable to the Chinese National Standard (CNS) standard (210 × 297 mm) Printed by A3629A, Consumer Work Cooperative, Central Rubbing Bureau, Ministry of Economic Affairs ^ _ V. Description of the invention (21) Mixture. In addition, Ri, R2, R3, and R4 alkyl groups may also contain ester and / or ether linkages, or hydroxyl or amine substituents (for example, alkyl groups may contain polyethylene glycol and polypropylene glycol moieties). More preferably, R is an alkyl group having about 12 to about 22 carbon atoms; R2 is selected from fluorene or an alkyl group having about 1 to about 22 carbon atoms; feet 3 and 114 are independently selected from Η or having about 1 Alkyl groups of up to about 3 carbon atoms; and X, as previously described, is preferably an alkyl group having about 12 to about 22 carbon atoms; R2, I, and R4 are selected from Η or have about 1 to An alkyl group of about 3 carbon atoms; and X is as previously described; or, other useful cationic emulsifiers include amino acids, wherein the above structure Ri or R5CONH- (CH2) n-, where 115 is An alkyl group of 12 to about 22 carbon atoms, and η is about 2 to about 6, more preferably about 2 to about 4, and most preferably an integer of about 2 to about 3. Non-limiting examples of these cationic emulsifiers include stearylamine propyl PG-diammonium gaseous phosphate, rotamine aminopropyl PG-diammonium gaseous, stearylamine aminopropylethyldiamine Ammonium ethoxysulfate, stearylamine aminopropyldifluorenyl (myristyl acetate) gasified ammonium, stearylaminopropyl dimethyl hexadecyl ammonium toluenesulfonate, stearylamine Propyldimethylammonium gasification, stearylaminopropyldimethylammonium lactate, and their complexes. Particularly preferred is hydrasinopropyl PG-diammonium vapor. Non-limiting examples of quaternary ammonium salt cationic emulsifiers are selected from the group consisting of hexadecyl ammonium vaporized, cetyl ammonium bromide, lauryl ammonium vaporized, lauryl bromide, stearyl ammonium vaporized, hard Aliphatic ammonium bromide, hexadecyl dimethyl ammonium vapor, decaxyl monomethyl &gt; odorant, lauryl dimethyl chloride, lauryl dimethyl ammonium bromide, stearyl diammonium Methyl vaporized ammonium, stearyl dimethyl ammonium bromide, -24- This paper size applies to Chinese national standards (CNS &gt; A4 specification (2) 0 × 297 mm &gt; ----- C. (Please read the precautions on the back before filling out this page) A7 B7 A3 62 91 Five 'invention description (22) Decaxyl trimethyl ammonium gaseous, hexadecyl trimethyl bromide Ammonium chloride, lauryl trimethyl ammonium chloride, lauryl trimethyl ammonium bromide, stearyl trimethyl ammonium vaporizer, stearyl dimethyl bromide , Stearyl difluorenyl hexadecyl ditallow dimethyl ammonium vaporized, di-hexadecyl ammonium vaporized, di-hexadecyl ammonium bromide, dilauryl ammonium chloride, dilauryl ammonium bromide '' Distearyl Gasification Press, Distearyl Ammonium Bromide , Di-hexadecylmethyl ammonium vaporized, di-hexadecylmethylammonium bromide, dilaurylfluorenyl ammonium vaporized, dilaurylmethylammonium bromide, distearylmethyl ammonium vaporized , Distearylmethylammonium bromide, and mixtures thereof. In addition, quaternary ammonium salts include those in which C12 to c3C) alkyl carbon chains are derived from tallow fatty acids or coconut fatty acids. The term "tallow" refers to Alkyl groups derived from tallow fatty acids (usually hydrogenated tallow fatty acids), which typically have a mixture of alkane chains ranging from c 16 to C18. Noun, "coconut" refers to alkyl groups derived from coconut fatty acids, which typically have c12 to cl4 A range of alkane chain mixtures. Examples of quaternary ammonium salts derived from these tallow and coconut sources include ditallow diammonium vaporized ammonium 'ditallow dimethyl ammonium methyl sulfate, di (hydrogenated tallow) difluorenyl gasification Ammonium, di (hydrogenated tallow) dimethyl ammonium acetate, ditallow dipropyl ammonium phosphate, ditallow dimethyl ammonium nitrate, bis (cocoalkyl) dimethyl ammonium vaporized, bis (cocoalkyl) dimethyl Ammonium bromide, tallow gasified ammonium, coconut pregasified ammonium, stearylamine PG-Diammonium Gasification Phosphate, Stearyl Amidopropylethyl Ethyloxy Sulfate, Ammonium Stearyl Bismuthyl Propyl Dimethyl Hexadecyl Aryl Dimethyl (Myristyl Acetate) Gasification Ammonium , Stearylamidopropyldimethylhexadecyl ammonium tosylate, stearylamidopropyldimethylammonium vaporized, stearylamidopropyldimethylammonium lactate, and mixtures thereof An example of a quaternary ammonium compound having an ester-bonded alkyl group is ditallowyloxyethyl dimethyl gasification. 25- The paper scale is applicable to the Chinese National Standard (CNS) A4 standard (21 0297 mm). <Installation ------ Order--; ---- 0. (Please read the notes on the back ¾ before filling out this page) Printed by the Industrial Standards Bureau of the Ministry of Economic Affairs I Cooperative Cooperative A3629,. ^ A3629 ,. ^ Printed by the Central Standards Bureau of the Ministry of Economic Affairs, Consumer Cooperatives V. Invention Description (23) Ammonium. More preferred cationic surfactants are selected from the group consisting of chloraminopropyl PG dichloro chloride, dilauryl dimethyl gasification, distearyl dimethyl gasification, and dimyristyl di Methyl vaporized ammonium, dipalmityl dimethyl vaporization, distearyldimethylammonium chloride, stearylaminopropyl pG-diammonium vaporized phosphate, stearylaminopropyl Ethyl diammonium ethoxy sulfate, stearyl aminopropyl dimethyl (myristyl acetate) ammonium vaporized, stearyl amidopropyl dimethyl hexadecyl ammonium toluenesulfonate, stearin