TW360641B - Novel substituted 7-membered nitrogen ring compounds, their preparation, and their use for the treatment of pain - Google Patents
Novel substituted 7-membered nitrogen ring compounds, their preparation, and their use for the treatment of painInfo
- Publication number
- TW360641B TW360641B TW085115322A TW85115322A TW360641B TW 360641 B TW360641 B TW 360641B TW 085115322 A TW085115322 A TW 085115322A TW 85115322 A TW85115322 A TW 85115322A TW 360641 B TW360641 B TW 360641B
- Authority
- TW
- Taiwan
- Prior art keywords
- pain
- preparation
- treatment
- membered nitrogen
- ring compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/08—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 not condensed with other rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Physics & Mathematics (AREA)
- Optics & Photonics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Compounds of the formula, as well as their pharmaceutically acceptable salts, and pharmaceutical compositions comprising the novel compounds. The novel compounds of the formula (I) are useful in the management of pain. A compound of the formula (I), in which R7 and R8 separately represent a C1-C6-alkyl; B is selected from phenyl, naphthyl, each separately being mono- or di-substituted by CONR5R6 and OR5, in which R5 and R6 are as defined in R7 and R8; and R1 is selected from hydrogen, branched or linear C1-C6-alkyl, and C3-C8-cycloalkyl; and pharmaceutically acceptable salts thereof.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE9504662A SE9504662D0 (en) | 1995-12-22 | 1995-12-22 | New compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TW360641B true TW360641B (en) | 1999-06-11 |
Family
ID=20400740
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW085115322A TW360641B (en) | 1995-12-22 | 1996-12-11 | Novel substituted 7-membered nitrogen ring compounds, their preparation, and their use for the treatment of pain |
Country Status (21)
| Country | Link |
|---|---|
| EP (1) | EP0873322A1 (en) |
| JP (1) | JP2000502680A (en) |
| KR (1) | KR19990076649A (en) |
| CN (1) | CN1209126A (en) |
| AU (1) | AU706436B2 (en) |
| BR (1) | BR9612206A (en) |
| CA (1) | CA2239162A1 (en) |
| CZ (1) | CZ176798A3 (en) |
| EE (1) | EE9800195A (en) |
| HU (1) | HUP9900105A3 (en) |
| IL (1) | IL124997A0 (en) |
| IS (1) | IS4768A (en) |
| NO (1) | NO982863L (en) |
| NZ (1) | NZ324888A (en) |
| PL (1) | PL327538A1 (en) |
| SE (1) | SE9504662D0 (en) |
| SK (1) | SK81998A3 (en) |
| TR (1) | TR199801184T2 (en) |
| TW (1) | TW360641B (en) |
| WO (1) | WO1997023467A1 (en) |
| ZA (1) | ZA9610355B (en) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE9504661D0 (en) * | 1995-12-22 | 1995-12-22 | Astra Pharma Inc | New compounds |
| US6441172B1 (en) | 1996-11-07 | 2002-08-27 | Torrey Pines Institute For Molecular Studies | Diketodiazacyclic compounds, diazacyclic compounds and combinatorial libraries thereof |
| US7799337B2 (en) | 1997-07-21 | 2010-09-21 | Levin Bruce H | Method for directed intranasal administration of a composition |
| GB9804734D0 (en) * | 1998-03-05 | 1998-04-29 | Pfizer Ltd | Compounds |
| EE9900336A (en) | 1999-10-27 | 2000-10-16 | Bellakem O� | Cycle operation for the disposal of waste containing polymeric compounds |
| RU2186295C2 (en) | 1999-10-27 | 2002-07-27 | Беллакем Ою | Cyclic-action plant for utilization of wastes containing polymer compounds |
| US8473062B2 (en) | 2008-05-01 | 2013-06-25 | Autonomic Technologies, Inc. | Method and device for the treatment of headache |
| US8412336B2 (en) | 2008-12-29 | 2013-04-02 | Autonomic Technologies, Inc. | Integrated delivery and visualization tool for a neuromodulation system |
