TW201720819A - Molecules having pesticidal utility, and intermediates, compositions, and processes, related thereto - Google Patents

Abstract

This disclosure relates to the field of molecules having pesticidal utility against pests in Phyla Arthropoda, Mollusca, and Nematoda, processes to produce such molecules, intermediates used in such processes, pesticidal compositions containing such molecules, and processes of using such pesticidal compositions against such pests. These pesticidal compositions may be used, for example, as acaricides, insecticides, miticides, molluscicides, and nematicides. This document discloses molecules having the following formula ("Formula One").

Description

Molecules with insecticidal effects and related intermediates, compositions and methods (3)

FIELD OF THE INVENTION This disclosure relates to the following fields: molecules having insecticidal effects against arthropods, mollusc doors, and pests of round animal gates, methods of producing such molecules, intermediates used in such methods An insecticidal composition containing such molecules, and a method of using such insecticidal molecules against such pests. These insecticidal compositions can be used, for example, as acaricides, insecticides, acaricides, molluscicides, and nematicides.

BACKGROUND OF THE INVENTION "There are many of the most dangerous human diseases that are transmitted by insect vectors" (Rivero et al.). Historically, malaria, dengue fever, yellow fever, plague, filariasis, typhus typhus, trypanomiasis, leishmaniasis, and other vector-borne diseases have been caused by other causes. Many human diseases and deaths, from the early 17th to the early 20th century (Gubler). Vector-borne diseases account for about 17% of global parasitic diseases and infectious diseases. Only malaria causes more than 800,000 deaths each year, and 85% of these deaths are children under the age of five. There are about 50 million to about 100 million cases of dengue hemorrhage each year. An additional 250,000 to 500,000 cases of dengue hemorrhage (Matthews) occur each year. Vector control plays a very important role in the prevention and control of infectious diseases. However, insecticide resistance, including multiple insecticide resistance, is becoming more severe in all insect species of the main vector of human disease (Rivero et al.). Recently, more than 550 arthropod species have developed resistance to at least one pest (Whalon et al.). Furthermore, cases of insect resistance clearly continue to exceed the number of herbicide and fungicide resistant cases (Sparks et al.).

Every year, insects, plant pathogens and weeds destroy 40% of all potential food production. Despite the application of pesticides and the use of a wide range of non-chemical controls, such as crop rotation and biological control, this loss still exists. If only some of this food can be preserved, it can be used to feed more than three billion malnourished people (Pimental) in the world.

Plant parasitic nematodes are among the most widely distributed pests and are often one of the most insidious and costly pests. It is estimated that the losses caused by nematodes are about 9% in developed countries and about 15% in undeveloped countries. However, in the United States, according to a survey of various crops in 35 states, nematode-derived losses are as high as 25% (Nicol et al.).

It is worth noting that gastropods (scorpions and snails are less economically important than other arthropods or nematodes), but in some places, gastropods may substantially reduce yields substantially, seriously affecting the quality of harvested products, and It spreads human, animal and plant diseases. Although only a few dozen gastropods are serious regional pests, there are a few species that are important pests worldwide. In particular, gastropods affect a wide variety of agricultural and horticultural crops, such as cultivated land and pasture. And fiber crops; vegetables; shrubs and arbor fruits; herbaceous plants; and ornamental plants (Speiser).

Termites can cause damage to a variety of private and public buildings, as well as agricultural and forestry resources. It is estimated that in 2005, termites caused more than $50 billion in worldwide losses per year (Korb).

Therefore, for a number of reasons, including those mentioned above, there is a continuing need for expensive (estimated at approximately $256 million per pest in 2010), time consuming (average about 10 years per pest), and A novel insecticide developed by the difficulty (CropLife America). Certain references cited in this disclosure

CropLife America, The Cost of New Agrochemical Product Discovery, Development & Registration, and Research & Development predictions for the Future, 2010. Drewes, M., Tietjen, K., Sparks, TC, High–Throughput Screening in Agrochemical Research, Modern Methods In Crop Protection Research , Part I, Methods for the Design and Optimization of New Active Ingredients , Edited by Jeschke, P., Kramer, W., Schirmer, U., and Matthias W., p. 1–20, 2012. Gubler , D., Resurgent Vector–Borne Diseases as a Global Health Problem, Emerging Infectious Diseases, Vol. 4, No. 3, p. 442–450, 1998. Korb, J., Termites, Current Biology, Vol. 17, No 23, 2007. Matthews, G., Integrated Vector Management: Controlling Vectors of Malaria and Other Insect Vector Borne Diseases, Ch. 1, p. 1, 2011. Nicol, J., Turner S., Coyne, L., den Nijs, L., Hocksland, L., Tahna–Maafi, Z., Current Nematode Threats to World Agriculture, Genomic and Molecular Genetics of Plant – Nematode Interactions , p. 21–43, 2011. Pim Ental, D., Pest Control in World Agriculture, Agricultural Sciences – Vol. II, 2009. Rivero, A., Vezilier, J., Weill, M., Read, A., Gandon, S., Insect Control of Vector– Borne Diseases: When is Insect Resistance a Problem? Public Library of Science Pathogens, Vol. 6, No. 8, p. 1–9, 2010. Sparks TC, Nauen R., IRAC: Mode of action classification and insecticide resistance management, Pesticide Biochemistry and Physiology (2014) available online 4 December 2014. Speiser, B., Molluscicides, Encyclopedia of Pest Management , Ch. 219, p. 506–508, 2002. Whalon, M., Mota–Sanchez, D., Hollingworth , R., Analysis of Global Pesticide Resistance in Arthropods, Global Pesticide Resistance in Arthropods , Ch. 1, p. 5–33, 2008.

According to an embodiment of the present invention, a molecule having the following formula is specifically proposed Formula 1 ^{wherein: (A) R 1, R} 2, R 3, R 4, R 5, R 6, R 7, R 8, R 9, and R ¹⁰ are each independently selected from the Department of H, F, Cl, Br, I, CN, NO ₂ , OH, (C ₁ -C ₄ )alkyl, (C ₂ -C ₄ )alkenyl, (C ₁ -C ₄ )haloalkyl, (C ₁ -C ₄ ) alkane An oxy group, a (C ₁ -C ₄ )haloalkoxy group, and a (C ₃ -C ₆ )cycloalkyl group, wherein each alkyl group, alkenyl group, haloalkyl group, alkoxy group, haloalkoxy group, ring The alkyl group is optionally substituted with one or more substituents independently selected from the group consisting of H, F, Cl, Br, I, CN, NO ₂ , OH, (C ₁ -C ₄ )alkyl , (C ₂ -C ₄ )alkenyl, (C ₁ -C ₄ )haloalkyl, (C ₁ -C ₄ )alkoxy, (C ₁ -C ₄ )haloalkoxy, and (C ₃ - C ₆ ) cycloalkyl; (B) R ⁶ is H; (C) L is selected from the group consisting of (1) a bond linking nitrogen with a ring carbon, and (2) (C ₁ -C ₄ ) alkane a group wherein the alkyl group is optionally substituted with one or more substituents independently selected from the group consisting of F, Cl, CN, OH and pendant oxygen; (D) R ¹¹ is selected from the group consisting of Group consisting of: H, (C ₁ -C ₄ )alkyl, (C ₂ -C ₄ )alkenyl, (C ₂ -C ₄ ) alkenyloxy, (C ₂ -C ₄ )alkynyl, (C ₂ -C ₄ )alkynyloxy, (C ₁ -C ₄ )haloalkyl, (C ₁ -C ₄ )alkoxy (C ₁ -C ₄ )haloalkoxy, (C ₃ -C ₆ )cycloalkyl, (C ₃ -C ₆ )cycloalkoxy, (C ₃ -C ₆ )cycloalkenyl, (C ₃ -C ₆ ) cycloalkenyloxy, ((C ₁ -C ₄ )alkyl ((C ₃ -C ₆ )cycloalkyl), C(O)((C ₁ -C ₄ )alkyl), (( C ₁ -C ₄ )alkyl)C(O)((C ₁ -C ₄ )alkyl), ((C ₁ -C ₄ )alkyl)C(O)O((C ₁ -C ₄ ) And C(S)NH ₂ , wherein each alkyl, alkenyl, alkenyloxy, alkynyl, alkynyloxy, haloalkyl, alkoxy, haloalkoxy, cycloalkyl, naphthenic The oxy, cycloalkenyl, and cycloalkenyloxy groups are optionally substituted with one or more substituents independently selected from the group consisting of H, F, Cl, Br, I, CN, NO ₂ , OH And (2) R ¹² and R ¹³ are (G) or each independently selected from the group consisting of H, (C ₁ -C ₄ )alkyl, (C ₂ -C ₄ ) alkene , (C ₂ -C ₄ )alkynyl, (C ₁ -C ₄ )haloalkyl, ((C ₁ -C ₄ )alkyl((C ₃ -C ₆ )cycloalkyl), (C ₁ - C ₄₎ alkylphenyl, (C ₁ -C ₄₎ alkyl heterocyclyl, ((C ₁ -C ₄₎ alkyl) C (O) ((C 1 -C 4) Group), and ((C ₁ -C ₄₎ alkyl) C (O) O (( C 1 -C 4) alkyl), wherein each alkyl, alkenyl, alkynyl, haloalkyl, cycloalkyl The base, phenyl, and heterocyclic groups are optionally substituted with one or more substituents independently selected from the group consisting of F, Cl, CN, OH, and pendant oxygen; (F) R ¹⁴ , R ¹⁵ , R ¹⁶ , R ¹⁷ , and R ¹⁸ are each independently selected from the group consisting of H, F, Cl, Br, I, CN, NO ₂ , OH, (C ₁ - C ₄ )alkyl, (C ₂ -C ₄ )alkenyl, (C ₂ -C ₄ )alkynyl, (C ₁ -C ₄ )haloalkyl, (C ₁ -C ₄ )alkoxy, (C ₁ -C ₄ ) haloalkoxy, (C ₃ -C ₆ )cycloalkyl, (C ₃ -C ₆ )cycloalkoxy, phenyl, and (C ₁ -C ₄ )alkylphenyl, wherein Each alkyl, alkenyl, alkynyl, haloalkyl, alkoxy, haloalkoxy, cycloalkyl, cycloalkoxy, cycloalkenyl, and phenyl group is optionally one or more Substituted independently from the following substituents: F, Cl, Br, I, CN, NO ₂ and OH; (G) R ¹² and R ¹³ together with (NH)C ^x (N ^x ) form a 4 to 8-membered heterocyclic ring, wherein the heterocyclic ring may optionally be one Or more substituents independently selected from the R ¹⁹ group to be substituted with substituents, wherein R ¹⁹ is selected from from the group consisting of the following: H, F, Cl, Br , I, CN, OH, (C 1 -C ₄ ) alkyl, pendant oxygen, (C ₁ -C ₄ )alkyl, (C ₂ -C ₄ )alkenyl, (C ₂ -C ₄ )alkynyl, (C ₁ -C ₄ )haloalkyl, ( (C ₁ -C ₄ )alkyl ((C ₃ -C ₆ )cycloalkyl), (C ₁ -C ₄ )alkylphenyl, (C ₁ -C ₄ )alkylheterocyclyl, (C ₁ -C ₄ )alkyl)C(O)((C ₁ -C ₄ )alkyl), ((C ₁ -C ₄ )alkyl)C(O)O((C ₁ -C ₄ )alkyl , a phenyl group, and a heterocyclic group, wherein each alkyl, alkenyl, alkynyl, haloalkyl, cycloalkyl, phenyl, and heterocyclic group is optionally independently selected in one or more Substituted from the following group of substituents: F, Cl, Br, I, CN, OH and pendant oxygen; and the molecular N-oxide of formula 1, agriculturally acceptable acid addition salts , salt derivatives, solvates, crystalline polymorphs, isotopes, resolved stereoisomers, and tautomers.

