TW202128612A - Novel agrochemical composition comprising 4-substituted phenylamidine compounds - Google Patents
Novel agrochemical composition comprising 4-substituted phenylamidine compounds Download PDFInfo
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Abstract
Description
本發明涉及新型農用化學組合物。更具體地，本發明涉及一種包含一種或多種式（I）的苯基脒化合物（作為成分（1））和一種或多種殺真菌活性化合物（作為成分（2））的混合物的新型農用化學組合物。本發明進一步涉及控制植物致病真菌的方法、本發明的新型農用化學組合物在處理一種或多種種子中的用途、保護一種或多種種子的方法以及相應的處理的種子。The present invention relates to a new agrochemical composition. More specifically, the present invention relates to a novel agrochemical combination comprising a mixture of one or more phenylamidine compounds of formula (I) (as ingredient (1)) and one or more fungicidally active compounds (as ingredient (2)) Things. The present invention further relates to a method for controlling phytopathogenic fungi, the use of the novel agrochemical composition of the present invention in the treatment of one or more seeds, a method for protecting one or more seeds, and the corresponding treated seeds.
下面的現有技術文獻報導了使用苯基脒化合物作為殺真菌劑的用途：WO2000046184、WO2003093224、WO2017102635、WO2018069841、WO2018108998和WO2018091430公開了芳基脒衍生物作為殺真菌劑。The following prior art documents report the use of phenyl amidine compounds as fungicides: WO2000046184, WO2003093224, WO2017102635, WO2018069841, WO2018108998 and WO2018091430 disclose aryl amidine derivatives as fungicides.
WO2018228896、WO2015121802、WO2007031507、WO2005089547和WO2003024219公開了包含至少一種芳基脒衍生物和另外一種選自已知殺真菌劑的殺真菌劑混合物。WO2018228896, WO2015121802, WO2007031507, WO2005089547 and WO2003024219 disclose mixtures of fungicides comprising at least one aryl amidine derivative and another selected from known fungicides.
殺真菌劑組合物通常用於促進疾病控制和延緩耐藥性的發展。人們一直希望通過使用能對植物病原體提供治療性、系統性和預防性控制的有效成分混合物來提高活性譜和疾病控制的功效，希望有能提供更大的殘留功效以延長噴淋間隔的組合，還希望能與抑制真菌病原體中不同生化途徑的殺菌劑進行組合，以延緩對任何一種特定植物病害防治劑的抗性的發展。Fungicide compositions are commonly used to promote disease control and delay the development of drug resistance. People have always hoped to improve the activity spectrum and the efficacy of disease control by using a mixture of active ingredients that can provide therapeutic, systemic and preventive control of plant pathogens. It is hoped that there will be a combination that can provide greater residual efficacy to extend the spray interval. It is also hoped that it can be combined with fungicides that inhibit different biochemical pathways in fungal pathogens to delay the development of resistance to any specific plant disease control agent.
人們一直希望殺菌劑能夠有效地控制植物病原體、減少環境中化學製劑的釋放量、具有光譜的殺真菌活性、降低毒性和施用率。本發明將提供至少在某些方面達到所述目的的農用化學組合物。People have always hoped that fungicides can effectively control plant pathogens, reduce the release of chemical agents in the environment, have spectral fungicidal activity, and reduce toxicity and application rates. The present invention will provide an agrochemical composition that achieves the stated objectives in at least some aspects.
令人驚訝的是，已經發現本發明的新型農用化學組合物不僅額外增強要控制的植物病原菌作用譜（原則上這是意料之中的），而且還實現了協同效應。本發明的農用化學組合物的協同效應有助於在維持功效的同時降低成分(1)和成分(2)的施用量，即使在如此低的施用量下這兩種單獨的化合物沒有效果。此外，它還可以在大大拓寬植物病原菌的範圍的同時，提高使用的安全性。Surprisingly, it has been found that the novel agrochemical composition of the present invention not only additionally enhances the action spectrum of the plant pathogens to be controlled (which is expected in principle), but also achieves a synergistic effect. The synergistic effect of the agrochemical composition of the present invention helps to reduce the application amount of the ingredient (1) and the ingredient (2) while maintaining the efficacy, even if the two separate compounds have no effect at such a low application amount. In addition, it can greatly broaden the range of plant pathogenic bacteria while improving the safety of use.
令人驚訝地是，除了殺菌和/或殺線蟲和/或殺蟲性協同活性外，根據本發明的農用化學組合物具有其他特性，在更廣泛的意義上，這些也可以稱為協同作用，例如：將活性譜擴大到其他昆蟲、線蟲和/或植物病原菌，例如，對植物病害的抗性菌株；降低活性化合物的施用率；即使在個別化合物幾乎沒有活性的情況下，在本發明農藥組合物的説明下，也能充分地控制害蟲；在配方或使用過程中（例如，在研磨、篩分、乳化、溶解或配藥過程中）的有利性能；提高了儲存穩定性和光穩定性；在形成殘留物方面較有利；改善了毒理學或生態生物學行為；改善了所謂的植物生理效應的性質，例如生長更好、收穫產量增加、根系更發達、葉面積更大、葉片更綠、嫩枝更結實、所需種子更少、植物毒性更低、能調動植物的防禦系統、具有良好的植物親和性。Surprisingly, in addition to the synergistic activity of bactericidal and/or nematicidal and/or insecticidal properties, the agrochemical composition according to the invention has other properties, which in a broader sense can also be referred to as synergistic effects, For example: expand the activity spectrum to other insects, nematodes and/or plant pathogens, for example, resistant strains to plant diseases; reduce the application rate of active compounds; even when individual compounds have little activity, the pesticide combination of the present invention Under the description of the substance, it can also fully control the pests; in the formulation or use process (for example, in the process of grinding, sieving, emulsifying, dissolving or dispensing); improving storage stability and light stability; More favorable in terms of residues; improved toxicology or eco-biological behavior; improved the properties of so-called plant physiological effects, such as better growth, increased harvest yield, more developed root systems, larger leaf area, greener leaves, and tender The branches are more sturdy, require fewer seeds, have lower phytotoxicity, can mobilize the plant's defense system, and have good plant compatibility.
因此，使用本發明的新型農用化學組合物大大有助於保持穀類幼枝的健康，這增加了例如處理過的穀類種子的冬季存活率，並且還保障了品質和產量。Therefore, the use of the novel agrochemical composition of the present invention greatly contributes to maintaining the health of cereal young shoots, which increases the winter survival rate of, for example, treated cereal seeds, and also guarantees quality and yield.
而且，本發明的新型農用化學組合物有助於增強內吸作用。即使組合中的各個化合物不具有足夠的內吸性，本發明的新型農用化學組合物仍可以具有該性能。類似地，本發明的新型農用化學組合物可以導致更高、更持久殺真菌和/或殺蟲和/或殺線蟲效果。Moreover, the novel agrochemical composition of the present invention helps to enhance the systemic effect. Even if each compound in the combination does not have sufficient systemic properties, the novel agrochemical composition of the present invention can still have this property. Similarly, the novel agrochemical composition of the present invention can lead to higher and longer lasting fungicidal and/or insecticidal and/or nematicidal effects.
因此，本發明提供了一種新型農用化學組合物，其包含：
(1)至少一種式（I）化合物
在一個實施方案中，本發明提供了一種用於控制有害微生物如有害真菌和細菌的方法，該方法包括將至少一種根據本發明的新型農用化學組合物施用於微生物和/或其生境（植物、植物部位、種子、果實或植物生長的土壤）。In one embodiment, the present invention provides a method for controlling harmful microorganisms such as harmful fungi and bacteria, the method comprising applying at least one novel agrochemical composition according to the present invention to the microorganisms and/or their habitats (plants, Plant parts, seeds, fruits, or the soil where the plant grows).
本發明詳細描述：Detailed description of the invention: 定義：definition:
在上述公式中給出的符號的定義中，使用了通常代表以下取代基的集體名詞：In the definition of the symbols given in the above formula, collective nouns that usually represent the following substituents are used:
氫：優選地，氫的定義還包括氫的同位素，優選重氫和超重氫，更優選重氫。Hydrogen: Preferably, the definition of hydrogen also includes isotopes of hydrogen, preferably heavy hydrogen and super heavy hydrogen, more preferably heavy hydrogen.
鹵素:（也可以是在鹵代烷基、鹵代烷氧基等組合中）氟、氯、溴和碘，優選氟、氯、溴，更優選氟、氯；Halogen: (also in a combination of halogenated alkyl, halogenated alkoxy, etc.) fluorine, chlorine, bromine and iodine, preferably fluorine, chlorine, bromine, more preferably fluorine, chlorine;
烷基：（包括在組合中的烷基，如烷硫基、烷氧基等）具有1至6個碳原子的飽和、直鏈或支鏈的烴基自由基，例如C1 -C6 -烷基，如甲基、乙基、丙基、1-甲基乙基、丁基、1-甲基丙基、2-甲基丙基、1,1-二甲基乙基、戊基、1-甲基丁基、2-甲基丁基、3-甲基丁基、2,2-二甲基丙基、1-乙基丙基、己基、1,1-二甲基丙基、1,2-二甲基丙基、1-甲基戊基、2-甲基戊基、3-甲基戊基、4-甲基戊基、1,1-二甲基丁基、1,2-二甲基丁基、1,3-二甲基丁基、2,2-二甲基丁基、2,3-二甲基丁基、3,3-二甲基丁基、1-乙基丁基、2-乙基丁基、1,1,2-三甲基丙基、1,2,2-三甲基丙基、l-乙基-1-甲基丙基、l乙基-2-甲基丙基、庚基和辛基。如果烷基在複合取代基的末端，例如在烷基環烷基中，則複合取代基的起始部分，例如環烷基，可以被烷基在相同或不同的地方獨立地被單或多取代。Alkyl: (including alkyl groups in the combination, such as alkylthio, alkoxy, etc.) saturated, linear or branched hydrocarbyl radicals with 1 to 6 carbon atoms, such as C 1 -C 6 -alkanes Groups, such as methyl, ethyl, propyl, 1-methylethyl, butyl, 1-methylpropyl, 2-methylpropyl, 1,1-dimethylethyl, pentyl, 1 -Methylbutyl, 2-methylbutyl, 3-methylbutyl, 2,2-dimethylpropyl, 1-ethylpropyl, hexyl, 1,1-dimethylpropyl, 1 ,2-Dimethylpropyl, 1-methylpentyl, 2-methylpentyl, 3-methylpentyl, 4-methylpentyl, 1,1-dimethylbutyl, 1,2 -Dimethylbutyl, 1,3-dimethylbutyl, 2,2-dimethylbutyl, 2,3-dimethylbutyl, 3,3-dimethylbutyl, 1-ethyl Butyl, 2-ethylbutyl, 1,1,2-trimethylpropyl, 1,2,2-trimethylpropyl, 1-ethyl-1-methylpropyl, 1-ethyl -2-Methylpropyl, heptyl and octyl. If the alkyl group is at the end of a composite substituent, such as in an alkylcycloalkyl group, the starting part of the composite substituent, such as a cycloalkyl group, may be independently mono- or multiple-substituted by the alkyl group at the same or different places.
鹵代烷基：（包括在組合中的鹵代烷基，例如鹵代烷硫基、鹵代烷氧基等）具有1-6個碳原子的直鏈或支鏈烷基（如上所述，其中這些基團中的一些或全部氫原子可以被上述指定的鹵素原子取代），例子有C1 -C3 -鹵代烷基，如氯甲基、溴甲基、二氯甲基、三氯甲基、氟甲基、二氟甲基、三氟甲基、氯氟甲基、二氯氟甲基、氯二氟甲基、1-氯乙基、1-溴乙基、1-氟乙基、2-氟乙基、2,2-二氟乙基、2,2,2-三氟乙基、2-氯-2-氟乙基、2-氯-2-二氟乙基、2,2-二氯-2-氟乙基、2,2,2-三氯乙基、五氟乙基和1,1,l三氟丙基-2-基。Haloalkyl: (including haloalkyl in the combination, such as haloalkylthio, haloalkoxy, etc.) a straight or branched chain alkyl group having 1 to 6 carbon atoms (as described above, some of these groups or All hydrogen atoms can be replaced by the halogen atoms specified above), examples are C 1 -C 3 -haloalkyl, such as chloromethyl, bromomethyl, dichloromethyl, trichloromethyl, fluoromethyl, difluoromethyl Group, trifluoromethyl, chlorofluoromethyl, dichlorofluoromethyl, chlorodifluoromethyl, 1-chloroethyl, 1-bromoethyl, 1-fluoroethyl, 2-fluoroethyl, 2, 2-Difluoroethyl, 2,2,2-trifluoroethyl, 2-chloro-2-fluoroethyl, 2-chloro-2-difluoroethyl, 2,2-dichloro-2-fluoroethyl Group, 2,2,2-trichloroethyl, pentafluoroethyl and 1,1,ltrifluoropropyl-2-yl.
鹵代甲基：甲基，其中這些基團中的部分或全部氫原子可被上述鹵原子取代，例子有（但不限於）氯甲基、溴甲基、二氯甲基、三氯甲基、氟甲基、二氟甲基、三氟甲基、氯氟甲基、二氯氟甲基、氯二氟甲基，優選三氟甲基。Halomethyl: methyl, in which some or all of the hydrogen atoms in these groups can be replaced by the above halogen atoms, examples include (but not limited to) chloromethyl, bromomethyl, dichloromethyl, trichloromethyl , Fluoromethyl, difluoromethyl, trifluoromethyl, chlorofluoromethyl, dichlorofluoromethyl, chlorodifluoromethyl, preferably trifluoromethyl.
術語“環烷基”是指閉合形成環的烷基。非限制性實例包括但不限於環丙基、環丁基、環戊基和環己基。除非在別處明確限定，否則該定義也適用於作為複合取代基的一部分的環烷基，例如環烷基烷基等。The term "cycloalkyl" refers to an alkyl group that is closed to form a ring. Non-limiting examples include, but are not limited to, cyclopropyl, cyclobutyl, cyclopentyl, and cyclohexyl. Unless specifically defined elsewhere, this definition also applies to cycloalkyl groups that are part of a composite substituent, such as cycloalkylalkyl groups and the like.
“烷氧基”一詞單獨使用或以複合詞的形式使用，包括C1 -C6 烷氧基。烷氧基的實例包括甲氧基、乙氧基、丙氧基、1-甲基乙氧基、丁氧基、1-甲基丙氧基、2-甲基丙氧基、1,1-二甲基乙氧基、戊氧基、1-甲基丁氧基、2-甲基丁氧基、3-甲基丁氧基、2,2-二甲基丙氧基、1-乙基丙氧基、己氧基、1,1-二甲基丙氧基、1,2-二甲基丙氧基、1-甲基戊氧基、2-甲基戊氧基、3-甲基戊氧基、4-甲基戊氧基、1,1-二甲基丁氧基、1,2-二甲基丁氧基、1,3-二甲基丁氧基、2,2-二甲基丁氧基、2,3-二甲基丁氧基、3,3-二甲基丁氧基、1-乙基丁氧基、2-乙基丁氧基、1,1,2-三甲基丙氧基、1,2,2-三甲基丙氧基、1-乙基-1-甲基丙氧基和1-乙基-2-甲基丙氧基和不同的異構體。The term "alkoxy" is used alone or as a compound word, including C 1 -C 6 alkoxy. Examples of alkoxy groups include methoxy, ethoxy, propoxy, 1-methylethoxy, butoxy, 1-methylpropoxy, 2-methylpropoxy, 1,1- Dimethylethoxy, pentoxy, 1-methylbutoxy, 2-methylbutoxy, 3-methylbutoxy, 2,2-dimethylpropoxy, 1-ethyl Propoxy, hexyloxy, 1,1-dimethylpropoxy, 1,2-dimethylpropoxy, 1-methylpentyloxy, 2-methylpentyloxy, 3-methyl Pentyloxy, 4-methylpentyloxy, 1,1-dimethylbutoxy, 1,2-dimethylbutoxy, 1,3-dimethylbutoxy, 2,2-di Methylbutoxy, 2,3-dimethylbutoxy, 3,3-dimethylbutoxy, 1-ethylbutoxy, 2-ethylbutoxy, 1,1,2- Trimethylpropoxy, 1,2,2-trimethylpropoxy, 1-ethyl-1-methylpropoxy and 1-ethyl-2-methylpropoxy and different isomers body.
根據取代基的性質，式（I）化合物可以作為不同可能的異構體形式的混合物存在，特別是立體異構體，例如E和Z，蘇式和赤式，以及旋光異構體，如果合適的話，還包括互變異構體。如果適用，式（I）的化合物包括E和Z異構體以及蘇型和赤型異構體和光學異構體、這些異構體的任何混合物和可能的互變異構形式。Depending on the nature of the substituents, the compound of formula (I) may exist as a mixture of different possible isomeric forms, especially stereoisomers, such as E and Z, threo and erythro forms, and optical isomers, if appropriate If it is, tautomers are also included. If applicable, the compound of formula (I) includes E and Z isomers as well as threo and erythro isomers and optical isomers, any mixtures of these isomers and possible tautomeric forms.
根據化合物中不對稱中心的數目，本發明的任何化合物可以以一種或多種光學、幾何或手性異構體形式存在。因此，本發明同樣涉及所有光學異構體及其外消旋或消旋混合物（術語“消旋”表示不同比例的對映體的混合物），以及所有可能的任何比例的立體異構體的混合物。非對映異構體和/或光學異構體可以根據本領域普通技術人員本身已知的方法進行分離。Depending on the number of asymmetric centers in the compound, any compound of the present invention may exist in one or more optical, geometric or chiral isomer forms. Therefore, the present invention also relates to all optical isomers and their racemic or racemic mixtures (the term "racemic" means a mixture of enantiomers in different ratios), as well as all possible mixtures of stereoisomers in any ratio . Diastereomers and/or optical isomers can be separated according to methods known per se by a person of ordinary skill in the art.
根據化合物中雙鍵的數目，本發明的任何化合物還可以以一種或多種幾何異構體形式存在。因此，本發明同樣涉及所有幾何異構體和各種比例的所有可能的混合物。幾何異構體可以根據本領域普通技術人員已知的常用方法分離。According to the number of double bonds in the compound, any compound of the present invention may also exist in one or more geometric isomer forms. Therefore, the present invention also relates to all geometric isomers and all possible mixtures in various ratios. Geometric isomers can be separated according to common methods known to those of ordinary skill in the art.
根據取代基的性質，式（I）化合物也可以以一種或多種幾何異構體形式存在，這取決於環B的取代基的相對位置（順式/式反）。本發明同樣涉及所有順式/反式異構體以及所有可能的順式/反式混合物。順式/反式異構體可以根據本領域技術人員本身已知的常用方法分離。Depending on the nature of the substituents, the compound of formula (I) may also exist in one or more geometric isomers, depending on the relative position of the substituents of ring B (cis/trans). The invention also relates to all cis/trans isomers and all possible cis/trans mixtures. The cis/trans isomers can be separated according to common methods known per se by those skilled in the art.
式（I）化合物帶有脒基，該基團可誘導基本性質。因此，這些化合物可以與酸反應生成鹽。The compound of formula (I) bears an amidino group, which can induce basic properties. Therefore, these compounds can react with acids to form salts.
無機酸的實例包括氫鹵酸，例如氟化氫、氯化氫、溴化氫和碘化氫、硫酸、磷酸和硝酸，以及酸性鹽，例如NaHSO4 和KHSO4 。Examples of inorganic acids include halogen acids such as hydrogen fluoride, hydrogen chloride, hydrogen bromide and hydrogen iodide, sulfuric acid, phosphoric acid and nitric acid, and acid salts such as NaHSO 4 and KHSO 4 .
合適的有機酸的例子有甲酸、碳酸和鏈烷酸，例如乙酸、三氟乙酸、三氯乙酸和丙酸，以及乙醇酸、硫氰酸、乳酸、琥珀酸、檸檬酸、苯甲酸、肉桂酸、草酸、烷基磺酸（具有1至20個碳原子的直鏈或支鏈烷基的磺酸）、芳基磺酸或-二磺酸（帶有一個或兩個磺酸基團的芳族基團，例如苯基和萘基）、烷基膦酸（具有1-20個碳原子的直鏈或支鏈烷基的膦酸）、芳基膦酸或-二膦酸（帶有一個或兩個膦酸基團的芳族自由基，例如苯基和萘基），其中烷基和芳基可帶有其他取代基，例如對甲苯磺酸、水楊酸、對氨基水楊酸、2-苯氧基苯甲酸、2-乙醯氧基苯甲酸等。Examples of suitable organic acids are formic acid, carbonic acid and alkanoic acid, such as acetic acid, trifluoroacetic acid, trichloroacetic acid and propionic acid, as well as glycolic acid, thiocyanic acid, lactic acid, succinic acid, citric acid, benzoic acid, cinnamic acid , Oxalic acid, alkyl sulfonic acid (a sulfonic acid with a straight or branched chain alkyl group of 1 to 20 carbon atoms), aryl sulfonic acid or-disulfonic acid (an aromatic with one or two sulfonic acid groups) Group groups such as phenyl and naphthyl), alkylphosphonic acid (phosphonic acid with a straight or branched chain alkyl group of 1-20 carbon atoms), arylphosphonic acid or -diphosphonic acid (with one Or aromatic radicals with two phosphonic acid groups, such as phenyl and naphthyl), where the alkyl and aryl groups may have other substituents, such as p-toluenesulfonic acid, salicylic acid, p-aminosalicylic acid, 2-phenoxy benzoic acid, 2-acetoxy benzoic acid, etc.
然而，上述常用術語中給出的或在優選範圍內所述的基本定義和解釋也可以根據需要彼此組合，即包括特定範圍和優選範圍之間的定義和解釋。它們既適用於最終產品，也適用於前體和中間體。此外，個別定義可能不適用。However, the basic definitions and explanations given in the above common terms or described in the preferred range can also be combined with each other as needed, that is, the definitions and explanations between the specific range and the preferred range are included. They apply to both final products and precursors and intermediates. In addition, individual definitions may not apply.
式(I)在一個實施方案中，本發明提供了一種新的，包括成分（1）和成分（2）的混合物的農用化學組合物，其中成分（1）為至少一種式（I）化合物
在一個優選的實施方案中，成分（1）是至少一種式（I）化合物
在優選的實施方案中，式（I）化合物為 (I-1) N'-(4-苄基-2-氯-5-甲基苯基)-N-乙基-N-甲基甲醯胺； (I-2) N'-(2,5-二甲基-4-(2-甲基苄基)苯基)-N-乙基-N-甲基甲醯胺； (I-3) N-乙基-N'-(5-甲氧基-2-甲基-4-(2-甲基苄基)苯基)-N-甲基甲醯胺； (I-4) N'-(4-((2-溴苯基)(甲氧基)甲基)-2,5-二甲基苯基)-N-乙基-N-甲基甲醯胺； (I-5) N'-(5-氯-4-((4-氯-3-氟苯基)(氰基)甲基)-2-甲基苯基)-N-乙基-N-甲基甲醯胺； (I-6) N'-(2-氯-4-(4-氰基苄基)-5-甲基苯基)-N-乙基-N-甲基甲醯胺； (I-7) N'-(2-氯-4-(4-甲氧基苄基)-5-甲基苯基)-N-乙基-N-甲基甲醯胺； (I-8) N'-(4-(2-氯苄基)-5-氟-2-甲基苯基)-N-乙基-N-甲基甲醯胺； (I-9) N'-(4-(3,5-二氟苄基)-2,5-二甲基苯基)-N-乙基-N-甲基甲醯胺； (I-10) N'-(2-氯-4-(2-氰基苄基)-5-甲基苯基)-N-乙基-N-甲基甲醯胺； (I-11) N'-(2-氯-4-((2-氟苯基)(氰基)甲基)-5-甲基苯基)-N-乙基-N-甲基甲醯胺； (I-12) N'-(4-(3-氯-2-氟苄基)-2,5-二甲基苯基)-N-乙基-N-甲基甲醯胺； (I-13) N'-(5-氯-4-(3-氯-2-氟苄基)-2-甲基苯基)-N-乙基-N-甲基甲醯胺； (I-14) N'-(2-氯-4-(3-氯-2-氟苄基)-5-甲基苯基)-N-乙基-N-甲基甲醯胺和 (I-15) N'-(2-氯-4-(3-氯-5-氟苄基)-5-甲基苯基)-N-乙基-N-甲基甲醯胺。In a preferred embodiment, the compound of formula (I) is (I-1) N'-(4-benzyl-2-chloro-5-methylphenyl)-N-ethyl-N-methylformamide; (I-2) N'-(2,5-Dimethyl-4-(2-methylbenzyl)phenyl)-N-ethyl-N-methylformamide; (I-3) N-ethyl-N'-(5-methoxy-2-methyl-4-(2-methylbenzyl)phenyl)-N-methylformamide; (I-4) N'-(4-((2-Bromophenyl)(methoxy)methyl)-2,5-dimethylphenyl)-N-ethyl-N-methylformamide amine; (I-5) N'-(5-chloro-4-((4-chloro-3-fluorophenyl)(cyano)methyl)-2-methylphenyl)-N-ethyl-N- Methylformamide; (I-6) N'-(2-chloro-4-(4-cyanobenzyl)-5-methylphenyl)-N-ethyl-N-methylformamide; (I-7) N'-(2-chloro-4-(4-methoxybenzyl)-5-methylphenyl)-N-ethyl-N-methylformamide; (I-8) N'-(4-(2-chlorobenzyl)-5-fluoro-2-methylphenyl)-N-ethyl-N-methylformamide; (I-9) N'-(4-(3,5-difluorobenzyl)-2,5-dimethylphenyl)-N-ethyl-N-methylformamide; (I-10) N'-(2-chloro-4-(2-cyanobenzyl)-5-methylphenyl)-N-ethyl-N-methylformamide; (I-11) N'-(2-chloro-4-((2-fluorophenyl)(cyano)methyl)-5-methylphenyl)-N-ethyl-N-methylformamide amine; (I-12) N'-(4-(3-chloro-2-fluorobenzyl)-2,5-dimethylphenyl)-N-ethyl-N-methylformamide; (I-13) N'-(5-chloro-4-(3-chloro-2-fluorobenzyl)-2-methylphenyl)-N-ethyl-N-methylformamide; (I-14) N'-(2-chloro-4-(3-chloro-2-fluorobenzyl)-5-methylphenyl)-N-ethyl-N-methylformamide and (I-15) N'-(2-Chloro-4-(3-chloro-5-fluorobenzyl)-5-methylphenyl)-N-ethyl-N-methylformamide.
在一個實施方案中，成分（2）是至少一種下列活性化合物： (A) 麥角固醇合成抑制劑， (B) 呼吸鏈複合體I或II抑制劑， (C) 呼吸鏈複合體III抑制劑， (E) 具有多重作用的化合物， (L) 核酸合成抑制劑， (M) 信號轉導抑制劑， (N) 能用作解偶聯劑的化合物， (O) 其他殺菌劑， (P) 組蛋白脫乙醯酶抑制劑， (Q) 能用作安全劑的化合物。In one embodiment, ingredient (2) is at least one of the following active compounds: (A) Ergosterol synthesis inhibitor, (B) Respiratory chain complex I or II inhibitors, (C) Respiratory chain complex III inhibitor, (E) Compounds with multiple effects, (L) Nucleic acid synthesis inhibitors, (M) Signal transduction inhibitors, (N) Compounds that can be used as uncoupling agents, (O) Other fungicides, (P) Histone deacetylase inhibitors, (Q) Compounds that can be used as safeners.
在一個優選的實施方案中，成分（2）是至少一種下列活性化合物： (A) 麥角固醇合成抑制劑， (B) 呼吸鏈複合體I或II抑制劑， (C) 呼吸鏈複合體III抑制劑， (E) 具有多重作用的化合物， (P) 組蛋白脫乙醯酶抑制劑， (Q) 能用作安全劑的化合物。In a preferred embodiment, ingredient (2) is at least one of the following active compounds: (A) Ergosterol synthesis inhibitor, (B) Respiratory chain complex I or II inhibitors, (C) Respiratory chain complex III inhibitor, (E) Compounds with multiple effects, (P) Histone deacetylase inhibitors, (Q) Compounds that can be used as safeners.
在更優選的實施方案中，成分（2）是至少一種下列活性化合物： (A) 麥角固醇合成抑制劑， (B) 呼吸鏈複合體I或II抑制劑， (C) 呼吸鏈複合體III抑制劑， (E) 具有多重作用的化合物， (P) 組蛋白脫乙醯酶抑制劑。In a more preferred embodiment, ingredient (2) is at least one of the following active compounds: (A) Ergosterol synthesis inhibitor, (B) Respiratory chain complex I or II inhibitors, (C) Respiratory chain complex III inhibitor, (E) Compounds with multiple effects, (P) Histone deacetylase inhibitor.
根據本發明的優選的新型農用化學組合物包含至少另外一種下列活性化合物（2）： (A) 麥角固醇生物合成抑制劑，例如，(A001) 環丙唑醇，(A002) 苯醚甲環唑，(A003) 氟環唑，(A004) 環醯菌胺，(A005) 苯鏽啶，(A006) 丁苯嗎啉，(A007) 胺苯吡菌酮，(A008) 氟喹唑，(A009) 粉唑醇，(A010) 抑黴唑，(A011) 硫酸抑黴唑，(A012) 種菌唑，(A013) 葉菌唑，(A014) 腈菌唑，(A015) 多效唑，(A016) 咪鮮胺，(A017) 丙環唑，(A018) 丙硫菌唑，(A019) 啶菌唑，(A020) 螺環菌胺，(A021) 戊唑醇，(A022) 氟醚唑，(A023) 三唑醇，(A024) 十三嗎啉，(A025) 滅菌唑，(A026) (1R,2S,5S)-5-(4-氯苄基)-2-(氯甲基)-2-甲基-l-(lH-1,2,4-三唑-l基甲基)環戊醇，(A027) (1S,2R,5R)-5-(4-氯苄基)-2-(氯甲基)-2-甲基-1-(1H-1,2,4-三唑-l-基甲基)環戊醇，(A028)(2R)-2-(l-氯環丙基)-4-[(1R)-2,2-二氯環丙基]-l-(lH-1,2,4-三唑-l-基)丁烷-2-醇，(A029) (2R)-2-(l-氯環丙基)-4-[(lS)-2,2-二氯環丙基]-1-(lH-1,2,4-三唑-1-基)丁烷-2-醇，(A030) (2R)-2-[4-(4-氯苯氧基)-2-(三氟甲基)苯基]-1-(1H-1,2,4-三唑-1-基)丙烷-2-醇，(A031) (2S)-2-(1-氯環丙基)-4-[(1R)-2,2-二氯環丙基]-1-(1H-l,2,4-三唑-1-基)丁烷-2-醇， (A032) (2S)-2-(1-氯環丙基)-4-[(1S)-2,2-二氯環丙基]-1-(1H-1,2,4-三唑-1-基)丁烷-2-醇，(A033) (2S)-2-[4-(4-氯苯氧基)-2-(三氟甲基)苯基]-1-(lH-1,2,4-三唑-1-基)丙烷-2-醇，(A034) (R)-[3-(4-氯-2-氟苯基)-5-(2,4-二氟苯基)-1,2-惡唑-4-基](吡啶-3-基)甲醇，(A035) (S)[3-(4-氯-2-氟苯基)-5-(2,4-二氟苯基)-l,2-惡唑-4-基](吡啶-3-基)甲醇，(A036) [3- (4-氯-2-氟苯基)-5-(2,4-二氟苯基)-1,2-惡唑-4-基](吡啶-3-基)甲醇，(A037) 1-({(2R,4S)-2-[2-氯-4-(4-氯苯氧基)苯基]-4-甲基-1,3-二氧戊環-2-基}甲基)-1H-1,2,4-三唑，(A038) 1-({(2S,4S)-2-[2-氯-4-(4-氯苯氧基)苯基]-4-甲基-l,3-二氧戊環-2-基}甲基)-lH-1,2,4-三唑，(A039)1-{[3-(2-氟苯基)-2-(2,4-二氟苯基)氧化乙烯-2-基]甲基}-lH-1,2,4-三唑-5-基 硫氰酸鹽，(A040) l-{[rel(2R,3R)-3-(2-氟苯基)-2-(2,4-二氟苯基)氧化乙烯-2-基]甲基}-1H-1,2,4-三唑-5-基 硫氰酸鹽，(A041) l-{[rel(2R,3S)-3-(2- 氟苯基)-2-(2,4-二氟苯基)氧化乙烯-2-基]甲基}-1H-1,2,4-三唑-5-基 硫氰酸鹽，(A042) 2- [(2R,4R,5R)-1-(2,4-二氟苯基)-5-羥基-2,6,6-三甲基庚烷-4-基]-2,4-二氫-3H-1,2,4-三唑-3-硫酮，(A043) 2-[(2R,4R,5S)-1-(2,4-二氟苯基)-5-羥基-2,6,6-三甲基庚烷-4-基]-2,4-二氫-3H-1,2,4-三唑-3-硫酮，(A044) 2-[(2R,4S,5R)-l-(2,4-二氟苯基)-5-羥基-2,6,6-三甲基庚烷-4-基]-2,4-二氫-3H-1,2,4-三唑-3-硫酮，(A045) 2-[(2R,4S,5S)-l-(2,4-二氟苯基)-5-羥基-2,6,6-三甲基庚烷-4-基]-2,4-二氫-3H-1,2,4-三唑-3-硫酮，(A046)2-[(2S,4R,5R)-1-(2,4-二氟苯基)-5-羥基-2,6,6-三甲基庚烷-4-基]-2,4-二氫-3H-1,2,4-三唑-3-硫酮，(A047) 2-[(2S,4R,5S)-1-(2,4-二氟苯基)-5-羥基-2,6,6-三甲基庚烷-4-基]-2,4-二氫-3H-1,2,4-三唑-3-硫酮，(A048) 2-[(2S,4S,5R)-1-(2,4-二氟苯基)-5-羥基-2,6,6-三甲基庚烷-4-基]-2,4-二氫-3H-1,2,4-三唑-3-硫酮，(A049) 2-[(2S,4S,5S)-l-(2,4-二氟苯基)-5-羥基-2,6,6-三甲基庚烷-4-基]-2,4-二氫-3H-1,2,4-三唑-3-硫酮，(A050) 2-[1-(2,4-二氟苯基)-5-羥基-2,6,6-三甲基庚烷-4-基]-2,4-二氫-3H-1,2,4-三唑-3-硫酮，(A051)2-[2-氯-4-(2,4-二氯苯氧基)苯基]-l-(1H-1,2,4-三唑-1-基)丙烷-2-醇，(A052) 2-[2-氯-4-(4-氯苯氧基)苯基]-1-(lH-1,2,4-三唑-1-基)丁烷-2-醇，(A053) 2-[4-(4-氯苯氧基)-2-(三氟甲基)苯基]-1-(lH-1,2,4-三唑-1-基)丁烷-2-醇，(A054) 2-[4-(4-氯苯氧基)-2-(三氟甲基)苯基]-1-(1H-1,2,4-三唑-l -基)戊烷-2-醇，(A055) 2-[4-(4-氯苯氧基)-2-(三氟甲基)苯基]-1-(lH-1,2,4-三唑-1-基)丙烷-2-醇，(A056) 2-{[3-(2-氟苯基)-2-(2,4-二氟苯基)氧化乙烯-2-基]甲基}-2,4-二氫-3H-l,2,4-三唑-3-硫酮，(A057) 2-{[rel(2R,3R)-3-(2-氟苯基)-2-(2,4-二氟苯基)氧化乙烯-2-基]甲基}-2,4-二氫-3H-1,2,4-三唑-3-硫酮，(A058) 2-{[rel(2R,3S)-3-(2-氟苯基)-2-(2,4-二氟苯基)氧化乙烯-2- 基]甲基}-2,4-二氫-3H-l,2,4-三唑-3-硫酮，(A059) 5-(4-氯苄基)-2-(氯甲基)-2-甲基-1-(lH-1,2,4-三唑-1-基甲基)環戊醇，(A060) 5-(烯丙基磺醯基)-1-{[3-(2-氟苯基)-2-(2,4-二氟苯基)氧化乙烯-2-基]甲基}-1H-1,2,4-三唑，(A061) 5-(烯丙基磺醯基)-1-{[rel(2R,3R)-3-2-氟苯基)-2-(2,4-二氟苯基)氧化乙烯-2-基]甲基}-1H-1,2,4-三唑，(A062) 5-(烯丙基磺醯基)-1-{[rel(2R,3S)-3-(2-氟苯基)-2-(2,4-二氟苯基)氧化乙烯-2-基]甲基}-1H-1,2,4-三唑，(A063) N'-(2,5-二甲基-4-{[3-(1,1,2,2-四氟乙氧基)苯基]磺醯基}苯基)-N-乙基-N甲基亞氨基甲醯胺，(A064) N'-(2,5-二甲基-4-{[3-(2,2,2-三氟乙氧基)苯基]磺醯基}苯基)N-乙基-N-甲基亞氨基甲醯胺，(A065) N'-(2,5-二甲基-4-{[3-(2,2,3,3-四氟丙氧基)苯基]磺醯基}苯基)-N-乙基-N-甲基亞氨基甲醯胺，(A066) N'-(2,5-二甲基-4-{[3-(五氟乙氧基)苯基]磺醯基}苯基)-N-乙基-N-甲基亞氨基甲醯胺，(A067) N'-(2,5-二甲基-4-{3-[(1,l,2,2-四氟乙基)磺醯基]苯氧基}苯基)-N-乙基-N甲基亞氨基甲醯胺，(A068) N'-(2,5-二甲基-4-{3-[(2,2,2-三氟乙基)磺醯基]苯氧基}苯基)N-乙基-N-甲基亞氨基甲醯胺，(A069) N'-(2,5-二甲基-4-{3-[(2,2,3,3-四氟丙基)磺醯基]苯氧基}苯基)-N-乙基-N-甲基亞氨基甲醯胺，(A070) N'-(2,5- 二甲基-4-{3-[(五氟乙基)磺醯基]苯氧基}苯基)-N-乙基-N-甲基亞氨基甲醯胺，(A071) N'-(2,5-二甲基-4-苯氧基苯基)-N-乙基-N-甲基亞氨基甲醯胺，(A072) N'-(4-{[3-(二氟甲氧基)苯基]磺醯基}-2,5-二甲基苯基)-N-乙基-N-甲基亞氨基甲醯胺，(A073) N'(4-{3-[(二氟甲基)磺醯基]苯氧基}-2,5-二甲基苯基)-N-乙基-N-甲基亞氨基甲醯胺，(A074) N'-[5-溴-6-(2,3-二氫-lH-茚-2-基氧基)-2-甲基吡啶-3-基]-N-乙基-N甲基亞氨基甲醯胺，(A075) N'-{4-[(4,5-二氯-1,3-噻唑-2-基)氧基]-2,5-二甲基苯基}-N乙基-N-甲基亞氨基甲醯胺，(A076) N'-{5-溴-6-[(1R)-1-(3,5-二氟苯基)乙氧基]-2-甲基吡啶-3-基}-N-乙基-N-甲基亞氨基甲醯胺，(A077) N'-{5-溴-6-[(1S)-1-(3,5-二氟苯基)乙氧基]-2-甲基吡啶-3-基}-N-乙基-N-甲基亞氨基甲醯胺，(A078) N'-{5-溴-6-[(順式-4-異丙基環己基)氧基]-2-甲基吡啶-3-基}-N-乙基-N-甲基亞氨基甲醯胺，(A079) N'-{5-溴-6-[(反式-4-異丙基環己基)氧基]-2-甲基吡啶-3-基}-N-乙基-N甲基亞氨基甲醯胺，(A080) N'-{5-溴-6-[1-(3,5-二氟苯基)乙氧基]-2-甲基吡啶-3-基}N-乙基-N-甲基亞氨基甲醯胺，(A081) 甲芬氟康唑，(A082) 氯氟醚菌唑，(A083) 1-(2,4-二氟苯基)-2-(1H-1,2,4-三唑-1-基)-1-[1-(2,6-二氟-4-氯苯氧基)環丙基]乙醇，(A084) 1-[2-(l-氯環丙基)-3-(2-氟苯基)-2-羥基丙基]-1H-咪唑-5-腈； (B) 呼吸鏈複合體I或II抑制劑，例如，(B001) 苯並烯氟菌唑，(B002) 聯苯吡菌胺，(B003) 啶醯菌胺，(B004) 萎鏽靈，(B005) 氟吡菌醯胺，(B006) 氟醯胺，(B007) 氟唑菌醯胺，(B008) 呋吡菌胺，(B009) 異丙噻菌胺，(B010) 吡唑萘菌胺 (抗差向異構體 1R,4S,9S)，(B011) 吡唑萘菌胺 (抗差向異構體1S,4R,9R)，(B012) 吡唑萘菌胺 (抗差向異構消旋體1RS,4SR,9SR)，(B013) 吡唑萘菌胺 (同差向異構消旋體混合物1RS,4SR,9RS和抗差向異構消旋體1RS,4SR,9SR)，(B014) 吡唑萘菌胺 (同差向異構體1R,4S,9R)，(B015) 吡唑萘菌胺 (同差向異構體1S,4R,9S)，(B016) 吡唑萘菌胺 (同向異構消旋體1RS,4SR,9RS)，(B017) 氟唑菌苯胺，(B018) 吡噻菌胺，(B019) 氟唑菌醯羥胺，(B020) 琥珀酸脫氫酶抑制劑，(B021) 氟唑環菌胺，(B022) 1,3-二甲基-N-(1,1,3-三甲基-2,3-二氫-lH-茚-4-基)-lH-吡唑-4-甲醯胺，(B023) 1,3-二甲基-N-[(3R)-1,l,3-三甲基-2,3-二氫-1H-茚-4-基]-1H-吡唑-4-甲醯胺，(B024) l,3-二甲基-N-[(3S)-1,1,3-三甲基-2,3-二氫-lH-茚-4-基]-1H-吡唑-4-甲醯胺，(B025) l-甲基-3-(三氟甲基)-N-[2'-(三氟甲基)bi苯基-2-基]-1H-吡唑-4-甲醯胺，(B026) 2-氟-6-(三氟甲基)-N-(1,1,3-三甲基-2,3-二氫-1H-茚-4-基)苯甲醯胺，(B027) 3-(二氟甲基)-1-甲基-N-(1,1,3-三甲基-2,3-二氫-1H-茚-4-基)-lH吡唑-4-甲醯胺，(B028) 3-(二氟甲基)-1-甲基-N-[(3R)-1,1,3-三甲基-2,3-二氫-lH茚-4-基]-lH-吡唑-4-甲醯胺 (氟蟲胺)，(B029) 3-(二氟甲基)-1-甲基-N-[(3S)-1,1,3-三甲基-2,3-二氫-lH-茚-4-基]-lH-吡唑-4-甲醯胺，(B030) 3-(二氟甲基)-N-(7-氟-1,1,3-三甲基-2,3-二氫-lH-茚-4-基)-1-甲基-1H-吡唑-4-甲醯胺 (氟茚唑菌胺)，(B031) 3-(二氟甲基)-N-[(3R)-7-氟-l,1,3-三甲基-2,3-二氫-lH-茚-4-基]-1-甲基-1H-吡唑-4-甲醯胺，(B032) 3-(二氟甲基)-N-[(3S)-7-氟-1,1,3-三甲基-2,3-二氫-1H-茚-4-基]-1-甲基-lH-吡唑-4-甲醯胺，(B033) 5,8-二氟-N-[2-(2-氟-4-{[4-(三氟甲基)吡啶-2-基]氧基}苯基)乙基]喹唑啉-4-胺，(B034) N-(2-環戊基-5-氟苄基)-N-環丙基-3-(二氟甲基)-5-氟-1-甲基-l-H-吡唑-4-甲醯胺，(B035) N-(2-叔丁基-5-甲基苄基)-N-環丙基-3-(二氟甲基)-5-氟-1-甲基-1H吡唑-4-甲醯胺，(B036) N-(2-叔丁基苄基)-N-環丙基-3-(二氟甲基)-5-氟-1-甲基-1H-吡唑-4-甲醯胺，(B037) N-(5-氯-2-乙基苄基)-N-環丙基-3-(二氟甲基)-5-氟-1-甲基-1H-吡唑-4-甲醯胺，(B038) N-(5-氯-2-異丙基苄基)-N-環丙基-3-(二氟甲基)-5-氟-1-甲基-lH-吡唑-4-甲醯胺(異氟普蘭)，(B039) N-[(1R,4S)-9-(二氯亞甲基)-1,2,3,4-四氫-1,4-甲撐萘-5-基]-3-(二氟甲基)-1-甲基-1H-吡唑-4-甲醯胺，(B040) N-[(1S,4R)-9-(二氯亞甲基)-1,2,3,4-四氫-1,4-甲撐萘-5-基]-3-(二氟甲基)-1-甲基-1H-吡唑-4-甲醯胺，(B041) N-[1-(2,4-二氟苯基)-l-甲氧基丙烷-2-基]-3-(二氟甲基)-1-甲基1H-吡唑-4-甲醯胺，(B042) N-[2-氯-6-(三氟甲基)苄基]-N-環丙基-3-(二氟甲基)-5-氟-1-甲基-1H-吡唑-4-甲醯胺，(B043) N-[3-氯-2-氟-6-(三氟甲基)苄基]-N-環丙基-3-(二氟甲基)-5-氟-1-甲基-1H-吡唑-4-甲醯胺，(B044)N-[5-氯-2-(三氟甲基)苄基]-N-環丙基-3-(二氟甲基)-5-氟-1-甲基-1H-吡唑-4-甲醯胺，(B045) N-環丙基-3-(二氟甲基)-5-氟-1-甲基-N-[5-甲基-2-(三氟甲基)苄基]-1H-吡唑-4-甲醯胺，(B046) N-環丙基-3-(二氟甲基)-5-氟-N-(2-氟-6-異丙基苄基)-1-甲基-1H-吡唑-4-甲醯胺，(B047) N-環丙基-3-(二氟甲基)-5-氟-N-(2-異丙基-5-甲基苄基)-1-甲基-1H吡唑-4-甲醯胺，(B048) N-環丙基-3-(二氟甲基)-5-氟-N-(2-異丙基苄基)-1-甲基-IH-吡唑-4-硫代醯胺，(B049) N-環丙基-3-(二氟甲基)-5-氟-N-(2-異丙基苄基)-1-甲基-1H-吡唑-4-甲醯胺，(B050) N-環丙基-3-(二氟甲基)-5-氟-N-(5-氟-2-異丙基苄基)-1-甲基-lH-吡唑-4-甲醯胺，(B051) N-環丙基-3-(二氟甲基)-N-(2-乙基-4,5-二甲基苄基)-5-氟-1-甲基-1H-吡唑-4-甲醯胺，(B052) N-環丙基-3-(二氟甲基)-N-(2-乙基-5-氟苄基)-5-氟-1-甲基-1H-吡唑-4-甲醯胺，(B053) N-環丙基-3-(二氟甲基)-N-(2-乙基-5-甲基苄基)-5-氟-1-甲基-1H-吡唑-4-甲醯胺，(B054) N-環丙基-N-(2-環丙基-5-氟苄基)-3-(二氟甲基)-5-氟-1-甲基-lH-吡唑-4-甲醯胺，(B055) N-環丙基-N-(2-環丙基-5-甲基苄基)-3-(二氟甲基)-5-氟-1-甲基-1H-吡唑-4-甲醯胺，(B056) N-環丙基-N-(2-環丙基苄基)-3-(二氟甲基)-5-氟-1-甲基-1H-吡唑-4-甲醯胺，(B057) 2-(二氟甲基)-N-(l,1-二甲基-3-丙基-2,3-二氫-1H-茚-4- 基)煙醯胺，(B058) 吡唑醯胺； (C) 呼吸鏈複合體III抑制劑，例如，(C001) 唑嘧菌胺，(C002) 吲唑磺菌胺，(C003) 腈嘧菌酯，(C004) 甲香菌酯，(C005) 丁香菌酯，(C006) 氰霜唑，(C007) 醚菌胺，(C008) 烯肟菌酯，(C009) 惡唑菌酮，(C010) 咪唑菌酮，(C011) 氟菌蟎酯，(C012) 氟嘧菌酯，(C013) 醚菌酯，(C014) 苯氧菌胺，(C015) 肟醚菌胺，(C016) 啶氧菌酯，(C017) 唑菌胺酯，(C018) 唑胺菌酯，(C019) 唑菌酯，(C020) 肟菌酯，(C021) (2E)-2-{2-[({[(1E)-1-(3-{[(E)-1-氟-2-苯基乙烯基]氧基}苯基)亞乙基]氨基}氧基)甲基]苯基}-2-(甲氧基亞氨基)-N-甲基乙醯胺，(C022) (2E,3Z)-5-{[1-(4-氟苯基)-lH-吡唑-3-基]氧基}-2-(甲氧基亞氨基)-N,3-二甲基戊基-3-烯胺，(C023) (2R)-2-{2-[(2,5-二甲基苯氧基)甲基]苯基}-2-甲氧基-N-甲基乙醯胺，(C024) (2S)-2-{2-[(2,5-二甲基苯氧基)甲基]苯基}-2-甲氧基-N-甲基乙醯胺，(C025) (3S,6S,7R,8R)-8-苄基-3-[({3-[(異丁醯氧基)甲氧基]-4-甲氧基吡啶-2-基}羰基)氨基]-6-甲基-4,9-二氧-1,5-二惡茂烷-7-基-2-丙酸甲酯(苯呱沙米)，(C026) 2-{2-[(2,5-二甲基苯氧基)甲基]苯基}-2-甲氧基-N-甲基乙醯胺(甲氧基丙烯酸酯類殺菌劑)，(C027) N-(3-乙基-3,5,5-三甲基環己基)-3-甲醯胺-2-羥基苯甲醯胺，(C028) (2E,3Z)-5-{[1-(4-氯-2-氟苯基)-lH-吡唑-3-基]氧基}-2-(甲氧基亞氨基)-N,3-二甲基戊基-3-烯胺，(C029) 甲基{5-[3-(2,4-二甲基苯基)-lH-吡唑-1-基]-2-甲基苄基}氨基甲酸酯，(C030) 1-(2-{[1-(4-氟苯基)吡唑-3-基]氧基甲基}-3-甲基苯基)-1,4-二氫-4-甲基-5H-四唑-5-酮 (本基吡唑)，(C031) 吡啶醯胺類殺菌劑； (D) 有絲分裂和細胞分裂抑制劑，例如，(D001) 多菌靈，(D002) 乙黴威，(D003) 噻唑菌胺，(D004) 氟吡菌胺，(D005) 戊菌隆，(D006) 噻苯咪唑，(D007) 甲基硫菌靈，(D008) 苯醯菌胺，(D009) 3-氯-4-(2,6-二氟苯基)-6-甲基-5-苯基噠嗪，(D010) 3-氯-5-(4-氟苯基)-4-(2,6-二氟苯基)-6-甲基噠嗪，(D011) 3-氯-5-(6-氯吡啶-3-基)-6-甲基-4-(2,4,6-三氟苯基)噠嗪，(D012) 4-(2-溴-4-氟苯基)-N-(2,6-二氟苯基)-l,3-二甲基-1H-吡唑-5-胺，(D013) 4-(2-溴-4-氟苯基)-N-(2-溴-6-氟苯基)-l,3-二甲基-1H-吡唑-5-胺，(D014) 4-(2-溴-4-氟苯基)-N-(2-溴苯基)-1,3-二甲基-lH-吡唑-5-胺，(D015)4-(2-溴-4-氟苯基)-N-(2-氯-6-氟苯基)-l,3-二甲基-1H-吡唑-5-胺，(D016) 4-(2-溴-4-氟苯基)-N-(2-氟苯基)-l,3-二甲基-1H-吡唑-5-胺，(D017)4-(2-溴-4-氟苯基)-N-(2-氟苯基)-1,3-二甲基-1H-吡唑-5-胺，(D018) 4-(2-氯-4-氟苯基)-N-(2,6-二氟苯基)-l,3-二甲基-1H-吡唑-5-胺，(D019) 4-(2-氯-4-氟苯基)-N-(2-氯-6-氟苯基)-1,3-二甲基-lH-吡唑-5-胺，(D020) 4-(2-氯-4-氟苯基)-N-(2-氟苯基)-l,3-二甲基-1H-吡唑-5-胺，(D021) 4-(2-氯-4-氟苯基)-N-(2-氟苯基)-1,3-二甲基-1H-吡唑-5-胺，(D022) 4-(4-氟苯基)-5-(2,6-二氟苯基)-3,6-二甲基噠嗪，(D023) N-(2-溴-6-氟苯基)-4-(2-氯-4-氟苯基)-l,3-二甲基-1H-吡唑-5-胺，(D024) N-(2-溴苯基)-4-(2-氯-4-氟苯基)-1,3-二甲基-1H-吡唑-5-胺，(D025) N-(4-氯-2,6-二氟苯基)-4-(2-氯-4-氟苯基)-1,3-二甲基-lH-吡唑-5-胺； (E) 具有多重作用的化合物，例如，(E001) 波爾多混合劑，(E002) 敵菌丹，(E003) 克菌丹，(E004) 百菌清，(E005) 氫氧化銅，(E006) 環烷酸銅，(E007) 氧化銅，(E008) 氯氧化銅，(E009) 硫酸銅(2+)，(E010) 二噻農，(E011) 多果定，(E012) 滅菌丹，(E013) 代森錳鋅，(E014) 代森錳，(E015) 代森聯，(E016) 代森聯鋅，(E017) 喹啉銅，(E018) 甲基代森鋅，(E019) 硫和硫製劑，包括多硫化鈣，(E020) 福美雙，(E021) 代森鋅，(E022) 福美鋅，(E023) 6-乙基-5,7-二氧-6,7-二氫-5H吡咯並[3',4':5,6][1,4]二噻農[2,3-c][1,2]噻唑-3-腈； (F) 能誘導宿主防禦的化合物，例如 (F001) 苯並噻二唑，(F002) 異噻菌胺，(F003) 噻菌靈，(F004) 噻醯菌胺； (G) 氨基酸和/或蛋白質生物合成抑制劑，例如(G001) 嘧菌環胺，(G002) 春日黴素，(G003) 春雷黴素鹽酸鹽，(G004) 土黴素，(G005) 嘧黴胺，(G006) 3-(5-氟-3,3,4,4-四甲基-3,4-二氫異喹啉-1-基)喹啉； (H) ATP生成抑制劑，例如(H001) 硫矽菌胺； (I) 細胞壁合成抑制劑，例如(I001) 苯噻菌胺，(I002) 烯醯嗎啉，(I003) 氟嗎啉，(I004) 異丙菌胺，(I005) 雙炔醯菌胺，(I006) 吡嗎啉，(I007) 纈菌胺，(I008) (2E)-3-(4-叔丁基苯基)-3-(2-氯吡啶-4-基)-l-(嗎啉-4-基)丙基-2-烯-1-酮，(I009) (2Z)-3-(4-叔丁基苯基)-3-(2-氯吡啶-4-基)-1-(嗎啉-4-基)丙基-2-烯-1-酮； (J) 脂質和膜合成抑制劑，例如(J001) 霜黴威，(J002) 霜黴威鹽酸鹽，(J003) 甲基立枯磷； (K) 黑色素生物合成抑制劑，例如 (K001) 三環唑，(K002) 2,2,2-三氟乙基{3-甲基-1-[(4-甲基苯甲醯基)氨基]丁烷-2-基}氨基甲酸酯； (L) 核酸合成抑制劑，例如(L001) 苯霜靈，(L002) 苯霜靈-M (精苯霜靈)，(L003) 甲霜靈，(L004) 甲霜靈-M (精甲霜靈)； (M) 信號轉導抑制劑，例如(M001) 咯菌腈，(M002) 異菌脲，(M003) 腐黴利，(M004) 丙氧喹啉，(M005) 喹氧靈，(M006) 乙烯菌核利； (N) 能用作解耦劑的化合物，例如(N001) 氟啶胺，(N002) 消蟎多； (O) 其他化合物，例如(O001) 脫落酸，(O002) 苯噻硫氰，(O003) 苯惡嗪，(O004) 卡巴西黴素，(O005) 香芹酮，(O006) 滅蟎猛，(O007) 硫雜靈，(O008) 環氟菌胺，(O009) 霜脲氰，(O010) 環丙磺醯胺，(O011) 氟替尼，(O012) 三乙膦酸鋁，(O013) 三乙膦酸鈣，(O014) 酸鈉，(O015) 異硫氰酸甲酯，(O016) 苯菌酮，(O017) 米多黴素，(O018) 納他黴素，(O019) 福美鎳，(O020) 酞菌酯，(O021) 惡草威，(O022) 氟噻唑吡乙酮，(O023) 氧芬硫醇，(O024) 五氯苯酚和鹽，(O025) 磷酸及其鹽類，(O026) 霜黴威乙膦酸鹽，(O027) 甲氧苯唳菌 (氯氮酮)，(O028) 異丁乙氧喹啉，(O029) 葉枯酞，(O030) 甲磺菌胺，(O031) 1-(4-{4-[(5R)-5-(2,6-二氟苯基)-4,5-二氫-l,2-惡唑-3-基]-l,3-噻唑-2-基}呱啶-1-基)-2-[5-甲基-3-(三氟甲基)-1H-吡唑-1-基]乙酮，(O032) 1-(4-{4-[(5S)-5-(2,6-二氟苯基)-4,5-二氫-l ,2-惡唑-3-基]-l,3-噻唑-2-基}呱啶-1-基)-2-[5-甲基-3-(三氟甲基)-lH-吡唑-l-基]乙酮，(O033) 2-(6-苄基吡啶-2-基)喹唑啉，(O034) 2,6-二甲基-1H,5H-[1,4]二噻農[2,3-c:5,6-c']二吡咯-1,3,5,7(2H,6H)-四酮，(O035) 2-[3,5-雙(二氟甲基)-lH-吡唑-1-基]-1-[4-(4-{5-[2-(丙基-2-炔-1-基氧基)苯基]-4,5-二氫-l,2-惡唑-3-基}-l,3-噻唑-2-基)呱啶-1-基]乙酮，(O036) 2-[3,5-雙(二氟甲基)-1H-吡唑-1-基]-1-[4-(4-{5-[2-氯-6-(丙基-2-炔-1-基氧基)苯基]-4,5-二氫-1,2-惡唑-3-基}-1,3-噻唑-2-基)呱啶-1-基]乙酮，(O037) 2-[3,5-雙(二氟甲基)-lH-吡唑-1-基]-1-[4-(4-{5-[2-氟-6-(丙基-2-炔-1-基氧基)苯基]-4,5-二氫- l,2-惡唑-3-基}-l,3-噻唑-2-基)呱啶-1-基]乙酮，(O038) 2-[6-(3-氟-4-甲氧基苯基)-5-甲基吡啶-2-基]喹唑啉，(O039) 2-{(5R)-3-[2-(1-{[3,5-雙(二氟甲基)-lH-吡唑-1-基]乙醯基}呱啶-4-基)-1,3-噻唑-4-基]-4,5-二氫-l,2-惡唑-5-基}-3-氟苯基 甲磺酸鹽，(O040) 2-{(5S)-3-[2-(1-{[3,5-雙(二氟甲基)-1H-吡唑-1-基]乙醯基}呱啶-4-基)-1,3-噻唑-4-基]-4,5-二氫-1,2-惡唑-5-基}-3-氟苯基 甲磺酸鹽，(O041) 2-{2-[(7,8-二氟-2-甲基喹啉-3-基)氧基]-6-氟苯基}丙烷-2-醇，(O042) 2-{2-氟-6-[(8-氟-2-甲基喹啉-3-基)氧基]苯基}丙烷-2-醇，(O043) 2-{3-[2-(1-{[3,5-雙(二氟甲基)-1H-吡唑-1-基]乙醯基}呱啶-4-基)-1,3-噻唑-4-基]-4,5-二氫-1,2-惡唑-5-基}-3-氟苯基 甲磺酸鹽 (拜耳“奇葩”殺菌劑)，(O044)2-{3-[2-(1-{[3,5-雙(二氟甲基)-1H-吡唑-1-基]乙醯基}呱啶-4-基)-1,3-噻唑-4-基]-4,5-二氫-1,2-惡唑-5-基}苯基 甲磺酸鹽，(O045) 2-苯基苯酚和鹽，(O046) 3-(4,4,5-三氟-3,3-二甲基-3,4-二氫異喹啉-1-基)喹啉，(O047) 3-(4,4-二氟-3,3-二甲基-3,4-二氫異喹啉-1-基)喹啉 (喹啉類殺菌劑)，(O048) 4-氨基-5-氟嘧啶-2-醇 (互變異構體: 4-氨基-5- 氟嘧啶-2(1H)-酮)，(O049) 4-氧代-4-[(2-苯基乙基)氨基]丁酸，(O050) 5-氨基-1,3,4-噻二唑-2-硫醇，(O051) 5-氯-N'-苯基-N'-(丙基-2-炔-1-基)噻吩-2-磺醯肼，(O052) 5-氟-2-[(4-氟苄基)氧基]嘧啶-4-胺，(O053) 5-氟-2-[(4-甲基苄基)氧基]嘧啶-4-胺,(O054) 9-氟-2,2-二甲基-5-(喹啉-3-基)-2,3-二氫-1,4-苯氧氮平，(O055) 丁-3-炔-1-基{6-[({[(Z)-(l-甲基-1H-四唑-5-基)(苯基)亞甲基]氨基}氧基)甲基]吡啶-2-基}氨基甲酸酯，(O056) 乙基(2Z)-3-氨基-2-氰基-3-丙烯酸苯酯，(O057) 吩嗪-1-羧酸，(O058) 丙基 3,4,5-三羥基苯甲酯，(O059) 喹啉-8-醇，(O060) 喹啉-8-醇 硫酸鹽 (2:1)，(O061) 叔丁基{6-[({[(1-甲基-1H-四唑-5-基)(苯基)亞甲基]氨基}氧基)甲基]吡啶-2-基}氨基甲酸酯，(O062) 5-氟-4-亞氨基-3-甲基-1-[(4-甲基苯基)磺醯基]-3,4-二氫嘧啶-2(1H)-酮，(O063) 吡啶氯甲基，(O064) 異氟苯諾喹，(O065) 廣譜吡啶類殺菌劑。 (P) 組蛋白去乙醯化酶抑制劑，例如 (P001) N-(1-乙基環丙基)-4-[5-(三氟甲基)-1,2,4-惡二唑-3-基]苯甲醯胺；(P002) N-(2-異丙基環丙基)-4-[5-(三氟甲基)-1,2,4-惡二唑-3-基]苯甲醯胺；(P003) N-(2-甲基環丙基)-4-[5-(三氟甲基)-1,2,4-惡二唑-3-基]苯甲醯胺；(P004) N-(1-甲基環丙基)-4-[5-(三氟甲基)-1,2,4-惡二唑-3-基]苯甲醯胺；(P005) N-(2-乙基環丙基)-4-[5-(三氟甲基)-1,2,4-惡二唑-3-基]苯甲醯胺；(P006) N-(2,4-二氟苯基)-4-[5-(三氟甲基)-1,2,4-惡二唑-3-基]苯甲醯胺；(P007) 5-(三氟甲基)-3-[4-[[3-(三氟甲基)-1,2,4triazol-1-基]甲基]苯基]-1,2,4-惡二唑；(P008) 2-[[4-[5-(三氟甲基)-1,2,4-惡二唑-3-基]苯基]甲基]-1,2,4-三唑-3-腈；(P009) 乙基1-[[4-[5-(三氟甲基)-1,2,4-惡二唑-3-基]苯基]甲基]吡唑-4-羧酸鹽；(P010) N-環丙基-1-[[4-[5-(三氟甲基)-1,2,4-惡二唑-3-基]苯基]甲基]吡唑-4-甲醯胺；(P011) N,N-二甲基-1-[[4-[5-(三氟甲基)-1,2,4-惡二唑-3-基]苯基]甲基]吡唑-4-甲醯胺；(P012) N-甲基-1-[[4-[5-(三氟甲基)-1,2,4-惡二唑-3-基]苯基]甲基]吡唑-4-甲醯胺；(P013) N,N,-二甲基-H[4-[5-(三氟甲基)-1,2,4-惡二唑-3-基]苯基]甲基]-1,2,4-三唑-3-胺；(P014) 3-[4-[(5-乙基磺醯基-1,2,4-三唑-1-基)甲基]苯基]-5-(三氟甲基)-1,2,4-惡二唑；(P015) 3-[4-(三唑[4,5-b]吡啶-1-基甲基)苯基]-5-(三氟甲基)-1,2,4-惡二唑；(P016) 3-[4-(三唑[4,5-b]吡啶-2-基甲基)苯基]-5-(三氟甲基)-1,2,4-惡二唑；(P017) 3-[4-(三唑[4,5-b]吡啶-3-基甲基)苯基]-5-(三氟甲基)-1,2,4-惡二唑；(P018) 甲基 1-[[4-[5-(三氟甲基)-1,2,4-惡二唑-3-基]苯基]甲基]吡唑-4-羧酸鹽；(P019) 1-[[3-氟-4-[5-(三氟甲基)-1 ,2,4-惡二唑-3-基]苯基]甲基]吡唑-4-羧酸乙酯；(P020)N,N- 二乙基-1-[[4-[5-(三氟甲基)-1,2,4-惡二唑-3-基]苯基]甲基]吡唑-4-甲醯胺；(P021)N -甲氧基-N -甲基-1-[[4-[5-(三氟甲基)-1,2,4-惡二唑-3-基]苯基]甲基]吡唑-4-甲醯胺；(P022) 丙基 1-[[4-[5-(三氟甲基)-1,2,4-惡二唑-3-基]苯基]甲基]吡唑-4-羧酸鹽；(P023)N -甲氧基-1-[[4-[5-(三氟甲基)-1,2,4-惡二唑-3-基]苯基]甲基]吡唑-4-甲醯胺；(P024)N -乙基-1-[[4-[5-(三氟甲基)-1,2,4-惡二唑-3-基]苯基]甲基]吡唑-4-甲醯胺；(P025) 1-[[4-[5-(三氟甲基)-1,2,4-惡二唑-3-基]苯基]甲基]吡唑-4-甲醯胺；(P026)N -甲氧基-1-[1-[[4-[5-(三氟甲基)-1,2,4-惡二唑-3-基]苯基]甲基]吡唑-4-基]亞胺；(P027) 乙基 1-[1-[4-[5-(三氟甲基)-1,2,4-惡二唑-3-基]苯基]乙基]吡唑-4-羧酸鹽；(P028) 1-[[4-[5-(三氟甲基)-1,2,4-惡二唑-3-基]苯基]甲基]吡咯烷-2-酮；(P029) 1-[[4-[5-(三氟甲基)-1,2,4-惡二唑-3-基]苯基]甲基]呱啶-2-酮；(P030) 4-[[4-[5-(三氟甲基)-1,2,4-惡二唑-3-基]苯基]甲基]嗎啉-3-酮；(P031) 4,4-二甲基-2-[[4-[5-(三氟甲基)-1,2,4-惡二唑-3-基]苯基]甲基]異惡唑啉-3-酮；(P032) 2-[[4-[5-(三氟甲基)-1,2,4-惡二唑-3-基]苯基]甲基]異惡唑啉-3-酮；(P033) 5,5-二甲基-2-[[4-[5-(三氟甲基)-1,2,4-惡二唑-3-基]苯基]甲基]異惡唑啉-3-酮；(P034) 3,3-二甲基-1 [4-[5-(三氟甲基)-1,2,4-惡二唑-3-基]苯基]甲基]呱啶-2-酮；(P035) 1-[[2-氟-4-[5-(三氟甲基)-1,2,4-惡二唑-3-基]苯基]甲基]吡咯烷-2-酮；(P036) 1-[[2-氟-4-[5-(三氟甲基)-1,2,4-惡二唑-3-基]苯基]甲基]呱啶-2-酮；(P037) 2-[[4-[5-(三氟甲基)-1,2,4-惡二唑-3-基]苯基]甲基]惡嗪-3-酮；(P038) 1-[[3-氟-4-[5-(三氟甲基)-1,2,4-惡二唑-3-基]苯基]甲基]呱啶-2-酮；(P039) 3-[[4-[5-(三氟甲基)-1,2,4-惡二唑-3-基]苯基]甲基]唑烷-2-酮；(P040) 1-甲基-3-[[4-[5-(三氟甲基)-1,2,4-惡二唑-3-基]苯基]甲基]咪唑啉啶-2-酮；(P041) 1-[[3-氟-4-[5-(三氟甲基)-1,2,4-惡二唑-3-基]苯基]甲基]-3,3-二甲基-呱啶-2-酮；(P042) 1-[[3-氟-4-[5-(三氟甲基)-1,2,4-惡二唑-3-基]苯基]甲基]吡咯烷-2-酮；(P043) 2-[[3-氟-4-[5-(三氟甲基)-1,2,4-惡二唑-3-基]苯基]甲基]-4,4-二甲基-異惡唑啉-3-酮；(P044) 2-[[2,3-二氟-4-[5-(三氟甲基)-1,2,4-惡二唑-3-基]苯基]甲基]異惡唑啉-3-酮；(P045) 2-[[3-氟-4-[5-(三氟甲基)-1,2,4-惡二唑-3-基]苯基]甲基]異惡唑啉-3-酮；(P046) 1-[[3-氟-4-[5-(三氟甲基)-1,2,4-惡二唑-3-基]苯基]甲基]氮雜烷-2-酮；(P047) N-[[4-[5-(三氟甲基)-1,2,4-惡二唑-3-基]苯基]甲基]丙醯胺；(P048) 2,2-二甲基-N-[[4-[5-(三氟甲基)-1,2,4-惡二唑-3-基]苯基]甲基]丁基-3-炔醯胺；(P049) N-[[4-[5-(三氟甲基)-1,2,4-惡二唑-3-基]苯基]甲基]丁醯胺；(P050) 3-甲基-N-[[4-[5-(三氟甲基)-1,2,4-惡二唑-3-基]苯基]甲基]丁醯胺；(P051) 2-甲基-N-[[4-[5-(三氟甲基)-1,2,4-惡二唑-3-基]苯基]甲基]丙基-2-烯胺；(P052) 2-甲基-N-[[4-[5-(三氟甲基)-1,2,4-惡二唑-3-基]苯基]甲基]丁醯胺；(P053) 2-甲氧基-N-[[4-[5-(三氟甲基)-1,2,4-惡二唑-3-基]苯基]甲基]；(P054) 3,3,3-三氟-N-[[3-氟-4-[5-(三氟甲基)-1,2,4-惡二唑-3-基]苯基]甲基]丙醯胺；(P055) 3,3,3-三氟-N-[[2-氟-4-[5-(三氟甲基)-1,2,4-惡二唑-3-基]苯基]甲基]丙醯胺；(P056) N-[[2,3-二氟-4-[5-(三氟甲基)-1,2,4-惡二唑-3-基]苯基]甲基]丁醯胺；(P057) N-[[2,3-二氟-4-[5-(三氟甲基)-1,2,4-惡二唑-3-基]苯基]甲基]-3,3,3-三氟-丙醯胺；(P058) 2-(二氟甲氧基)-N-[[4-[5-(三氟甲基)-1,2,4-惡二唑-3-基]苯基]甲基]乙醯胺；(P059) 2-甲氧基-2-甲基-N-[[4-[5-(三氟甲基)-1,2,4-惡二唑-3-基]苯基]甲基]丙醯胺；(P060) 1-甲基-3-[[4-[5-(三氟甲基)-1,2,4-惡二唑-3-基]苯基]甲基]脲；(P061) 1-乙基-1-甲基-3-[[4-[5-(三氟甲基)-1,2,4-惡二唑-3-基]苯基]甲基]脲；(P062) 1-乙氧基-3-[[4-[5-(三氟甲基)-1,2,4-惡二唑-3-基]苯基]甲基]脲；(P063) 1-甲氧基-1-甲基-3-[[4-[5-(三氟甲基)-1,2,4-惡二唑-3-基]苯基]甲基]；(P064) 1,1-二乙基-3-[[4-[5-(三氟甲基)-1 ,2,4-惡二唑-3-基]苯基]甲基]脲；(P065) N-甲氧基-N-[[4-[5-(三氟甲基)-1,2,4-惡二唑-3-基]苯基]甲基]環丙烷甲醯胺；(P066) N-甲氧基-N-[[4-[5-(三氟甲基)-1,2,4-惡二唑-3-基]苯基]甲基] 戊基-4-炔醯胺；(P067) N-甲氧基-2-甲基-N-[[4-[5-(三氟甲基)-1,2,4-惡二唑-3-基]苯基]甲基]丙基-2-烯胺；(P068) N,2-二甲氧基-N-[[4-[5-(三氟甲基)-1,2,4-惡二唑-3-基]苯基]甲基]丙醯胺；(P069) N-環丙基-3,3,3-三氟-N-[[4-[5-(三氟甲基)-1,2,4-惡二唑-3-基]苯基]甲基]丙醯胺；(P070) 2,2-二氟-N-(2-甲氧基乙基)-N-[[4-[5-(三氟甲基)-1,2,4-惡二唑-3-基]苯基]甲基]環丙烷甲醯胺；(P071) N-乙基-2-甲基-N-[[4-[5-(三氟甲基)-1,2,4-惡二唑-3-基]苯基]甲基]丙醯胺；(P072) N-[[3-氟-4-[5-(三氟甲基)-1,2,4-惡二唑-3-基]苯基]甲基]-N-甲氧基-丙醯胺；(P073) 2-甲氧基-N-(2,2,2-三氟乙基)-N-[[4-[5-(三氟甲基)-1,2,4-惡二唑-3-基]苯基]甲基] 乙醯胺；(P074) N-[[2,3-二氟-4-[5-(三氟甲基)-1,2,4-惡二唑-3-基]苯基]甲基]-N-甲氧基-環丙烷甲醯胺；(P075) 2-(二氟甲氧基)-N-甲基-N-[[4-[5-(三氟甲基)-1,2,4-惡二唑-3-基]苯基]甲基]乙醯胺；(P076) N-乙氧基-2-甲氧基-N-[[4-[5-(三氟甲基)-1,2,4-惡二唑-3-基]苯基]甲基]丙醯胺；(P077) N-異丙基-N-[[4-[5-(三氟甲基)-1,2,4-惡二唑-3-基]苯基]甲基]四氫呋喃-2-甲醯胺；(P078) 1-甲氧基-3-甲基-1-[[4-[5-(三氟甲基)-1,2,4-惡二唑-3-基]苯基]甲基]脲；(P079) 3-環丙基-1-甲氧基-1-[[4-[5-(三氟甲基)-1,2,4-惡二唑-3-基]苯基]甲基]脲；(P080) 3-乙氧基-1-甲氧基-1-[[4-[5-(三氟甲基)-1,2,4-惡二唑-3-基]苯基]甲基]脲；(P081) 3-烯丙基-1-甲氧基-1-[[4-[5-(三氟甲基)-1,2,4-惡二唑-3-基]苯基]甲基]脲；(P082) 1-環丙基-3-甲氧基-3-甲基-1-[[4-[5-(三氟甲基)-1,2,4-惡二唑-3-基]苯基]甲基]脲；(P083) 3-異丙基-1-甲氧基-1-[[4-[5-(三氟甲基)-1,2,4-惡二唑-3-基]苯基]甲基]脲；(P084) 1-甲氧基-3-丙基-2-炔基-1-[[4-[5-(三氟甲基)-1,2,4-惡二唑-3-基]苯基]甲基]脲；(P085) 1-[[3-氟-4-[5-(三氟甲基)-1,2,4-惡二唑-3-基]苯基]甲基]-1-甲氧基-3-甲基-脲；(P086) 3-(環丙基甲基)-1-甲基-1-[[4-[5-(三氟甲基)-1,2,4-惡二唑-3-基]苯基]甲基]脲；(P087) 1-乙基-3-(2,2,2-三氟乙基)-1-[[4-[5-(三氟甲基)-1,2,4-惡二唑-3- 基]苯基]甲基]脲；(P088) 1,3-二甲氧基-1-[[4-[5-(三氟甲基)-1,2,4-惡二唑-3-基]苯基]甲基]脲；(P089) 3-乙基-1-甲氧基-1-[[4-[5-(三氟甲基)-1,2,4-惡二唑-3-基]苯基]甲基]脲；(P090) N-甲基-4-[5-(三氟甲基)-1,2,4-惡二唑-3-基]苯甲醯胺；(P091) N-[(E)-甲氧基亞氨基甲基]-4-[5-(三氟甲基)-1,2,4-惡二唑-3-基]苯甲醯胺；(P092) N-[(Z)-甲氧基亞氨基甲基]-4-[5-(三氟甲基)-1,2,4-惡二唑-3-基]苯甲醯胺；(P093) N-[4-[5-(三氟甲基)-1,2,4-惡二唑-3-基]苯基]環丙烷甲醯胺；(P094) N-(2-氟苯基)-4-[5-(三氟甲基)-1,2,4-惡二唑-3-基]苯甲醯胺；(P095) 2,2-二氟-N-甲基-2-[4-[5-(三氟甲基)-1,2,4-惡二唑-3-基]苯基]乙醯胺；(P096) N-烯丙基-N-[[4-[5-(三氟甲基)-1,2,4-惡二唑-3-基]苯基]甲基]乙醯胺；(P097) N-[(E)-N-甲氧基-C-甲基-碳亞氨基]-4-[5-(三氟甲基)-1,2,4-惡二唑-3-基]苯甲醯胺；(P098) N-[(Z)-N-甲氧基-C-甲基-碳亞氨基]-4-[5-(三氟甲基)-1,2,4-惡二唑-3-基]苯甲醯胺；(P100) N-烯丙基-N-[[4-[5-(三氟甲基)-1,2,4-惡二唑-3-基]苯基]甲基]丙醯胺；(P101) 4,4-二甲基-1-[[4-[5-(三氟甲基)-1,2,4-惡二唑-3-基]苯基]甲基]吡咯烷-2-酮；(P102) N-甲基-4-[5-(三氟甲基)-1,2,4-惡二唑-3-基]苯甲硫醯胺；(P103) 5-甲基-1-[[4-[5-(三氟甲基)-1,2,4-惡二唑-3-基]苯基]甲基]吡咯烷-2-酮；(P104) N-甲基-4-[5-(三氟甲基)-1,2,4-惡二唑-3-基]苯甲甲醯胺；(P105) N1-甲基-N2-(4-(5-(三氟甲基)-1,2,4-惡二唑-3-基)苄基)草醯胺。The preferred novel agrochemical composition according to the present invention contains at least one of the following active compounds (2): (A) an ergosterol biosynthesis inhibitor, for example, (A001) cyproconazole, (A002) fenoxylate Cycloconazole, (A003) epoxiconazole, (A004) fenpropidin, (A005) fenpropidin, (A006) fenpropimorph, (A007) fenpyridone, (A008) fluquinazole, ( A009) Fenconazole, (A010) imazalil, (A011) imazalil sulfate, (A012) pyriconazole, (A013) metconazole, (A014) myclobutanol, (A015) paclobutrazol, (A016) imidazole Cantamine, (A017) propiconazole, (A018) prothioconazole, (A019) pyriconazole, (A020) spiriconazole, (A021) tebuconazole, (A022) flufenconazole, (A023) Triadimenol, (A024) Tridecamorph, (A025) Triazole, (A026) (1R,2S,5S)-5-(4-chlorobenzyl)-2-(chloromethyl)-2-methan Group-l-(lH-1,2,4-triazol-1-methyl)cyclopentanol, (A027) (1S,2R,5R)-5-(4-chlorobenzyl)-2-(chloro Methyl)-2-methyl-1-(1H-1,2,4-triazol-1-ylmethyl)cyclopentanol, (A028)(2R)-2-(l-chlorocyclopropyl) -4-[(1R)-2,2-Dichlorocyclopropyl]-l-(lH-1,2,4-triazol-1-yl)butan-2-ol, (A029) (2R) -2-(l-chlorocyclopropyl)-4-[(lS)-2,2-dichlorocyclopropyl]-1-(lH-1,2,4-triazol-1-yl)butane -2-ol, (A030) (2R)-2-[4-(4-chlorophenoxy)-2-(trifluoromethyl)phenyl]-1-(1H-1,2,4-tri Azol-1-yl)propan-2-ol, (A031) (2S)-2-(1-chlorocyclopropyl)-4-[(1R)-2,2-dichlorocyclopropyl]-1- (1H-l,2,4-triazol-1-yl)butan-2-ol, (A032) (2S)-2-(1-chlorocyclopropyl)-4-[(1S)-2, 2-Dichlorocyclopropyl]-1-(1H-1,2,4-triazol-1-yl)butan-2-ol, (A033) (2S)-2-[4-(4-chloro Phenoxy)-2-(trifluoromethyl)phenyl]-1-(lH-1,2,4-triazol-1-yl)propan-2-ol, (A034) (R)-[3 -(4-Chloro-2-fluorophenyl)-5-(2,4-difluorophenyl)-1,2-oxazol-4-yl](pyridin-3-yl)methanol, (A035) ( S)[3-(4-chloro-2-fluorophenyl)-5-(2,4-difluorophenyl)-l,2-oxazol-4-yl](pyridin-3-yl)methanol, (A 036) [3-(4-Chloro-2-fluorophenyl)-5-(2,4-difluorophenyl)-1,2-oxazol-4-yl](pyridin-3-yl)methanol, (A037) 1-(((2R,4S)-2-(2-chloro-4-(4-chlorophenoxy)phenyl)-4-methyl-1,3-dioxolane-2- Yl}methyl)-1H-1,2,4-triazole, (A038) 1-({(2S,4S)-2-[2-chloro-4-(4-chlorophenoxy)phenyl] -4-methyl-l,3-dioxolane-2-yl}methyl)-lH-1,2,4-triazole, (A039)1-{[3-(2-fluorophenyl) -2-(2,4-Difluorophenyl)oxyethylene-2-yl]methyl}-lH-1,2,4-triazol-5-yl thiocyanate, (A040) l-{[ rel(2R,3R)-3-(2-fluorophenyl)-2-(2,4-difluorophenyl)oxyethylene-2-yl)methyl)-1H-1,2,4-triazole -5-yl thiocyanate, (A041) l-{[rel(2R,3S)-3-(2-fluorophenyl)-2-(2,4-difluorophenyl)ethylene oxide-2- Yl]methyl}-1H-1,2,4-triazol-5-yl thiocyanate, (A042) 2- [(2R,4R,5R)-1-(2,4-difluorophenyl )-5-hydroxy-2,6,6-trimethylheptan-4-yl]-2,4-dihydro-3H-1,2,4-triazole-3-thione, (A043) 2 -[(2R,4R,5S)-1-(2,4-difluorophenyl)-5-hydroxy-2,6,6-trimethylheptan-4-yl]-2,4-dihydro -3H-1,2,4-Triazole-3-thione, (A044) 2-[(2R,4S,5R)-l-(2,4-difluorophenyl)-5-hydroxy-2, 6,6-Trimethylheptan-4-yl]-2,4-dihydro-3H-1,2,4-triazole-3-thione, (A045) 2-[(2R,4S,5S )-l-(2,4-Difluorophenyl)-5-hydroxy-2,6,6-trimethylheptan-4-yl)-2,4-dihydro-3H-1,2,4 -Triazole-3-thione, (A046)2-[(2S,4R,5R)-1-(2,4-difluorophenyl)-5-hydroxy-2,6,6-trimethylheptane Alkyl-4-yl]-2,4-dihydro-3H-1,2,4-triazole-3-thione, (A047) 2-[(2S,4R,5S)-1-(2,4 -Difluorophenyl)-5-hydroxy-2,6,6-trimethylheptan-4-yl)-2,4-dihydro-3H-1,2,4-triazole-3-thione , (A048) 2-[(2S,4S,5R)-1-(2,4-difluorophenyl)-5-hydroxy-2,6,6-trimethylheptan-4-yl]-2 ,4-Dihydro-3H-1,2,4-triazole-3-thione, (A049) 2-[(2S,4 S,5S)-l-(2,4-difluorophenyl)-5-hydroxy-2,6,6-trimethylheptan-4-yl)-2,4-dihydro-3H-1, 2,4-Triazole-3-thione, (A050) 2-[1-(2,4-difluorophenyl)-5-hydroxy-2,6,6-trimethylheptan-4-yl ]-2,4-Dihydro-3H-1,2,4-triazole-3-thione, (A051)2-[2-chloro-4-(2,4-dichlorophenoxy)phenyl ]-l-(1H-1,2,4-triazol-1-yl)propan-2-ol, (A052) 2-[2-chloro-4-(4-chlorophenoxy)phenyl]- 1-(lH-1,2,4-triazol-1-yl)butan-2-ol, (A053) 2-[4-(4-chlorophenoxy)-2-(trifluoromethyl) Phenyl]-1-(lH-1,2,4-triazol-1-yl)butan-2-ol, (A054) 2-[4-(4-chlorophenoxy)-2-(three Fluoromethyl)phenyl]-1-(1H-1,2,4-triazol-1-yl)pentane-2-ol, (A055) 2-[4-(4-chlorophenoxy)- 2-(Trifluoromethyl)phenyl]-1-(lH-1,2,4-triazol-1-yl)propan-2-ol, (A056) 2-{[3-(2-Fluorobenzene Yl)-2-(2,4-difluorophenyl)oxyethylene-2-yl]methyl}-2,4-dihydro-3H-1,2,4-triazole-3-thione, ( A057) 2-{(rel(2R,3R)-3-(2-fluorophenyl)-2-(2,4-difluorophenyl)oxyethylene-2-yl)methyl)-2,4- Dihydro-3H-1,2,4-triazole-3-thione, (A058) 2-{[rel(2R,3S)-3-(2-fluorophenyl)-2-(2,4- Difluorophenyl)oxyethylene-2-yl]methyl}-2,4-dihydro-3H-1,2,4-triazole-3-thione, (A059) 5-(4-chlorobenzyl )-2-(chloromethyl)-2-methyl-1-(lH-1,2,4-triazol-1-ylmethyl)cyclopentanol, (A060) 5-(allylsulfonyl Yl)-1-{[3-(2-fluorophenyl)-2-(2,4-difluorophenyl)oxyethylene-2-yl]methyl}-1H-1,2,4-triazole , (A061) 5-(allylsulfonyl)-1-{[rel(2R,3R)-3-2-fluorophenyl)-2-(2,4-difluorophenyl)ethylene oxide- 2-yl]methyl}-1H-1,2,4-triazole, (A062) 5-(allylsulfonyl)-1-{[rel(2R,3S)-3-(2-fluoro Phenyl)-2-(2,4-difluorophenyl)oxyethylene-2-yl]methyl}-1H-1,2,4-triazole, (A063) N'-(2,5-di Methyl-4-{[3-(1,1,2,2-tetrafluoroethoxy)phenyl]sulfonyl}phenyl)-N-ethyl-Nmethylimino Formamide, (A064) N'-(2,5-dimethyl-4-{[3-(2,2,2-trifluoroethoxy)phenyl]sulfonyl}phenyl)N- Ethyl-N-methyliminocarboxamide, (A065) N'-(2,5-dimethyl-4-{[3-(2,2,3,3-tetrafluoropropoxy)benzene (A066) N'-(2,5-dimethyl-4-{[3-(pentafluoroethyl)] Sulfonyl}phenyl)-N-ethyl-N-methyliminomethanamide (Oxy)phenyl]sulfonyl}phenyl)-N-ethyl-N-methyliminomethanamide, (A067) N'-(2,5-dimethyl-4-{3-[ (1,1,2,2-Tetrafluoroethyl)sulfonyl]phenoxy}phenyl)-N-ethyl-Nmethyliminomethamide, (A068) N'-(2,5 -Dimethyl-4-{3-[(2,2,2-trifluoroethyl)sulfonyl]phenoxy}phenyl)N-ethyl-N-methyliminomethanamide, ( A069) N'-(2,5-Dimethyl-4-{3-[(2,2,3,3-tetrafluoropropyl)sulfonyl]phenoxy)phenyl)-N-ethyl -N-Methyliminomethanamide, (A070) N'-(2,5-Dimethyl-4-{3-[(pentafluoroethyl)sulfonyl]phenoxy}phenyl)- N-ethyl-N-methyliminoformamide, (A071) N'-(2,5-dimethyl-4-phenoxyphenyl)-N-ethyl-N-methylimino Formamide, (A072) N'-(4-{[3-(difluoromethoxy)phenyl]sulfonyl}-2,5-dimethylphenyl)-N-ethyl-N- Methyliminocarbamide, (A073) N'(4-{3-[(difluoromethyl)sulfonyl]phenoxy}-2,5-dimethylphenyl)-N-ethyl -N-Methyliminomethanamide, (A074) N'-[5-Bromo-6-(2,3-dihydro-lH-inden-2-yloxy)-2-methylpyridine-3 -Yl]-N-ethyl-N methyliminocarbamide, (A075) N'-{4-[(4,5-dichloro-1,3-thiazol-2-yl)oxy]- 2,5-Dimethylphenyl}-Nethyl-N-methyliminocarboxamide, (A076) N'-{5-bromo-6-[(1R)-1-(3,5- Difluorophenyl)ethoxy]-2-methylpyridin-3-yl}-N-ethyl-N-methyliminoformamide, (A077) N'-{5-bromo-6-[ (1S)-1-(3,5-Difluorophenyl)ethoxy]-2-methylpyridin-3-yl}-N-ethyl-N-methyliminomethamide, (A078) N'-{5-Bromo-6-[(cis-4-isopropylcyclohexyl)oxy]-2-methylpyridin-3-yl}-N-ethyl-N-methyliminomethyl Amide, (A079) N'-{5-bromo-6-[(trans-4-isopropylcyclohexyl)oxy]-2-methylpyridin-3-yl}-N-ethyl-N Methyl iminoformamide, (A080) N'-(5-Bromo-6-[1-(3,5-difluorophenyl)ethoxy]-2-methylpyridin-3-yl)N-ethyl-N-methyl Iminomethamide, (A081) Mefenfluconazole, (A082) Clofluconazole, (A083) 1-(2,4-Difluorophenyl)-2-(1H-1,2,4 -Triazol-1-yl)-1-[1-(2,6-difluoro-4-chlorophenoxy)cyclopropyl]ethanol, (A084) 1-[2-(l-chlorocyclopropyl) )-3-(2-Fluorophenyl)-2-hydroxypropyl]-1H-imidazole-5-carbonitrile; (B) Inhibitors of respiratory chain complex I or II, for example, (B001) Benzoene fluobacterium Azole, (B002) bixafen, (B003) flufenoxan, (B004) cyprofen, (B005) fluopyram, (B006) flufenamide, (B007) flufenoxamide , (B008) Furapyrad, (B009) Prothiosamide, (B010) Pyraclostrobin (anti-epimer 1R, 4S, 9S), (B011) Pyraclostrobin (anti- Epimers 1S, 4R, 9R), (B012) Pyraclostrobin (antiepimer 1RS, 4SR, 9SR), (B013) Pyraclostrobin (Epimers) Racemate mixture 1RS, 4SR, 9RS and anti-epimerized racemates 1RS, 4SR, 9SR), (B014) Pyraclostrobin (epimers 1R, 4S, 9R), (B015) Pyraclostrobin (epimers 1S, 4R, 9S), (B016) Pyraclostrobin (racemates 1RS, 4SR, 9RS), (B017) Fluconazole, (B018) Pyraclostrobin, (B019) Fluconazole hydroxylamine, (B020) Succinate dehydrogenase inhibitor, (B021) Flufenoxanil, (B022) 1,3-Dimethyl-N- (1,1,3-Trimethyl-2,3-dihydro-1H-inden-4-yl)-1H-pyrazole-4-carboxamide, (B023) 1,3-dimethyl-N -[(3R)-1,l,3-Trimethyl-2,3-dihydro-1H-inden-4-yl]-1H-pyrazole-4-carboxamide, (B024) 1,3- Dimethyl-N-[(3S)-1,1,3-trimethyl-2,3-dihydro-1H-inden-4-yl]-1H-pyrazole-4-carboxamide, (B025 ) l-Methyl-3-(trifluoromethyl)-N-[2'-(trifluoromethyl)biphenyl-2-yl]-1H-pyrazole-4-carboxamide, (B026) 2-Fluoro-6-(trifluoromethyl)-N-(1,1,3-trimethyl-2,3-dihydro-1H-inden-4-yl)benzamide, (B027) 3 -(Difluoromethyl)-1-methyl-N-(1,1,3-trimethyl-2,3-dihydro-1H-inden-4-yl)-lHpyrazole-4-methan Amine, (B028) 3-(difluoromethyl)-1-methyl-N-[(3R)-1,1,3-trimethyl-2,3-dihydro-1H inden-4-yl] -lH-pyrazole-4-carboxamide (sulfluramid), (B029) 3-(difluoromethyl)-1-methyl-N-[(3S)-1,1,3-trimethyl -2,3-Dihydro-lH-inden-4-yl]-lH-pyrazole-4-carboxamide, (B030) 3-(difluoromethyl)-N-(7-fluoro-1,1 ,3-Trimethyl-2,3-dihydro-1H-inden-4-yl)-1-methyl-1H-pyrazole-4-carboxamide (fluinconazole), (B031) 3 -(Difluoromethyl)-N-[(3R)-7-fluoro-1,1,3-trimethyl-2,3-dihydro-1H-inden-4-yl]-1-methyl- 1H-pyrazole-4-carboxamide, (B032) 3-(difluoromethyl)-N-[(3S)-7-fluoro-1,1,3-trimethyl-2,3-dihydro -1H-inden-4-yl]-1-methyl-1H-pyrazole-4-carboxamide, (B033) 5,8-difluoro-N-[2-(2-fluoro-4-{[ 4-(Trifluoromethyl)pyridin-2-yl]oxy}phenyl)ethyl]quinazolin-4-amine, (B034) N-(2-cyclopentyl-5-fluorobenzyl)- N-cyclopropyl-3-(difluoromethyl)-5-fluoro-1-methyl-1H-pyrazole-4-carboxamide, (B035) N-(2-tert-butyl-5-methyl Benzyl)-N-cyclopropyl-3-(difluoromethyl)-5-fluoro-1-methyl-1Hpyrazole-4-carboxamide, (B036) N-(2-tert-butyl Benzyl)-N-cyclopropyl-3-(difluoromethyl)-5-fluoro-1-methyl-1H-pyrazole-4-carboxamide, (B037) N-(5-chloro-2 -Ethylbenzyl)-N-cyclopropyl-3-(difluoromethyl)-5-fluoro-1-methyl-1H-pyrazole-4-carboxamide, (B038) N-(5- Chloro-2-isopropylbenzyl)-N-cyclopropyl-3-(difluoromethyl)-5-fluoro-1-methyl-1H-pyrazole-4-carboxamide (isofluoroplan) , (B039) N-[(1R,4S)-9-(dichloromethylene)-1,2,3,4-tetrahydro-1,4-methylenenaphthalene-5-yl]-3-( Difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide, (B040) N-[(1S,4R)-9-(dichloromethylene)-1,2,3, 4-tetrahydro-1,4-methylene naphthalene-5-yl]-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide, (B041) N-[1 -(2,4-Difluorophenyl)-1-methoxypropan-2-yl]-3-(difluoromethyl)-1-methyl 1H-pyrazole-4-carboxamide, (B042 ) N-[2-Chloro-6-(trifluoromethyl)benzyl]-N-cyclopropyl-3-(difluoromethyl)-5-fluoro-1-methyl-1H-pyrazole-4 -Formamide, (B043 ) N-[3-Chloro-2-fluoro-6-(trifluoromethyl)benzyl]-N-cyclopropyl-3-(difluoromethyl)-5-fluoro-1-methyl-1H- Pyrazol-4-carboxamide, (B044)N-[5-chloro-2-(trifluoromethyl)benzyl]-N-cyclopropyl-3-(difluoromethyl)-5-fluoro- 1-Methyl-1H-pyrazole-4-carboxamide, (B045) N-cyclopropyl-3-(difluoromethyl)-5-fluoro-1-methyl-N-[5-methyl -2-(Trifluoromethyl)benzyl]-1H-pyrazole-4-carboxamide, (B046) N-cyclopropyl-3-(difluoromethyl)-5-fluoro-N-(2 -Fluoro-6-isopropylbenzyl)-1-methyl-1H-pyrazole-4-carboxamide, (B047) N-cyclopropyl-3-(difluoromethyl)-5-fluoro- N-(2-isopropyl-5-methylbenzyl)-1-methyl-1H pyrazole-4-carboxamide, (B048) N-cyclopropyl-3-(difluoromethyl)- 5-Fluoro-N-(2-isopropylbenzyl)-1-methyl-IH-pyrazole-4-thioamide, (B049) N-cyclopropyl-3-(difluoromethyl) -5-fluoro-N-(2-isopropylbenzyl)-1-methyl-1H-pyrazole-4-carboxamide, (B050) N-cyclopropyl-3-(difluoromethyl) -5-fluoro-N-(5-fluoro-2-isopropylbenzyl)-1-methyl-1H-pyrazole-4-carboxamide, (B051) N-cyclopropyl-3-(two Fluoromethyl)-N-(2-ethyl-4,5-dimethylbenzyl)-5-fluoro-1-methyl-1H-pyrazole-4-carboxamide, (B052) N-ring Propyl-3-(difluoromethyl)-N-(2-ethyl-5-fluorobenzyl)-5-fluoro-1-methyl-1H-pyrazole-4-carboxamide, (B053) N-Cyclopropyl-3-(difluoromethyl)-N-(2-ethyl-5-methylbenzyl)-5-fluoro-1-methyl-1H-pyrazole-4-carboxamide , (B054) N-cyclopropyl-N-(2-cyclopropyl-5-fluorobenzyl)-3-(difluoromethyl)-5-fluoro-1-methyl-1H-pyrazole-4 -Formamide, (B055) N-cyclopropyl-N-(2-cyclopropyl-5-methylbenzyl)-3-(difluoromethyl)-5-fluoro-1-methyl-1H -Pyrazole-4-carboxamide, (B056) N-cyclopropyl-N-(2-cyclopropylbenzyl)-3-(difluoromethyl)-5-fluoro-1-methyl-1H -Pyrazole-4-carboxamide, (B057) 2-(difluoromethyl)-N-(l,1-dimethyl-3-propyl-2,3-dihydro-1H-indene-4 -Base) Niacinamide, (B058) Pyrazolamide; (C) Respiratory chain complex III inhibitors, for example, (C001) pyraclostrobin, (C002) indazolamide, (C003) pyrazolam Strobilurin, (C004) methstrobin, (C005) syringostrobin, (C006) cyprofen, (C007) ketostrobin, (C00 8) Entrifloxystrobin, (C009) oxaconazole, (C010) pyraclostrobin, (C011) fluoxystrobin, (C012) fluoxastrobin, (C013) oxystrobin, (C014) phenoxy Strobil, (C015) orysastrobin, (C016) picoxystrobin, (C017) pyraclostrobin, (C018) pyraclostrobin, (C019) pyraclostrobin, (C020) trifloxystrobin, ( C021) (2E)-2-{2-[({[(1E)-1-(3-{[(E)-1-fluoro-2-phenylvinyl]oxy}phenyl)ethylene ]Amino}oxy)methyl]phenyl}-2-(methoxyimino)-N-methylacetamide, (C022) (2E,3Z)-5-{[1-(4-fluoro Phenyl)-lH-pyrazol-3-yl]oxy)-2-(methoxyimino)-N,3-dimethylpentyl-3-enamine, (C023) (2R)-2 -{2-[(2,5-Dimethylphenoxy)methyl]phenyl}-2-methoxy-N-methylacetamide, (C024) (2S)-2-{2- [(2,5-Dimethylphenoxy)methyl]phenyl}-2-methoxy-N-methylacetamide, (C025) (3S,6S,7R,8R)-8-benzyl Group-3-[({3-[(isobutyroxy)methoxy]-4-methoxypyridin-2-yl}carbonyl)amino]-6-methyl-4,9-dioxo- Methyl 1,5-dioxolane-7-yl-2-propionate (Benzoxamid), (C026) 2-{2-[(2,5-dimethylphenoxy)methyl] Phenyl}-2-methoxy-N-methylacetamide (Methoxyacrylate fungicide), (C027) N-(3-ethyl-3,5,5-trimethylcyclohexyl )-3-Formamide-2-hydroxybenzamide, (C028) (2E,3Z)-5-{[1-(4-chloro-2-fluorophenyl)-lH-pyrazole-3- Yl]oxy}-2-(methoxyimino)-N,3-dimethylpentyl-3-enamine, (C029) methyl{5-[3-(2,4-dimethyl Phenyl)-lH-pyrazol-1-yl]-2-methylbenzyl}carbamate, (C030) 1-(2-{[1-(4-fluorophenyl)pyrazole-3- Yl]oxymethyl}-3-methylphenyl)-1,4-dihydro-4-methyl-5H-tetrazol-5-one (benylpyrazole), (C031) pyridine amides Fungicides; (D) mitosis and cell division inhibitors, for example, (D001) carbendazim, (D002) dimethocarb, (D003) ethaboxam, (D004) fluopyram, (D005) pentostam , (D006) Thiabendazole, (D007) Thiophanate-methyl, (D008) Bentostam, (D009) 3-chloro-4-(2,6-difluorophenyl)-6-methyl- 5-Phenylpyridazine, (D010) 3-chloro-5-(4-fluorophenyl) -4-(2,6-Difluorophenyl)-6-methylpyridazine, (D011) 3-chloro-5-(6-chloropyridin-3-yl)-6-methyl-4-(2 ,4,6-Trifluorophenyl)pyridazine, (D012) 4-(2-bromo-4-fluorophenyl)-N-(2,6-difluorophenyl)-l,3-dimethyl -1H-pyrazole-5-amine, (D013) 4-(2-bromo-4-fluorophenyl)-N-(2-bromo-6-fluorophenyl)-l,3-dimethyl-1H -Pyrazol-5-amine, (D014) 4-(2-bromo-4-fluorophenyl)-N-(2-bromophenyl)-1,3-dimethyl-lH-pyrazole-5- Amine, (D015) 4-(2-bromo-4-fluorophenyl)-N-(2-chloro-6-fluorophenyl)-1,3-dimethyl-1H-pyrazol-5-amine, (D016) 4-(2-Bromo-4-fluorophenyl)-N-(2-fluorophenyl)-1,3-dimethyl-1H-pyrazol-5-amine, (D017)4-( 2-Bromo-4-fluorophenyl)-N-(2-fluorophenyl)-1,3-dimethyl-1H-pyrazol-5-amine, (D018) 4-(2-chloro-4- Fluorophenyl)-N-(2,6-Difluorophenyl)-l,3-dimethyl-1H-pyrazol-5-amine, (D019) 4-(2-chloro-4-fluorophenyl) )-N-(2-chloro-6-fluorophenyl)-1,3-dimethyl-1H-pyrazol-5-amine, (D020) 4-(2-chloro-4-fluorophenyl)- N-(2-fluorophenyl)-l,3-dimethyl-1H-pyrazol-5-amine, (D021) 4-(2-chloro-4-fluorophenyl)-N-(2-fluoro Phenyl)-1,3-dimethyl-1H-pyrazol-5-amine, (D022) 4-(4-fluorophenyl)-5-(2,6-difluorophenyl)-3,6 -Dimethylpyridazine, (D023) N-(2-bromo-6-fluorophenyl)-4-(2-chloro-4-fluorophenyl)-1,3-dimethyl-1H-pyrazole -5-amine, (D024) N-(2-bromophenyl)-4-(2-chloro-4-fluorophenyl)-1,3-dimethyl-1H-pyrazol-5-amine, ( D025) N-(4-chloro-2,6-difluorophenyl)-4-(2-chloro-4-fluorophenyl)-1,3-dimethyl-1H-pyrazol-5-amine; (E) Compounds with multiple actions, for example, (E001) Bordeaux mixture, (E002) Dicaptan, (E003) Captan, (E004) Chlorothalonil, (E005) Copper hydroxide, (E006) Ring Copper alkanoate, (E007) copper oxide, (E008) copper oxychloride, (E009) copper sulphate (2+), (E010) dithianon, (E011) doridine, (E012) sanitizer, (E013) Mancozeb, (E014) Mancozeb, (E015) Mancozeb, (E016) Mancozeb, (E017) Copper quinoline, (E018) Zinc methyl, (E019) sulfur and sulfur preparations, including calcium polysulfide, (E020) thiram, (E021) thiram, (E022) thiram, (E023) 6-ethyl-5,7- Dioxo-6,7-dihydro-5Hpyrrolo[3',4':5,6][1,4]dithianon[2,3-c][1,2]thiazole-3-carbonitrile; (F) Compounds capable of inducing host defenses, such as (F001) benzothiadiazole, (F002) isotianil, (F003) thiabendazole, (F004) tithiazamide; (G) amino acids and/or Protein biosynthesis inhibitors, such as (G001) cyprodinil, (G002) kasugamycin, (G003) kasugamycin hydrochloride, (G004) oxytetracycline, (G005) pyrimethanil, (G006) 3 -(5-Fluoro-3,3,4,4-tetramethyl-3,4-dihydroisoquinolin-1-yl)quinoline; (H) ATP production inhibitor, such as (H001) thiosilica Amines; (I) Cell wall synthesis inhibitors, such as (I001) Benthiasamide, (I002) Dimorpholine, (I003) Flumorph, (I004) Prosoprol, (I005) Dipropanil , (I006) Pyrmorpholine, (I007) Valinyl, (I008) (2E)-3-(4-tert-butylphenyl)-3-(2-chloropyridin-4-yl)-l-( Morpholin-4-yl)propyl-2-en-1-one, (I009) (2Z)-3-(4-tert-butylphenyl)-3-(2-chloropyridin-4-yl)- 1-(morpholin-4-yl)propyl-2-en-1-one; (J) lipid and membrane synthesis inhibitors, such as (J001) propamocarb, (J002) propamocarb hydrochloride, ( J003) Tolclofos methyl; (K) melanin biosynthesis inhibitors, such as (K001) tricyclazole, (K002) 2,2,2-trifluoroethyl {3-methyl-1-[(4- (Methylbenzyl)amino]butan-2-yl}carbamate; (L) nucleic acid synthesis inhibitors, such as (L001) benaxyl, (L002) benaxyl-M (jing benaxyl) ), (L003) Metalaxyl, (L004) Metalaxyl-M (Metalaxyl); (M) Signal transduction inhibitors, such as (M001) Fludioxonil, (M002) Iprodione, (M003) ) Procymidone, (M004) Propoxyquin, (M005) Quinoxaline, (M006) Vinclozolin; (N) Compounds that can be used as decoupling agents, such as (N001) Fluazinam, (N002 ) Many mites are eliminated; (O) Other compounds, such as (O001) abscisic acid, (O002) thiocyanate, (O003) benzoxazine, (O004) carbamazecin, (O005) Carvone, (O006) Acaricide, (O007) Thiazol, (O008) Cyfluxan, (O009) Cymoxanil, (O010) Cyprosulfonamide, (O011) Flutidine Ni, (O012) aluminum triethylphosphonate, (O013) calcium triethylphosphonate, (O014) sodium, (O015) methyl isothiocyanate, (O016) benzophenone, (O017) mitomycin , (O018) Natamycin, (O019) Nickel Phosphate, (O020) Phthalostrobin, (O021) Oxacarb, (O022) Fluthiazol pyretidone, (O023) Oxyphenthiol, (O024) Five Chlorophenol and its salts, (O025) phosphoric acid and its salts, (O026) propamocarb phosphonate, (O027) benzodiazepine (chlorazone), (O028) isobutyl ethoxyquin, ( O029) Leaf cumin, (O030) Messulfan, (O031) 1-(4-{4-[(5R)-5-(2,6-Difluorophenyl)-4,5-dihydro- 1,2-oxazol-3-yl]-1,3-thiazol-2-yl}piridin-1-yl)-2-[5-methyl-3-(trifluoromethyl)-1H-pyridine Azol-1-yl] ethyl ketone, (O032) 1-(4-{4-[(5S)-5-(2,6-difluorophenyl)-4,5-dihydro-l ,2-oxa Azol-3-yl]-l,3-thiazol-2-yl}piridin-1-yl)-2-[5-methyl-3-(trifluoromethyl)-lH-pyrazol-1-yl ] Ethyl ketone, (O033) 2-(6-benzylpyridin-2-yl)quinazoline, (O034) 2,6-dimethyl-1H,5H-[1,4]dithianon[2, 3-c:5,6-c']dipyrrole-1,3,5,7(2H,6H)-tetraketone, (O035) 2-[3,5-bis(difluoromethyl)-lH- Pyrazol-1-yl]-1-[4-(4-{5-[2-(propyl-2-yn-1-yloxy)phenyl]-4,5-dihydro-1,2 -Oxazol-3-yl}-l,3-thiazol-2-yl)piridin-1-yl]ethanone, (O036) 2-[3,5-bis(difluoromethyl)-1H-pyridine Azol-1-yl]-1-[4-(4-{5-[2-chloro-6-(propyl-2-yn-1-yloxy)phenyl]-4,5-dihydro- 1,2-oxazol-3-yl}-1,3-thiazol-2-yl)piridin-1-yl]ethanone, (O037) 2-[3,5-bis(difluoromethyl)- lH-Pyrazol-1-yl]-1-[4-(4-{5-[2-Fluoro-6-(propyl-2-yn-1-yloxy)phenyl]-4,5- Dihydro-l,2-oxazol-3-yl}-l,3-thiazol-2-yl)piridin-1-yl]ethanone, (O038) 2-[6-(3-fluoro-4- Methoxyphenyl)-5-methylpyridin-2-yl]quinazoline, (O039) 2-{(5R)-3-[ 2-(1-{[3,5-Bis(difluoromethyl)-lH-pyrazol-1-yl]acetyl}piridin-4-yl)-1,3-thiazol-4-yl] -4,5-Dihydro-l,2-oxazol-5-yl}-3-fluorophenyl methanesulfonate, (O040) 2-{(5S)-3-[2-(1-{[ 3,5-Bis(difluoromethyl)-1H-pyrazol-1-yl]acetin-4-yl)-1,3-thiazol-4-yl)-4,5-dihydro -1,2-oxazol-5-yl}-3-fluorophenyl methanesulfonate, (O041) 2-{2-[(7,8-difluoro-2-methylquinolin-3-yl )Oxy]-6-fluorophenyl}propan-2-ol, (O042) 2-{2-fluoro-6-[(8-fluoro-2-methylquinolin-3-yl)oxy]benzene Yl}propan-2-ol, (O043) 2-{3-[2-(1-{[3,5-bis(difluoromethyl)-1H-pyrazol-1-yl]acetyl}呱(Pyridin-4-yl)-1,3-thiazol-4-yl]-4,5-dihydro-1,2-oxazol-5-yl)-3-fluorophenyl methanesulfonate (Bayer "Wonderful "Fungicide), (O044)2-{3-[2-(1-{[3,5-bis(difluoromethyl)-1H-pyrazol-1-yl]acetinyl}piperidine-4 -Yl)-1,3-thiazol-4-yl]-4,5-dihydro-1,2-oxazol-5-yl}phenyl