Amidopropyldimethylammonium vaporized, stearylamidopropyldimethylammonium lactate, and mixtures thereof. The most preferred cationic surfactant is selected from the group consisting of hydrasinopropyl pG diammonium vapor, dilauryl dimethyl gasification, distearyl dimethyl gasification, dimethocarb Dimethyl ammonium vaporized, dipalmityl dimethyl ammonium vaporized, and their compounds. A preferred combination of a cationic surfactant and a structurant is hydrasinopropyl PG diammonium vapor and / or rosanol, where the ratio is preferably optimized to continuously enhance physical and chemical stability, especially here When combining ionic and / or highly polar solvents. This combination is particularly useful for sunscreen agents such as zinc oxide and octyl methoxycinnamate. A wide variety of anionic surfactants β can also be used herein. See, for example, 'Beauty to Laughlin et al., December 30, 1975, National Patent 3,929,678, all of which are incorporated herein by reference. Non-limiting examples of anionic surfactants include 2-acrylic acid-based salt, and sulfuric acid ester and ammonium acid. 2- Acetyl base salt generally has the formula OCH2CH2SO3M, in which R is an alkyl or olefin of about 10 to about 30 carbon atoms ____- 26-This paper applies the Chinese National Standard (CNS) (210X297) (Published) ί {&quot; 装 — * * (please read the precautions of the West first and then fill out this page) Order A7 Printed by the Consumers' Cooperative of the Central Standards Bureau of the Ministry of Economic Affairs— * in 3 6? (24) and M are water-soluble cations such as ammonium, sodium, potassium, and triethanolamine. Non-limiting examples of these 2-isethionates include a member selected from the group consisting of 2-co isethionate ammonium 2-isethionate, coco-methyl isethionate 2-sodium isethionate, and sodium lauryl methionate , 2-¾Ethyl Red Hard Sodium Acetyl Sodium 'and its mixture 2_ Super Ethyl Acetate. Tiger sulfate and ammonium ethers generally have the formula and RO (C2H4〇) xSO3M, where R is an alkyl or alkenyl group of about 10 to about 30 carbon atoms, X is about 1 to about 10, and M Water-soluble cations such as ammonium, sodium, triethanolamine. Another suitable anionic surfactant is a water-soluble salt of an organic, sulfuric acid reaction product of the following formula: R. I-S 〇3—wherein ^ is selected from the group having about 8 to about 24 ′, preferably about 1 A linear or branched 'saturated aliphatic hydrocarbon group of 0 to about carbon atoms; and M is a cation. Other anionic synthetic surfactants include species known as succinates, olefin sulfonates having from about 12 to about 24 carbon atoms, and b-alkoxyalkanoates. Examples of these materials are Sodium lauryl sulfate and ammonium lauryl sulfate 9 Other anionic materials that can be used herein are soaps of fatty acids (ie, alkali metal salts, such as sodium or potassium salts), typically having from about 8 to about 24 carbon atoms, compared to It is preferably about H) to about 20 carbon atoms. The fatty acids used to make soap can be derived from natural sources, such as glycerol vinegar derived from plant-derived animals (such as 'brown palm oil', coconut oil, soybean oil, castor oil, tallow, lard, etc.) Synthesis of fatty acids. Soap is described in more detail in U.S. Patent 4,557,853, listed above. The size of this paper is in accordance with Chinese National Standards (CNS) Α4 ^ grid (21〇χ297 公 爱) --------- ΛΤ--(Please read the precautions before filling this page) '1Τ r A36291 V. Description of the invention (25) A7 B7 Printed by the Central Bureau of Standards, the Ministry of Economic Affairs, and the Beacon Consumer Cooperative, can also be used here. Amphoteric and zwitterionic surfactants β can be used for the amphoteric and zwitterionic interface activities of the composition of the present invention. Examples of agents are those broadly described as derivatives of aliphatic secondary and tertiary amines, where the aliphatic group may be straight or branched, and where one of the aliphatic substituents contains from about 8 to about 22 carbon atoms (Preferably Cg-C ^ 8) 'and an anionic water-soluble group thereof, such as' Cunyl, phosphonate, sulfate, phosphonate, or phosphonate. Examples are pitiminoacetate 'and iminodialkanoates and aminoalkanoates of the formula RN [(CH2) mC02M] 2 and RNi ^ CH ^ CC ^ M, where m is 1 to 4, R is C8-002 alkyl or alkenyl 'and M is rhenium, alkali metal, earth metal, press' or ammonium alcohol. Also included are imidazoline and ammonium derivatives. Specific examples of suitable amphoteric surfactants include 3-dodecylaminomonopropionate, sodium 3-dodecylaminopropanesulfonate, and N-alkyltaurine, as shown in accordance with US Patent 2,658,072. , Sodium 2-isethionate was prepared by reacting dodecylamine, all of which are incorporated herein by reference; N-Nankenyl aspartic acid, as produced according to the instructions of US Patent 2,438,091, which All incorporated herein by reference; and products sold under the trade name "Miranol" and described in US Patent 2,528,378, all of which are incorporated herein by reference. Examples of useful amphoteric surfactants include phosphates, such as cocoa Aminopropyl PG-diammonium gaseous phosphate (commercially available as Monaquat PTC from Mona Corporation). It can also be used as an amphoteric or zwitterionic surfactant as an internal salt. Examples of internal salts include High-carbon alkyl internal salts, such as coco dimethylcarboxymethyl internal salt, lauryldiamidylcarboxymethyl internal salt, lauryldimethylα carboxyethyl internal salt, cetyldimethylcarboxymethyl Internal salt, hexadecyl dimethyl internal salt (as obtained