TW202446264A - Composition for enhancing insecticidal effect and method for enhancing insecticidal effect - Google Patents

Abstract

The present invention provides a composition for enhancing the effect of an insecticide on insects that have developed resistance to the insecticide and a method for enhancing the effect. A composition for enhancing the effect of an insecticide is a composition for enhancing the effect of an insecticide on insects that have developed resistance to the insecticide, and is characterized by containing acetic acid fatty acid glyceride as an active ingredient.

Description

Composition for enhancing insecticidal effect and method for enhancing insecticidal effect

The present invention relates to the control of pests that have developed resistance to pesticides.

Acetic acid glycerol is used as a food additive in a wide range of foods such as chewing gum, waffle powder, and bread, and has been recognized in countries around the world. On the other hand, it is known that although it has no direct insecticidal effect on winged pests such as whiteflies and tea green leaf cicadas, it has a so-called behavioral control effect such as a repellent effect, a sap-sucking inhibitory effect, a mating inhibitory effect, and even a spreading effect on adult winged pests.

Patent Document 1 describes a winged insect repellent containing at least one selected from fatty acid glycerides, fatty acid sorbitan esters, acetylated monoglycerides, organic acid monoglycerides, fatty acid propylene glycol esters, polyoxyethylene sorbitan, fatty acids, sucrose fatty acid esters, sorbitan and soybean oil fatty acid methyl esters as an active ingredient, and a winged insect repellent method using the same. However, there is no description that acetylated fatty acid glycerides enhance the insecticidal effect on insecticide-resistant pests.

Patent Document 2 describes a composition comprising (a) acetic acid glyceride and (b) a specific insecticidal compound, and a method of applying the composition to crops to inhibit infection by plant viruses transmitted by winged pests. However, there is no description that acetic acid glyceride enhances the insecticidal effect against insecticide-resistant pests.

Patent document 3 discloses that a specific glycol ether compound is also specifically effective against the pyrethrin-sensitive house mosquito, and that this effect can be used as a countermeasure for reduced sensitivity, but there is no record of acetic acid glyceryl. Non-patent document 3 describes the effect of combining acetic acid glyceryl with flunilide or cyclohexanil on tea green leaf cicada. [Prior art document] [Patent document]

[Patent Document 1] International Publication No. 2006/028170 [Patent Document 2] International Publication No. 2015/147263 [Patent Document 3] International Publication No. 2020/039910 [Non-patent Document]

[Non-patent document 1] Ozawa Akira and 3 others, (2009) Journal of Kanto Higashiyama Pest Research Association, Vol. 56, pp. 107-109 [Non-patent document 2] Yamashita Koji and 2 others, (2011) Kansai Pest Research Association, Vol. 53, pp. 95-97 [Non-patent document 3] Gao Anfan and 4 others, (2023) Proceedings of the 67th Meeting of the Japan Society for Applied Zoology and Entomology, p. 89

[The problem that the invention is trying to solve]

Most current insecticides have the problem of reduced insecticide efficacy due to the presence of pests that have developed resistance (Non-patent Document 1, Non-patent Document 2). Literature reports many cases of resistance to insecticides being passed down from one generation to the next, and the spread of pesticides is difficult to control at the work site, with little recovery of sensitivity. In addition, insecticides with the same mechanism of action also show cross-resistance, which has become a serious problem. On the other hand, as a control measure for pests with developed resistance, the MODE OF ACTION CLASSIFICATION SCHEME of various insecticides published by IRAC (Insecticide Resistance Action Committee) has been gradually used to recommend the rotation control or mixed use of insecticides with different action mechanisms. However, with the exception of some exceptions such as insecticides with new action mechanisms, most insecticides have pests that have acquired a certain degree of resistance, so relying solely on rotation control may not be enough, and a more effective control measure is needed. [Means for solving the problem]

The inventors of the present invention have repeatedly studied and examined to solve the above-mentioned problems, and as a result, have found that if a composition characterized by containing acetic acid glyceride as an active ingredient is combined with an insecticide, the insecticidal effect on pests that have developed resistance to the insecticide will be significantly improved, and have completed the present invention.

That is, the present invention relates to a composition for enhancing insecticidal effect (hereinafter simply described as a composition for enhancing insecticidal effect), which is a composition for enhancing the effect of an insecticide on pests that may develop resistance to the insecticide depending on the circumstances, and is characterized by containing acetic acid fatty acid glyceride as an active ingredient. In addition, the present invention relates to a method for enhancing the insecticidal effect on pests that develop resistance to the insecticide using acetic acid fatty acid glyceride and an insecticide. In addition, the present invention also relates to a method for controlling pests that have developed resistance to pesticides, characterized in that acetic acid glyceride and an insecticide are applied to the pests that have developed resistance to the insecticide, the habitat of the pest, or the plant or the soil in which the plant is cultivated. In addition, the present invention relates to a combination for enhancing the effect of an insecticide on the pests that have developed resistance to the insecticide (hereinafter simply described as a combination), characterized in that it contains acetic acid glyceride and an insecticide. In addition, the present invention relates to a mixture (hereinafter simply described as a mixture) for enhancing the effect of an insecticide on pests that have developed resistance to the insecticide, characterized in that it contains acetic acid fatty acid glyceride and an insecticide as active ingredients. In addition, the present invention relates to an insecticide composition (hereinafter simply described as an insecticide composition), which is a composition in which the effect of an insecticide on pests that have developed resistance to the insecticide is enhanced, characterized in that it contains acetic acid fatty acid glyceride and an insecticide as active ingredients. [Effects of the invention]

By combining a composition for enhancing insecticidal effect with an insecticide, wherein the composition contains acetic acid glyceride as an active ingredient, a high insecticidal effect can be obtained for pests that have developed resistance to the insecticide. In addition, by combining a composition for enhancing insecticidal effect with an insecticide, wherein the composition contains acetic acid glyceride as an active ingredient, an effect of controlling pests that have developed resistance to the insecticide can be obtained in the growth place of the pest, the plant that grows the pest, and the cultivation soil of the plant. This control means a state where no pests exist in the aforementioned growth place, plant, or cultivation soil, or a state where the number of existing pests is reduced.

Acetyl fatty acid glyceride includes compounds represented by formula (I):

[In the formula, l is an integer of 0 to 16, m is an integer of 0 to 16, n is an integer of 0 to 16, and one or both of l, m, and n are 0 (except the case where all of l, m, and n are 0)] In formula (I), compounds in which one or both of l, m, and n are 0 are preferred, compounds in which one or both of l, m, and n are 0 and the remaining one is 6 to 16 are more preferred, and compounds in which one or both of l, m, and n are 0 and the remaining one is 10 and diethyl monolaurin are particularly preferred.

Insecticides applicable to the present invention include carbamate-based acetylcholine esterase inhibitors, organophosphorus-based acetylcholine esterase inhibitors, cyclic diene organochloride-based GABA (Gamma-Amino Butyric Acid)-gated chloride channel blockers, phenylpyrazole-based GABA-gated chloride channel blockers, pyrethrin-based or pyrethrin-based sodium channel modulators, neonicotinoid-based nicotinoid acetylcholine receptor competitive modulators, sulfonimide-based nicotinoid acetylcholine receptor competitive modulators, butenolide-based nicotinoid acetylcholine receptor competitive modulators, mediator-based nicotinoid acetylcholine receptor Choline receptor competitive modulators, pyridine subunit-based nicotinic acetylcholine receptor competitive modulators, spinosyn-based nicotinic acetylcholine receptor allosteric modulators (site I), avermectin-based or pulsatile glutamine-gated chloride channel allosteric modulators, juvenile hormone analogs, juvenile hormone-like preparations, pyridine azomethine derivatives, chord organ TRPV (Transient Receptor Potential Vanilloid) channel modulators, pyropene-based chord organ TRPV channel modulators, acting on CHS1 (Chitin Synthase 1) Mite growth inhibitors, mitochondrial ATP synthase inhibitors, oxidative phosphorylation uncouplers that interfere with proton gradients, sandworm toxin analogs, nicotinic acetylcholine receptor channel blockers, benzoylurea-based chitin synthesis inhibitors acting on CHS1, chitin synthesis inhibitor type 1, desquamation inhibitors, Diacylhydrazine-based exfoliating hormone receptor agonists, octopamine receptor agonists, mitochondrial electron transport chain complex III inhibitors (Qo site), mitochondrial electron transport chain complex I inhibitors, oxadiazine-based potential-dependent sodium ion channel blockers, semicarbazine-based potential-dependent sodium ion channel blockers, tetronic acid and tetramic acid derivatives of acetyl coenzyme A carboxylase inhibitors, β-keto derivatives of mitochondrial electron transport chain complex II inhibitors, anilide-based mitochondrial electron transport chain complex II inhibitors, diamide-based lanodine receptor modulators, chord organ modulators, meta-diamide-based GABA-gated chloride channel isosteres Regulators, isoxazoline GABA-gated chloride channel allosteric modulators, calcium-activated potassium channel modulators, mitochondrial electron transport chain complex III inhibitors (Qi site), azadirachtin, cypermethrin, pyrazolamide (Benzpyrimoxan), neomiticide, trifluoromethylpyrifos and cypermethrin, etc.

Specific examples of the above-mentioned insecticides are disclosed below. Carbamate-based acetylcholine esterase inhibitors include chloranil, demecarb, chloranil, chloranil, chloranil, chloranil, butyl ...

Organophosphorus acetylcholine esterase inhibitors include chlorfenapyr, chlorfenapyr, ethyl glutathione, methyl glutathione, cadusofos, chloroxyfos, chlorfenapyr, chlormethione, tausone, methyl tausone, coumaphos, cyanamide, chlorfenapyr, dalipine, dichloroacetate/DDVP, dimethoate, chlorfenapyr, methyl chlorfenapyr, dithiocarb, EPN, chlorfenapyr, chlorfenapyr, amoxicillin, fenmethoate, fenmethoate, forsaken, feidason, new nicotinoids, chlorfenapyr, isopropyl O-( Methoxyaminothiophosphoryl) salicylate, gafosone, marathon, megason, damason, meidason, mevenson, asulin, nelison, beimison, medoson, parathion, methylparathion, cedazon, fureson, yubison, imison, fusimethasone, bassacone, ateson, bufeisong, podason, puliosone, bakson, bifensong, bayusong, sulfotep, butylpirimiphos, apetosone, tofosong, lebensone, thiomethasone, trilosone, triclosan and fenmethasone, etc.