Examples of the present disclosure is defined in the definition of these are not generally provided by a non-exhaustive and should not be construed as limiting the present disclosed. It will be understood that the substituents should be subject to the chemical bonding rules and stereo compatibility limitations associated with the particular molecule to which they are attached. These definitions are for the purposes of this disclosure only.

The term " active ingredient " means a material which has activity useful in controlling pests and/or which has activity for assisting other materials to better control pests, examples of which include, but are not limited to, killing Agent, algaecide, antifeedant, avicide, fungicide, bird repellent, chemical sterilization agent, fungicide, herbicide safener, herbicide, insect attractant, insect repellent, insecticide , mammalian agents, mating interferers, acaricides, nematicides, plant activators, plant growth regulators, rodenticides, synergists, and virucides (see alanwood.net). Specific examples of such materials include, but are not limited to, those listed in the active ingredient group a.

The term "active ingredient cluster group α" (hereinafter referred to as "AIGA") "collectively means based the following materials: (1) (3-ethoxypropyl) mercury bromide, 1,2-dibromoethane, 1 ,2-dichloroethane, 1,2-dichloropropane, 1,3-dichloropropene, 1-MCP, 1-methylcyclopropene, 1-naphthol, 2-(octylthio)ethanol, 2,3,3-TPA, 2,3,5-triiodobenzoic acid, 2,3,6-TBA, 2,4,5-T, 2,4,5-TB, 2,4,5-TP , 2,4-D, 2,4-DB, 2,4-DEB, 2,4-DEP, 2,4-DES, 2,4-DP, 2,4-MCPA, 2,4-MCPB, 2iP , 2-methoxyethyl mercury chloride, 2-phenylphenol, 3,4-DA, 3,4-DB, 3,4-DP, 3,6-dichloro 2-picolinic acid, 4-amine Pyridine, 4-CPA, 4-CPB, 4-CPP, 4-hydroxyphenethyl alcohol, 8-hydroxyquinoline sulfate, 8-phenylmercaptoquinoline, abamectin, A Abamectin-aminomethyl, abscisic acid, ACC, acephate, acequinocyl, acetamiprid, acethion, B Acetochlor, acetofenate, acetophos, acetoprole, acibenzolar, acifluorf En), alexifen, CAN, acrep, acrinthrin, acrolein, acrylonitrile, acypetacs, Afidol Afidopyropen, afoxolaner, alachlor, alanap, alanycarb, albendazole, aldicarb, dexamethasone , aldimorph, aldoxycarb, aldrin, allethrin, allicin, allidochlor, alosamide ), alloxydim, allyl alcohol, allyxycarb, arolac, alpha- cypermethrin, alpha- endosulfan, sub Alphamethrin, altretamine, aluminum phosphide, aluminum phosphide, ametoctradin, ametridione, ametryn ), ametryne, amiguzin, amicarbazone, amikathiazol, amidithion, sulfamethoxazole Flumet), amidosulfuron, aminocarb, aminocyclopyrachlor, aminopyralid, amine triazole, amiprofos-methyl, amine Amiprofos, amiprofos-methyl, amisulbrom, amiton, amitraz, amitrol, ammonium sulfonate, Amobam, amorphous silicone, amorphous cerium oxide, 1-aminopropyl phosphate (ampropylfos), AMS, anabasine, ancymidol, anilazine, sa Anilofos, anisuron, anthraquinone, antu, apholate, aramite, arprocarb, arsenic trioxide, arsenic (asomate) ), aspirin, asulam, athidathion, attraton, atrazine, aureofungin, ar Avermectin B1, AVG, avidycine, azaconazole, azadirachtin, azafenidi n), azamethiphos, azidithion, azimsulfuron, azinphosethyl, azinphos-ethyl, tamarind ( Azinphosmethyl), azinphos-methyl, aziprotryn, aziprotryne, azithiram, azobenzene, azocyclotin, azophos Azothoate), azoxystrobin, bachmedesh, barban, barbanate, barium hexafluoroantimonate, barium polysulfide, barium silicofluoride, pepper Barthrin, basic copper carbonate, basic copper chloride, basic copper sulfate, BCPC, beflubutamid , benalaxyl, bendal-M, benazolin, bencarbazone, benclothiaz, bendaqingbingzhi, exemption Bendiocarb), bendioxide, benefin, benfluralin, benfuracarb, benfuresate ), bensulfuron (benmihuangcaoan), wheat rust (benodanil), benomyl (benomyl), cumoxacor (benoxacor), benzene Benzofos, benquinox, bensulfuron, bensulide, bensultap, bentaluron, bentazon, bindarone Bentazone), benthiavalicarb, benthiazole, benthiocarb, bentranil, benzodox, alkyl dimethyl benzyl ammonium chloride , benzamril (benzamacril), benzamizole, benzamorf, hexachlorobenzene, benzfendizone, benzimine, benzipram , benzobicyclon, benzoepin, benzofenap, benzofluor, benzohydroxamic acid, benzomate, benzophosphoric acid Benzophosphate, benzothiadiazole, benzovindiflupyr, benzoximate, benzoylprop, benzthiazuron, oxaconazole (benzthiazuron) Benzuocaotong), benzyl benzoate, benzyladenine, berberine, beta- cyvern ( beta- cyfl) Uthrin), beta- cypermethrin, bethoxazin, BHC, bialaphos, bicyclopyrone, bifenazate, herbicide ether Bifenox), bifenthrin, bifujunzhi, bilanofos, binapacryl, bingqingxiao, bioallethrin, benzethrin Bioethanomethrin), biopermethrin, bioresmethrin, biphenyl, bisazir, bismerthiazol, bismerthiazol-copper, diphenyl Bismumermer methyl (i-naphthalene-y-sulphonate), bispyribac, bistrifluron, insecticidal double Bisultap), bitertanol, bithionol, bixafen, blasticidin-S, borax, Bordeaux mixture, boric acid, white Boscalid, BPPS, brassinolide, brassinolide-ethyl, brevisible pheromone (brevicomin), bromine Brodifacoum, brofenprox, brofenvalerate, broflanilide, brofluthrinate, bromacil, bromadiolone, dibromo Phosphorus (bromchlophos), bromethalin, bromethrin, bromfenvinfos, bromoacetamide, bromobonil, bromobutide ), bromociclen, bromocyclen, bromine-drip (DDT), bromofenoxim, bromophos, bromomethane, bromophos, ethyl - bromoxypin, bromopropylate, bromothalonil, bromoxynil, brompyrazon, bromuconazole, bronopol, BRP, BTH , bucarpolate, bufencarb, buminafos, bupirimate, buprofezin, Burgundy mixture, busulfan ( Busulfan), busulphan, butacarb, butachlor, butafenacil, forage (butam), butamifos, butane-fipronil, butathiofos, butenachlor, butane-fipronil, Butethrin, buthidazole, buthiobate, buthiuron, butifos, butocarboxim, butonate, and mosquitoes Ketone (butopyronoxyl), butoxycarboxim, butralin, butroxydim, buturon, butylamine, butyrate, butyrate Butylchlorophos), butylene-fipronil, cacodylic acid, cadusafos, cafenstrole, calciferol, calcium arsenate, Calcium chlorate, calcium cyanamide, calcium cyanide, calcium polysulfide, calvinphos, cambendichlor, camphechlor, camphor, tetrachlordane (captafol), captan, (carbam), carbamorph, carbanolate, carbaril, carbaryl, weeding Carbosulam, carbathion, carbendazim, carbendazol, carbetamide, carbofenotion, carbofuran, carbon disulfide, Carbon tetrachloride, carbonyl sulfide, carbophenothion, carbophos, carbosulfan, carboxazole, carboxide , carboxin, carfentrazone, carpropamid, cartap, carvacrol, carvone, CAVP, CDAA, CDEA, CDEC, Cellocidin, CEPC, ceralure, cerenox, cevadilla, Cheshunt mixture, chinalphos, Aikas - Methyl (chinalphos-méthyl), chinomethionat, chinomethionate, chiralaxyl, chitosan, chlobenthiazone, chlomethoxyfen ), chloralose, chloramben, chloramine phosphorus, chloramphenicol Henicol), chloraniformethan, chloranil, chloranocryl, chlorantraniliprole, chlorazifop, chlorazine, chlorbenside ), chlorbenzuron, chlorbicyclen, chlorbromuron, chlorbufam, chlordane, chlordecone, chlordimeform , chlorempenthrin, chloretazate, chlorethephon, chlorethoxyfos, chloreturon, chlorfenac, chlorfenapyr , 2-(2-chlorophenyl)-1H-chlorfenazole, chlorfenethol, chlorfenidim, chlorfenprop, chlorfenson, diazepam (chlorfensulphide), chlorfenvinphos, chlorfenvinphos-methyl, chlorfluazuron, chlorflurazole, chlorflurecol, chlorofluren , chloroflurenol, chloridazon, chlorsulfuron Chlorimuron, chlorinate, chlor-IPC, chlormephos, chlormequat, chlormesulone, chlormethoxynil , chlornidine, chlornitrofen, chloroacetic acid, chlorobenzilate, chlorodinitronaphthalene, chlorofénizon, chloroform, chloromebuform ), chloromethiuron, chloroneb, chlorophacinone, chlorophos, chloropicrin, chloropon, right-handed Chloroprallethrin, chloropropylate, chlorothalonil, chlorotoluron, (chloroxifenidim), chloroxuron, chloroxynil , chlorphonium, chlorphoxim, chlorprazophos, chlorprocarb, chlorpropham, chlorpyrifos, chlorpyrifos-methyl Tetrachloroquine Chlorquinox, chlorsulfuron, chlorthal, chlorthiamid, chlorthiophos, chlortoluron, chlozolinate, chltosan , cholecalciferol, choline chloride, chromafenozide, cicloheximide, cimectacarb, cimetacarb, cinerin I, Guamethrin II, cinerins, cinidon-ethyl, cinmethylin, cinosulfuron, cintofen, benzalkonium Ciobutide, cisanilide, cismethrin, clacyfos, clefoxydim, clenpirin, clenprolin (clenpyrin), clethodim, climbbazole, cloodinate, clodinafop, cloethocarb, clofencet, clofenotane , clofentezine, clofenvinfos, clofibric acid, clofop, clomazone ), clomeprop, clonitralid, cloprop, cloproxydim, clopyralid, cloquintocet, chlorsulfuron Amine (cloransulam), closantel, clothianidin, clatumrimazole, cloxyfonac, cloxylacon, clozylacon, CMA , CMMP, CMP, CMU, dodecadienol (codlelure), colecalciferol, colophonate, copper 8-quinolinolate, copper