methanesulfonate, (O045) 2-phenylphenol and salt , (O046) 3-(4,4,5-trifluoro-3,3-dimethyl-3,4-dihydroisoquinolin-1-yl)quinoline, (O047) 3-(4,4 -Difluoro-3,3-dimethyl-3,4-dihydroisoquinolin-1-yl)quinoline (quinoline fungicide), (O048) 4-amino-5-fluoropyrimidine-2- Alcohol (tautomer: 4-amino-5-fluoropyrimidine-2(1H)-one), (O049) 4-oxo-4-[(2-phenylethyl)amino]butyric acid, (O050 ) 5-Amino-1,3,4-thiadiazole-2-thiol, (O051) 5-chloro-N'-phenyl-N'-(propyl-2-yn-1-yl)thiophene- 2-sulfonamide, (O052) 5-fluoro-2-[(4-fluorobenzyl)oxy]pyrimidin-4-amine, (O053) 5-fluoro-2-[(4-methylbenzyl) Oxy)pyrimidin-4-amine, (O054) 9-fluoro-2,2-dimethyl-5-(quinolin-3-yl)-2,3-dihydro-1,4-phenoxazapine , (O055) But-3-yn-1-yl{6-[({[(Z)-(l-methyl-1H-tetrazol-5-yl)(phenyl)methylene]amino}oxy Yl)methyl]pyridin-2-yl}carbamate, (O056) ethyl (2Z)-3-amino-2-cyano-3-phenyl acrylate, (O057) phenazine-1-carboxylic acid , (O058) propyl 3,4,5-trihydroxybenzyl, (O059) quinoline-8-ol, (O060 ) Quinoline-8-ol sulfate (2:1), (O061) tert-butyl {6-[({[(1-methyl-1H-tetrazol-5-yl)(phenyl)methylene ]Amino}oxy)methyl]pyridin-2-yl}carbamate, (O062) 5-fluoro-4-imino-3-methyl-1-[(4-methylphenyl)sulfonamide Base]-3,4-dihydropyrimidine-2(1H)-one, (O063) pyridine chloromethyl, (O064) isoflurane, (O065) a broad-spectrum pyridine fungicide. (P) Histone deacetylase inhibitors, such as (P001) N-(1-ethylcyclopropyl)-4-[5-(trifluoromethyl)-1,2,4-oxadiazole -3-yl]benzamide; (P002) N-(2-isopropylcyclopropyl)-4-[5-(trifluoromethyl)-1,2,4-oxadiazole-3- Base] benzamide; (P003) N-(2-methylcyclopropyl)-4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]benzyl Amide; (P004) N-(1-methylcyclopropyl)-4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]benzamide; ( P005) N-(2-Ethylcyclopropyl)-4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]benzamide; (P006) N- (2,4-Difluorophenyl)-4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]benzamide; (P007) 5-(trifluoro Methyl)-3-[4-[[3-(trifluoromethyl)-1,2,4triazol-1-yl]methyl]phenyl]-1,2,4-oxadiazole; (P008) 2-[[4-[5-(Trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]-1,2,4-triazole-3-carbonitrile; (P009) Ethyl 1-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl)pyrazole-4-carboxylate; (P010) N-cyclopropyl-1-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)phenyl)methyl)pyrazole-4- Formamide; (P011) N,N-dimethyl-1-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl ]Pyrazole-4-carboxamide; (P012) N-methyl-1-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl ]Methyl]pyrazole-4-carboxamide; (P013) N,N,-dimethyl-H[4-[5-(trifluoromethyl)-1,2,4-oxadiazole-3 -Yl]phenyl]methyl]-1,2,4-triazole-3-amine; (P014) 3-[4-[(5-ethylsulfonyl-1,2,4-triazole- 1-yl)methyl]phenyl)-5-(trifluoromethyl)-1,2,4-oxadiazole; (P015) 3-[4-(triazole[4,5-b]pyridine- 1-ylmethyl)phenyl]-5-(trifluoromethyl)-1,2,4-oxadiazole; (P016) 3-[4-(triazole[4,5-b]pyridine-2 -Ylmethyl)phenyl]-5-(trifluoromethyl)-1,2,4-oxadiazole; (P017) 3-[4-(triazole[4,5-b]pyridine-3- (Phenylmethyl)phenyl]-5-(trifluoromethyl)-1,2,4-oxadiazole; (P018) methyl 1-[[4-[5-(trifluoromethyl)-1, 2,4-oxadiazole-3- Yl]phenyl]methyl]pyrazole-4-carboxylate; (P019) 1-[[3-fluoro-4-[5-(trifluoromethyl)-1 ,2,4-oxadiazole- 3-yl]phenyl]methyl]pyrazole-4-carboxylic acid ethyl ester; (P020) N,N -diethyl-1-[[4-[5-(trifluoromethyl)-1,2 ,4-oxadiazol-3-yl]phenyl]methyl]pyrazole-4-carboxamide; (P021) N -methoxy- N -methyl-1-[[4-[5-( Trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]pyrazole-4-carboxamide; (P022) propyl 1-[[4-[5-( Trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]pyrazole-4-carboxylate; (P023) N -methoxy-1-[[4- [5-(Trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]pyrazole-4-carboxamide; (P024) N -ethyl-1-[ [4-[5-(Trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]pyrazole-4-carboxamide; (P025) 1-[[4 -[5-(Trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]pyrazole-4-carboxamide; (P026) N -methoxy-1 -[1-[[4-[5-(Trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]pyrazol-4-yl]imine; (P027 ) Ethyl 1-[1-[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]ethyl]pyrazole-4-carboxylate; (P028) 1-[[4-[5-(Trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]pyrrolidin-2-one; (P029) 1 -[[4-[5-(Trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]piridin-2-one; (P030) 4-[[4 -[5-(Trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]morpholin-3-one; (P031) 4,4-dimethyl-2 -[[4-[5-(Trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]isoxazolin-3-one; (P032) 2-[ [4-[5-(Trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]isoxazolin-3-one; (P033) 5,5-di Methyl-2-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]isoxazolin-3-one; (P034 ) 3,3-Dimethyl-1 [4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]piridin-2-one; (P035) 1-[[2-Fluoro-4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]pyrrolidin-2-one; (P036) 1-((2-Fluoro-4-(5-(三Fluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]piridin-2-one; (P037) 2-[[4-[5-(trifluoromethyl) -1,2,4-oxadiazol-3-yl]phenyl]methyl]oxazin-3-one; (P038) 1-[[3-fluoro-4-[5-(trifluoromethyl) -1,2,4-oxadiazol-3-yl]phenyl]methyl]piridin-2-one; (P039) 3-[[4-[5-(trifluoromethyl)-1,2 ,4-oxadiazol-3-yl]phenyl]methyl]oxazolidine-2-one; (P040) 1-methyl-3-[[4-[5-(trifluoromethyl)-1, 2,4-oxadiazol-3-yl]phenyl]methyl]imidazolin-2-one; (P041) 1-[[3-fluoro-4-[5-(trifluoromethyl)-1 ,2,4-oxadiazol-3-yl]phenyl]methyl]-3,3-dimethyl-pyridin-2-one; (P042) 1-[[3-fluoro-4-[5 -(Trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]pyrrolidin-2-one; (P043) 2-[[3-fluoro-4-[5 -(Trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]-4,4-dimethyl-isoxazolin-3-one; (P044) 2 -[[2,3-Difluoro-4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]isoxazolin-3-one ;(P045) 2-[[3-Fluoro-4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]isoxazoline-3 -Ketone; (P046) 1-[[3-Fluoro-4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]azidine- 2-ketone; (P047) N-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]propanamide; (P048) 2,2-Dimethyl-N-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]butyl-3-yne Amide; (P049) N-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]butyramide; (P050) 3 -Methyl-N-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]butyramide; (P051) 2-methyl Group-N-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]propyl-2-enamine; (P052) 2 -Methyl-N-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]butyramide; (P053) 2-methyl Oxy-N-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]; (P054) 3,3,3-tri Fluoro-N-[[3-Fluoro-4-[5-(trifluoromethyl)-1,2, 4-oxadiazol-3-yl]phenyl]methyl]propanamide; (P055) 3,3,3-trifluoro-N-[[2-fluoro-4-[5-(trifluoromethyl )-1,2,4-oxadiazol-3-yl]phenyl]methyl]propanamide; (P056) N-[[2,3-difluoro-4-[5-(trifluoromethyl )-1,2,4-oxadiazol-3-yl]phenyl]methyl]butyramide; (P057) N-[[2,3-difluoro-4-[5-(trifluoromethyl )-1,2,4-oxadiazol-3-yl]phenyl]methyl]-3,3,3-trifluoro-propionamide; (P058) 2-(difluoromethoxy)-N -[[4-[5-(Trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]acetamide; (P059) 2-methoxy-2- Methyl-N-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]propanamide; (P060) 1-methyl -3-[[4-[5-(Trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]urea; (P061) 1-ethyl-1-methyl Base-3-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]urea; (P062) 1-ethoxy-3 -[[4-[5-(Trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]urea; (P063) 1-methoxy-1-methyl -3-[[4-[5-(Trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]; (P064) 1,1-diethyl-3 -[[4-[5-(Trifluoromethyl)-1 ,2,4-oxadiazol-3-yl]phenyl]methyl]urea; (P065) N-methoxy-N-[[ 4-[5-(Trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]cyclopropanecarboxamide; (P066) N-methoxy-N-[ [4-[5-(Trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]pentyl-4-ynamide; (P067) N-methoxy -2-Methyl-N-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]propyl-2-enamine; (P068) N,2-Dimethoxy-N-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)phenyl)methyl)propane Amine; (P069) N-cyclopropyl-3,3,3-trifluoro-N-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl] Phenyl]methyl]propanamide; (P070) 2,2-difluoro-N-(2-methoxyethyl)-N-[[4-[5-(trifluoromethyl)-1, 2,4-oxadiazol-3-yl]phenyl]methyl]cyclopropanecarboxamide; (P071) N-ethyl-2-methyl-N-[[4-[5-(trifluoromethyl Yl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]propanamide; ( P072) N-[[3-Fluoro-4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl)-N-methoxy-propyl Amide; (P073) 2-methoxy-N-(2,2,2-trifluoroethyl)-N-[[4-[5-(trifluoromethyl)-1,2,4-oxa Diazol-3-yl]phenyl]methyl]acetamide; (P074) N-[[2,3-difluoro-4-[5-(trifluoromethyl)-1,2,4-oxa Diazol-3-yl]phenyl]methyl]-N-methoxy-cyclopropanecarboxamide; (P075) 2-(difluoromethoxy)-N-methyl-N-[[4- [5-(Trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]acetamide; (P076) N-ethoxy-2-methoxy-N -[[4-[5-(Trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]propanamide; (P077) N-isopropyl-N- [[4-[5-(Trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]tetrahydrofuran-2-carboxamide; (P078) 1-methoxy -3-Methyl-1-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]urea; (P079) 3-ring Propyl-1-methoxy-1-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]urea; (P080) 3-ethoxy-1-methoxy-1-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]urea; (P081) 3-allyl-1-methoxy-1-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl)methyl ] Urea; (P082) 1-cyclopropyl-3-methoxy-3-methyl-1-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazole-3 -Yl]phenyl]methyl]urea; (P083) 3-isopropyl-1-methoxy-1-[[4-[5-(trifluoromethyl)-1,2,4-oxa Azol-3-yl]phenyl]methyl]urea; (P084) 1-methoxy-3-propyl-2-ynyl-1-[[4-[5-(trifluoromethyl)-1 ,2,4-oxadiazol-3-yl]phenyl]methyl]urea; (P085) 1-[[3-fluoro-4-[5-(trifluoromethyl)-1,2,4- Oxadiazol-3-yl]phenyl]methyl]-1-methoxy-3-methyl-urea; (P086) 3-(cyclopropylmethyl)-1-methyl-1-[[ 4-[5-(Trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]urea; (P087) 1-ethyl-3-(2,2,2 -Trifluoroethyl)-1-[[4-[5-(Trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]urea; (P088) 1, 3-Dimethoxy-1-[[4-[5-(trifluoromethyl)-1,2 ,4-oxadiazol-3-yl]phenyl]methyl]urea; (P089) 3-ethyl-1-methoxy-1-[[4-[5-(trifluoromethyl)-1 ,2,4-oxadiazol-3-yl]phenyl]methyl]urea; (P090) N-methyl-4-[5-(trifluoromethyl)-1,2,4-oxadiazole -3-yl]benzamide; (P091) N-[(E)-methoxyiminomethyl]-4-[5-(trifluoromethyl)-1,2,4-oxadiazole -3-yl]benzamide; (P092) N-[(Z)-methoxyiminomethyl]-4-[5-(trifluoromethyl)-1,2,4-oxadiazole -3-yl]benzamide; (P093) N-[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]cyclopropanecarboxamide ; (P094) N-(2-fluorophenyl)-4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]benzamide; (P095) 2, 2-Difluoro-N-methyl-2-[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]acetamide; (P096) N -Allyl-N-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]acetamide; (P097) N- [(E)-N-Methoxy-C-methyl-carbimino]-4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]benzoyl Amine; (P098) N-[(Z)-N-methoxy-C-methyl-carbimino]-4-[5-(trifluoromethyl)-1,2,4-oxadiazole- 3-yl]benzamide; (P100) N-allyl-N-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl ]Methyl]propanamide; (P101) 4,4-dimethyl-1-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]benzene Yl]methyl]pyrrolidin-2-one; (P102) N-methyl-4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]benzylthiol Amine; (P103) 5-methyl-1-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]pyrrolidine-2 -Ketone; (P104) N-methyl-4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]benzamide; (P105) N1-methyl -N2-(4-(5-(Trifluoromethyl)-1,2,4-oxadiazol-3-yl)benzyl) glufamide.
如果官能團允許，所有列出的（A）至（P）類的混合夥伴都可以選擇與合適的鹼或酸形成鹽。If the functional group permits, all the listed mixing partners (A) to (P) can be selected to form salts with suitable bases or acids.
能用作安全劑的其他化合物，例如雜環羧酸衍生物類化合物，例如二氟苯基吡唑啉-3-羧酸類化合物，優選化合物(Q001) 1-(2,4-二氟苯基)-5-(乙氧基羰基)-5-甲基-2-吡唑啉-3-羧酸，(Q002) 乙基1-(2,4-二氟苯基)-5-(乙氧基羰基)-5-甲基-2-吡唑啉-3-羧酸鹽("吡唑解草酯(-二乙基)")等化合物，以及WO199107874中所述的相關化合物。Other compounds that can be used as safeners, such as heterocyclic carboxylic acid derivatives, such as difluorophenylpyrazoline-3-carboxylic acid compounds, preferably compound (Q001) 1-(2,4-difluorophenyl) )-5-(ethoxycarbonyl)-5-methyl-2-pyrazoline-3-carboxylic acid, (Q002) ethyl 1-(2,4-difluorophenyl)-5-(ethoxy Carbonyl)-5-methyl-2-pyrazoline-3-carboxylate ("pyrazolofen (-diethyl)") and other compounds, and related compounds described in WO199107874.
當化合物(1)或化合物(2)可以以互變異構體的形式出現時，即使這些形式在每種情況下並沒有特別提到，上述和下文所述的化合物在適用的情況下也被理解為包括相應的互變異構體形式。When compound (1) or compound (2) may appear in the form of tautomers, even if these forms are not specifically mentioned in each case, the compounds described above and below are understood where applicable To include the corresponding tautomeric forms.
這裡所指定的活性成分的通用名稱是已知的，例如在《農藥手冊》（第16版.英國農作物保護委員會）中有介紹，或者可以在互聯網中（例如www.alanwood.net/pesticides）進行搜索。The generic names of the active ingredients specified here are known, for example in the "Pesticide Handbook" (16th edition. British Crop Protection Commission), or can be done on the Internet (eg www.alanwood.net/pesticides) search.
本發明的化合物(I)的特別優選的組合物包含至少一種下列活性化合物（2）： (A) 麥角固醇生物合成抑制劑，例如，(A001) 環丙唑醇，(A002) 苯醚甲環唑，(A003) 氟環唑，(A004) 環醯菌胺，(A005) 苯鏽啶，(A006) 丁苯嗎啉，(A007) 胺苯吡菌酮，(A008) 氟喹唑，(A009) 粉唑醇，(A010) 抑黴唑，(A011) 硫酸抑黴唑，(A012) 種菌唑，(A013) 葉菌唑，(A014) 腈菌唑，(A015) 多效唑，(A016) 咪鮮胺，(A017) 丙環唑，(A018) 丙硫菌唑，(A019) 啶菌唑，(A020) 螺環菌胺，(A021) 戊唑醇，(A022) 氟醚唑，(A023) 三唑醇，(A024) 十三嗎啉，(A025) 滅菌唑，(A026) (1R,2S,5S)-5-(4-氯苄基)-2-(氯甲基)-2-甲基-l-(lH-1,2,4-三唑-l基甲基)環戊醇，(A027) (1S,2R,5R)-5-(4-氯苄基)-2-(氯甲基)-2-甲基-1-(1H-1,2,4-三唑-l-基甲基)環戊醇, (A028) (2R)-2-(l-氯環丙基)-4-[(1R)-2,2-二氯環丙基]-l-(lH-1,2,4-三唑-l-基)丁烷-2-醇，(A029) (2R)-2-(l-氯環丙基)-4-[(lS)-2,2-二氯環丙基]-1-(lH-1,2,4-三唑-1-基)丁烷-2-醇，(A030) (2R)-2-[4-(4-氯苯氧基)-2-(三氟甲基)苯基]-1-(1H-1,2,4-三唑-1-基)丙烷-2-醇，(A031) (2S)-2-(1-氯環丙基)-4-[(1R)-2,2-二氯環丙基]-1-(1H-l,2,4-三唑-1-基)丁烷-2-醇, (A032) (2S)-2-(1-氯環丙基)-4-[(1S)-2,2-二氯環丙基]-1-(1H-1,2,4-三唑-1-基)丁烷-2-醇，(A033) (2S)-2-[4-(4-氯苯氧基)-2-(三氟甲基)苯基]-1-(lH-1,2,4-三唑-1-基)丙烷-2-醇，(A034) (R)-[3-(4-氯-2-氟苯基)-5-(2,4-二氟苯基)-1,2-惡唑-4-基](吡啶-3-基)甲醇，(A035) (S)[3-(4-氯-2-氟苯基)-5-(2,4-二氟苯基)-l,2-惡唑-4-基](吡啶-3-基)甲醇，(A036) [3- (4-氯-2-氟苯基)-5-(2,4-二氟苯基)-1,2-惡唑-4-基](吡啶-3-基)甲醇，(A037) 1-({(2R,4S)-2-[2-氯-4-(4-氯苯氧基)苯基]-4-甲基-1,3-二氧戊環-2-基}甲基)-1H-1,2,4-三唑，(A038) 1-({(2S,4S)-2-[2-氯-4-(4-氯苯氧基)苯基]-4-甲基-l,3-二氧戊環-2-基}甲基)-lH-1,2,4-三唑，(A039)1-{[3-(2-氟苯基)-2-(2,4-二氟苯基)氧化乙烯-2-基]甲基}-lH-1,2,4-三唑-5-基 硫氰酸鹽，(A040) l-{[rel(2R,3R)-3-(2-氟苯基)-2-(2,4-二氟苯基)氧化乙烯-2-基]甲基}-1H-1,2,4-三唑-5-基 硫氰酸鹽，(A041) l-{[rel(2R,3S)-3-(2- 氟苯基)-2-(2,4-二氟苯基)氧化乙烯-2-基]甲基}-1H-1,2,4-三唑-5-基 硫氰酸鹽，(A042) 2-[(2R,4R,5R)-1-(2,4-二氟苯基)-5-羥基-2,6,6-三甲基庚烷-4-基]-2,4-二氫-3H-1,2,4-三唑-3-硫酮，(A043) 2-[(2R,4R,5S)-1-(2,4-二氟苯基)-5-羥基-2,6,6-三甲基庚烷-4-基]-2,4-二氫-3H-1,2,4-三唑-3-硫酮，(A044) 2-[(2R,4S,5R)-l-(2,4-二氟苯基)-5-羥基-2,6,6-三甲基庚烷-4-基]-2,4-二氫-3H-1,2,4-三唑-3-硫酮，(A045) 2-[(2R,4S,5S)-l-(2,4-二氟苯基)-5-羥基-2,6,6-三甲基庚烷-4-基]-2,4-二氫-3H-1,2,4-三唑-3-硫酮，(A046)2-[(2S,4R,5R)-1-(2,4-二氟苯基)-5-羥基-2,6,6-三甲基庚烷-4-基]-2,4-二氫-3H-1,2,4-三唑-3-硫酮，(A047) 2-[(2S,4R,5S)-1-(2,4-二氟苯基)-5-羥基-2,6,6-三甲基庚烷-4-基]-2,4-二氫-3H-1,2,4-三唑-3-硫酮，(A048) 2-[(2S,4S,5R)-1-(2,4-二氟苯基)-5-羥基-2,6,6-三甲基庚烷-4-基]-2,4-二氫-3H-1,2,4-三唑-3-硫酮，(A049) 2-[(2S,4S,5S)-l-(2,4-二氟苯基)-5-羥基-2,6,6-三甲基庚烷-4-基]-2,4-二氫-3H-1,2,4-三唑-3-硫酮，(A050) 2-[1-(2,4-二氟苯基)-5-羥基-2,6,6-三甲基庚烷-4-基]-2,4-二氫-3H-1,2,4-三唑-3-硫酮，(A051)2-[2-氯-4-(2,4-二氯苯氧基)苯基]-l-(1H-1,2,4-三唑-1-基)丙烷-2-醇，(A052) 2-[2-氯-4-(4-氯苯氧基)苯基]-1-(lH-1,2,4-三唑-1-基)丁烷-2-醇，(A053) 2-[4-(4-氯苯氧基)-2-(三氟甲基)苯基]-1-(lH-1,2,4-三唑-1-基)丁烷-2-醇，(A054) 2-[4-(4-氯苯氧基)-2-(三氟甲基)苯基]-1-(1H-1,2,4-三唑-l -基)戊烷-2-醇，(A055) 2-[4-(4-氯苯氧基)-2-(三氟甲基)苯基]-1-(lH-1,2,4-三唑-1-基)丙烷-2-醇，(A056) 2-{[3-(2-氟苯基)-2-(2,4-二氟苯基)氧化乙烯-2-基]甲基}-2,4-二氫-3H-l,2,4-三唑-3-硫酮，(A057) 2-{[rel(2R,3R)-3-(2-氟苯基)-2-(2,4-二氟苯基)氧化乙烯-2-基]甲基}-2,4-二氫-3H-1,2,4-三唑-3-硫酮，(A058) 2-{[rel(2R,3S)-3-(2-氟苯基)-2-(2,4-二氟苯基)氧化乙烯-2- 基]甲基}-2,4-二氫-3H-l,2,4-三唑-3-硫酮，(A059) 5-(4-氯苄基)-2-(氯甲基)-2-甲基-1-(lH-1,2,4-三唑-1-基甲基)環戊醇，(A060) 5-(烯丙基磺醯基)-1-{[3-(2-氟苯基)-2-(2,4-二氟苯基)氧化乙烯-2-基]甲基}-1H-1,2,4-三唑，(A061) 5-(烯丙基磺醯基)-1-{[rel(2R,3R)-3-2-氟苯基)-2-(2,4-二氟苯基)氧化乙烯-2-基]甲基}-1H-1,2,4-三唑，(A062) 5-(烯丙基磺醯基)-1-{[rel(2R,3S)-3-(2-氟苯基)-2-(2,4-二氟苯基)氧化乙烯-2-基]甲基}-1H-1,2,4-三唑，(A063) N'-(2,5-二甲基-4-{[3-(1,1,2,2-四氟乙氧基)苯基]磺醯基}苯基)-N-乙基-N甲基亞氨基甲醯胺，(A064) N'-(2,5-二甲基-4-{[3-(2,2,2-三氟乙氧基)苯基]磺醯基}苯基)N-乙基-N-甲基亞氨基甲醯胺，(A065) N'-(2,5-二甲基-4-{[3-(2,2,3,3-四氟丙氧基)苯基]磺醯基}苯基)-N-乙基-N-甲基亞氨基甲醯胺，(A066) N'-(2,5-二甲基-4-{[3-(五氟乙氧基)苯基]磺醯基}苯基)-N-乙基-N-甲基亞氨基甲醯胺，(A067) N'-(2,5-二甲基-4-{3-[(1,l,2,2-四氟乙基)磺醯基]苯氧基}苯基)-N-乙基-N甲基亞氨基甲醯胺，(A068) N'-(2,5-二甲基-4-{3-[(2,2,2-三氟乙基)磺醯基]苯氧基}苯基)N-乙基-N-甲基亞氨基甲醯胺，(A069) N'-(2,5-二甲基-4-{3-[(2,2,3,3-四氟丙基)磺醯基]苯氧基}苯基)-N-乙基-N-甲基亞氨基甲醯胺，(A070) N'-(2,5-二甲基-4-{3-[(五氟乙基)磺醯基]苯氧基}苯基)-N-乙基-N-甲基亞氨基甲醯胺，(A071) N'-(2,5-二甲基-4-苯氧基苯基)-N-乙基-N-甲基亞氨基甲醯胺，(A072) N'-(4-{[3-(二氟甲氧基)苯基]磺醯基}-2,5-二甲基苯基)-N-乙基-N-甲基亞氨基甲醯胺，(A073) N'(4-{3-[(二氟甲基)磺醯基]苯氧基}-2,5-二甲基苯基)-N-乙基-N-甲基亞氨基甲醯胺，(A074) N'-[5-溴-6-(2,3-二氫-lH-茚-2-基氧基)-2-甲基吡啶-3-基]-N-乙基-N甲基亞氨基甲醯胺，(A075) N'-{4-[(4,5-二氯-1,3-噻唑-2-基)氧基]-2,5-二甲基苯基}-N乙基-N-甲基亞氨基甲醯胺，(A076) N'-{5-溴-6-[(1R)-1-(3,5-二氟苯基)乙氧基]-2-甲基吡啶-3-基}-N-乙基-N-甲基亞氨基甲醯胺，(A077)N'-{5-溴-6-[(1S)-1-(3,5-二氟苯基)乙氧基]-2-甲基吡啶-3-基}-N-乙基-N-甲基亞氨基甲醯胺，(A078) N'-{5-溴-6-[(順式-4-異丙基環己基)氧基]-2-甲基吡啶-3-基}-N-乙基-N-甲基亞氨基甲醯胺，(A079) N'-{5-溴-6-[(反式-4-異丙基環己基)氧基]-2-甲基吡啶-3-基}-N-乙基-N甲基亞氨基甲醯胺，(A080) N'-{5-溴-6-[1-(3,5-二氟苯基)乙氧基]-2-甲基吡啶-3-基}N-乙基-N-甲基亞氨基甲醯胺，(A081) 甲芬氟康唑，(A082) 氯氟醚菌唑，(A083) 1-(2,4-二氟苯基)-2-(1H-1,2,4-三唑-1-基)-1-[1-(2,6-二氟-4-氯苯氧基)環丙基]乙醇，(A084) 1-[2-(l-氯環丙基)-3-(2-氟苯基)-2-羥基丙基]-1H-咪唑-5-腈； (B) 呼吸鏈複合體I或II抑制劑，例如，(B001) 苯並烯氟菌唑，(B002) 聯苯吡菌胺，(B003) 啶醯菌胺，(B004) 萎鏽靈，(B005) 氟吡菌醯胺，(B006) 氟醯胺，(B007) 氟唑菌醯胺，(B008) 呋吡菌胺，(B009) 異丙噻菌胺，(B010) 吡唑萘菌胺 (抗差向異構體1R,4S,9S)，(B011) 吡唑萘菌胺 (抗差向異構體1S,4R,9R)，(B012) 吡唑萘菌胺 (抗差向異構消旋體1RS,4SR,9SR)，(B013) 吡唑萘菌胺 (同向異構消旋體1RS、4SR、9RS和抗差向異構消旋體1RS、4SR、9SR的混合物)，(B014) 吡唑萘菌胺 (同差向異構體1R,4S,9R)，(B015) 吡唑萘菌胺 (同差向異構體1S,4R,9S)，(B016) 吡唑萘菌胺 (同向異構消旋體1RS,4SR,9RS)，(B017) 氟唑菌苯胺，(B018) 吡噻菌胺，(B019) 氟唑菌醯羥胺，(B020) 琥珀酸脫氫酶抑制劑，(B021) 氟唑環菌胺，(B022) 1,3-二甲基-N-(1,1,3-三甲基-2,3-二氫-lH-茚-4-基)-lH-吡唑-4-甲醯胺，(B023) 1,3-二甲基-N-[(3R)-1,l,3-三甲基-2,3-二氫-1H-茚-4-基]-1H-吡唑-4-甲醯胺，(B024) l,3-二甲基-N-[(3S)-1,1,3-三甲基-2,3-二氫- lH-茚-4-基]-1H-吡唑-4-甲醯胺，(B025) l-甲基-3-(三氟甲基)-N-[2'-(三氟甲基)bi苯基-2-基]-1H-吡唑-4-甲醯胺，(B026) 2-氟-6-(三氟甲基)-N-(1,1,3-三甲基-2,3-二氫-lH-茚-4-基)苯甲醯胺，(B027) 3-(二氟甲基)-1-甲基-N-(1,1,3-三甲基-2,3-二氫-1H-茚-4-基)-lH吡唑-4-甲醯胺，(B028) 3-(二氟甲基)-1-甲基-N-[(3R)-1,1,3-三甲基-2,3-二氫-lH茚-4-基]-lH-吡唑-4-甲醯胺 (氟蟲胺)，(B029) 3-(二氟甲基)-1-甲基-N-[(3S)-1,1,3-三甲基-2,3-二氫-lH-茚-4-基]-lH-吡唑-4-甲醯胺，(B030) 3-(二氟甲基)-N-(7-氟-1,1,3-三甲基-2,3-二氫-lH-茚-4-基)-1-甲基-1H-吡唑-4-甲醯胺 (氟茚唑菌胺)，(B031) 3- (二氟甲基)-N-[(3R)-7-氟-l,1,3-三甲基-2,3-二氫-lH-茚-4-基]-1-甲基-1H-吡唑-4-甲醯胺，(B032) 3-(二氟甲基)-N-[(3S)-7-氟-1,1,3-三甲基-2,3-二氫-1H-茚-4-基]-1-甲基-lH-吡唑-4-甲醯胺，(B033) 5,8-二氟-N-[2-(2-氟-4-{[4-(三氟甲基)吡啶-2-基]氧基}苯基)乙基]喹唑啉-4-胺，(B034) N-(2-環戊基-5-氟苄基)-N-環丙基-3-(二氟甲基)-5-氟-1-甲基-l-H-吡唑-4-甲醯胺，(B035) N-(2-叔丁基-5-甲基苄基)-N-環丙基-3-(二氟甲基)-5-氟-1-甲基-1H吡唑-4-甲醯胺，(B036) N-(2-叔丁基苄基)-N-環丙基-3-(二氟甲基)-5-氟-1-甲基-1H-吡唑-4-甲醯胺，(B037) N-(5-氯-2-乙基苄基)-N-環丙基-3-(二氟甲基)-5-氟-1-甲基-1H-吡唑-4-甲醯胺，(B038) N-(5-氯-2-異丙基苄基)-N-環丙基-3-(二氟甲基)-5-氟-1-甲基-lH-吡唑-4-甲醯胺，(B039) N-[(1R,4S)-9-(二氯亞甲基)-1,2,3,4-四氫-1,4-甲撐萘-5-基]-3-(二氟甲基)-1-甲基-1H-吡唑-4-甲醯胺，(B040) N-[(1S,4R)-9-(二氯亞甲基)-1,2,3,4-四氫-1,4-甲撐萘-5-基]-3-(二氟甲基)-1-甲基-1H-吡唑-4-甲醯胺，(B041) N-[1-(2,4-二氟苯基)-l-甲氧基丙烷-2-基]-3-(二氟甲基)-1-甲基1H-吡唑-4-甲醯胺，(B042) N-[2-氯-6-(三氟甲基)苄基]-N-環丙基-3-(二氟甲基)-5-氟-1-甲基-1H-吡唑-4-甲醯胺，(B043) N-[3-氯-2-氟-6-(三氟甲基)苄基]-N-環丙基-3-(二氟甲基)-5-氟-1-甲基-1H-吡唑-4-甲醯胺，(B044) N-[5-氯-2-(三氟甲基)苄基]-N-環丙基-3-(二氟甲基)-5-氟-1-甲基-1H-吡唑-4-甲醯胺，(B045) N-環丙基-3-(二氟甲基)-5-氟-1-甲基-N-[5-甲基-2-(三氟甲基)苄基]-1H-吡唑-4-甲醯胺，(B046) N-環丙基-3-(二氟甲基)-5-氟-N-(2-氟-6-異丙基苄基)-1-甲基-1H-吡唑-4-甲醯胺，(B047) N-環丙基-3-(二氟甲基)-5-氟-N-(2-異丙基-5-甲基苄基)-1-甲基-1H吡唑-4-甲醯胺，(B048) N-環丙基-3-(二氟甲基)-5-氟-N-(2-異丙基苄基)-1-甲基-IH-吡唑-4-硫代醯胺，(B049) N-環丙基-3-(二氟甲基)-5-氟-N-(2-異丙基苄基)-1-甲基-1H-吡唑-4-甲醯胺，(B050) N-環丙基-3-(二氟甲基)-5-氟-N-(5-氟-2-異丙基苄基)-1-甲基-lH-吡唑-4-甲醯胺，(B051) N-環丙基-3-(二氟甲基)-N-(2-乙基-4,5-二甲基苄基)-5-氟-1-甲基-1H-吡唑-4-甲醯胺，(B052) N-環丙基-3-(二氟甲基)-N-(2-乙基-5-氟苄基)-5-氟-1-甲基-1H-吡唑-4-甲醯胺，(B053) N-環丙基-3-(二氟甲基)-N-(2-乙基-5-甲基苄基)-5-氟-1-甲基-1H-吡唑-4-甲醯胺，(B054) N-環丙基-N-(2-環丙基-5-氟苄基)-3-(二氟甲基)-5-氟-1-甲基-lH-吡唑-4-甲醯胺，(B055) N-環丙基-N-(2-環丙基-5-甲基苄基)-3-(二氟甲基)-5-氟-1-甲基-1H-吡唑-4-甲醯胺，(B056) N-環丙基-N-(2-環丙基苄基)-3-(二氟甲基)-5-氟-1-甲基-1H-吡唑-4-甲醯胺，(B057) 2-(二氟甲基)-N-(l,1-二甲基-3-丙基-2,3-二氫-1H-茚-4- 基)煙醯胺，(B058) 吡唑醯胺； (C) 呼吸鏈複合體III抑制劑，例如，(C001) 唑嘧菌胺，(C002) 吲唑磺菌胺，(C003) 腈嘧菌酯，(C004) 甲香菌酯，(C005) 丁香菌酯，(C006) 氰霜唑，(C007) 醚菌胺，(C008) 烯肟菌酯，(C009) 惡唑菌酮，(C010) 咪唑菌酮，(C011) 氟菌蟎酯，(C012) 氟嘧菌酯，(C013) 醚菌酯，(C014) 苯氧菌胺，(C015) 肟醚菌胺，(C016) 啶氧菌酯，(C017) 唑菌胺酯，(C018) 唑胺菌酯，(C019) 唑菌酯，(C020) 肟菌酯，(C021)(2E)-2-{2-[({[(1E)-1-(3-{[(E)-1-氟-2-苯基乙烯基]氧基} 苯基)亞乙基]氨基}氧基)甲基]苯基}-2-(甲氧基亞氨基)-N-甲基乙醯胺，(C022) (2E,3Z)-5-{[1-(4-氟苯基)-lH-吡唑-3-基]氧基}-2-(甲氧基亞氨基)-N,3-二甲基戊基-3-烯胺，(C023) (2R)-2-{2-[(2,5-二甲基苯氧基)甲基]苯基}-2-甲氧基-N-甲基乙醯胺，(C024) (2S)-2-{2-[(2,5-二甲基苯氧基)甲基]苯基}-2-甲氧基-N-甲基乙醯胺，(C025) (3S,6S,7R,8R)-8-苄基-3-[({3-[(異丁醯氧基)甲氧基]-4-甲氧基吡啶-2-基}羰基)氨基]-6-甲基-4,9-二氧-1,5-二惡茂烷-7-基-2-丙酸甲酯 (苯呱沙米)，(C026) 2-{2-[(2,5-二甲基苯氧基)甲基]苯基}-2-甲氧基-N-甲基乙醯胺 (甲氧基丙烯酸酯類殺菌劑)，(C027) N-(3-乙基-3,5,5-三甲基環己基)-3-甲醯胺-2-羥基苯甲醯胺，(C028) (2E,3Z)-5-{[1-(4-氯-2-氟苯基)-lH-吡唑-3-基]氧基}-2-(甲氧基亞氨基)-N,3-二甲基戊基-3-烯胺，(C029) 甲基{5-[3-(2,4-二甲基苯基)-lH-吡唑-1-基]-2-甲基苄基}氨基甲酸酯，(C030) 1-(2-{[1-(4-氟苯基)吡唑-3-基]氧基甲基}-3-甲基苯基)-1,4-二氫-4-甲基-5H-四唑-5-酮 (本基吡唑)，(C031) 吡啶醯胺類殺菌劑； (E) 具有多重作用的化合物，例如 (E001) 波爾多混合劑，(E002) 敵菌丹，(E003) 克菌丹，(E004) 百菌清，(E005) 氫氧化銅，(E006) 環烷酸銅，(E007) 氧化銅，(E008) 氯氧化銅，(E009) 硫酸銅(2+)，(E010) 二噻農，(E011) 多果定，(E012) 滅菌丹，(E013) 代森錳鋅，(E014) 代森錳，(E015) 代森聯，(E016) 代森聯鋅，(E017) 喹啉銅，(E018) 甲基代森鋅，(E019) 硫和硫製劑，包括多硫化鈣，(E020) 福美雙，(E021) 代森鋅，(E022) 福美鋅，(E023) 6-乙基-5,7-二氧-6,7-二氫-5H吡咯並[3',4':5,6][1,4]二噻農[2,3-c][1,2]噻唑-3-腈； (L) (L003) 甲霜靈，(L004) 甲霜靈-M (精甲霜靈)， (M) (M001) 咯菌腈，(M002) 異菌脲，(M004) 丙氧喹啉，(M005) 喹氧靈， (N) (N001) 氟啶胺，(N002) 消蟎多， (O) 其他化合物，例如 (O001) 脫落酸，(O002) 苯噻硫氰，(O003) 苯惡嗪，(O004) 卡巴西黴素，(O005) 香芹酮，(O006) 滅蟎猛，(O007) 硫雜靈，(O008) 環氟菌胺，(O009) 霜脲氰，(O010) 環丙磺醯胺，(O011) 氟替尼，(O012) 三乙膦酸鋁，(O013) 三乙膦酸鈣，(O014) 酸鈉，(O015) 異硫氰酸甲酯，(O016) 苯菌酮，(O017) 米多黴素，(O018) 納他黴素，(O019) 福美鎳，(O020) 酞菌酯，(O021) 惡草威，(O022) 氟噻唑吡乙酮，(O023) 氧芬硫醇，(O024) 五氯苯酚和鹽，(O025) 磷酸及其鹽類，(O026) 霜黴威乙膦酸鹽，(O027) 甲氧苯唳菌 (氯氮酮)，(O028) 異丁乙氧喹啉，(O029) 葉枯酞，(O030) 甲磺菌胺，(O031) 1-(4-{4-[(5R)-5-(2,6-二氟苯基)-4,5-二氫-l,2-惡唑-3-基]-l,3-噻唑-2-基}呱啶-1-基)-2-[5-甲基-3-(三氟甲基)-1H-吡唑-1-基]乙酮，(O032) 1-(4-{4-[(5S)-5-(2,6-二氟苯基)-4,5-二氫-l,2-惡唑-3-基]-l,3-噻唑-2-基}呱啶-1-基)-2-[5-甲基-3-(三氟甲基)-lH-吡唑-l-基]乙酮，(O033) 2-(6-苄基吡啶-2-基)喹唑啉，(O034) 2,6-二甲基-1H,5H-[1,4]二噻農[2,3-c:5,6-c']二吡咯-1,3,5,7(2H,6H)-四酮，(O035) 2-[3,5-雙(二氟甲基)-lH-吡唑-1-基]-1-[4-(4-{5-[2-(丙基-2-炔-1-基氧基)苯基]-4,5-二氫-l,2-惡唑-3-基}-l,3-噻唑-2-基)呱啶-1-基]乙酮，(O036) 2-[3,5-雙(二氟甲基)-1H-吡唑-1-基]-1-[4-(4-{5-[2-氯-6-(丙基-2-炔-1-基氧基)苯基]-4,5-二氫-1,2-惡唑-3-基}-1,3-噻唑-2-基)呱啶-1-基]乙酮，(O037) 2-[3,5-雙(二氟甲基)-lH-吡唑-1-基]-1-[4-(4-{5-[2-氟-6-(丙基-2-炔-1-基氧基)苯基]-4,5-二氫- l,2-惡唑-3-基}-l,3-噻唑-2-基)呱啶-1-基]乙酮，(O038) 2-[6-(3-氟-4-甲氧基苯基)-5-甲基吡啶-2-基]喹唑啉，(O039) 2-{(5R)-3-[2-(1-{[3,5-雙(二氟甲基)-lH-吡唑-1-基]乙醯基}呱啶-4-基)-1,3-噻唑-4-基]-4,5-二氫-l,2-惡唑-5-基}-3-氟苯基 甲磺酸鹽，(O040) 2-{(5S)-3-[2-(1-{[3,5-雙(二氟甲基)-1H-吡唑-1-基]乙醯基}呱啶-4-基)-1,3-噻唑-4-基]-4,5-二氫-1,2-惡唑-5-基}-3-氟苯基 甲磺酸鹽，(O041) 2-{2-[(7,8-二氟-2-甲基喹啉-3-基)氧基]-6-氟苯基}丙烷-2-醇，(O042) 2-{2-氟-6-[(8-氟-2-甲基喹啉-3-基)氧基]苯基}丙烷-2-醇，(O043) 2-{3-[2-(1-{[3,5-雙(二氟甲基)-1H-吡唑-1-基]乙醯基}呱啶-4-基)-1,3-噻唑-4-基]-4,5-二氫-1,2-惡唑-5-基}-3-氟苯基 甲磺酸鹽 (拜耳“奇葩”殺菌劑)，(O045) 2-苯基苯酚和鹽，(O046) 3-(4,4,5-三氟-3,3-二甲基-3,4-二氫異喹啉-1-基)喹啉，(O047) 3-(4,4-二氟-3,3-二甲基-3,4-二氫異喹啉-1-基)喹啉 (喹啉類殺菌劑)，(O048) 4-氨基-5-氟嘧啶-2-醇 (互變異構體：4-氨基-5- 氟嘧啶-2(1H)-酮)，(O049) 4-氧代-4-[(2-苯基乙基)氨基]丁酸，(O050) 5-氨基-1,3,4-噻二唑-2-硫醇，(O051) 5-氯-N'-苯基-N'-(丙基-2-炔-1-基)噻吩-2-磺醯肼，(O052) 5-氟-2-[(4-氟苄基)氧基]嘧啶-4-胺，(O053) 5-氟-2-[(4-甲基苄基)氧基]嘧啶-4-胺，(O054) 9-氟-2,2-二甲基-5-(喹啉-3-基)-2,3-二氫-1,4-苯氧氮平，(O055) but-3-炔-1-基{6-[({[(Z)-(l-甲基-1H-四唑-5-基)(苯基)亞甲基]氨基}氧基)甲基]吡啶-2-基}氨基甲酸酯，(O056) 乙基(2Z)-3-氨基-2-氰基-3-丙烯酸苯酯，(O057) 吩嗪-1-羧酸，(O058) 丙基 3,4,5-三羥基苯甲酯，(O059) 喹啉-8-醇，(O060) 喹啉-8-醇 硫酸鹽 (2:1)，(O061) 叔丁基 {6-[({[(1-甲基-1H-四唑-5-基)(苯基)亞甲基]氨基}氧基)甲基]吡啶-2-基}氨基甲酸酯，(O062) 5-氟-4-亞氨基-3-甲基-1-[(4-甲基苯基)磺醯基]-3,4-二氫嘧啶-2(1H)-酮，(O063) 吡啶氯甲基，(O064) 異氟苯諾喹，(O065) 廣譜吡啶類殺菌劑， (P) 組蛋白去乙醯化酶抑制劑，例如(P001) N-(1-乙基環丙基)-4-[5-(三氟甲基)-1,2,4-惡二唑-3-基]苯甲醯胺；(P002) N-(2-異丙基環丙基)-4-[5-(三氟甲基)-1,2,4-惡二唑-3-基]苯甲醯胺；(P003) N-(2-甲基環丙基)-4-[5-(三氟甲基)-1,2,4-惡二唑-3-基]苯甲醯胺；(P004) N-(1-甲基環丙基)-4-[5-(三氟甲基)-1,2,4-惡二唑-3-基]苯甲醯胺；(P005) N-(2-乙基環丙基)-4-[5-(三氟甲基)-1,2,4-惡二唑-3-基]苯甲醯胺；(P006) N-(2,4-二氟苯基)-4-[5-(三氟甲基)-1,2,4-惡二唑-3-基]苯甲醯胺；(P007) 5-(三氟甲基)-3-[4-[[3-(三氟甲基)-1,2,4triazol-1-基]甲基]苯基]-1,2,4-惡二唑；(P008) 2-[[4-[5-(三氟甲基)-1,2,4-惡二唑-3-基]苯基]甲基]-1,2,4-三唑-3-腈；(P009) 乙基 1-[[4-[5-(三氟甲基)-1,2,4-惡二唑-3-基]苯基]甲基]吡唑-4-羧酸鹽；(P010) N-環丙基-1-[[4-[5-(三氟甲基)-1,2,4-惡二唑-3-基]苯基]甲基]吡唑-4-甲醯胺；(P011) N,N-二甲基-1-[[4-[5-(三氟甲基)-1,2,4-惡二唑-3-基]苯基]甲基]吡唑-4-甲醯胺；(P012) N-甲基-1-[[4-[5-(三氟甲基)-1,2,4-惡二唑-3-基]苯基]甲基]吡唑-4-甲醯胺；(P013) N,N,-二甲基-H[4-[5-(三氟甲基)-1,2,4-惡二唑-3-基]苯基]甲基]-1,2,4-三唑-3-胺；(P014) 3-[4-[(5-乙基磺醯基-1,2,4-三唑-1-基)甲基]苯基]-5-(三氟甲基)-1,2,4-惡二唑；(P015) 3-[4-(三唑[4,5-b]吡啶-1-基甲基)苯基]-5-(三氟甲基)-1,2,4-惡二唑；(P016) 3-[4-(三唑[4,5-b]吡啶-2-基甲基)苯基]-5-(三氟甲基)-1,2,4-惡二唑；(P017) 3-[4-(三唑[4,5-b]吡啶-3-基甲基)苯基]-5-(三氟甲基)-1,2,4-惡二唑；(P018) 甲基 1-[[4-[5-(三氟甲基)-1,2,4-惡二唑-3-基]苯基]甲基]吡唑-4-羧酸鹽；(P019) 乙基 1-[[3-氟-4-[5-(三氟甲基)-1 ,2,4-惡二唑-3-基]苯基]甲基]吡唑-4-羧酸鹽；(P020)N,N- 二乙基-1-[[4-[5-(三氟甲基)-1,2,4-惡二唑-3-基]苯基]甲基]吡唑-4-甲醯胺；(P021)N -甲氧基-N -甲基-1-[[4-[5-(三氟甲基)-1,2,4-惡二唑-3-基]苯基]甲基]吡唑-4-甲醯胺；(P022) 丙基 1-[[4-[5-(三氟甲基)-1,2,4-惡二唑-3-基]苯基]甲基]吡唑-4-羧酸鹽；(P023)N -甲氧基-1-[[4-[5-(三氟甲基)-1,2,4-惡二唑-3-基]苯基]甲基]吡唑-4-甲醯胺；(P024)N -乙基-1-[[4-[5-(三氟甲基)-1,2,4-惡二唑-3-基]苯基]甲基]吡唑-4-甲醯胺；(P025) 1-[[4-[5-(三氟甲基)-1,2,4-惡二唑-3-基]苯基]甲基]吡唑-4-甲醯胺；(P026)N -甲氧基-1-[1-[[4-[5-(三氟甲基)-1,2,4-惡二唑-3-基]苯基]甲基]吡唑-4-基]亞胺；(P027) 乙基 1-[1-[4-[5-(三氟甲基)-1,2,4-惡二唑-3-基]苯基]乙基]吡唑-4-羧酸鹽；(P028) 1-[[4-[5-(三氟甲基)-1,2,4-惡二唑-3-基]苯基]甲基]吡咯烷-2-酮；(P029) 1-[[4-[5-(三氟甲基)-1,2,4-惡二唑-3-基]苯基]甲基]呱啶-2-酮；(P030) 4-[[4-[5-(三氟甲基)-1,2,4-惡二唑-3-基]苯基]甲基]嗎啉-3-酮；(P031) 4,4-二甲基-2-[[4-[5-(三氟甲基)-1,2,4-惡二唑-3-基]苯基]甲基]異惡唑啉-3-酮；(P032) 2-[[4-[5-(三氟甲基)-1,2,4-惡二唑-3-基]苯基]甲基]異惡唑啉-3-酮；(P033) 5,5-二甲基-2-[[4-[5-(三氟甲基)-1 ,2,4-惡二唑-3-基]苯基]甲基]異惡唑啉-3-酮；(P034) 3,3-二甲基-1-[[4-[5-(三氟甲基)-1 ,2,4-惡二唑-3-基]苯基]甲基]呱啶-2-酮；(P035) 1-[[2-氟-4-[5-(三氟甲基)-1,2,4-惡二唑-3-基]苯基]甲基]吡咯烷-2-酮；(P036) 1-[[2-氟-4-[5-(三氟甲基)-1,2,4-惡二唑-3-基]苯基]甲基]呱啶-2-酮；(P037) 2-[[4-[5-(三氟甲基)-1,2,4-惡二唑-3-基]苯基]甲基]惡嗪-3-酮；(P038) 1-[[3-氟-4-[5-(三氟甲基)-1,2,4-惡二唑-3-基]苯基]甲基]呱啶-2-酮；(P039) 3-[[4-[5-(三氟甲基)-1,2,4-惡二唑-3-基]苯基]甲基]唑烷-2-酮；(P040) 1-甲基-3-[[4-[5-(三氟甲基)-1,2,4-惡二唑-3-基]苯基]甲基]咪唑啉啶-2-酮；(P041) 1-[[3-氟-4-[5-(三氟甲基)-1,2,4-惡二唑-3-基]苯基]甲基]-3,3-二甲基-呱啶-2-酮；(P042) 1-[[3-氟-4-[5-(三氟甲基)-1,2,4-惡二唑-3-基]苯基]甲基]吡咯烷-2-酮；(P043) 2-[[3-氟-4-[5-(三氟甲基)-1,2,4-惡二唑-3-基]苯基]甲基]-4,4-二甲基-異惡唑啉-3-酮；(P044) 2-[[2,3-二氟-4-[5-(三氟甲基)-1,2,4-惡二唑-3-基]苯基]甲基]異惡唑啉-3-酮；(P045) 2-[[3-氟-4-[5-(三氟甲基)-1,2,4-惡二唑-3-基]苯基]甲基]異惡唑啉-3-酮；(P046) 1-[[3-氟-4-[5-(三氟甲基)-1,2,4-惡二唑-3-基]苯基]甲基]氮雜烷-2-酮；(P047) N-[[4-[5-(三氟甲基)-1,2,4-惡二唑-3-基]苯基]甲基]丙醯胺；(P048) 2,2-二甲基-N-[[4-[5-(三氟甲基)-1,2,4-惡二唑-3-基]苯基]甲基]丁基-3-炔醯胺；(P049) N-[[4-[5-(三氟甲基)-1,2,4-惡二唑-3-基]苯基]甲基]丁醯胺；(P050) 3-甲基-N-[[4-[5-(三氟甲基)-1,2,4-惡二唑-3-基]苯基]甲基]丁醯胺；(P051) 2-甲基-N-[[4-[5-(三氟甲基)-1,2,4-惡二唑-3-基]苯基]甲基]丙基-2-烯胺；(P052) 2-甲基-N-[[4-[5-(三氟甲基)-1,2,4-惡二唑-3-基]苯基]甲基]丁醯胺；(P053) 2-甲氧基-N-[[4-[5-(三氟甲基)-1,2,4-惡二唑-3-基]苯基]甲基]；(P054) 3,3,3-三氟-N-[[3-氟-4-[5-(三氟甲基)-1,2,4-惡二唑-3-基]苯基]甲基]丙醯胺；(P055) 3,3,3-三氟-N-[[2-氟-4-[5-(三氟甲基)-1,2,4-惡二唑-3-基]苯基]甲基]丙醯胺；(P056) N-[[2,3-二氟-4-[5-(三氟甲基)-1,2,4-惡二唑-3-基]苯基]甲基]丁醯胺；(P057) N-[[2,3-二氟-4-[5-(三氟甲基)-1,2,4-惡二唑-3-基]苯基]甲基]-3,3,3-三氟-丙醯胺；(P058) 2-(二氟甲氧基)-N-[[4-[5-(三氟甲基)-1,2,4-惡二唑-3-基]苯基]甲基]乙醯胺；(P059) 2-甲氧基-2-甲基-N-[[4-[5-(三氟甲基)-1,2,4-惡二唑-3-基]苯基]甲基]丙醯胺；(P060) 1-甲基-3-[[4-[5-(三氟甲基)-1,2,4-惡二唑-3-基]苯基]甲基]脲；(P061) 1-乙基-1-甲基-3-[[4-[5-(三氟甲基)-1,2,4-惡二唑-3-基]苯基]甲基]脲；(P062) 1-乙氧基-3-[[4-[5-(三氟甲基)-1,2,4-惡二唑-3-基]苯基]甲基]脲；(P063) 1-甲氧基-1-甲基-3-[[4-[5-(三氟甲基)-1,2,4-惡二唑-3-基]苯基]甲基]脲；(P064) 1,1-二乙基-3-[[4-[5-(三氟甲基)-1 ,2,4-惡二唑-3-基]苯基]甲基]脲；(P065) N-甲氧基-N-[[4-[5-(三氟甲基)-1,2,4-惡二唑-3-基]苯基]甲基]環丙烷甲醯胺；(P066) N-甲氧基-N-[[4-[5-(三氟甲基)-1,2,4-惡二唑-3-基]苯基]甲基] 戊基-4-炔醯胺；(P067) N-甲氧基-2-甲基-N-[[4-[5-(三氟甲基)-1,2,4-惡二唑-3-基]苯基]甲基]丙基-2-烯胺；(P068) N,2-二甲氧基-N-[[4-[5-(三氟甲基)-1,2,4-惡二唑-3-基]苯基]甲基]丙醯胺；(P069) N-環丙基-3,3,3-三氟-N-[[4-[5-(三氟甲基)-1,2,4-惡二唑-3-基]苯基]甲基]丙醯胺；(P070) 2,2-二氟-N-(2-甲氧基乙基)-N-[[4-[5-(三氟甲基)-1,2,4-惡二唑-3-基]苯基]甲基]環丙烷甲醯胺；(P071) N-乙基-2-甲基-N-[[4-[5-(三氟甲基)-1,2,4-惡二唑-3-基]苯基]甲基]丙醯胺；(P072) N-[[3-氟-4-[5-(三氟甲基)-1,2,4-惡二唑-3-基]苯基]甲基]-N-甲氧基-丙醯胺；(P073) 2-甲氧基-N-(2,2,2-三氟乙基)-N-[[4-[5-(三氟甲基)-1,2,4-惡二唑-3-基]苯基]甲基]乙醯胺；(P074) N-[[2,3-二氟-4-[5-(三氟甲基)-1,2,4-惡二唑-3-基]苯基]甲基]-N-甲氧基-環丙烷甲醯胺；(P075) 2-(二氟甲氧基)-N-甲基-N-[[4-[5-(三氟甲基)-1,2,4-惡二唑-3-基]苯基]甲基]乙醯胺；(P076) N-乙氧基-2-甲氧基-N-[[4-[5-(三氟甲基)-1,2,4-惡二唑-3-基]苯基]甲基]丙醯胺；(P077) N-異丙基-N-[[4-[5-(三氟甲基)-1,2,4-惡二唑-3-基]苯基]甲基]四氫呋喃-2-甲醯胺；(P078) 1-甲氧基-3-甲基-1-[[4-[5-(三氟甲基)-1,2,4-惡二唑-3-基]苯基]甲基]脲；(P079) 3-環丙基-1-甲氧基-1-[[4-[5-(三氟甲基)-1,2,4-惡二唑-3-基]苯基]甲基]脲；(P080) 3-乙氧基-1-甲氧基-1-[[4-[5-(三氟甲基)-1,2,4-惡二唑-3-基]苯基]甲基]脲；(P081) 3-烯丙基-1-甲氧基-1-[[4-[5-(三氟甲基)-1,2,4-惡二唑-3-基]苯基]甲基]脲；(P082) 1-環丙基-3-甲氧基-3-甲基-1-[[4-[5-(三氟甲基)-1,2,4-惡二唑-3-基]苯基]甲基]脲；(P083) 3-異丙基-1-甲氧基-1-[[4-[5-(三氟甲基)-1,2,4-惡二唑-3-基]苯基]甲基]脲；(P084) 1-甲氧基-3-丙基-2-炔基-1-[[4-[5-(三氟甲基)-1,2,4-惡二唑-3-基]苯基]甲基]脲；(P085) 1-[[3-氟-4-[5-(三氟甲基)-1,2,4-惡二唑-3-基]苯基]甲基]-1-甲氧基-3-甲基-脲；(P086) 3-(環丙基甲基)-1-甲基-1-[[4-[5-(三氟甲基)-1,2,4-惡二唑-3-基]苯基]甲基]脲；(P087) 1-乙基-3-(2,2,2-三氟乙基)-1-[[4-[5-(三氟甲基)-1,2,4-惡二唑-3- 基]苯基]甲基]脲；(P088) 1,3-二甲氧基-1-[[4-[5-(三氟甲基)-1,2,4-惡二唑-3-基]苯基]甲基]脲；(P089) 3-乙基-1-甲氧基-1-[[4-[5-(三氟甲基)-1,2,4-惡二唑-3-基]苯基]甲基]脲；(P090) N-甲基-4-[5-(三氟甲基)-1,2,4-惡二唑-3-基]苯甲醯胺；(P091) N-[(E)-甲氧基亞氨基甲基]-4-[5-(三氟甲基)-1,2,4-惡二唑-3-基]苯甲醯胺；(P092) N-[(Z)-甲氧基亞氨基甲基]-4-[5-(三氟甲基)-1,2,4-惡二唑-3-基]苯甲醯胺；(P093) N-[4-[5-(三氟甲基)-1,2,4-惡二唑-3-基]苯基]環丙烷甲醯胺；(P094) N-(2-氟苯基)-4-[5-(三氟甲基)-1,2,4-惡二唑-3-基]苯甲醯胺；(P095) 2,2-二氟-N-甲基-2-[4-[5-(三氟甲基)-1,2,4-惡二唑-3-基]苯基]乙醯胺；(P096) N-烯丙基-N-[[4-[5-(三氟甲基)-1,2,4-惡二唑-3-基]苯基]甲基]乙醯胺；(P097) N-[(E)-N-甲氧基-C-甲基-碳亞氨基]-4-[5-(三氟甲基)-1,2,4-惡二唑-3-基]苯甲醯胺；(P098) N-[(Z)-N-甲氧基-C-甲基-碳亞氨基]-4-[5-(三氟甲基)-1,2,4-惡二唑-3-基]苯甲醯胺；(P100) N-烯丙基-N-[[4-[5-(三氟甲基)-1,2,4-惡二唑-3-基]苯基]甲基]丙醯胺；(P101) 4,4-二甲基-1-[[4-[5-(三氟甲基)-1,2,4-惡二唑-3-基]苯基]甲基]吡咯烷-2-酮；(P102) N-甲基-4-[5-(三氟甲基)-1,2,4-惡二唑-3-基]苯甲硫醯胺；(P104) N-甲基-4-[5-(三氟甲基)-1,2,4-惡二唑-3-基]苯甲甲醯胺；(P104) N1-甲基-N2-(4-(5-(三氟甲基)-1,2,4-惡二唑-3-基)苄基)草醯胺。 (Q) Q001) 1-(2,4-二氟苯基)-5-(乙氧基羰基)-5-甲基-2-吡唑啉-3-羧酸，(Q002) 乙基 1-(2,4-二氟苯基)-5-(乙氧基羰基)-5-甲基-2-吡唑啉-3-羧酸鹽 ("吡唑解草酯 (-二乙基)")。A particularly preferred composition of the compound (I) of the present invention contains at least one of the following active compounds (2): (A) an ergosterol biosynthesis inhibitor, for example, (A001) cyproconazole, (A002) phenyl ether Meticonazole, (A003) epoxiconazole, (A004) fenpropanil, (A005) fenpropidin, (A006) fenpropidol, (A007) fenpyridone, (A008) fluquinazole, (A009) Fenconazole, (A010) imazalil, (A011) imazalil sulfate, (A012) imazalil, (A013) metconazole, (A014) myclobutanol, (A015) paclobutrazol, (A016) Prochloraz, (A017) Proiconazole, (A018) Prothioconazole, (A019) Picoconazole, (A020) Spirostrobin, (A021) Tebuconazole, (A022) Flufenconazole, (A023) ) Triadimenol, (A024) Tridecamorph, (A025) Triazole, (A026) (1R,2S,5S)-5-(4-chlorobenzyl)-2-(chloromethyl)-2- Methyl-1-(lH-1,2,4-triazol-1-ylmethyl)cyclopentanol, (A027) (1S,2R,5R)-5-(4-chlorobenzyl)-2-( Chloromethyl)-2-methyl-1-(1H-1,2,4-triazol-1-ylmethyl)cyclopentanol, (A028) (2R)-2-(l-chlorocyclopropyl )-4-[(1R)-2,2-Dichlorocyclopropyl]-l-(lH-1,2,4-triazol-1-yl)butan-2-ol, (A029) (2R )-2-(l-chlorocyclopropyl)-4-[(lS)-2,2-dichlorocyclopropyl]-1-(lH-1,2,4-triazol-1-yl)butan Alkan-2-ol, (A030) (2R)-2-[4-(4-chlorophenoxy)-2-(trifluoromethyl)phenyl]-1-(1H-1,2,4- Triazol-1-yl)propane-2-ol, (A031) (2S)-2-(1-chlorocyclopropyl)-4-[(1R)-2,2-dichlorocyclopropyl]-1 -(1H-l,2,4-triazol-1-yl)butan-2-ol, (A032) (2S)-2-(1-chlorocyclopropyl)-4-((1S)-2 ,2-Dichlorocyclopropyl]-1-(1H-1,2,4-triazol-1-yl)butan-2-ol, (A033) (2S)-2-[4-(4- Chlorophenoxy)-2-(trifluoromethyl)phenyl]-1-(lH-1,2,4-triazol-1-yl)propan-2-ol, (A034) (R)-[ 3-(4-Chloro-2-fluorophenyl)-5-(2,4-difluorophenyl)-1,2-oxazol-4-yl](pyridin-3-yl)methanol, (A035) (S)(3-(4-Chloro-2-fluorophenyl)-5-(2,4-difluorophenyl)-l,2-oxazol-4-yl)(pyridine -3-yl)methanol, (A036) [3-(4-chloro-2-fluorophenyl)-5-(2,4-difluorophenyl)-1,2-oxazol-4-yl]( Pyridin-3-yl)methanol, (A037) 1-({(2R,4S)-2-[2-chloro-4-(4-chlorophenoxy)phenyl]-4-methyl-1,3 -Dioxolane-2-yl}methyl)-1H-1,2,4-triazole, (A038) 1-({(2S,4S)-2-[2-chloro-4-(4- Chlorophenoxy)phenyl]-4-methyl-1,3-dioxolane-2-yl}methyl)-1H-1,2,4-triazole, (A039)1-{[3 -(2-Fluorophenyl)-2-(2,4-difluorophenyl)oxyethylene-2-yl)methyl)-lH-1,2,4-triazol-5-yl thiocyanate , (A040) l-{[rel(2R,3R)-3-(2-fluorophenyl)-2-(2,4-difluorophenyl)oxyethylene-2-yl]methyl}-1H- 1,2,4-Triazol-5-yl thiocyanate, (A041) l-{[rel(2R,3S)-3-(2-fluorophenyl)-2-(2,4-difluoro Phenyl)oxyethylene-2-yl]methyl}-1H-1,2,4-triazol-5-yl thiocyanate, (A042) 2-[(2R,4R,5R)-1-( 2,4-Difluorophenyl)-5-hydroxy-2,6,6-trimethylheptan-4-yl)-2,4-dihydro-3H-1,2,4-triazole-3 -Thione, (A043) 2-[(2R,4R,5S)-1-(2,4-difluorophenyl)-5-hydroxy-2,6,6-trimethylheptan-4-yl ]-2,4-Dihydro-3H-1,2,4-triazole-3-thione, (A044) 2-[(2R,4S,5R)-l-(2,4-difluorophenyl )-5-hydroxy-2,6,6-trimethylheptan-4-yl]-2,4-dihydro-3H-1,2,4-triazole-3-thione, (A045) 2 -[(2R,4S,5S)-l-(2,4-difluorophenyl)-5-hydroxy-2,6,6-trimethylheptan-4-yl]-2,4-dihydro -3H-1,2,4-Triazole-3-thione, (A046)2-[(2S,4R,5R)-1-(2,4-difluorophenyl)-5-hydroxy-2, 6,6-Trimethylheptan-4-yl]-2,4-dihydro-3H-1,2,4-triazole-3-thione, (A047) 2-[(2S,4R,5S )-1-(2,4-Difluorophenyl)-5-hydroxy-2,6,6-trimethylheptan-4-yl)-2,4-dihydro-3H-1,2,4 -Triazole-3-thione, (A048) 2-[(2S,4S,5R)-1-(2,4-difluorophenyl)-5-hydroxy-2,6,6-trimethylheptane Alkyl-4-yl]-2,4-dihydro-3H-1,2,4-triazole-3-thione, (A049) 2-[(2S,4S,5S)-l-(2,4-difluorophenyl)-5-hydroxy-2,6,6-trimethylheptan-4-yl]-2,4-di Hydrogen-3H-1,2,4-triazole-3-thione, (A050) 2-[1-(2,4-difluorophenyl)-5-hydroxy-2,6,6-trimethyl Heptan-4-yl]-2,4-dihydro-3H-1,2,4-triazole-3-thione, (A051)2-[2-chloro-4-(2,4-dichloro Phenoxy)phenyl]-l-(1H-1,2,4-triazol-1-yl)propan-2-ol, (A052) 2-[2-chloro-4-(4-chlorophenoxy Yl)phenyl]-1-(lH-1,2,4-triazol-1-yl)butan-2-ol, (A053) 2-[4-(4-chlorophenoxy)-2- (Trifluoromethyl)phenyl]-1-(lH-1,2,4-triazol-1-yl)butan-2-ol, (A054) 2-[4-(4-chlorophenoxy )-2-(Trifluoromethyl)phenyl]-1-(1H-1,2,4-triazol-1-yl)pentane-2-ol, (A055) 2-[4-(4- Chlorophenoxy)-2-(trifluoromethyl)phenyl]-1-(lH-1,2,4-triazol-1-yl)propan-2-ol, (A056) 2-{[3 -(2-Fluorophenyl)-2-(2,4-difluorophenyl)oxyethylene-2-yl)methyl)-2,4-dihydro-3H-1,2,4-triazole- 3-thioketone, (A057) 2-{[rel(2R,3R)-3-(2-fluorophenyl)-2-(2,4-difluorophenyl)oxyethylene-2-yl]methyl }-2,4-Dihydro-3H-1,2,4-triazole-3-thione, (A058) 2-{[rel(2R,3S)-3-(2-fluorophenyl)-2 -(2,4-Difluorophenyl)oxyethylene-2-yl]methyl}-2,4-dihydro-3H-1,2,4-triazole-3-thione, (A059) 5- (4-Chlorobenzyl)-2-(chloromethyl)-2-methyl-1-(lH-1,2,4-triazol-1-ylmethyl)cyclopentanol, (A060) 5- (Allylsulfonyl)-1-{[3-(2-fluorophenyl)-2-(2,4-difluorophenyl)oxyethylene-2-yl]methyl)-1H-1, 2,4-Triazole, (A061) 5-(allylsulfonyl)-1-{[rel(2R,3R)-3-2-fluorophenyl)-2-(2,4-difluoro Phenyl)oxyethylene-2-yl]methyl}-1H-1,2,4-triazole, (A062) 5-(allylsulfonyl)-1-{[rel(2R,3S)- 3-(2-Fluorophenyl)-2-(2,4-difluorophenyl)oxyethylene-2-yl]methyl}-1H-1,2,4-triazole, (A063) N'- (2,5-Dimethyl-4-{[3-(1,1,2,2-tetrafluoroethoxy)phenyl]sulfonyl}phenyl)-N-ethyl -N-methyliminomethanamide, (A064) N'-(2,5-dimethyl-4-{[3-(2,2,2-trifluoroethoxy)phenyl]sulfonamide Yl}phenyl)N-ethyl-N-methyliminocarboxamide, (A065) N'-(2,5-dimethyl-4-{[3-(2,2,3,3- Tetrafluoropropoxy)phenyl]sulfonyl}phenyl)-N-ethyl-N-methyliminomethanamide, (A066) N'-(2,5-dimethyl-4-{ [3-(Pentafluoroethoxy)phenyl]sulfonyl}phenyl)-N-ethyl-N-methyliminomethamide, (A067) N'-(2,5-dimethyl -4-{3-[(1,l,2,2-tetrafluoroethyl)sulfonyl]phenoxy}phenyl)-N-ethyl-Nmethyliminomethanamide, (A068) N'-(2,5-Dimethyl-4-{3-[(2,2,2-trifluoroethyl)sulfonyl]phenoxy}phenyl)N-ethyl-N-methyl Iminomethamide, (A069) N'-(2,5-dimethyl-4-{3-[(2,2,3,3-tetrafluoropropyl)sulfonyl]phenoxy}benzene Yl)-N-ethyl-N-methyliminocarboxamide, (A070) N'-(2,5-dimethyl-4-{3-[(pentafluoroethyl)sulfonyl]benzene Oxy}phenyl)-N-ethyl-N-methyliminocarbamide, (A071) N'-(2,5-dimethyl-4-phenoxyphenyl)-N-ethyl -N-Methyliminomethanamide, (A072) N'-(4-{[3-(difluoromethoxy)phenyl]sulfonyl}-2,5-dimethylphenyl)- N-ethyl-N-methyliminomethanamide, (A073) N'(4-{3-[(difluoromethyl)sulfonyl]phenoxy}-2,5-dimethylbenzene Yl)-N-ethyl-N-methyliminocarboxamide, (A074) N'-[5-bromo-6-(2,3-dihydro-lH-inden-2-yloxy)- 2-Methylpyridin-3-yl]-N-ethyl-N methyliminocarboxamide, (A075) N'-{4-[(4,5-Dichloro-1,3-thiazole-2 -Yl)oxy]-2,5-dimethylphenyl}-Nethyl-N-methyliminocarboxamide, (A076) N'-{5-bromo-6-[(1R)- 1-(3,5-Difluorophenyl)ethoxy]-2-methylpyridin-3-yl}-N-ethyl-N-methyliminomethanamide, (A077)N'-{ 5-bromo-6-[(1S)-1-(3,5-difluorophenyl)ethoxy]-2-methylpyridin-3-yl}-N-ethyl-N-methylimino Formamide, (A078) N'-{5-bromo-6-[(cis-4-isopropylcyclohexyl)oxy]-2-methylpyridin-3-yl}-N-ethyl- N-methyliminocarbamide, (A079) N'-{5-bromo-6-[(trans-4-isopropylcyclohexyl)oxy]-2-methylpyridin-3-yl} -N-ethyl-N methyl methylene Carbamethamide, (A080) N'-{5-bromo-6-[1-(3,5-difluorophenyl)ethoxy]-2-methylpyridin-3-yl}N-ethyl -N-Methyliminomethanamide, (A081) Mefenfluconazole, (A082) Clofluconazole, (A083) 1-(2,4-Difluorophenyl)-2-(1H- 1,2,4-Triazol-1-yl)-1-[1-(2,6-Difluoro-4-chlorophenoxy)cyclopropyl]ethanol, (A084) 1-[2-(l -Chlorocyclopropyl)-3-(2-fluorophenyl)-2-hydroxypropyl]-1H-imidazole-5-carbonitrile; (B) Respiratory chain complex I or II inhibitor, for example, (B001) Benzenefluconazole, (B002) Bixafen, (B003) Picosastrobin, (B004) Versiprofen, (B005) Fluopyram, (B006) Fluoxamide, (B007) Fluconazamide, (B008) Furopyram, (B009) Prothiosamide, (B010) Pyraclostrobin (anti-epimer 1R, 4S, 9S), (B011) Pyrazole Pyramid (anti-epimer 1S, 4R, 9R), (B012) Pyraclostrobin (anti-epimer 1RS, 4SR, 9SR), (B013) Pyraclostrobin ( Mixture of isomeric racemates 1RS, 4SR, 9RS and anti-epimeric racemates 1RS, 4SR, 9SR), (B014) Pyrazonamid (epimer 1R, 4S, 9R) ), (B015) Pyraclostrobin (epimers 1S, 4R, 9S), (B016) Pyraclostrobin (racemates 1RS, 4SR, 9RS), (B017) Fluconazole, (B018) Penthiozamide, (B019) Fluconazole hydroxylamine, (B020) Succinate dehydrogenase inhibitor, (B021) Fluconazole, (B022) 1,3-di Methyl-N-(1,1,3-trimethyl-2,3-dihydro-lH-inden-4-yl)-lH-pyrazole-4-carboxamide, (B023) 1,3- Dimethyl-N-[(3R)-1,l,3-trimethyl-2,3-dihydro-1H-inden-4-yl]-1H-pyrazole-4-carboxamide, (B024 ) 1,3-Dimethyl-N-[(3S)-1,1,3-trimethyl-2,3-dihydro-lH-inden-4-yl]-1H-pyrazole-4-methyl Amide, (B025) 1-methyl-3-(trifluoromethyl)-N-[2'-(trifluoromethyl)biphenyl-2-yl]-1H-pyrazole-4-methan Amine, (B026) 2-fluoro-6-(trifluoromethyl)-N-(1,1,3-trimethyl-2,3-dihydro-1H-inden-4-yl)benzamide , (B027) 3-(Difluoromethyl)-1-methyl-N-(1,1,3-trimethyl-2,3-dihydro-1H-inden-4-yl)-lH Pyrazole-4-carboxamide, (B028) 3-(difluoromethyl)-1-methyl-N-[(3R)-1,1,3-trimethyl-2,3-dihydro- lH inden-4-yl]-lH-pyrazole-4-carboxamide (sulfluramid), (B029) 3-(difluoromethyl)-1-methyl-N-[(3S)-1, 1,3-Trimethyl-2,3-dihydro-lH-inden-4-yl]-lH-pyrazole-4-carboxamide, (B030) 3-(difluoromethyl)-N-( 7-Fluoro-1,1,3-trimethyl-2,3-dihydro-lH-inden-4-yl)-1-methyl-1H-pyrazole-4-carboxamide (fluinconazole Amine), (B031) 3- (difluoromethyl)-N-[(3R)-7-fluoro-1,1,3-trimethyl-2,3-dihydro-1H-inden-4-yl ]-1-Methyl-1H-pyrazole-4-carboxamide, (B032) 3-(difluoromethyl)-N-[(3S)-7-fluoro-1,1,3-trimethyl -2,3-Dihydro-1H-inden-4-yl]-1-methyl-1H-pyrazole-4-carboxamide, (B033) 5,8-difluoro-N-[2-(2 -Fluoro-4-{[4-(trifluoromethyl)pyridin-2-yl]oxy}phenyl)ethyl]quinazolin-4-amine, (B034) N-(2-cyclopentyl- 5-fluorobenzyl)-N-cyclopropyl-3-(difluoromethyl)-5-fluoro-1-methyl-1H-pyrazole-4-carboxamide, (B035) N-(2- Tert-Butyl-5-methylbenzyl)-N-cyclopropyl-3-(difluoromethyl)-5-fluoro-1-methyl-1Hpyrazole-4-carboxamide, (B036) N -(2-tert-butylbenzyl)-N-cyclopropyl-3-(difluoromethyl)-5-fluoro-1-methyl-1H-pyrazole-4-carboxamide, (B037) N -(5-Chloro-2-ethylbenzyl)-N-cyclopropyl-3-(difluoromethyl)-5-fluoro-1-methyl-1H-pyrazole-4-carboxamide, ( B038) N-(5-Chloro-2-isopropylbenzyl)-N-cyclopropyl-3-(difluoromethyl)-5-fluoro-1-methyl-1H-pyrazole-4-methyl Amide, (B039) N-[(1R,4S)-9-(dichloromethylene)-1,2,3,4-tetrahydro-1,4-methylenenaphthalene-5-yl]-3 -(Difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide, (B040) N-[(1S,4R)-9-(dichloromethylene)-1,2, 3,4-Tetrahydro-1,4-methylenenaphthalene-5-yl]-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide, (B041) N- [1-(2,4-Difluorophenyl)-1-methoxypropan-2-yl]-3-(difluoromethyl)-1-methyl 1H-pyrazole-4-carboxamide, (B042) N-(2-Chloro-6-(trifluoromethyl)benzyl)-N-cyclopropyl-3-(difluoromethyl)-5-fluoro-1-methyl-1H-pyrazole -4-methylamide, (B0 43) N-[3-Chloro-2-fluoro-6-(trifluoromethyl)benzyl]-N-cyclopropyl-3-(difluoromethyl)-5-fluoro-1-methyl-1H -Pyrazole-4-carboxamide, (B044) N-[5-chloro-2-(trifluoromethyl)benzyl]-N-cyclopropyl-3-(difluoromethyl)-5-fluoro -1-Methyl-1H-pyrazole-4-carboxamide, (B045) N-cyclopropyl-3-(difluoromethyl)-5-fluoro-1-methyl-N-[5-methyl 2-(trifluoromethyl)benzyl]-1H-pyrazole-4-carboxamide, (B046) N-cyclopropyl-3-(difluoromethyl)-5-fluoro-N-( 2-Fluoro-6-isopropylbenzyl)-1-methyl-1H-pyrazole-4-carboxamide, (B047) N-cyclopropyl-3-(difluoromethyl)-5-fluoro -N-(2-isopropyl-5-methylbenzyl)-1-methyl-1H pyrazole-4-carboxamide, (B048) N-cyclopropyl-3-(difluoromethyl) -5-fluoro-N-(2-isopropylbenzyl)-1-methyl-IH-pyrazole-4-thioamide, (B049) N-cyclopropyl-3-(difluoromethyl )-5-fluoro-N-(2-isopropylbenzyl)-1-methyl-1H-pyrazole-4-carboxamide, (B050) N-cyclopropyl-3-(difluoromethyl )-5-fluoro-N-(5-fluoro-2-isopropylbenzyl)-1-methyl-1H-pyrazole-4-carboxamide, (B051) N-cyclopropyl-3-( Difluoromethyl)-N-(2-ethyl-4,5-dimethylbenzyl)-5-fluoro-1-methyl-1H-pyrazole-4-carboxamide, (B052) N- Cyclopropyl-3-(difluoromethyl)-N-(2-ethyl-5-fluorobenzyl)-5-fluoro-1-methyl-1H-pyrazole-4-carboxamide, (B053 ) N-Cyclopropyl-3-(difluoromethyl)-N-(2-ethyl-5-methylbenzyl)-5-fluoro-1-methyl-1H-pyrazole-4-methan Amine, (B054) N-cyclopropyl-N-(2-cyclopropyl-5-fluorobenzyl)-3-(difluoromethyl)-5-fluoro-1-methyl-1H-pyrazole- 4-formamide, (B055) N-cyclopropyl-N-(2-cyclopropyl-5-methylbenzyl)-3-(difluoromethyl)-5-fluoro-1-methyl- 1H-pyrazole-4-carboxamide, (B056) N-cyclopropyl-N-(2-cyclopropylbenzyl)-3-(difluoromethyl)-5-fluoro-1-methyl- 1H-pyrazole-4-carboxamide, (B057) 2-(difluoromethyl)-N-(l,1-dimethyl-3-propyl-2,3-dihydro-1H-indene- 4-yl) Niacinamide, (B058) Pyrazolamide; (C) Respiratory chain complex III inhibitors, for example, (C001) pyraclostrobin, (C002) indazolamide, (C003) nitrile Azoxystrobin, (C004) methstrobin, (C005) syringostrobin, (C006) cyfamidazole, (C007) ketostrobin, ( C008) Entristrobin, (C009) oxaclostrobin, (C010) Fidaclostrobin, (C011) Fluoxystrobin, (C012) Fluoxastrobin, (C013) Kresoxim-methyl, (C014) Phenoxy Strobil, (C015) orysastrobin, (C016) picoxystrobin, (C017) pyraclostrobin, (C018) pyraclostrobin, (C019) pyraclostrobin, (C020) trifloxystrobin, ( C021)(2E)-2-{2-[({[(1E)-1-(3-{[(E)-1-fluoro-2-phenylvinyl]oxy} phenyl)ethylene ]Amino}oxy)methyl]phenyl}-2-(methoxyimino)-N-methylacetamide, (C022) (2E,3Z)-5-{[1-(4-fluoro Phenyl)-lH-pyrazol-3-yl]oxy)-2-(methoxyimino)-N,3-dimethylpentyl-3-enamine, (C023) (2R)-2 -{2-[(2,5-Dimethylphenoxy)methyl]phenyl}-2-methoxy-N-methylacetamide, (C024) (2S)-2-{2- [(2,5-Dimethylphenoxy)methyl]phenyl}-2-methoxy-N-methylacetamide, (C025) (3S,6S,7R,8R)-8-benzyl Group-3-[({3-[(isobutyroxy)methoxy]-4-methoxypyridin-2-yl}carbonyl)amino]-6-methyl-4,9-dioxo- Methyl 1,5-dioxolane-7-yl-2-propionate (Benzoxamid), (C026) 2-{2-[(2,5-dimethylphenoxy)methyl] Phenyl}-2-methoxy-N-methylacetamide (Methoxyacrylate fungicide), (C027) N-(3-ethyl-3,5,5-trimethylcyclohexyl )-3-Formamide-2-hydroxybenzamide, (C028) (2E,3Z)-5-{[1-(4-chloro-2-fluorophenyl)-lH-pyrazole-3- Yl]oxy}-2-(methoxyimino)-N,3-dimethylpentyl-3-enamine, (C029) methyl{5-[3-(2,4-dimethyl Phenyl)-lH-pyrazol-1-yl]-2-methylbenzyl}carbamate, (C030) 1-(2-{[1-(4-fluorophenyl)pyrazole-3- Yl]oxymethyl}-3-methylphenyl)-1,4-dihydro-4-methyl-5H-tetrazol-5-one (benylpyrazole), (C031) pyridine amides Fungicides; (E) Compounds with multiple actions, such as (E001) Bordeaux mixture, (E002) Dicaptan, (E003) Captan, (E004) Chlorothalonil, (E005) Copper hydroxide, (E006) ) Copper Naphthenate, (E007) Copper Oxide, (E008) Copper Oxychloride, (E009) Copper Sulfate (2+), (E010) Dithianon, (E011) Dorbutin, (E012) Sanitizer, ( E013) generation Mancozeb, (E014) Mancozeb, (E015) Mancob, (E016) Zinc, (E017) Copper quinoline, (E018) Zinc methyl, (E019) Sulfur and sulfur preparations, Including calcium polysulfide, (E020) thiram, (E021) zymogen, (E022) thiram, (E023) 6-ethyl-5,7-diox-6,7-dihydro-5H pyrrolo[ 3',4':5,6][1,4]Dithianon[2,3-c][1,2]thiazole-3-carbonitrile; (L) (L003) metalaxyl, (L004) formaldehyde Trixyl-M (Metalaxyl), (M) (M001) Fludioxonil, (M002) Iprodione, (M004) Propoxyquin, (M005) Quinoxaline, (N) (N001) Fluorine Pyridamine, (N002) anti-mites, (O) other compounds, such as (O001) abscisic acid, (O002) thiocyanate, (O003) benzoxazine, (O004) carbamicin, (O005) fragrance Pyrrolidone, (O006) mitrate, (O007) thiazolene, (O008) cyfluranil, (O009) cymoxanil, (O010) cyprofenamide, (O011) flutinib, (O012) ) Aluminum Triethylphosphonate, (O013) Calcium Triethylphosphonate, (O014) Sodium, (O015) Methyl Isothiocyanate, (O016) Benzophenone, (O017) Midomycin, (O018) Natamycin, (O019) nickel thiram, (O020) phthalotrobin, (O021) oxacarb, (O022) fluthiazol, (O023) oxphenthiol, (O024) pentachlorophenol and salt , (O025) Phosphoric acid and its salts, (O026) Proboscis fodronate, (O027) Methoxylin (Chlozone), (O028) Isobutyl Ethoxyquin, (O029) Leaf Blight Phthalide, (O030) Messulfan, (O031) 1-(4-{4-[(5R)-5-(2,6-Difluorophenyl)-4,5-dihydro-1,2- Oxazol-3-yl]-1,3-thiazol-2-yl}piridin-1-yl)-2-[5-methyl-3-(trifluoromethyl)-1H-pyrazole-1- Base] ethyl ketone, (O032) 1-(4-{4-[(5S)-5-(2,6-difluorophenyl)-4,5-dihydro-l,2-oxazole-3- Yl]-l,3-thiazol-2-yl}piridin-1-yl)-2-[5-methyl-3-(trifluoromethyl)-1H-pyrazole-1-yl]ethanone, (0033) 2-(6-benzylpyridin-2-yl)quinazoline, (0034) 2,6-dimethyl-1H,5H-[1,4]dithianon[2,3-c: 5,6-c']Dipyrrole-1,3,5,7(2H,6H)-tetraketone, (O035) 2-[3,5-bis(difluoromethyl)-lH-pyrazole -1-yl]-1-[4-(4-{5-[2-(propyl-2-yn-1-yloxy)phenyl]-4,5-dihydro-l,2-oxa Azol-3-yl}-l,3-thiazol-2-yl)piridin-1-yl]ethanone, (O036) 2-[3,5-bis(difluoromethyl)-1H-pyrazole- 1-yl]-1-[4-(4-{5-[2-chloro-6-(propyl-2-yn-1-yloxy)phenyl]-4,5-dihydro-1, 2-oxazol-3-yl}-1,3-thiazol-2-yl)piridin-1-yl]ethanone, (O037) 2-[3,5-bis(difluoromethyl)-lH- Pyrazol-1-yl]-1-[4-(4-{5-[2-Fluoro-6-(propyl-2-yn-1-yloxy)phenyl]-4,5-dihydro -1,2-oxazol-3-yl}-l,3-thiazol-2-yl)piridin-1-yl]ethanone, (O038) 2-[6-(3-fluoro-4-methoxy Phenyl)-5-methylpyridin-2-yl]quinazoline, (O039) 2-{(5R)-3-[2-(1-{[3,5-bis(difluoromethyl) -lH-Pyrazol-1-yl]acetin-4-yl)-1,3-thiazol-4-yl]-4,5-dihydro-l,2-oxazol-5-yl }-3-fluorophenyl methanesulfonate, (O040) 2-{(5S)-3-[2-(1-{[3,5-bis(difluoromethyl)-1H-pyrazole-1 -Yl]acetinyl)piridin-4-yl)-1,3-thiazol-4-yl]-4,5-dihydro-1,2-oxazol-5-yl)-3-fluorophenyl Methanesulfonate, (O041) 2-{2-[(7,8-Difluoro-2-methylquinolin-3-yl)oxy]-6-fluorophenyl}propane-2-ol, ( O042) 2-{2-fluoro-6-[(8-fluoro-2-methylquinolin-3-yl)oxy]phenyl}propane-2-ol, (O043) 2-{3-[2 -(1-{[3,5-Bis(difluoromethyl)-1H-pyrazol-1-yl]acetyl}piridin-4-yl)-1,3-thiazol-4-yl]- 4,5-Dihydro-1,2-oxazol-5-yl}-3-fluorophenyl methanesulfonate (Bayer "wonder" fungicide), (O045) 2-phenylphenol and salt, (O046 ) 3-(4,4,5-trifluoro-3,3-dimethyl-3,4-dihydroisoquinolin-1-yl)quinoline, (O047) 3-(4,4-difluoro -3,3-Dimethyl-3,4-dihydroisoquinolin-1-yl)quinoline (quinoline fungicides), (O048) 4-amino-5-fluoropyrimidin-2-ol (reciprocal Transmers: 4-amino-5-fluoropyrimidine-2(1H)-one), (O049) 4-oxo-4-[(2-phenylethyl)amino]butanoic acid, (O050) 5- Amino-1,3,4-thiadiazole-2-thiol, (O051) 5-chloro-N'-phenyl-N'-(propyl-2-yn-1-yl)thiophene-2-sulfon Hydrazine, (O052 ) 5-fluoro-2-[(4-fluorobenzyl)oxy]pyrimidin-4-amine, (O053) 5-fluoro-2-[(4-methylbenzyl)oxy]pyrimidin-4-amine , (O054) 9-Fluoro-2,2-dimethyl-5-(quinolin-3-yl)-2,3-dihydro-1,4-phenoxazapine, (O055) but-3- Alkyn-1-yl{6-[({[(Z)-(l-methyl-1H-tetrazol-5-yl)(phenyl)methylene]amino}oxy)methyl]pyridine-2 -Yl}carbamate, (O056) ethyl (2Z)-3-amino-2-cyano-3-phenyl acrylate, (O057) phenazine-1-carboxylic acid, (O058) propyl 3, 4,5-Trihydroxybenzyl, (O059) quinoline-8-ol, (O060) quinoline-8-ol sulfate (2:1), (O061) tert-butyl {6-[({[ (1-Methyl-1H-tetrazol-5-yl)(phenyl)methylene]amino}oxy)methyl]pyridin-2-yl}carbamate, (O062) 5-fluoro-4 -Imino-3-methyl-1-[(4-methylphenyl)sulfonyl]-3,4-dihydropyrimidine-2(1H)-one, (O063) pyridine chloromethyl, (O064 ) Isoflurane, (O065) broad-spectrum pyridine fungicides, (P) histone deacetylase inhibitors, such as (P001) N-(1-ethylcyclopropyl)-4-[5 -(Trifluoromethyl)-1,2,4-oxadiazol-3-yl]benzamide; (P002) N-(2-isopropylcyclopropyl)-4-[5-(tri Fluoromethyl)-1,2,4-oxadiazol-3-yl]benzamide; (P003) N-(2-methylcyclopropyl)-4-[5-(trifluoromethyl) -1,2,4-oxadiazol-3-yl]benzamide; (P004) N-(1-methylcyclopropyl)-4-[5-(trifluoromethyl)-1,2 ,4-oxadiazol-3-yl]benzamide; (P005) N-(2-ethylcyclopropyl)-4-[5-(trifluoromethyl)-1,2,4-oxa Diazol-3-yl]benzamide; (P006) N-(2,4-difluorophenyl)-4-[5-(trifluoromethyl)-1,2,4-oxadiazole- 3-yl]benzamide; (P007) 5-(trifluoromethyl)-3-[4-[[3-(trifluoromethyl)-1,2,4triazol-1-yl]methyl] Phenyl]-1,2,4-oxadiazole; (P008) 2-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl] Methyl]-1,2,4-triazole-3-carbonitrile; (P009) ethyl 1-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazole-3- Yl]phenyl]methyl]pyrazole-4-carboxylate; (P010) N-cyclopropyl-1-[[4-[5-(trifluoromethyl)-1,2,4-oxa Azol-3-yl]phenyl]methyl]pyrazole-4-carboxamide; (P011) N,N-dimethyl-1-[(4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)phenyl)methyl)pyrazole- 4-formamide; (P012) N-methyl-1-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl] Pyrazole-4-carboxamide; (P013) N,N,-dimethyl-H[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]benzene Group]Methyl]-1,2,4-triazol-3-amine; (P014) 3-[4-[(5-ethylsulfonyl-1,2,4-triazol-1-yl) Methyl]phenyl]-5-(trifluoromethyl)-1,2,4-oxadiazole; (P015) 3-[4-(triazole[4,5-b]pyridin-1-ylmethyl Yl)phenyl]-5-(trifluoromethyl)-1,2,4-oxadiazole; (P016) 3-[4-(triazole[4,5-b]pyridin-2-ylmethyl )Phenyl]-5-(trifluoromethyl)-1,2,4-oxadiazole; (P017) 3-[4-(triazole[4,5-b]pyridin-3-ylmethyl) Phenyl]-5-(trifluoromethyl)-1,2,4-oxadiazole; (P018) methyl 1-[[4-[5-(trifluoromethyl)-1,2,4- Oxadiazol-3-yl]phenyl]methyl]pyrazole-4-carboxylate; (P019) ethyl 1-[[3-fluoro-4-[5-(trifluoromethyl)-1, 2,4-oxadiazol-3-yl]phenyl]methyl]pyrazole-4-carboxylate; (P020) N,N -diethyl-1-[[4-[5-(trifluoro (Methyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]pyrazole-4-carboxamide; (P021) N -methoxy- N -methyl-1-[ [4-[5-(Trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]pyrazole-4-carboxamide; (P022) propyl 1-[ [4-[5-(Trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]pyrazole-4-carboxylate; (P023) N -methoxy -1-[[4-[5-(Trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]pyrazole-4-carboxamide; (P024) N -Ethyl-1-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]pyrazole-4-carboxamide; ( P025) 1-[[4-[5-(Trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]pyrazole-4-carboxamide; (P026) N -Methoxy-1-[1-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]pyrazole-4- Group] imine; (P027) ethyl 1-[1-[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]ethyl]pyrazole -4-carboxylate; (P028) 1-[[4-[5 -(Trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]pyrrolidin-2-one; (P029) 1-[[4-[5-(Trifluoro Methyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]piridin-2-one; (P030) 4-[[4-[5-(trifluoromethyl)- 1,2,4-oxadiazol-3-yl]phenyl]methyl]morpholin-3-one; (P031) 4,4-dimethyl-2-[[4-[5-(trifluoro Methyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]isoxazolin-3-one; (P032) 2-[[4-[5-(trifluoromethyl) )-1,2,4-oxadiazol-3-yl]phenyl]methyl]isoxazolin-3-one; (P033) 5,5-dimethyl-2-[[4-[5 -(Trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]isoxazolin-3-one; (P034) 3,3-dimethyl-1- [[4-[5-(Trifluoromethyl)-1 ,2,4-oxadiazol-3-yl]phenyl]methyl]piridin-2-one; (P035) 1-[[2- Fluoro-4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]pyrrolidin-2-one; (P036) 1-[[2- Fluoro-4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]piridin-2-one; (P037) 2-[[4- [5-(Trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]oxazin-3-one; (P038) 1-[[3-fluoro-4- [5-(Trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]piridin-2-one; (P039) 3-[[4-[5-( Trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]oxazolidine-2-one; (P040) 1-methyl-3-[[4-[5- (Trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]imidazolin-2-one; (P041) 1-[[3-Fluoro-4-[5 -(Trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]-3,3-dimethyl-pyridin-2-one; (P042) 1-[ [3-Fluoro-4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]pyrrolidin-2-one; (P043) 2-[ [3-Fluoro-4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]-4,4-dimethyl-isoxazoline -3-one; (P044) 2-[[2,3-difluoro-4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl ]Isoxazolin-3-one; (P045) 2-[[3-fluoro-4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl] Methyl]isoxazolin-3-one; (P046) 1-[[3-fluoro -4-[5-(Trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]azaalan-2-one; (P047) N-[[4- [5-(Trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]propanamide; (P048) 2,2-dimethyl-N-[[4 -[5-(Trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]butyl-3-ynamide; (P049) N-[[4-[ 5-(Trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]butyramide; (P050) 3-methyl-N-[[4-[5- (Trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]butyramide; (P051) 2-methyl-N-[[4-[5-(三Fluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]propyl-2-enamine; (P052) 2-methyl-N-[[4-[5- (Trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]butyramide; (P053) 2-methoxy-N-[[4-[5-( Trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]; (P054) 3,3,3-trifluoro-N-[[3-fluoro-4-[ 5-(Trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]propanamide; (P055) 3,3,3-trifluoro-N-[[2 -Fluoro-4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]propanamide; (P056) N-[[2,3- Difluoro-4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]butyramide; (P057) N-[[2,3- Difluoro-4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]-3,3,3-trifluoro-propanamide; P058) 2-(Difluoromethoxy)-N-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl)methyl)acetate Amine; (P059) 2-methoxy-2-methyl-N-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methan Yl]propanamide; (P060) 1-methyl-3-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl] Urea; (P061) 1-ethyl-1-methyl-3-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl ] Urea; (P062) 1-ethoxy-3-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]urea; (P063) 1-Methoxy-1-methyl-3-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)phenyl)methyl) Urea; (P064) 1,1-diethyl-3-[[4-[5-(trifluoromethyl) -1 ,2,4-oxadiazol-3-yl]phenyl]methyl]urea; (P065) N-methoxy-N-[[4-[5-(trifluoromethyl)-1, 2,4-oxadiazol-3-yl]phenyl]methyl]cyclopropanecarboxamide; (P066) N-methoxy-N-[[4-[5-(trifluoromethyl)-1 ,2,4-oxadiazol-3-yl]phenyl]methyl]pentyl-4-ynamide; (P067) N-methoxy-2-methyl-N-[[4-[5 -(Trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl)propyl-2-enamine; (P068) N,2-Dimethoxy-N- [[4-[5-(Trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]propionamide; (P069) N-cyclopropyl-3,3 ,3-Trifluoro-N-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]propanamide; (P070) 2 ,2-Difluoro-N-(2-methoxyethyl)-N-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl ]Methyl]cyclopropanecarboxamide; (P071) N-ethyl-2-methyl-N-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazole-3 -Yl]phenyl]methyl]propanamide; (P072) N-[[3-fluoro-4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl] Phenyl]methyl]-N-methoxy-propanamide; (P073) 2-methoxy-N-(2,2,2-trifluoroethyl)-N-[[4-[5- (Trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]acetamide; (P074) N-[[2,3-difluoro-4-[5- (Trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl)-N-methoxy-cyclopropanecarboxamide; (P075) 2-(difluoromethoxy Yl)-N-methyl-N-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]acetamide; (P076 ) N-ethoxy-2-methoxy-N-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]propane Amide; (P077) N-isopropyl-N-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]tetrahydrofuran- 2-Formamide; (P078) 1-methoxy-3-methyl-1-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl] Phenyl]methyl]urea; (P079) 3-cyclopropyl-1-methoxy-1-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazole-3 -Yl]phenyl]methyl]urea; (P080) 3-ethoxy-1-methoxy-1-[[4-[5-(trifluoromethyl)-1,2,4-oxa Azol-3-yl]phenyl]methyl]urea; (P081) 3-allyl-1 -Methoxy-1-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]urea; (P082) 1-cyclopropyl 3-methoxy-3-methyl-1-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]urea ;(P083) 3-isopropyl-1-methoxy-1-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methan Yl]urea; (P084) 1-methoxy-3-propyl-2-ynyl-1-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazole-3 -Yl]phenyl]methyl]urea; (P085) 1-[[3-fluoro-4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl ]Methyl]-1-methoxy-3-methyl-urea; (P086) 3-(cyclopropylmethyl)-1-methyl-1-[[4-[5-(trifluoromethyl )-1,2,4-oxadiazol-3-yl]phenyl]methyl]urea; (P087) 1-ethyl-3-(2,2,2-trifluoroethyl)-1-[ [4-[5-(Trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]urea; (P088) 1,3-dimethoxy-1-[ [4-[5-(Trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]urea; (P089) 3-ethyl-1-methoxy-1 -[[4-[5-(Trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]urea; (P090) N-methyl-4-[5- (Trifluoromethyl)-1,2,4-oxadiazol-3-yl]benzamide; (P091) N-[(E)-methoxyiminomethyl]-4-[5- (Trifluoromethyl)-1,2,4-oxadiazol-3-yl]benzamide; (P092) N-[(Z)-methoxyiminomethyl]-4-[5- (Trifluoromethyl)-1,2,4-oxadiazol-3-yl]benzamide; (P093) N-[4-[5-(trifluoromethyl)-1,2,4- Oxadiazol-3-yl]phenyl]cyclopropanecarboxamide; (P094) N-(2-fluorophenyl)-4-[5-(trifluoromethyl)-1,2,4-oxa Azol-3-yl]benzamide; (P095) 2,2-difluoro-N-methyl-2-[4-[5-(trifluoromethyl)-1,2,4-oxadiazole -3-yl]phenyl]acetamide; (P096) N-allyl-N-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl ]Phenyl]methyl]acetamide; (P097) N-[(E)-N-methoxy-C-methyl-carbimino]-4-[5-(trifluoromethyl)-1 ,2,4-oxadiazol-3-yl]benzamide; (P098) N-[(Z)-N-methoxy-C-methyl-carbimino]-4-[5-( (Trifluoromethyl)-1,2,4-oxadiazol-3-yl]benzamide; ( P100) N-allyl-N-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]propanamide; (P101 ) 4,4-Dimethyl-1-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]pyrrolidine-2- Ketone; (P102) N-methyl-4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]benzylthioamide; (P104) N-methyl- 4-[5-(Trifluoromethyl)-1,2,4-oxadiazol-3-yl]benzamide; (P104) N1-methyl-N2-(4-(5-(三(Fluoromethyl)-1,2,4-oxadiazol-3-yl)benzyl) glufamide. (Q) Q001) 1-(2,4-Difluorophenyl)-5-(ethoxycarbonyl)-5-methyl-2-pyrazoline-3-carboxylic acid, (Q002) ethyl 1- (2,4-Difluorophenyl)-5-(ethoxycarbonyl)-5-methyl-2-pyrazoline-3-carboxylate ("pyrazolone (-diethyl)" ).