| US9320908B2 (en) | 2009-01-15 | 2016-04-26 | Autonomic Technologies, Inc. | Approval per use implanted neurostimulator |
| US8494641B2 (en) | 2009-04-22 | 2013-07-23 | Autonomic Technologies, Inc. | Implantable neurostimulator with integral hermetic electronic enclosure, circuit substrate, monolithic feed-through, lead assembly and anchoring mechanism |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1196150B (en) * | 1984-06-19 | 1988-11-10 | Poli Ind Chimica Spa | DERIVATIVES OF 1- (BIS- (4-FLUOROFENIL) METHYL) -4- (3-FENYL-2-PROPENYL) -HESHYDRO-1H-1,4-DIAZEPIN ACTIVATED CALCIUM ANTAGONIST, ITS PREPARATION AND COMPOSITIONS THAT CONTAIN IT |
| US5028610A (en) * | 1987-03-18 | 1991-07-02 | Sankyo Company Limited | N-benzhydryl-substituted heterocyclic derivatives, their preparation and their use |
| US4829065A (en) * | 1987-04-24 | 1989-05-09 | Syntex Pharmaceuticals, Ltd. | Substituted imidazolyl-alkyl-piperazine and -diazepine derivatives |
| US4826844A (en) * | 1987-09-30 | 1989-05-02 | American Home Products Corporation | Substituted 1-(aralkyl-piperazinoalkyl) cycloalkanols |
| GB9202238D0 (en) * | 1992-02-03 | 1992-03-18 | Wellcome Found | Compounds |
| MY111348A (en) * | 1993-07-30 | 1999-11-30 | Ardent Pharmaceuticals Inc | Opioid diarylmethylpiperazines and piperidines |
-
1995
- 1995-12-22 SE SE9504662A patent/SE9504662D0/en unknown
-
1996
- 1996-12-09 ZA ZA9610355A patent/ZA9610355B/en unknown
- 1996-12-11 EE EE9800195A patent/EE9800195A/en unknown
- 1996-12-11 IL IL12499796A patent/IL124997A0/en unknown
- 1996-12-11 AU AU12163/97A patent/AU706436B2/en not_active Ceased
- 1996-12-11 PL PL96327538A patent/PL327538A1/en unknown
- 1996-12-11 SK SK819-98A patent/SK81998A3/en unknown
- 1996-12-11 EP EP96943427A patent/EP0873322A1/en not_active Withdrawn
- 1996-12-11 TR TR1998/01184T patent/TR199801184T2/en unknown
- 1996-12-11 CZ CZ981767A patent/CZ176798A3/en unknown
- 1996-12-11 CN CN96180098A patent/CN1209126A/en active Pending
- 1996-12-11 WO PCT/SE1996/001636 patent/WO1997023467A1/en not_active Application Discontinuation
- 1996-12-11 TW TW085115322A patent/TW360641B/en active
- 1996-12-11 BR BR9612206A patent/BR9612206A/en unknown
- 1996-12-11 KR KR1019980704758A patent/KR19990076649A/en not_active Application Discontinuation
- 1996-12-11 JP JP09523558A patent/JP2000502680A/en active Pending
- 1996-12-11 NZ NZ324888A patent/NZ324888A/en unknown
- 1996-12-11 CA CA002239162A patent/CA2239162A1/en not_active Abandoned
- 1996-12-11 HU HU9900105A patent/HUP9900105A3/en unknown
-
1998
- 1998-06-10 IS IS4768A patent/IS4768A/en unknown
- 1998-06-19 NO NO982863A patent/NO982863L/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| SE9504662D0 (en) | 1995-12-22 |
| MX9804797A (en) | 1998-10-31 |
| KR19990076649A (en) | 1999-10-15 |
| AU706436B2 (en) | 1999-06-17 |
| PL327538A1 (en) | 1998-12-21 |
| HUP9900105A2 (en) | 1999-04-28 |
| ZA9610355B (en) | 1997-06-23 |
| NO982863D0 (en) | 1998-06-19 |
| EP0873322A1 (en) | 1998-10-28 |
| NO982863L (en) | 1998-06-19 |
| TR199801184T2 (en) | 1998-09-21 |
| EE9800195A (en) | 1998-12-15 |
| IL124997A0 (en) | 1999-01-26 |
| HUP9900105A3 (en) | 2000-05-29 |
| JP2000502680A (en) | 2000-03-07 |
| SK81998A3 (en) | 1998-11-04 |
| IS4768A (en) | 1998-06-10 |
| NZ324888A (en) | 1999-01-28 |
| AU1216397A (en) | 1997-07-17 |
| CN1209126A (en) | 1999-02-24 |
| BR9612206A (en) | 1999-07-13 |
| CA2239162A1 (en) | 1997-07-03 |
| CZ176798A3 (en) | 1998-09-16 |
| WO1997023467A1 (en) | 1997-07-03 |
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