TW202203911A - Composition for suppressing cellular senescence, and method for suppressing cellular senescence - Google Patents

Abstract

The purpose of the present invention is to provide a composition for suppressing cellular senescence and a method for suppressing cellular senescence, both of which can suppress cellular senescence effectively. The present invention relates to: a composition for suppressing cellular senescence, which contains at least one sesamin compound as an active ingredient: and others.

Description

Composition for inhibiting cell aging and method for inhibiting cell aging

The present invention relates to a composition for inhibiting cell aging. In addition, the present invention relates to methods and the like for inhibiting cell aging.

Cell aging refers to a state in which cell proliferation is irreversibly stopped. For example, in normal somatic cells of mammals such as humans, the number of divisions that can be performed is limited, and if cell division is repeated for a certain number of times, cell division is irreversibly stopped.

Unlike apoptosis, cells that have undergone cellular aging (senescent cells) do not die on their own. Therefore, aging cells accumulate in tissues and organs with increasing age (Non-Patent Document 1). Aging cells not only stop the cell cycle, but also reduce their function as cells. In addition, the physiological activity factors secreted by the aging cells interfere with the surrounding normal cells, resulting in a decrease in the function of the organs, and the like. As a technique for inhibiting cell aging, for example, Patent Document 1 describes a cell aging inhibitor for leaf stem cells containing astaxanthin and tocopheryl nicotinate as active ingredients.

Senescence-associated β-galactosidase (Senescence-associated β-galactosidase) is known as a marker related to cellular aging. galactosidase: SA-β-Gal) and the like. [Prior Art Literature] [Patent Literature]

Patent Document 1: Japanese Patent Laid-Open No. 2019-218377 [Non-patent literature]

Non-Patent Document 1: Herbig U, Ferreira M, Condel L, Carey D, Sedivy JM. Cellular Senescence in Aging Primates. Science. 2006; 311(5765):1257-1257.

[The problem to be solved by the invention]

An object of the present invention is to provide a composition for inhibiting cell aging which can effectively inhibit cell aging. In addition, an object of the present invention is to provide a method for inhibiting cell aging. [Means of Solving Problems]

As a result of diligent studies to solve the above-mentioned problems, the inventors of the present invention found that sesamin has an effect of inhibiting cell aging.

Although not limited to these, the present invention includes the following compositions for inhibiting cell aging, methods for inhibiting cell aging, and the like. [1] A composition for inhibiting cell aging, comprising one or more kinds of sesamin as an active ingredient. [2] The composition according to the above [1], wherein at least one of sesamin is sesamin and/or episesamin. [3] The composition according to the above [1] or [2], which is an oral composition. [4] The composition according to any one of the above [1] to [3], which is a food or drink. [5] The composition according to the above [1] or [2], which is an external preparation for skin. [6] The composition according to the above [5], which is a cosmetic. [7] The composition according to any one of the above [1] to [6], which contains a composition selected from the group consisting of "inhibiting cell aging", "inhibiting aging cells", "preventing cell aging", "promoting aging cells" One or more labels in the group consisting of "not produced" and "inhibits the increase of aging cells". [8] A method for inhibiting cell aging, comprising administering one or more sesamin compounds. [9] Use of one or more sesamin compounds for inhibiting cell aging. [Inventive effect]

According to the present invention, a composition for inhibiting cell aging that can effectively inhibit cell aging can be provided. Furthermore, according to the present invention, a method for inhibiting cell aging can be provided.

The composition for inhibiting cell aging of the present invention (hereinafter, also referred to as the composition of the present invention in some cases) contains one or more kinds of sesamin as an active ingredient. In the present invention, sesamin is a general term for compounds including sesamin and its analogs. Sesamin is one of the main lignan compounds contained in sesame. Examples of the sesamin analogs include, in addition to episesamin, dioxabicyclo[3.3.0]octane derivatives described in Japanese Patent Laid-Open No. 4-9331. As one or more of sesamin compounds, one of these compounds may be used alone, or two or more of them may be used. Specific examples of sesamin include sesamin, episesamin, sesaminol, episesaminol, sesamol, sesamolin, and the like. Constructs or racemates can be used alone or in combination. In the present invention, as one or more kinds of sesamin, sesamin and/or episesamin are preferred, and sesamin and episesamin are more preferred. In the case of using sesamin and episesamin, these ratios are not particularly limited. For example, sesamin: episesamin (weight ratio) is preferably 1:0.1 to 1:9, more preferably 1:0.3 to 1:0. 1:3, the best is 1:0.5～1:2.