本發明的化合物(I)的還更優選的組合物包括（2）至少一種下列活性化合物： (A001) 環丙唑醇，(A002) 苯醚甲環唑，(A003) 氟環唑，(A006) 丁苯嗎啉，(A009) 粉唑醇，(A012) 種菌唑，(A013) 葉菌唑，(A017) 丙環唑，(A018) 丙硫菌唑，(A021) 戊唑醇，(A022) 氟醚唑，(A081) 甲芬氟康唑，(A082) 氯氟醚菌唑，(B001) 苯並烯氟菌唑，(B002) 聯苯吡菌胺，(B003) 啶醯菌胺，(B005) 氟吡菌醯胺，(B007) 氟唑菌醯胺，(B009) 異丙噻菌胺，(B010) 吡唑萘菌胺 (B017) 氟唑菌苯胺，(B018) 吡噻菌胺，(B019) 氟唑菌醯羥胺，(B.021) 氟唑環菌胺，(B028) 氟蟲胺，(B030) 3-(二氟甲基)-N-(7-氟-1,1,3-三甲基-2,3-二氫-lH-茚-4-基)-1-甲基-1H-吡唑-4-甲醯胺 (氟茚唑菌胺)，(C003) 腈嘧菌酯，(C007) 醚菌胺，(C012) 氟嘧菌酯，(C013) 醚菌酯，(C014) 苯氧菌胺，(C016) 啶氧菌酯，(C017) 唑菌胺酯，(C020) 肟菌酯，(C025) (3S,6S,7R,8R)-8-苄基-3-[({3-[(異丁醯氧基)甲氧基]-4-甲氧基吡啶-2-基}羰基)氨基]-6-甲基-4,9-二氧-1l,5-二惡茂烷-7-基-2-丙酸甲酯 (苯呱沙米)，(C031) 吡啶醯胺類殺菌劑， (D001) 多菌靈，(D007) 甲基硫菌靈 (D012) 4-(2-溴-4-氟苯基)-N-(2,6-二氟苯基)-1,3-二甲基-1 H-吡唑-5-胺，(D015) 4-(2-溴-4-氟苯基)-N-(2-氯-6-氟苯基)-1,3-二甲基-1 H-吡唑-5-胺，(D025) N-(4-氯-2,6-二氟苯基)-4-(2-氯-4-氟苯基)-1,3-二甲基-lH-吡唑-5-胺， (E003) 克菌丹，(E004) 百菌清，(E010) 二噻農，(E012) 滅菌丹，(E013) 代森錳鋅，(E015) 代森聯，(E018) 甲基代森鋅，(E020) 福美雙， (L003) 甲霜靈，(L004) 甲霜靈-M (精甲霜靈)， (M001) 咯菌腈，(M002) 異菌脲，(M004) 丙氧喹啉，(M005) 喹氧靈， (N001) 氟啶胺，(N002) 消蟎多， (O008) 環氟菌胺，(15.010) 環丙磺醯胺，(O011) 氟替尼，(O012) 三乙膦酸鋁，(15.016) 苯菌酮，(O022) 氟噻唑吡乙酮，(O027) 甲氧苯唳菌(氯氮酮)，(O043) 2-{3-[2-(1-{[3,5-雙(二氟甲基)-1H-吡唑-1-基]乙醯基}呱啶-4-基)-1,3-噻唑-4-基]-4,5-二氫-1,2-惡唑-5-基}-3-氟苯基 甲磺酸鹽 (拜耳“奇葩”殺菌劑)，(O047) 3-(4,4-二氟-3,3-二甲基-3,4-二氫異喹啉-1-基)喹啉 (喹啉類殺菌劑)，(O048) 4-氨基-5-氟嘧啶-2-醇 (互變異構體: 4-氨基-5-氟嘧啶-2(1H)-酮)，(O052) 5-氟-2-[(4-氟苄基)氧基]嘧啶-4-胺，(O053) 5-氟-2-[(4-甲基苄基)氧基 ]嘧啶-4-胺，(O062) 5-氟-4-亞氨基-3-甲基-1-[(4-甲基苯基)磺醯基]-3,4-二氫嘧啶-2(1H)-酮，(O063) 吡啶氯甲基，(O064) 異氟苯諾喹，(O065) 廣譜吡啶類殺菌劑， (P006) N-(2,4-二氟苯基)-4-[5-(三氟甲基)-1,2,4-惡二唑-3-基]苯甲醯胺，(P104) N-甲基-4-[5-(三氟甲基)-1,2,4-惡二唑-3-基]苯甲甲醯胺。A still more preferred composition of the compound (I) of the present invention includes (2) at least one of the following active compounds: (A001) ciproconazole, (A002) difenoconazole, (A003) epoxiconazole, (A006) bufenoline, (A009) fluconazole, (A012) conazole, (A013) leaf fungus Azole, (A017) propiconazole, (A018) prothioconazole, (A021) tebuconazole, (A022) flufenconazole, (A081) mefenfluconazole, (A082) fluconazole, ( B01 Pyraclostrobin, (B010) Pyraclostrobin (B017) Pyraclostrobin, (B018) Pyraclostrobin, (B019) Pyraclostrobin, (B.021) Pyraclostrobin, (B028) Sulfluramid, (B030) 3-(difluoromethyl)-N-(7-fluoro-1,1,3-trimethyl-2,3-dihydro-lH-inden-4-yl)-1 -Methyl-1H-pyrazole-4-carboxamide (fluinconazole), (C003) azoxystrobin, (C007) azoxystrobin, (C012) fluoxastrobin, (C013) oxystrobin Esters, (C014) phenoxystrobin, (C016) picoxystrobin, (C017) pyraclostrobin, (C020) trifloxystrobin, (C025) (3S,6S,7R,8R)-8-benzyl -3-[({3-[(isobutyroxy)methoxy]-4-methoxypyridin-2-yl}carbonyl)amino]-6-methyl-4,9-diox-1l , 5-Dioxolane-7-yl-2-propionic acid methyl ester (Benzoxamem), (C031) pyridine amide fungicide, (D001) Carbendazim, (D007) Thiophanate-methyl (D012) 4-(2-bromo-4-fluorophenyl)-N-(2,6-difluorophenyl)-1,3-di Methyl-1 H-pyrazole-5-amine, (D015) 4-(2-bromo-4-fluorophenyl)-N-(2-chloro-6-fluorophenyl)-1,3-dimethyl Base-1 H-pyrazol-5-amine, (D025) N-(4-chloro-2,6-difluorophenyl)-4-(2-chloro-4-fluorophenyl)-1,3- Dimethyl-lH-pyrazol-5-amine, (E003) Captan, (E004) Chlorothalonil, (E010) Dithianon, (E012) Dixon, (E013) Mancozeb, (E015) Mancozeb, (E018) Zinc methyl , (E020) Fumei Shuang, (L003) Metalaxyl, (L004) Metalaxyl-M (Metalaxyl), (M001) Fludioxonil, (M002) Iprodione, (M004) Proquinoline, (M005) Quinoxaline, (N001) Fluazinam, (N002) Anti-mites, (0008) cyfluxanil, (15.010) cyprofenamide, (O011) flutinib, (O012) aluminum triethyl phosphonate, (15.016) benzophenone, (O022) fluthiazole pyroxenone, ( O027) Methoxybens (chlorazone), (O043) 2-{3-[2-(1-{[3,5-bis(difluoromethyl)-1H-pyrazol-1-yl] Acetyl}piridin-4-yl)-1,3-thiazol-4-yl)-4,5-dihydro-1,2-oxazol-5-yl}-3-fluorophenylmethanesulfonic acid Salt (Bayer "wonderful" fungicide), (O047) 3-(4,4-difluoro-3,3-dimethyl-3,4-dihydroisoquinolin-1-yl)quinoline (quinoline Fungicides), (O048) 4-amino-5-fluoropyrimidin-2-ol (tautomer: 4-amino-5-fluoropyrimidine-2(1H)-one), (O052) 5-fluoro- 2-[(4-Fluorobenzyl)oxy]pyrimidin-4-amine, (O053) 5-fluoro-2-[(4-methylbenzyl)oxy]pyrimidin-4-amine, (O062) 5 -Fluoro-4-imino-3-methyl-1-[(4-methylphenyl)sulfonyl]-3,4-dihydropyrimidine-2(1H)-one, (O063) pyridine chloromethyl Base, (O064) isoflurane, (O065) broad-spectrum pyridine fungicide, (P006) N-(2,4-Difluorophenyl)-4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]benzamide, (P104) N-Methyl-4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]benzamide.
本發明的化合物(I)的還更優選的組合物包括（2）至少一種下列活性化合物： (A001) 環丙唑醇，(A002) 苯醚甲環唑，(A004) 氟醚唑 (A006) 丁苯嗎啉，(A009) 粉唑醇，(A013) 葉菌唑，(A017) 丙環唑，(A018) 丙硫菌唑，(A021) 戊唑醇，(A022) 氟環唑，(A081) 甲芬氟康唑，(B001) 苯並烯氟菌唑，(B002) 聯苯吡菌胺，(B005) 氟吡菌醯胺，(B007) 氟唑菌醯胺，(B019) 氟唑菌醯羥胺，(B028) 氟蟲胺，(B30) 氟茚唑菌胺，(B038) 異氟普蘭，(C003) 腈嘧菌酯，(C012) 氟嘧菌酯 (C014) 苯氧菌胺，(C017) 唑菌胺酯，(C016) 啶氧菌酯，(C020) 肟菌酯，(C025) (3S,6S,7R,8R)-8-苄基-3-[({3-[(異丁醯氧基)甲氧基]-4-甲氧基吡啶-2-基}羰基)氨基]-6-甲基-4,9-二氧-1,5-二惡茂烷-7-基-2-丙酸甲酯 (苯呱沙米)，(C030) 1-(2-{[1-(4-氟苯基)吡唑-3-基]氧基甲基}-3-甲基苯基)-1,4-二氫-4-甲基-5H-四唑-5-酮 (本基吡唑)，(D001) 多菌靈，(D007) 甲基硫菌靈，(E004) 百菌清，(E010) 二噻農 ，(E013) 代森錳鋅，(E020) 福美雙，(L003) 甲霜靈，(M001) 咯菌腈，(N001) 氟啶胺，(O022) 氟噻唑吡乙酮，(O043) 2-{3-[2-(1-{[3,5-雙(二氟甲基)-1H-吡唑-1-基]乙醯基}呱啶-4-基)-1,3-噻唑-4-基]-4,5-二氫-1,2-惡唑-5-基}-3-氟苯基 甲磺酸鹽 (拜耳“奇葩”殺菌劑)，(O046) 3-(4,4,5-三氟-3,3-二甲基-3,4-二氫異喹啉-1-基)喹啉，(O047) 3-(4,4-二氟-3,3-二甲基-3,4-二氫異喹啉-1-基)喹啉 (喹啉類殺菌劑)，(O065) 異氟苯諾喹，(P006) N-(2,4-二氟苯基)-4-[5-(三氟甲基)-1,2,4-惡二唑-3-基]苯甲醯胺和(P103) 5-甲基-1-[[4-[5-(三氟甲基)-1,2,4-惡二唑-3-基]苯基]甲基]吡咯烷-2-酮。A still more preferred composition of the compound (I) of the present invention includes (2) at least one of the following active compounds: (A001) ciproconazole, (A002) difenoconazole, (A004) flufenconazole (A006) fenmorpholine, (A009) fluconazole, (A013) metconazole, (A017) propanol Azole, (A018) prothioconazole, (A021) tebuconazole, (A022) epoxiconazole, (A081) mefenfluconazole, (B001) benfluconazole, (B002) bixafen Amine, (B005) fluopyram, (B007) fluconazole, (B019) fluconazole hydroxylamine, (B028) sulfluramid, (B30) fluconazamide, (B038) isoflurane Propan, (C003) azoxystrobin, (C012) fluoxastrobin (C014) phenoxystrobin, (C017) pyraclostrobin, (C016) picoxystrobin, (C020) trifloxystrobin, (C025) ) (3S,6S,7R,8R)-8-benzyl-3-[({3-[(isobutyroxy)methoxy]-4-methoxypyridin-2-yl}carbonyl)amino ]-6-Methyl-4,9-dioxo-1,5-dioxolane-7-yl-2-propionic acid methyl ester (Benzamide), (C030) 1-(2-{[ 1-(4-Fluorophenyl)pyrazol-3-yl)oxymethyl)-3-methylphenyl)-1,4-dihydro-4-methyl-5H-tetrazol-5-one (Pyrazole), (D001) Carbendazim, (D007) Thiophanate methyl, (E004) Chlorothalonil, (E010) Dithianon, (E013) Mancozeb, (E020) Thiram , (L003) metalaxyl, (M001) fludioxonil, (N001) fluazinam, (O022) fluthiazole pyretinone, (O043) 2-{3-[2-(1-{[3,5 -Bis(difluoromethyl)-1H-pyrazol-1-yl)acetyl)pyridin-4-yl)-1,3-thiazol-4-yl)-4,5-dihydro-1, 2-oxazol-5-yl}-3-fluorophenyl methanesulfonate (Bayer "wonderful" fungicide), (O046) 3-(4,4,5-trifluoro-3,3-dimethyl -3,4-Dihydroisoquinolin-1-yl)quinoline, (O047) 3-(4,4-difluoro-3,3-dimethyl-3,4-dihydroisoquinolin-1 -Base) quinoline (quinoline fungicide), (O065) isoflurane, (P006) N-(2,4-difluorophenyl)-4-[5-(trifluoromethyl)- 1,2,4-oxadiazol-3-yl]benzamide and (P103) 5-methyl-1-[[4-[5-(trifluoromethyl)-1,2,4-oxa Diazol-3-yl]phenyl]methyl]pyrrolidin-2-one.
下列組合例是本發明的農用化學組合物的具體實施例。The following combination examples are specific examples of the agrochemical composition of the present invention.
下表-1所列的組合物（其中成分（1）——式(I)化合物，由運算式“(I)”表示，包括化合物I-1、I-2、I-3、1-4、I-5、I-6、I-7、I-8、I-9、I-10、I-11、I-12、I-13、I-14和I-15)，和從A)到P)組中選擇的另一個成分（2）的定義的例子為(例如成分2在(I)+(A001]中為(A001或環丙唑醇)）。The composition listed in the following table-1 (in which component (1)——the compound of formula (I), represented by the calculation formula "(I)", including compounds I-1, I-2, I-3, 1-4 , I-5, I-6, I-7, I-8, I-9, I-10, I-11, I-12, I-13, I-14 and I-15), and from A) An example of the definition of another component (2) selected in the P) group is (for example, component 2 is (A001 or cyproconazole) in (I)+(A001)).
表 -1 ： (I)+(A001), (I)+(A002), (I)+(A003), (I)+(A004), (I)+(A005), (I)+(A006), (I)+(A007), (I)+(A008), (I)+(A009), (I)+(A010), (I)+(A011), (I)+(A012), (I)+(A013), (I)+(A014), (I)+(A015), (I)+(A016), (I)+(A017), (I)+(A018), (I)+(A019), (I)+(A020), (I)+(A021), (I)+(A022), (I)+(A023), (I)+(A024), (I)+(A025), (I)+(A026), (I)+(A027), (I)+(A028), (I)+(A029), (I)+(A030), (I)+(A031), (I)+(A032), (I)+(A033), (I)+(A034), (I)+(A035), (I)+(A036), (I)+(A037), (I)+(A038), (I)+(A039), (I)+(A040), (I)+(A041), (I)+(A042), (I)+(A043), (I)+(A044), (I)+(A045), (I)+(A046), (I)+(A047), (I)+(A048), (I)+(A049), (I)+(A050), (I)+(A051), (I)+(A052), (I)+(A053), (I)+(A054), (I)+(A055), (I)+(A056), (I)+(A057), (I)+(A058), (I)+(A059), (I)+(A060), (I)+(A061), (I)+(A062), (I)+(A063), (I)+(A064), (I)+(A065), (I)+(A066), (I)+(A067), (I)+(A068), (I)+(A069), (I)+(A070), (I)+(A071), (I)+(A072), (I)+(A073), (I)+(A074), (I)+(A075), (I)+(A076), (I)+(A077), (I)+(A078), (I)+(A079), (I)+(A080), (I)+(A081), (I)+(A082), (I)+(A083), (I)+(A084), (I)+(B001), (I)+(B002), (I)+(B003), (I)+(B004), (I)+(B005), (I)+(B006), (I)+(B007), (I)+(B008), (I)+(B009), (I)+(B010), (I)+(B011), (I)+(B012), (I)+(B013), (I)+(B014), (I)+(B015), (I)+(B016), (I)+(B017), (I)+(B018), (I)+(B019), (I)+(B020), (I)+(B021), (I)+(B022), (I)+(B023), (I)+(B024), (I)+(B025), (I)+(B026), (I)+(B027), (I)+(B028), (I)+(B029), (I)+(B030), (I)+(B031), (I)+(B032), (I)+(B033), (I)+(B034), (I)+(B035), (I)+(B036), (I)+(B037), (I)+(B038), (I)+(B039), (I)+(B040), (I)+(B041), (I)+(B042), (I)+(B043), (I)+(B044), (I)+(B045), (I)+(B046), (I)+(B047), (I)+(B048), (I)+(B049), (I)+(B050), (I)+(B051), (I)+(B052), (I)+(B053), (I)+(B054), (I)+(B055), (I)+(B056), (I)+(B057), (I)+(B058), (I)+(B059), (I)+(B060), (I)+(C001), (I)+(C002), (I)+(C003), (I)+(C004), (I)+(C005), (I)+(C006), (I)+(C007), (I)+(C008), (I)+(C009), (I)+(C010), (I)+(C011), (I)+(C012), (I)+(C013), (I)+(C014), (I)+(C015), (I)+(C016), (I)+(C017), (I)+(C018), (I)+(C019), (I)+(C020), (I)+(C021), (I)+(C022), (I)+(C023), (I)+(C024), (I)+(C025), (I)+(C026), (I)+(C027), (I)+(C028), (I)+(C029), (I)+(C030), (I)+(D001), (I)+(D002), (I)+(D003), (I)+(D004), (I)+(D005), (I)+(D006), (I)+(D007), (I)+(D008), (I)+(D009), (I)+(D010), (I)+(D011), (I)+(D012), (I)+(D013), (I)+(D014), (I)+(D015), (I)+(D016), (I)+(D017), (I)+(D018), (I)+(D019), (I)+(D020), (I)+(D021), (I)+(D022), (I)+(D023), (I)+(D024), (I)+(D025), (I)+(E001), (I)+(E002), (I)+(E003), (I)+(E004), (I)+(E005), (I)+(E006), (I)+(E007), (I)+(E008), (I)+(E009), (I)+(E010), (I)+(E011), (I)+(E012), (I)+(E013), (I)+(E014), (I)+(E015), (I)+(E016), (I)+(E017), (I)+(E018), (I)+(E019), (I)+(E020), (I)+(E021), (I)+(E022), (I)+(E023), (I)+(F001), (I)+(F002), (I)+(F003), (I)+(F004), (I)+(G001), (I)+(G002), (I)+(G003), (I)+(G004), (I)+(G005), (I)+(G006), (I)+(H001), (I)+(I001), (I)+(I002), (I)+(I003), (I)+(I004), (I)+(I005), (I)+(I006), (I)+(I007), (I)+(I008), (I)+(I009), (I)+(J001), (I)+(J002), (I)+(J003), (I)+(K001), (I)+(K002), (I)+(L001), (I)+(L002), (I)+(L003), (I)+(L004), (I)+(M001), (I)+(M002), (I)+(M003), (I)+(M004), (I)+(M005), (I)+(M006), (I)+(N001), (I)+(N002), (I)+(O001), (I)+(O002), (I)+(O003), (I)+(O004), (I)+(O005), (I)+(O006), (I)+(O007), (I)+(O008), (I)+(O009), (I)+(O010), (I)+(O011), (I)+(O012), (I)+(O013), (I)+(O014), (I)+(O015), (I)+(O016), (I)+(O017), (I)+(O018), (I)+(O019), (I)+(O020), (I)+(O021), (I)+(O022), (I)+(O023), (I)+(O024), (I)+(O025), (I)+(O026), (I)+(O027), (I)+(O028), (I)+(O029), (I)+(O030), (I)+(O031), (I)+(O032), (I)+(O033), (I)+(O034), (I)+(O035), (I)+(O036), (I)+(O037), (I)+(O038), (I)+(O039), (I)+(O040), (I)+(O041), (I)+(O042), (I)+(O043), (I)+(O044), (I)+(O045), (I)+(O046), (I)+(O047), (I)+(O048), (I)+(O049), (I)+(O050), (I)+(O051), (I)+(O052), (I)+(O053), (I)+(O054), (I)+(O055), (I)+(O056), (I)+(O057), (I)+(O058), (I)+(O059), (I)+(O060), (I)+(O061), (I)+(O062), (I)+(O063), (I)+(O064), (I)+(O065), (I)+(P001), (I)+(P002), (I)+(P003), (I)+(P004), (I)+(P005), (I)+(P006), (I)+(P007), (I)+(P008), (I)+(P009), (I)+(P010), (I)+(P011), (I)+(P012), (I)+(P013), (I)+(P014), (I)+(P015), (I)+(P016), (I)+(P017), (I)+(P018), (I)+(P019), (I)+(P020), (I)+(P021), (I)+(P022), (I)+(P023), (I)+(P024), (I)+(P025), (I)+(P026), (I)+(P027), (I)+(P028), (I)+(P029), (I)+(P030), (I)+(P031), (I)+(P032), (I)+(P033), (I)+(P034), (I)+(P035), (I)+(P036), (I)+(P037), (I)+(P038), (I)+(P039), (I)+(P040), (I)+(P041), (I)+(P042), (I)+(P043), (I)+(P044), (I)+(P045), (I)+(P046), (I)+(P047), (I)+(P048), (I)+(P049), (I)+(P050), (I)+(P051), (I)+(P052), (I)+(P053), (I)+(P054), (I)+(P055), (I)+(P056), (I)+(P057), (I)+(P058), (I)+(P059), (I)+(P060), (I)+(P061), (I)+(P062), (I)+(P063), (I)+(P064), (I)+(P065), (I)+(P066), (I)+(P067), (I)+(P068), (I)+(P069), (I)+(P070), (I)+(P071), (I)+(P072), (I)+(P073), (I)+(P074), (I)+(P075), (I)+(P076), (I)+(P077), (I)+(P078), (I)+(P079), (I)+(P080), (I)+(P081), (I)+(P082), (I)+(P083), (I)+(P084), (I)+(P085), (I)+(P086), (I)+(P087), (I)+(P088), (I)+(P089), (I)+(P090), (I)+(P091), (I)+(P092), (I)+(P093), (I)+(P094), (I)+(P095), (I)+(P096), (I)+(P097), (I)+(P098), (I)+(P099), (I)+(P100), (I)+(P101), (I)+(P102), (I)+(P103), (I)+(P104), (I)+(Q001), (I)+(Q002)。 Table -1 : (I)+(A001), (I)+(A002), (I)+(A003), (I)+(A004), (I)+(A005), (I)+(A006 ), (I)+(A007), (I)+(A008), (I)+(A009), (I)+(A010), (I)+(A011), (I)+(A012), (I)+(A013), (I)+(A014), (I)+(A015), (I)+(A016), (I)+(A017), (I)+(A018), (I )+(A019), (I)+(A020), (I)+(A021), (I)+(A022), (I)+(A023), (I)+(A024), (I)+ (A025), (I)+(A026), (I)+(A027), (I)+(A028), (I)+(A029), (I)+(A030), (I)+(A031 ), (I)+(A032), (I)+(A033), (I)+(A034), (I)+(A035), (I)+(A036), (I)+(A037), (I)+(A038), (I)+(A039), (I)+(A040), (I)+(A041), (I)+(A042), (I)+(A043), (I )+(A044), (I)+(A045), (I)+(A046), (I)+(A047), (I)+(A048), (I)+(A049), (I)+ (A050), (I)+(A051), (I)+(A052), (I)+(A053), (I)+(A054), (I)+(A055), (I)+(A056 ), (I)+(A057), (I)+(A058), (I)+(A059), (I)+(A060), (I)+(A061), (I)+(A062), (I)+(A063), (I)+(A064), (I)+(A065), (I)+(A066), (I)+(A067), (I)+(A068), (I )+(A069), (I)+(A070), (I)+(A071), (I)+(A072), (I)+(A073), (I)+(A074), (I)+ (A075), (I)+(A076), (I)+(A077), (I)+(A078), (I)+(A079), (I)+(A080), (I)+(A081 ), (I)+(A082), (I)+(A083) , (I)+(A084), (I)+(B001), (I)+(B002), (I)+(B003), (I)+(B004), (I)+(B005), ( I)+(B006), (I)+(B007), (I)+(B008), (I)+(B009), (I)+(B010), (I)+(B011), (I) +(B012), (I)+(B013), (I)+(B014), (I)+(B015), (I)+(B016), (I)+(B017), (I)+( B018), (I)+(B019), (I)+(B020), (I)+(B021), (I)+(B022), (I)+(B023), (I)+(B024) , (I)+(B025), (I)+(B026), (I)+(B027), (I)+(B028), (I)+(B029), (I)+(B030), ( I)+(B031), (I)+(B032), (I)+(B033), (I)+(B034), (I)+(B035), (I)+(B036), (I) +(B037), (I)+(B038), (I)+(B039), (I)+(B040), (I)+(B041), (I)+(B042), (I)+( B043), (I)+(B044), (I)+(B045), (I)+(B046), (I)+(B047), (I)+(B048), (I)+(B049) , (I)+(B050), (I)+(B051), (I)+(B052), (I)+(B053), (I)+(B054), (I)+(B055), ( I)+(B056), (I)+(B057), (I)+(B058), (I)+(B059), (I)+(B060), (I)+(C001), (I) +(C002), (I)+(C003), (I)+(C004), (I)+(C005), (I)+(C006), (I)+(C007), (I)+( C008), (I)+(C009), (I)+(C010), (I)+(C011), (I)+(C012), (I)+(C013), (I)+(C014) , (I)+(C015), (I)+(C016), (I)+(C017), (I)+(C018), (I)+(C019), (I)+(C020), ( I)+(C021), (I)+(C022), (I )+(C023), (I)+(C024), (I)+(C025), (I)+(C026), (I)+(C027), (I)+(C028), (I)+ (C029), (I)+(C030), (I)+(D001), (I)+(D002), (I)+(D003), (I)+(D004), (I)+(D005 ), (I)+(D006), (I)+(D007), (I)+(D008), (I)+(D009), (I)+(D010), (I)+(D011), (I)+(D012), (I)+(D013), (I)+(D014), (I)+(D015), (I)+(D016), (I)+(D017), (I )+(D018), (I)+(D019), (I)+(D020), (I)+(D021), (I)+(D022), (I)+(D023), (I)+ (D024), (I)+(D025), (I)+(E001), (I)+(E002), (I)+(E003), (I)+(E004), (I)+(E005 ), (I)+(E006), (I)+(E007), (I)+(E008), (I)+(E009), (I)+(E010), (I)+(E011), (I)+(E012), (I)+(E013), (I)+(E014), (I)+(E015), (I)+(E016), (I)+(E017), (I )+(E018), (I)+(E019), (I)+(E020), (I)+(E021), (I)+(E022), (I)+(E023), (I)+ (F001), (I)+(F002), (I)+(F003), (I)+(F004), (I)+(G001), (I)+(G002), (I)+(G003 ), (I)+(G004), (I)+(G005), (I)+(G006), (I)+(H001), (I)+(I001), (I)+(I002), (I)+(I003), (I)+(I004), (I)+(I005), (I)+(I006), (I)+(I007), (I)+(I008), (I )+(I009), (I)+(J001), (I)+(J002), (I)+(J003), (I)+(K001), (I)+(K002), (I)+ (L001), (I)+(L002), (I)+(L 003), (I)+(L004), (I)+(M001), (I)+(M002), (I)+(M003), (I)+(M004), (I)+(M005) , (I)+(M006), (I)+(N001), (I)+(N002), (I)+(O001), (I)+(O002), (I)+(O003), ( I)+(O004), (I)+(O005), (I)+(O006), (I)+(O007), (I)+(O008), (I)+(O009), (I) +(O010), (I)+(O011), (I)+(O012), (I)+(O013), (I)+(O014), (I)+(O015), (I)+( O016), (I)+(O017), (I)+(O018), (I)+(O019), (I)+(O020), (I)+(O021), (I)+(O022) , (I)+(O023), (I)+(O024), (I)+(O025), (I)+(O026), (I)+(O027), (I)+(O028), ( I)+(O029), (I)+(O030), (I)+(O031), (I)+(O032), (I)+(O033), (I)+(O034), (I) +(O035), (I)+(O036), (I)+(O037), (I)+(O038), (I)+(O039), (I)+(O040), (I)+( O041), (I)+(O042), (I)+(O043), (I)+(O044), (I)+(O045), (I)+(O046), (I)+(O047) , (I)+(O048), (I)+(O049), (I)+(O050), (I)+(O051), (I)+(O052), (I)+(O053), ( I)+(O054), (I)+(O055), (I)+(O056), (I)+(O057), (I)+(O058), (I)+(O059), (I) +(O060), (I)+(O061), (I)+(O062), (I)+(O063), (I)+(O064), (I)+(O065), (I)+( P001), (I)+(P002), (I)+(P003), (I)+(P004), (I)+(P005), (I)+(P006), (I)+(P007) , (I)+(P008), (I)+(P009) , (I)+(P010), (I)+(P011), (I)+(P012), (I)+(P013), (I)+(P014), (I)+(P015), ( I)+(P016), (I)+(P017), (I)+(P018), (I)+(P019), (I)+(P020), (I)+(P021), (I) +(P022), (I)+(P023), (I)+(P024), (I)+(P025), (I)+(P026), (I)+(P027), (I)+( P028), (I)+(P029), (I)+(P030), (I)+(P031), (I)+(P032), (I)+(P033), (I)+(P034) , (I)+(P035), (I)+(P036), (I)+(P037), (I)+(P038), (I)+(P039), (I)+(P040), ( I)+(P041), (I)+(P042), (I)+(P043), (I)+(P044), (I)+(P045), (I)+(P046), (I) +(P047), (I)+(P048), (I)+(P049), (I)+(P050), (I)+(P051), (I)+(P052), (I)+( P053), (I)+(P054), (I)+(P055), (I)+(P056), (I)+(P057), (I)+(P058), (I)+(P059) , (I)+(P060), (I)+(P061), (I)+(P062), (I)+(P063), (I)+(P064), (I)+(P065), ( I)+(P066), (I)+(P067), (I)+(P068), (I)+(P069), (I)+(P070), (I)+(P071), (I) +(P072), (I)+(P073), (I)+(P074), (I)+(P075), (I)+(P076), (I)+(P077), (I)+( P078), (I)+(P079), (I)+(P080), (I)+(P081), (I)+(P082), (I)+(P083), (I)+(P084) , (I)+(P085), (I)+(P086), (I)+(P087), (I)+(P088), (I)+(P089), (I)+(P090), ( I)+(P091), (I)+(P092), (I )+(P093), (I)+(P094), (I)+(P095), (I)+(P096), (I)+(P097), (I)+(P098), (I)+ (P099), (I)+(P100), (I)+(P101), (I)+(P102), (I)+(P103), (I)+(P104), (I)+(Q001 ), (I)+(Q002).
在一個實施方案中，在表1的組合物[（I）+（A001）至[（I）+（Q002）]中，成分（1）與成分（2）的重量比在100：1至1：100之間。In one embodiment, in the compositions [(I)+(A001) to [(I)+(Q002)] in Table 1, the weight ratio of ingredient (1) to ingredient (2) is 100:1 to 1. : Between 100.
在一個實施方案中，在表1的組合物[（I）+（A001）至[（I）+（Q002）]中，成分（1）與成分（2）的重量比在50：1至1：50之間。In one embodiment, in the compositions [(I)+(A001) to [(I)+(Q002)] in Table 1, the weight ratio of ingredient (1) to ingredient (2) is 50:1 to 1. : Between 50.
在一個實施方案中，在表1的組合物[（I）+（A001）至[（I）+（Q002）]中，成分（1）與成分（2）的重量比在20：1至1：20之間。In one embodiment, in the compositions [(I)+(A001) to [(I)+(Q002)] in Table 1, the weight ratio of ingredient (1) to ingredient (2) is 20:1 to 1. : Between 20.
在一個實施方案中，在表1的組合物[（I）+（A001）至[（I）+（Q002）]中，成分（1）與成分（2）的重量比在5：1至1：5之間。In one embodiment, in the compositions [(I)+(A001) to [(I)+(Q002)] in Table 1, the weight ratio of ingredient (1) to ingredient (2) is 5:1 to 1. : Between 5.
在一個實施方案中，在表1的組合物[（I）+（A001）至[（I）+（Q002）]中，成分（1）與成分（2）的重量比在3：1至1：3之間。In one embodiment, in the compositions [(I)+(A001) to [(I)+(Q002)] in Table 1, the weight ratio of ingredient (1) to ingredient (2) is 3:1 to 1. : Between 3.
在一個實施方案中，在表1的組合物[（I）+（A001）至[（I）+（Q002）]中，成分（1）與成分（2）的重量比為1:1。In one embodiment, in the compositions [(I)+(A001) to [(I)+(Q002)] in Table 1, the weight ratio of ingredient (1) to ingredient (2) is 1:1.
特別地，下表2中所定義的組合物，其中成分（1）為化合物（I-1），成分（2）選自A）至P）組。In particular, the composition defined in Table 2 below, wherein component (1) is compound (I-1), and component (2) is selected from groups A) to P).
表 -2 (I-1)+(A001), (I-1)+(A002), (I-1)+(A003), (I-1)+(A004), (I-1)+(A005), (I-1)+(A006), (I-1)+(A007), (I-1)+(A008), (I-1)+(A009), (I-1)+(A010), (I-1)+(A011), (I-1)+(A012), (I-1)+(A013), (I-1)+(A014), (I-1)+(A015), (I-1)+(A016), (I-1)+(A017), (I-1)+(A018), (I-1)+(A019), (I-1)+(A020), (I-1)+(A021), (I-1)+(A022), (I-1)+(A023), (I-1)+(A024), (I-1)+(A025), (I-1)+(A026), (I-1)+(A027), (I-1)+(A028), (I-1)+(A029), (I-1)+(A030), (I-1)+(A031), (I-1)+(A032), (I-1)+(A033), (I-1)+(A034), (I-1)+(A035), (I-1)+(A036), (I-1)+(A037), (I-1)+(A038), (I-1)+(A039), (I-1)+(A040), (I-1)+(A041), (I-1)+(A042), (I-1)+(A043), (I-1)+(A044), (I-1)+(A045), (I-1)+(A046), (I-1)+(A047), (I-1)+(A048), (I-1)+(A049), (I-1)+(A050), (I-1)+(A051), (I-1)+(A052), (I-1)+(A053), (I-1)+(A054), (I-1)+(A055), (I-1)+(A056), (I-1)+(A057), (I-1)+(A058), (I-1)+(A059), (I-1)+(A060), (I-1)+(A061), (I-1)+(A062), (I-1)+(A063), (I-1)+(A064), (I-1)+(A065), (I-1)+(A066), (I-1)+(A067), (I-1)+(A068), (I-1)+(A069), (I-1)+(A070), (I-1)+(A071), (I-1)+(A072), (I-1)+(A073), (I-1)+(A074), (I-1)+(A075), (I-1)+(A076), (I-1)+(A077), (I-1)+(A078), (I-1)+(A079), (I-1)+(A080), (I-1)+(A081), (I-1)+(A082), (I-1)+(A083), (I-1)+(A084), (I-1)+(B001), (I-1)+(B002), (I-1)+(B003), (I-1)+(B004), (I-1)+(B005), (I-1)+(B006), (I-1)+(B007), (I-1)+(B008), (I-1)+(B009), (I-1)+(B010), (I-1)+(B011), (I-1)+(B012), (I-1)+(B013), (I-1)+(B014), (I-1)+(B015), (I-1)+(B016), (I-1)+(B017), (I-1)+(B018), (I-1)+(B019), (I-1)+(B020), (I-1)+(B021), (I-1)+(B022), (I-1)+(B023), (I-1)+(B024), (I-1)+(B025), (I-1)+(B026), (I-1)+(B027), (I-1)+(B028), (I-1)+(B029), (I-1)+(B030), (I-1)+(B031), (I-1)+(B032), (I-1)+(B033), (I-1)+(B034), (I-1)+(B035), (I-1)+(B036), (I-1)+(B037), (I-1)+(B038), (I-1)+(B039), (I-1)+(B040), (I-1)+(B041), (I-1)+(B042), (I-1)+(B043), (I-1)+(B044), (I-1)+(B045), (I-1)+(B046), (I-1)+(B047), (I-1)+(B048), (I-1)+(B049), (I-1)+(B050), (I-1)+(B051), (I-1)+(B052), (I-1)+(B053), (I-1)+(B054), (I-1)+(B055), (I-1)+(B056), (I-1)+(B057), (I-1)+(C001), (I-1)+(C002), (I-1)+(C003), (I-1)+(C004), (I-1)+(C005), (I-1)+(C006), (I-1)+(C007), (I-1)+(C008), (I-1)+(C009), (I-1)+(C010), (I-1)+(C011), (I-1)+(C012), (I-1)+(C013), (I-1)+(C014), (I-1)+(C015), (I-1)+(C016), (I-1)+(C017), (I-1)+(C018), (I-1)+(C019), (I-1)+(C020), (I-1)+(C021), (I-1)+(C022), (I-1)+(C023), (I-1)+(C024), (I-1)+(C025), (I-1)+(C026), (I-1)+(C027), (I-1)+(C028), (I-1)+(C029), (I-1)+(C030), (I-1)+(D001), (I-1)+(D002), (I-1)+(D003), (I-1)+(D004), (I-1)+(D005), (I-1)+(D006), (I-1)+(D007), (I-1)+(D008), (I-1)+(D009), (I-1)+(D010), (I-1)+(D011), (I-1)+(D012), (I-1)+(D013), (I-1)+(D014), (I-1)+(D015), (I-1)+(D016), (I-1)+(D017), (I-1)+(D018), (I-1)+(D019), (I-1)+(D020), (I-1)+(D021), (I-1)+(D022), (I-1)+(D023), (I-1)+(D024), (I-1)+(D025), (I-1)+(E001), (I-1)+(E002), (I-1)+(E003), (I-1)+(E004), (I-1)+(E005), (I-1)+(E006), (I-1)+(E007), (I-1)+(E008), (I-1)+(E009), (I-1)+(E010), (I-1)+(E011), (I-1)+(E012), (I-1)+(E013), (I-1)+(E014), (I-1)+(E015), (I-1)+(E016), (I-1)+(E017), (I-1)+(E018), (I-1)+(E019), (I-1)+(E020), (I-1)+(E021), (I-1)+(E022), (I-1)+(E023), (I-1)+(F001), (I-1)+(F002), (I-1)+(F003), (I-1)+(F004), (I-1)+(G001), (I-1)+(G002), (I-1)+(G003), (I-1)+(G004), (I-1)+(G005), (I-1)+(G006), (I-1)+(H001), (I-1)+(I001), (I-1)+(I002), (I-1)+(I003), (I-1)+(I004), (I-1)+(I005), (I-1)+(I006), (I-1)+(I007), (I-1)+(I008), (I-1)+(I009), (I-1)+(J001), (I-1)+(J002), (I-1)+(J003), (I-1)+(K001), (I-1)+(K002), (I-1)+(L001), (I-1)+(L002), (I-1)+(L003), (I-1)+(L004), (I-1)+(M001), (I-1)+(M002), (I-1)+(M003), (I-1)+(M004), (I-1)+(M005), (I-1)+(M006), (I-1)+(N001), (I-1)+(N002), (I-1)+(O001), (I-1)+(O002), (I-1)+(O003), (I-1)+(O004), (I-1)+(O005), (I-1)+(O006), (I-1)+(O007), (I-1)+(O008), (I-1)+(O009), (I-1)+(O010), (I-1)+(O011), (I-1)+(O012), (I-1)+(O013), (I-1)+(O014), (I-1)+(O015), (I-1)+(O016), (I-1)+(O017), (I-1)+(O018), (I-1)+(O019), (I-1)+(O020), (I-1)+(O021), (I-1)+(O022), (I-1)+(O023), (I-1)+(O024), (I-1)+(O025), (I-1)+(O026), (I-1)+(O027), (I-1)+(O028), (I-1)+(O029), (I-1)+(O030), (I-1)+(O031), (I-1)+(O032), (I-1)+(O033), (I-1)+(O034), (I-1)+(O035), (I-1)+(O036), (I-1)+(O037), (I-1)+(O038), (I-1)+(O039), (I-1)+(O040), (I-1)+(O041), (I-1)+(O042), (I-1)+(O043), (I-1)+(O044), (I-1)+(O045), (I-1)+(O046), (I-1)+(O047), (I-1)+(O048), (I-1)+(O049), (I-1)+(O050), (I-1)+(O051), (I-1)+(O052), (I-1)+(O053), (I-1)+(O054), (I-1)+(O055), (I-1)+(O056), (I-1)+(O057), (I-1)+(O058), (I-1)+(O059), (I-1)+(O060), (I-1)+(O061), (I-1)+(O062), (I-1)+(O063), (I-1)+(O064), (I-1)+(O065), (I-1)+(P001), (I-1)+(P002), (I-1)+(P003), (I-1)+(P004), (I-1)+(P005), (I-1)+(P006), (I-1)+(P007), (I-1)+(P008), (I-1)+(P009), (I-1)+(P010), (I-1)+(P011), (I-1)+(P012), (I-1)+(P013), (I-1)+(P014), (I-1)+(P015), (I-1)+(P016), (I-1)+(P017), (I-1)+(P018), (I-1)+(P019), (I-1)+(P020), (I-1)+(P021), (I-1)+(P022), (I-1)+(P023), (I-1)+(P024), (I-1)+(P025), (I-1)+(P026), (I-1)+(P027), (I-1)+(P028), (I-1)+(P029), (I-1)+(P030), (I-1)+(P031), (I-1)+(P032), (I-1)+(P033), (I-1)+(P034), (I-1)+(P035), (I-1)+(P036), (I-1)+(P037), (I-1)+(P038), (I-1)+(P039), (I-1)+(P040), (I-1)+(P041), (I-1)+(P042), (I-1)+(P043), (I-1)+(P044), (I-1)+(P045), (I-1)+(P046), (I-1)+(P047), (I-1)+(P048), (I-1)+(P049), (I-1)+(P050), (I-1)+(P051), (I-1)+(P052), (I-1)+(P053), (I-1)+(P054), (I-1)+(P055), (I-1)+(P056), (I-1)+(P057), (I-1)+(P058), (I-1)+(P059), (I-1)+(P060), (I-1)+(P061), (I-1)+(P062), (I-1)+(P063), (I-1)+(P064), (I-1)+(P065), (I-1)+(P066), (I-1)+(P067), (I-1)+(P068), (I-1)+(P069), (I-1)+(P070), (I-1)+(P071), (I-1)+(P072), (I-1)+(P073), (I-1)+(P074), (I-1)+(P075), (I-1)+(P076), (I-1)+(P077), (I-1)+(P078), (I-1)+(P079), (I-1)+(P080), (I-1)+(P081), (I-1)+(P082), (I-1)+(P083), (I-1)+(P084), (I-1)+(P085), (I-1)+(P086), (I-1)+(P087), (I-1)+(P088), (I-1)+(P089), (I-1)+(P090), (I-1)+(P091), (I-1)+(P092), (I-1)+(P093), (I-1)+(P094), (I-1)+(P095), (I-1)+(P096), (I-1)+(P097), (I-1)+(P098), (I-1)+(P099), (I-1)+(P100), (I-1)+(P101), (I-1)+(P102), (I-1)+(P103), (I-1)+(P104), (I-1)+(Q001), (I-1)+(Q002)。 Table -2 (I-1)+(A001), (I-1)+(A002), (I-1)+(A003), (I-1)+(A004), (I-1)+( A005), (I-1)+(A006), (I-1)+(A007), (I-1)+(A008), (I-1)+(A009), (I-1)+( A010), (I-1)+(A011), (I-1)+(A012), (I-1)+(A013), (I-1)+(A014), (I-1)+( A015), (I-1)+(A016), (I-1)+(A017), (I-1)+(A018), (I-1)+(A019), (I-1)+( A020), (I-1)+(A021), (I-1)+(A022), (I-1)+(A023), (I-1)+(A024), (I-1)+( A025), (I-1)+(A026), (I-1)+(A027), (I-1)+(A028), (I-1)+(A029), (I-1)+( A030), (I-1)+(A031), (I-1)+(A032), (I-1)+(A033), (I-1)+(A034), (I-1)+( A035), (I-1)+(A036), (I-1)+(A037), (I-1)+(A038), (I-1)+(A039), (I-1)+( A040), (I-1)+(A041), (I-1)+(A042), (I-1)+(A043), (I-1)+(A044), (I-1)+( A045), (I-1)+(A046), (I-1)+(A047), (I-1)+(A048), (I-1)+(A049), (I-1)+( A050), (I-1)+(A051), (I-1)+(A052), (I-1)+(A053), (I-1)+(A054), (I-1)+( A055), (I-1)+(A056), (I-1)+(A057), (I-1)+(A058), (I-1)+(A059), (I-1)+( A060), (I-1)+(A061), (I-1)+(A062), (I-1)+(A063), (I-1)+(A064), (I-1)+( A065), (I-1)+(A066), (I-1)+(A067), (I-1)+(A068), (I-1)+(A069), (I-1)+( A070), (I-1)+(A071), (I -1)+(A072), (I-1)+(A073), (I-1)+(A074), (I-1)+(A075), (I-1)+(A076), (I -1)+(A077), (I-1)+(A078), (I-1)+(A079), (I-1)+(A080), (I-1)+(A081), (I -1)+(A082), (I-1)+(A083), (I-1)+(A084), (I-1)+(B001), (I-1)+(B002), (I -1)+(B003), (I-1)+(B004), (I-1)+(B005), (I-1)+(B006), (I-1)+(B007), (I -1)+(B008), (I-1)+(B009), (I-1)+(B010), (I-1)+(B011), (I-1)+(B012), (I -1)+(B013), (I-1)+(B014), (I-1)+(B015), (I-1)+(B016), (I-1)+(B017), (I -1)+(B018), (I-1)+(B019), (I-1)+(B020), (I-1)+(B021), (I-1)+(B022), (I -1)+(B023), (I-1)+(B024), (I-1)+(B025), (I-1)+(B026), (I-1)+(B027), (I -1)+(B028), (I-1)+(B029), (I-1)+(B030), (I-1)+(B031), (I-1)+(B032), (I -1)+(B033), (I-1)+(B034), (I-1)+(B035), (I-1)+(B036), (I-1)+(B037), (I -1)+(B038), (I-1)+(B039), (I-1)+(B040), (I-1)+(B041), (I-1)+(B042), (I -1)+(B043), (I-1)+(B044), (I-1)+(B045), (I-1)+(B046), (I-1)+(B047), (I -1)+(B048), (I-1)+(B049), (I-1)+(B050), (I-1)+(B051), (I-1)+(B052), (I -1)+(B053), (I-1)+(B054), (I-1)+(B055), (I-1)+(B056), (I-1)+(B057), (I -1)+(C001), (I-1)+(C 002), (I-1)+(C003), (I-1)+(C004), (I-1)+(C005), (I-1)+(C006), (I-1)+( C007), (I-1)+(C008), (I-1)+(C009), (I-1)+(C010), (I-1)+(C011), (I-1)+( C012), (I-1)+(C013), (I-1)+(C014), (I-1)+(C015), (I-1)+(C016), (I-1)+( C017), (I-1)+(C018), (I-1)+(C019), (I-1)+(C020), (I-1)+(C021), (I-1)+( C022), (I-1)+(C023), (I-1)+(C024), (I-1)+(C025), (I-1)+(C026), (I-1)+( C027), (I-1)+(C028), (I-1)+(C029), (I-1)+(C030), (I-1)+(D001), (I-1)+( D002), (I-1)+(D003), (I-1)+(D004), (I-1)+(D005), (I-1)+(D006), (I-1)+( D007), (I-1)+(D008), (I-1)+(D009), (I-1)+(D010), (I-1)+(D011), (I-1)+( D012), (I-1)+(D013), (I-1)+(D014), (I-1)+(D015), (I-1)+(D016), (I-1)+( D017), (I-1)+(D018), (I-1)+(D019), (I-1)+(D020), (I-1)+(D021), (I-1)+( D022), (I-1)+(D023), (I-1)+(D024), (I-1)+(D025), (I-1)+(E001), (I-1)+( E002), (I-1)+(E003), (I-1)+(E004), (I-1)+(E005), (I-1)+(E006), (I-1)+( E007), (I-1)+(E008), (I-1)+(E009), (I-1)+(E010), (I-1)+(E011), (I-1)+( E012), (I-1)+(E013), (I-1)+(E014), (I-1)+(E015), (I-1)+(E016), (I-1)+( E017), (I-1)+(E018), (I-1)+(E019), (I-1)+(E020), (I-1)+(E021), (I-1)+(E022), (I-1)+(E023), (I-1)+(F001), (I-1)+(F002), (I-1)+(F003), (I-1)+(F004), (I-1)+(G001), (I-1)+(G002), (I-1)+(G003), (I-1)+(G004), (I-1)+(G005), (I-1)+(G006), (I-1)+(H001), (I-1)+(I001), (I-1)+(I002), (I-1)+(I003), (I-1)+(I004), (I-1)+(I005), (I-1)+(I006), (I-1)+(I007), (I-1)+(I008), (I-1)+(I009), (I-1)+(J001), (I-1)+(J002), (I-1)+(J003), (I-1)+(K001), (I-1)+(K002), (I-1)+(L001), (I-1)+(L002), (I-1)+(L003), (I-1)+(L004), (I-1)+(M001), (I-1)+(M002), (I-1)+(M003), (I-1)+(M004), (I-1)+(M005), (I-1)+(M006), (I-1)+(N001), (I-1)+(N002), (I-1)+(O001), (I-1)+(O002), (I-1)+(O003), (I-1)+(O004), (I-1)+(O005), (I-1)+(O006), (I-1)+(O007), (I-1)+(O008), (I-1)+(O009), (I-1)+(O010), (I-1)+(O011), (I-1)+(O012), (I-1)+(O013), (I-1)+(O014), (I-1)+(O015), (I-1)+(O016), (I-1)+(O017), (I-1)+(O018), (I-1)+(O019), (I-1)+(O020), (I-1)+(O021), (I-1)+(O022), (I-1)+(O023), (I-1)+(O024), (I-1)+(O025), (I-1)+(O026), (I-1)+(O027), (I-1)+(O028), (I-1)+(O029), (I-1)+ (O030), (I-1)+(O031), (I-1)+(O032), (I-1)+(O033), (I-1)+(O034), (I-1)+ (O035), (I-1)+(O036), (I-1)+(O037), (I-1)+(O038), (I-1)+(O039), (I-1)+ (O040), (I-1)+(O041), (I-1)+(O042), (I-1)+(O043), (I-1)+(O044), (I-1)+ (O045), (I-1)+(O046), (I-1)+(O047), (I-1)+(O048), (I-1)+(O049), (I-1)+ (O050), (I-1)+(O051), (I-1)+(O052), (I-1)+(O053), (I-1)+(O054), (I-1)+ (O055), (I-1)+(O056), (I-1)+(O057), (I-1)+(O058), (I-1)+(O059), (I-1)+ (O060), (I-1)+(O061), (I-1)+(O062), (I-1)+(O063), (I-1)+(O064), (I-1)+ (O065), (I-1)+(P001), (I-1)+(P002), (I-1)+(P003), (I-1)+(P004), (I-1)+ (P005), (I-1)+(P006), (I-1)+(P007), (I-1)+(P008), (I-1)+(P009), (I-1)+ (P010), (I-1)+(P011), (I-1)+(P012), (I-1)+(P013), (I-1)+(P014), (I-1)+ (P015), (I-1)+(P016), (I-1)+(P017), (I-1)+(P018), (I-1)+(P019), (I-1)+ (P020), (I-1)+(P021), (I-1)+(P022), (I-1)+(P023), (I-1)+(P024), (I-1)+ (P025), (I-1)+(P026), (I-1)+(P027), (I-1)+(P028), (I-1)+(P029), (I-1)+ (P030), (I-1)+(P031), (I-1)+(P032), (I-1)+(P033), (I-1)+(P034), (I-1)+ (P035), (I-1)+(P036) , (I-1)+(P037), (I-1)+(P038), (I-1)+(P039), (I-1)+(P040), (I-1)+(P041) , (I-1)+(P042), (I-1)+(P043), (I-1)+(P044), (I-1)+(P045), (I-1)+(P046) , (I-1)+(P047), (I-1)+(P048), (I-1)+(P049), (I-1)+(P050), (I-1)+(P051) , (I-1)+(P052), (I-1)+(P053), (I-1)+(P054), (I-1)+(P055), (I-1)+(P056) , (I-1)+(P057), (I-1)+(P058), (I-1)+(P059), (I-1)+(P060), (I-1)+(P061) , (I-1)+(P062), (I-1)+(P063), (I-1)+(P064), (I-1)+(P065), (I-1)+(P066) , (I-1)+(P067), (I-1)+(P068), (I-1)+(P069), (I-1)+(P070), (I-1)+(P071) , (I-1)+(P072), (I-1)+(P073), (I-1)+(P074), (I-1)+(P075), (I-1)+(P076) , (I-1)+(P077), (I-1)+(P078), (I-1)+(P079), (I-1)+(P080), (I-1)+(P081) , (I-1)+(P082), (I-1)+(P083), (I-1)+(P084), (I-1)+(P085), (I-1)+(P086) , (I-1)+(P087), (I-1)+(P088), (I-1)+(P089), (I-1)+(P090), (I-1)+(P091) , (I-1)+(P092), (I-1)+(P093), (I-1)+(P094), (I-1)+(P095), (I-1)+(P096) , (I-1)+(P097), (I-1)+(P098), (I-1)+(P099), (I-1)+(P100), (I-1)+(P101) , (I-1)+(P102), (I-1)+(P103), (I-1)+(P104), (I-1)+(Q001), (I-1)+(Q002) .
表 3 ： 組合物[（I-2）+（A001]至[（I-2）+（Q002）]與表2中的組合物[[I-1）+（A001]至[（I-1）+（Q002）]的定義類似，其中每種混合物中的化合物（I-2）用化合物（I-1）代替。 Table 3 : Composition [(I-2)+(A001] to [(I-2)+(Q002)] and the composition in Table 2 [[I-1)+(A001] to [(I-1 )+(Q002)] has a similar definition, where the compound (I-2) in each mixture is replaced by the compound (I-1).
表 4 ： 組合物[（I-3）+（A001]至[（I-3）+（Q002）]與表2中的組合物[[I-1）+（A001]至[（I-1）+（Q002）]的定義類似，其中每種混合物中的化合物（I-3）用化合物（I-1）代替。 Table 4 : Composition [(I-3)+(A001] to [(I-3)+(Q002)] and the composition in Table 2 [[I-1)+(A001] to [(I-1 )+(Q002)] has a similar definition, where the compound (I-3) in each mixture is replaced by the compound (I-1).
表 5 ： 組合物[（I-4）+（A001]至[（I-4）+（Q002）]與表2中的組合物[[I-1）+（A001]至[（I-1）+（Q002）]的定義類似，其中每種混合物中的化合物（I-1）用化合物（I-4）代替。 Table 5 : Composition [(I-4)+(A001] to [(I-4)+(Q002)] and the composition in Table 2 [[I-1)+(A001] to [(I-1 )+(Q002)] has a similar definition, wherein compound (I-1) in each mixture is replaced with compound (I-4).
表 6 ： 組合物[（I-5）+（A001]至[（I-5）+（Q002）]與表2中的組合物[[I-1）+（A001]至[（I-1）+（Q002）]的定義類似，其中每種混合物中的化合物（I-1）用化合物（I-5）代替。 Table 6 : Compositions [(I-5)+(A001] to [(I-5)+(Q002)] and the compositions in Table 2 [[I-1)+(A001] to [(I-1 )+(Q002)] has a similar definition, wherein compound (I-1) in each mixture is replaced with compound (I-5).
表 7 ： 組合物[（I-6）+（A001]至[（I-6）+（Q002）]與表2中的組合物[[I-1）+（A001]至[（I-1）+（Q002）]的定義類似，其中每種混合物中的化合物（I-1）用化合物（I-6）代替。 Table 7 : Composition [(I-6)+(A001] to [(I-6)+(Q002)] and the composition in Table 2 [[I-1)+(A001] to [(I-1 )+(Q002)] has a similar definition, wherein compound (I-1) in each mixture is replaced with compound (I-6).
表 8 ： 組合物[（I-7）+（A001]至[（I-7）+（Q002）]與表2中的組合物[[I-1）+（A001]至[（I-1）+（Q002）]的定義類似，其中每種混合物中的化合物（I-1）用化合物（I-7）代替。 Table 8 : Composition [(I-7)+(A001] to [(I-7)+(Q002)] and the composition in Table 2 [[I-1)+(A001] to [(I-1 )+(Q002)] has a similar definition, wherein compound (I-1) in each mixture is replaced with compound (I-7).