Cyclic organochlorine dienes are GABA-gated chloride channel blockers, including chlordane, chlorpheniramine and dichlorvos.

Phenylpyrazoles are GABA-gated chloride channel blockers, including escitalopram, fipronil, butyric acid, fluazifop and pyraclostrobin.

Pyrethrin-like or pyrethrin-based sodium ion channel modulators include ananine, alenine, d-cis/trans-alenine, d-trans-alenine, bifenine, berylline, berylline S-cyclopentenyl isomer, berylline, cypermethrin, cypermethrin, β-cyperine, serronine, λ-serronine, γ-serronine, serronine, methionine, β-methionine, θ-methionine, ζ-methionine, methionine [(1R)-trans isomer [(1R)-isomer], dimethoate, ibendin [(EZ)-(1R)-isomer], yihuali, eifenning, fenpurning, fenhuali, husaining, fluchlorfenapyr, τ-fuhuali, hefenning, iprenin, thiamethoxam, bamethoate, phenbutazone [(1R)-trans isomer], puyalenin, pyrethrin, resmethrin, silfufen, taifuning, zhimianning, zhimianning [(1R)-isomer], taimianning, baifuning and tetrafluthrin, etc.

Neonicotinoids are competitive modulators of nicotinoid acetylcholine receptors, which include sulfamethoxazole, clothianidin, furoatenimid, idarucizumab, nipyram, sirox, and sirox.

Sulfonimide is a nicotinic acid type acetylcholine receptor competitive modulator, and examples include sulfaquinoxaline and fluazifop.

Butenolide is a nicotinoid-type acetylcholine receptor competitive modulator, and examples include flupyralidone.

Ionic nicotine-type acetylcholine receptor competitive modulators include flumethacin and diclofenac.

Pyridine subunits are competitive modulators of nicotinoid-type acetylcholine receptors, examples of which include Flupyrimin.

Spinosyn is a nicotine-type acetylcholine receptor allosteric modulator (site I), which includes spinostat and spinosad.

Avermectin or avermectin-based glutamine-gated chloride channel allosteric regulators include abatin, emeticin benzoate, lepidomectin, mitramectin and ivermectin.

Juvenile hormone analogs include fenpropimorph, fenpropimorph and mefenamic acid.

Examples of juvenile hormone-like preparations include Fenox and Peripfen.

Pyridine azomethine derivatives are chord organ TRPV channel modulators, and examples include Paimiejing and Pyrifoquinazole.

Pyropene is a TRPV channel regulator of the chord organ, and examples include afuping.

Mite growth inhibitors that act on CHS1 include miticide, chlorfenapyr, cypermethrin and fluazifop, etc.

Mitochondrial ATP synthase inhibitors include Fenlon, Fenprodil and Dextran.

Oxidative phosphorylation uncouplers that interfere with the proton gradient include clovastatin and flubendiamide.

Examples of nicotinoid-type acetylcholine receptor channel blockers that are analogs of sandworm toxin include mesotrione, pediatric hydrochloride, thiophanate-methyl and chloranil monosodium.

Benzyl urea is a type of chitin biosynthesis inhibitor that acts on CHS1, and examples thereof include cloforan, diflubenzuron, diflubenzuron, flufenuron, flufenuron, hexaflum, lufenuron, novalon, novalon, deflum and triflum.

Chitin biosynthesis inhibitor type 1 includes bufenac and the like.

Exfoliation inhibitors (Diptera) include cyclopropylamine etc.

Diacylhydrazide is an exfoliating hormone receptor agonist, and examples include Mefenox, Cofenox, Hefenlon and Defenox.

Octopamine receptor agonists include three mites, etc.

Mitochondrial electron transport chain complex III inhibitors (Qo site) include imipenem, quinone mite, pyrimidine and bispyribac.

Mitochondrial electron transport chain complex I inhibitors include bisoprolol, fenpropimorph, defenadine, defenadine and bisoprolol.

Oxadiazines are potential-dependent sodium ion channel blockers, an example of which is Inderak.

Semi-carbohydrazone series potential-dependent sodium ion channel blockers include meflunisal and the like.

Tetronic acid and tetramic acid derivatives acetyl coenzyme A carboxylase inhibitors include Cipafen, Cimifen, Cipaidi and Cipaimie.

β-keto derivative mitochondrial electron transport chain complex II inhibitors include sepfen and sepfen mite.

Anilides are inhibitors of mitochondrial electron transport chain complex II, and examples thereof include Pyflubumide.

Diamide is a type of lanolin receptor modulator, which includes chloranil, cycloheximide, cyfluthrin, fluazifop, chloranil, tetrachlorvinamide, thiophanate-methyl, etc.

String organ regulators include flunamide and the like.

Meta-diamides are GABA-gated chloride channel allosteric modulators, including bromofenac and piperfuranilide.

Isoxazolines are GABA-gated chloride channel allosteric modulators, and examples thereof include fluoxatrimide, isoxazoline, and isoflualanam.

Calcium-activated potassium channel regulators include Acynonapyr and the like.

Mitochondrial electron transport chain complex III inhibitors (Qi site) include flumetoquine and the like.

Other compounds include azadirachtin, benzopyrimoxan, neochlorin, trifluoromethylpyrifos, sulfiflumin, fluazifop, etc.

The aforementioned insecticide may be in the form of a salt. The salt is not particularly limited as long as it is agriculturally acceptable, and examples thereof include alkali metal salts such as sodium salts and potassium salts; alkali earth metal salts such as magnesium salts and calcium salts; ammonium salts such as monomethylammonium salts, dimethylammonium salts, and triethylammonium salts; inorganic acid salts such as hydrochlorates, perchlorates, sulfates, and nitrates; and organic acid salts such as acetates, fumarates, and methanesulfonates.

In the present invention, the mixing ratio of acetic fatty acid glyceride to the insecticide (active ingredient) is not particularly limited, and is generally 1:100000 to 100000:1 by weight, preferably 1:10000 to 10000:1, more preferably 1:1000 to 1000:1, more preferably 80:1 to 3:1, and particularly preferably 45:1 to 3:1.

In the present invention, acetic acid glycerol and the insecticide may be used in the form of separately prepared preparations or in the form of commercial preparations. In addition, in the present invention, a preparation prepared by preparing acetic acid glycerol and the insecticide (its active ingredient) together may be used. The above-mentioned preparation may be mixed with various preparation auxiliary components to prepare preparations in various forms such as emulsions, powders, granules, hydrates, granular hydrates, aqueous suspensions, oily suspensions, liquids, aerosols, pastes, etc., as long as it is suitable for the purpose of the present invention, as in the case of conventional pesticide preparations. The blending ratio relative to the whole preparation is usually 0.001 to 99 parts by weight of acetic acid glyceride and/or insecticide (hereinafter simply recorded as the active ingredient) and 1 to 99.999 parts by weight of the preparation auxiliary component, preferably 0.01 to 95 parts by weight of the preparation auxiliary component and 5 to 99.99 parts by weight of the preparation auxiliary component, and more preferably 0.01 to 80 parts by weight of the preparation auxiliary component and 20 to 99.99 parts by weight of the preparation auxiliary component. When these preparations are actually used, they can be used directly or diluted with a diluent such as water to a predetermined concentration.

The auxiliary agents used in the preparations include kaolin, sericite, diatomaceous earth, slaked lime, calcium carbonate, talc, white carbon, kaolin, bentonite, clay, sodium carbonate, sodium bicarbonate, sodium sulfate, zeolite, solid carriers such as starch; such as water, toluene, xylene, solvent oil, dioxane, dimethyl sulfoxide, N,N-dimethylformamide, dimethylacetamide, N-methyl-2-pyrrolidone, alcohol-like solvents; fatty acid salts, benzoic acid salts, polycarboxylates, alkyl sulfate esters, alkyl sulfates, alkyl aromatic Sulfates, alkyl diglycol ether sulfates, alcohol sulfates, alkyl sulfonates, alkyl aromatic sulfonates, aromatic sulfonates, lignin sulfonates, alkyl diphenyl ether disulfonates, polystyrene sulfonates, alkyl phosphates, alkyl aromatic phosphates, styrene aromatic phosphates, polyoxyethylene alkyl ether sulfates, polyoxyethylene alkyl aromatic ether sulfates, polyoxyethylene alkyl aromatic ether sulfates, polyoxyethylene alkyl ether phosphates, polyoxyethylene alkyl aromatic phosphates, polyoxyethylene aromatic ether phosphoric acid anionic surfactants such as salts of esters of naphthalenesulfonic acid formalin condensates and alkylnaphthalenesulfonic acid formalin condensates; fatty acid anhydrous sorbitan esters, diglycerides, triglycerides, fatty acid polyglycerol esters, fatty acid alcohol polyglycol ethers, acetylene glycol, acetylene alcohol, oxyalkylene block polymers, polyoxyethylene alkyl ethers, polyoxyethylene alkyl aromatic ethers, polyoxyethylene styrene aromatic ethers, polyoxyethylene glycol alkyl ethers, polyethylene glycol, fatty acid polyoxyethylene esters, fatty acid polyoxyethylene anhydrous sorbitan Non-ionic surfactants such as alcohol esters, polyoxyethylene glycerol fatty acid esters, polyoxyethylene hardened castor oil, and polyoxypropylene fatty acid esters; vegetable oils such as olive oil, kapok seed oil, castor oil, palm oil, camellia oil, coconut oil, sesame oil, corn oil, rice bran oil, peanut oil, cottonseed oil, soybean oil, rapeseed oil, linseed oil, and tung oil, and alkylated vegetable oils (methylated rapeseed oil, ethylated rapeseed oil, methylated soybean oil, etc.); mineral oils such as liquid paraffin, paraffin oil, tablet oil, and naphtha, etc.

The application in the present invention can be carried out by a commonly used application method, such as spreading (e.g., spraying, atomization, pulverization, granulation, water surface application, etc.), soil spreading (mixing, pouring, etc.), surface application (painting, powder coating, covering, etc.), etc. In addition, application using an aerial device such as a drone or an unmanned helicopter, or application by the so-called ultra-low volume method. When applying, it can be arbitrarily selected to apply to pests, places where pests live (before or after the emergence of the pests), plants, or plant cultivation soils. Acetic acid fatty acid glyceride and the insecticide can be mixed in preparations prepared separately at the time of application, or a preparation prepared by combining the two can be applied. The prepared preparation can be applied directly or diluted with water or the like.