The sesamins used in the present invention are not limited at all by their form or production method. For example, in the case of sesamin, sesamin extracted from sesame oil by a known method (for example, the method described in Japanese Patent Laid-Open No. 4-9331) can be used (referred to as a sesamin extract or a purified product). ). Moreover, a commercially available sesame oil (liquid state) can also be used as it is. However, in the case of using sesame oil, the peculiar flavor of sesame oil is sometimes evaluated as being inferior in function, so it is preferable to use a tasteless and odorless sesamin extract (or refined sesamin extract) obtained from sesame oil. thing). In addition, in the case of using sesame oil, since the content of sesamin is low, if a suitable amount of sesamin is to be blended, the volume of the prepared composition to be administered per unit will become too large, so it may occur during ingestion. Bad things happen. In particular, when a preparation is prepared for oral ingestion, the preparation (tablet, capsule, etc.) becomes too large, and ingestion is hindered. Therefore, it is also preferable to use a sesamin extract (or a sesamin refined product) derived from sesame oil from the viewpoint that the intake amount can be reduced. Sesamins can also be obtained by synthesis. As the method, for example, sesamin and episesamin can be synthesized by the method of Beroza et al. (J. Am. Chem. Soc., 78, 1242 (1956)).

Cell aging, as described above, refers to a state in which cell proliferation is stopped. There are many factors involved in individual aging, and the relationship between individual-level aging and cellular aging is not clear. If the primary cultured cells of humans are subcultured, they will reach the limit of division and become senescent cells. Physiologically active factors secreted by aging cells are generally considered to have adverse effects on surrounding normal cells. Aging cells also reduce their function as cells. Inhibition of cell aging is effective in preventing or improving states or diseases caused by cell aging or an increase in aging cells, such as decreased cell function, decreased organ function, and decreased systemic function. By inhibiting cell aging and inhibiting the increase (accumulation) of aging cells in a subject, effects such as maintenance of cell function, maintenance of organ function, and maintenance of systemic function can be expected.

As shown in the examples below, sesamin-based compounds inhibit the increase in the activity of aging-related acid β-galactosidase (SA-β-Gal), which is an indicator of cell aging, and thus have an effect of inhibiting cell aging. Sesamin can be used as an active ingredient for inhibiting cell aging in a subject. Sesamins are contained in natural products or food-drinks, and are compounds that have been eaten. Therefore, from the viewpoint of safety, it is generally considered that sesamin-based ingestion is less problematic, for example, on a daily basis. According to the present invention, a composition for inhibiting cell aging and the like can be provided which contain a highly safe substance as an active ingredient and have an effect of inhibiting cell aging.

The cell aging inhibitory effect in the present invention can be confirmed by known cell aging markers. Examples of phenomena accompanying cell aging include, for example, an increase in SA-β-Gal activity. In one aspect, the composition for inhibiting cell aging of the present invention is preferably one that inhibits the increase in SA-β-Gal activity.

In mammals such as humans, metabolism and the like generally decrease with age, so it is generally assumed that the rate of removal of senescent cells becomes slower with age. It is believed that the cell senescence inhibitory line is particularly effective in inhibiting the increase of senescent cells, for example, in middle-aged and elderly people. The middle-aged and the elderly include the elderly.

By inhibiting cell aging in subjects such as humans, the increase in aging cells in the subject can be inhibited. In one aspect, the composition of the present invention can be used to prevent or improve states or diseases such as cellular dysfunction, organ dysfunction, and systemic dysfunction. In one aspect, the composition of the present invention can be used to prevent or improve the function decline of organs accompanying aging, and the function decline of the whole body accompanying aging by inhibiting cell aging. In the present specification, prevention includes preventing the onset, delaying the onset, reducing the onset rate, reducing the risk of onset, and the like. Improving a state or disease includes recovering from the state or disease, alleviating the symptoms of the state or disease, improving the symptoms of the state or disease, delaying the progress of the state or disease, preventing it, etc.