表 9 ： 組合物[（I-8）+（A001]至[（I-8）+（Q002）]與表2中的組合物[[I-1）+（A001]至[（I-1）+（Q002）]的定義類似，其中每種混合物中的化合物（I-1）用化合物（I-8）代替。 Table 9 : Composition [(I-8)+(A001] to [(I-8)+(Q002)] and the composition in Table 2 [[I-1)+(A001] to [(I-1 )+(Q002)] has a similar definition, wherein compound (I-1) in each mixture is replaced with compound (I-8).
表 10 ： 組合物[（I-9）+（A001]至[（I-9）+（Q002）]與表2中的組合物[[I-1）+（A001]至[（I-1）+（Q002）]的定義類似，其中每種混合物中的化合物（I-1）用化合物（I-9）代替。 Table 10 : Compositions [(I-9)+(A001] to [(I-9)+(Q002)] and the compositions in Table 2 [[I-1)+(A001] to [(I-1 )+(Q002)] has a similar definition, wherein compound (I-1) in each mixture is replaced with compound (I-9).
表 11 ： 組合物[（I-10）+（A001]至[（I-10）+（Q002）]與表2中的組合物[[I-1）+（A001]至[（I-1）+（Q002）]的定義類似，其中每種混合物中的化合物（I-1）用化合物（I-10）代替。 Table 11 : Composition [(I-10)+(A001] to [(I-10)+(Q002)] and the composition in Table 2 [[I-1)+(A001] to [(I-1 )+(Q002)] has a similar definition, wherein compound (I-1) in each mixture is replaced with compound (I-10).
表 12 ： 組合物[（I-11）+（A001]至[（I-11）+（Q002）]與表2中的組合物[[I-1）+（A001]至[（I-1）+（Q002）]的定義類似，其中每種混合物中的化合物（I-1）用化合物（I-11）代替。 Table 12 : Composition [(I-11)+(A001] to [(I-11)+(Q002)] and the composition in Table 2 [[I-1)+(A001] to [(I-1 )+(Q002)] has a similar definition, wherein compound (I-1) in each mixture is replaced with compound (I-11).
表 13 ： 組合物[（I-12）+（A001]至[（I-12）+（Q002）]與表2中的組合物[[I-1）+（A001]至[（I-1）+（Q002）]的定義類似，其中每種混合物中的化合物（I-1）用化合物（I-12）代替。 Table 13 : Composition [(I-12)+(A001] to [(I-12)+(Q002)] and the composition in Table 2 [[I-1)+(A001] to [(I-1 )+(Q002)] has a similar definition, wherein compound (I-1) in each mixture is replaced with compound (I-12).
表 14 ： 組合物[（I-13）+（A001]至[（I-13）+（Q002）]與表2中的組合物[[I-1）+（A001]至[（I-1）+（Q002）]的定義類似，其中每種混合物中的化合物（I-1）用化合物（I-13）代替。 Table 14 : Composition [(I-13)+(A001] to [(I-13)+(Q002)] and the composition in Table 2 [[I-1)+(A001] to [(I-1 )+(Q002)] has a similar definition, wherein compound (I-1) in each mixture is replaced with compound (I-13).
表 15 ： 組合物[（I-14）+（A001]至[（I-14）+（Q002）]與表2中的組合物[[I-1）+（A001]至[（I-1）+（Q002）]的定義類似，其中每種混合物中的化合物（I-1）用化合物（I-14）代替。 Table 15 : Composition [(I-14)+(A001] to [(I-14)+(Q002)] and the composition in Table 2 [[I-1)+(A001] to [(I-1 )+(Q002)] has a similar definition, wherein compound (I-1) in each mixture is replaced with compound (I-14).
表 16 ： 組合物[（I-15）+（A001]至[（I-15）+（Q002）]與表2中的組合物[[I-1）+（A001]至[（I-1）+（Q002）]的定義類似，其中每種混合物中的化合物（I-1）用化合物（I-15）代替。 Table 16 : Composition [(I-15)+(A001] to [(I-15)+(Q002)] and the composition in Table 2 [[I-1)+(A001] to [(I-1 )+(Q002)] has a similar definition, wherein compound (I-1) in each mixture is replaced with compound (I-15).
在一個實施方案中，本發明提供用於控制或預防農作物和/或園藝作物免受由植物病原真菌引起的疾病的殺菌組合物的用途。In one embodiment, the present invention provides the use of a bactericidal composition for controlling or preventing agricultural crops and/or horticultural crops from diseases caused by phytopathogenic fungi.
在優選實施方案中，表1至表16中公開的組合物（尤其是當這些混合物的成分（1）與成分（2）的重量比為上文所公開時）可用於對抗作物植物病原真菌，如鏈格孢屬，例如茄鏈格孢；白粉菌屬，例如白粉病菌； 梨孢屬，例如稻瘟病菌；殼針孢屬，例如穎枯殼針孢， 各種植物上的柄鏽屬,特別是穀物即小麥、大麥或黑麥上的葉鏽菌（褐色或葉銹病）、條鏽菌（條紋或黃鏽）、大麥柄鏽菌（矮銹病）、禾柄鏽菌（莖或黑鏽）和隱匿柄鏽菌（棕色或葉銹病）；穀類作物（如小麥、大麥或黑麥）上的禾冠柄鏽菌（包括燕麥在內的禾本科植物的冠銹病），玉米上的高粱柄鏽菌（普通銹病），玉米上的多堆柄鏽菌（南方銹病）和向日葵銹病（向日葵銹病）；黑頭鏽菌（甘蔗中的“褐銹病”）；咖啡鏽菌和咖啡灰鏽菌（咖啡葉銹病和灰銹病）；咖啡鏽菌（咖啡銹病）；各種作物上的單胞鏽菌屬；以及各種植物上的褐斑病屬，特別是大豆上的豆薯層鏽菌和山馬蝗層菌（大豆銹病）。In a preferred embodiment, the compositions disclosed in Tables 1 to 16 (especially when the weight ratio of ingredient (1) to ingredient (2) of these mixtures is disclosed above) can be used to combat crop plant pathogenic fungi, Such as Alternaria, such as Alternaria solanacearum; Powdery mildew, such as Powdery mildew ; Pyricularia, such as Pyricularia oryzae; Ascosporium, such as Needle sphaerocarpus , Puccinia spp on various plants, especially It is the leaf rust fungus (brown or leaf rust), stripe rust fungus (streak or yellow rust), barley stalk rust fungus (dwarf rust), gramineous rust fungus (stem or black rust) on grains, namely wheat, barley or rye And cryptic rust fungus (brown or leaf rust); stalk rust fungus on cereal crops (such as wheat, barley or rye) (crown rust on gramineous plants including oats), sorghum rust on corn Rust (common rust), rust (southern rust) and sunflower rust (sunflower rust) on corn; blackhead rust ("brown rust" in sugarcane); coffee rust and coffee gray rust (coffee leaf) Rust and gray rust); coffee rust fungus (coffee rust); Puccinia monocytogenes on various crops; and brown spot disease genus on various plants, especially Puccinia bean and Puccinia serrata on soybeans (Soybean rust).
本發明的新型農用化學組合物具有有效的殺微生物活性。它們可用於控制有害微生物，例如有害真菌和細菌，在作物保護中特別有用。更具體地，根據本發明的農用化學組合物可以用於保護種子、發芽植物、萌芽的幼苗、植物、植物部分、果實以及植物生長的土壤免受有害微生物侵擾。The novel agrochemical composition of the present invention has effective microbicidal activity. They can be used to control harmful microorganisms, such as harmful fungi and bacteria, and are particularly useful in crop protection. More specifically, the agrochemical composition according to the present invention can be used to protect seeds, germinated plants, germinated seedlings, plants, plant parts, fruits, and the soil where the plants grow from harmful microorganisms.
本文所用的術語“控制”包括對不需要的微生物的治療性和保護性處理。有害微生物可以是病原細菌或病原真菌，更具體地講是植物致病細菌或植物致病真菌。這些植物病原微生物是多種植物疾病的病因（下文有詳細描述）。The term "control" as used herein includes the therapeutic and protective treatment of unwanted microorganisms. The harmful microorganisms may be pathogenic bacteria or pathogenic fungi, more specifically phytopathogenic bacteria or phytopathogenic fungi. These phytopathogenic microorganisms are the cause of many plant diseases (described in detail below).
更具體地說，本發明的新型農用化學組合物可以用作殺真菌劑。尤其是用於作物保護中，例如用於控制有害真菌，如瘧原蟲、卵菌、壺菌綱、接合菌、子囊菌、擔子菌和半知菌。More specifically, the novel agrochemical composition of the present invention can be used as a fungicide. Especially used in crop protection, for example for the control of harmful fungi, such as Plasmodium, Oomycetes, Chytrid, Zygomycetes, Ascomycetes, Basidiomycetes and Deuteromycetes.
本發明的新型農用化學組合物也可以用作殺菌劑。尤其是用於作物保護中，例如用於控制有害細菌，例如假單胞菌科、根瘤菌科、腸桿菌科、棒狀桿菌科和鏈黴菌科。The novel agrochemical composition of the present invention can also be used as a fungicide. Especially used in crop protection, for example for the control of harmful bacteria such as Pseudomonas, Rhizobium, Enterobacteriaceae, Corynebacteriaceae and Streptomyces.
在一個實施方案中，本發明提供了一種控制或預防有用的植物被農作物和/或園藝作物中的植物病原性真菌侵染的方法，其中該殺真菌組合物可施用於植物、植物部分或其生長地。In one embodiment, the present invention provides a method for controlling or preventing useful plants from being infested by phytopathogenic fungi in crops and/or horticultural crops, wherein the fungicidal composition can be applied to plants, plant parts or Growing place.
在另一個實施方案中，本發明提供了對抗植物病原性真菌的方法，其包括用本文所述的殺真菌組合物處理植物、土壤、種子或待保護的材料。In another embodiment, the present invention provides a method of combating phytopathogenic fungi, which comprises treating plants, soil, seeds, or materials to be protected with the fungicidal composition described herein.
本發明還涉及控制有害微生物（例如有害真菌和細菌）的方法，其包括將至少一種本發明的新型農用化學組合物施用於微生物和/或其生境（植物、植物部位、種子、果實或植物生長的土壤））的步驟。The present invention also relates to a method for controlling harmful microorganisms (such as harmful fungi and bacteria), which comprises applying at least one of the novel agrochemical compositions of the present invention to the microorganisms and/or their habitats (plants, plant parts, seeds, fruits or plant growth). Soil)) steps.
通常，當本發明的新型農用化學組合物用於控制植物病原性真菌的治療或保護性方法中時，將有效、對植物無毒性的量施用於植物、植物部分、果實、種子或植物生長的土壤中。Generally, when the novel agrochemical composition of the present invention is used in a therapeutic or protective method for controlling phytopathogenic fungi, an effective, non-toxic amount to the plant is applied to the plant, plant part, fruit, seed or plant growth. In the soil.
有效、對植物無毒性的量是指足以控制或破壞農田上存在或易於出現的真菌，且對上述作物不產生明顯的植物毒性症狀的量。根據要控制的真菌、農作物的類型、氣候條件和所使用的本發明的各個組合物，該量可以在很寬的範圍內變化。該量可以通過本領域技術人員能力範圍內的系統性田間試驗確定。An effective and non-toxic amount to plants refers to an amount that is sufficient to control or destroy fungi that are present or prone to appear on the farmland, and does not produce obvious symptoms of phytotoxicity to the above-mentioned crops. The amount can vary within a wide range according to the fungi to be controlled, the type of crops, climatic conditions, and the various compositions of the present invention used. This amount can be determined by systematic field trials within the abilities of those skilled in the art.
本發明的新型農用化學組合物可以施用於任何植物或植物部位。The novel agrochemical composition of the present invention can be applied to any plant or plant part.
在一個實施方案中，本發明提供了用於處理種子、轉基因植物的種子和轉基因植物的殺真菌組合物。In one embodiment, the present invention provides fungicidal compositions for treating seeds, seeds of transgenic plants, and transgenic plants.
“植物”是指所有植物和植物種群，例如有益和有害的野生植物或作物植物（包括天然存在的農作物）。作物植物可以是可以通過常規育種和優化方法或通過生物技術和基因工程方法或這些方法的組合獲得的植物，包括轉基因植物以及受植物育種者的權利保護和不保護的植物栽培種。"Plants" refers to all plants and plant populations, such as beneficial and harmful wild plants or crop plants (including naturally occurring crops). Crop plants may be plants that can be obtained through conventional breeding and optimization methods or through biotechnology and genetic engineering methods or a combination of these methods, including transgenic plants and plant cultivars that are protected or not protected by the rights of plant breeders.
轉基因植物（GMO）是已經將異源基因穩定整合到基因組中的植物。從本質上來說，“異源基因”是指在植物外部提供或裝配並被引入到核、葉綠體或線粒體基因組中的基因。該基因通過表達目標蛋白質或多肽或下調或沉默植物中存在的其他基因，從而賦予轉化植物新的或改良的農藝或其他特性[例如，使用反義技術，共抑制技術，RNA干擾（RNAi）技術或microRNA（miRNA）技術]。位於基因組中的異源基因也稱為轉基因。由其在植物基因組中的特定位置定義的轉基因稱為轉化或轉基因事件。A genetically modified plant (GMO) is a plant in which a heterologous gene has been stably integrated into the genome. Essentially, a "heterologous gene" refers to a gene that is provided or assembled outside the plant and introduced into the nuclear, chloroplast, or mitochondrial genome. The gene expresses the target protein or polypeptide or down-regulates or silences other genes present in the plant, thereby imparting new or improved agronomic or other characteristics to the transformed plant [for example, using antisense technology, co-suppression technology, RNA interference (RNAi) technology Or microRNA (miRNA) technology]. A heterologous gene located in the genome is also called a transgene. A transgene defined by its specific position in the plant genome is called a transformation or transgenic event.
植物栽培種應理解為是指具有新特性（“性狀”）並通過常規育種、誘變或重組DNA技術獲得的植物。它們可以是栽培品種、變種、生物型或基因型。Plant cultivars should be understood as referring to plants that have new characteristics ("traits") and are obtained through conventional breeding, mutagenesis or recombinant DNA technology. They can be cultivars, varieties, biotypes or genotypes.
植物部位是指植物地上和地下的所有部位和器官，如芽、葉、針、莖、花、子實體、果、籽、根、塊莖、根莖等。植物部分還包括收穫的材料和營養和生殖繁殖材料（例如插條、塊莖、根莖、枝條和種子）。Plant parts refer to all the parts and organs above and below the plant, such as buds, leaves, needles, stems, flowers, fruiting bodies, fruits, seeds, roots, tubers, rhizomes, etc. Plant parts also include harvested material and vegetative and reproductive propagation material (such as cuttings, tubers, rhizomes, branches and seeds).
可根據本發明的方法處理的植物包括：棉花；亞麻；葡萄；水果；蔬菜，例如薔薇科（例如蘋果和梨等梨果，杏子、櫻桃、杏仁和桃子等核果，草莓等漿果類）；核糖菌科；胡桃科；樺木科；漆樹科；山毛櫸科；綠藻科；木犀科；獼猴桃科；樟科；芭蕉科（例如香蕉樹和人工林）；茜草科（例如咖啡）；山茶科；梧桐科；芸香料（例如檸檬、柳丁和葡萄柚）；茄科（例如番茄），百合科；菊科（例如生菜）；傘形科；十字花科；藜科；葫蘆科（例如黃瓜）；蔥科（例如韭菜、洋蔥）；鳳蝶科（例如豌豆）；主要農作物，例如禾本科（例如玉米、草皮、小麥、黑麥、大米、大麥、燕麥、小米等穀物）；菊科（例如向日葵）；十字花科（例如白菜、紅甘藍、西蘭花、花椰菜、球芽甘藍、小白菜、大頭菜、蘿蔔和油菜、芥末、辣根和水芹）；豆科（例如豆、花生）；鳳蝶科（例如大豆）；茄科（例如土豆）；藜科（例如：甜菜、飼料甜菜、瑞士甜菜、甜菜根）；用於花園和林區的有用植物和觀賞植物； 以及每種植物的轉基因品種。Plants that can be treated according to the method of the present invention include: cotton; flax; grapes; fruits; vegetables, such as Rosaceae (for example, pears such as apples and pears, stone fruits such as apricots, cherries, almonds and peaches, and berries such as strawberries); ribose Fungi; Juglans; Betulaceae; Anacardiaceae; Fagaceae; Chlorophyceae; Oleaceae; Actiniaceae; Lauraceae; Musaceae (such as banana trees and plantations); Rubiaceae (such as coffee); Camellia; Sycamore Family; Rutaceae (such as lemon, orange and grapefruit); Solanaceae (such as tomato), Liliaceae; Compositae (such as lettuce); Umbelliferae; Cruciferae; Chenopodiaceae; Cucurbitaceae (such as cucumber); Allium family (such as leeks, onions); Papilio family (such as peas); major crops, such as gramineous (such as corn, turf, wheat, rye, rice, barley, oats, millet and other grains); Compositae (such as sunflower ); Cruciferous (such as cabbage, red cabbage, broccoli, cauliflower, Brussels sprouts, Chinese cabbage, kohlrabi, radish and rape, mustard, horseradish and cress); Leguminous (such as beans, peanuts); Papilio Family (such as soybeans); Solanaceae (such as potatoes); Chenopodiaceae (such as sugar beet, fodder beet, Swiss chard, beetroot); useful plants and ornamental plants used in gardens and forest areas; and genetically modified varieties of each plant .
可以根據本發明治療的真菌病的病原體的非限制性實例包括：Non-limiting examples of pathogens of fungal diseases that can be treated according to the present invention include:
由白粉病病原體引起的疾病，例子有：布氏白粉屬，例如麥類白粉病菌；叉絲單囊殼屬屬物，例如叉絲單囊殼菌；單絲殼屬，例如，單絲殼菌；鉤絲殼屬，例如葡萄鉤絲殼菌；白粉菌屬，例如二孢白粉菌；Diseases caused by powdery mildew pathogens, examples include: Brandt powdery mildew genus, such as wheat powdery mildew; C. filamenta genus, such as C. filamenta spp.; Monofilament genus, for example, C. vulgaris ; Uncaria, such as Uncaria vitis; Powdery mildew, such as Sphaerotheca dispora;
由銹病病原體引起的疾病，例子有：膠鏽菌屬，例如褐色膠鏽菌；駝孢鏽菌屬，例如咖啡駝孢鏽菌；層鏽菌屬，例如豆薯層鏽菌或大豆鏽菌；柄鏽菌屬，例如隱匿柄鏽菌，禾柄鏽菌或條形柄鏽菌；單胞鏽菌屬，例如疣頂單孢鏽菌，Examples of diseases caused by rust pathogens are: Gum rust, such as Gum rust brown; Puccinia cylindrica, such as Puccinia esculenta; Puccinia spp., such as Puccinia bean or soybean rust; Puccinia sp
特別是松皰銹病菌（白松皰銹病）；膠鏽菌（膠鏽菌癭）；咖啡鏽菌（咖啡銹病）；層鏽菌（大豆銹病）；禾冠柄鏽菌（燕麥冠銹病和黑麥草）；禾柄鏽菌（小麥和肯塔基州早熟禾的莖銹病，或穀物的黑銹病）；黃花菜柄鏽菌（黃花菜銹病）；固隱匿柄鏽菌（小麥鏽或“棕鏽或紅鏽”）；玉米柄鏽菌（玉米鏽）；小麥條鏽菌（穀物中的黃銹病）；黑頂柄鏽菌；疣頂單孢鏽菌（豆鏽）；菜豆單胞鏽菌（豆鏽）；黑頂柄鏽菌（甘蔗中的褐銹病）；屈恩柄鏽菌（甘蔗中的黃銹病）。In particular, pine rust fungus (white pine blister rust); gum rust fungus (gluco rust gall); coffee rust fungus (coffee rust); layer rust fungus (soybean rust); gramineous rust fungus (oat crown rust and ryegrass) ); Puccinia graminearum (stem rust of wheat and Kentucky bluegrass, or black rust of grains); Puccinia spp. (day lily rust); Puccinia vulgaris (wheat rust or "brown rust or red rust" "); Corn stalk rust fungus (corn rust); wheat stripe rust fungus (yellow rust disease in grains); black acrostalk rust fungus; verrucosa rust fungus (bean rust); bean rust fungus (bean rust) ; Puccinia nigra (brown rust in sugarcane); Puccinia vulgaris (yellow rust in sugarcane).
由卵菌類病原體引起的疾病，例子有：白鏽屬，例如菜白銹病菌；盤霜黴屬，例如萵苣盤梗黴；疫黴屬，例如馬鈴薯晚疫病菌；單軸黴屬，例如霜黴病菌；假霜黴屬，例如假小孢子菌或黃瓜霜黴病菌；腐黴屬物種，例如終極腐黴屬；Diseases caused by oomycete pathogens, examples include: white rust, such as white rust pathogen; Peronospora spp., such as Pseudomonas lettuce; Phytophthora spp., such as Phytophthora infestans of potato; Monoaxial molds, such as Downy mildew Pathogens; Pseudodownon mold, such as Pseudomicrosporidium or Cucumber Downy mildew; Pythium species, such as Pythium ultimum;
葉片斑點病和枯萎病，引起這些植物疾病的菌屬的例子有：鏈格孢屬，例如番茄早疫病菌；尾孢菌屬，例如藜科尾孢菌；枝孢屬，例如黃瓜枝孢；旋孢腔菌屬，例如禾旋孢腔菌（分生孢子：內臍蠕孢屬，同長蠕孢屬）或宮部旋孢腔菌；炭疽菌屬，例如炭疽病菌；鏽斑病菌屬，例如孔雀斑病菌；間座殼屬，例如間座殼菌；痂囊腔菌屬，例如柑桔痂囊腔菌；盤長孢屬，例如桃炭疽病菌；小叢殼屬病，例如圍小叢殼菌；球座菌屬，例如葡萄球座菌；小球腔黴屬，例如十字花科小球腔菌；稻瘟病菌屬，例如稻瘟病菌；微座孢屬，例如微座孢屬斑病菌；球腔菌屬，例如禾生球腔菌，落花生球腔菌或斐濟球腔菌；暗球腔菌屬，例如穎枯殼針孢；核腔菌屬，例如圓核腔菌或偃麥草核腔菌；柱隔孢屬；喙孢屬，例如大麥雲紋病菌；殼針孢屬，例如殼針孢菌；殼多孢屬，例如穎枯殼多孢；核瑚菌屬，例如肉孢核瑚菌；黑星菌屬，例如蘋果黑星病；Leaf spot disease and fusarium wilt, examples of the genus that cause these plant diseases are: Alternaria, such as early blight of tomato; Cercospora, such as Cercospora chinensis; Cladosporium, such as Cucumber Cladosporium; Trichosporium spp., such as Trichosporium graminearum (conidia: Bipolaris spp., the same genus Helminthosporium) or Trichosporium uteri; Colletotrichum genus, such as Colletotrichum gloeosporioides; Rusty spotted bacteria, such as peacock Phytophthora sp ; Coccidia, such as Staphylococcus; Microsphaeropsis, such as Cruciferae, Micrococcus; Magnaporthe spp, such as Magnaporthe grisea; Microsporium, such as Microsporum sphaeroides; Sphaeropsis genus, such as Sphaeropsis graminearum, Sphaeropsis arachis, or Sclerotia fiji; Sclerotomycetes, such as Sclerotium solanacearum; Sclerotomycetes, such as Sclerotium rotundus or Rhizoctonia solani ; Cylindrosporium; Ceratosporium, such as Barley Moss; Ascosporium, such as Ascosporium; Ascopolysporium, such as Sclerotium; Sclerotium, such as Sarcosporium ; Venturia, such as apple scab;
根莖疾病，引起這些植物疾病的菌屬的例子有：伏革菌屬，例如由禾伏革菌；鐮刀菌屬，例如尖孢鐮刀菌；頂囊殼屬，例如，小麥全蝕病菌；根腫屬，例如根腫菌；絲核菌屬，例如立枯絲核菌；帚枝黴屬，例如鞘腐敗病菌；小菌核屬，例如小球菌核菌；Tapesia 屬，例如Tapesia acuformis 梭狀芽胞桿菌 ；根串珠黴屬，例如菫菜根腐病菌；靈芝屬，例如靈芝；Rhizome diseases, examples of the genus of bacteria that cause these plant diseases are: Accumbens, for example, Fusarium graminearum; Fusarium, for example, Fusarium oxysporum; Acrocystis, for example, wheat rot; rhizoma genus, e.g. clubroot bacteria; Rhizoctonia, eg Rhizoctonia solani; broom branches Rhizopus, bacteria e.g. corruption sheath; sclerotium genus, e.g. Pediococcus scleroglucan; Tapesia spp., Clostridium Tapesia acuformis e.g. ; Leuconostoc, such as Root Rot Pathogen of Swamp Cabbage; Ganoderma, such as Ganoderma lucidum;
穗病（包括玉米芯），引起這種植物疾病的菌屬的例子有：鏈格孢屬，例如鏈格孢菌；麯黴屬，例如黃麴黴；枝孢屬，例如枝狀枝孢菌；麥角菌屬，例如黑麥麥角菌；鐮刀菌屬，例如鐮刀菌；赤黴菌屬，例如玉米赤黴菌；明梭孢屬，例如雪腐明梭孢；殼針孢屬，例如穎枯殼多孢；Ear diseases (including corn cobs). Examples of the genus that cause this plant disease are: Alternaria, such as Alternaria; Aspergillus, such as Aspergillus flavus; Cladosporium, such as Cladosporium; Ergot genus, such as Ergot ryegrass; Fusarium genus, such as Fusarium; Gibberella genus, such as Gibberella zea; Polyspore
由黑穗病真菌引起的疾病，這種黑穗病真菌的例子有：軸黑粉菌屬，例如絲軸黑粉菌；腥黑粉菌屬，例如小麥網腥黑穗病菌或小麥矮腥黑穗病；條黑粉菌屬，例如隱條黑粉菌；黑粉菌屬，例如裸黑粉菌；Diseases caused by smut fungi. Examples of such smut fungi are: Smut fungus, such as Smut fungus; Tilletia, such as Tilletia grisea or Tilletia vulgaris Ear disease; smut fungus, such as smut fungus; smut fungus, such as smut;
水果腐爛，引起這種植物疾病的菌屬的例子有：例如麯黴屬，例如黃麴黴；葡萄孢屬，例如灰葡萄孢；青黴菌屬，例如擴展青黴菌或紫青黴菌；根黴屬，例如根莖根黴；核盤菌屬，例如核盤菌核盤菌；輪枝孢屬，例如黑白輪枝孢；Fruit rot, examples of the genus causing this plant disease are: for example, Aspergillus, such as Aspergillus flavus; Botrytis, such as Botrytis cinerea; Penicillium, such as Penicillium dilatatum or Penicillium purpurea; Rhizopus, For example Rhizopus rhizome; Sclerotinia, such as Sclerotinia sclerotiorum; Verticillium, such as Verticillium black and white;
種子和土壤傳播的腐爛和枯萎病以及幼苗疾病，引起這種植物疾病的菌屬的例子有：鏈格孢屬，例如生鏈格孢菌；絲囊黴屬，例如根腐絲囊黴；殼二孢屬，例如晶狀殼二孢；麯黴屬，例如黃麴黴；枝孢菌屬，例如，臘葉芽枝黴；旋孢腔菌屬，例如禾旋孢腔菌（分生孢子形式：內臍蠕孢屬，平臍蠕孢屬：長蠕孢黴）；炭疽菌屬，例如辣椒炭疽病菌；鐮刀菌種類，例如黃色鐮刀菌；赤黴菌屬，例如玉米赤黴菌；殼球孢屬，例如殼球孢菌；微座孢屬，例如微座孢屬斑病菌；小畫線殼屬，例如，雪腐小畫線殼；青黴菌屬，例如擴展青黴菌；莖點黴屬，例如黑脛莖點黴；擬莖點黴屬，例如大豆擬莖點菌；疫黴屬，例如惡疫黴菌；核腔菌屬，例如麥類核腔菌；稻瘟病菌種，例如稻瘟病菌；腐黴屬，例如終極腐黴菌；絲核菌屬，例如立枯絲核菌；根黴屬物種，例如米根黴；小菌核屬，例如小核菌；殼針孢屬，例如穎枯殼針孢；核瑚菌屬，例如肉孢核瑚菌；黃萎病屬，例如大麗輪枝菌；Rot and wilt diseases spread by seeds and soil, and seedling diseases. Examples of the genera that cause such plant diseases are: Alternaria, such as Alternaria sp Dispora, for example Ascodia crystalline; Aspergillus, for example, Aspergillus flavus; Cladosporium, for example, Cladosporium cereus; Helminthosporium, Helminthosporium: Helminthosporium longum); Anthrax, such as Capsicum anthracnose; Fusarium species, such as Fusarium flavum; Gibberella, such as Gibberella zeae; Conchococcus, such as Ascosporum; Microsaporium, for example, Microsaporium sphaerocarpa; Minus spp., for example, snow rot; Penicillium, for example, Penicillium dilatatum; Phoma, for example, Blackshank Phoma; Phoma, such as Phoma soja; Phytophthora, such as Phytophthora; Sclerotium, such as Sclerotium triticum; Rice blast species, such as Pythium oryzae; Pythium Genera, such as Pythium ultimum; Rhizoctonia, such as Rhizoctonia solani; Rhizopus species, such as Rhizopus oryzae; Sclerotium, such as Sclerotium; Ascosporium, such as Sclerotium solani ; Sclerotium, such as Sarcocystis sclerotium; Verticillium, such as Verticillium dahlia;
癌症、膽囊和簇葉病，引起這些植物疾病的菌屬的例子有：叢赤殼屬，例如仁果幹癌叢赤殼菌；Cancer, gallbladder and cluster leaf diseases. Examples of the genus that cause these plant diseases include the genus Rhodophyllum, such as Rhodotorium pelocarcinoma;
枯萎病，引起這種植物疾病的菌屬的例子有：鏈核盤菌屬，例如核果鏈核盤菌；Fusarium wilt, examples of the genus that cause this plant disease include: Streptococcus, such as Streptococcus drupe;
葉、花和果實的變形，引起這些變形的菌屬的例子有：外擔菌屬，例如茶餅病菌；外囊菌屬，例如畸形外囊菌；Deformation of leaves, flowers, and fruits. Examples of bacteria that cause these deformations are: Exobasidiomycetes, such as Teacake pathogens; Exocystis, such as Exocystis teratophytes;
木本植物中的退化性疾病，引起這些退化性疾病的菌屬的例子有：依科屬，例如厚垣孢普可尼亞菌，嗜鹼芽孢桿菌或地中海嗜藍孢孔菌；靈芝屬，例如島靈芝；Degenerative diseases in woody plants. Examples of the genera that cause these degenerative diseases are: according to the family genus, such as Chlamydomonas Puconia, Alkalophilic Bacillus or Cyanoporus Mediterranean; Ganoderma, For example, Ganoderma lucidum;
花朵和種子疾病，引起這些疾病的菌屬的例子有：葡萄孢屬，例如灰黴病菌；Flower and seed diseases. Examples of bacteria that cause these diseases are: Botrytis, such as Botrytis;
植物塊莖病，引起這種疾病的菌屬的例子有：絲核菌屬，例如立枯絲核菌；長蠕孢屬，例如茄病長蠕孢；Plant tuber diseases, examples of the genera that cause this disease are: Rhizoctonia, such as Rhizoctonia solani; Helminthosporium, such as Helminthosporium solanacearum;
由細菌病原體引起的疾病，這種細菌病原體的例子有：例如黃單胞菌屬，例如野油菜黃單孢菌水稻、黃單胞菌；假單胞菌屬，例如丁香假單胞菌、黃瓜細菌角斑病；歐文氏菌屬，例如解澱粉歐文氏菌；羅爾斯通菌屬，例如青枯雷爾氏菌；Diseases caused by bacterial pathogens. Examples of such bacterial pathogens are: for example, Xanthomonas, such as Xanthomonas campestris, rice, Xanthomonas; Pseudomonas, such as Pseudomonas syringae, cucumber Bacterial angular leaf spot; Erwinia, such as Erwinia amylovora; Ralstonia, such as Ralstonia solanacearum;
根和莖基部的真菌病，引起這些疾病的菌屬的例子有：黑根腐爛、木炭腐爛（殼球孢菌）、鐮刀菌枯萎病或萎蔫病、根腐病以及莢果腐病和頸腐病（尖孢鐮孢、尖角鐮刀菌、半裸鐮刀菌、木賊鐮刀菌）、巨座殼科根腐病（蒺藜巨座殼科）、新赤殼屬（新赤殼）、豆莢和莖枯萎病（大豆莖潰瘍病菌）、莖萎病（菜豆間座殼）、疫腐病（大雄疫黴）、大豆莖褐腐病（大豆莖褐腐病菌）、綿腐病（瓜果腐黴菌、畸雌腐黴、德巴厘腐黴、群結腐黴、終極腐黴菌）、絲核菌根腐病、莖腐爛和幼苗或插枝的腐爛（立枯絲核菌）、菌核莖腐爛（核盤菌）、菌核白絹病（白絹病菌）、根串珠黴根腐病（根串珠黴）。Root and stem base fungal diseases. Examples of bacteria that cause these diseases are: black root rot, charcoal rot (conchococcus), Fusarium wilt or wilt, root rot, pod rot and neck rot (Fusarium oxysporum, Fusarium oxysporum, Fusarium seminude, Fusarium equisetum), Root rot of the giant shell family (Fusarium terrestris), New red shell (new red shell), pod and stem blight (Soybean Stem Canker), Stem Wilt (Phytophthora macrocarpa), Brown Rot of Soybean Stem (Brown Rot of Soybean Stem), Sponge Rot (Pythium aurantium, Abnormal Female) Pythium, Pythium debali, Pythium solani, Pythium ultimum), Rhizoctonia root rot, stem rot and rot of seedlings or cuttings (Rhizoctonia solani), Sclerotium stem rot (Sclerotium ), Sclerotium sclerotium (Sclerotium sclerotium), Root Root Rot (Sclerotium rhizome).
可以根據本發明處理的植物包括：薔薇科（例如蘋果、梨、杏子、櫻桃、杏仁和桃子等梨果實），核科，胡桃科，樺木科、漆樹科、山毛櫸科、桑科、木犀科、樟科、芭蕉科（例如香蕉樹和人工林），茜草科（例如咖啡）、茶科、梧桐科、芸香科（例如檸檬、柳丁和葡萄柚）；葡萄科（例如葡萄）；茄科 （例如番茄，辣椒）、百合科、菊科（例如生菜）、傘形科、十字花科、藜科、葫蘆科（例如黃瓜）、蔥科（例如韭菜、洋蔥）、蝶形花科（例如豌豆）；主要農作物、例如禾本科/穎花科（例如玉米、草皮、小麥、黑麥、大米、大麥、燕麥、小米和黑小麥等穀物）、菊科（例如向日葵）、十字花科（例如白菜、紅甘藍、西蘭花、花椰菜、抱子甘藍、小白菜、大頭菜、蘿蔔和油菜、芥菜、辣根和水芹）、豆科（例如豆子、花生）、蝶形花科（例如大豆）、茄科（例如土豆）、藜科（例如甜菜、飼料甜菜、瑞士甜菜、甜菜根）；錦葵科（例如棉花）；用於花園和林區的有用植物和觀賞植物；以及每種植物的轉基因品種。Plants that can be treated according to the present invention include: Rosaceae (for example, pear fruits such as apples, pears, apricots, cherries, almonds and peaches), nuclear family, Juglans family, birch family, anacardiaceae, beech family, moraceae, oleaceae, Lauraceae, Musaceae (e.g. banana trees and plantations), Rubiaceae (e.g. coffee), Tea family, Parasolaceae, Rutaceae (e.g. lemon, orange and grapefruit); Grape family (e.g. grapes); Solanaceae (e.g. grapes) For example, tomato, pepper), Liliaceae, Compositae (e.g. lettuce), Umbelliferae, Cruciferae, Chenopodiaceae, Cucurbitaceae (e.g. cucumber), Allium family (e.g. leeks, onions), Papilionaceae (e.g. pea) ); major crops, such as gramineous/spikelets (such as corn, turf, wheat, rye, rice, barley, oats, millet and triticale), asteraceae (such as sunflower), cruciferous (such as cabbage) , Red cabbage, broccoli, cauliflower, Brussels sprouts, pakchoi, kohlrabi, radish and rapeseed, mustard, horseradish and cress), legumes (such as beans, peanuts), butterfly flowers (such as soybeans), eggplant Family (such as potatoes), Chenopodiaceae (such as sugar beet, fodder beet, Swiss chard, beetroot); Malvaceae (such as cotton); useful plants and ornamental plants used in gardens and forests; and genetically modified varieties of each plant .
更優選的是控制以下大豆疾病：葉、莖、豆莢和種子上的真菌病，例如，鏈格孢屬葉斑病（鏈格孢菌，特別是細極鏈格孢菌），炭疽病（赤葉枯刺盤孢菌、黑線炭疽菌、平頭刺盤孢），褐斑病（黑斑病），尾孢菌屬葉斑和枯萎病（菊池尾孢菌），笄黴屬葉枯病（笄黴菌屬），dactuliophora葉斑病（Dactuliophora glycines），霜黴病（東北霜黴），內臍蠕孢屬葉斑病(Drechslera glycini )，灰斑病（大豆灰斑病菌），豆科牧草小光殼葉斑病（花生焦斑病菌），phyllostica葉斑病（大豆生葉點黴），豆莢和莖枯萎枯萎病（大豆擬莖點菌），白粉病（擴散叉絲殼），棘殼孢葉斑病，氣生根黴病、葉枯病和網枯病（立枯絲核菌），銹病（豆薯層鏽菌，山馬蝗層菌），瘡痂病（大豆痂圓孢），匍柄黴屬（蔥葉枯匍柄黴），靶斑病（多主棒孢黴）。It is more preferable to control the following soybean diseases: fungal diseases on leaves, stems, pods and seeds, for example, Alternaria leaf spot (Alternaria, especially Alternaria tenuis), anthracnose (Alternaria tenuis) Colletotrichum gloeosporioides, Colletotrichum gloeosporioides, Colletotrichum gloeosporioides), brown spot (black spot), Cercospora leaf spot and wilt (Cercospora chrysanthemum), leaf blight ( (Dactuliophora glycines), dactuliophora leaf spot (Dactuliophora glycines), downy mildew (Ponospora northeast), Bipolaris spp (Drechslera glycini ), gray spot (Soybean gray spot), legume small Leaf spot disease (Peanut scorch), phyllostica leaf spot (Soybean leaf spot mold), Pod and stem wilt (Phoma soya bean), Powdery mildew (Diffuse sphagnum), Acanthophyllum leaf Spot disease, aerial rhizopus, leaf blight and net blight (Rhizoctonia solani), rust disease (Puccinia rotundifolia, Puccinia sylvestris), Scab (Soybean scab), Stalk mold The genus (Spionium solanacearum), target spot disease (Corynespora polysporum).
本發明的農用化學組合物可以用於治療性地或保護/預防性地控制植物病原性真菌。因此，本發明還涉及通過使用新型農用化學組合物治療性地和保護性地防治植物病原性真菌的方法，所述新型農用化學組合物被施用於種子、植物或植物部分、果實或植物所生長的土壤。The agrochemical composition of the present invention can be used to curatively or protect/preventively control phytopathogenic fungi. Therefore, the present invention also relates to a method for therapeutically and protectively controlling phytopathogenic fungi by using a new agrochemical composition which is applied to seeds, plants or plant parts, fruits or plants grown Soil.
在控制植物病害所需的濃度下本發明的植物對本發明的新型農用化學組合物具有良好的耐受性，這一事實使得可以對植物的地上部分、繁殖莖和種子以及土壤進行處理。The plant of the present invention has good tolerance to the novel agrochemical composition of the present invention at the concentration required to control plant diseases, and this fact makes it possible to treat the aerial parts of the plant, the propagation stems and seeds, and the soil.
根據本發明，所有植物和植物部分都可以是處理物件。植物是指所有植物和植物種群，例如有益和有害的野生植物、栽培品種和植物變種（無論是否受植物品種或植物育種者權利的保護）。栽培品種和植物變種可以是通過常規繁殖和育種方法獲得的植物，這些方法可以通過一種或多種生物技術方法來輔助或補充，例如使用雙單倍體、原生質體融合、隨機和定向突變、分子或基因標記或通過生物工程和基因工程方法。植物部位是指植物地上和地下的所有部位和器官，如芽、葉、針、莖、花、子實體、果、籽、根、塊莖、根莖等。收穫的作物和營養和生殖繁殖材料（例如插條、塊莖、根莖、枝條和種子）也是植物部分的範圍。According to the present invention, all plants and plant parts can be treated objects. Plants refer to all plants and plant populations, such as beneficial and harmful wild plants, cultivars and plant varieties (regardless of whether they are protected by plant varieties or plant breeders' rights). Cultivars and plant varieties can be plants obtained by conventional propagation and breeding methods, which can be assisted or supplemented by one or more biotechnological methods, such as the use of double haploids, protoplast fusion, random and directed mutations, molecular or Genetic markers or through bioengineering and genetic engineering methods. Plant parts refer to all the parts and organs above and below the plant, such as buds, leaves, needles, stems, flowers, fruiting bodies, fruits, seeds, roots, tubers, rhizomes, etc. Harvested crops and vegetative and reproductive propagation materials (such as cuttings, tubers, rhizomes, shoots and seeds) are also part of the plant.
當本發明的新型農用化學組合物具有良好的植物耐受性、良好的恒溫毒性和環境耐受性時，它們適用於保護植物和植物器官、提高收穫產量、提高收穫材料的品質。它們可以優選用作農作物保護組合物。它們對敏感和耐藥的物種和發育的全部或某些階段都有活性。When the new agrochemical compositions of the present invention have good plant tolerance, good constant temperature toxicity and environmental tolerance, they are suitable for protecting plants and plant organs, increasing harvest yield, and improving the quality of harvested materials. They can preferably be used as crop protection compositions. They are active against sensitive and resistant species and all or some stages of development.
可根據本發明處理的植物包括以下主要作物植物：玉米、大豆、苜蓿、棉花、向日葵、芸苔屬油籽，例如甘藍型油菜（油菜籽）、蕪菁、印度芥菜（例如（田間）芥末）和衣索比亞油菜、檳榔科植物（例如油棕、椰子）、水稻、小麥、甜菜，甘蔗、燕麥、黑麥、大麥、小米和高粱、小黑麥、亞麻、堅果、葡萄和藤蔓，以及各種植物類群的各種水果和蔬菜，例如薔薇科植物（例如，蘋果和梨等梨果，以及杏子、櫻桃、杏仁、李子和桃子等核果，以及草莓、覆盆子、紅色和黑醋栗和醋栗等漿果）、茶簏子科植物、核桃科植物、樺木科植物、漆樹科植物、殼鬥科植物、桑科植物、木犀科植物（例如橄欖樹）、獼猴桃科植物、樟科植物（例如鱷梨、肉桂、樟腦）、芭蕉科植物（例如香蕉樹和人工林）、茜草科植物（例如咖啡）、山茶科植物（例如茶）、梧桐科植物、芸香科植物（如檸檬、柳丁、柑橘和葡萄柚）；茄科植物（如番茄、土豆、胡椒、辣椒、茄子、煙草）、百合科植物、菊科植物（例如萵苣、朝鮮薊和菊苣——包括根菊苣、菊苣或普通菊苣）、傘形科植物（例如胡蘿蔔、歐芹、芹菜和塊根芹）、葫蘆科植物（例如黃瓜-包括小黃瓜、南瓜、西瓜、葫蘆和甜瓜）、蔥科植物（例如韭菜和洋蔥）、十字花科植物（例如白捲心菜、紅捲心菜、西蘭花、花椰菜、球芽甘藍、小白菜、大頭菜、蘿蔔、辣根、水芹和大白菜）、豆科植物（例如花生、豌豆、扁豆以及普通豆和蠶豆等豆類）、藜蘆科植物（例如瑞士甜菜、飼料甜菜、菠菜、甜菜根）、亞麻科植物（例如大麻）、大麻科植物（例如大麻）、錦葵科植物（例如秋葵、可哥）、罌粟科（例如罌粟）、蘆筍科（例如蘆筍）；花園和樹林中有用植物和觀賞植物，包括草皮、草坪、草和甜葉菊；以及每種情況下這些植物的轉基因類型。Plants that can be treated according to the present invention include the following major crop plants: corn, soybean, alfalfa, cotton, sunflower, Brassica oilseeds, such as Brassica napus (rapeseed), turnips, Indian mustard (such as (field) mustard) and Ethiopian rapeseed, areca plants (such as oil palm, coconut), rice, wheat, sugar beet, sugar cane, oats, rye, barley, millet and sorghum, triticale, flax, nuts, grapes and vines, and various Various fruits and vegetables of the plant group, such as Rosaceae (for example, pear fruits such as apples and pears, and stone fruits such as apricots, cherries, almonds, plums, and peaches, as well as strawberries, raspberries, red and black currants, and gooseberries, etc. Berries), Camellia plants, Walnut plants, Birch plants, Lacqueaceae, Fagaceae, Moraceae, Oleaceae (such as olive trees), Actinidia, Lauraceae (such as avocado) , Cinnamon, camphor), Musaceae plants (such as banana trees and plantations), Rubiaceae plants (such as coffee), Camellia plants (such as tea), Sycamore plants, Rutaceae plants (such as lemons, oranges, citrus, and Grapefruit); Solanaceae (such as tomato, potato, pepper, pepper, eggplant, tobacco), Liliaceae, Compositae (such as lettuce, artichoke and chicory-including root chicory, chicory or common chicory), umbrella Shaped plants (such as carrots, parsley, celery, and celeriac), cucurbits (such as cucumbers-including cucumbers, pumpkins, watermelons, gourds and melons), allium plants (such as leeks and onions), cruciferous plants (Such as white cabbage, red cabbage, broccoli, cauliflower, Brussels sprouts, pakchoi, kohlrabi, radish, horseradish, cress and Chinese cabbage), legumes (such as peanuts, peas, lentils, common beans and broad beans, etc.) Legumes), Veratrum plants (such as Swiss chard, fodder beet, spinach, beetroot), flax plants (such as hemp), cannabis plants (such as hemp), malvaceous plants (such as okra, coco), Papaveraceae (for example, poppy), Asparagus (for example, asparagus); useful plants and ornamental plants in gardens and woods, including turf, lawn, grass, and stevia; and the genetically modified types of these plants in each case.
