TW369526B - Diazabicyclic neurokinin antagonists - Google Patents

Diazabicyclic neurokinin antagonists

Info

Publication number: TW369526B
Authority: TW; Taiwan
Prior art keywords: phenyl; diazabicyclic; compounds; substituted; benzothiazolyl
Prior art date: 1993-12-29

Application number

TW083111052A

Other languages

English (en)

Inventor

Harry R Howard Jr

Kevin D Shenk

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-12-29

Filing date

1994-11-28

Publication date

1999-09-11

1994-11-28 Application filed by Pfizer filed Critical Pfizer

1999-09-11 Application granted granted Critical

1999-09-11 Publication of TW369526B publication Critical patent/TW369526B/zh

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Neurosurgery (AREA)
Immunology (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Anesthesiology (AREA)
Otolaryngology (AREA)
Rheumatology (AREA)
Hospice & Palliative Care (AREA)
Pulmonology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

TW083111052A 1993-12-29 1994-11-28 Diazabicyclic neurokinin antagonists TW369526B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US17503493A	1993-12-29	1993-12-29

Publications (1)

Publication Number	Publication Date
TW369526B true TW369526B (en)	1999-09-11

Family

ID=22638565

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
TW083111052A TW369526B (en)	1993-12-29	1994-11-28	Diazabicyclic neurokinin antagonists

Country Status (26)

Country	Link
US (2)	US5854239A (zh)
EP (1)	EP0737194B1 (zh)
JP (1)	JP2895630B2 (zh)
KR (1)	KR100197454B1 (zh)
CN (1)	CN1046515C (zh)
AT (1)	ATE177099T1 (zh)
AU (1)	AU699465B2 (zh)
BR (1)	BR9408450A (zh)
CA (1)	CA2180263C (zh)
CO (1)	CO4230019A1 (zh)
CZ (1)	CZ282567B6 (zh)
DE (1)	DE69416869T2 (zh)
DK (1)	DK0737194T3 (zh)
ES (1)	ES2127946T3 (zh)
FI (1)	FI108296B (zh)
GR (1)	GR3029853T3 (zh)
HU (1)	HUT74682A (zh)
IL (1)	IL112118A (zh)
NO (1)	NO305600B1 (zh)
NZ (1)	NZ274915A (zh)
PE (1)	PE49395A1 (zh)
PL (1)	PL179435B1 (zh)
RU (1)	RU2124014C1 (zh)
TW (1)	TW369526B (zh)
WO (1)	WO1995018129A1 (zh)
ZA (1)	ZA9410339B (zh)

Families Citing this family (70)