acetate, acetamidine Copper arsenite, copper arsenate, copper carbonate, basic, copper hydroxide, copper naphthalate, copper oleate, copper oxychloride, copper ruthenate, copper sulfate, copper sulfate, basic, copper zinc chromate, chlorine Coumachlor, coumafène, coumafos, coumafuryl, coumaphos, coumatetralyl, coumethoxystrobin, Coumithoate, coumoxystrobin, CPMC, CPMF, CPPC, cedazine, cresol, cresylic ac Id), methylcrimidine, crotamiton, crotoxyfos, crotoxyphos, crufomate, cryolite, fly ketone (cue-lure), cufraneb, cumyleron, cumyluron, cuprobam, cuprous oxide, curcumenol, CVMP, cyanamide, cyanide Cyanatryn, cyanazine, cyanofenphos, cyanide, cyanophos, cyanthoate, cyantraniliprole, cyanuric acid, racer (cyazofamid), cybutryne, cyclafuramid, cyclanilide, cyclaniliprole, cyclethrin, cycloate, Cycloheximide, cycloprate, cycloprothrin, cyclopyrimorate, cyclosulfamuron, cyclooxydim, cyclocyclon ), cyenopyrafen, cyflufenamid, cyflumetofen, cyfluthrin, chlorofluorocyanate Cyhalodiamide, cyhalofop, cyhalothrin, cyhexatin, cymiazole, cymoxanil, cyometrinil, vodidine (cypendazole), cypermethrin, cyperquat, cyphenothrin, cyprazine, cyprazole, cyproconazole, cypro (cyprodinil), cyprofuram, cypromid, cyprosulfamide, cyromazine, cythioate, cytrex, ticks Long (daimuron), and pulled the present (dalapon), butoxy acyl hydrazine (daminozide), juvenile pyridazin ketone (dayoutong), Myron (dazomet), DBCP, d - camphor (d -camphor), DCB, DCIP , DCPA ( Japan ), DCPA (USA), DCPTA, DCU, DDD, DDPP, DDT, DDVP, debacarb, decafentin, decamethrin, decarbofuran , deetamine, dehydroacetic acid, deiquat, delachlor, delnav, deltamethrin, demephion Methyl chlorpyrifos-O, methyl chlorpyrifos-S, demeton, methyl endogenous phosphorus, endogenous phosphorus-O, methyl endophos-O, endogenous phosphorus-S, A Phosphorus-S, demeton-S-methyl sulphon, demeton-S-methylsulphon, DEP, depalléthrine, derris, beet desmedipham), diuron net (desmetryn), diuron net (desmetryne), d - trans-prallethrin (d -fanshiluquebingjuzhi), eliminating Fenlong (diafenthiuron), chloro phosphoramidite (dialifor), to give Larsson ( Dialifos), diallate, di-allate, diamidafos, dianat, diatomaceous earth, diatomite, diazinon , dibrom, dibutyl phthalate, dibutyl succinate, dicamba, dicapthon, dichlobenil, deichlofenthion, Dichlofluanid, dichlonone, dichloralurea, dichlorbenzuron, dichlorfenidim, dichlorflurecol, dichlorflureno l), dichlormate, dichlormid, dichloromethane, dichlorophen, 2,4-dipropionic acid, 2,4-dipropionic acid-P, Dichlorvos, dichlozolin, dichlozoline, diclobutrazol, diclocymet, diclofop, chlorpyrifos Diclomezine), dicloran, dicloromezotiaz, diclosulam, difofo, dicophane, dicoumarin Dicoumarol, dicresyl, dicrotophos, dicryl, dimumarin, dicyclanil, dicyclonon, dite Ld (dieldrin), dienochlor, diethamquat, diethatyl, diethion, diéthion, diethofencarb, di Dietholate, (diéthon), diethyl pyrocarbonate, diethyltoluamide, difenacoum, difenoconazole, pentylene Difenopenten, difenoxuron, difenzoquat, difethialone, flubenquinone (diflovidazin), diflubenzuron, diflufenican, diflufenicanil, diflufenzopyr, diflumetorim, dikegulac, two Dilor, dimatif, dimefluthrin, dimefox, Dimefuron, dimehypo, dimepiperate, dimetachlone, dimetan, dimethacarb, dimethachlone, dimethine Dimethachlor, dimethametryn, dimethenamid, chlorpyrifos-P, dimethipin, dimethirimol, dimethoate, up to Dimethomorph, dimethrin, dimethyl carbate, dithiodimethane, dimethyl decanoate, dimethylvinphos, dimetilan ), dimexano, dimidazon, dimoxystrobin, dimpylate, dimuron, dinex, pyridine oxazole Dingjunezuo), diniconazole, Dakli-M, dinitramine, dinitrophenol, dinobuton, dinocap, white powder gram-4, white powder gram-6, enemy Dinocton, dinofenate, dinopenton, dinoprop, dinosam, dinoseb, nitrenate acaricide (d Inosulfon), dinotefuran, dinoterb, dinoterbon, diofenolan, dioxabenzofos, dioxacarb, dioxathion ), dioxation, diphacin, diphacinone, diphenadione, diphenamid, diphenamide, diphenyl hydrazine, diphenylamine, Diphenylsulphide, diprogulic acid, dipropalin, dipropetryn, dipterex, dipymetitrone, dithiopyridinium (dipyrithione), diquat, disodium tetraborate, disosultap, disparlure, disugran, disul, disulfide Disulfiram), disulfoton, ditalimfos, dithianon, dithicrofos, disulfide, dithiométon, dithiopyr, Diuron, dixanthogen, d-limonene, DMDS, DMPA, DNOC, Twelve Rings Dodemorph, dodicin, dodine, dofenapyn, doguadine, dominicalure, doramectin, DPC , drazoxolon, DSMA, d-trans-allethrin, d-trans-resmethrin, dufulin, Dymron, EBEP, EBP, ebufos, ecdysterone, echlomezol, EDB, EDC, EDDP, edifenphos, eglinazine , emamectin, EMPC, empenthrin, enadenine, endosulfan, endothal, endothall, endophos ), endrin, enestroburin, enilconazole, enoxastrobin, ephirsulfonate, EPN, propionene lactone (epocholeone) ), epofenonane, epoxiconazole, eprinomectin, epronaz, epsilon-metofluthrin, ε-oxybenzyl Fluor (epsilon-momfluorothrin), EPTC, erbon, ergocalciferol, erlujixiancaoan, esdépalléthrine, esfenvalerate, ESP , esprocarb, etacelasil, etaconazole, etaphos, etem, ethaboxam, ethachlor, B Ethalfluralin, ethametsulfuron, ethaprochlor, ethephon, ethidimuron, ethiofencarb, ethiolate, Ethion, ethiozin, ethiprole, ethirimol, ethoate-methyl, ethobenzanid, yibend ( Ethofumesate), ethohexadiol, ethoprop, ethoprophos, ethoxyfen, ethoxyquin, ethoxysulfuron, Ethylchlozate, ethyl formate, ethyl pyrophosphate, ethylan , ethyl-DDD, ethylene, ethylene dibromide, ethylene dichloride, ethylene oxide, ethylicin, ethyl mercury 2, 3-dihydroxypropyl thiol ester (ethylmercury 2, 3-dihydroxypropyl Mercapride), ethylmercury acetate, ethylmercury bromide, ethyl mercuric chloride, ethyl mercury phosphate, etinofen, ETM, etnipromid, Etobenzanid, etofenprox, etoxazole, etridiazole, etrimfos, étrimphos, eugenol, EXD, famoxadone, famphur, fenac, fenamidone, fenaminosulf, fenaminstrobin, fenamiphos ), fenapanil, fenarimol, fenasulam, fenazaflor, fenazaquin, fenbuconazole, fenbutatin Oxide), fenchlorazole, fenchlorphos, fenchlorfos, fenclorim, fenethacar b), fenfluthrin, fenfuram, fenhexamid, fenidin, fenitropan, fenitrothion, fentanyl Ester (fénizon), fenjuntong, fenobucarb, fenolovo, 2,4,5-propionic acid (fenoprop), fenothiocarb (fenothiocarb), fenthene Nine (fenoxacrim), fenoxanil, fenoxaprop, fennelin-P, fenoxasulfone, fenoxycarb, fenpiclonil, pyrethrin ( Fenpirithrin), fenpropathrin, fenpropidin, fenpropimorph, fenpyrazamine, fenpyroximate, fenquinotrione, cockroach Fenridazon, fenson, fensulfothion, fenteracol, fenthiaprop, fenthion, fenthion-ethyl ), fentiaprop, fentin, fentrazamide, fentrifanil, fenuron, non Long TCA, fenvalerate, ferbam, ferimzone, ferrous sulfate, fipronil, flamprop, wheat fluoroester-M, volts Flazasulfuron, flocoumafen, flometoquin, flonicamid, florasulam, fluacrypyrim, dextrorotatory chloropropyne Fluezaindolizine, fluazifop, fluazifop-P, fluazinam, fluazolate, fluzuron, fluoride Flubendiamide, flubenzimine, flubrocythrinate, flucarbazone, flucetosulfuron, fluchloralin, flucofuron , flucycloxuron, flucythrinate, fludioxonil, fluénéthyl, fluenetil, fluensulfone, flufenacet ), flufenerim, flufenican, flufenoxuron, flufenoxystrobin, trifluoro Permethrin (flufenprox), fluoropyridazine Flufenpyr, flufenzine, flufiprole, fluhexafon, flumethrin, flumetover, flumetalin ), flumetsulam, flumezin, flumiclorac, flumioxazin, flumipropyn, fluoride Flumorph, fluometuron, fluopicolide, fluopyram, fluorbenside, fluoridamid, fluoroacetamide, Fluoroacetic acid, fluorochloridone, fluorodifen, fluoroglycofen, fluoroimide, fluoromide, Fluoromidine, fluoronitrofen, fluoroxypyr, fluothiuron, fluotrimazole, fluoxastrobin, fluoxazole (flupoxam), flupropacil, flupropadine, flupropanate, flupyradifurone, flupyrsulfuron, fluoroquinazole (fluquinconazole), fluralaner, flurazole, flurecol, flurenol, fluridone, flurochloridone, chlorofluorocarbon Fluromidine, fluroxypyr, flurprimidol, flufenamide (flu) Rsulamid), flurtamone, flusilazole, flusulfamide, flutenzine, fluthiacet, fluthiamide, fluphene (flutianil), flutolanil, flutriafol, fluvalinate, fluxametamide, fluxapyroxad, fluxofenim, Stempel, folfet, fomesafen, fonofos, foramsulfuron, forchlorfenuron, formaldehyde, formetanate , formothion, formparanate, fosamine, fosetyl, fosmethilan, fospirate, fosthiazate ), fosthietan, frontalin, fthalide, fuberidazole, fucaojing, fucaomi, flufenicol (fujunmanzhi), fulumi, fumarin, funaihecaoling, fuphenthiourea, ethylene Furalane, furalaxyl, furamethrin, furametpyr, furan tebufenozide, furathiocarb, xyfuramide (furcarbanil), furconazole, furconazole-cis, furethrin, furfural, furilazole, furmecyclox, furfuryl Furophanate, furyloxyfen, γ-BHC, gamma- cyhalothrin, γ-HCH, genit, gibberellic acid, red A3 (gibberellin A3), gibberellins, gliftor, glitor, glucochloralose, glufosinate, glufosinate-P, solid