The application amount of the composition for enhancing the insecticidal effect of the present invention and the insecticide varies according to meteorological conditions, target crops, application methods, formulation forms, etc., and cannot be determined in general. For example, when applied to the stems and leaves of plants, the total concentration of acetic fatty acid glyceride as an effective ingredient of the composition for enhancing the insecticidal effect and the insecticide (insecticide effective ingredient) is usually 0.1 to 100,000 ppm, preferably 1 to 10,000 ppm, and more preferably 1 to 1,000 ppm. When applied to soil, the total amount of acetic acid glycerol and the insecticide (insecticide active ingredient) is usually 0.1 to 100,000 g/ha, preferably 1 to 10,000 g/ha, and more preferably 10 to 1,000 g/ha. When applied to aquatic pests, the total amount of acetic acid glycerol and the insecticide (insecticide active ingredient) is usually 0.1 to 100,000 g/ha, preferably 1 to 10,000 g/ha, and more preferably 10 to 1,000 g/ha. When applied to seeds, the total amount of acetic fatty acid glyceride and the insecticide (insecticide active ingredient) is usually 0.01-10000 g/100 kg of seeds, preferably 0.1-1000 g/100 kg of seeds, and more preferably 1-1000 g/100 kg of seeds.

In the present invention, in addition to acetic acid fatty acid glyceride and insecticides, other pesticides, fertilizers, pesticide-damage reducing agents, etc. can also be mixed or used in combination. In this case, more excellent effects and properties can be shown. Other pesticides include herbicides, fungicides, antivirals, attractants, plant hormones, plant growth regulators, biological pesticides, etc.

The combination, mixture and insecticidal composition of the present invention are effective for controlling the following pests with developed resistance.

Hemiptera: Leaf cicadas (Cicadellidae) such as the electric leaf cicada (Recilia dorsalis), the black-striped black-tailed leaf cicada (Nephotettix nigropictus), the potato leaf cicada (Empoasca fabae), the large white leaf cicada (Cofana spectra), the Taiwanese leaf cicada (Nephotettix virescens), the tea leaf cicada (Empoasca onukii, Empoasca vitis), the false black-tailed leaf cicada (Nephotettix cincticeps), the two-spotted leaf cicada (Amrasca biguttula), the corn leaf cicada (Dalbulus maidis), the grape leaf cicada (Erythroneura vitis), and the beet leaf cicada (Circulifer tenellus); the Palearctic fly lice (Javesella Delphacidae, including the sugarcane flat-horned fly (Perkinsiella saccharicida), the white-backed fly (Sogatella furcifera), the corn fly (Peregrinus maidis), the brown fly (Nilaparvata lugens), the gray fly (Laodelphax striatellus), and the rice fly (Tagosodes orizicolus); Aleyrodidae, including the greenhouse powder fly (Trialeurodes vaporariorum), the tobacco powder fly (Bemisia tabaci), the tea powder fly (Aleurocanthus camelliae), the ash powder fly (Pealius euryae), the citrus powder fly (Dialeurodes citri), and the citrus powder fly (Aleurocanthus spiniferus); and Acyrthosiphon pisum), Tetraneura nigriabdominalis, Ceratovacuna lanigera, Aulacorthum solani, Brevicoryne brassicae, Aphis glycines, Macrosiphum euphorbiae, Rhopalosiphum maidis, Lipaphis erysimi, Melanaphis sacchari, Aphis fabae, Toxoptera citricida, Rhopalosiphum padi, Brachycaudus helichrysi, Myzus persicae, Hyalopterus pruni, Aphis spp. spiraecola), Eriosoma lanigerum, Nasonovia ribisnigri, Aphis gossypii, Aphis pomi, Sitobion avenae, Dysaphis plantaginea, etc.; Phylloxeridae, Daktulosphaira vitifoliae, Phylloxera notabilis, Phylloxera devastatrix, Phylloxera russelae, etc.; Hemlock aphids, Aphrastasia pectinatae, Adelges tsugae, etc. piceae, etc.; Aphrophoridae, such as Philaenus spumarius; Cercopidae, such as Mahanarva fimbriolata; Nezara antennata, Scotinophara lurida, Eysarcoris lewisi, Halyomorpha halys, Eysarcoris ventralis, Plautia stali, Eysarcoris aeneus, Nezara viridula, Eysarcoris annamita, Scotinophara lurida, Eysarcoris ventralis ... coarctata), soybean brown stink bug (Euschistus heros), green-bellied stink bug (Dichelops melacanthus), red-banded stink bug (Piezodorus guildinii), rice stink bug (Oebalus pugnax), etc.; soil bugs (Cydnidae) such as chestnut soil bug (Scaptocoris castanea), spider bugs (Alydidae) such as rice edge bug (Leptocorisa chinensis), spider edge bug (Leptocorisa acuta), bee edge bug (Riptortus clavatus), etc.; edge bugs (Coreidae) such as leaf-footed edge bug (Leptoglossus australis), rice thorn edge bug (Cletus punctiger), etc.; wheat long bug (Blissus leucopterus), Cavelerius saccharivorus, Togo hemipterus, etc.; Miridae, including Stenotus rubrovittatus, Trigonotylus caelestialium, Lygus lineolaris, Lygus rugulipennis, Stenodema calcarata, etc.; Aonidiella aurantii, Pseudaulacaspis prunicola, Pseudaulacaspis pentagona), Abgrallaspis cyanophylli, Diaspidiotus perniciosus, Unaspis yanonensis, etc.; Coccidae, Ceroplastes rubens, etc.; Margarodidae, Icerya purchasi, Icerya seychellarum, etc.; Pseudococcus calceolariae, Phenacoccus spp. solenopsis), Pseudococcus comstocki, Pseudococcus longispinus, Phenacoccus solani, Planococcus kraunhiae, Planococcus citri, Brevennia rehi, etc.; Bactericera cockerelli, Cacopsylla chinensis, Cacopsylla pyrisuga, Diaphorina citri, Trioza erytreae), Cacopsylla pyricola, etc.; Tingidae, such as Corythucha marmorata, Stephanitis pyrioides, Stephanitis nashi, Corythucha ciliata, etc.; Cicadae, such as Quesada gigas, etc.

Lepidoptera: Ostrinia scapulalis, Ostrinia furnacalis, Scirpophaga incertulas, Marasmia exigua, Cnaphalocrocis medinalis, Pediasia teterrellus, Chilo suppressalis, Hellula undalis, Herpetogramma luctuosale, Notarcha derogata, Chilo polychrysus, Nymphula depunctalis, Scirpophaga innotata, Diatraea sutchuenensis saccharalis), Leucinodes orbonalis, Ostrinia nubilalis, Rupela albina, Marasmia patnalis, etc.; Pyralidae, Ephestia kuehniella, Cadra cautella, Plodia interpunctella, Euzophera batangensis, Elasmopalpus lignosellus, etc.; Spodoptera exempta, Mythimna separata, Plusia festucae, Sesamia inferens, Spodoptera exigua, etc. exigua), Spodoptera mauritia, Autographa nigrisigna, Agrotis ipsilon, Spodoptera frugiperda, Heliothis virescens, Spodoptera litura, Naranga aenescens, Mamestra brassicae, Spodoptera eridania, Chrysodeixis includens, Spodoptera cosmioides, Trichoplusia spp., Helicoverpa zea, Helicoverpa armigera, Trichoplusia ni, Agrotis segetum), Spodoptera depravata, Helicoverpa assulta, Aedia leucomelas, Sesamia calamistis, Alabama argillacea, Hydraecia immanis, Pseudoplusia includens, Anticarsia gemmatalis, etc.; Pieridae, Pieris brassicae, Pieris rapae, etc.; Matsumuraeses azukivora, Archips xylosteanus, Tetramoera schistaceana), Cydia pomonella, Grapholita dimorpha, Adoxophyes honmai, Homona magnanima, Grapholita molesta, Leguminivora glycinivorella, Archips fuscocupreanus, Adoxophyes orana fasciata, Citripestis sagittiferella, Lobesia botrana, Epinotia aporema, etc.; Phyllonorycter ringoniella, Caloptilia theivora, Phyllocnistis citrella, etc.; Carposinidae, Carposina sasakii, etc.; Lyonetiidae, Lyonetia prunifoliella, Lyonetia clerkella, Leucoptera coffeella, etc.; Lymantriidae, Lymantria spp., Lymantria dispar, etc.; Euproctis spp., Euproctis pseudoconspersa, etc.; Helcystogramma triannulella, Plutella xylostella, etc. xylostella, etc.; Gelechiidae, such as Phthorimaea operculella, Tuta absoluta, Anarsia lineatella, Pectinophora gossypiella, etc.; Arctiidae, such as Hyphantria cunea, etc.; Castniidae, such as Telchin licus, etc.; Cossidae, such as Cossus insularis, etc.; Geometridae, such as Cystidia couaggaria, Ascotis selenaria, etc.; Parasa consocia, Monema consocia, etc. flavescens, Parasa lepida, etc.; Stathmopodidae, Stathmopoda masinissa, etc.; Sphingidae, Acherontia lachesis, etc.; Sesiidae, Nokona feralis, Synanthedon hector, Synanthedon tenuis, etc.; Hesperiidae, Parnara guttata, etc.; Tineidae, Tinea translucens, Tineola bisselliella, etc.; Papilio xuthus, Papilio machaon, etc. hippocrates) and other Papilionidae.

Thysanoptera: Thripidae, including Stenchaetothrips biformis, Scirtothrips dorsalis, Thrips tabaci, Frankliniella intonsa, Frankliniella occidentalis, Frankliniella fusca, Thrips palmi, Echinothrips americanus, Megalurothrips sjostedti, Scirtothrips perseae, etc.; Phlaeothripidae, including Haplothrips aculeatus, etc.

Diptera: Anthomyiidae, such as Delia platura, Delia antiqua, Pegomya cunicularia; Ulidiidae, such as Tetanops myopaeformis; Agromyzidae, such as Agromyza oryzae, Liriomyza sativae, Chromatomyia horticola, Liriomyza chinensis, Liriomyza trifolii; Rice fly (Chlorops oryzae) and other fruit flies (Chloropidae); fruit flies (Tephritidae) such as Bactrocera cucurbitae, Rhacochlaena japonica, Bactrocera oleae, Bactrocera tryoni, Ceratitis capitata, Bactrocera latifrons, Bactrocera dorsalis, and Rhagoletis pomonella; rice black stem fly (Hydrellia sasakii), rice leaf fly (Hydrellia griseola), Philippine hairy eye fly (Hydrellia philippina) and other Ephydridae; Drosophila suzukii, Drosophila melanogaster and other fruit flies (Drosophilidae); Megaselia spiracularis and other flea flies (Phoridae); Clogmia albipunctata and other moth flies (Psychodidae); Bradysia difformis and other fungus flies (Sciaridae); Orseolia oryzae, Mayetiola destructor and other gall flies (Cecidomyiidae); Diopsis macrophthalma) and other Diopsidae.