from Lonza Lonzaine 16SP from the company), lauryl double (2- Jingji ___- 28- ______) This paper size is applicable to China National Standard (CNS) A4 size (210X297 mm) (installation-* * (please first KS Read the notes on the reverse side and fill in this page) Order. Printed by the Central Ministry of Economy, the Ministry of Economic Affairs and Consumer Cooperatives, U 436291 A7 B7 V. Description of the Invention (26> Ethyl) Carboxymethyl Internal Salt, Stearyl Bis (2 -Hydroxypropyl) carboxymethyl internal salt, oleyl dimethyl r-carboxypropyl internal salt, lauryl bis (2-hydroxypropyl) heart carboxyethyl internal salt, coco dimethylthiopropyl internal salt , Stearyl dimethyl thiopropyl internal salt, lauryl dimethyl thioethyl internal salt, lauryl bis (2-merylethyl) thiopropyl internal salt, and sulfonyl internal salt and fluorenylamine Sulfur internal salt (where RCONH (CH2) 3 group is connected to the nitrogen atom of the internal salt), oil-based internal salt (such as the amphoteric Velvetex OLB-50 from Henkel Company), and cocoa chain aminopropyl internal salt (As obtained from Henkel's amphoteric Velvetex BK-35 and BA-35). Other available amphoteric and zwitterionic surfactants include sulphur and hydroxysulphur 'Such as cocoa amine propyl sulfide internal salt (such as obtained from Mirataine CBS of Rhone_ Poulenc company), and the corresponding formula RCON (CH3) CH2CH2C02M roasted carnitine, where r is about 10 Alkyl or alkenyl groups of up to about 20 carbon atoms, and M are water-soluble cations such as sodium, potassium, and trialkanolamine (for example, triethanolamine), a preferred example of which is lauryl meat Sodium amine. 3. Preferred oil-in-water emulsions comprise about 25% to about 98% of a topical carrier, preferably about 65% to about 95% 'more preferably about 70% to about 90% by weight of water. . Conditioning ingredients' A wide variety of conditional ingredients can be used in topical skin compositions as long as the conditional ingredients are physically and chemically compatible with the main ingredients described herein, or will not unduly damage the aesthetics of the composition , Stability or use benefits. -29- This paper size applies to China National Standard (CNS) Α4 size (2 丨 0X297 mm) (Please read the notes on the back before filling this page) Order printed by the Central Standards Bureau of the Ministry of Economic Affairs and Consumer Cooperatives at ______B7 V. Description of the invention (27) Zinc salt The composition of the present invention may further include a complexing agent with a thiol-containing compound before topical application to provide an odor-controlling clamp. The concentration of the clamp agent ranges from about 0.001% to about 10% of the composition, preferably from about 0.001% to about 5%, and more preferably from about 0.1% to about 5% by weight. Preferred I clamping agents include zinc salts, examples of which include zinc acetate, zinc acetate hydrates such as zinc acetate-2-water, zinc aluminum oxide complexes such as zinc spinel, 'zinc diamine, zinc antimonide, Such as zinc bromate_6_water zinc bromate hydrate, zinc bromide, such as zinc carbonate and siderite zinc carbonate, such as zinc gasate_4_water gas zinc acid hydrate, zinc halide, Zinc diamine digas, 'zinc citrate, zinc chromate, zinc dichromate, zinc diphosphate, hexa | iron-based iron fluoride (π) acid zinc, zinc fluoride, such as zinc fluoride-4-water fluoride Zinc hydrate, formic acid, such as zinc gallate _ 2-water zinc formate hydrate, zinc hydroxide, zinc gallate, such as zinc acid _2 • water zinc iodate hydrate, zinc iodide 'zinc Iron oxide complexes, such as zinc nitrate-6-water, zinc nitrate hydrate, zinc nitride, such as zinc oxalate_2_water, zinc oxalate hydrate, such as zinc oxide zinc oxide, such as zinc peroxyacid- 6-water zinc peroxyacid hydrate, such as zinc permanganate-6-water zinc peroxyacid hydrate, zinc peroxide, such as para-fermented zinc acid-8-water para-age acid Zinc hydrate, zinc linate, zinc phosphate hydrate such as zinc phosphate-4-water, Zinc phosphate, zinc propionate, such as zinc selenate-5-water, zirconium phosphate hydrate, zinc silicate, such as zinc acid (2) and zinc acid (4) zinc silicate, such as heteropolar Zinc silicon oxide water complexes, such as zinc hexafluorosilicate-6-water zinc hexafluorosilicate hydrate, zinc stearate, zinc sulfate, such as zinc sulfate-7-water zinc oleate hydrate, Zinc sulfide, such as zinc sulfite-2-water, zinc sulfite hydrate, zinc telluride, zinc thiocyanate, N-acetylsulfonyl L- Magic—1 ^ ------- (袈 ------ Order ------ 0 (Please read the notes on the back before filling out this page) 43 629, A7 ----- ----------------- B7 V. Description of the invention (28) Zinc semideaminate (II), and mixtures thereof. Particularly preferred zinc salts include zinc citrate, zinc oxide, Zinc gasification 'zinc acetate, zinc stearate, zinc sulfate, and mixtures thereof. It has also been found that' «zinc acid is particularly effective in providing odor in topical coatings. Zinc citrate and other zinc salts are believed to act as clamps, To combine the thiol-containing compound in the composition, so as to form the improved stability of acetamidine, and Low malodor formation. Sunscreens, artificial tanning agents, and skin photoreceptors 丨 Sunscreens can also be used in concentrations typically ranging from about 05% to about 20% by weight of the composition for use in the topical compositions of the present invention Examples of suitable anti-building agents are described in U.S. Patent No. 5,087,445; U.S.-China Patent No. 5,073,372; U.S. Patent No. 5,073,371; U.S. Patent No. 4,937,370; U.S. Patent No. 4,999,186; and