The composition for inhibiting cell aging of the present invention can be applied to either therapeutic use (medical use) or non-therapeutic use (non-medical use). The so-called non-therapeutic does not include the medical practice, ie, the concept of human surgery, treatment or diagnosis. The composition for inhibiting cell aging of the present invention can be prepared in the form of, for example, food and beverages, cosmetics, pharmaceuticals, quasi-drugs, and feeds. The composition of the present invention may itself be a food or drink, a cosmetic, a pharmaceutical, a quasi-drug, a feed, or the like for inhibiting cell aging, or may be a material, a preparation, or the like that is blended into these and used. The composition for inhibiting cell aging of the present invention can be provided in the form of a drug as an example, but is not limited to this form. The agent can also be provided as a composition as it is, or in the form of a composition containing the agent. In one aspect, the composition of the present invention may also be referred to as a cell aging inhibitor.

The composition for inhibiting cell aging of the present invention may be either an oral composition or a parenteral composition. In one aspect, the composition of the present invention is preferably an oral composition. Examples of the oral composition include food and beverages, oral pharmaceuticals, quasi-drugs, and feeds, preferably food and beverages or oral pharmaceuticals, and more preferably food and beverages. In another aspect, the composition for inhibiting cell aging can be used as an external preparation for skin (external skin composition). The external preparation for skin includes cosmetics, pharmaceuticals, quasi-drugs, and the like, and is preferably a cosmetic. In one aspect, when the composition of the present invention is used for inhibiting cell aging of the skin, the composition is preferably made into a skin external preparation, more preferably a cosmetic.

The composition for inhibiting cell aging of the present invention may contain optional additives and optional components in addition to one or more of sesamin, provided that the effects of the present invention are not impaired. These additives and components can be selected according to the form of the composition and the like, and those that can be generally used in food and drink, cosmetics, pharmaceuticals, quasi-drugs, feeds, and the like can be used. When the composition of the present invention is used as food and drink, cosmetics, pharmaceuticals, quasi-drugs, feed, etc., the production method is not particularly limited, and it can be produced by a general method.

For example, when the composition for inhibiting cell aging of the present invention is made into food and drink, ingredients that can be used in food and drink (for example, food materials, optional food additives, etc.) can be blended with sesamin. One or more of them can be made into a variety of food and drink products. The food and drink is not particularly limited, and examples thereof include general food and drink, health food, health drink, functionally labeled food, food for specified health use, health supplement, and food and drink for patients. The above-mentioned health food, functionally labeled food, food for specific health use, health supplementary food, etc. can be made into, for example, fine granules, lozenges, granules, powders, capsules, chewable lozenges, dry syrups, syrups, and liquids , beverages, beverages, liquid food and other preparation forms are used.

When the composition for inhibiting cell aging of the present invention is used as a cosmetic, ingredients that can be used in the cosmetic (for example, a carrier and additives acceptable in the cosmetic) can be blended into one of sesamin. A variety of cosmetics can be made from more than one species. The product form of the cosmetics is not particularly limited, and examples thereof include skin care cosmetics such as lotions, cosmetic liquids, facial masks, lotions, creams, and sunscreens.

When the composition for inhibiting cell aging of the present invention is used as a pharmaceutical or a quasi-drug, for example, a pharmacologically acceptable carrier, an additive to be added if necessary, etc. can be blended into one of sesamin. There are more than one kind of medicines or quasi-drugs made into various dosage forms. Such carriers, additives, and the like may be pharmacologically acceptable as long as they can be used in pharmaceuticals or quasi-drugs, and examples thereof include excipients, binders, disintegrating agents, lubricants, antioxidants, colorants 1 or 2 or more of the agents, etc. Oral or parenteral (percutaneous, transmucosal, enteral, injection, etc.) administration forms are mentioned as an administration (ingestion) form of a pharmaceutical or a quasi-drug. In one aspect, when the composition of the present invention is prepared as a pharmaceutical or quasi-drug, it is preferably prepared as an oral pharmaceutical or quasi-drug. Examples of dosage forms for oral administration include liquids, troches, powders, fine granules, granules, dragees, capsules, suspensions, emulsions, and chewable lozenges. In another aspect, the pharmaceutical or quasi-drug is preferably prepared as an external preparation for skin. The dosage form and the like of the external preparation for skin are not particularly limited, and may be in any form such as solution, emulsion, cream, gel, powder, aerosol, spray, capsule, and sheet. The medicinal product may also be a medicinal product for non-human animals.

When the composition for inhibiting cell aging of the present invention is used as a feed, one or more kinds of sesamin compounds may be blended into the feed. Feed additives are also included in the feed. Examples of the feed include livestock feeds for cattle, pigs, chickens, sheep, horses, etc.; small animal feeds for rabbits, rats, mice, etc.; pet foods for dogs, cats, birds, etc. .