Glyondin, glyoxime, glyphosate, glyphosine, gossyplure, grandlure, griseofulvin Griseofulvin), guanoctine, guazatine, halacrinate, haloxifen, halfenprox, Halofenozide, halosafen, halosulfuron, haloxydine, haloxyfop, chlorofluoro-P, chlorofluoro-R, HCA, HCB, HCH, hemel, hempa, HEOD, heptachlor, heptafluthrin, heptenophos, heptopargil, avermectin Herbimycin), herbimycin A, heterophos, hexachlor, hexachloran, hexachloroacetone, hexachlorobenzene, hexachlorobutane Ethene, hexachlorophene, hexaconazole, hexaflumuron, hexafluoramin, hexaflurate, hexalure, hexamide , hexazinone, hexylthiofos, hexythiazox, HHDN, holosulf, homobrassinolide, huancaiwo, sulfonate Net (huanchongjing), huangcaoling, hyunjunzuo, hydramethylnon, hydrargaphen, slaked lime Hydred lime), hydrogen cyanamide, hydrogen cyanide, hydroprene, hydroxyisoxazole, hymexazol, hyquincarb, IAA , IBA, IBP, icaridin, imazalil, imazamethabenz, imazamox, imazapic, imazapyr, Imazaquin, imametapyryr, imazosulfuron, imibenconazole, imikilinos, imidacloprid, imidaclothiz , iminoctadine, imiprothrin, inabenfide, indanofan, indaziflam, indoxacarb, inezin , infusorial earth, iodobonil, iodocarb, iodofenphos, iodomethane, iodosulfuron, iofensulfuron, Ioxybenil, ipazine, IPC, ipconazole, ipfencarbazone, C Iprobenfos, iprodione, iprovalicarb, iprymidam, ipsdienol, ipsenol, IPSP, IPX, yi Isofidofos, isazofos, isobenzan, isocarbamid, isocarbamide, isocarbophos, isocil, Isochloropurine (isodrin), isofenphos, methyl sulfasin, isofetamid, isolam, iso Isomethiozin, isororuron, isopamphos, isopolinate, isoprocarb, isoprocil, isopropalin, Isopropazol (isopropazol), isoprothiolane, isoproturon, isopyrazam, isopyrimol, isothioate, isotianil ( Isotianil), isouron, isovaledione, different Isoxaben, different Isoxachlortole, isoxadifen, different Isooxaflutole, different Isoxapyrifop, isoxathion, isuron, ivermectin, different Ixoxaben, izopamfos, izopamphos, japonilure, japothrins, jasmolin I, methocyanin II , jasmonic acid, jiahuangchongzong, jiajizengxiaolin, jiaxiangjunzhi, jiecaowan, jiecaoxi, jinggangmycin A (Jinganmycin A), retaining loose particles (jodfenphos), juvenile hormone I (juvenile hormone I), juvenile hormone II, juvenile hormone III, thiophene ah permethrin (kadethrin), κ- Bifen Ning (kappa -bifenthrin), κ- elimination Kappa- tefluthrin, karbutilate, karetazan, kasugamycin, kejunlin, kelevan, ketospiradox, Kieselguhr, kinetin, kinoprene, kiralaxyl, kresoxim-methyl, kuicaoxi, flucene Lactofen, lambda-cyhalothrin, latilure, lead arsenate, lenacil, lieutenant Lepimectin, leptophos, linbenjingzhi, lime sulfur, lindane, lineatin, linuron, force pine (lirimfos), litlure, looplure, lufenuron, chlorofluorocyanamide, lüxiancaolin, lüxiancaolin, lvdingjunzhi , flufenthrin (lvfumijvzhi), lvxiancaolin, lythidathion, M-74, M-81, MAA, magnesium phosphide, marathion, maldison, cis Maleic hydrazide, malonoben, maltodextrin, MAMA, mancopper, mancozeb, mandestrobin, Mandipropamid, maneb, matrine, mazidox, MCC, MCP, MCPA, thioethyl MCPA, MCPB, MCPP, mebenil, Mecarbam, mecarbinzid, mecarphon, mecoprop, 2-methyl-4-chloropropionic acid-P, acaricidal Medimeform), Medinoterb, medlure, mefenacet, mefenoxam, mefenpyr, mefluidide, tetradecadienoic acid (megatomoic acid), beeswaxol, melitoxin, MEMC, menazon, MEP, mepanipyrim, meperfluthrin, mephenate , mephosfolan, mepiquat, mepronil, meptyldinocap, mercaptodimethur, mercaptophos, mercaptophos thiol, horse Mercaptothion, mercuric chloride, oxidized mercury, mercurous chloride, merphos, merphos oxide, mesoprazine, mesosulfuron, sulphur Mesotrione, mesulfen, mesulfenfos, mesulphen, metacresol, metaflumizone, metalaxyl, Right metalaxyl-M, metaldehyde, metam, Zolamapamine, benzene Metaamitron, metaphos, metaxon, metazachlor, metazosulfuron, metazoxolon, thiophene (metconazole), metepa, metflurazon, methabenzthiazuron, metacrifos, methalpropalin, weibaimu ( Metham), methamidophos, methasulfocarb, methazole, methfuroxam, methimenzuron, methidathion, methotrexate (methiobencarb), methiocarb, methiopyrisulfuron, methiotepa, methiozolin, methiuron, methocrotophos , métholcarb, metometon, methomyl, metoprene, mesoprotryn, methoprotryne, quinolinecarboxylic acid-butyl ( Methoquin-butyl), metothrin, methoxychlor, methoxyfenozide, Methoxyphenone, methyl apholate, methyl bromide, methyl eugenol, methyl iodide, methyl isothiocyanate, methyl baba Methyl parathion, methylacetophos, methyl chloroform, methyldithiocarbamic acid, methyldymron, methylene chloride, methyl fenfensone (methyl- Isofenphos), methylmercaptophos, methylmercaptophos oxide, methylmercaptophos thiol, methylmercury benzoate, methylmercury benzoate (methylmercury dicyandiamide), methylmercury pentachlorophenoxide, methylneodecanamide, methylnitrophos, methyltriazothion, metiuzolin Meirm, free of metiram-zinc, metobenzuron, metobromuron, metofluthrin, metolachlor, metolcarb Tribenuron (metometuron), metominostrobin (metominostrobin), metosulam (metosulam), Metoxadiazone, metoxuron, metrafenone, metriam, metribuzin, metrifonate, metriphonate, thiabium Amine (metsulfovax), metsulfuron, mevinphos, mexacarbate, miechuwei, mieshuan, miewenjuzhi, milbemectin ), milbemycin oxime, milneb, mimanan, mipafox, MIPC, mirex, MNAF, moguchun, rice Molten, molosultap, momfluorothrin, monalide, monisuron, monoamitraz, monochloroacetic acid, arsenic Monocrotophos, monolinuron, monomehypo, monosulfiram, monosulfuron, monosultap, monuron, herbicide TCA, morfamquat, moroxydine, morphothion, morzid, moxidectin, MPMC, MSMA MTMC, muscalure, myclobutanil, myclozolin, myricyl alcohol, N-(ethylmercury)-p-toluenesulfonamide, NAA, NAAm, Nabam, naftalofos, naled, naphthalene, naphthylamine, naphthalic anhydride, naphthalophos, naphthyloxyacetic acid, naphthaleneacetic acid , naphthylindane-1,3-diones, naphthyloxyacetic acids, naproanilide, napropamide, napropamide -M), naptalam, natamycin, NBPOS, neburea, neburon, nendrin, neonicotinoid, nikonfos ), niclofen, niclosamide, nicofifen, nicosulfuron, nicotine, nicotine sulfate, nifluridide, nick Nikkomycins, NIP, nipyraclofen, nipyralofen, nitenpyram, nithiazine, killing Nitralin, nitrapyrin, nitrilacarb, nitrofen, nitrofluorfen, nitrostyrene, nitrothal-isopropyl, mouse Nobormide, sterol, norbormide, norea, norflurazon, nornicotine, noruron, novaluron , polyfluuron (noviflumuron), NPA, nuarimol, nuranone, OCH, octachlorodipropyl ether, octhiminone, o-dichlorobenzene, fur Ofurace, omethoate, o-phenylphenol, orbencarb, orfralure, orthobencarb, ortho-dichlorobenzene, Orthosulfamuron, oryctalure, oressastrobin, oryzalin, osthol, osthole, ostramone ), ovatron, ovex, oxabetrinil, propyne Oxadiargyl, oxadiazon, oxadixyl, oxamate, oxamyl, oxapyrazon, oxapyrazone, ring Oxalsulfuron, oxathiapiprolin, Oxaziclomefone, oxine-copper, oxine-Cu, oxolinic acid, Oxpoconazole, oxycarboxin, oxydemeton-methyl, oxydeprofos, oxydisulfoton, oxyenadenine, oxyfluorfen, oxidation Oxymatrine, oxytetracycline, oxythioquinox, PAC, paclobutrazol, paichongding, palléthrine, PAP, p-dichlorobenzene (para-dichlorobenzene), parafluron, paraquat, parathion, methylbalazon, parinol, Paris green, PCNB, PCP , PCP-Na, p-dichlorobenzene, PDJ, pebulate, pédinex, pefurazoate, pelargonic acid, pingke ( Penconazole), pencycuron, pendimethalin, penfenate, penflufen, penfluron, penoxalin, flat rot Penoxsulam), pentachlorophenol, pentachlorophenyl laurat, chlorpyrifos (pe) Ntanochlor), penthiopyrad, pentmethrin, cyclopentane Pentoxazone, perchlordecone, perfluidone, permethrin, pethoxamid, PHC, phenamacril, ethyl cyanobacteria Amine (phenamacril-ethyl), phénaminosulfate, phenazine oxide, phénétacarbe, phenisopham, phenkapton, phenmedipham, Ethyl beetine, phenobenzuron, phenothiol, phenothrin, phenproxide, phenthoate, phenylmercuriurea, benzene Phenylmercury acetate, phenylmercury chloride, phenylmercury derivative of pyrocatechol, phenylmercury nitrate, phenylmercury salicylate (phenylmercury salicylate), phorate, phosacetim, phosalone, phosametine, phosazetim, phosazetin, triphosphorus ( Phoscyclotin), phosdiphen, phosphos l), phosfolan, phosfolan-methyl, phosglycin, phosmet, phosnichlor, phosphamide ), phosphamidon, phosphine, phosphinothricin, phosphocarb, phosphorus, phostin, phoxim, methyl basalson, ferrets Phthalide), phthalophos, phthalthrin, picarbutrazox, picaridin, picloram, picolinafen, pyridine Picoxystrobin, pimaricin, pindone, pinoxaden, piperalin, piperazine (piperazine), piperonyl butoxide, piperonyl cyclonene, piperophos, piproctanly, piproctanyl, piprotal, piprotal Pirametaphos, pirimicarb, piriminil, pirimioxyphos, pirimiphos-ethyl, pirimiphos-methyl, murmurone (pival) ), pivaldione, plifenate, PMA, PMP, polybutenes, polycarbamate, polychlorcamphene, polyethylidene Polyethoxyquinoline, polyoxin