Segarin et al. Cosmetic Science and Technology, Chapter VIII ', p. 189 and below, the description is incorporated herein by reference. Printed by the Central Standards Bureau of the Ministry of Economic Affairs, Shellfish Consumer Cooperatives -------- (. Pack! (Please read the precautions on the back before filling out this page) Designated examples of suitable sunscreens include para-methoxy 2-ethylhexyl cinnamate, 2-ethylhexyl N, N-dimethyl-p-aminobenzoic acid, p-aminobenzoic acid, 2-phenylbenzimidazole-5-sulfonic acid Acid, octyl cyanobiphenyl acrylate, oxybenzone, mesitylate salicylate, octyl salicylate, 4,4-methoxytributyltribenzylmethane, 4-isopropylbenzoyl Fluorenylmethane, 3-methyleneidene camphor, 3- (4-methylbenzylidene) camphor, titanium dioxide, oxygen 4 zinc, silica, iron oxide, 4-N of 2,4-dihydroxydiphenyl ring , N- (2-ethylhexyl) methylaminobenzoate, 4-N, N- (2-ethylhexyl) methylaminobenzoate , 4-N, N- (2-ethylhexyl) methylaminobenzoate of 2-hydroxy-4- (2-hydroxyethoxy) diphenyl ketone, 4- (2-hydroxyethoxy Base) Dibenzo-31-This paper standard is in accordance with Chinese Standard (CNS) A4 specification (2 丨 0X297 male thin) A7 B7 at 3629 '· V. Description of invention (29) Base 4-N, N- (2 · ethylhexyl) fluorenylamino benzoate of oxane, and its compounds ^ 'No suntanning agent can also be used in the composition, examples of which include dihydroxy Acetone, glycerol, indole and its derivatives, phospha-DOPA, tyrosine, and tyrosines such as ethyl tyrosate. Skin bleaching (or brightening) agents can also be used, including but not limited to Argonquinone, ascorbic acid, osmic acid, and sodium metabisulfite. Fish moisturizers, wetting agents, and skin conditioners The composition of the present invention may further include a moisturizing agent, a moisturizing agent, and a skin conditioning agent. A variety of these materials can be used, And each may be present in an amount of about 0.001 / 0 to about 20%, more preferably about 1% to about 10%, and most preferably about 2% to about 5%. These materials include guanidine; hydroxy &amp; acid and Glycolates (for example, ammonium and quaternary tiger ammonium); lactic acid and lactate (for example, according to quaternary alkyl); any form of aloe vera (for example, aloe vera gel); such as dextrose, glycerol ' Polyhydric alcohols such as hexanetriol, propylene glycol, butanediol, and hexanediol: polyethylene glycol; sugar and starch; sugar and Powder derivatives (for example, alkoxylated glucose); hyaluronic acid; lactamamine monoethanolamine; acetamide monoethanolamine; and mixtures thereof 3 Propionyl glycerol described in U.S. Patent No. 4,976,953 can also be used here, Incorporated as a reference. Various clrC30 monoesters and polyvinegars of sugars and related substances can also be used. These vinegars are derived from sugar or polyalcohol moieties and one or more carboxylic acid moieties. Depending on the acid and sugar of the components, These esters can be in liquid or solid form at room temperature. Examples of liquid esters include: glucose tetraoleate, soy oil fatty acid (unsaturated) glucose tetra vinegar; 32, oleic acid 32- This paper size is applicable to China National Standard (CNS) Washing grid (2 丨 0X297 gram) (Please read the note on the back before filling in this page) Order by the Ministry of Economic Affairs Printed by the Bureau of Shellfish Consumer Cooperatives, printed by the Central Standard Vehicle Bureau of the Ministry of Economic Affairs, Consumer Works Co., Ltd. 5. Description of the invention (30) Lactose tetraester, arabinose tetraester of linoleic acid, xylose tetralinoleate, semi Lactose Pentaoleate, Glucitol Tetraol Ester, unsaturated soybean oil fatty acid t-glucosyl hexaester, xylose pentaoleate, sucrose tetraoleate, saccharose pentaoleate, sucrose hexaoleate, sucrose heptaoleate, Tibetan sugar eight oil Acid esters, and mixtures thereof. Examples of solid esters include: hexanosyl glucose, in which the carboxylic acid vinegar portion is palmoleate and arachid in a ratio of 1: 2 mole; octaester of raffinose, in which the carboxylic acid ester portion is 1: 3 mole ratio of linoleic acid ester and linoleate; heptaester of maltose, in which the esterified carboxylic acid ester part is a 3: 4 mole ratio of sunflower oil fatty acid and behenate; octaester of Tibetan sugar 'In which the esterified carboxylic acid ester portion is a oleate and rosic acid vinegar in a ratio of 2: 6 moles, and the octave vinegar in which the sugar is acetic acid, in which the acetic acid vinegar is a 1: 3: 4 mole ratio Lauric acid vinegar 'The preferred solid substance for linoleic acid vinegar and rosic acid vinegar β is recommended green poly vinegar', which has a degree of coolness of 7-8, and its fatty acid portion is ci8 mono and / or diunsaturated with rosic acid Ester, molar ratio of unsaturated to lauronate at 1: 7 to 3: 5. A particularly preferred solid sugar polyester is the octaester of sucrose, in which there are about 7 rosyl fatty acid moieties and about 1 oleic acid moieties in the molecule. Esters are further described in U.S. Patent 2,831,854, U.S. Patent 4,005,196 issued to JTandacek on January 25, 1977; U.S. Patent 4,005,195, issued to Jandacek on January 25, 1977, and issued on April 26, 1994 U.S. Patent 5,306,516 to Letton et al .; U.S. Patent 5,305,514 to Letton et al. On April 26, 1994; U.S. Patent 4,797,300 to Jandacek on January 10, 1989; Rizzi et al. On June 15, 1976 U.S. Patent 3,963,699; U.S. Patent 4,518,772 issued to Volpenhein on May 21, 1985; and U.S. Patent -33- issued to Volpenhein on May 21, 1985 (Please read the precautions on the back before filling out this page) -Γ Alas.