特別地，根據本發明的新型農用化學組合物適於控制以下植物病害：In particular, the novel agrochemical composition according to the present invention is suitable for controlling the following plant diseases:
觀賞植物、蔬菜(如念珠菌)和向日葵(如金龜子甲)上的(白銹病)；蔬菜、油菜(油菜或芸苔)、甜菜(細鏈格孢)、水果、大米、大豆、馬鈴薯(如龍葵鏈格孢)、番茄(如龍葵鏈格孢)和小麥上的鏈格孢屬；在甜菜和蔬菜上殼二胞菌；穀物和蔬菜上的絲囊黴菌，例如，小麥上的小麥赤黴病(炭疽病)和大麥上的黑麥赤黴病；蠕孢黴和內臍蠕孢屬(異形體：旋孢腔菌屬)，例如玉米/穀物上的南方葉枯病(玉米灰斑病菌)或玉米大斑病（玉米圓斑病菌），例如穀物上的葉斑病（麥根腐病）和稻穀和草皮上的稻瘟病；在穀類作物（例如小麥或大麥）的白粉病菌（以前是白粉菌）禾本科植物（白粉病）；在水果和漿果（例如草莓）、蔬菜（如萵苣、胡蘿蔔、芹菜和捲心菜）、油菜、花卉、葡萄、林業植物和油菜上的灰黴病菌（異形體：灰葡萄孢黴：灰色黴菌）小麥；萵苣上的霜黴病；闊葉樹和常綠植物上的長喙殼，例如榆樹上的尺蠖（荷蘭榆病）；在玉米上（例如灰斑：玉米-玉米斑病）、大米、甜菜（例如檳榔）、甘蔗、蔬菜、咖啡、大豆（例如大豆斑病）菊苣）和大米上的紫斑病；番茄和和穀類上的枝孢黴（例如葉黴），例如小麥上的草莖點黴（黑穗）；穀物上的麥角菌（麥角）；玉米（玉米圓斑病菌）、穀類（例如圓葉槐，異形體：根腐病菌）和水稻（例如葉斑病，異形體：稻瘟病）的旋孢腔菌（異形體：兩極線蟲）；在棉花、玉米（例如大草鶯屬：炭疽病莖腐爛）、軟水果、馬鈴薯（例如炭疽病菌：黑點）、豆類（例如豆刺盤孢）和大豆（例如平頭刺盤孢或膠孢炭病菌）上的炭疽菌（異形體：小叢殼屬）（炭疽病）；大米上的伏革菌屬，例如紋枯病（鞘枯病）；大豆和觀賞植物上的葉斑；橄欖樹上的雀斑病；果樹、葡萄藤（例如鵝掌藤屬，有性型，黑腳病）和觀賞植物上的柱孢屬（果樹潰瘍病或幼年藤蔓衰退，異形體：壞死或初生孢子）；大豆上的脫毒植物（變形蟲：薔薇屬）壞死菌（根和莖腐爛）；大豆上的菜豆輪斑病菌；玉米、穀物如大麥（如圓柱菌、網斑病）和小麥（如小麥：褐斑病）、大米和草坪上的內臍蠕孢屬（蠕蟲孢子，遠距形成層:核孔蟲）；葡萄藤上由蟻生（層孔菌）、馬鞭草、地黃、厚垣褐指藻(早熟的厚垣褐指藻)、嗜綠指藻和/或鈍頂芽孢桿菌引起的回枯；梨果、軟果(炭疽病)和藤本植物(炭疽病)上的痂囊腔菌屬病；稻子上的稻黑腫病；小麥黑黴病；甜菜（甜菜黑黴病）、蔬菜（如豌豆），如葫蘆（如菊苣）、捲心菜、油菜（如十字花科植物）上的白粉病；果樹、藤蔓和觀賞林上的白樺上的頂枯病（無性潰瘍或枯梢病，無性生殖：胞孢菌。瞼球菌）；在玉米（例如薑黃）上的寄生蟲；各種植物上的鐮刀菌（萎蔫、根腐或莖腐），如穀類（例如小麥或大麥）上的禾本科或倉鼠（根腐、痂或頭疫），番茄上的氧化孢子菌，茄上的茄子枯萎病菌（現為甘氨酸桿菌）。病毒型和圖庫曼原蟲和巴西原蟲分別在大豆上引起猝死綜合症，和玉米上引起輪狀芽孢桿菌；禾穀類作物(如小麥或大麥)和玉米上引起禾本科芽孢桿菌；在穀類作物上（如玉米屬）和水稻上（巴卡那病）的赤黴菌屬；葡萄、柚子和其他植物上的扣帶小球藻；棉花上的棉鈴蟲；水稻上的禾本科複合體；葡萄上的吉格納氏菌（黑腐病）；薔薇科植物和杜松上的裸子孢子菌，例如梨上的莎比納（鏽菌）；玉米、穀物和水稻上的蠕蟲孢子菌；咖啡上的駝孢鏽菌屬，如咖啡鏽菌（咖啡葉鏽）；葡萄騰上的枝孢黴；大豆和棉花上的巨噬細胞病（根和莖腐爛）；穀類（例如小麥或大麥）上的小孢子菌（粉色雪黴）；大豆上的小孢子菌（白粉病）；結石水果和其他薔薇科植物上的鏈核盤菌屬，例如開花和嫩枝枯萎病，褐腐病；在穀類、香蕉、軟水果和碎堅果上的葉斑病，比如小麥上的麥粒可樂（變形體：小麥紋枯病菌，殼針孢葉斑病）或香蕉上的斐濟黴菌（黑穗病）；甘藍（例如甘藍）、油菜（例如寄生蟲）、洋蔥（例如破壞磷）、煙草（煙粉虱）和大豆（例如滿洲青黴）上的霜黴屬（霜黴）；大豆上的大豆鏽；葡萄上（如氣管線蟲）和大豆（如灰黴莖腐病）的瓶黴屬；油菜和捲心菜上的根朽病（根腐和莖腐），甜菜上的蛇眼病菌（根腐、葉斑和阻尼）；向日葵、葡萄藤（葡萄霜黴病和葉斑病）和大豆（莖腐病：赤小豆，有性型：大豆莖潰瘍病菌）上的擬莖點黴屬；玉米上的麥芽疫黴（褐斑）；各種植物上的疫黴（枯萎病、根、葉、果和莖根），如辣椒和葫蘆（如辣椒疫黴），大豆（如巨豆疫黴，同源物）大豆疫黴、馬鈴薯和番茄(例如晚疫病)和闊葉樹(例如櫟樹疫黴：突然死亡)；甘藍、油菜、蘿蔔和其他植物上的甘藍(球根)瘧原蟲；等離子體寄生蟲，例如葡萄上的玻璃體瘧原蟲(葡萄霜黴)，向日葵上的哈氏瘧原蟲；薔薇科植物、酒花、石榴和軟果上的叉絲單囊殼屬(白粉病)，例如蘋果上的白背飛虱；多黏菌，例如穀類，如大麥和小麥(多黏菌)和甜菜(甜菜蛇眼病)和傳播病毒病；禾穀類，如小麥或大麥上的假小尾孢屬；各種植物上的假單孢菌（霜黴病），如葫蘆上的楔形芽孢桿菌或啤酒花上的腐黴；在葡萄上氣管假單孢菌（紅火病或輪蟲病，變形體：瓶黴屬）；各種植物上的柄鏽菌屬（鏽），例如小麥（棕色或葉鏽）、條鏽菌（條鏽或黃鏽）、矮生銹菌（矮生銹）、禾本科鏽菌（莖或黑鏽）或禾本科鏽菌（褐色或葉鏽），例如小麥、大麥或黑麥、甘蔗和蘆筍上屈恩柄鏽菌（橙鏽）；小麥上的焦粒病菌（變形體：內臍蠕孢屬），小麥赤黴病菌（褐斑病）或大麥上的赤黴病菌（網斑病）；稻穀上的稻瘟病菌（遠形：稻瘟）和大米上的稻瘟病菌（稻瘟），草坪、水稻、玉米、小麥、棉花、葡萄、向日葵、大豆、甜菜、蔬菜和各種其他植物(例如極致疫黴或無疫黴)上的稻瘟病菌（阻尼）；柱隔孢屬，如大麥上的葉斑（生理葉斑）和甜菜上的灰白斑長隔孢黴；棉花、水稻、馬鈴薯、草坪、玉米、油菜、馬鈴薯、甜菜、蔬菜以及各種其他植物上的絲核菌屬，例如大豆上的立枯絲核菌(根莖腐爛)、水稻上的立枯絲核菌(紋枯病)或小麥或大麥上的麥子紋枯病(紋枯病)；黑黴、胡蘿蔔、捲心菜、藤蔓和番茄上的匍匐根黴(黑黴、軟腐病)；大麥、黑麥和小黑麥上的大麥雲紋病菌(燙傷)樣；水稻上的稻瘟病菌和稀疏鏈球菌(鞘腐)；蔬菜和大田作物上的菌核病菌(莖腐或白黴)，如油菜、向日葵(例如菌核病菌)和大豆(例如羅氏菌核病菌)；各種植物上的殼針孢屬，如大豆上的甘氨酸鏈球菌（褐斑）、小麥上的小麥斑點桿菌（殼針孢斑點葉枯病）和穀物上的殼多胞菌屬；葡萄藤上的鉤絲殼屬（變形體：白粉病）和板口線蟲屬（白粉病，無性型：粉孢屬）；玉米（如薑黃，同源異株：葉蠕孢菌）和草坪上的葉枯病菌；玉米（如玉米絲黑穗病菌：絲黑穗病）、高粱和甘蔗上的軸黑粉菌屬（黑穗病）；葫蘆上的球形孢菌（粉狀黴）；馬鈴薯上的海綿孢菌（粉狀疥瘡），從而傳播病毒疾病；穀物類上的殼多胞菌屬，如小麥上的穎枯殼針孢（殼多胞菌屬，有性型：小球腔菌屬）[異形體：鉤端螺旋體]；馬鈴薯上的內生合胞體（馬鈴薯疣病）；例如桃上的變形桿菌（葉捲曲病）和李子上的李外囊菌（李袋）；煙草、柚子、蔬菜、大豆和棉花上的根串珠黴（黑根腐爛），例如根黑腐病（變形體：雅致暗內孢）；穀物上的腥黑粉菌屬（普通茴香或臭黑穗病），如小麥上的小麥腥黑粉菌（異形體.小麥光腥黑穗病)和小麥矮腥黑穗病菌(矮腥黑穗病)；大麥或小麥上的肉孢核瑚菌（灰雪黴病）；條黑粉菌屬，如黑麥上的莖黑穗病；蔬菜，如豆類（菜豆鏽菌）和甜菜上的單胞鏽菌屬(銹病）；穀物類（如，黑穗病)、玉米(如，玉米黑粉菌：玉米黑穗病)和甘蔗上的黑粉菌屬；蘋果(如，黑星病)和梨上的黑星菌屬(瘡痂病)；以及各種植物，如水果、觀賞植物、葡萄藤、軟性水果、蔬菜和大田作物上的黃萎病(枯萎病)，例如草莓、油菜、馬鈴薯和番茄上的大麗輪枝菌。(White rust) on ornamental plants, vegetables (such as Candida) and sunflowers (such as beetles); vegetables, rape (cole or brassica), beets (Alternaria tenuis), fruits, rice, soybeans, potatoes (such as Alternaria solani), Alternaria solani), tomatoes (such as Alternaria solani), and Alternaria spp on wheat; Diaspora on sugar beets and vegetables; Mycelial fungus on grains and vegetables, for example, wheat on wheat Head blight (anthracnose) and rye head blight on barley; Bipolaris and Helminthosporium (Heteromorph: Trichomonas), such as southern leaf blight on corn/cereals (corn ash) Rhizoctonia solani) or corn leaf spot (Rhizoctonia solani), such as leaf spot on cereals (wheat root rot) and rice blast on rice and turf; powdery mildew in cereal crops (such as wheat or barley) ( Formerly powdery mildew) gramineous plants (powdery mildew); Botrytis cinerea ( Alien bodies: Botrytis cinerea: Gray mold) wheat; downy mildew on lettuce; long beak shells on broad-leaved trees and evergreen plants, such as loopers on elm trees (Dutch elm disease); on corn (eg gray spot: Purple spot on corn-corn spot), rice, sugar beet (such as betel nut), sugar cane, vegetables, coffee, soybeans (such as soybean spot, chicory) and rice; Cladosporium on tomatoes and cereals (such as leaf mold) ), such as Phoma sphaeroides on wheat (black ears); ergot (ergot) on grains; corn (round leaf spot fungus), cereals (such as locust tree, heteromorph: root rot fungus) and rice (E.g. leaf spot, alien: rice blast) Trichosporium (alien: bipolar nematode); in cotton, corn (e.g. warbler: anthracnose stem rot), soft fruit, potato (e.g. anthracnose pathogen: Black spots), anthracnose on beans (such as Colletotrichum gloeosporioides), and soybeans (such as Colletotrichum gloeosporioides or Colletotrichum gloeosporioides) (Anthracnose) (anthracnose) on rice Genera, such as sheath blight (sheath blight); leaf spots on soybeans and ornamental plants; freckles on olive trees; fruit trees, grape vines (eg Liriodendron spp, sexual type, black foot disease) and ornamental plants Cylindrosporium (fruit tree canker disease or young vine decline, heteromorphs: necrosis or primary spores) on soybeans; detoxified plants (amoeba: Rosa) necrotic fungi (root and stem rot) on soybeans; bean rounds on soybeans Phytophthora spp.; corn, grains such as barley (such as cylindrical fungus, net spot disease) and wheat (such as wheat: brown spot), rice and lawn Bipolaris (helminth spores, distant cambium: nuclear pores) Insects); on grapevines caused by ants (shelf fungus), verbena, rehmannia, Phaeodactylum chlamydomonas (premature Phaeodactylum chlamydomonas), Phaeodactylum and/or Bacillus platensis Blight; Pear fruit, soft fruit (anthracnose) and vine (anthracnose) on the cystic cavity disease; rice black swollen disease on rice; wheat black mold; sugar beet (beet black mold), vegetables ( (Such as peas), powdery mildew on gourds (such as chicory), cabbage, rape (such as cruciferous plants); fruit trees, vines, and birch on ornamental forests The top blight (asexual ulcer or tip blight, asexual reproduction: Cytosporium. Meibococcus); parasites on corn (eg turmeric); Fusarium (wilting, root rot or stem rot) on various plants, such as gramineous or hamsters (root rot, scab) on cereals (eg wheat or barley) (Or head disease), oxidospore bacteria on tomatoes, eggplant Fusarium wilt (now Glycine bacteria) on eggplants. Viral types and Tumania and Brazil protozoa cause sudden death syndrome on soybeans and Bacillus rotatum on corn; Bacillus graminearum on cereal crops (such as wheat or barley) and corn; on cereal crops Gibberella spp. (such as corn) and rice (Bakan disease); Chlorella cingulate on grapes, grapefruit and other plants; Helicoverpa armigera on cotton; Gramineae complex on rice; grapes Gignerella (black rot); gymnosporozoites on Rosaceae and juniper, such as Sabina (rust fungus) on pears; Helminthosporium on corn, grains and rice; coffee on coffee Puccinia spp., such as coffee rust (coffee leaf rust); Cladosporium on grapevine; macrophage (root and stem rot) on soybeans and cotton; small grains on cereals (such as wheat or barley) Spore fungus (pink snow mold); Microspore fungus (powdery mildew) on soybeans; Sclerotium on stone fruits and other Rosaceae plants, such as flowering and shoot blight, brown rot; in cereals, bananas Leaf spot disease on soft fruits and crushed nuts, such as wheat cola (morphomorph: Rhizoctonia solani, Needle leaf spot disease) or Fiji mold (smut) on bananas; cabbage ( Downy mildew (downy mildew) on soybeans (such as cabbage), rape (such as parasites), onions (such as phosphorus destruction), tobacco (whitefly) and soybeans (such as Penicillium manchuria); soybean rust on soybeans; grapes ( Phalaenopsis (such as air pipeworm) and soybean (such as Botrytis cinerea); root rot (root rot and stalk rot) on rape and cabbage, snake eye disease (root rot, leaf spot, and damping) on sugar beet ; Phytophthora spp Spots); Phytophthora on various plants (fusarium wilt, roots, leaves, fruits and stem roots), such as peppers and gourds (such as Phytophthora capsici), soybeans (such as Phytophthora gigas, homologs) Phytophthora sojae, Potatoes and tomatoes (such as late blight) and broad-leaved trees (such as Phytophthora quercus: sudden death); Brassica oleracea (bulbar) on cabbage, rape, radish and other plants; plasma parasites, such as Vitreous malaria on grapes Protozoa (Ponospora grape), Plasmodium harveyi on sunflowers; Cross-silk monocysts (powdery mildew) on Rosaceae, hops, pomegranates and soft fruits, such as the white backed planthopper on apples; more Slime molds, such as cereals, such as barley and wheat (polymyxa Downy mildew), such as Bacillus cuneiformis on gourds or Pythium on hops; Pseudomonas trachea on grapes (red fire or rotiferous disease, Proteomorph: Phalaenopsis); Puccinia spp on various plants Genus (rust), such as wheat (brown or leaf rust), stripe rust fungus (strip rust or yellow rust), dwarf rust fungus (dwarf rust), gramineous rust fungus (stem or black rust), or gramineous rust fungus (Brown or leaf rust), such as Puccinia chrysanthemum (orange rust) on wheat, barley or rye, sugarcane and asparagus; Puccinia vulgaris on wheat (Proteomorph: Bipolaris spp.), small Fusarium graminearum (brown spot disease) or Fusarium graminearum (web spot) on barley; rice blast fungus (distal form: rice blast) and rice blast fungus (rice blast) on rice, lawn, rice Magnaporthe grisea (damping) on, corn, wheat, cotton, grapes, sunflowers, soybeans, sugar beets, vegetables and various other plants (such as Phytophthora extreme or insufficiency); Cylindrosporium, such as leaf spots on barley (Physiological leaf spots) and Pseudomonas longifolia on sugar beet; Rhizoctonia spp on cotton, rice, potato, lawn, corn, rape, potato, sugar beet, vegetables and various other plants, such as Rhizoctonia on soybean Rhizoctonia (rhizome rot), Rhizoctonia solani on rice (sheath blight) or wheat sheath blight (sheath blight) on wheat or barley; creeping on black mold, carrots, cabbage, vines and tomatoes Rhizopus (black mold, soft rot); Barley moss (scalded)-like on barley, rye and triticale; Magnaporthe grisea and Streptococcus sparse (sheath rot) on rice; on vegetables and field crops Sclerotinia sclerotiorum (stem rot or white mold), such as rape, sunflower (e.g. Sclerotinia sclerotiorum) and soybean (e.g. Rosella sclerotiorum); the sclerotium on various plants, such as streptococcus glycine (brown spot) on soybeans ), Phytophthora grisea on wheat (Conchosporium sp , Anamorph: Odontosporum); corn (such as turmeric, homologous: Bipolaris phyllocarpa) and leaf blight pathogens on the lawn; corn (such as corn head smut: head smut), sorghum and Smut fungus on sugarcane (smut); globular spore fungus (powder mold) on gourds; sponge spore fungus (powdery scabies) on potatoes, which spread viral diseases; chicosporium on cereals Bacteria, such as Ceratocystis sp ); such as Proteus on peaches (leaf curl disease) and exocystis on plums (plum bag); rhizotrichum (black root rot) on tobacco, grapefruit, vegetables, soybeans and cotton, such as black root rot Diseases (proteomorphs: elegant dark endospores); Tilletia spp. (common fennel or stinky smut) on grains, such as Tilletia vulgaris (alien. Wheat smut) and Wheat dwarf smut (dwarf smut); Sarcosporonium (Grey snow mold) on barley or wheat; smut fungus, such as stalk smut on rye; vegetables, such as Puccinia spp. on beans (Puccinia vulgaris) and sugar beets (rust); smut on cereals (eg, smut), corn (eg, smut: corn smut) and smut on sugar cane Genus; Venturia (scab) on apples (eg, scab) and pears; Verticillium wilt (wilt) on various plants such as fruits, ornamental plants, grapevines, soft fruits, vegetables and field crops Disease), such as Verticillium dahliae on strawberries, rapeseed, potatoes and tomatoes.
本發明還涉及根據本發明的新型農用化學組合物在治療大豆疾病中的用途。The invention also relates to the use of the novel agrochemical composition according to the invention in the treatment of soybean diseases.
最優選的是以下大豆疾病：Most preferred are the following soybean diseases:
大豆紫斑病菌，大豆灰斑病菌；赤葉枯刺盤孢菌、束狀刺盤孢、大豆炭疽病菌；褐斑病菌；大豆莖潰瘍病菌；擴散叉絲殼；東北霜黴；Soybean purpura, Soybean gray spot disease; Colletotrichum arachnoides, Colletotrichum fascicularis, Colletotrichum gloeosporioides, Colletotrichum gloeosporioides, Colletotrichum gloeosporioides, Colletotrichum gloeosporioides, Colletotrichum gloeosporioides, Colletotrichum gloeosporioides;
層鏽菌屬，例如豆薯層鏽菌和山馬蝗層菌(大豆銹病菌)；大雄疫黴；大豆莖褐腐病菌；立枯絲核菌；菌核病菌；殼針孢屬，例如大豆殼針孢，根串珠黴菌。Puccinia spp, such as Puccinia vulgaris and Puccinia serrata (Soybean rust fungus); Phytophthora macrocarpa; Brown rot of soybean stem; Rhizoctonia solani; Sclerotinia sclerotiorum; Needle spores, such as soybean Needle spores, rhizotrichum.
此外，本發明的新型農用化學組合物可降低收穫物及由此製備的食品和飼料中的真菌毒素含量。真菌毒素特別包括但不限於以下幾種：去氧雪腐鐮刀菌烯醇（DON）、雪腐鐮刀菌烯醇、15-Ac-DON、3-Ac-DON、T2-和HT2毒素、伏馬菌素、玉米赤黴烯酮、串珠鐮刀菌素、鐮刀菌素、雙孢黴素、白僵菌素、恩鐮孢菌素、多育麴菌素、赭麯黴毒素、展青黴素、麥角生物鹼和黃麴黴毒素，產生這些毒素的真菌的例子有： 鐮刀菌屬，例如銳頂鐮刀菌、 亞洲鐮孢菌，燕麥鐮孢、克地鐮刀菌、黃色鐮刀菌、禾穀鐮刀菌 (玉米赤黴)、木賊鐮刀菌、尖孢鐮刀菌、層生鐮刀菌、梨孢鐮刀菌、小麥冠腐病菌、接骨木鐮刀菌、草鐮刀菌、半裸鐮刀菌、腐皮鐮孢黴菌、團鐮孢菌、三隔鐮孢、輪狀鐮刀黴菌等；還有麯黴屬、例如黃麴黴、寄生麯黴、赭麯黴、棒麯黴、土麯黴、花斑麯黴；青黴菌屬、例如鮮綠青黴、純綠色肯黴、橘青黴、擴展青黴、棒形青黴、婁地青黴；麥角菌屬、例如黑麥麥角菌、梭形麥角、雀稗麥角菌、非洲麥角菌；葡萄穗黴屬及其他。In addition, the novel agrochemical composition of the present invention can reduce the mycotoxin content in the harvest and the food and feed prepared therefrom. Mycotoxins specifically include but are not limited to the following: deoxynivalenol (DON), nivalenol, 15-Ac-DON, 3-Ac-DON, T2- and HT2 toxins, Fumar Zearalenone, Leuconostoc, Fusarium, Bisporin, Beauverin, Enniacin, Polytoxin, Ochratoxin, Patulin, Ergot Alkali and aflatoxin. Examples of fungi that produce these toxins are: Fusarium, such as Fusarium acuminata, Fusarium asiatica , Fusarium oativa, Fusarium graminicus, Fusarium flavum, Fusarium graminearum (corn Fusarium spp Aspergillus, Fusarium triseptum, Fusarium verticillium, etc.; as well as Aspergillus, such as Aspergillus flavus, Aspergillus parasitica, Aspergillus ochra, Aspergillus clavatus, Aspergillus terreus, Aspergillus variegated; Penicillium, such as Penicillium veratum, Pure Green K. citrinum, Penicillium citrinum, Penicillium dilatum, Penicillium coryneformis, Penicillium lousii; Claviceps spp., such as Ergot ryegrass, Ergot fusiformis, Ergot paspalum, Ergot africanus, Staphylococcus aureus and other.
本發明的新型農用化學化合物還可用於保護材料，尤其是保護工業材料免受植物致病真菌的侵襲和破壞。The new agrochemical compound of the present invention can also be used to protect materials, especially industrial materials from the attack and destruction of phytopathogenic fungi.
本發明的新型農業化學組合物可防止風化、腐爛、變色、脫色或形成黴菌等不良影響。The novel agrochemical composition of the present invention can prevent adverse effects such as weathering, decay, discoloration, decolorization or mold formation.
在處理木材的情況下，本發明的新型農用化學組合物還可用於抵抗易於在木材上或木材內部生長的真菌疾病。In the case of treating wood, the novel agrochemical composition of the present invention can also be used to resist fungal diseases that are easy to grow on or inside wood.
本發明的新型農用化學組合物也可用於保護貯藏物品。貯存物品應被理解為需要長期保護的植物或動物來源的天然物質或其天然來源的加工產品。蔬菜來源的貯存物品，例如植物或植物部分（如莖、葉、塊莖、種子、果實、穀物等），可以通過（預）乾燥、濕潤、粉碎、研磨、壓榨或烘烤等方式保護新鮮收穫或加工後的物品。貯存物品還包括未經加工的木材。The new agrochemical composition of the present invention can also be used to protect storage items. Storage items should be understood as natural materials of plant or animal origin or processed products of natural origin that require long-term protection. Storage items of vegetable origin, such as plants or plant parts (such as stems, leaves, tubers, seeds, fruits, grains, etc.) can be (pre-)dried, moisturized, crushed, ground, pressed or roasted to protect freshly harvested or The processed items. Storage items also include unprocessed wood.
動物來源的儲存物品有獸皮、毛皮和毛髮。本發明的農用化學組合物可防止腐爛、變色、脫色或形成黴菌等不良影響。Storage items of animal origin include animal skins, furs and hair. The agrochemical composition of the present invention can prevent bad effects such as rot, discoloration, decolorization or mold formation.
能夠降解或改變工業材料的微生物包括，例如細菌、真菌、酵母、藻類和黏菌有機體。本發明的農用化學組合物優選地作用於真菌，尤其是黴菌、木材變色和木材腐朽真菌（子囊菌、擔子菌、半知菌綱和接合菌），以及對抗黏菌和藻類。示例包括以下種類的微生物： 鏈格孢屬，如細交鏈孢黴；麯黴屬，如黑麯黴；毛殼菌屬，如球毛殼菌；粉孢革菌屬，如梨孢黴；香菇屬，如變色多孔菌；短梗黴屬，如出芽短梗黴菌；核莖點屬；如球毛殼菌；木黴屬，如綠色木黴；蛇口殼屬，長喙殼屬；腐質黴屬；彼得殼屬；針葉莧屬；革蓋菌屬；褶菌屬；側耳屬；臥孔菌屬；龍介蟲；乾酪菌屬；枝孢屬和擬青黴屬；毛黴屬；埃希氏桿菌屬；如大腸桿菌；假單胞菌屬，如綠膿假單胞菌；假單胞菌屬，如大腸桿菌如銅綠假單胞菌；葡萄球菌，如金黃色葡萄球菌、念珠菌屬和酵母菌屬，如釀酒酵母。Microorganisms capable of degrading or altering industrial materials include, for example, bacteria, fungi, yeasts, algae, and slime mold organisms. The agrochemical composition of the present invention preferably acts on fungi, especially mold, wood discoloration and wood decay fungi (ascomycetes, basidiomycetes, deuteromycetes and zygomycetes), as well as against slime molds and algae. Examples include the following types of microorganisms: Alternaria, such as Alternaria tenuis; Aspergillus, such as Aspergillus niger; Chaetomium, such as Chaetomium globosum; Onoderma, such as Pyricularia; Lentinula , Such as polyporus chromophores; Aureobasidium pullulans, such as Aureobasidium pullulans; Sclerosoma; such as Chaetomium globosum; Trichoderma, such as Trichoderma viride; Shekou shells, Ceratophyllum; Humicola ; Petrella; Amaranthus; Coriolus; Pleurotus; Pleurotus; Lycoporus; Dracunculus; Caseomycetes; Cladosporium and Paecilomyces; Mucor; Escherichia Genus; such as Escherichia coli; Pseudomonas, such as Pseudomonas aeruginosa; Pseudomonas, such as Escherichia coli such as Pseudomonas aeruginosa; Staphylococcus, such as Staphylococcus aureus, Candida and yeast Bacteria, such as Saccharomyces cerevisiae.
本發明的新型農用化學組合物還可以以特定的濃度或施用率用於改善植物特性，或用作殺微生物劑，例如用作殺菌劑，殺病毒劑（包括抗類病毒的組合物）或抗類支原體樣生物（MLO）的組合物和類立克次體（RLO）。The novel agrochemical composition of the present invention can also be used at a specific concentration or application rate to improve plant characteristics, or as a microbicide, for example, as a fungicide, a virucide (including an antiviral composition) or an antimicrobial agent. Compositions of Mycoplasma-like organisms (MLO) and Rickettsia-like organisms (RLO).
本發明的新型農業化學組合物可以介入植物的生理過程，因此也可以用作植物生長調節劑。The novel agrochemical composition of the present invention can intervene in the physiological process of plants, and therefore can also be used as a plant growth regulator.
生長調節作用包括使其更早發芽、更好出芽、根系更發達和/或根系生長得到改善、分蘖能力得到增強，分蘖後具有更高的生產力、更早開花、植物高度和/或生物量增加、莖短、芽生長、籽粒數/穗、穗數/平方米、莖數和/或花朵數得到改善、收穫指數得到增強、葉片更大、基部死葉更少、葉輪系統得到改善、更早成熟/更早落果、均勻成熟、穀物充實時間延長、更好地落果、更大的水果/蔬菜尺寸、抗發芽和減少倒伏。Growth regulation effects include earlier germination, better germination, more developed roots and/or improved root growth, enhanced tillering ability, higher productivity after tillering, earlier flowering, increased plant height and/or biomass , Short stems, bud growth, number of grains/ears, number of ears/square meter, number of stems and/or flowers improved, harvest index improved, leaves larger, fewer dead leaves at the base, improved impeller system, earlier Ripe/earlier fruit drop, uniform ripeness, longer grain filling time, better fruit drop, larger fruit/vegetable size, resistance to germination and reduced lodging.
產量增加或提高是指每公頃總生物量、每公頃產量、果仁/果實重量、種子大小和/或百公升重量以及產品品質的提高，包括：改善了與粒徑分佈（果仁、水果等）有關的加工性能、均勻成熟、穀物水分、碾磨性、釀造性、果汁產量、可收穫性、消化率、沉降值、下降數、莢果穩定性、儲存穩定性、改善纖維長度/強度/均勻性、牛奶量和/或滿足青貯飼料餵養動物的品質，適應烹飪和油炸；還包括與改善的水果/穀物品質、粒徑分佈（內核、水果等）、增加的存儲/保質期、硬度/柔軟度、口味（香氣、質地等）、等級（尺寸、形狀、漿果的數量等）、每束漿果/水果的數量、酥脆度、新鮮度、被蠟覆蓋的程度、生理失常的頻率、顏色等；還包含增加的有益成分，例如蛋白質含量、脂肪酸、油含量、油品質、氨基酸成分、糖含量、酸含量（pH）、糖/酸比（白利糖度）、多酚、澱粉含量、營養品質、麵筋含量/指數、能含量、味道等等。Yield increase or increase refers to the increase in total biomass per hectare, yield per hectare, kernel/fruit weight, seed size and/or hectoliter weight, and product quality, including: improved and particle size distribution (nuts, fruits, etc.) ) Related processing performance, uniform maturity, grain moisture, millability, brewing property, juice yield, harvestability, digestibility, sedimentation value, number of drops, pod stability, storage stability, improved fiber length/strength/uniformity Performance, milk quantity and/or meet the quality of silage feeding animals, suitable for cooking and frying; also include improved fruit/grain quality, particle size distribution (kernel, fruit, etc.), increased storage/shelf life, firmness/softness Degree, taste (aroma, texture, etc.), grade (size, shape, number of berries, etc.), number of berries/fruits per bunch, crispness, freshness, degree of wax coverage, frequency of physiological disorders, color, etc.; It also contains added beneficial ingredients, such as protein content, fatty acid, oil content, oil quality, amino acid content, sugar content, acid content (pH), sugar/acid ratio (brix), polyphenols, starch content, nutritional quality, Gluten content/index, energy content, taste, etc.
本發明的新型農用化學組合物還在植物中表現出強效的增強作用。因此，它們可用於調動植物的防禦能力以抵抗有害微生物的侵襲。The novel agrochemical composition of the present invention also exhibits a potent enhancing effect in plants. Therefore, they can be used to mobilize the defense capabilities of plants to resist the invasion of harmful microorganisms.
在本文中，植物增強（抗性誘導）物質是能夠刺激植物防禦系統的物質。這樣，當隨後將處理過的植物接種不希望的微生物時，它們對這些微生物產生高度的抗性。In this article, plant enhancing (resistance-inducing) substances are substances that can stimulate plant defense systems. In this way, when the treated plants are subsequently inoculated with undesirable microorganisms, they develop a high degree of resistance to these microorganisms.
此外，在本發明的背景下，植物生理作用表現在以下方面：In addition, in the context of the present invention, the physiological effects of plants are manifested in the following aspects:
非生物脅迫耐受性，包括對高溫或低溫的耐受性、乾旱脅迫後的耐旱性和恢復性、水分利用效率（與耗水量減少相關）、耐水性、臭氧脅迫和紫外線耐受性、對重金屬、鹽類、農藥等化學品的耐受性。Abiotic stress tolerance, including tolerance to high or low temperature, drought tolerance and recovery after drought stress, water use efficiency (related to water consumption reduction), water tolerance, ozone stress and UV tolerance, Tolerance to heavy metals, salts, pesticides and other chemicals.
生物脅迫耐受性包括提高真菌抗性和增強對線蟲、病毒和細菌的抗性。在本發明的背景下，生物脅迫耐受優選包括提高真菌抗性和線蟲抗性。Biological stress tolerance includes increased fungal resistance and increased resistance to nematodes, viruses and bacteria. In the context of the present invention, biotic stress tolerance preferably includes improving fungal resistance and nematode resistance.
提高植物活力，包括植物健康/植物品質和種子活力、減少林分衰竭、改善外觀、增加脅迫後的恢復、改善色素沉積（如葉綠素含量、保綠效果等）以及提高光合效率。本發明還包括一種種子處理方法。本發明還提供了用上述方法之一處理過的種子。本發明的種子用於保護種子免受有害微生物的侵害。這些方法使用的是用至少一種本發明的農用化學組合物處理的種子。Improve plant vitality, including plant health/plant quality and seed vitality, reduce stand failure, improve appearance, increase recovery after stress, improve pigmentation (such as chlorophyll content, green preservation effect, etc.) and increase photosynthetic efficiency. The invention also includes a seed treatment method. The present invention also provides seeds treated with one of the above methods. The seeds of the present invention are used to protect the seeds from harmful microorganisms. These methods use seeds treated with at least one agrochemical composition of the present invention.
本發明的新型農業化學組合物也適合於處理種子。有害生物對作物植物造成的大部分損害是由種子在儲存期間或播種後以及植物發芽期間和之後的感染引起的。該階段特別重要，因為生長中的植物的根和芽特別敏感，即使是很小的破壞也可能導致植物死亡。因此，通過使用適當的組合物來保護種子和發芽植物非常有益。The novel agrochemical composition of the present invention is also suitable for treating seeds. Most of the damage caused by pests to crop plants is caused by infection of seeds during storage or after sowing, and during and after germination of plants. This stage is particularly important because the roots and shoots of growing plants are particularly sensitive, and even minor damage can lead to plant death. Therefore, it is very beneficial to protect seeds and germinating plants by using appropriate compositions.
通過處理植物種子控制植物病原真菌的研究由來已久，是一個不斷完善的課題。然而，種子的處理方面還有一系列問題亟待解決。例如，人們希望開發出用於保護種子和發芽植物的方法，這種方法在植物種植後或發芽後免除或至少顯著減少額外的作物保護成分的使用。還希望優化活性成分的用量，以便為種子和發芽植物提供最好的保護，使其免受植物病原性真菌的侵襲，但又不因所用活性成分而損害植物本身。特別地，用於處理種子的方法還應當考慮轉基因植物的內在殺真菌特性，以便以最低成本的作物保護組合物實現對種子和發芽植物的最佳保護。The control of plant pathogenic fungi by treating plant seeds has a long history and is a subject that is constantly improving. However, there are still a series of problems in the treatment of seeds that need to be solved urgently. For example, it is desirable to develop methods for protecting seeds and germinating plants that eliminate or at least significantly reduce the use of additional crop protection ingredients after the plants are planted or germinated. It is also desired to optimize the amount of active ingredients in order to provide the best protection for seeds and germinating plants from the attack of phytopathogenic fungi, but without damaging the plants themselves due to the active ingredients used. In particular, the method for treating seeds should also consider the inherent fungicidal properties of transgenic plants, so as to achieve the best protection of seeds and germinating plants with the lowest cost crop protection composition.
在一個實施方案中，本發明提供了包含殺真菌組合物的種子。In one embodiment, the present invention provides seeds comprising the fungicidal composition.
因此，本發明還涉及通過用本發明的組合物處理種子來保護種子和發芽植物免受植物致病性真菌侵襲的方法。本發明同樣涉及本發明組合物用於處理種子以保護種子和發芽植物免受植物致病真菌侵害的用途。本發明進一步涉及已經用本發明的組合物處理過的種子，以保護其免受植物致病性真菌的侵害。Therefore, the present invention also relates to a method for protecting seeds and germinating plants from attack by phytopathogenic fungi by treating the seeds with the composition of the present invention. The invention also relates to the use of the composition of the invention for treating seeds to protect the seeds and germinating plants from phytopathogenic fungi. The invention further relates to seeds that have been treated with the composition of the invention to protect them from phytopathogenic fungi.
主要通過用農作物保護組合物處理土壤和植物的地上部分來影響對發芽後植物的植物致病真菌的控制。由於擔心農作物保護組合物可能對環境以及人類和動物健康造成影響，人們正在努力減少所使用的活性成分的量。The control of phytopathogenic fungi of plants after germination is mainly affected by treating the soil and the above-ground parts of plants with crop protection compositions. Due to concerns that crop protection compositions may have an impact on the environment and human and animal health, efforts are being made to reduce the amount of active ingredients used.
本發明的優點之一是，新型農業化學組合物的特殊系統特性不僅保護種子本身，而且保護出苗後產生的植物免受植物病原真菌的侵害。這樣，就可以免除在播種時或播種後不久立即對作物進行處理。One of the advantages of the present invention is that the special system characteristics of the new agrochemical composition not only protect the seeds themselves, but also protect the plants produced after emergence from phytopathogenic fungi. In this way, it is possible to dispense with processing crops at or shortly after planting.
同樣認為有利的是，新型的農業化學組合物也可以特別用於轉基因種子，在這種情況下，從該種子生長的植物能夠表達一種對抗害蟲的蛋白質。利用新的農業化學組合物處理這種種子，僅僅通過表達殺蟲蛋白就能控制某些害蟲。令人驚訝的是，在這種情況下，可以觀察到進一步的協同效應，從而增加了抵禦害蟲攻擊的有效性。It is also considered advantageous that the novel agrochemical composition can also be used in particular for transgenic seeds, in which case the plants grown from the seeds can express a pest-resistant protein. Using new agrochemical compositions to treat such seeds can control certain pests simply by expressing insecticidal proteins. Surprisingly, in this case, a further synergistic effect can be observed, thereby increasing the effectiveness of resisting pest attacks.
本發明的新型農業化學組合物適用於保護農業、溫室、森林或園藝和葡萄栽培的任何植物品種的種子。特別是穀類（如小麥、大麥、黑麥、小黑麥、高粱/小米和燕麥）、玉米、棉花、大豆、大米、土豆、向日葵、大豆、咖啡、甜菜（例如甜菜和飼料甜菜）、花生、油菜、罌粟、橄欖、椰子、可哥、甘蔗、煙草、蔬菜（如番茄、黃瓜、洋蔥和生菜）、草皮和觀賞植物（見下文）。穀物（如小麥、大麥、黑麥、小黑麥和燕麥）、玉米和水稻的種子處理具有特別重要的意義。The novel agrochemical composition of the present invention is suitable for protecting the seeds of any plant variety in agriculture, greenhouse, forest or horticulture and viticulture. Especially cereals (such as wheat, barley, rye, triticale, sorghum/millet and oats), corn, cotton, soybeans, rice, potatoes, sunflowers, soybeans, coffee, sugar beets (such as sugar beets and fodder beets), peanuts, Canola, poppy, olive, coconut, cocoa, sugar cane, tobacco, vegetables (such as tomato, cucumber, onion and lettuce), turf and ornamental plants (see below). Seed treatment of cereals (such as wheat, barley, rye, triticale and oats), corn and rice is of particular importance.
如本文所述，用新型農業化學組合物處理轉基因種子也具有特別的意義。這涉及包含至少一個異源基因的植物種子，所述異源基因能夠表達具有殺蟲特性的多肽或蛋白質。轉基因種子中的異源基因可以源自下列微生物：芽孢桿菌屬、根瘤菌屬、假單胞菌屬、沙雷氏菌屬、木黴屬、棒狀桿菌屬、球囊黴屬或黏帚黴屬。該異源基因優選源自芽孢桿菌屬，在這種情況下，該基因產物對歐洲玉米螟和/或西方玉米根蟲有效。異源基因更優選源自蘇雲金芽孢桿菌。As described herein, the treatment of transgenic seeds with new agrochemical compositions is also of special significance. This involves plant seeds containing at least one heterologous gene capable of expressing a polypeptide or protein with insecticidal properties. The heterologous genes in the transgenic seeds can be derived from the following microorganisms: Bacillus, Rhizobium, Pseudomonas, Serratia, Trichoderma, Corynebacterium, Globulin, or Gliocladium Genus. The heterologous gene is preferably derived from the genus Bacillus, in which case the gene product is effective against European corn borer and/or western corn rootworm. The heterologous gene is more preferably derived from Bacillus thuringiensis.
在本發明的背景下，新的農用化學組合物單獨或以合適的配方施用於種子。優選地，在處理種子過程中，要保證狀態穩定，不發生損害。通常，種子可以在收穫到播種後的任何時間進行處理。通常使用從植物中分離出來的，沒有穗子、殼、莖、皮、毛或果肉的種子。例如，可以使用已經收穫、清潔和乾燥至水分含量占重量小於15％的種子。或者，也可以使用乾燥後（例如經過水處理後又乾燥）的種子。In the context of the present invention, the new agrochemical composition is applied to the seed alone or in a suitable formulation. Preferably, in the process of treating the seeds, it is necessary to ensure that the state is stable and no damage occurs. Generally, seeds can be processed at any time after harvest to sowing. Usually used are seeds that are separated from plants and do not have ears, shells, stems, skins, hairs or pulp. For example, it is possible to use seeds that have been harvested, cleaned and dried to a moisture content of less than 15% by weight. Alternatively, seeds that have been dried (for example, dried after water treatment) can also be used.
當處理種子時，通常必須確保選擇合適的新型農用化學組合物的量和 /或另外的添加劑的量來施用於種子，以使種子的發芽不受到損害，或長出的植物不受損害。這一點必須牢記，特別是對於活性成分，它們在一定的施用量下可能具有植物毒性作用。When treating seeds, it is generally necessary to ensure that the appropriate amount of the new agrochemical composition and/or the amount of additional additives are selected to be applied to the seeds so that the germination of the seeds is not damaged, or the growing plants are not damaged. This must be kept in mind, especially for active ingredients, which may have phytotoxic effects at a certain application rate.
本發明進一步涉及用於控制有害微生物的新型農用化學組合物。所述農用化學組合物可以施用於微生物和/或它們的棲息地。The present invention further relates to a new agrochemical composition for controlling harmful microorganisms. The agrochemical composition can be applied to microorganisms and/or their habitat.
農用化學組合物通常包括至少一種活性化合物組合和至少一種農業上適宜的助劑，例如載體和/或表面活性劑。Agrochemical compositions generally include at least one combination of active compounds and at least one agriculturally suitable adjuvant, such as a carrier and/or surfactant.
在本發明的背景下，“有害微生物的控制”是指與未經處理的植物相比，有害微生物的侵染減少，作為殺菌效果的測量，與未經處理的植物相比（100%），優選減少25-50%，更優選減少40-79%；更理想的是，完全抑制有害微生物的感染（70-100%）。控制可以是治療性的（即治療已經感染的植物），也可以是保護性的（即保護尚未感染的植物）。In the context of the present invention, "control of harmful microorganisms" means that the infestation of harmful microorganisms is reduced compared with untreated plants. As a measure of the bactericidal effect, compared with untreated plants (100%), Preferably, it is reduced by 25-50%, more preferably by 40-79%; more ideally, the infection of harmful microorganisms is completely inhibited (70-100%). Control can be curative (that is, treating plants that have been infected) or protective (that is, protecting plants that have not yet been infected).
“有效但不會造成植物毒性的量”，是指新型農業化學組合物的量足以以令人滿意的方式控制植物的真菌病或完全根除真菌病，同時不會引起任何明顯的植物毒性症狀。通常，該施用率可以在相對寬的範圍內變化。它取決於幾個因素，例如取決於要控制的真菌、植物、氣候條件和本發明組合物的成分。"Amount that is effective but does not cause phytotoxicity" refers to the amount of the new agricultural chemical composition that is sufficient to control or completely eradicate fungal diseases of plants in a satisfactory manner without causing any obvious symptoms of phytotoxicity. Generally, the application rate can be varied within a relatively wide range. It depends on several factors, such as the fungi to be controlled, plants, climatic conditions and the composition of the composition of the invention.
載體是一種固體或液體，天然或合成，有機或無機物質，通常是惰性的。載體通常改善化合物的應用，例如，用於植物、植物部分或種子。合適的固體載體的實例包括但不限於銨鹽、天然岩石粉（例如高嶺土、黏土、滑石粉、白堊、石英、凹凸棒石、蒙脫石和矽藻土）以及合成岩石粉，例如矽粉、氧化鋁和矽酸鹽。用於製備顆粒的典型有用固體載體的實例包括但不限於粉碎和分餾的天然岩石（例如方解石、大理石、浮石、海泡石和白雲石）、無機和有機麵粉的合成顆粒以及有機材料（例如紙、鋸末、椰子殼、玉米棒和煙草秸稈）的顆粒。合適的液體載體的實例包括但不限於水、有機溶劑及其組合。合適的溶劑的實例包括極性及非極性有機化學液體，例如來自芳香族及非芳香族碳氫化合物（例如環己烷、鏈烷烴、烷基苯、二甲苯、甲苯烷基萘、氯化芳烴或氯化脂肪族烴，例如氯苯、氯乙烯或亞甲基氯）、醇和多元醇（也可任選地被取代、醚化和/或酯化，例如丁醇或乙二醇）、酮（例如丙酮、甲乙酮、甲基異丁基酮或環己酮）、酯類（包括脂肪和油）和（聚）醚、未被取代和被取代的胺、醯胺（例如二甲基甲醯胺），內醯胺（如N-烷基吡咯烷酮）和內酯、碸和亞碸（如二甲基亞碸）。載體也可以是液化氣體增量劑，即在標準溫度和標準壓力下為氣態的液體，例如鹵代烴、丁烷、丙烷、氮氣和二氧化碳等氣溶膠推進劑。The carrier is a solid or liquid, natural or synthetic, organic or inorganic substance, usually inert. The carrier generally improves the application of the compound, for example, to plants, plant parts or seeds. Examples of suitable solid carriers include, but are not limited to, ammonium salts, natural rock powders (such as kaolin, clay, talc, chalk, quartz, attapulgite, montmorillonite, and diatomaceous earth), and synthetic rock powders, such as silica powder, oxidized Aluminum and silicate. Examples of typical useful solid carriers for preparing particles include, but are not limited to, crushed and fractionated natural rocks (such as calcite, marble, pumice, sepiolite, and dolomite), synthetic particles of inorganic and organic flour, and organic materials (such as paper, Sawdust, coconut husk, corn on the cob and tobacco straw). Examples of suitable liquid carriers include, but are not limited to, water, organic solvents, and combinations thereof. Examples of suitable solvents include polar and non-polar organic chemical liquids, such as from aromatic and non-aromatic hydrocarbons (such as cyclohexane, paraffins, alkylbenzenes, xylenes, toluene alkyl naphthalenes, chlorinated aromatic hydrocarbons or Chlorinated aliphatic hydrocarbons, such as chlorobenzene, vinyl chloride or methylene chloride), alcohols and polyols (also optionally substituted, etherified and/or esterified, such as butanol or ethylene glycol), ketones ( Such as acetone, methyl ethyl ketone, methyl isobutyl ketone or cyclohexanone), esters (including fats and oils) and (poly) ethers, unsubstituted and substituted amines, amides (such as dimethylformamide) ), lactones (such as N-alkylpyrrolidone) and lactones, sulfite and sulfite (such as dimethyl sulfite). The carrier can also be a liquefied gas extender, that is, a gaseous liquid at standard temperature and standard pressure, such as aerosol propellants such as halogenated hydrocarbons, butane, propane, nitrogen, and carbon dioxide.
所述表面活性劑可以是離子（陽離子或陰離子）或非離子表面活性劑，例如離子或非離子乳化劑、泡沫形成劑、分散劑、潤濕劑及其任何混合物。合適的表面活性劑的實例包括但不限於聚丙烯酸鹽、木質素磺酸鹽、酚磺酸或萘磺酸鹽、乙烯和/或環氧丙烷與脂肪醇、脂肪酸或脂肪胺的縮聚物醚（聚氧乙烯脂肪酸酯、聚氧乙烯脂肪醇，例如烷基醯聚乙二醇醚）、取代酚（優選烷基酚或芳基酚）、磺基琥珀酸酯鹽、牛磺酸衍生物（優選烷基牛磺酸酯）、聚乙氧基化醇或酚的磷酸酯、多元醇脂肪酸酯和含有硫酸鹽、磺酸鹽、磷酸鹽的化合物的衍生物（例如烷基磺酸鹽、烷基硫酸鹽、芳基磺酸鹽）和蛋白質水解物、木質素磺酸鹽廢液和甲基纖維素。表面活性劑通常在式（I）和/或載體的組合物不溶於水但施用時要用到水時使用。然後，表面活性劑的量通常在組合物重量的5%到40%之間。The surfactant may be an ionic (cationic or anionic) or non-ionic surfactant, such as an ionic or non-ionic emulsifier, a foam former, a dispersant, a wetting agent, and any mixtures thereof. Examples of suitable surfactants include, but are not limited to, polyacrylate, lignosulfonate, phenolsulfonic acid or naphthalenesulfonate, polycondensate ethers of ethylene and/or propylene oxide with fatty alcohols, fatty acids or fatty amines ( Polyoxyethylene fatty acid esters, polyoxyethylene fatty alcohols, such as alkyl polyglycol ethers), substituted phenols (preferably alkyl phenols or aryl phenols), sulfosuccinate salts, taurine derivatives ( Preferred alkyl taurates), polyethoxylated alcohol or phenol phosphate esters, polyol fatty acid esters, and derivatives of compounds containing sulfates, sulfonates and phosphates (such as alkyl sulfonates, Alkyl sulfate, aryl sulfonate) and protein hydrolysate, lignosulfonate waste liquid and methyl cellulose. Surfactants are usually used when the composition of formula (I) and/or carrier is insoluble in water but water is needed for application. Then, the amount of surfactant is usually between 5% and 40% by weight of the composition.
此外，合適的助劑實例包括防水劑、乾燥劑、黏合劑（黏合劑、增黏劑、羧甲基纖維素等固定劑）、粉末、顆粒或膠乳形式的天然及合成聚合物，例如阿拉伯膠、聚乙烯醇及聚醋酸乙烯酯、天然磷脂（例如頭孢烷及卵磷脂）及合成磷脂、聚乙烯吡咯烷酮、聚醋酸乙烯酯、聚乙烯醇和侵填體）、增稠劑、穩定劑（例如冷穩定劑、防腐劑、抗氧化劑、光穩定劑或其他提高化學和/或物理穩定性的試劑）、染料或顏料（例如無機顏料，例如氧化鐵、氧化鈦和普魯士藍；有機染料，如茜草色素、偶氮和金屬酞菁染料）、消泡劑（例如有機矽消泡劑和硬脂酸鎂）、防腐劑（例如二氯苯酚和苄醇半甲醛）、二次增稠劑（纖維素衍生物、丙烯酸衍生物、黃原膠、改性黏土和矽粉）、黏著劑、赤黴素和加工助劑、礦物油和植物油、香水、蠟、營養素（包括微量營養素，如鐵、錳、硼、銅、鈷、鉬和鋅鹽）、保護膠體、觸變物質、滲透劑、螯合劑和配位劑；In addition, examples of suitable additives include waterproofing agents, desiccants, adhesives (adhesives, tackifiers, fixatives such as carboxymethyl cellulose), natural and synthetic polymers in the form of powder, granules or latex, such as gum arabic , Polyvinyl alcohol and polyvinyl acetate, natural phospholipids (such as cephalan and lecithin) and synthetic phospholipids, polyvinylpyrrolidone, polyvinyl acetate, polyvinyl alcohol and fillers), thickeners, stabilizers (such as cold Stabilizers, preservatives, antioxidants, light stabilizers or other agents that improve chemical and/or physical stability), dyes or pigments (such as inorganic pigments, such as iron oxide, titanium oxide, and Prussian blue; organic dyes, such as madder pigment) , Azo and metal phthalocyanine dyes), defoamers (such as silicone defoamers and magnesium stearate), preservatives (such as dichlorophenol and benzyl alcohol semiformaldehyde), secondary thickeners (cellulose derived Compounds, acrylic acid derivatives, xanthan gum, modified clay and silica powder), adhesives, gibberellins and processing aids, mineral and vegetable oils, perfumes, waxes, nutrients (including micronutrients such as iron, manganese, boron , Copper, cobalt, molybdenum and zinc salts), protective colloids, thixotropic substances, penetrants, chelating agents and complexing agents;
助劑的選擇與式（I）化合物的預期應用方式和/或物理性能有關。此外，可以選擇助劑以賦予組合物特定的性質（技術，物理和/或生物學性質）或使用由此製備的形式。可以根據具體需要選擇助劑來定制組合物。The choice of adjuvant is related to the expected application mode and/or physical properties of the compound of formula (I). In addition, adjuvants can be selected to impart specific properties (technical, physical and/or biological properties) to the composition or used in a form prepared therefrom. The adjuvant can be selected according to specific needs to customize the composition.
本發明的新型農業化學組合物可為任何慣用形式，例如溶液（例如水溶液）、乳液、可濕性粉末、水性和油性懸浮液、粉末、粉塵、糊狀物、可溶性粉末、可溶性顆粒、播撒用顆粒物、懸浮乳液濃縮物、浸有農用化學成分天然或合成產品、肥料以及聚合物質中的微膠囊。本發明的農業化學組合物可以懸浮、乳化或溶解形式存在。The novel agrochemical composition of the present invention can be in any conventional form, such as solutions (such as aqueous solutions), emulsions, wettable powders, aqueous and oily suspensions, powders, dusts, pastes, soluble powders, soluble particles, for broadcasting Particles, suspension emulsion concentrates, natural or synthetic products impregnated with agricultural chemicals, fertilizers, and microcapsules in polymer materials. The agrochemical composition of the present invention can exist in suspended, emulsified or dissolved form.
提供給最終用戶的本發明的新型農用化學組合物可以是即用製劑，即可以通過合適的裝置（例如噴霧或除塵裝置）將所述組合物直接施用到植物或種子上。或者濃縮物的形式，即使用前必須被稀釋（優選用水稀釋）。The novel agrochemical composition of the present invention provided to the end user can be a ready-to-use preparation, that is, the composition can be directly applied to plants or seeds through a suitable device (such as a spray or dust removal device). Or in the form of a concentrate, that must be diluted before use (preferably diluted with water).
本發明的新型農用化學組合物可以常規方式製備，例如通過將本發明的農用化學組合物與一種或多種合適的助劑（例如上文中公開的助劑）混合。The novel agrochemical composition of the present invention can be prepared in a conventional manner, for example, by mixing the agrochemical composition of the present invention with one or more suitable adjuvants (for example, the adjuvants disclosed above).
本發明的新型農用化學組合物通常包含占總重量0.01至99％，0.05至98％，優選0.1至95％，更優選0.5至90％，最優選10至70％的本發明的活性化合物。The new agrochemical composition of the present invention usually contains 0.01 to 99%, 0.05 to 98%, preferably 0.1 to 95%, more preferably 0.5 to 90%, and most preferably 10 to 70% of the active compound of the present invention, based on the total weight.
施用量在很寬的範圍內變化，具體取決於土壤的性質、施用方法、農作物、要防治的害蟲、主要氣候條件、其他受施用方法支配的因素、施用時間以及目標作物等因素的影響。一般而言，化合物的施用量可以為1至2000 L/公頃，特別是10至1000 L/公頃。The amount of application varies within a wide range, depending on the nature of the soil, application methods, crops, pests to be controlled, main climatic conditions, other factors governed by the application method, application time, and target crops. In general, the application rate of the compound can be 1 to 2000 L/ha, especially 10 to 1000 L/ha.
該新型農用化學組合物可以直接施用（即不加任何其他成分、不稀釋）。通常，優選以合適的製劑形式將組合物施用於種子。用於種子處理的合適製劑和方法是本領域技術人員已知的，在以下檔中有描述：US 4,272,417、US 4,245,432、US 4,808,430、US 5,876,739、US 2003/0176428 Al、WO 2002/080675、WO 2002/028186。The new agrochemical composition can be applied directly (that is, without adding any other ingredients, without dilution). Generally, it is preferred to apply the composition to the seed in the form of a suitable formulation. Suitable formulations and methods for seed treatment are known to those skilled in the art and are described in the following files: US 4,272,417, US 4,245,432, US 4,808,430, US 5,876,739, US 2003/0176428 Al, WO 2002/080675, WO 2002 /028186.
本發明使用的新型農用化學組合物可以轉化為常規的拌種製劑，例如溶液、乳液、懸浮液、粉末、泡沫、漿液或其他種子包衣組合物，以及超低容量溶液。The new agrochemical composition used in the present invention can be converted into conventional seed dressing formulations, such as solutions, emulsions, suspensions, powders, foams, slurries or other seed coating compositions, as well as ultra-low volume solutions.
這些製劑可以已知的方式製備——通過將活性化合物與常規的添加劑，例如常規的增量劑以及溶劑或稀釋劑、染料、潤濕劑、分散劑、乳化劑、消泡劑、防腐劑、二次增稠劑、黏合劑、赤黴素和還有水混合。These preparations can be prepared in a known manner-by combining the active compound with conventional additives, such as conventional extenders and solvents or diluents, dyes, wetting agents, dispersants, emulsifiers, defoamers, preservatives, The secondary thickener, binder, gibberellin and water are mixed.
可以在本發明的拌種劑中使用的有用的染料是所有常規用於此類目的的染料。可以使用微溶於水的顏料或水溶性的染料。實例包括名稱為若丹明B，C.I.顏料紅112和C.I.溶劑紅1.的染料。可用於本發明的拌種劑中的有用的潤濕劑是所有促進潤濕並且其通常用於配製活性農業化學成分的物質。優選使用烷基萘磺酸烷基酯，例如二異丙基萘磺酸鈉或二異丁基萘磺酸酯。Useful dyes that can be used in the seed dressing of the present invention are all dyes conventionally used for such purposes. It is possible to use slightly water-soluble pigments or water-soluble dyes. Examples include dyes named Rhodamine B, C.I. Pigment Red 112 and C.I. Solvent Red 1. Useful wetting agents that can be used in the seed dressing of the present invention are all substances that promote wetting and which are commonly used to formulate active agrochemical ingredients. Preference is given to using alkyl naphthalene sulfonate alkyl esters, such as sodium diisopropyl naphthalene sulfonate or diisobutyl naphthalene sulfonate.
可以在本發明的拌種劑中使用的有用的分散劑和/或乳化劑是常規用於活性農業化學成分配製的所有非離子、陰離子和陽離子分散劑。優選使用非離子或陰離子分散劑或非離子或陰離子分散劑的混合物。合適的非離子分散劑尤其包括環氧乙烷/環氧丙烷嵌段聚合物，烷基酚聚乙二醇醚和三苯乙烯基酚聚乙二醇醚，及其磷酸化或硫酸化的衍生物。合適的陰離子分散劑尤其是木質素磺酸鹽，聚丙烯酸鹽和芳基磺酸鹽/甲醛縮合物。Useful dispersants and/or emulsifiers that can be used in the seed dressing of the present invention are all nonionic, anionic and cationic dispersants conventionally used in the formulation of active agrochemical ingredients. Preference is given to using nonionic or anionic dispersants or mixtures of nonionic or anionic dispersants. Suitable nonionic dispersants include in particular ethylene oxide/propylene oxide block polymers, alkylphenol polyethylene glycol ethers and tristyrylphenol polyethylene glycol ethers, and their phosphorylated or sulfated derivatives. Things. Suitable anionic dispersants are especially lignosulfonates, polyacrylates and arylsulfonate/formaldehyde condensates.
可以存在於本發明使用的拌種劑中的消泡劑是常規用於活性農業化學成分配製的所有抑泡物質。可以優先使用有機矽消泡劑和硬脂酸鎂。The defoamers that can be present in the seed dressing used in the present invention are all foam inhibitors conventionally used in the formulation of active agricultural chemical ingredients. Silicone defoamers and magnesium stearate can be used preferentially.