Coleoptera: Dicladispa armigera, Oulema oryzae, Aulacophora femoralis, Phyllotreta striolata, Oulema melanopus, Leptinotarsa decemlineata, Chaetocnema confinis, Diabrotica undecimpunctata howardi, Epitrix hirtipennis, Laccoptera quadrimaculata, Diabrotica balteata, Cerotoma trifurcata, Psylliodes chrysocephala), corn flea beetle (Chaetocnema pulicaria), radish flea beetle (Phyllotreta cruciferae), South American leaf beetle (Diabrotica speciosa), grape sheath leaf beetle (Colaspis brunnea), hop flea beetle (Psylliodes punctulata), northern corn rootworm (Diabrotica barberi), potato flea beetle (Epitrix cucumeris), southern corn leaf beetle (Myochrous denticollis), western black flea beetle (Phyllotreta pusilla), western corn rootworm (Diabrotica virgifera virgifera), Mexican corn rootworm (Diabrotica virgifera zeae), etc.; corn seed beetle (Clivina impressifrons), corn seed beetle (Stenolophus lecontei) and other walking bugs (Carabidae); small bronze turtles (Anomala albopilosa), black turtles (Holotrichia spp.), black round turtles (Tomarus gibbosus), copper turtles (Anomala cuprea), brown long turtles (Heptophylla picea), copper turtles (Anomala rufocuprea), bean turtles (Popillia japonica), European turtles (Rhizotrogus majalis), hairy gill turtles (Phyllophaga crinita), six-gill turtles (Phyllophaga spp.), Argentine horned turtles (Diloboderus abderus) and other turtles (Scarabaeidae); coffee bean weevils (Araecerus coffeae, etc.; needle-mouthed weevils (Aponidae) such as the sweet potato ant weevil (Cylas formicarius), etc.; bean weevils (Bruchidae) such as the mung bean weevil (Callosobruchus chinensis) and the Brazilian bean weevil (Zabrotes subfasciatus); bark weevils (Scolytidae) such as the vertical pit cutter beetle (Tomicus piniperda) and the coffee berry beetle (Hypothenemus hampei); alfalfa weevils (Hypera postica), rice weevils (Echinocnemus squameus), rice water weevils (Lissorhoptrus oryzophilus), sweet potato weevils (Euscepes postfasciatus), grain weevils (Sitophilus granarius), corn weevils (Sitophilus zeamais), rice weevil (Sitophilus oryzae), rusty gourd beetle (Scepticus griseus), hunting beak beetle (Sphenophorus venatus), Asian palm weevil (Rhabdoscelus lineaticollis), iris gourd beetle (Scepticus uniformis), cotton bell weevil (Anthonomus grandis), cotton root borer (Eutinobothrus brasiliensis), southern corn weevil (Sphenophorus callosus), sugarcane weevil (Sphenophorus levis), Aracanthus mourei, soybean stem weevil (Sternechus subsignatus), etc.; foreign rice pseudo-walker (Alphitobius diaperinus), pseudo-grain thief (Tribolium castaneum), flat pseudo-grain thief (Tribolium confusum, etc.; Coccinellidae, such as Epilachna vigintioctomaculata and Epilachna vigintioctopunctata; Bostrychidae, such as Rhizopertha dominica and Lyctus brunneus; Ptinidae; Cerambycidae, such as Aromia bungii, Anoplophora malasiaca and Migdolus fryanus; Melanotus okinawensis, Melanotus legatus and Agriotes slenderbreasted; fuscicollis), Aeolus, Anchastus, Conoderus, Ctenicera, Limonius and other genera; Staphylinidae and other winged winged beetles; Dermestidae and other winged beetles; Stegobium paniceum and Lasioderma serricorne and other winged beetles; Cryptolestes and other winged flatworms. ferrugineus) and other flat beetles (Laemophloeidae); saw-breasted flour beetles (Oryzaephilus surinamensis) and other slender flat beetles (Silvanidae); pollen beetles (Brassicogethes aeneus) and other slender tail beetles (Nitidulidae).

Orthoptera: Nomadacris septemfasciata, Chortoicetes terminifera, Oxya yezoensis, Schistocerca gregaria, Patanga succincta, Locusta migratoria, Oxya japonica, Dociostaurus maroccanus, Locustana pardalina, Camnula pellucida, Melanoplus differentialis, Calliptamus italicus, Melanoplus sanguinipes, Melanoplus femurrubrum, Anacridium melanorhodon, Austracris guttulosa, Melanoplus bivittatus, Gastrimargus musicus, etc.; Gryllotalpidae, Gryllotalpa orientalis, etc.; Gryllidae, Teleogryllus emma, Acheta domestica, etc.; Tettigoniidae, Anabrus simplex, etc.

Acari: Oligonychus spp., such as Oligonychus aceris, Oligonychus ilicis, Oligonychus gossypii, Tetranychus kanzawai, Tetranychus urticae, Panonychus citri, Tetranychus evansi, Panonychus ulmi, etc.; Aceria diospyri, Shevtchenkella sp., Calacarus carinatus, Acaphylla theavagrans, Aculops lycopersici, Eriophyes chibaensis, Aculops pelekassi, Phyllocoptruta citri, Aculus schlechtendali, Aceria tosichella, etc.; Tarsonemidae, such as Polyphagotarsonemus latus; Tenuipalpidae, such as Brevipalpus phoenicis; Tuckerellidae; Argas persicus, Ornithodoros spp. hermsi, Ornithodoros turicata, etc., and mealybugs (Acaridae) such as Tyrophagus putrescentiae and Tyrophagus similis.

Among the above, it is particularly effective against potato leafhopper (Empoasca fabae), tea leafhopper (Empoasca onukii, Empoasca vitis), grape leafhopper (Erythroneura vitis), beet leafhopper (Circulifer tenellus), tobacco mealybug (Bemisia tabaci), western flower mites (Frankliniella occidentalis), two-spotted leaf mite (Tetranychus urticae), peach aphid (Myzus persicae), vegetable leaf miner (Liriomyza sativae), tea roller moth (Adoxophyes honmai), tea roller moth (Homona magnanima), diamondback moth (Plutella xylostella), etc.

Among the above, it is effective against Empoasca onukii, Bemisia tabaci, Frankliniella occidentalis, Tetranychus urticae, Myzus persicae, Liriomyza sativae, Adoxophyes honmai, Homona magnanima, Plutella xylostella, etc.

The combination, mixture and insecticide composition of the present invention can be used for rice, wheat, barley, rye, oats, sorghum, corn and other rice family; soybean, peanut, broad bean, pea, chickpea and other legume family; cucumber, pumpkin, watermelon, cantaloupe, comb melon and other cucurbit family; tomato, eggplant, green pepper, potato, pepper and other solanaceae family; cabbage, Chinese cabbage, white radish, turnip, broccoli, cauliflower, rapeseed and other cruciferae family; burdock, lettuce and other Asteraceae family; scallion, onion, asparagus and other herbs family. The family includes: sedum, carrot, parsley, etc.; Umbelliferae, such as carrots and parsley; Lamiaceae, such as perilla and mint; flowers, such as roses, chrysanthemums, carnations, and gerberas; fruit trees, such as grapes, apples, pears, citrus, peaches, plums, cherries, blueberries, and persimmons; trees, such as tea, coffee, cocoa, olives, and almonds; forage grasses, such as daffodils, Italian ryegrass, alfalfa, and clover; turf grasses, such as bentgrass and fine-leaved knotweed; and plants, such as cotton, bananas, ginger, strawberries, sweet potatoes, and beets. In addition, the aforementioned plants also include transgenic plants produced by genetic modification or gene editing technology. Examples of transformed plants include herbicide-tolerant transformed plants, pest-resistant transformed plants, plant component-related transformed plants, and plant pathogen-resistant transformed plants. In addition, there are stacked varieties that combine multiple of these useful traits.

The application to the aforementioned plants can be carried out on any part of the plants, such as leaves, stems, peduncles, flowers, flower buds, fruits, seeds, roots, tubers, and scales.

The following is an example of a desired aspect of the present invention, but the present invention is not limited to these examples. [1] A composition for enhancing insecticidal effect, which is a composition for enhancing the effect of an insecticide on pests that are resistant to the insecticide, characterized in that it contains acetic acid fatty acid glyceride as an active ingredient.

[2] A composition for enhancing insecticidal effect as described in [1], wherein the insecticide is selected from the group consisting of carbamate acetylcholine esterase inhibitors, organophosphorus acetylcholine esterase inhibitors, cyclic diene organochlorine GABA-gated chloride channel blockers, phenylpyrazole GABA-gated chloride channel blockers, Channel blockers, pyrethrin-like or pyrethrin-based sodium ion channel modulators, neonicotinoid-based nicotinoid acetylcholine receptor competitive modulators, sulfonimide-based nicotinoid acetylcholine receptor competitive modulators, butenolide-based nicotinoid acetylcholine receptor competitive modulators, mediators Nicotine-type acetylcholine receptor competitive modulators, pyridine subunit-based nicotinic acetylcholine receptor competitive modulators, spinosyn-based nicotinic acetylcholine receptor allosteric modulators (site I), avermectin-based or pulsatile glutamine-gated chloride channel allosteric modulators, juvenile hormone analogs, juvenile hormone-like preparations, pyridine azomethine derivatives chord organ TRPV channel modulators, pyropene-based chord organ TRPV channel modulators, mite growth inhibitors acting on CHS1, mitochondrial ATP synthase inhibitors, proton gradient interference Oxidative phosphorylation uncoupler, sandworm toxin analog nicotinic acetylcholine receptor channel blocker, benzoylurea-based chitin biosynthesis inhibitor acting on CHS1, chitin biosynthesis inhibitor type 1, desquamation inhibitor (Diptera), diacylhydrazine-based desquamation hormone receptor agonist , octopamine receptor agonists, mitochondrial electron transport chain complex III inhibitors (Qo site), mitochondrial electron transport chain complex I inhibitors, oxadiazine-based potential-dependent sodium ion channel blockers, semicarbazine-based potential-dependent sodium ion channel blockers, tetronic acid and tetramic acid At least one insecticide selected from the group consisting of derivative acetyl coenzyme A carboxylase inhibitors, β-keto derivative mitochondrial electron transport chain complex II inhibitors, anilide-based mitochondrial electron transport chain complex II inhibitors, diamide-based ranodine receptor modulators, chord organ modulators, meta-diamide-based GABA-gated chloride ion channel allosteric modulators, isoxazoline GABA-gated chloride ion channel allosteric modulators, calcium-activated potassium ion channel modulators, mitochondrial electron transport chain complex III inhibitors (Qi site), azadirachtin, trifluramide and cypermethrin.