-, 1T Standard for Paper-manufactured Standards for Commonly Difficult Countries (CNS) Α4 Specification (210X297 mm) Printed by the Sheller Consumer Cooperative of the Central Standards Bureau of the Ministry of Economic Affairs, .A3 62 9 '; 7 V. Description of the Invention (31) 4,517,360; All of them are incorporated herein by reference. Β Other optional ingredients The composition of the present invention may further include other optional ingredients, including absorbents' abrasives, anti-acne agents, anti-caking agents, anti-foaming agents, anti-microbials Agents, antioxidants, adhesives, bio-additives, buffers, builders, buttoning agents, chemical additives, colorants, cosmetic sword-receiving agents, cosmetic biocides, denaturants, pharmaceutical sword-receiving agents, external analgesics , Film-forming agents, fragrance ingredients, humectants, opalescent agents, pH adjusters, plasticizers, preservatives, propellants, reducing agents, additional skin conditioners, skin protectants, solvents, suspending agents, ultraviolet light absorbers, Emulsifiers, solubilizers, spacers, chemistries other than odor shields described herein. Non-limiting examples of these additional ingredients are listed in the hands of CTFA Cosmetic Ingredients_ and other substances used herein include the following: water-soluble vitamins and their derivatives [eg, 'Biotin C]; antioxidants; polyethylene glycols And polypropylene glycol; polymers that help the film-forming properties and directness of the composition (such as a copolymer of eicosene and vinylpyrrolidone, an example of which is Ganex® V-220 from GAF Chemical Company); maintaining the combination Antimicrobial integrity antiseptics; antioxidants; clamps and barriers "can also be used as cross-linked and non-cross-linked non-ionic and cationic polyacrylamide [for example, with CTFA code polyquaternium 32 (and ) 'Salcare SC92 of mineral oil — and Salcare SC 95 with CTFA code polyquaternium 37 (and) mineral oil (and) ppG-1 trideceth-6, and non-ionic Seppi-Gel polyacrylamide from Seppic ]. It can also be used as cross-linked and non-cross-linked carboxylic acid polymers and copolymers, such as containing one or more derived from acrylic acid ', substituted propionic acid, and this -34- --------- Α Lai ------ Order ------ r—— (Please read the notes on the back before filling this page) This paper music scale is applicable to the Chinese national standard (CNS &gt; A4 specification (2! 〇Χ29 · 7 (Mm) ~ ,, d3 9 V A7 — B7 Printed by the Central Government Bureau of the Ministry of Economic Affairs, printed by Du Feng, V. Description of the Invention (32) Those monomers of acrylic acid and substituted acrylic acid salts and esters, among which Crosslinkers contain two or more carbon-carbon double bonds and are derived from polyhydric alcohols (Examples that can be used herein include carbon polymers, which are propylene crosslinked with allyl ether of sucrose or isoprene tetraol The homopolymer of fei 'and it is obtained from the Carbopol® 900 series of Goodrich' and the acrylic acid c10-30 vinegar with one or more acrylic acid, methacrylic acid, or its short One of the chain (ie, alcohol) vinegars in which the cross-linking agent is allyl ether or isoprene tetraol of sucrose, these copolymers are known as acrylate / acrylic acid C10.30 alkyl ester copolymers, and are obtained from Carbopol® 1342, Pemulen TR-1 &gt; and Pemulen TR-2 from BF Goodrich are commercially available. These carboxylic acid polymers and copolymers are described in more detail in the United States of America, awarded to Haffey et al. On February 11, 1992 Patents 5,087,445; U.S. Patent 4,509,949 issued to Huang et al. On April 5, 1985; U.S. Patent 2,798,503 issued to Brown on July 2, 1957; incorporated herein by reference. See also CTFA Internationalization: ¾ Product Ingredients Dictionary, Fourth Edition, 1991, pages 12 and 80 "can also be used here as an aesthetic ingredient, such as perfumes, pigments, colorants, essential oils, skin-senates, sword-receiving agents, skin smoothing agents, skin treatment agents, etc. Non-limiting examples of these aesthetic ingredients include syringa oil, caps, camphor, eucalyptus oil, eugenol, lactate, witch hazel distillate, myrrhol, dipotassium glycyrrhizin, etc. Examples' Examples below Further describes and confirms that the embodiment of the present invention is within the scope of the present invention. Β This example is for the purpose of description only, and is not to be considered as a limitation of this month, because many variations thereof are possible without departing from the spirit and scope of the present invention. True The following parts of MX are prepared and mixed by using the conventional method. • 35- (Please read the precautions on the back before filling in this X.) The size of this paper is applicable to China National Standards (CNS) A4 specifications (21 × 297 mm) ) &Gt; 4362 9 1 V. Description of the invention (33) Combined with the ingredients listed in the technology combination. The following examples I-IX refer to the definition of odor masking substances: Protective Substance 1 Branch Chemical Substance Substance I Substance II Substance III Benzyl Acetate 31.5 15 18.5 Benzyl Butyrate 0.7 Benzyl Propionate 5 5 1 Citronellol 3-11.5 Citronella Acetate 2 5 1 Diazepam. 