可以在根據本發明使用的拌種製劑中使用的防腐劑是在農業化學組合物中可用於此類目的的所有物質。實例包括二氯苯和苄醇半縮甲醛。The preservatives that can be used in the seed dressing formulations used according to the invention are all substances that can be used for such purposes in agrochemical compositions. Examples include dichlorobenzene and benzyl alcohol hemiformal.
可以在根據本發明的拌種劑中使用的次要增稠劑是在農業化學組合物中可用於此類目的的所有物質。優選的實例包括纖維素衍生物、丙烯酸衍生物、黃原膠、改性黏土和矽粉。Secondary thickeners that can be used in the seed dressing according to the invention are all substances that can be used for such purposes in agrochemical compositions. Preferred examples include cellulose derivatives, acrylic acid derivatives, xanthan gum, modified clay, and silica powder.
可以存在於根據本發明的拌種劑中的黏合劑是可以用於拌種產品的所有常規黏合劑。優選的例子包括聚乙烯吡咯烷酮、聚乙酸乙烯酯、聚乙烯醇和叔糖。The binders that can be present in the seed dressing according to the invention are all conventional binders that can be used in seed dressing products. Preferred examples include polyvinylpyrrolidone, polyvinyl acetate, polyvinyl alcohol and tertiary sugars.
可以在本發明使用的拌種劑中使用的赤黴素可以優選為赤黴素A1、A3（＝赤黴酸）、A4和A7；特別優選使用赤黴酸。Gibberellins that can be used in the seed dressing agent used in the present invention may preferably be gibberellins A1, A3 (=gibberellic acid), A4, and A7; gibberellic acid is particularly preferably used.
可根據本發明使用的拌種製劑可以直接使用或預先用水稀釋後用於處理各種不同的種子，包括轉基因植物的種子。在這種情況下，在與通過表達形成的物質相互作用中也可能發生其他協同效應。The seed dressing formulation that can be used according to the present invention can be used directly or diluted with water in advance to treat various seeds, including seeds of transgenic plants. In this case, other synergistic effects may also occur in the interaction with the substance formed by expression.
為了用根據本發明可用的拌種製劑或由其通過加水製備的製劑處理種子，通常可用拌種的所有混合裝置。具體地，拌種的過程是將種子放入混合器中，直接或在事先用水稀釋後添加特定所需量的拌種製劑，並混合所有物質，直到製劑均勻地分佈在種子上。如果合適，隨後進行乾燥過程。In order to treat seeds with the seed dressing formulations usable according to the invention or the formulations prepared therefrom by adding water, all mixing devices for seed dressing can generally be used. Specifically, the process of seed dressing is to put the seed in a mixer, add a specific required amount of seed dressing formulation directly or after diluting with water in advance, and mix all the materials until the formulation is evenly distributed on the seed. If appropriate, a drying process is followed.
在根據本發明的新型農用化學組合物中，成分（1）和成分（2）有利地、能發生協同作用的有效重量比在100∶1至1∶100的範圍內，優選在50∶1至1∶50的範圍內，更優選在20∶1至1∶20的範圍內，還更優選在10∶1至1∶10的範圍內。In the new agrochemical composition according to the present invention, the effective weight ratio of the component (1) and the component (2) which can produce a synergistic effect is in the range of 100:1 to 1:100, preferably in the range of 50:1 to In the range of 1:50, more preferably in the range of 20:1 to 1:20, still more preferably in the range of 10:1 to 1:10.
成分（1）：成分（2）的重量比在10∶1至1∶10的範圍內內，優選在5∶1至1∶5、4∶1至1∶4、3∶1至1：3、2：1至1：2和1：1的範圍內。The weight ratio of ingredient (1): ingredient (2) is in the range of 10:1 to 1:10, preferably 5:1 to 1:5, 4:1 to 1:4, 3:1 to 1:3 , 2:1 to 1:2 and 1:1.
特別地，該新型農業化學組合物用於葉面施用。In particular, the new agrochemical composition is used for foliar application.
根據本發明，術語“組合物”代表成分（1）和（2）的各種混合物或組合，例如以單一“預拌”形式、由單一活性化合物的單獨配方（例如“罐式”）組成的組合噴霧混合物，以及單一活性成分的組合使用按順序施用（即在相當短的時間內（如幾個小時或幾天）一個接一個地施用）時。優選情況下成分（1）和（2）的施用順序對於本發明不是很重要。According to the present invention, the term "composition" refers to various mixtures or combinations of ingredients (1) and (2), for example, in the form of a single "premix", a combination consisting of a single formulation of a single active compound (for example, a "tank") Spray mixtures, and the combined use of single active ingredients are applied sequentially (ie, one after the other in a relatively short period of time (such as several hours or days)). Preferably, the order of application of components (1) and (2) is not very important to the present invention.
在本發明中，術語“農用化學組合物”是指至少兩種活性化合物與其他農業上合適的添加劑（如上文所述的溶劑、載體、表面活性劑、填充劑等農業上合適的助劑）的組合或混合物。術語“農用化學成分”還包括術語“作物保護成分”和“製劑”。In the present invention, the term "agrochemical composition" refers to at least two active compounds and other agriculturally suitable additives (such as the above-mentioned solvents, carriers, surfactants, fillers and other agriculturally suitable auxiliaries) Combinations or mixtures. The term "agrochemical ingredients" also includes the terms "crop protection ingredients" and "formulations".
當使用新的農業化學組合物作為殺菌劑時，施用量可在相對較大的範圍內變化，這取決於施用的種類。在處理植物部分（例如葉）的情況下，施用量的範圍為0.1到10000g/公頃，優選10到1000g/公頃，更優選10到800g/公頃，還更優選50g/公頃到300g/公頃（在通過灌溉或滴灌施用的情況下，還可以降低施用量，尤其是當使用岩棉或珍珠岩等惰性基質時）；在種子處理的情況下施用量為每100 kg種子2到200 g，在土壤處理的情況下施用量為每公頃0.1到10000g，優選為1到5000g。When a new agrochemical composition is used as a fungicide, the application amount can vary within a relatively large range, depending on the kind of application. In the case of treating plant parts (such as leaves), the application rate ranges from 0.1 to 10000 g/ha, preferably 10 to 1000 g/ha, more preferably 10 to 800 g/ha, still more preferably 50 g/ha to 300 g/ha (in In the case of irrigation or drip irrigation, the application rate can also be reduced, especially when using inert substrates such as rock wool or perlite); in the case of seed treatment, the application rate is 2 to 200 g per 100 kg of seeds. In the case of treatment, the application rate is 0.1 to 10000 g per hectare, preferably 1 to 5000 g.
這些施用率僅作為示例，不對本發明施加任何限制。These application rates are only examples and do not impose any restrictions on the present invention.
使用者通常可以從預計量裝置、背負式噴霧器、噴霧罐、噴霧飛機或灌溉系統施用本發明的新型農用化學組合物。通常，農用化學組合物用水、緩衝劑和/或其他助劑製成所需的施用濃度，從而獲得本發明的即用噴霧液或農用化學組合物。通常，每公頃農業有用面積施用20至2000升，優選50至400升的即用噴霧液。The user can usually apply the new agrochemical composition of the present invention from a pre-metering device, a backpack sprayer, a spray can, a spray plane, or an irrigation system. Usually, the agrochemical composition is made into the required application concentration with water, buffer and/or other auxiliary agents, so as to obtain the ready-to-use spray liquid or agrochemical composition of the present invention. Generally, 20 to 2000 liters, preferably 50 to 400 liters of ready-to-use spray liquid are applied per hectare of agriculturally useful area.
根據一個實施方案，根據本發明的農用化學組合物的各個成分，例如試劑盒的部分或二元或三元混合物的部分，可以由使用者自己在噴霧罐或用於施用的任何其他種類的容器中混合（例如種子處理桶、種子制粒機、背負式噴霧器）。如果合適，可以添加其他助劑。According to one embodiment, the individual components of the agrochemical composition according to the present invention, such as part of a kit or part of a binary or ternary mixture, can be placed in a spray can or any other kind of container for application by the user himself Medium mixing (such as seed treatment bucket, seed granulator, knapsack sprayer). If appropriate, other additives can be added.
因此，本發明的一個實施方案是一種用於製備可用的農業化學組合物的試劑盒，該試劑盒包括：a）一種包含本文所定義的成分（1）和至少一種助劑的組合物；b）一種包含本文定義的成分（2）和至少一種助劑的組合物；任選地，c）一種包含至少本文定義的助劑和任選地另外的活性成分（3）的組合物。Therefore, one embodiment of the present invention is a kit for preparing a usable agrochemical composition, the kit comprising: a) a composition comprising the ingredients (1) defined herein and at least one adjuvant; b; ) A composition comprising the ingredient (2) defined herein and at least one adjuvant; optionally, c) a composition comprising at least the adjuvant defined herein and optionally an additional active ingredient (3).
本發明還涉及一種農用化學組合物，其包含至少一種式（I）化合物（成分1）和至少一種另外的用於植物保護的活性化合物的混合物，例如選自如上所述的組A）至P）（成分2），如果需要，可以加上一種合適的溶劑或固體載體。這些混合物在相同的施用量下均顯示出更高的抗有害真菌效率，因此特別有用。The present invention also relates to an agrochemical composition comprising a mixture of at least one compound of formula (I) (ingredient 1) and at least one additional active compound for plant protection, for example selected from groups A) to P as described above ) (Component 2), if necessary, a suitable solvent or solid carrier can be added. These mixtures all show higher efficiency against harmful fungi at the same application rate, so they are particularly useful.
此外，如上所述，用式（I）化合物和至少一種來自A）至P）組的殺真菌劑的混合物防治有害真菌比用單個式（I）化合物或A）至P）組中的單個殺菌劑防治那些真菌更有效。通過將式（I）的化合物與至少一種來自A）組至P）的活性化合物一起施用，可以獲得協同效果，即獲得的效果不僅僅簡單地增加了單個效果（增效混劑）。In addition, as described above, using a mixture of a compound of formula (I) and at least one fungicide from groups A) to P) to control harmful fungi is better than using a single compound of formula (I) or a single bactericidal agent in groups A) to P). Agents are more effective in controlling those fungi. By applying the compound of formula (I) together with at least one active compound from groups A) to P), a synergistic effect can be obtained, ie the effect obtained does not simply increase the single effect (synergistic mixture).
要獲得這種效果，可以將式（I）的化合物和至少一種其他活性化合物同時地（例如作為桶混物）或分開地或相繼地施用。在各個施用之間的時間間隔選擇方面，要確保在施用另外的一種或多種活性物質時，先施用的活性化合物仍以足夠的量存在於作用部位。施用的順序對於本發明不是很重要。To achieve this effect, the compound of formula (I) and at least one other active compound can be applied simultaneously (for example as a tank mix) or separately or sequentially. With regard to the selection of the time interval between each application, it is necessary to ensure that when another active substance or substances are administered, the active compound administered first is still present at the site of action in a sufficient amount. The order of application is not very important to the invention.
當按順序施用式（I）化合物和至少一種其他活性化合物時，兩次施用之間的時間可以在2小時到7天之間變化。同樣，更寬的範圍是0.25小時至30天，優選是0.5小時至14天，特別是1小時至7天或1.5小時至5天，還更優選是2小時至1天。When the compound of formula (I) and at least one other active compound are administered sequentially, the time between two applications can vary from 2 hours to 7 days. Likewise, the wider range is 0.25 hours to 30 days, preferably 0.5 hours to 14 days, especially 1 hour to 7 days or 1.5 hours to 5 days, and still more preferably 2 hours to 1 day.
在本發明的二元混合物和組合物中，式（I）化合物[成分（1）]和成分（2）的重量比通常取決於所用活性成分的性質，正常在1:10 000至10 000:1的範圍內。通常在1：100至100：1的範圍內，經常在1:50至50：1的範圍內，優選在1:20至20：1的範圍內，更優選在1：5至5：1的範圍內，特別情況下在1：2至2：1的範圍內。In the binary mixture and composition of the present invention, the weight ratio of the compound of formula (I) [component (1)] and component (2) usually depends on the nature of the active ingredient used, and is normally between 1:10 000 and 10 000: Within the range of 1. Usually in the range of 1:100 to 100:1, often in the range of 1:50 to 50:1, preferably in the range of 1:20 to 20:1, more preferably in the range of 1:5 to 5:1 Within the range, especially in the range of 1:2 to 2:1.
根據二元混合物和組合物的另一個實施方案，式（I）的化合物[成分1）]和成分2）的重量比通常在100：1至1：1的範圍內，經常在100:1至1:1的範圍內，通常在50:1至1:1的範圍內，優選在20:1至1:1的範圍內，更優選在5:1至1:1的範圍內，特別情況下是在2:1 至1：1的範圍內。According to another embodiment of the binary mixture and composition, the weight ratio of the compound of formula (I) [ingredient 1)] and component 2) is generally in the range of 100:1 to 1:1, often in the range of 100:1 to In the range of 1:1, usually in the range of 50:1 to 1:1, preferably in the range of 20:1 to 1:1, more preferably in the range of 5:1 to 1:1, in special cases It is in the range of 2:1 to 1:1.
根據二元混合物和組合物的另一個實施方案，式（I）的化合物[成分（1）]和成分（2）的重量比通常在1：1至1：1000的範圍內，經常在1：1至1：100的範圍內，通常在1：1至1:50的範圍內，優選在1：1至1:20的範圍內，更優選在1：1至1：5的範圍內，特別情況下在1：1至1：2的範圍內。According to another embodiment of the binary mixture and composition, the weight ratio of the compound of formula (I) [component (1)] to component (2) is usually in the range of 1:1 to 1:1000, often 1: In the range of 1 to 1:100, usually in the range of 1:1 to 1:50, preferably in the range of 1:1 to 1:20, more preferably in the range of 1:1 to 1:5, especially In this case, it is in the range of 1:1 to 1:2.
在三元混合物——包含式（I）的化合物[成分（1）]和成分（2）以及式（III）的化合物[成分（3）]的本發明的組合物中，式（I）化合物[成分（1）]和成分（2）的的重量比通常在1：100至100：1的範圍內，通常在1:50至50：1的範圍內，優選在20∶1至20∶1的範圍內，更優選在1∶5至5∶1的範圍內，特別情況下在1∶2至2∶1的範圍內。成分（1）和成分（3）的重量比通常在1：100至100：1的範圍內，通常在1:50至50：1的範圍內，優選在1:20至20：1的範圍內，更優選在1：5至5：1的範圍內，特別情況下在1：2至2：1的範圍內。In the ternary mixture-the composition of the present invention comprising the compound of formula (I) [ingredient (1)] and the component (2) and the compound of formula (III) [ingredient (3)], the compound of formula (I) The weight ratio of [component (1)] to component (2) is usually in the range of 1:100 to 100:1, usually in the range of 1:50 to 50:1, preferably 20:1 to 20:1 It is more preferably in the range of 1:5 to 5:1, and in particular in the range of 1:2 to 2:1. The weight ratio of ingredient (1) to ingredient (3) is usually in the range of 1:100 to 100:1, usually in the range of 1:50 to 50:1, preferably in the range of 1:20 to 20:1 , More preferably in the range of 1:5 to 5:1, especially in the range of 1:2 to 2:1.
優選的三元混合物包含選自組A)、B)、C)、D)、E)、F)、G)、H)、I)、J)、K)、L)、M)、N)、O)和 P)的化合物III作為殺真菌化合物；其中成分（3）的至少一種活性化合物III與成分（2）的至少一種活性化合物II不同。The preferred ternary mixture contains selected from the group A), B), C), D), E), F), G), H), I), J), K), L), M), N) , O) and P) compound III as fungicidal compounds; wherein at least one active compound III of component (3) is different from at least one active compound II of component (2).
如果需要，可以將任何其他活性成分以20∶1至1∶20的比例加入式（I）化合物[成分（1）]中。If necessary, any other active ingredient can be added to the compound of formula (I) [ingredient (1)] in a ratio of 20:1 to 1:20.
這些比例也適用於種子處理。These ratios also apply to seed treatment.
根據本發明的處理方法還提供了以同時、分開或按順序的方式使用或施用成分（1）和成分（2）。如果單一活性成分以順序方式施用（即在不同的時間施用），則可以在合理的時期（例如數小時或數天）內，一個接一個地施用它們。優選地，施加成分（1）和成分（2）的順序不會影響本發明的實施。The treatment method according to the present invention also provides for the use or application of ingredients (1) and (2) in a simultaneous, separate or sequential manner. If the single active ingredients are administered in a sequential manner (ie, at different times), they can be administered one after another within a reasonable period (for example, hours or days). Preferably, the order of applying component (1) and component (2) does not affect the implementation of the present invention.
在根據本發明的新型農用化學組合物中，成分（1）和成分（2）有利地、能發生協同作用的有效重量比在100∶1至1∶100的範圍內，優選在50∶1至1∶50的範圍內，更優選在20∶1至1∶20的範圍內，還更優選在10∶1至1∶10、5：1至1：5和2：1至1：2的範圍內。In the new agrochemical composition according to the present invention, the effective weight ratio of the component (1) and the component (2) which can produce a synergistic effect is in the range of 100:1 to 1:100, preferably in the range of 50:1 to In the range of 1:50, more preferably in the range of 20:1 to 1:20, still more preferably in the range of 10:1 to 1:10, 5:1 to 1:5, and 2:1 to 1:2 Inside.
本發明中公開的農業化學組合物的優選製劑可以具有以下組成成分（重量％）： a. 可乳化濃縮物： 活性組成成分：1至95%，優選60至90% 表面活性劑：1至30%，優選5至20% 液體載體：1至80%，優選1至35%The preferred formulation of the agrochemical composition disclosed in the present invention may have the following composition (% by weight): a. Emulsifiable concentrate: Active ingredient: 1 to 95%, preferably 60 to 90% Surfactant: 1 to 30%, preferably 5 to 20% Liquid carrier: 1 to 80%, preferably 1 to 35%
下面以實施例進一步說明本發明，但不對本發明施加任何限制。The following examples further illustrate the present invention, but do not impose any limitation on the present invention.
可以通過用水稀釋從該濃縮物中獲得可用於植物保護的任何需要的稀釋乳液。
下面以實施例進一步說明本發明，但不對本發明施加任何限制。The following examples further illustrate the present invention, but do not impose any limitation on the present invention.
通過將混合物與載體混合並在合適的磨機中研磨混合物，即可獲得即用型粉劑。這種粉劑也可以用於種子的幹拌料。
將細磨的組合與助劑充分混合，得到懸浮液濃縮物，然後用水稀釋就可以獲得任何所需稀釋度的懸浮液。使用這種稀釋液對活體植物以及植物繁殖材料進行噴霧、傾倒或浸沒等處理，可以保護其免受微生物侵染。
下面以實施例進一步說明本發明，但不對本發明施加任何限制。The following examples further illustrate the present invention, but do not impose any limitation on the present invention.
將組合物與助劑充分混合，並將混合物在合適的研磨機中充分研磨，得到可濕性粉劑，可將其用水稀釋以得到所需濃度的懸浮液。
下面以實施例進一步說明本發明，但不對本發明施加任何限制。The following examples further illustrate the present invention, but do not impose any limitation on the present invention.
將混合物與助劑混合並研磨，然後將混合物用水潤濕。將混合物擠出，然後在空氣流中乾燥。
將細磨的組合物在混合器中均勻地施加到用聚乙二醇潤濕的高嶺土上，得到無塵的包衣顆粒。
下面以實施例進一步說明本發明，但不對本發明施加任何限制。The following examples further illustrate the present invention, but do not impose any limitation on the present invention.
將該組合物與佐劑充分混合，並將混合物在合適的研磨機中充分研磨，得到可直接用於種子處理的粉末。
將細磨的組合與助劑充分混合，得到懸浮液濃縮物，然後用水稀釋就可以獲得任何所需稀釋度的懸浮液。使用這種稀釋液對活體植物以及植物繁殖材料進行噴霧、傾倒或浸沒等處理，可以保護其免受微生物侵染。
將28份混合物與2份芳族溶劑和7份甲苯二異氰酸酯/聚亞甲基-聚苯基異氰酸酯混合物（8∶1）混合。將該混合物在1.2份聚乙烯醇、0.05份消泡劑和51.6份水的混合物中乳化，直到獲得所需的細微性。向該乳液中加入2.8份1,6-二氨基己烷溶於5.3份水中的混合物。攪拌混合物直至聚合反應完成。通過添加0.25份的增稠劑和3份的分散劑來穩定所獲得的膠囊懸浮液。膠囊懸浮液製劑包含28％的活性成分。中等的膠囊直徑是8-15微米。在適合於該目的的設備中將所得製劑以水性懸浮液形式施用於種子。Combine 28 parts of the mixture with 2 parts of aromatic solvent and 7 parts of toluene diisocyanate/polymethylene-polyphenyl isocyanate mixture (8:1). This mixture is emulsified in a mixture of 1.2 parts of polyvinyl alcohol, 0.05 parts of defoamer and 51.6 parts of water until the desired fineness is obtained. To this emulsion was added a mixture of 2.8 parts of 1,6-diaminohexane dissolved in 5.3 parts of water. The mixture is stirred until the polymerization reaction is complete. The obtained capsule suspension was stabilized by adding 0.25 parts of thickener and 3 parts of dispersant. The capsule suspension formulation contains 28% of the active ingredient. The medium capsule diameter is 8-15 microns. The resulting formulation is applied to the seed in the form of an aqueous suspension in a device suitable for this purpose.
包含式（I）的化合物[成分（1）]和成分（2）的組合物可以顯示協同作用。The composition comprising the compound of formula (I) [ingredient (1)] and the component (2) may exhibit a synergistic effect.
根據本發明，只要活性組合成分的功效大於各個成分的功效之和，給定活性成分組合的預期活性E遵循所謂的COLBY公式。According to the present invention, as long as the efficacy of the active combination ingredients is greater than the sum of the effects of the individual ingredients, the expected activity E of a given combination of active ingredients follows the so-called COLBY formula.
功效為0表示處理後的植物的感染水準與未處理的對照植物的感染水準差不多；功效為100表示處理過的植物未受感染。An efficacy of 0 indicates that the infection level of the treated plant is similar to that of the untreated control plant; an efficacy of 100 indicates that the treated plant is not infected.
可以使用Colby公式（COLBY，S.R.“計算除草劑組合的協同和拮抗作用”，《Weeds》第15卷，第20-22頁；1967）確定活性化合物組合的預期功效。Colby 公式： The Colby formula (COLBY, SR "Calculating the synergistic and antagonistic effects of herbicide combinations", Weeds, vol. 15, pages 20-22; 1967) can be used to determine the expected efficacy of a combination of active compounds. Colby formula:
給定兩種活性化合物（二元組合物）的組合的預期活性可計算如下：
三種活性化合物（三元組合物）的給定組合的預期活性可計算如下：
式(I)化合物的製備已在各種檔描述，如現有技術檔WO2018069841及其參考文獻中有描述，或通過至少一種下列方案(1)至(3)的合成途徑來製備： 方案 1 
化合物1是合成式（I）化合物的重要中間體。文獻中描述了合成式（I）化合物的各種方法，如：Compound 1 is an important intermediate for the synthesis of the compound of formula (I). Various methods of synthesizing the compound of formula (I) are described in the literature, such as:
方法1：根據《Helvitachimica Act XXIX》（1946），第1413-1424頁，以及《四面體》，2000，56，第7199-7203頁所述，使用催化劑氯化鋅（ZnCl2 ）或氯化鋁（AlCl3 ）用相應的苯甲醯氯獲得。Method 1: According to "Helvitachimica Act XXIX" (1946), pages 1413-1424, and "Tetrahedron", 2000, 56, pages 7199-7203, use the catalyst zinc chloride (ZnCl 2 ) or aluminum chloride (AlCl 3 ) is obtained with the corresponding benzyl chloride.
方法2：在酸催化劑如（a）如《四面體》（2000，56，第7199-7203頁）中所述的三氟甲烷磺酸；（b）《合成》（2004，13，第2165-2168頁）中所述的石墨和甲磺酸；（c）《Helvetiva Chimica Act》（2005，88，第2282-2287頁）中所述的石墨和對甲苯磺酸；（d）如《合成》（2000，10，第1427-1430頁）中所述的1-全氟丁烷磺酸的存在下，用相應的苯甲酸獲得。Method 2: In an acid catalyst such as (a) trifluoromethanesulfonic acid as described in "Tetrahedron" (2000, 56, p. 7199-7203); (b) "Synthesis" (2004, 13, p. 2165- Graphite and methanesulfonic acid described in page 2168); (c) Graphite and p-toluenesulfonic acid described in "Helvetiva Chimica Act" (2005, 88, pages 2282-2287); (d) such as "Synthesis" (2000, 10, pages 1427-1430), in the presence of 1-perfluorobutane sulfonic acid, obtained with the corresponding benzoic acid.
方法3：如《綠色化學》（4（2002），第129-133頁或《四面體》（56（2000），第663-6465頁）或《日本化學學會公報》（2000，73，第2325-2333頁）所述，在三氟甲基磺酸銅，三氟甲磺酸鎵或三氟甲磺酸銻或三氟甲磺酸鐿或三氟甲磺酸鈧或三氟甲磺酸鉍的存在下，用苯甲酸的相應衍生物來獲得。Method 3: Such as "Green Chemistry" (4 (2002), p. 129-133 or "Tetrahedron" (56 (2000), p. 663-6465) or "Journal of the Chemical Society of Japan" (2000, 73, p. 2325) -2333) as described in copper triflate, gallium triflate or antimony triflate or ytterbium triflate or scandium triflate or bismuth triflate In the presence of the corresponding derivatives of benzoic acid to obtain.
方法4：如《四面體通訊》（2008，49，第6715-6719頁）中所述，在五氧化二磷（P2
O5
）本身或吸附在矽膠上的情況下用相應的取代苯甲酸獲得。 方案 2 
可以按照方案1中所述的相同方法使用適當取代的式2a化合物合成式（I）化合物。相應的中間體2a可以按照《有機化學雜誌》（1983, 48, 4097-98）、《有機化學雜誌》（1983, 48, 4087-4096）中所述的方法，在鹼（如氫氧化鈉或叔丁基鈉或氫化鈉）存在下與苯乙腈反應，然後在氫氧化鉀水溶液存在下，用過氧化氫/間氯過苯甲酸氧化來合成。 方案 3 
式（I）化合物也可按照《生物有機化學與醫藥化學通訊》（2004，14（4），第1023-1026頁）中所述的方法使用鈴木反應合成，方法是用相應的取代苄基鹵化物處理式6化合物。式6化合物可通過在二氧六環中使用乙酸鈀和[1,1'-雙（二苯基膦）二茂鐵]鈀（II）二氯[PdCl2 （dppf）]二氯甲烷絡合物處理溴代衍生物5來合成，產率良好。化學實例： The compound of formula (I) can also be synthesized using the Suzuki reaction according to the method described in "Communications of Bioorganic Chemistry and Medicinal Chemistry" (2004, 14(4), pages 1023-1026), and the method is to use the corresponding substituted benzyl halide The compound of formula 6 was treated. The compound of formula 6 can be complexed by using palladium acetate and [1,1'-bis(diphenylphosphine)ferrocene]palladium(II)dichloro[PdCl 2 (dppf)] dichloromethane in dioxane The brominated derivative 5 was synthesized by chemical treatment, and the yield was good. Chemical examples:
下列具有代表性的示例闡述了製造本發明化合物的方式和過程，包括發明者為實施本發明所設想的最佳方式，但不對本發明化合物施加任何限制。The following representative examples illustrate the methods and processes of manufacturing the compounds of the present invention, including the best mode contemplated by the inventors for implementing the present invention, but do not impose any restrictions on the compounds of the present invention.
例example 11 ：: N'-(2,5-N'-(2,5- 二甲基Dimethyl -4-(2--4-(2- 甲基苄基Methylbenzyl )) 苯基Phenyl )-N-)-N- 乙基Ethyl -N--N- 甲基甲醯胺的製備：Preparation of methyl formamide:
第NS AA 步：step: N-(2,5-N-(2,5- 二甲基苯基Dimethyl phenyl )) 乙醯胺製備：Acetamide preparation:
在0℃下向2,5-二甲基苯胺（50g，413mmol）的1,2-二氯甲烷（500mL）攪拌溶液中加入三乙胺（144mL，1031mmol）和乙醯氯（35.2mL，495mmol）。將所得反應混合物在0℃下攪拌2小時。反應完成後，將反應混合物倒入冰水中。將水層用1,2-二氯甲烷（1000mL）萃取三次。分離二氯甲烷層，用水（500mL）和鹽水溶液（250mL）洗滌兩次。分離有機層，用無水硫酸鈉乾燥，過濾並在高真空下蒸發，得到所需的N-（2,5-二甲基苯基）乙醯胺。(60 g，368 mmol，89%產率)。LCMS (M+H): 165.50.To a stirred solution of 2,5-dimethylaniline (50g, 413mmol) in 1,2-dichloromethane (500mL) at 0°C was added triethylamine (144mL, 1031mmol) and acetyl chloride (35.2mL, 495mmol) ). The resulting reaction mixture was stirred at 0°C for 2 hours. After the reaction was completed, the reaction mixture was poured into ice water. The aqueous layer was extracted three times with 1,2-dichloromethane (1000 mL). The dichloromethane layer was separated and washed twice with water (500 mL) and brine solution (250 mL). The organic layer was separated, dried over anhydrous sodium sulfate, filtered and evaporated under high vacuum to obtain the desired N-(2,5-dimethylphenyl)acetamide. (60 g, 368 mmol, 89% yield). LCMS (M+H): 165.50.
第NS BB 步：step: N-(2,5-N-(2,5- 二甲基Dimethyl -4-(2--4-(2- 甲基苯甲醯基Methylbenzyl )) 苯基Phenyl )) 乙醯胺的製備Preparation of Acetamide
將N-（2,5-二甲基苯基）乙醯胺（50g，306 mmol）、氯化鋁（102 g，766 mmol）和2-甲基苯甲醯氯（100 ml，766 mmol）的混合物混合在一起並加熱至100°C，直到反應完成。反應完成後，將反應混合物用1mol/L的鹽酸液（約250mL，直至獲得透明溶液）淬滅，然後用1，2-二氯甲烷（500mL）萃取兩次。將合併的有機層用鹽水（250mL）洗滌兩次，用無水硫酸鈉乾燥，然後將其過濾並且在減壓下濃縮。然後將殘餘物通過矽膠柱色譜純化（使用己烷的乙酸乙酯溶液作為洗脫劑），得到所需的N N-(2,5-二甲基-4-(2-甲基苄基)苯基)乙醯胺 (70 g，249 mmol，81%產率)，為固體。LCMS (M+H): 281.4.Combine N-(2,5-dimethylphenyl)acetamide (50g, 306 mmol), aluminum chloride (102 g, 766 mmol) and 2-methylbenzyl chloride (100 ml, 766 mmol) The mixture is mixed together and heated to 100°C until the reaction is complete. After the reaction was completed, the reaction mixture was quenched with 1 mol/L hydrochloric acid solution (about 250 mL, until a clear solution was obtained), and then extracted twice with 1,2-dichloromethane (500 mL). The combined organic layer was washed twice with brine (250 mL), dried over anhydrous sodium sulfate, then it was filtered and concentrated under reduced pressure. The residue was then purified by silica gel column chromatography (using hexane in ethyl acetate as the eluent) to obtain the desired N N-(2,5-dimethyl-4-(2-methylbenzyl) Phenyl)acetamide (70 g, 249 mmol, 81% yield) as a solid. LCMS (M+H): 281.4.
第NS CC 步：step: N-(2,5-N-(2,5- 二甲基Dimethyl -4-(2--4-(2- 甲基苄基Methylbenzyl )) 苯基Phenyl )) 乙醯胺的製備Preparation of Acetamide
在0℃下，向N-(2,5-二甲基-4-(2-甲基苯甲醯基)苯基)乙醯胺 (35 g，124 mmol)的乙腈（15 mL）懸浮液中加入三乙基矽烷（79 mL，498 mmol）和三氟化硼醚化物（63.1mL，498mmol），持續10分鐘。加完後，將反應混合物在25℃下攪拌36小時。反應完成後，將反應混合物用固體碳酸氫鈉中和，然後用二氯甲烷（200mL）萃取三次。合併的有機層用無水硫酸鈉乾燥。將混合物過濾並在減壓下濃縮。然後將殘餘物通過矽膠柱色譜法（使用己烷的乙酸乙酯溶液作為洗脫劑）純化，得到所需的N-(2,5-二甲基-4-(2-甲基苄基)苯基)乙醯胺 (12 g，44.9 mmol，36.1%產率)，為白色固體。LCMS (M+H) 268.3.To a suspension of N-(2,5-dimethyl-4-(2-methylbenzyl)phenyl)acetamide (35 g, 124 mmol) in acetonitrile (15 mL) at 0°C Add triethylsilane (79 mL, 498 mmol) and boron trifluoride etherate (63.1 mL, 498 mmol) for 10 minutes. After the addition was complete, the reaction mixture was stirred at 25°C for 36 hours. After the reaction was completed, the reaction mixture was neutralized with solid sodium bicarbonate, and then extracted three times with dichloromethane (200 mL). The combined organic layer was dried over anhydrous sodium sulfate. The mixture was filtered and concentrated under reduced pressure. The residue was then purified by silica gel column chromatography (using hexane in ethyl acetate as the eluent) to obtain the desired N-(2,5-dimethyl-4-(2-methylbenzyl) Phenyl)acetamide (12 g, 44.9 mmol, 36.1% yield) as a white solid. LCMS (M+H) 268.3.
第NS DD 步：step: 2,5-2,5- 二甲基Dimethyl -4--4- （( 2-2- 甲基苄基）苯胺的製備：Preparation of methylbenzyl) aniline:
在25℃下，向N-（2,5-二甲基-4-（2-甲基苄基）苯基）乙醯胺（24 g，90 mmol）的乙醇（200 mL）懸浮液中加入氫氧化鈉（108 g，2693 mmol）水（200mL）水溶液，並將反應混合物加熱至回流（100℃），持續36小時。反應完成後，將反應混合物冷卻至25℃，並用二氯甲烷萃取。合併的有機層用無水硫酸鈉乾燥。然後將反應混合物過濾並在減壓下蒸發。然後將殘餘物通過矽膠柱色譜法（使用己烷的乙酸乙酯作為洗脫劑）純化，得到所需的2,5-二甲基-4-（2-甲基苄基）苯胺（13.5 g，59.9 mmol，66.7％產率），白色固體。LCMS (M+H) 226.34.At 25°C, add to a suspension of N-(2,5-dimethyl-4-(2-methylbenzyl)phenyl)acetamide (24 g, 90 mmol) in ethanol (200 mL) Sodium hydroxide (108 g, 2693 mmol) in water (200 mL) in water, and the reaction mixture was heated to reflux (100°C) for 36 hours. After the reaction was completed, the reaction mixture was cooled to 25°C and extracted with dichloromethane. The combined organic layer was dried over anhydrous sodium sulfate. The reaction mixture was then filtered and evaporated under reduced pressure. The residue was then purified by silica gel column chromatography (using hexane and ethyl acetate as the eluent) to obtain the desired 2,5-dimethyl-4-(2-methylbenzyl)aniline (13.5 g , 59.9 mmol, 66.7% yield), white solid. LCMS (M+H) 226.34.
第NS EE 步：step: N'-(2,5-N'-(2,5- 二甲基Dimethyl -4-(2--4-(2- 甲基苄基Methylbenzyl )) 苯基Phenyl )-N-)-N- 乙基Ethyl -N--N- 甲基甲醯胺的製備Preparation of methyl formamide
在103°C下，將2,5-二甲基-4-（2-甲基苄基）苯胺（7 g，31.1 mmol）的原甲酸三甲酯（130 ml）和對甲苯磺酸一水合物（0.591 g，3.11 mmol）溶液攪拌4小時。將反應混合物在減壓下濃縮以獲得中間體，然後將其溶於1,4-二惡烷（100mL）中。向所得混合物中加入N-乙基甲胺（13.50ml，155mmol），並將反應混合物在103℃加熱2小時。反應完成後，將反應混合物在減壓下濃縮以獲得殘餘物，然後將其通過矽膠柱色譜法（使用己烷的乙酸乙酯溶液作為洗脫劑）純化，得到所需的N'-(2,5-二甲基-4-(2-甲基苄基)苯基)-N-乙基-N-甲基甲醯胺(7 g，23.77 mmol，77%產率)。1 H-NMR(400 MHz, DMSO-d6) δ 7.59 (s, 1H), 7.17-7.14 (m, 1H), 7.10-7.03 (m, 2H), 6.80-6.77 (m, 1H), 6.59 (d,2H), 3.78 (d,2H),3.42-3.35 (m, 1H), 3.29 (s, 1H), 2.90 (s, 3H), 2.22 (s, 3H), 2.09 (s, 3H), 2.04 (s, 3H), 1.10 (t, 3H); (M+1):295.1.生物實例： At 103°C, 2,5-dimethyl-4-(2-methylbenzyl)aniline (7 g, 31.1 mmol) in trimethyl orthoformate (130 ml) and p-toluenesulfonic acid monohydrate The solution of the product (0.591 g, 3.11 mmol) was stirred for 4 hours. The reaction mixture was concentrated under reduced pressure to obtain an intermediate, which was then dissolved in 1,4-dioxane (100 mL). To the resulting mixture was added N-ethylmethylamine (13.50ml, 155mmol), and the reaction mixture was heated at 103°C for 2 hours. After the completion of the reaction, the reaction mixture was concentrated under reduced pressure to obtain a residue, which was then purified by silica gel column chromatography (using hexane in ethyl acetate as the eluent) to obtain the desired N'-(2 ,5-Dimethyl-4-(2-methylbenzyl)phenyl)-N-ethyl-N-methylformamide (7 g, 23.77 mmol, 77% yield). 1 H-NMR(400 MHz, DMSO-d6) δ 7.59 (s, 1H), 7.17-7.14 (m, 1H), 7.10-7.03 (m, 2H), 6.80-6.77 (m, 1H), 6.59 (d ,2H), 3.78 (d,2H),3.42-3.35 (m, 1H), 3.29 (s, 1H), 2.90 (s, 3H), 2.22 (s, 3H), 2.09 (s, 3H), 2.04 ( s, 3H), 1.10 (t, 3H); (M+1):295.1. Biological examples:
如本文所述，式（I）化合物顯示出極高的殺蟲活性，其對許多攻擊重要農作物的害蟲有效。下列試驗將評估本發明化合物的活性：植物活體生物試驗實例 As described herein, the compound of formula (I) shows extremely high insecticidal activity, which is effective against many pests that attack important crops. The following tests will evaluate the activity of the compounds of the present invention: Examples of Living Plant Biological Tests
進一步選擇化合物進行體內（溫室）預防/治療試驗。檢查化合物對病原體的預防/治療效果的方法如下：Further select compounds for in vivo (greenhouse) prevention/treatment tests. The methods to check the preventive/therapeutic effects of compounds on pathogens are as follows:
例example AA ：水稻稻瘟病菌試驗：Test of rice blast fungus
將單個化合物或相應的化合物組合溶解在2％的二甲基亞碸/丙酮中，然後與含乳化劑的水混合至50 mL的校準噴霧量。將測試溶液倒入噴霧瓶中用以進一步應用。A single compound or a corresponding combination of compounds was dissolved in 2% dimethyl sulfoxide/acetone, and then mixed with emulsifier-containing water to a calibrated spray volume of 50 mL. Pour the test solution into a spray bottle for further application.
為了測試化合物的防病活性，使用空心圓錐噴嘴在噴霧櫃內以所述的施用率往溫室中培養的健康幼齡水稻噴灑活性化合物製劑。處理後一天，用含有1.4x106 的致病疫黴接種物的孢子懸浮液接種植物。然後將接種的植物保存在溫度為24℃、相對濕度為95％的溫室中以進行疾病表達。In order to test the anti-disease activity of the compound, a hollow cone nozzle was used to spray the active compound preparation on healthy young rice grown in the greenhouse at the stated application rate in a spray cabinet. One day after treatment, inoculated with a spore suspension containing plants of Phytophthora infestans inoculum of 1.4x10 6. The inoculated plants are then stored in a greenhouse at a temperature of 24°C and a relative humidity of 95% for disease expression.
通過在施用後3,7,10和15天對處理植物的疾病嚴重性（0-100％規模）進行評級來進行化合物性能的視覺評估。通過比較治療中的疾病評級與未處理對照之一來計算單個化合物和混合物的功效（％控制率）。並通過記錄壞死、萎黃和生長遲緩等症狀評估化合物的植物相容性。Visual assessment of compound performance was performed by grading the disease severity (0-100% scale) of the treated plants at 3, 7, 10, and 15 days after application. The efficacy (% control rate) of individual compounds and mixtures is calculated by comparing the disease rating under treatment with one of the untreated controls. The phytocompatibility of the compound was evaluated by recording symptoms such as necrosis, chlorosis, and growth retardation.
表A：本發明組合物對水稻中的稻瘟病菌的協同殺菌活性，其中代表性的式（I）化合物是作為成分（1）的化合物（I-2）、化合物（I-6）和化合物（I-7）以及成分（2），如下表所示：
例example BB ：番茄鏈格孢菌實驗: Tomato Alternaria test
將單個化合物或相應的化合物組合溶解在2％的二甲基亞碸/丙酮中，然後與含乳化劑的水混合至50 mL的校準噴霧量。將測試溶液倒入噴霧瓶中用以進一步應用。A single compound or a corresponding combination of compounds was dissolved in 2% dimethyl sulfoxide/acetone, and then mixed with emulsifier-containing water to a calibrated spray volume of 50 mL. Pour the test solution into a spray bottle for further application.
為了測試化合物的防病活性，使用空心圓錐噴嘴在噴霧櫃內以所述的施用率往溫室中培養的健康幼齡番茄噴灑活性化合物製劑。處理後一天，用含有0.24x106 的鏈格孢菌和2%的麥芽接種物的孢子懸浮液接種植物。然後將接種的植物保存在溫度為22-24℃、相對濕度為90-95％的溫室中以進行疾病表達。In order to test the compound's disease-preventing activity, a hollow cone nozzle was used to spray the active compound preparation on healthy young tomatoes grown in the greenhouse at the stated application rate in a spray cabinet. One day after the treatment, the plants were inoculated with a spore suspension containing 0.24×10 6 Alternaria spp and 2% malt inoculum. The inoculated plants are then stored in a greenhouse at a temperature of 22-24° C. and a relative humidity of 90-95% for disease expression.
通過在施用後3,7,10和15天對處理植物的疾病嚴重性（0-100％規模）進行評級來進行化合物性能的視覺評估。通過比較治療中的疾病評級與未處理對照之一來計算單個化合物和混合物的功效（％控制率）。並通過記錄壞死、萎黃和生長遲緩等症狀評估化合物的植物相容性。Visual assessment of compound performance was performed by grading the disease severity (0-100% scale) of the treated plants at 3, 7, 10, and 15 days after application. The efficacy (% control rate) of individual compounds and mixtures is calculated by comparing the disease rating under treatment with one of the untreated controls. The phytocompatibility of the compound was evaluated by recording symptoms such as necrosis, chlorosis, and growth retardation.
表B：本發明組合物對番茄鏈格孢菌的協同殺菌活性，其中代表性的式（I）化合物是作為成分（1）的化合物（I-2）、化合物（I-6）和化合物（I-7）以及成分（2），如下表所示：
例example CC ：黃瓜白粉病菌實驗: Cucumber Powdery Mildew Test
將單個化合物或相應的化合物組合溶解在2％的二甲基亞碸/丙酮中，然後與含乳化劑的水混合至50 mL的校準噴霧量。將測試溶液倒入噴霧瓶中用以進一步應用。A single compound or a corresponding combination of compounds was dissolved in 2% dimethyl sulfoxide/acetone, and then mixed with emulsifier-containing water to a calibrated spray volume of 50 mL. Pour the test solution into a spray bottle for further application.
為了測試化合物的防病活性，使用空心圓錐噴嘴在噴霧櫃內以所述的施用率往溫室中培養的健康幼齡黃瓜噴灑活性化合物製劑。處理後一天，用含有2x105 白粉病菌的孢子懸浮液接種植物。然後將接種的植物保存在溫度為22-24℃、相對濕度為50-60％的溫室中以進行疾病表達。In order to test the anti-disease activity of the compound, a hollow cone nozzle was used to spray the active compound preparation on healthy young cucumbers cultivated in the greenhouse at the stated application rate in a spray cabinet. One day after the treatment, the plants were inoculated with a spore suspension containing 2×10 5 powdery mildew fungi. The inoculated plants are then stored in a greenhouse at a temperature of 22-24° C. and a relative humidity of 50-60% for disease expression.
通過在施用後3,7,10和15天對處理植物的疾病嚴重性（0-100％規模）進行評級來進行化合物性能的視覺評估。通過比較治療中的疾病評級與未處理對照之一來計算化合物的功效（％控制率）。並通過記錄壞死、萎黃和生長遲緩等症狀評估化合物的植物相容性。Visual assessment of compound performance was performed by grading the disease severity (0-100% scale) of the treated plants at 3, 7, 10, and 15 days after application. The efficacy of the compound (% control rate) is calculated by comparing the rating of the disease under treatment with one of the untreated controls. The phytocompatibility of the compound was evaluated by recording symptoms such as necrosis, chlorosis, and growth retardation.
表C：本發明組合物對黃瓜白粉病菌的協同殺菌活性，其中代表性的式（I）化合物是作為成分（1）的化合物（I-2）、化合物（I-6）和化合物（I-7）以及成分（2），如下表所示：
例example DD ：大豆豆薯層鏽菌實驗：Puccinia test
將單個化合物或相應的化合物組合溶解在2％的二甲基亞碸/丙酮中，然後與含乳化劑的水混合至50 mL的校準噴霧量。將測試溶液倒入噴霧瓶中用以進一步應用。A single compound or a corresponding combination of compounds was dissolved in 2% dimethyl sulfoxide/acetone, and then mixed with emulsifier-containing water to a calibrated spray volume of 50 mL. Pour the test solution into a spray bottle for further application.
為了測試化合物的防病活性，使用空心圓錐噴嘴在噴霧櫃內以所述的施用率往溫室中培養的健康幼齡大豆噴灑活性化合物製劑。處理後一天，用含有2x105 豆薯層鏽菌的孢子懸浮液接種植物。然後將接種的植物保存在溫度為22-24℃、相對濕度為80-90％的溫室中以進行疾病表達。In order to test the anti-disease activity of the compound, a hollow cone nozzle was used to spray the active compound preparation on healthy young soybeans cultivated in the greenhouse at the stated application rate in a spray cabinet. One day after the treatment, the plants were inoculated with a spore suspension containing 2×10 5 Puccinia vulgaris. The inoculated plants are then stored in a greenhouse at a temperature of 22-24° C. and a relative humidity of 80-90% for disease expression.
通過在施用後3,7,10和15天對處理植物的疾病嚴重性（0-100％規模）進行評級來進行化合物性能的視覺評估。通過比較治療中的疾病評級與未處理對照之一來計算化合物的功效（％控制率）。並通過記錄壞死、萎黃和生長遲緩等症狀評估化合物的植物相容性。Visual assessment of compound performance was performed by grading the disease severity (0-100% scale) of the treated plants at 3, 7, 10, and 15 days after application. The efficacy of the compound (% control rate) is calculated by comparing the rating of the disease under treatment with one of the untreated controls. The phytocompatibility of the compound was evaluated by recording symptoms such as necrosis, chlorosis, and growth retardation.
表D：本發明組合物對大豆豆薯層鏽菌的協同殺菌活性，其中代表性的式（I）化合物是作為成分（1）的化合物（I-2）、化合物（I-6）和化合物（I-7）以及成分（2），如下表所示：
例example EE ：小麥穎枯殼針孢實驗：Wheat spicules test
將單個化合物或相應的化合物組合溶解在2％的二甲基亞碸/丙酮中，然後與含乳化劑的水混合至50 mL的校準噴霧量。將測試溶液倒入噴霧瓶中用以進一步應用。A single compound or a corresponding combination of compounds was dissolved in 2% dimethyl sulfoxide/acetone, and then mixed with emulsifier-containing water to a calibrated spray volume of 50 mL. Pour the test solution into a spray bottle for further application.
為了測試化合物的防病活性，使用空心圓錐噴嘴在噴霧櫃內以所述的施用率往溫室中培養的健康幼齡小麥噴灑活性化合物製劑。處理後一天，用含有2.8x106 穎枯殼針孢的孢子懸浮液接種植物。然後將接種的植物保存在溫度為22-25℃、相對濕度為90-100％的溫室中以進行疾病表達。In order to test the anti-disease activity of the compound, a hollow cone nozzle was used to spray the active compound preparation in a spray cabinet at the stated application rate on healthy young wheat grown in the greenhouse. One day after the treatment, the plants were inoculated with a spore suspension containing 2.8×10 6 Needle spores. The inoculated plants are then stored in a greenhouse at a temperature of 22-25° C. and a relative humidity of 90-100% for disease expression.
通過在施用後3，7，10天對處理植物的疾病嚴重性（0-100％規模）進行評級來進行化合物和化合物組合物性能的視覺評估。通過比較治療中的疾病評級與未處理對照之一來計算化合物的功效（％控制率）。並通過記錄壞死、萎黃和生長遲緩等症狀評估化合物的植物相容性。Visual assessment of the performance of the compound and compound composition was performed by grading the disease severity (0-100% scale) of the treated plants 3, 7, 10 days after application. The efficacy of the compound (% control rate) is calculated by comparing the rating of the disease under treatment with one of the untreated controls. The phytocompatibility of the compound was evaluated by recording symptoms such as necrosis, chlorosis, and growth retardation.
表E：本發明組合物對小麥穎枯殼針孢的協同殺菌活性，其中代表性的式（I）化合物是作為成分（1）的化合物（I-2）、化合物（I-6）和化合物（I-7）以及成分（2），如下表所示：
在參考某些優選實施例描述本發明後，本領域技術人員應該很熟悉其他實施例。對於本領域技術人員而言，可以在不脫離本發明範圍的情況下實施對材料和方法的許多修改。After describing the present invention with reference to certain preferred embodiments, those skilled in the art should be familiar with other embodiments. For those skilled in the art, many modifications to materials and methods can be implemented without departing from the scope of the present invention.
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| US4272417A (en) | 1979-05-22 | 1981-06-09 | Cargill, Incorporated | Stable protective seed coating |
| US4245432A (en) | 1979-07-25 | 1981-01-20 | Eastman Kodak Company | Seed coatings |
| US4808430A (en) | 1987-02-27 | 1989-02-28 | Yazaki Corporation | Method of applying gel coating to plant seeds |
| DE3939503A1 (en) | 1989-11-30 | 1991-06-06 | Hoechst Ag | NEW PYRAZOLINE FOR THE PROTECTION OF CULTURAL PLANTS AGAINST HERBICIDES |
| US5876739A (en) | 1996-06-13 | 1999-03-02 | Novartis Ag | Insecticidal seed coating |
| US6503904B2 (en) | 1998-11-16 | 2003-01-07 | Syngenta Crop Protection, Inc. | Pesticidal composition for seed treatment |
| GB9902592D0 (en) | 1999-02-06 | 1999-03-24 | Hoechst Schering Agrevo Gmbh | Fungicides |
| US6660690B2 (en) | 2000-10-06 | 2003-12-09 | Monsanto Technology, L.L.C. | Seed treatment with combinations of insecticides |
| US20020134012A1 (en) | 2001-03-21 | 2002-09-26 | Monsanto Technology, L.L.C. | Method of controlling the release of agricultural active ingredients from treated plant seeds |
| FR2829362B1 (en) | 2001-09-10 | 2003-11-07 | Aventis Cropscience Sa | FUNGICIDAL COMPOSITION BASED ON ARYLAMIDINE DERIVATIVES AND KNOWN FUNGICIDAL COMPOUNDS |
| JP2005524706A (en) | 2002-05-03 | 2005-08-18 | イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニー | Amidinylphenyl compounds, their use as fungicides and fungicides |
| EP1570736A1 (en) | 2004-03-05 | 2005-09-07 | Bayer CropScience S.A. | Fungicide composition comprising an arylamidine derivative and known fungicide compounds |
| EP1931200A1 (en) | 2005-09-13 | 2008-06-18 | Bayer CropScience AG | Fungicide composition comprising an arylamidine derivative and two known fungicide compounds |
| EP2223917A1 (en) | 2009-02-02 | 2010-09-01 | Bayer CropScience AG | Isothiazolyloxyphenylamidines and their use as fungicides |
| EP2892341B1 (en) * | 2012-09-07 | 2017-04-26 | Bayer CropScience AG | Active compound combinations |
| WO2015121802A1 (en) | 2014-02-12 | 2015-08-20 | Isagro S.P.A. | Benzoylphenyl-formamidines having a fungicidal activity, their agronomic compositions and relative use |
| EP3011832A1 (en) * | 2015-06-15 | 2016-04-27 | Bayer CropScience AG | Fungicidal combination comprising phenoxyphenylamidines and further fungicide |
| MX2018007292A (en) | 2015-12-15 | 2018-09-06 | Syngenta Participations Ag | Microbiocidal phenylamidine derivatives. |
| CA3040438A1 (en) | 2016-10-14 | 2018-04-19 | Pi Industries Ltd | 4-substituted phenylamine derivatives and their use to protect crops by fighting undesired phytopathogenic micoorganisms |
| EP3541779B1 (en) | 2016-11-15 | 2020-12-23 | Syngenta Participations AG | Microbiocidal phenylamidine derivatives |
| BR112019012272A2 (en) | 2016-12-14 | 2019-12-03 | Bayer Ag | phenylamidines and their use as fungicides |
| WO2018211442A1 (en) * | 2017-05-18 | 2018-11-22 | Pi Industries Ltd. | Formimidamidine compounds useful against phytopathogenic microorganisms |
| JP2020523382A (en) | 2017-06-14 | 2020-08-06 | シンジェンタ パーティシペーションズ アーゲー | Sterilizing and fungicidal composition |
| BR112020020959A2 (en) * | 2018-04-16 | 2021-01-19 | Pi Industries Ltd. | USE OF PHENYLAMIDINE 4-SUBSTITUTED COMPOUNDS TO CONTROL RUST DISEASES IN VEGETABLES |
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