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EP0737194B1 (en) *	1993-12-29	1999-03-03	Pfizer Inc.	Diazabicyclic neurokinin antagonists
FR2786770B1 (fr) *	1998-12-04	2001-01-19	Synthelabo	Derives de 1,4-diazabicyclo[3.2.2.]nonane, leur preparation et leur application en therapeutique
AU2001275524B2 (en) *	2000-06-12	2006-02-02	University Of Rochester	Method of treating symptoms of hormonal variation, including hot flashes, using tachykinin receptor antagonist
FR2812635B1 (fr) *	2000-08-01	2002-10-11	Aventis Pharma Sa	Nouveaux composes heterocycliques, preparation et utilisation comme medicaments notamment comme anti- bacteriens
SE0003795D0 (sv) *	2000-10-20	2000-10-20	Astrazeneca Ab	Pharmaceutically useful compounds
FR2825705B1 (fr) *	2001-06-08	2005-05-20	Aventis Pharma Sa	Nouveaux composes heterocycliques, leur preparation et leur utilisation comme medicaments, notamment comme anti-bacteriens
FR2835186B1 (fr)	2002-01-28	2006-10-20	Aventis Pharma Sa	Nouveaux composes heterocycliques, actifs comme inhibiteurs de beta-lactamases
FR2844273B1 (fr)	2002-09-05	2008-04-04	Aventis Pharma Sa	Nouveaux composes heterocycliques, procede et intermediaires de preparation et utilisation comme medicament, notamment comme inhibiteurs de beta-lactamases et anti-bacteriens.
FR2848210B1 (fr) *	2002-12-06	2007-10-19	Aventis Pharma Sa	Nouveaux composes heterocycliques, leur preparation et leur utilisation comme medicaments, notamment comme anti-bacteriens et inhibiteurs de beta-lactamases
US7439253B2 (en)	2002-12-06	2008-10-21	Novexel	Heterocyclic compounds, their preparation and their use as medicaments, in particular as antibacterials and beta-lactamase inhibitors
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UA95454C2 (uk)	2005-07-15	2011-08-10	Амр Текнолоджи, Інк.	Арил- і гетероарилзаміщені тетрагідробензазепіни і їх застосування для блокування зворотного захоплення норепінефрину, допаміну і серотоніну
EP1940842B1 (en)	2005-09-29	2012-05-30	Merck Sharp & Dohme Corp.	Acylated spiropiperidine derivatives as melanocortin-4 receptor modulators
GB0603041D0 (en)	2006-02-15	2006-03-29	Angeletti P Ist Richerche Bio	Therapeutic compounds
EP2083831B1 (en)	2006-09-22	2013-12-25	Merck Sharp & Dohme Corp.	Method of treatment using fatty acid synthesis inhibitors
US20110218176A1 (en)	2006-11-01	2011-09-08	Barbara Brooke Jennings-Spring	Compounds, methods, and treatments for abnormal signaling pathways for prenatal and postnatal development
TWI454262B (zh) *	2006-11-02	2014-10-01	Targacept Inc	菸鹼乙醯膽鹼受體亞型選擇性之二氮雜雙環烷類醯胺
AU2008204380B2 (en)	2007-01-10	2013-08-15	Msd Italia S.R.L.	Amide substituted indazoles as poly(ADP-ribose)polymerase (PARP) inhibitors
AU2008233662B2 (en)	2007-04-02	2012-08-23	Msd K.K.	Indoledione derivative
JP5501227B2 (ja)	2007-06-27	2014-05-21	メルク・シャープ・アンド・ドーム・コーポレーション	ヒストンデアセチラーゼ阻害剤としての４−カルボキシベンジルアミノ誘導体
PL2666774T3 (pl)	2008-01-18	2015-06-30	Merck Sharp & Dohme	Inhibitory beta-laktamazy
JP2011515343A (ja)	2008-03-03	2011-05-19	タイガーファーマテック	チロシンキナーゼ阻害薬
US9156812B2 (en)	2008-06-04	2015-10-13	Bristol-Myers Squibb Company	Crystalline form of 6-[(4S)-2-methyl-4-(2-naphthyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]pyridazin-3-amine
WO2010114780A1 (en)	2009-04-01	2010-10-07	Merck Sharp & Dohme Corp.	Inhibitors of akt activity
MX2011011907A (es)	2009-05-12	2012-01-20	Albany Molecular Res Inc	7-([1,2,4,]triazolo[1,5-a]piridin-6-il)-4-(3,4-diclorofenil)-1,2, 3,4-tetrahidroisoquinolina y uso de la misma.
MX2011011901A (es)	2009-05-12	2012-01-20	Albany Molecular Res Inc	Tetrahidroisoquinolinas aril, heteroaril, y heterociclo sustituidas y uso de las mismas.
KR20120023072A (ko)	2009-05-12	2012-03-12	브리스톨-마이어스 스큅 컴퍼니	（Ｓ）-7-（〔1,2,4〕트리아졸〔1,5-ａ〕피리딘-6-일）-4-（3,4-디클로로페닐）-1,2,3,4-테트라하이드로이소퀴놀린의 결정형 및 이의 용도
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EP2770987B1 (en)	2011-10-27	2018-04-04	Merck Sharp & Dohme Corp.	Novel compounds that are erk inhibitors
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EP2844261B1 (en)	2012-05-02	2018-10-17	Sirna Therapeutics, Inc.	SHORT INTERFERING NUCLEIC ACID (siNA) COMPOSITIONS
JP6265892B2 (ja) *	2012-05-30	2018-01-24	ＭｅｉｊｉＳｅｉｋａファルマ株式会社	新規β−ラクタマーゼ阻害剤とその製造法
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US20140206667A1 (en)	2012-11-14	2014-07-24	Michela Gallagher	Methods and compositions for treating schizophrenia
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Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3494923A (en) *	1965-05-28	1970-02-10	Sterling Drug Inc	1,2,3,4,5,8-hexahydro-1,5-methanobenzo (f)(1,4)diazocine
ES2065175T3 (es) *	1991-03-01	1995-02-01	Pfizer	Derivados de 1-azabiciclo(3.2.2)nonan-3-amina.
EP0737194B1 (en) *	1993-12-29	1999-03-03	Pfizer Inc.	Diazabicyclic neurokinin antagonists