[3] A composition for enhancing the insecticidal effect as described in [1] or [2], wherein the insecticide is selected from the group consisting of chloranil, chloranil, chloranil, butyl ... Dameisong, Pomeisong, Fusaide, Xinyanfophos, Jiafusong, Marathon, Damason, Mieda Song, Balason, Saidazon, Bufeisong, Prothiosone, Kochandane, Anzafan, Yispu, Fipronil, Butenyl Fipronil, Pyraclostrobin, Ananine, Bifennin, Cypermethrin, Siphonin, β-Siphonin, Sironin, γ- Cerionine, λ-Cerionine, Cerionine, Amidinine, β-Cerionine, θ-Cerionine, ζ-Cerionine, σ-Cerionine, Dimidinine, Efenin, Fenpurin, Fenhuali, Husienine, Flumethrin, Fuhuali, τ-Fuhuali, Permethrin, Sihufen, Taifuning, Tymidin, Trifluthrin, Pyrethrin , tetrafluthrin, methoxythrin, clothianidin, furoate, idarucizumab, nitramexam, segopet, seroquel, seroquel, flupyrimin, flumethopioid, diclofenac, flupyrimin, sinostat, sinomethoxazole, abatin, phentermine benzoate, lepidomicil, mitoxantrone, ivirtuin, sinomethoxazole, ivirtuin, sinomethoxazole, sinomethoxazole, tretinoin ... streptomycin, methoxyfenethyl, methoxyfenopyrin, mefenopyrin, fenoxac, belipfen, penicillin, pyrifoquinazole, afuping, edaphate, kefen mites, hesaduo, tafenron, mites multi, demit, kefanpai, flubendiamide, pedan hydrochloride, kefulong, diflubenzuron, diflunisal, flufenuron, flufenuron, hexaflumuron, Lufenlong, Novalon, Nofulong, Defulong, Sanfulong, Bufenjing, Miefno, Kefenno, Hefenlong, Defenno, Triamin, Aimeson, Subaquinone Mites, Fimfetil, Bifenmite, Bidaben, Fenpromite, Defenrui, Defenrui, Bitaifen, Indeke, Meflunomide, Cipafen, Cipafen, Cipaidi, Cipaime, Saifen At least one insecticide selected from the group consisting of: Pyfen, Cyfenamy, Pyflubumide, Cianbol, Cyclobromide, Cyanbol, Fludime, Teanbol, Chloroflucyranide, Tetrachloranide, Sulfocyclamide, Flunilide, Bromitriptyline, Piperfuranilide, Fluoxazolidinone, Isoflualanam, Acynonapyr, Flumetolquine, Benzpyrimoxan, Flumethoxan, Flufenamid, Sulfiflumin and Flufenamid.

[4] A composition for enhancing the insecticidal effect as described in [1] or [2], wherein the insecticide is selected from the group consisting of chloranil, chloranil, chloranil, chloranil, chloranil, chloranil, chloranil, chloranil, chloranil, chloranil, chloranil, chloranil, chloranil, chloranil, chloranil, chloranil, chloranil, chloranil, chloranil, chloranil, chloranil, chloranil, chloranil, chloranil, chloranil, chloranil, chloranil, chloranil, chloranil, chloranil, chloranil, chloranil, chloranil, chloranil, chloranil, chloranil, chloranil, chloranil, chloranil, chloranil, chloranil, chloranil, chloranil, chloranil, chloranil, chloranil, chloranil, chloranil, chloranil, chloranil, chloranil, chloranil, chloranil, chloranil, chloranil , Clonidin, Furoxamide, Idamine, Nipyram, Segope, Sesoan, Synote, Synosarc, Abatin, Inmetin Benzoate, Repimectin, Mimetin, Peripfen, Pyrifoquinazole, Ethiocarb, Taifenlon, Fenta, Dedecarb, Kefanpai, Pedan Hydrochloride, Kefulong, Difulong, Flufenol, Lufenol, Defulong, Bufenjing, Mifenol, Cofenno, Defenno, Quinone mites, Bifen mites, Bidaben, Fenpromide, Defenrui, Defenrui, Bitaifen, Sipaifen, Simeifen, Saipaifen, Saifen mites, Pyflubumide, Keanbo, Cyclobromofenamide, Saianbo, Fludime, Teanbo, Thiocyclamide, Fluniamide, Bromifenamide, Piperonyl furanamide (P At least one insecticide selected from the group consisting of iperfuranilide, fluoxazolidinone, isoflualanam, aceynonapyr, flumetoquine, benzopyrimoxan, trifluralin, fenthiocarbamide, sulfiflumin and flufenacet.

[5] The composition for enhancing the insecticidal effect of [1] or [2], wherein the insecticide is selected from the group consisting of chloranil, ... Ning, Fuhuali, Baimianning, Taifuning, Taimianning, pyrethrin, amine, clothianidin, furoate, idarucizumab, nitram, segope, seroquel, sinostat, sinoclase, abatin, entimin benzoate, lepidomectin, mitrin, belipfen, pyrimethamine, ethidium bromide, edimethion At least one insecticide selected from the group consisting of , tafenalon, cypermethrin, dextran, clofenpai, pedan hydrochloride, clofenalon, difuron, flufenalon, lufenalon, defuron, bufenjing, mefenno, kofenno, defenno, quinone mite, bifenmite, bidaben, fenpromite, defenrui, defenrui, bifenmite, sipefen, sipefen, sipefen, sipefen, pyflubumide, keanbo, cyclobromide, saianbo, fludime, teanbo, fluniamide, fluoxazolamide, aceynonapyr and flumetoquine.

[6] A composition for enhancing insecticidal effect as described in [1] or [2], wherein the insecticide is at least one insecticide selected from the group consisting of bifenthrin, furodiol, idarucizumab, senostat, senocid, abatin, pyrifoquinoxaline, clofenton, bufenac, fenpropathrin, defenrexate, cyproconazole, cycloheximide, cyproconazole, flunilide, and fluoxetine.

[7] The insecticide effect enhancing composition of [1] or [2], wherein the mixing ratio of acetic acid glyceride to the insecticide is 1:1000 to 1000:1 by weight. [8] The insecticide effect enhancing composition of [1] or [2], wherein the mixing ratio of acetic acid glyceride to the insecticide is 80:1 to 3:1 by weight. [9] The insecticide effect enhancing composition of [1] or [2], wherein the mixing ratio of acetic acid glyceride to the insecticide is 45:1 to 3:1 by weight.

[10] A method for enhancing the insecticidal effect of acetic acid glycerol and an insecticide on insects that have developed resistance to the insecticide. [11] A method for controlling insects that have developed resistance to insecticides, characterized in that acetic acid glycerol and an insecticide are applied to the insects that have developed resistance to the insecticide, the habitat of the insects, or the plants or soil in which the plants are cultivated.

[12] The method of [10] or [11], wherein the insecticide is selected from the group consisting of carbamate acetylcholine esterase inhibitors, organophosphorus acetylcholine esterase inhibitors, cyclic diene organochlorine GABA-gated chloride channel blockers, phenylpyrazole GABA-gated chloride channel blockers, Weaning agent, pyrethrin-like or pyrethrin-based sodium ion channel modulator, neonicotinoid-based nicotinoid acetylcholine receptor competitive modulator, sulfonimide-based nicotinoid acetylcholine receptor competitive modulator, butenolide-based nicotinoid acetylcholine receptor competitive modulator, meso-based nicotinoid Competitive modulators of acetylcholine receptors, competitive modulators of nicotinic acetylcholine receptors of pyridine subunits, allosteric modulators of nicotinic acetylcholine receptors of spinosyn series (site I), allosteric modulators of avermectin series or pleural venous glutamine-gated chloride ion channels, juvenile hormone analogs, juvenile hormone-like preparations, pyridine azomethine derivatives of chord organ TRPV channel modulators, pyropene chord organ TRPV channel modulators, mite growth inhibitors acting on CHS1, inhibitors of mitochondrial ATP synthase, oxygen that interferes with the proton gradient Phosphorylation uncoupler, sandworm toxin analog nicotinic acid type acetylcholine receptor channel blocker, benzoylurea-based chitin biosynthesis inhibitor acting on CHS1, chitin biosynthesis inhibitor type 1, desquamation inhibitor (Diptera), diacylhydrazine-based desquamation hormone receptor agonist, Octopamine receptor agonists, mitochondrial electron transport chain complex III inhibitors (Qo site), mitochondrial electron transport chain complex I inhibitors, oxadiazine-based potential-dependent sodium ion channel blockers, semicarbazine-based potential-dependent sodium ion channel blockers, tetronic acid and tetramonic acid derivatives At least one insecticide selected from the group consisting of bioacetyl coenzyme A carboxylase inhibitors, β-keto derivative mitochondrial electron transport chain complex II inhibitors, acylanilide-based mitochondrial electron transport chain complex II inhibitors, diamide-based ranodine receptor modulators, chord organ modulators, meta-diamide-based GABA-gated chloride channel allosteric modulators, isoxazoline GABA-gated chloride channel allosteric modulators, calcium-activated potassium channel modulators, mitochondrial electron transport chain complex III inhibitors (Qi site), azadirachtin, trifluramide and cypermethrin.