D, polyoxins, polyoxorim, polythialan, potassium arsenite , potassium azide, potassium cyanate, potassium ethyl xanthate, potassium naphthenate, potassium polysulfide, potassium thiocyanate , 4,4-DDT (pp '-DDT), Puyaliening (prallethrin), Precocene I (precocene I),熟素 II, presenilin III, pretilachlor, primidophos, primisulfuron, probenazole, prochloraz, proclonol, propionitrile Procyazine, procymidone, prodiamine, profenofos, profluazol, profluralin, profluthrin, chlorine Profoxydim, (profurite-aminium), proglinazine, prohexadione, prohydrojasmon, promacyl, promecarb, extinguish Prometon, prometryn, prometryne, promurit, pronamide, propachlor, propafos, propazone (propamidine), propamocarb, propanil, propaphos, propaquizafop, propargite, proparthrin, propazine , propetamphos, propham, propiconazole, propidine, a Propineb, propisochlor, propoxur, propoxycarbazone, propyl isome, Propyrisulfuron, propyzamide, proquinazid, prosuler, prosulfalin, prosulfocarb, trifluoropropane Prosulfuron, prothidathion, prothiocarb, prothioconazole, prothiofos, prothoate, protrifenbute, Proxan, prymidophos, prynachlor, psoralen, psoralene, pydanon, flubenazole hydroxylamine (pydiflumetofen), pyflubumide, pymetrozine, pyracarbolid, pyraclofos, pyraclonil, pyraclostrobin, pyraflufen ), pyrafluprole, pyramat, pyrametostrobin, pyraoxystrobin, pyrasulfyrazole, pyrazilflumid, pyrazolate , pyrazolynate, pyrazon, pyrazophos, baisulong (p Yrazosulfuron), pyrazothion, pyrazoxyfen, pyresmethrin, pyrethrin I, pyrethrin II, pyrethrin, grass ether-isopropyl (pyribambenz -isopropyl),pyribambenz-propyl,pyribencarb,pyribenzoxim,pyributicarb,pyriclor,pyridaben ), pyridafol, pyridalyl, pyridaphenthion, pyridaphenthione, pyridate, pyridinitril, bifenofol ( Pyrifenox), pyrifluquinazon, pyrifalid, pyrimétaphos, pyrimethanil, pyrimicar, pyrimidifen, pyrimethazine Pyrimanobac, pyrimiminostrobin, pyrimiphos-éthyl, pyrimiphos-méthyl, pyrimisulfan, pyrimimate, rodenticide (pyrinuron), pyrifenone, pyriprole, pyripolol, pyrip Roxyfen), pyrisoxazole, pyrithiobac, pyrolan, pyroquilon, pyroxasulfone, pyroxulam, chlorine Pyroxychlor, pyroxyfur, qincaosuan, qingkuling, quassia, quinacetol, quinalphos, methyl Yusong, quinazamid, quinclorac, quinconazole, quinmerac, quinoclamine, quinomethionate, chloramphenicol (quinonamid), quinothion, quinoxyfen, quintiofos, quintozene, quizalofop, sorghum-P, mosquito repellent (quwenzhi) ), Quyingding, Rabenzazole, Rafoxanide, R-diniconazole, Rebemide, Reglone, Resveratrol (renriduron), rescalure, resmethrin, rhodetanil, rhodopaponin-III, virus (ribavirin), rimsulfuron, rizazole, R-metalaxyl, rodentanamine, ronnel, rotenone, blue Ryania, sabadilla, saflufenacil, saijunmao, saisentong, salicylamine, salifluofen, blood root Alkali (sanguinarine), santonin, S-bioallethrin, schradan, scilliroside, sebuthylazine, secbumeton , sedaxane, selamectin, semiamitraz, sesamex, sesamolin, sesone, sethoxydim, west Sevin, shuangjiaancaolin, shuangjianancaolin, S-hydroprene, siduron, sifumijvzhi , siglure, silafluofen, silatrane, silica aerogel, silicone, silthiofam ), silthiopham, silthiophan, 2,4,5-propionic acid (silvex), simazine, simeconazole, simeton ), simetryn, simetryne, sintofen, S-kinoprene, slaked lime, SMA, S-Missing (S -methoprene), S-metolachlor, sodium arsenite, sodium azide, sodium chlorate, sodium cyanide, sodium fluoride, sodium fluoroacetate, sodium hexafluoroantimonate, sodium naphthenate (sodium naphthenate), sodium o-phenylphenoxide, sodium orthophenylphenoxide, sodium pentachlorophenate, sodium pentachlorophenoxide, sodium polysulfide (sodium polysulfide), sodium silicofluoride, sodium tetrathiocarbonate, sodium thiocyanate, solan, sophamide, spinetoram, Spinosad, spirodiclofen, spiromesifen, spirotetramat, spiroxamine Stirofos, streptomycin, strychnine, sulcatol, sulcofuron, sulcotrione, sulfallate ), sulfentrazone, sulfiram, sulfluramid, sulfodiazole, sulfometuron, sulfosate, sulfonamide (sulfosulfuron), sulfotep, sulfotepp, sulfoxaflor, sulfoxide, sulfoxime, sulfur, sulfuric acid, sulfonium fluoride, sulphon Sulkglycapin, sulphosate, sulprofos, sultropen, swep, tau- fluvalinate, tavron , tizimcarb, TBTO, TBZ, TCA, TCBA, TCMTB, TCNB, TDE, tebuconazole, tebufenozide, tebufenpyrad, isobutyl quinolate (tebufloquin) ), tebupirimfos, tebutam, tebuthiuron, tecloftalam, tecnazene, blessing Double (tecoram), dicion, teflubenzuron, tefluthrin, tefuryltrione, tembotrione, tefefos , temephos, tepa, TEPP, tepraloxydim, teproloxydim, terallethrin, terbacil, special grass Terbucarb, terbuchlor, terbufos, terbumeton, terbuthylazine, terbutol, terbutryn, terding (terbutryne), terraclor, terramicin, terramycin, tetcyclacis, tetrachloroethane, tetrachlorvinphos, four Tetraconazole, tetradifon, tetradisul, tetrafluron, tetramethrin, tetramethylfluthrin, tetraamine, chlorpyrifos ( Tetranactin), tetraniliprole, tetrapion, tetrasul, thallium sulfate , thallous sulfate, thenylchlor, cypermethrin, thiabendazole, thiacloprid, thiazepine (thiadiazine), thiadifluor, thiamethoxam, thiameturon, thiapronil, thiazafluron, thiazfluron, thiazone, Thiazopyr, thicrofos, thicyofen, thidiazimin, thidiazuron, thiencarbazone, thifensulfuron ( Thifensulfuron), thifluzamide, thimerosal, thimet, thiobencarb, thiocarboxime, thiochlorfenphim, sulphur Thiochlorphenphime, thiocyanatodinitrobenzenes, thiocyclam, thiodan, thiodiazole-copper, thiodicarb, long-lasting effect Thiofanocarb, thiofanox, thiofluoximate, thiohempa, thiomersal, thiometon, thionazin, multi-protective Thiophanate), thiophanate-ethyl, thiophanate-methyl, pair Thiophos, thioquinox, thiosemicarbazide, thiosultap, thiotepa, thioxamyl, thiram, thiram (thiuram), thuringiensin, tiabendazole, tiadinil, tiafenacil, tiaojiean, TIBA, thiatol ), tiocarbazil, tioclorim, tioxazafen, tioxymid, tirpate, TMTD, tolclofos-methyl, detached Tolfenpyrad, tolprocarb, tolpyralate, tolyfluanid, tolylfluanid, tolyl acetic acid, tomarin , topramezone, toxaphene, tPN, tralkoxydim, tralocythrin, tralmethrin, tramopyril, bewunning (transfluthrin), transpermethrin, tretamine, triacontanol, triadimef On), triadimenol, triafamone, triallate, tri-allate, triamiphos, triapenthenol, three Triarathene, triarimol, triasulfuron, triazamate, triazbutil, three Triaziflam, triazophos, triazothion, azathionas (triazoxide), tribasic copper chloride, tribasic copper sulfate, tribenuron, tribufos, tributyltin oxide, tricamba, Tricholamide, trichlopyr, trichlorfon, trichlormetaphos-3, trichloronat, trichloronate, triclosan Trichlorotrinitrobenzenes, trichlorphon, triclopyr, triclopyricarb, tricresol, tricyclazole, tricyclohexyltin hydroxide (trichlorotrinitrobenzenes), trichlorphon (trichlorophon), triclopyricarb (triclopyricarb), tricresol (triresol), tricyclazole (tricyclazole) Tricyclohexyltin hydroxide), tridemorph, tridiphane, trietazine, trifenmorph, trifenofos, trifloxystrobin, trifluoro Trifloxysulfuron, trifludimoxazin, triflumezopyrim, triflumizole, triflumuron, trifluralin, fluamine Triflusulfuron, trifop, Fluoro grass oxime (trifopsime), Sai Funing (triforine), trihydroxytriphenylmethane , trimedlure, trimethacarb, trimeturon, trinexapac, triphenyltin, triprene, tripropindan , triptolide, tritac, trithialan, triticonazole, tritosulfuron, trunc-call, defoliation (tuoyelin), uniconazole, uniconazole-P, urbacide, uredepa, valerate, validamycin, Validamycin A, valifenalate, valone, vamidothion, vangard, vaniliprole, vernolate ), vinclozolin, vitamin D3, warfarin, xiaochongliulin, xinjunan, xiwojunan, enestrobin (xiwojunzhi), XMC, xylachlor, xylenols, xylylcarb, xymiazole, yishijing, cyanide Amine (zarilamid), zeatin, zengxiaoan, zengxiaolin, zeta-cypermethrin, zinc naphthalate, zinc phosphide, zinc thiazide (zinc thiazole), zinc thiozole, zinc trichlorophenate, zinc trichlorophenoxide, zineb, ziram, zolaprofos, Zoocoumarin, zoxamide, zuoanjunzhi, zuocaoan, zuojunzhi, zuomihuanglong, α-chlorohydrin Α-chlorohydrin, α-ecdysone, α-multistriatin, α-naphthaleneacetic acid, and β-ecdysone; (2 ) following molecule (a) N- (3- chloro-l- (pyridin-3-yl) lH-pyrazol-4-yl) -N- ethyl-3 - ((3,3,3-trifluoro Propyl) thio)propanamide (hereinafter referred to as " AI-1 ") (b) (3S,6S,7R,8R)-8-Benzyl-3-(3-((isobutyloxy)methoxy)-4-methoxypyridinecarboxamido)-6 -Methyl-4,9-dioxo-1,5-dioxanthene-7-ylisobutyrate ((3S,6S,7R,8R)–8–benzyl–3–(3–(( Isobutyryloxy)methoxy)–4–methoxypicolinamido)–6–methyl–4,9–dioxo–1,5–dioxonan–7–yl isobutyrate) (hereinafter referred to as “ AI–2 ”) (c) 4-Amino-3-chloro-6-(4-chloro-2-fluoro-3-methoxyphenyl)-5-fluoropicolinic acid ( hereinafter referred to as "AI-3") (3) A molecule called Lotilaner having the following structure And (4) the structure of the following molecular table A-M# -active ingredients in Table A