5-.2 Decanal--1 Dihydrolauric oleyl alcohol 4.5 10 5 Trifoliol 5_ 10 3,5 cemetyl acetate 4 5 1 cemetyl formate ** 4.5 hexyl cinnamaldehyde 8 7 3.3 f Carone 1.5--Shionone r methyl 2 1-Laurelaldehyde-5 Balsamic acetic acid 3 8 4 Methyl anthranilate-.5 PT Bucinal / Lilial 1.0 5 Phenyl ethyl acetate 5 7 Phenyl Ethylene_ 25 13 15 Isoprene Acetate 2. 8 Menenol-3 2 Verdox 4 3 Vertenex-5 10 Total 100 100 100 --------- (Package-_4 (Please read the notes on the back before filling out this page) The size of the paper scale is applicable to the Chinese National Standard (CNS) M size (210X297 mm) Economy Printed by the Central Government Bureau of the Ministry of Industry and Consumer Cooperatives, A 3 6 2 9 1 A7 _____B7 V. Description of the invention (34) Example I: Oil-in-water emulsion composition wt% PPG-15 stearyl ether 3.25 glycerol 3.0 stearyl alcohol 2.028 N-Ethyl-L-hemiphanic acid 2.0 Sodium hydroxide (50% by weight aqueous solution) 1.28 Steareth-2 1.097 Polyethylene 1.0 Dimethicone 1.0 Distearyldimethylammonium vapor 0.95 ring Methylpolysiloxane (and) Dimethicone 0.75 Cetyl alcohol 0.559 Alcohol 0.5 Steareth-21 0.366 Methyl p-hydroxybenzoate 0.25 Isopropyl alcohol 0.221 Odor shield substance (Substance I) 0.1 Water remaining amount Example II: Polysiloxane encapsulated emulsion r Ingredients wt% Cyclomethylpolysiloxane 15 Ethanol 3 Glycerin 3 -37- —.--------- "Loading--(Please read the first Note: Please fill in this page before filling in this page.) The paper size is applicable to the Chinese National Standard (CMS) A4 specification (210X297 mm) & gt 436291 V. Description of the invention (35) A7 B7 polyglyceryl-4 isostearate (and) sixteen 2.5 dimethyl polysiloxane copolyol (and) laurylhexyl cyclomethicone (and ) Dimethicone copolyol 2.5 Hexanediol N-Ethyl-L-cysteine zinc citrate sodium hydroxide (50% by weight in water) 0.95 EDTA tetrasodium salt benzyl alcohol 0.3 p-hydroxyphenylhydrazone Methyl Ester 0.2 A citric acid odor military substance (Substance I) 0.2 Water 2 2 1 0.5 0.2 The rest of the amount (please read the precautions on the back before filling this page) Example III: Waterborne Gel Gongfa Cooperative Co., Ltd. Printed Parts Glycerin Hexylene Glycol N-Ethyl-L-cysteine Dimethicone Carbopol 980 Zinc Citrate Argon Oxide Sodium Alcohol 0.5 Methyl Paraben 3 2 2 1 0.9 Ή 38- This paper size applies to China National Standards (CNS &gt; A4 size (210X297 mm) 'ν A3 62 9 1 a? Β7 V. Description of the invention (36) 0.2 Citric acid 02 Odor cover Protective substance (substance 01 EDTA disodium salt QQ3

Keltro1 τ, the remaining amount of water,

Examples IV-VI Each formulation is described in the composition of each example MII, all ingredients are the same, except that substance II is used as an odor masking substance instead of substance I.

Examples VII-IX The formulations described in each Example ^ 111 were of the same composition ‘All ingredients are the same’ except that Substance II is used as an odor shield substance instead of Substance 1. When applied topically to human skin, 'real-each paper composition described in Example 1-1X does not emit excessive malodor accompanied by thiols or sulfur compounds' and when applied topically, each composition improves the appearance of the skin . —! Ί?! (Please read the notes on the back and fill in this X first) Order printed by the Consumer Cooperatives of the Central Bureau of Standards of the Ministry of Economic Affairs -39 This paper uses the Chinese National Standard (CNS) A4 size (210X297 mm)

Claims (1)

Bu 436291 A8 Patent Application No. 85Π3457 Ββ Chinese Patent Application Amendment (Year 89) DS Printed by the Central Slope Bureau of the Ministry of Economic Affairs, Consumer Cooperatives (a) A compound with a weight ratio of 0_1% to 100%, selected from the group consisting of derivatives of N-acetamidine and N-acetamidine , Pharmaceutically acceptable salts of N-acetamidine cysteine, pharmaceutically acceptable salts of N-acetamidine cysteine, and mixtures thereof, in which derivatives of ammonium cysteine include esters, Amines, anhydrides, and thioesters and thioethers of thiol-based moieties; (b) 0.01% to 0.5% by weight odor-shielding substance selected to cover the compound (a) topically applied to the skin The accompanying malodor, wherein the odor-protecting substance comprises the following fragrance chemicals (i) 35% to 95% by weight of aromatic esters, aliphatic esters or mixtures thereof, which have a molecular weight of 120 to 205; (ii) Aromatic alcohols, aliphatic alcohols or mixtures thereof having a weight ratio of 4% to 60%, which have a molecular weight of 110 to 180; (iii) 0.05% to 20 ° /. A weight ratio of an aliphatic ketone having a molecular weight of less than 2 10; (iv) 0.1 to 20% by weight of an aromatic aldehyde, an aliphatic aldehyde, or a mixture thereof having a molecular weight of 100 to 225; (v) not exceeding 20% by weight of perfume chemicals selected from the group consisting of aromatic ethers, aliphatic ethers, aliphatic esters, aromatic esters, or mixtures thereof, having a molecular weight of at least 210; and (c) a cosmetically acceptable topical carrier 》 2. The composition according to item 1 of the patent application park, in which the odor military protective material contains the standard of paper support standards (0?) 