[13] The method of [10] or [11], wherein the insecticide is selected from the group consisting of chloranil, chloranil, chloranil, chloranil, butyl ... , fosai, nefophos, gafosone, marathon, damason, DMTP (destroy pine), parathion, PAP (saidasone), bufeisong, prathiozone, chlordane, anzafen, esp, fipronil, butene flubendiamide, pyraclostrobin, ananine, bifenthrin, cypermethrin, cypermethrin, β-cypermethrin, cyloracetamide Ning, γ-sironine, λ-sironine, sironine, diazolin, β-sironine, θ-sironine, ζ-sironine, σ-sironine, dizolin, fenping, fenpurin, fenhuali, husienning, fluchlorfenthrin, fuhuali, τ-fuhuali, permethrin, silfufen, tafenin, tyromine, trifluthrin, Pyrethrin, tetrafluthrin, methoxythrin, clothianidin, furoate, idarucizumab, nitramexam, segopat, seroquel, seroquel, flupyrimin, flumethasone, diclofenac, flupyrimin, sinostat, sinomethoxazole, abatin, phentermine benzoate, lepidomicil, mitoxantrone Metformin, Ivermectin, Methiocarb, Methiocarb, Mefenoxam, Fenoxac, Peripfen, Paimetrin, Pyrifoquinazole, Afuping, Ethiocarb, Kefencarb, Hecydole, Taifenron, Fenton, Demitomyces, Kefanpai, Flumioxanil, Pedan hydrochloride, Kefron, Diflubenzuron, Diflubenzuron, Flufenuron, Flufenuron , Liufulong, Lufenlong, Novalon, Nofulong, Defulong, Sanfulong, Bufenjing, Miefeno, Kefenno, Hefenlong, Defenno, Triamitron, Aimeson, Subaquinone Mites, Fimfetil, Bifenmite, Bidaben, Fenpromite, Defenrui, Defenrui, Bitaifen, Indeke, Meflunomide, Cipaifen, Cimeifen, Cipaidi , Cipaimie, Saipaifen, Saifenmite, Pyflubumide, Keanbo, Cyclobromide, Saianbo, Fludami, Teanbo, Chloroflucypromid, Tetrachloramide, Sulfocyclamide, Fluniamide, Bromoflubenzamide, Piperfuranilide, Fluoxazolidinone, Isoflualanam, Acynonapyr, Flumetolquine, Benzpyrimoxan, Triflumex, Fentazolam, Sulfiflumin and Flufenamid.

[14] The method of [10] or [11], wherein the insecticide is selected from the group consisting of chloranil, ... Ding, Furoxamide, Idamine, Nipyram, Segope, Sesoan, Synote, Synosarc, Abatin, Inmetin Benzoate, Repimectin, Mimetin, Peripfen, Pyrifoquinazole, Ethiocarb, Taifenlon, Fenta, Dedecarb, Clafamp, Pedan Hydrochloride, Kefron, Difuron, Flufenol, Lufenol, Defuron, Bufenjing, Mefenno, Cofenno, Defenno, Quinone mites, Bifen mites, Bidaben, Fenpromide, Defenrui, Defenrui, Bitaifen, Sipaifen, Simeifen, Saipaifen, Saifen mites, Pyflubumide, Keanbo, Cyclobromofenamide, Saianbo, Fludime, Teanbo, Thiocyclamide, Fluniamide, Bromifenamide, Piperonyl furanamide At least one insecticide selected from the group consisting of piperfuranilide, fluoxazolamide, isoflualanam, acinonapyr, flumetoquine, benzopyrimoxan, trifluoromethylpyrifos, sulfiflumin and fluazifop.

[15] The method of [10] or [11], wherein the insecticide is selected from the group consisting of chloranil, ... Li, benzimidin, tafenin, tylosin, pyrethrin, methacrylic acid, clothianidin, furoate, idarucizumab, nitram, saigope, sasoan, synote, synote, abatin, entrimetin benzoate, lepidomectin, mitrin, belipfen, pyrimethamine, ethidium bromide , tafenlon, cypermethrin, defenamy, clofenpai, pedan hydrochloride, clofenlon, diflufenlon, flufenlon, lufenlon, defenlon, bufenjing, mefenno, kofenno, defenno, quinone mite, bifenmite, bidaben, fenpromite, defenrui, defenrui, bifenmite, sipaifen, sipaifen, sipaifen, sipaifen, sipaifen, pyflubumide, keanbo, cyclobromide, sipaifen, fludime, teanbo, fluniamide, fluoxazolamide, acynonapyr and flumetoquine.

[16] The method of [10] or [11], wherein the insecticide is at least one insecticide selected from the group consisting of bifenthrin, furodiamide, idarucizumab, senostat, senomethoxazole, abatin, pyrifoquinoxaline, clofenton, bufenac, fenpropimorph, defenrexate, cyproconazole, cycloheximide, cyproconazole, flunilide, and fluazifop.

[17] The method of [10] or [11], wherein the mixing ratio of acetic acid glyceryl ester to the insecticide is 1:1000 to 1000:1 by weight. [18] The method of [10] or [11], wherein the mixing ratio of acetic acid glyceryl ester to the insecticide is 80:1 to 3:1 by weight. [19] The method of [10] or [11], wherein the mixing ratio of acetic acid glyceryl ester to the insecticide is 45:1 to 3:1 by weight.

[20] A combination for enhancing the effect of an insecticide on pests that have developed resistance to the insecticide, characterized in that it contains acetic acid glycerol and an insecticide. [21] A mixture for enhancing the effect of an insecticide on pests that have developed resistance to the insecticide, characterized in that it contains acetic acid glycerol and an insecticide as active ingredients. [22] An insecticide composition, which is a composition in which the effect of an insecticide on pests that have developed resistance to the insecticide is enhanced, characterized in that it contains acetic acid glycerol and an insecticide as active ingredients. [Examples]

In order to describe the present invention in more detail, embodiments are described below, but the present invention is not limited to these examples.

Test Example 1 Tea leafhopper control effect test In a tea farm (variety: Lubei), the single-use area of acetic acid glycerol diluted to a predetermined concentration was sprayed three times at intervals of 7 days on mature trees (growing period of dihydrate tea) and was sprayed on stems and leaves using a power spreader (spraying water volume: 3000L/ha). In addition, the area where the pesticide was used alone or the area where the pesticide was mixed with acetic acid glycerol was sprayed only once on the first day of spraying, and was sprayed on stems and leaves using a power spreader. 19 days after treatment, a 25.6cm×18.1cm ceramic clapper was placed in a polyethylene bag (thickness: 0.05mm, width: 230mm, length: 350mm) and a transparent adhesive for catching pests (trade name: Jinlong Spray, manufactured by SDS Biotech) was evenly sprayed on the surface of the polyethylene bag to make an adhesive board. The board was pressed on the tea tree leaf layer, and the tea tree leaf layer was slapped 3 times by hand toward the adhesive board to capture the fallen tea leaf cicadas for investigation (4 locations in each area). Test reagents: ・Acetyl fatty acid glyceride (trade name: Bemidetach, manufactured by Ishihara Sangyo Co., Ltd.) ・Insecticide flunilide (trade name: Ulala DF, manufactured by Ishihara Sangyo Co., Ltd.) ・Insecticide cyclobromofenamide (trade name: Teppan liquid, manufactured by Ishihara Sangyo Co., Ltd.)

The control value is calculated according to the following formula. Control value = (1-Number of captured insects in the treated area/Number of captured insects in the untreated area) × 100 In addition, the theoretical value (E) is calculated according to Colby's formula. (E) = (X + Y) - XY / 100 X = Control value of using acetic acid glyceride alone Y = Control value of using insecticide alone When the control value is higher than the theoretical value, the combination of the present invention has a multiplication effect (unexpected effect). The test results are shown in Table 1.

By adding acetic acid glyceride, the control effect of the insecticide will be greatly improved.

Test Example 2 Test on the control effect of tea leafhopper The test was carried out in the same manner as in Test Example 1 except that the following agents were used as test agents. The survey was carried out 21 days after the treatment. Test agents: ・Acetyl fatty acid glyceride (trade name: Bemidetach, manufactured by Ishihara Sangyo Co., Ltd.) ・Fluniamide (trade name: Ulala DF, manufactured by Ishihara Sangyo Co., Ltd.) ・Cyclobromide (trade name: Teppan liquid; manufactured by Ishihara Sangyo Co., Ltd.) ・Defenazol (trade name: Hachihachi emulsion, manufactured by Nippon Agrochemical Co., Ltd.) ・Pyrifluquinazole (trade name: Colt granular hydrate, manufactured by Nippon Agrochemical Co., Ltd.) ・Bifenin (trade name: Talstar hydrate, manufactured by FMC Corporation)

As a comparison agent for acetic acid glyceride, a combination of fatty acid glyceride (trade name: SunCrystal emulsion, manufactured by Sankei Chemical Co., Ltd.), a mixture of safflower oil and cottonseed oil (trade name: Suffoil emulsion, manufactured by OAT Agrio Co., Ltd.), and wax (trade name: Abion E, manufactured by Abion Co., Ltd.) was also examined. The test results are shown in Tables 2-1 to 2-5.

Numbers in the table: control price, numbers in brackets are theoretical values

Numbers in the table: control price, numbers in brackets are theoretical values

Numbers in the table: control price, numbers in brackets are theoretical values

Numbers in the table: control price, numbers in brackets are theoretical values

Numbers in the table: control price, numbers in brackets are theoretical values

According to the description of non-patent document 2, fluniamide, defenac and pyrifoquinoxaline originally showed extremely high insecticidal effects on tea green leaf cicada. However, in this test, all of them only obtained low insecticidal effects, and it is speculated that resistance to the above-mentioned insecticides has developed. For such tea green leaf cicada, if acetic acid glyceride is used in combination with insecticides, all of them show significant insecticidal effects.