As used in this disclosure, each of the above is an active ingredient. For more information, check out the " Compendium of Pesticide Common Names " at Alanwood.net and the various versions of " The Pesticide Manual " at bcpcdata.com .

Particularly preferred active ingredients are selected from the group consisting of 1,3-dichloropropene, chlorpyrifos, hexaflumuron, methoxyfenozide, noifurumuron, spinetoram, and Spinosad, sulfoxaflor, and sulfonium fluoride (hereinafter referred to as " AIGA-2 ").

In addition, another particularly preferred active ingredient is acequinocyl, acetamiprid, acetoprole, avermectin, azinphos-methyl. , bifenazate, bifenthrin, carbaryl, carbofuran, chlorfenapyr, chlorfluazuron, chromafenozide, cotinine (clothianidin), cyfluthrin, cypermethrin, deltamethrin, diafenthiuron, emamectin benzoate, endosulfan , esfenvalerate, ethiprole, etoxazole, fipronil, flonicamid, fluacrypyrim, gamma-cylon ( gamma) -cyhalothrin), halofenozide, indoxacarb, lambda- cyhalothrin, lufenuron, malathion, methodill, novar Novaluron, permethrin, pyridalyl, pyrimidifen, schiffen (sp) Irodiclofen), tebufenozide, thiacloprid, thiamethoxam, thiodicarb, tolfenpyrad, and zeta- cypermethrin ( This is called " AIGA–3 ".