6 4 wash grid (210 &gt; &lt; 297 public *)- --Ρ --- 装 ------ Order ------ 0 ^-f # (Please read the note on the back before filling in this page) 6. Application patent range 436291 (i) 40% to 85% by weight of aromatic esters, aliphatic esters or mixtures thereof having a molecular weight of 120 to 205; (ii) 10% to 50¼ by weight of aromatic alcohols' Aliphatic alcohols or mixtures thereof having a molecular weight of 110 to 180; (iii) 0.1% to 15% by weight of an aliphatic ketone having a molecular weight of less than 210; (iv) 0.2% to 15% by weight of an aromatic Family aldehydes, aliphatic aldehydes or mixtures thereof having a molecular weight of 100 to 225; and (v) perfume chemicals not exceeding 10% by weight, selected from aromatic ethers, aliphatic ethers, aliphatic esters, aromatic esters , Or a mixture thereof, which has a molecular weight of at least 210. 3. A composition according to item 2 of the scope of patent application, wherein the odor-protecting substance comprises (i) an aromatic ester, an aliphatic ester or a mixture thereof in a weight ratio of 40% to 85%, which has a molecular weight of 150 to 200; ii) 10% to 50% by weight of aromatic alcohols, aliphatic alcohols, or mixtures thereof, having a molecular weight of 120 to 160; (iii) 0.1% to 15% by weight of aliphatic ketones, which have a molecular weight of less than 16 to Molecular weight of 200; (iv) 0.2% to 15% by weight of aromatic aldehydes, aliphatic aldehydes or mixtures thereof having a molecular weight of 130 to 200; and (v) perfume chemicals not exceeding 5% by weight, selected from Including aromatic hydrazones, aliphatic ethers, aliphatic esters' aromatic esters *, or mixtures thereof, having a molecular weight of at least 2-10. -2- The size of this paper applies to China B Country Interpolation (CNS) 8-4 specification {210X297 mm) (please read the precautions on the back before filling out this page) and order it from the Central Labor Bureau of the Ministry of Economic Affairs Packed with AS B8 C8 D8 436291, Chinese patent application range 4. The composition according to item 2 of the patent application range, wherein the compound (&amp;) is N. acetamyl-L-cysteine. 5. The composition according to item 4 of the scope of patent application, wherein the composition comprises 0.02% to 0.3% by weight of an odor shield substance. 6. The composition according to item 5 of the scope of patent application, wherein the composition comprises 0.03% to 0.2% by weight of an odor shield substance, and 0.01% to 10%. / 〇 by weight ratio of N-acetamyl-L-cysteine. 7. The composition according to item 4 of the patent application, wherein the fragrance chemical is selected from the group consisting of: 2,6,10, trimethyl-9-fluorene--fluorene-1-methyl; 3-methyl-1- Butanol acetate; 4-methoxybenzaldehyde; benzaldehyde; benzyl acetate; benzyl butyrate; benzyl propionate; 1- (2,6,6-trimethyl-1-cyclohexane 埽丨 -yl) -2_ buten-1-one; Ar-hexenoic acid; 3,7-dimethyl-6-octenol; 3,7-dimethyl-6-octyl acetate &quot; 1--1 brewed; 3,7-dimethyl-2,6-octanediononitrile; 2-methyl-3- (p-isopropylphenyl) propanal; decaldehyde; ι · (2,6 , 6 · trimethyl-3-cyclohexene-1-yl) -2-butene-1-_; 3-methyleneidene-7-methyloctyl-7-ol; ethyl vanillin; 3- (3-isopropylphenyl) butyraldehyde; 3,7-dimethyl-2.6-octadien-1-ol; 3,7-diamidino-2,6-octadien-1-yl acetate Esters; trans 3,7-dimethyl-2,6-octadioxane formate; 3J-dimethyl-2,6-octadienenitrile; α-methyl-3,4- (methylenedioxy) Hydrocinnaldehyde; Xianghuaxiangaldehyde; α-n-hexylcinnamic acid; hydroxycitronellal; 4- (2,6.6-trimethyl-1-cyclohexyl-1-yl) -3 -butan-2- Same as S, 4- (2,6,6-trimethyl-1-cyclohexyl-1 · yl) -3 -butane '-2-S Identical, Ethyl Ester * —Isoamidine; Laurel; 3-Ethyl-3,7-dimethyl-1,6-octadiene acetate; Agarum n-butyrate; C Acid 3.7-dimethyl-1,6-octadien-3-yl ester; 4- (4-hydroxy-4-methylfluorenyl)--3-This paper is applicable to the standards of the poor countries (CNS) Λ4 wash grid (210X297 mm) (please read the precautions on the back before filling out this page) • 11 Γ Printed by the Central Standards Bureau of the Ministry of Economic Affairs, Consumer Cooperatives, 埽 1_ 埽 aldehyde; 2-amine Methyl benzyl carboxylate; methyl nonyl aceton '2-methyl_3- (p-tertiary-butylphenyl) propanal; oxy_2-phenylacetone; phenylacetaldehyde dimethyl Acetal; Phenylethyl acetate; Phenylethanol; 2-methylbutene-2 · ol-4_acetate; p-cocoon- 丨 _ene-8_ol; p-fluorene-1-ene · 1 Alcohols: undecyl aldehyde; undecenal; 4-hydroxy-3_methoxybenzyl; 2-tert-butyl cyclohexyl acetate; 4-tert-butyl cyclohexyl acetate; and mixtures thereof. 8. The composition according to item 1 of the scope of patent application, wherein the cosmetically acceptable topical carrier is selected from the group consisting of an oil-in-water emulsion, a water-in-oil emulsion, a polyoxygenated water-in-oil emulsion, and an aqueous gel. 9. A composition according to item 1 of the scope of patent application, wherein the composition further comprises 0.001% to 10% by weight of a zinc salt. 10. Composition according to item 9 of the scope of patent application, wherein the zinc salt is selected from the group consisting of zinc citrate, zinc oxide, zinc stearate, zinc sulfate, gasification, zinc acetate, and mixtures thereof The composition of item ο, wherein the salt is zinc citrate. 