Test Example 3 Test on the control effect of tobacco powder fly Q-type biological subspecies Tomato seedlings (variety: House Momotaro) were grown in black vinyl plastic pots (diameter 75mm) to the 4-leaf stage, and the prescribed amount of liquid was sprayed on the surface and back of the leaves with a handheld sprayer. After the liquid was dried, the pots were placed one by one in a seedling box (60×60×200mm; manufactured by SPL Life Sciences) and 50 tobacco powder fly adults within 2 days of emergence were placed. Four days after the insects were released, the number of tobacco powder flies that settled was investigated. Test agents: acetic acid glyceride (trade name Bemidetach; manufactured by Ishihara Sangyo Co., Ltd.), a mixture of bufendin and fenpropipromide (trade name Applaud Ace Flowable; manufactured by Nippon Agrochemical Co., Ltd.) The control value was calculated according to the following formula. Control value = (1-number of resident insects in the treated area/number of resident insects in the untreated area) × 100

Test Example 4 Test on the control effect of western flower worm Adults of western flower worm were released on eggplant (variety: Qianliang No. 2) from seedlings to the 4-5 leaf stage. When 1-2 year old larvae appeared (5-6 leaf stage of eggplant), the number of parasitic larvae was counted and then a predetermined amount of liquid was sprayed with a handheld sprayer (30 ml/plant). After the liquid was dried, the plants were raised in a greenhouse and the number of adults of western flower worm was counted 14 days after the treatment. Test agents: acetic acid glyceride (trade name Bemidetach; manufactured by Ishihara Sangyo Co., Ltd.), clofolon (trade name Atabron emulsion; manufactured by Ishihara Sangyo Co., Ltd.) The control value was calculated according to the following formula. Control price = (1-number of adults in the treated area/number of adults in the untreated area) × 100

Test Example 5 Test on the control effect of tea leafhopper The test was carried out in the same manner as in Test Example 1 except that the following agent was used as the test agent. The survey was carried out 20 days after the treatment. Test agent: ・Acetyl fatty acid glyceride (trade name: Bemidetach, manufactured by Ishihara Sangyo Co., Ltd.) ・Fluoxathiapiprolin (trade name: Gracia emulsion, manufactured by Nissan Chemical Co., Ltd.)

Test Example 6 Test on the control effect of tea leaf cicada and small yellow horse The test was carried out in the same way as Test Example 1, except that the following drugs were used as test drugs and small yellow horse was investigated at the same time. The investigation was carried out 6 days after the treatment. Test reagents: ・Acetylglycerol (trade name: Bemidetach, manufactured by Ishihara Sangyo Co., Ltd.) ・Abatin (trade name: Agrimec emulsion, manufactured by Syngenta Japan Co., Ltd.) ・Idamine (trade name: Admire hydrating agent, manufactured by Bayer CropScience Co., Ltd.) ・Ciaran (trade name: Exirel SE, manufactured by FMC Corporation) ・Furoxamicarb (trade name: Starkle granular hydrating agent, manufactured by Mitsui Chemicals Co., Ltd.) ・Spinosac (trade name: Spino Ace FL, manufactured by Corteva Co., Ltd.) ・Diana SC (trade name: Diana SC, manufactured by Sumitomo Chemical Co., Ltd.)

Numbers in the table: control price, numbers in brackets are theoretical values

Numbers in the table: control price, numbers in brackets are theoretical values

Test Example 7 Tea moth control effect test In a tea farm (variety: Lubei), for mature trees (growing period of dihydrate tea) in each area where acetic acid glycerol was diluted to a predetermined concentration, where insecticide was used alone, or where insecticide and acetic acid glycerol were mixed, stem and leaf spraying was performed using a hand pressure sprayer (spreading water volume: 3000L/ha). After 12 days of treatment, the number of triangular leaf curlers in the entire treatment area was investigated, and the control value was calculated according to the following formula. Control value = (1-number of triangular leaf rolls in the treated area/number of triangular leaf rolls in the untreated area) × 100 Test agents: ・Acetyl glycerol fatty acid ester (trade name: Bemidetach, manufactured by Ishihara Sangyo Co., Ltd.) ・Fluoxathiapiprolin (trade name: Gracia emulsion, manufactured by Nissan Chemical Co., Ltd.)

Numbers in the table: control price, numbers in brackets are theoretical values

Test Example 8 Tea moth control effect test The test was carried out in the same manner as in Test Example 7 except that the following test agents were used as test agents. The survey was carried out 20 days after the treatment. Test agents: ・Acetyl fatty acid glyceride (trade name: Bemidetach, manufactured by Ishihara Sangyo Co., Ltd.) ・Samcor (trade name: Samcor FL, manufactured by FMC Corporation)

Numbers in the table: control price, numbers in brackets are theoretical values

Test Example 9 Tea Roller Control Effect Test In a tea farm (variety: Lubei), a hand pressure spreader was used to spread the leaves of mature trees (growing period of Sanshui tea) in the areas where acetic acid fatty acid glyceride diluted to a predetermined concentration was used alone, the area where the insecticide was used alone, and the area where the insecticide and acetic acid fatty acid glyceride were mixed (spreading water volume: 3000L/ha). After 20 days of treatment, the leaves of the entire treatment area were collected, and the number of surviving larvae inside was investigated, and the control value was calculated according to the following formula. Control value = (1-number of surviving larvae in the treated area/number of surviving larvae in the untreated area) × 100 Test agents: ・Acetyl glycerol (trade name: Bemidetach, manufactured by Ishihara Sangyo Co., Ltd.) ・Abatin (trade name: Agrimec emulsion, manufactured by Syngenta Japan Co., Ltd.) ・Ceambo (trade name: Exirel SE, manufactured by FMC Corporation) ・Spino Ace (trade name: Spino Ace FL, manufactured by Corteva Corporation)

Figures in the table: control price, the figures in brackets are theoretical values [industrial availability]

According to the composition and method of the present invention, a high insecticidal effect can be obtained for pests that are resistant to insecticides. In addition, the entire contents of the specification, patent application scope and invention abstract of Japanese Patent Application No. 2023-033722 filed on March 6, 2023 are cited here and included as a disclosure of the present invention specification.

Claims (16)