The content of sesamin contained in the composition for inhibiting cell aging of the present invention is not particularly limited, and can be set according to the form and the like. The total content of sesamin in the composition of the present invention is, for example, preferably 0.001% by weight or more, more preferably 0.01% by weight or more, still more preferably 0.05% by weight or more, and more preferably 10% by weight or more. % by weight or less, more preferably 5% by weight or less. In one aspect, the total content of sesamin in the composition of the present invention is preferably 0.001 to 10% by weight, more preferably 0.01 to 5% by weight, still more preferably 0.05 to 5% by weight. In the case where the above-mentioned total content contains two or more sesamin-based compounds, it is the total content of these.

The composition for inhibiting cell aging of the present invention can be ingested or administered by various methods known per se, depending on the form or dosage form. In one aspect, the compositions of the present invention are preferably orally ingested (orally administered). In another aspect, when the composition of the present invention is made into an external preparation for skin, it can be applied to the skin. The dosage (also referred to as the intake amount) of the composition for inhibiting cell aging of the present invention is not particularly limited. The dosage of the composition for inhibiting cell aging of the present invention may be an amount that can obtain the effect of inhibiting cell aging, and may be appropriately set according to the form of administration, the method of administration, the body weight of the subject, and the like.

In one aspect, when a human (adult) is ingested or administered the composition for inhibiting cell aging of the present invention, the total dose of sesamin is based on a body weight of 60 kg per day, It is preferably 0.5 mg or more, more preferably 1 mg or more, still more preferably 3 mg or more, and more preferably 200 mg or less, more preferably 100 mg or less, and even more preferably 80 mg or less. In one aspect, if the total dose of sesamin is a human (adult), it is based on a body weight of 60 kg per day, preferably 0.5-200 mg, more preferably 1-100 mg, still more preferably 3-80 mg . It is preferable to ingest or administer the above-mentioned amount once a day or more, for example, once a day or divided into several times (for example, 2 to 3 times). In one aspect, the above-mentioned amounts of sesamin are preferably ingested or administered to humans orally. In one aspect, it is preferable to make human (adult) orally ingest or be administered sesamin and/or episesamin, and in terms of the total dose of sesamin and episesamin administered, every 1 day Based on a body weight of 60 kg, it is preferably 0.5 to 200 mg, more preferably 1 to 100 mg, and even more preferably 3 to 80 mg. In one aspect, the composition for inhibiting cell aging of the present invention can be used for ingesting or administering sesamin in the above-mentioned amount per 60 kg of body weight in humans. In the case where two or more sesamin-based compounds are used, the above-mentioned total dosage is the total amount of these.

The composition for inhibiting cell aging of the present invention is preferably continuously ingested or administered. It is expected that a higher cell aging inhibitory effect can be obtained by continuous ingestion or administration of sesamin. In one aspect, the composition for inhibiting cell aging of the present invention is preferably continuously ingested or administered for 1 week or more, more preferably 4 weeks or more, still more preferably 8 weeks or more, particularly preferably 12 weeks above.

The subject to which the composition for inhibiting cell aging of the present invention is ingested or administered (also referred to as the subject of administration) is not particularly limited. Preferably it is a human or non-human mammal, more preferably a human. In one aspect, as the administration target, there is a need or a desire to suppress cell aging, and the like. As such a target, a middle-aged and elderly person etc. are mentioned, for example. In one aspect, the composition of the present invention is suitably used as a composition for inhibiting cell aging for middle-aged and elderly people. A middle-aged person can be, for example, a human over the age of 40. In one aspect, among middle-aged and elderly persons, the object is preferably an elderly person. An elderly person may be, for example, a human over 60 years old or over 65 years old. The subject of administration can be a healthy person. For example, the composition of the present invention may be used in healthy people for the purpose of preventing or improving a state or disease that can be expected to be prevented or improved by inhibiting cell aging.

The type of cells to be targeted for cell aging suppression is not particularly limited, and examples include fibroblasts, epithelial cells, epidermal cells, basal cells, stem cells, adipocytes, nerve cells, muscle cells, skeletal muscle cells, smooth muscle cells, and muscle fibers. Blast cells, muscle satellite cells, satellite cells, osteoblasts, hepatocytes, hepatic stellate cells, kidney cells, interstitial cells, blood cells, immune cells, endothelial cells, vascular endothelial cells, outer coat cells, crystal cells, retinal cells, etc. In one aspect, the composition for inhibiting cellular aging of the present invention is suitably used for inhibiting cellular aging of fibroblasts. Fibroblasts are cells required for tissue support and structure formation in almost all organs.