12. A topical composition comprising: U) 0% to 10. / 〇 by weight ratio of N-ethyl alcohol-L-cysteine; (b) 0.02% to 0.3% by weight of odor shield material, which is selected to cover N-ethyl alcohol-L-half The malodor accompanying the topical application of amino acids on the skin, wherein the odor-protecting substance contains the following fragrance chemicals (i) 40% to 85¾ by weight of aromatic esters' aliphatic esters or mixtures thereof, which have 120 Molecular weight to 205; / 2. Patent application scope: Printed by βς 工 消费 consuming cooperative of the Central Bureau of Standards of the Ministry of Economic Affairs «. (11) 10% to 50% by weight of aromatic alcohols, aliphatic alcohols or mixtures thereof, having a molecular weight of 110 to 180; (iii) 0.1% to 15% by weight of aliphatic fluorene having a molecular weight of less than 21%; (iv) 0.2¾ to 15% by weight of aromatic aldehydes, aliphatic aldehydes or mixtures thereof having a molecular weight of 100 to 225 (V) not more than 5% by weight of fragrance chemicals selected from aromatic ethers, aliphatic ethers, aliphatic esters, aromatic esters, or mixtures thereof, having a molecular weight of P ^ 210; _0_001% to 10% % By weight of zinc citrate; and a cosmetically acceptable topical carrier selected from the group consisting of oil-in-water emulsions and water-in-oxygen emulsions "13.-A topical composition comprising (a) 0.1 to 1% 〇% by weight of a compound selected from the group consisting of v. Ethyl cysteine, N-ethyl cysteine derivatives, pharmaceutically acceptable salts of N-ethyl cysteine, N-ethyl Pharmacologically acceptable salts of derivatives of hemicanine and mixtures thereof, of which the derivatives of N-acetamidine semi-deaminated acid include esters, market; amines, liver, and sulfur G of the sulfur moiety with the purpose sulfide; (b) 0.001% to 10% wt% of zinc citrate; and the (c) of a cosmetically acceptable topical carrier. 14. The composition according to item 13 of the patent application contains 0.01% to 5% by weight. /. Of zinc citrate. 15. The composition according to item 14 of the scope of patent application, wherein the composition package includes the composition package -------- ^ qi-- (please read the precautions on the back before filling this page) Order- 5 "Paper" scale applies to two or two kneading ratios (CNS) A4 specifications (210X297 mm) 43 629 '·:---, the scope of patent application M Β8 C8 D8 contains 0.1 ° /. To 0.5% by weight of zinc citrate 16. The composition according to item 13 of the application, wherein the compound (&amp;) is N-ethyl-L-cysteine. Π, The composition according to item 16 of the scope of the patent application, wherein the composition contains 0.1% to 10% by weight of N-acetamido-L-cysteine. 18. The composition according to item n of the scope of patent application, wherein the topical carrier is selected from the group consisting of an oil-in-water emulsion, a water-in-oil emulsion, a polysiloxane emulsion ^ and an aqueous gel III nnn I n 1, 1¾ n * (Please read the note on the back, then write the% 1 "-Γ Printed by the Central Sample and Half-office Consumer Cooperative of the Ministry of Economic Affairs, the paper size is in accordance with the Chinese National Standard (CNS) A4 (2 丨 OX297 mm) Bu 436291 A8 Patent No. 85Π3457 Patent Application β β Chinese Patent Application Scope Amendment (Year 89) DS Printed by the Central Slope Bureau of the Ministry of Economic Affairs, Consumer Cooperatives (a) A compound with a weight ratio of 0_1% to 100%, selected from the group consisting of derivatives of N-acetamidine and N-acetamidine , Pharmaceutically acceptable salts of N-acetamidine cysteine, pharmaceutically acceptable salts of N-acetamidine cysteine, and mixtures thereof, in which derivatives of ammonium cysteine include esters, Amines, anhydrides, and thioesters and thioethers of thiol-based moieties; (b) 0.01% to 0.5% by weight odor-shielding substance selected to cover the compound (a) topically applied to the skin The accompanying malodor, wherein the odor-protecting substance comprises the following fragrance chemicals (i) 35% to 95% by weight of aromatic esters, aliphatic esters or mixtures thereof, which have a molecular weight of 120 to 205; (ii) Aromatic alcohols, aliphatic alcohols or mixtures thereof having a weight ratio of 4% to 60%, which have a molecular weight of 110 to 180; (iii) 0.05% to 20 ° /. A weight ratio of an aliphatic ketone having a molecular weight of less than 2 10; (iv) 0.1 to 20% by weight of an aromatic aldehyde, an aliphatic aldehyde, or a mixture thereof having a molecular weight of 100 to 225; (v) not exceeding 20% by weight of perfume chemicals selected from the group consisting of aromatic ethers, aliphatic ethers, aliphatic esters, aromatic esters, or mixtures thereof, having a molecular weight of at least 210; and (c) a cosmetically acceptable topical carrier 》 2. The composition according to item 1 of the patent application park, in which the odor military protective material contains the standard of paper support standards (0?) 6 4 wash grid (210 &gt; &lt; 297 public *)- --Ρ --- 装 ------ Order ------ 0 ^-f # (Please read the note on the back before filling in this page)