A composition for enhancing insecticidal effect is a composition for enhancing the effect of an insecticide on pests that are resistant to the insecticide, and is characterized in that it contains acetic acid fatty acid glyceride as an active ingredient. The composition for enhancing insecticidal effect of claim 1, wherein the insecticide is selected from the group consisting of carbamate acetylcholine esterase inhibitors, organophosphorus acetylcholine esterase inhibitors, cyclic diene organochlorine GABA-gated chloride channel blockers, phenylpyrazole GABA-gated chloride channel blockers, Channel blockers, pyrethrin-like or pyrethrin-based sodium ion channel modulators, neonicotinoid-based nicotinoid acetylcholine receptor competitive modulators, sulfonimide-based nicotinoid acetylcholine receptor competitive modulators, butenolide-based nicotinoid acetylcholine receptor competitive modulators, mediators Nicotine-type acetylcholine receptor competitive modulators, pyridine subunit-based nicotinic acetylcholine receptor competitive modulators, spinosyn-based nicotinic acetylcholine receptor allosteric modulators (site I), avermectin-based or pulsatile glutamine-gated chloride channel allosteric modulators, juvenile hormone analogs, juvenile hormone-like preparations, pyridine azomethine derivatives chord organ TRPV channel modulators, pyropene-based chord organ TRPV channel modulators, mite growth inhibitors acting on CHS1, mitochondrial ATP synthase inhibitors, proton gradient interference Oxidative phosphorylation uncoupler, sandworm toxin analog nicotinic acetylcholine receptor channel blocker, benzoylurea-based chitin biosynthesis inhibitor acting on CHS1, chitin biosynthesis inhibitor type 1, desquamation inhibitor (Diptera), diacylhydrazine-based desquamation hormone receptor agonist , octopamine receptor agonists, mitochondrial electron transport chain complex III inhibitors (Qo site), mitochondrial electron transport chain complex I inhibitors, oxadiazine-based potential-dependent sodium ion channel blockers, semicarbazine-based potential-dependent sodium ion channel blockers, tetronic acid and tetramic acid At least one insecticide selected from the group consisting of derivative acetyl coenzyme A carboxylase inhibitors, β-keto derivative mitochondrial electron transport chain complex II inhibitors, anilide-based mitochondrial electron transport chain complex II inhibitors, diamide-based ranodine receptor modulators, chord organ modulators, meta-diamide-based GABA-gated chloride ion channel allosteric modulators, isoxazoline GABA-gated chloride ion channel allosteric modulators, calcium-activated potassium ion channel modulators, mitochondrial electron transport chain complex III inhibitors (Qi site), azadirachtin, trifluramide and cypermethrin. The composition for enhancing the insecticidal effect of claim 1 or 2, wherein the insecticide is selected from the group consisting of chloranil, chloranil, chloranil, butyl ... Miesong, Pomiesong, Fusaide, Xinyanfophos, Jiafusong, Marathon, Damason, Miedasong, Balason, Saidazon, Bufeisong, Prothiosone, Chlordane, Anzafan, Yispu, Fipronil, Butenyl Fipronil, Pyraclostrobin, Ananine, Bifennin, Cypermethrin, Cyverin, β-Cyverin, Cyronin, γ-Cyverin Loning, λ-Ceronine, Ceronine, Atreonine, β-Ceronine, θ-Ceronine, ζ-Ceronine, σ-Ceronine, Demide, Efenine, Fenpurin, Fenhuali, Husienning, Flumethrin, Fuhuali, τ-Fuhuali, Permethrin, Sihufen, Taifuning, Tymide, Trifluthrin, Pyrethrin, Flumethrin, methoxythrin, chloranil ... , methoxyfenethyl, methoxyfenpyrazone, mefenopyr, fenoxac, belipfen, penicillin, pyrifos, afuping, edaphate, kefen mites, cypermethrin, tafenron, cypermethrin, demitomyces, clevanpai, flubendiamide, pedan hydrochloride, clofolan, diflubenzuron, diflunisal, flufenuron, flufenuron, hexaflumuron, rosuvastatin Fenlon, Novalon, Nofulon, Defulon, Sanfulon, Bufenjing, Miefno, Kefenno, Hefenlon, Defenno, Triamin, Aimeson, Subaquinone, Fimfetil, Bifenmite, Bidaben, Fenpromite, Defenrui, Defenrui, Bitaifen, Indeke, Meflunomide, Cipafen, Cipafen, Cipaidi, Cipaimie, Saifen At least one insecticide selected from the group consisting of: Pyfen, Cyfenamy, Pyflubumide, Cianbol, Cyclobromide, Cyanbol, Fludime, Teanbol, Chloroflucyranide, Tetrachloranide, Sulfocyclamide, Flunilide, Bromitriptyline, Piperfuranilide, Fluoxazolidinone, Isoflualanam, Acynonapyr, Flumetolquine, Benzpyrimoxan, Flumethoxan, Flufenamid, Sulfiflumin and Flufenamid. The composition for enhancing the insecticidal effect of claim 1 or 2, wherein the insecticide is selected from the group consisting of chloranil, ... Clonidin, furoate, idarucizumab, nitram, segopet, segopet, segopet, abatin, entrimidine benzoate, lepidomectin, mitrimectin, belipfen, pyrifoquinazole, edimethionine, tifron, mitofuron, demitomycin, clofenac, pedan hydrochloride, clofron, difron, flufenuron, rufenuron, defron, bufenjing, fenfenno, kefenac Fenno, Defenno, Quinone mites, Bifen mites, Bidaben, Fenpromide, Defenrui, Defenrui, Bitaifen, Sipaifen, Simeifen, Saipaifen, Saifen mites, Pyflubumide, Keanbo, Cyclobromofenamide, Saianbo, Fludime, Teanbo, Thiocyclamide, Fluniamide, Bromifenamide, Piperonyl furanamide (Pi At least one insecticide selected from the group consisting of perfuranilide, fluoxazolamide, isoflualanam, aceynonapyr, flumetoquine, benzopyrimoxan, trifluralin, fenthiocarbamide, sulfiflumin and flufenacet. The composition for enhancing the insecticidal effect of claim 1 or 2, wherein the insecticide is selected from the group consisting of chloranil, ... , Fuhuali, Baimianning, Taifuning, Taimianning, pyrethrin, amine, clothianidin, furoate, idarucizumab, nitram, segope, seroquel, sinostat, sinokill, abatin, entimin benzoate, lepidomectin, mitrin, belipfen, pyrimethamine, ethidium bromide, At least one insecticide selected from the group consisting of tafenalon, cypermethrin, defenalon, clofenpai, pedan hydrochloride, clofenalon, diflufenalon, flufenalon, lufenalon, defenalon, bufenjing, mefenalon, kefenalon, defenalon, quinone mite, bifenalon, bidaben, fenpromide, defenrui, defenrui, bifenalon, sipaifen, sipaifen, sipaifen, sipaifen, sipaifen, pyflubumide, cyanbo, cyclobromide, cyanbo, fludime, teanbo, fluniamide, fluoxazolamide, aceynonapyr and flumetoquine. A composition for enhancing insecticidal effect as claimed in claim 1 or 2, wherein the insecticide is at least one insecticide selected from the group consisting of bifenthrin, furodiamide, idarucizumab, sinostat, sinostat, abatin, pyrifoquinazole, clofuron, bufenac, fenpropathrin, defenrexate, cyproconazole, cyclobromide, cyproconazole, fluniamide and fluoxetine. A method for using acetic fatty acid glyceride and an insecticide to enhance the insecticidal effect on pests that have developed resistance to the insecticide. A method for controlling insect pests that are resistant to insecticides is characterized by applying acetic acid fatty acid glyceride and an insecticide to the insect pests that are resistant to insecticides, the habitat of the insects, or plants or soil for cultivating plants. The method of claim 7 or 8, wherein the insecticide is selected from the group consisting of carbamate acetylcholine esterase inhibitors, organophosphorus acetylcholine esterase inhibitors, cyclic diene organochlorine GABA-gated chloride channel blockers, phenylpyrazole GABA-gated chloride channel blockers, Pyrethrin-like or pyrethrin-based sodium ion channel modulators, neonicotinoid-based nicotinoid acetylcholine receptor competitive modulators, sulfonimide-based nicotinoid acetylcholine receptor competitive modulators, butenolide-based nicotinoid acetylcholine receptor competitive modulators, mesogenic-based nicotinoid acetylcholine receptor competitive modulators Choline receptor competitive modulators, pyridinyl subunit nicotinic acetylcholine receptor competitive modulators, spinosyn nicotinic acetylcholine receptor allosteric modulators (site I), avermectin or pulsatile glutamine-gated chloride channel allosteric modulators, juvenile hormone analogs, juvenile hormone-like preparations, pyridinium azomethine derivatives chord organ TRPV channel modulators, pyropene chord organ TRPV channel modulators, mite growth inhibitors acting on CHS1, mitochondrial ATP synthase inhibitors, oxidation that interferes with the proton gradient Phosphorylation uncouplers, sandworm toxin analogs nicotinic acid-type acetylcholine receptor channel blockers, benzoylurea-based chitin biosynthesis inhibitors acting on CHS1, chitin biosynthesis inhibitor type 1, exfoliation inhibitors (Diptera), diacylhydrazine-based exfoliation hormone receptor agonists, octopamine receptor agonists, mitochondrial electron transport chain complex III inhibitors (Qo site), mitochondrial electron transport chain complex I inhibitors, oxadiazine-based potential-dependent sodium ion channel blockers, semicarbazine-based potential-dependent sodium ion channel blockers, tetronic acid and tetramic acid derivatives At least one insecticide selected from the group consisting of bioacetyl coenzyme A carboxylase inhibitors, β-keto derivative mitochondrial electron transport chain complex II inhibitors, acylanilide-based mitochondrial electron transport chain complex II inhibitors, diamide-based ranodine receptor modulators, chord organ modulators, meta-diamide-based GABA-gated chloride channel allosteric modulators, isoxazoline GABA-gated chloride channel allosteric modulators, calcium-activated potassium channel modulators, mitochondrial electron transport chain complex III inhibitors (Qi site), azadirachtin, trifluramide and cypermethrin. The method of claim 7 or 8, wherein the insecticide is selected from the group consisting of chloranil, chloranil, chloranil, chloranil, butyl ... , new nicotinoids, gafosone, marathon, damason, DMTP (destroy pine), parathion, PAP (saidasone), bufeisong, prathiozone, chlordane, anthraquinone, isap, fipronil, butene flubendiamide, pyraclostrobin, ananine, bifenthrin, cypermethrin, cypermethrin, β-cypermethrin, cypermethrin, γ- Cerionine, λ-Cerionine, Cerionine, Amidinine, β-Cerionine, θ-Cerionine, ζ-Cerionine, σ-Cerionine, Dimidinine, Efenin, Fenpurin, Fenhuali, Husienine, Flumethrin, Fuhuali, τ-Fuhuali, Permethrin, Sihufen, Taifuning, Tymidin, Trifluthrin, Pyrethrin , tetrafluthrin, methoxythrin, clothianidin, furoate, idarucizumab, nitramexam, segopet, seroquel, seroquel, flupyrimin, flumethopioid, diclofenac, flupyrimin, sinostat, sinomethoxazole, abatin, phentermine benzoate, lepidomicil, mitoxantrone, ivirtuin, sinomethoxazole, ivirtuin, sinomethoxazole, sinomethoxazole, tretinoin ... streptomycin, methoxyfenethyl, methoxyfenopyrin, mefenopyrin, fenoxac, belipfen, penicillin, pyrifoquinazole, afuping, edaphate, kefen mites, hesaduo, tafenron, mites multi, demit, kefanpai, flubendiamide, pedan hydrochloride, kefulong, diflubenzuron, diflunisal, flufenuron, flufenuron, hexaflumuron, Lufenlong, Novalon, Nofulong, Defulong, Sanfulong, Bufenjing, Miefno, Kefenno, Hefenlong, Defenno, Triamin, Aimeson, Subaquinone Mites, Fimfetil, Bifenmite, Bidaben, Fenpromite, Defenrui, Defenrui, Bitaifen, Indeke, Meflunomide, Cipafen, Cipafen, Cipaidi, Cipaime, Saifen At least one insecticide selected from the group consisting of: Pyfen, Cyfenamy, Pyflubumide, Cianbol, Cyclobromide, Cyanbol, Fludime, Teanbol, Chloroflucyranide, Tetrachloranide, Sulfocyclamide, Flunilide, Bromitriptyline, Piperfuranilide, Fluoxazolidinone, Isoflualanam, Acynonapyr, Flumetolquine, Benzpyrimoxan, Flumethoxan, Flufenamid, Sulfiflumin and Flufenamid. The method of claim 7 or 8, wherein the insecticide is selected from the group consisting of chloranil, ... Amine, idarucizumab, nitramepin, segopet, segopan, senostat, senocid, abatin, entrimetin benzoate, lepidomectin, mitrimetin, belipfen, pyrifoquinazole, edamicin, tifron, mitofuron, demitomycin, clofenpai, pedan hydrochloride, clofron, difron, flufenron, lufenron, defron, bufenjing, fenfenno, kefenno, defron Fenno, quinone mites, Bifen mites, Bidaben, Fenpromide, Defenrui, Defenrui, Bitaifen, Sipaifen, Simeifen, Saipaifen, Saifen mites, Pyflubumide, Keanbo, Cyclobromofenamide, Saianbo, Fludime, Teanbo, Thiocyclamide, Fluniamide, Bromoflubenzamide, Piperonylfuranamide (Pipe At least one insecticide selected from the group consisting of rfuranilide, fluoxazolamide, isoflualanam, aceynonapyr, flumetoquine, benzopyrimoxan, trifluralin, fenthiocarbamide, sulfiflumin and flufenicol. The method of claim 7 or 8, wherein the insecticide is selected from the group consisting of chloranil, ... Ning, Taifuning, Tymexing, Pyrethrin, Amidopyr, Clonidin, Furoxamide, Idamine, Nifenam, Saigope, Saisuan, Synote, Synote, Abatin, Inmetin Benzoate, Rapimectin, Mimetin, Belipfen, Pyrifoquinazole, Ethioprine, Taifenlon, At least one insecticide selected from the group consisting of cypermethrin, dimethoate, chlorfenapyr, pyridamole hydrochloride, chlorfenapyr, dimethoate, flufenolone, rufenolone, deflufenolone, bufenjing, mefenol, kofenol, defenol, quinone mite, bifenmite, bidaben, fenpromide, defenrui, defenrui, bitaifen, sipaifen, sipaifen, sipaifen, sipaifen, sipaifen, pyflubumide, cyanbo, cyclobromide, cyanbo, fludime, teanbo, fluniamide, fluoxazolamide, aceynonapyr and flumetoquine. The method of claim 7 or 8, wherein the aforementioned insecticide is at least one insecticide selected from the group consisting of bifenthrin, furodiamide, idarucizumab, senostat, senocid, abatin, pyrifoquinazole, clofuron, bufenac, fenpropathrin, defenrexate, clomiphene, cyclanil, cyfluthrin, fluniamide, and fluoxetine. A combination for enhancing the effect of an insecticide on pests that have developed resistance to the insecticide, characterized by containing acetic acid fatty acid glyceride and an insecticide. A mixture for enhancing the effect of an insecticide on pests resistant to the insecticide, characterized in that it contains acetic acid fatty acid glyceride and the insecticide as active ingredients. An insecticide composition is a composition in which the effect of an insecticide on pests that are resistant to the insecticide is enhanced, and is characterized in that it contains acetic acid fatty acid glyceride and an insecticide as active ingredients.