The composition for inhibiting cell aging of the present invention may contain, for example, a composition selected from the group consisting of "inhibition of cell aging", "inhibition of aging cells", "prevention of cell aging", "prevention of aging cells" and "reduction of aging cells". The indication of one or more functions of the group consisting of "aging cells", etc. In one aspect of the present invention, the composition of the present invention is preferably a food and drink product or an external preparation for skin with the above-mentioned label, more preferably a food and drink product or a cosmetic, still more preferably a food and drink product. In addition, the above-mentioned indication may also be an indication for obtaining the purpose of the above-mentioned function. The above label can be attached to the composition itself, or to the container or package of the composition.

The present invention also includes the following methods. A method for inhibiting cell aging, comprising administering at least one of sesamin. By administering one or more kinds of sesamin to a subject, cell aging can be suppressed in the subject. The above methods can be therapeutic methods or non-therapeutic methods.

The present invention also includes the following uses. The use of one or more kinds of sesamin, which is used for inhibiting cell aging. One or more kinds of sesamin can be used to inhibit cell aging. The above-mentioned use may be therapeutic or non-therapeutic.

In the above-mentioned method and use, the sesamin and its preferred aspects are the same as the above-mentioned composition for inhibiting cell aging of the present invention. As one or more kinds of sesamin-based compounds, one kind of sesamin-based compound may be used, or two or more kinds thereof may be used. In the above-mentioned method and use, it is preferable that one or more kinds of sesamin are administered (to be ingested) to the subject once or more once a day, for example, once to several times (for example, 2 to 3 times) a day. In one aspect, in the above-mentioned method and use, sesamin is preferably administered orally (ingested). In another aspect, for example, when sesamin is used to inhibit cell aging of the skin, it is preferable to apply one or more kinds of sesamin to the skin. The above use is preferably in humans or non-human mammals, more preferably in humans.

In the above-mentioned method and use, one or more kinds of sesamin can be used in an amount (also referred to as an effective amount) to obtain the desired action. The preferable dose of sesamin, the target of administration, etc. are the same as those of the composition for inhibiting cell aging of the present invention described above. Sesamins may be administered as they are, or may be administered in a form containing these compositions. For example, the above-mentioned composition for inhibiting cell aging of the present invention can also be used. In one aspect, one or more kinds of sesamin can be used to prevent or improve states or diseases such as cellular dysfunction, organ dysfunction, and systemic dysfunction. In one aspect, one or more kinds of sesamin can be used to prevent or improve the function decline of organs accompanying aging, the function decline of the whole body accompanying aging, and the like by inhibiting cell aging.

The present invention also includes the use of one or more kinds of sesamin, which are used to manufacture a composition for inhibiting cell aging. The composition for inhibiting cell aging, its preferable aspects, and the like are the same as those described above. [Example]

Hereinafter, the present invention will be described more specifically based on examples. In addition, this invention is not limited to these Examples.

<Example 1> (preparation of test substance) Sesamin (a mixture of sesamin and episesamin prepared so that the ratio (weight ratio) of sesamin: episesamin was 1:1, purity 98%) was used as a test substance. Sesamin was dissolved in dimethyl sulfoxide (DMSO) at 10 mM, and the final concentration of sesamin was 0.1, 0.3, 1, 3, or 10 μM in culture medium (supplemented with 10% fetal bovine serum (10% fetal bovine serum). FBS) and 1% Penicillin-Streptomycin mixed solution in Dulbecco's modified Eagle's medium (DMEM)) were diluted to prepare a medium containing the test substance. A medium obtained by dissolving only DMSO was used as an unsupplemented medium.