The term " alkenyl " means an acyclic, unsaturated (at least one carbon-carbon double bond), branched or unbranched substituent consisting of carbon and hydrogen, such as vinyl, allyl, butenyl, Pentenyl and hexenyl.

The term " alkenyloxy " means an alkenyl group further composed of a carbon-oxygen single bond, such as allyloxy, butenyloxy, pentenyloxy, hexenyloxy.

The term " alkoxy " refers to an alkyl group further composed of a carbon-oxygen single bond, such as methoxy, ethoxy, propoxy, isopropoxy, butoxy, and tertiary butoxy.

The term " alkyl " refers to acyclic, saturated, branched or unbranched substituents consisting of carbon and hydrogen, such as methyl, ethyl, propyl, isopropyl, butyl and tert-butyl.

The term " alkynyl " means an acyclic, unsaturated (at least one carbon-carbon ginseng), branched or unbranched substituent consisting of carbon and hydrogen, such as ethynyl, propargyl, butynyl and Pentynyl.

The term " alkynyloxy " means an alkynyl group further composed of a carbon-oxygen single bond, such as a pentynyloxy group, a hexynyloxy group, a heptynyloxy group, and an octynyloxy group.

The term " aryl " means a cyclic, aromatic substituent consisting of hydrogen and carbon, such as phenyl, naphthyl and biphenyl.

The term " biological insecticide " means a microbial type biological pest control agent, and is generally applied in a similar manner to a chemical insecticide. Usually they are of the bacterial type, but there are also examples of fungal control agents, including Trichoderma spp . and Ampelomyces quisqualis . An example of a well-known biological insecticide is the Bacillus species, which is a bacterial disease of the order Lepidoptera, Coleoptera, and Diptera. Biological insecticides include products based on insect pathogenic fungi (such as Metarhizium anisopliae ), insect pathogenic nematodes (such as Steinernema feltiae ), and insects. Pathogenic virus (such as Cydia pomonella granulosis virus). Other examples of insect pathogenic organisms include, but are not limited to, baculovirus, protozoa, and Microsporidia. For the avoidance of doubt, biological insecticides are active ingredients.

The term " cycloalkenyl " means a monocyclic or polycyclic, unsaturated (at least one carbon-carbon double bond) substituent consisting of carbon and hydrogen, such as cyclobutenyl, cyclopentenyl, cyclohexenyl, Decalene, bicyclo [2.2.2] octenyl, tetrahydronaphthyl, hexahydronaphthyl, and octahydronaphthalenyl.

The term " cycloalkenyloxy " refers to a cycloalkenyl group further composed of a carbon-oxygen single bond, such as a cyclobutenyloxy group, a cyclopentenyloxy group, a norborneneoxy group, and a bicyclo[2.2.2] octane. Alkenyloxy.

The term " cycloalkyl " refers to a monocyclic or polycyclic, saturated substituent consisting of carbon and hydrogen, such as cyclopropyl, cyclobutyl, cyclopentyl, norbornene, bicyclo [2.2.2] octyl and Decalin.

The term " cycloalkoxy " means a cycloalkyl group further composed of a carbon-oxygen single bond, such as cyclopropoxy, cyclobutoxy, cyclopentyloxy, norborneneoxy and bicyclo [2.2.2 ] octyloxy.

The term " halo " means fluoro, chloro, bromo and iodo.

The term " haloalkoxy " refers to alkoxy, which is further composed of one to the largest possible number of the same or different halogens, such as fluoromethoxy, trifluoromethoxy, 2,2-difluoropropoxy Base, chloromethoxy, trichloromethoxy, 1,1,2,2-tetrafluoroethoxy and pentafluoroethoxy.

The term " haloalkyl " refers to an alkyl group further composed of one to the largest possible number, the same or different halogens, such as fluoromethyl, trifluoromethyl, 2,2-difluoropropyl, chloromethyl, three Chloromethyl and 1,1,2,2-trifluoroethyl.

The term " heterocyclyl " means a cyclic substituent which may be aromatic, fully saturated, or partially or fully unsaturated, wherein the cyclic structure contains at least one carbon and at least one hetero atom, wherein the hetero atom is nitrogen, Sulfur or oxygen. Examples are: (1) an aromatic heterocyclic group substituents include, but are not limited to, benzofuranyl, benzo isothiazolyl, benzo iso Azolyl, benzothienyl, benzothiazolyl, benzo Azolyl, Cinnolinyl, furyl, imidazolyl, oxazolyl, fluorenyl, isodecyl, isoquinolinyl, isothiazolyl, iso Azolyl, Diazolyl, Oxazolinyl, Azolyl, anthracene Base Base, pyrazolinyl, pyrazolyl, anthracene Base, pyridyl, pyrimidinyl, pyrrolyl, quinazolinyl, quinolyl, quinoxalinyl, tetrazolyl, thiazolinyl, thiazolyl, thienyl, tri And triazolyl; (2) fully saturated heterocyclic substituents including, but not limited to, hexahydropyridyl a base, piperidinyl, morpholinyl, pyrrolidinyl, tetrahydrofuranyl, and tetrahydropyranyl; (3) a partially or fully unsaturated heterocyclic substituent including, but not limited to, 4,5-dihydro- different Azolyl, 4,5-dihydro- Azyl, 4,5-dihydro-1 H -pyrazolyl, 2,3-dihydro-[1,3,4]- Examples of oxadiazolyl, and 1,2,3,4-tetrahydroquinolinyl; and (4) additional heterocyclic groups include the following: Trimethylidene sulfide Trimethylidene-oxide vulcanized Trimethylene-dioxide.

The term " location " means a habitat, a nursery, a plant, a seed, a soil, a material, or an environment in which a pest will grow or pass. For example, the location may be: growing crops, trees, fruits, grains, feed types, grapes, turf, and/or ornamental plants; where captive animals live; interior or exterior surfaces of buildings (eg, storage of grain) Where)) construction materials used in the building (such as impregnated wood); and soil near the building.

The term " MoA material " means an active ingredient having the mode of action (" MoA ") as shown in irac-online.org., IRAC MoA Classification v. 7.4, describing the following groups.