1994
- 1994-11-14 EP EP94931148A patent/EP0737194B1/en not_active Expired - Lifetime
- 1994-11-14 NZ NZ274915A patent/NZ274915A/en unknown
- 1994-11-14 BR BR9408450A patent/BR9408450A/pt not_active Application Discontinuation
- 1994-11-14 AU AU80021/94A patent/AU699465B2/en not_active Ceased
- 1994-11-14 WO PCT/IB1994/000352 patent/WO1995018129A1/en active IP Right Grant
- 1994-11-14 KR KR1019960703516A patent/KR100197454B1/ko not_active IP Right Cessation
- 1994-11-14 PL PL94315193A patent/PL179435B1/pl unknown
- 1994-11-14 CZ CZ961886A patent/CZ282567B6/cs not_active IP Right Cessation
- 1994-11-14 AT AT94931148T patent/ATE177099T1/de not_active IP Right Cessation
- 1994-11-14 ES ES94931148T patent/ES2127946T3/es not_active Expired - Lifetime
- 1994-11-14 DK DK94931148T patent/DK0737194T3/da active
- 1994-11-14 RU RU96116128A patent/RU2124014C1/ru not_active IP Right Cessation
- 1994-11-14 HU HU9601790A patent/HUT74682A/hu unknown
- 1994-11-14 DE DE69416869T patent/DE69416869T2/de not_active Expired - Fee Related
- 1994-11-14 CN CN94194665A patent/CN1046515C/zh not_active Expired - Fee Related
- 1994-11-14 US US08/669,283 patent/US5854239A/en not_active Expired - Fee Related
- 1994-11-14 JP JP7508341A patent/JP2895630B2/ja not_active Expired - Fee Related
- 1994-11-14 CA CA002180263A patent/CA2180263C/en not_active Expired - Fee Related
- 1994-11-28 TW TW083111052A patent/TW369526B/zh active
- 1994-12-21 PE PE1994257627A patent/PE49395A1/es not_active Application Discontinuation
- 1994-12-22 IL IL11211894A patent/IL112118A/en not_active IP Right Cessation
- 1994-12-23 CO CO94058032A patent/CO4230019A1/es unknown
- 1994-12-28 ZA ZA9410339A patent/ZA9410339B/xx unknown
- 1994-12-28 FI FI946140A patent/FI108296B/fi not_active IP Right Cessation
1996
- 1996-06-28 NO NO962742A patent/NO305600B1/no unknown
1998
- 1998-11-23 US US09/198,171 patent/US6110919A/en not_active Expired - Fee Related
1999
- 1999-04-05 GR GR990400941T patent/GR3029853T3/el unknown

Also Published As

Publication number	Publication date
PE49395A1 (es)	1996-01-06
NO962742L (no)	1996-06-28
FI108296B (fi)	2001-12-31
ATE177099T1 (de)	1999-03-15
PL315193A1 (en)	1996-10-14
AU8002194A (en)	1995-07-17
AU699465B2 (en)	1998-12-03
CN1046515C (zh)	1999-11-17
FI946140A0 (fi)	1994-12-28
CO4230019A1 (es)	1995-10-19
JP2895630B2 (ja)	1999-05-24
PL179435B1 (pl)	2000-09-29
RU2124014C1 (ru)	1998-12-27
IL112118A0 (en)	1995-03-15
IL112118A (en)	1998-10-30
CZ282567B6 (cs)	1997-08-13
WO1995018129A1 (en)	1995-07-06
CN1139434A (zh)	1997-01-01
EP0737194A1 (en)	1996-10-16
GR3029853T3 (en)	1999-07-30
KR100197454B1 (ko)	1999-06-15
HU9601790D0 (en)	1996-09-30
NO305600B1 (no)	1999-06-28
CA2180263C (en)	2000-05-16
US5854239A (en)	1998-12-29
FI946140A (fi)	1995-06-30
DE69416869D1 (de)	1999-04-08
JPH09500904A (ja)	1997-01-28
ZA9410339B (en)	1996-06-28
DE69416869T2 (de)	1999-07-01
US6110919A (en)	2000-08-29
NZ274915A (en)	1997-11-24
HUT74682A (en)	1997-01-28
CZ188696A3 (en)	1996-10-16
ES2127946T3 (es)	1999-05-01
DK0737194T3 (da)	1999-09-27
EP0737194B1 (en)	1999-03-03
NO962742D0 (no)	1996-06-28
BR9408450A (pt)	1997-08-05

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