(Cell culture) Normal human fibroblasts (Thermo Fishsher Scientific, C0135C) were seeded in 96 wells at 10,000 cells/0.1 mL/well using a medium (DMEM supplemented with 10% FBS and 1% Penicillin-Streptomycin mixed solution). In a black dish, the culture was performed in a CO ₂ incubator (37° C., 5% CO ₂ , the same below). After 24 hours, the medium was replaced with a medium containing the test substance (sesamin concentration: 0.1, 0.3, 1, 3 or 10 μM) or a medium without supplementation (0.1 mL), and cultured in a CO ₂ incubator for 24 hours. Hour. Next, it was replaced with DMEM supplemented with 100 μM H ₂ O ₂ (hydrogen peroxide) or DMEM without H ₂ O ₂ , and treated with H ₂ O ₂ for 1 hour in a CO ₂ incubator to induce cell aging. In order to avoid the result caused by the direct antioxidant effect, the medium containing H ₂ O ₂ was washed with phosphate buffered saline (PBS), and then replaced with the medium containing the test substance or the medium without supplement (0.1 mL) , cells were cultured for 3 days in a CO ₂ incubator for analysis. The medium containing the test substance or the medium without supplementation was used with the same concentration of the test substance before and after H ₂ O ₂ treatment. For example, cells cultured in a medium containing 0.1 μM sesamin before H ₂ O ₂ treatment were also subjected to a medium containing a test substance containing 0.1 μM sesamin after H ₂ O ₂ treatment. nourish. _The cells cultured in the medium without addition of the test substance before the _H2O2 treatment _were also cultured in the medium without addition of the test substance after the _H2O2 treatment.

(Measurement of SA-β-Gal Activity) The activity of SA-β-Gal, which is a marker of cell aging, was measured. First, the number of cells was measured using the Cell Count Normalization Kit (Tongjin Institute of Chemistry, Inc.). 100 μL of working solution (prepared by 500-fold dilution of the Staining solution with Quenching Buffer) was added to each well, incubated in a CO ₂ incubator for 30 minutes to perform nuclear staining, and the fluorescence intensity ( cell count RFU) was measured (Ex: 350 nm, Em: 461 nm). Next, each well was washed with PBS, and then SA-β-Gal activity was measured using Cellular Senescence Plate Assay Kit (Dojin Chemical Research Institute Co., Ltd.). 50 μL of Lysis Buffer was added to each well, and the cells were lysed by incubation at room temperature for 10 minutes. Next, 50 μL of SPiDER-βGal working solution was added to each well, and after incubation at 37° C. for 30 minutes, the fluorescence intensity (SA-β-Gal RFU) was measured with a fluorescent disc reader (Ex: 535 nm, Em: 580nm). The SA-β-Gal activity was calculated by correcting the fluorescence value of SPiDER-βGal with the fluorescence value of nuclear staining. Significant difference tests _were performed by Student's t _- test (vs without H2O2 treatment) or _Dunnet 's test (vs with _H2O2 treatment without addition of test substance). The results are shown in FIG. 1 .

(Results) Fig. 1 shows SA-β-Gal of normal human fibroblasts treated with hydrogen peroxide and cultured in a medium supplemented with a test substance (sesamin) or a medium without supplementation Activity chart. The results shown in Figure 1 are mean ± standard error (N=3). In Figure 1, # and * indicate significant differences (#p < 0.05, Student's t-test (vs without H ₂ O ₂ treatment), *p < 0.05, Dunnet's test (vs with H ₂ O ₂ treatment, without Add the test substance)). The vertical axis (SA-β-Gal RFU/cell count RFU) represents SA-β-Gal activity per cell. No addition means cells obtained by culturing in a medium without addition of the test substance. SA-β-Gal activity was significantly increased by H ₂ O ₂ treatment. Sesaminoids significantly inhibit the increase in SA-β-Gal activity. From these results, it was shown that sesamin and episesamin have an effect of inhibiting cell aging.

[Fig. 1] Fig. 1 is a graph showing SA-β-Gal activity of normal human fibroblasts treated with hydrogen peroxide and cultured in a medium supplemented with sesamin or a medium without supplementation.

Claims (9)

A composition for inhibiting cell aging, which contains one or more kinds of sesamin as an active ingredient. The composition according to claim 1, wherein at least one of sesamin is sesamin and/or episesamin. The composition of claim 1 or 2 is an oral composition. The composition according to any one of claims 1 to 3, which is food and drink. The composition of claim 1 or 2 is an external preparation for skin. The composition of claim 5 is a cosmetic. The composition according to any one of claims 1 to 6, which contains a composition selected from the group consisting of "inhibiting cell aging", "inhibiting aging cells", "preventing cell aging", "preventing aging cells from being produced" and "inhibiting aging cells" One or more markers in the group consisting of "increase in aging cells". A method for inhibiting cell aging, comprising administering at least one of sesamin. The use of one or more kinds of sesamin, which is used for inhibiting cell aging.

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