(1) Acetylcholinesterase (AChE) inhibitors , including the following active ingredients: acephate, alanycarb, aldicarb, azamethiphos, ethyl valley Azinphos-ethyl, azinphos-methyl, bendiocarb, benfuracarb, butocarboxim, butoxycarboxim, cadusafos ), carbaryl, carbofuran, carbosulfan, chlorethoxyfos, chlorfenvinphos, chlormephos, chlorpyrifos, Chlorpyrifos-methyl, coumaphos, cyanophos, methyl endophos-S, diazinon, dichlorvos/DDVP, bistroxine Dicrotophos), dimethoate, dimethylvinphos, disulfoton, EPN, ethiofencarb, ethion, ethoprophos, Famphur, fenamiphos, fenitrothion, fenobucarb, fenthion, Eta form (formetanate), fosthiazate, furathiocarb, heptenophos, imicyafos, isofenphos, isoprocarb, iso Propyl O-(methoxyaminothio-phosphonium) salicylate, isoxathion, malathion, mecarbam, methamidophos, dexamethasone (methidathion), metiocarb, methomyl, metolcarb, mevinphos, monocrotophos, Naled, omethoate ), oxamyl, oxydemeton-methyl, parathion, methyl balason, phenthoate, phorate, phosalone, Phosmet, phosphamidon, phoxim, pirimicarb, pirimiphos-methyl, profenofos, propetamphos, Propoxur, prothiofos, pyraclofos, pyridaphenthion, quinalphos, sulfotep, butyl Tebupirimfos, temephos, terbufos, tetrachlorvinphos, thiodicarb, thiofanox, thiometon, oxazolide (triazamate), triazophos, trichlorfon, trimethacarb, vamidothion, XMC, and xylylcarb. (2) GABA-thyristing chloride channel antagonists , including the following active ingredients: chlordane, endosulfan, ethiprole, and fipronil. (3) sodium channel modulators, comprising the following active ingredients: Ana Ning (acrinathrin), Ya Liening (allethrin), dextrose - cis - trans-chloropropyl prallethrin (d-cis-trans allethrin) , dextrorotatory trans-chloropropyl prallethrin (d-trans -allethrin), Bifen Ning (bifenthrin), one hundred Ya Liening (bioallethrin), S- cyclopentenyl one hundred Ya Liening (bioallethrin S-cyclopentenyl), bioresmethrin (bioresmethrin ), B cyhalothrin (cycloprothrin), SIFE Ning (cy fl uthrin), β- SIFE Ning, xeronine (cyhalothrin), λ- xeronine (lambda- cyhalothrin), γ- xeronine, race deltamethrin (cypermethrin), α-赛灭宁, β-赛灭宁, θ-赛灭宁, ζ-赛灭宁, 赛素宁 [(1 R) -trans- isomer] (cyphenothrin [(1 R ) -trans -isomers]), deltamethrin (deltamethrin), beneficial to avoid Ning [(EZ) - (1 R ) - isomer] (empenthrin [(EZ) - (1 R) -isomers]), the benefits of Esfenvalerate, etofenprox, fenpropathrin, fenvalerate, flucythrinate, flumethrin, tau- fluvalinate ), Hefen (halfenprox), according Puning (imiprothrin), thiophene ah permethrin (kadethrin), permethrin (permethrin), phenol Ding Miening [(1 R) - trans - isomer] (phenothrin [(1 R) - Trans- isomer]), prallethrin, pyrethrin (pyrethrum), pyrethyrrin, silafluofen, tefluthrin, Terpene (tetramethrin), sputum [(1 R )-isomer], tramomethrin, and methoxychlor. (4) type nicotinic acetylcholine (the nAChR) competitive modulators, comprising the following active ingredients: (4A) alkylene off culture (, acetamiprid), clothianidin (, clothianidin), epoxy insect piperidine (cycloxaprid), Dart Dinotefuran, huanyanglin, imidacloprid, nitiazine, nitenpyram, thiacloprid, thiamethoxam, (4B ) nicotine, (4C) fluoro sulfoxaflor (sulfoxaflor), (4D) contained Fulong Fubi Nan (flupyradifurone), (4E) Sanford off reserving Lin (triflumezopyrim) and dichloro-off seat for (dicloromezotiaz). (5) type nicotinic acetylcholine receptors (the nAChR) allosteric modulators, comprising the following active ingredients: Knott give (spinetoram,) and spinosad (spinosad). (6) Chloride channel activators , including the following active ingredients: abamectin, emamectin benzoate, eprinomectin, lycopene (lepimectin), milbemectin, and moxidectin. (7) Juvenile hormone mimics , including the following active ingredients: hydroprene, kinoprene, metoprene, fenoxycarb, and bailipfen ( Pyriproxyfen). (8) Heterogeneous non-specific ( multi-site) inhibitors , including the following active ingredients: methyl bromide, chloropicrin, sulfonium fluoride, borax, boric acid, disodium octaborate, sodium borate, sodium metaborate, spit Tartar, diazomet, and metam. (9) open string organs (Chordotonal Organs) modulators, comprising the following active ingredients: send off the net (pymetrozine) and niflumic amine (flonicamid). (10) 螨 growth inhibitors , including the following active ingredients: clefentezine, hexythiazox, fluoroquinone (diflovidazin), and by etoxazole. (11) Microorganisms that destroy the intestinal membrane of insects , including the following active components: Bacillus thuringiensis subsp. israelensis , Bacillus thuringiensis subsp. aizawai , Suricus cusia ( Bacillus thuringiensis subsp. kurstaki ), Bacillus thuringiensis subsp. tenebrionenis , Bt crop proteins (Cry1Ab, Cry1Ac, Cry1Fa, Cry1A.105, Cry2Ab, Vip3A, mCry3A, Cry3Ab, Cry3Bb, Cry34Ab1/Cry35Ab1), and Bacillus sphaericus . (12) Granular gland ATP synthase inhibitors , including the following active ingredients: tetradifon, propargite, azocyclotin, cyhexatin, fenbutatin Oxide), and diafenthiuron. (13) An oxidative phosphorylation non-coupling agent that destroys a proton gradient , including the following active ingredients: chlorfenapyr, DNOC, and sulfluramid. (14) type nicotinic acetylcholine receptors (the nAChR) channel blockers, including the following active ingredients: Free Speed up (bensultap), Peidan hydrochloride (cartap hydrochloride), thanks Ann sulfur (, thiocyclam,), and kill Sodium thiosultap-sodium. (15) Chitin biosynthesis inhibitor, type 0 , including the following active ingredients: bistrifluron, chlorfluazuron, diflubenzuron, flucycloxuron, flufen Flufenoxuron, hexaflumuron, lufenuron, novaluron, noviflumuron, teflubenzuron, and triflumuron. (16) Chitinogenic synthesis inhibitor, type 1 , including the following active ingredient: buprofezin. (17) Diptera peeling interferer , including the following active ingredients: cyromazine. (18) A ecdysone receptor synergist comprising the following active ingredients: chromafenozide, halofenozide, methoxyfenozide, and tebufenozide. (19) Octopamine receptor synergist comprising the following active ingredient: amitraz. (20) Granular gland complex III electron transport inhibitor , comprising the following active ingredients: hydramethylnon, acequinocyl, and fluacrypyrim. (21) Granular gland complex I electron transport inhibitors , including the following active ingredients: fenazaquin, fenpyroximate, pyrimidifen, pyridaben, defenyl (tebufenpyrad), tolfenpyrad, and rotenone. (22) Voltage- dependent sodium channel blockers , including the following active ingredients: indoxacarb and metaflumizone. (23) Acetylpyrase A carboxylase inhibitor , comprising the following active ingredients: spirodiclofen, spiromesifen, and spirotetramat. (24) Granular gland complex IV electron transport inhibitor comprising the following active ingredients: aluminum phosphide, calcium phosphide, phosphine, zinc phosphide, and cyanide. (25) mitochondrial complex II electron transport inhibitors comprises the following active ingredients: cyanomethyl oxazole mite (cyenopyrafen), Saifun mite (Cyflumetofen and), and send Fubu Min (pyflubumide), and (28) by Luona Dan is (R yanodine receptor) modulators, comprising the following active ingredients: Kean Bo (chlorantraniliprole), cyano insect Amides (cyantraniliprole), and large-fluoro-off (flubendiamide).

This version of the classification system is not assigned Groups 26 and 27. In addition, there are active ingredient groups of UN containing unknown or indeterminate modes of action. This group includes the following active ingredients: azadirachtin, benzoximate, bifenazate, bromopropylate, chinomethionat, cryolite, large Dicofol, pyridalyl, and pyrifluquinazon.

The term " pest " means an organism that is harmful to humans or things that humans care about (such as crops, food, livestock, etc.) from arthropods, mollusks, or circles. Shaped animal door. Specific examples are ants, mites, bed bugs, beetles, bristletails, caterpillars, crickets, crickets, earwigs, fleas, flies, crickets, crickets, bumblebees, jassids. , leafhoppers, leaf miners, crickets, locusts, crickets, melybugs, crickets, moths, nematodes, plant bugs, planthoppers, psyllids, saws Sawflies, scale insects, silverfish, crickets, snails, spiders, snails, bed bugs, symphylans, termites, thrips, ticks, wasps, whiteflies, and nematodes ( Wireworm).

Additional examples are the following pests: (1) Subphyla Chelicerata , Myriapoda , and Hexapoda . (2) Arachnida (Arachnida), Symphyla (Symphyla), and Insecta (Insecta). (3) Head lice (Order Anoplura). A non-exhaustive list of specific genera includes, but is not limited to, Haematopinus spp., Hoplopleura spp., Linognathus spp., Pediculus spp. Polyplax spp., Solenopotes spp., and Neohaematopinis spp. A non-exhaustive list of specific species includes, but is not limited to, Haematopinus asini , Haematopinus suis , Linognathus setosus , Linognathus ovillus , Pediculus humanus Capitis ), Pediculus humanus humanus and Pthirus pubis . (4) Coleoptera (Order Coleoptera) . A non-exhaustive list of specific genera includes, but is not limited to, Acanthoscelides spp., Agriotes spp., Anthonomus spp., Apion spp., and golden tortoise Genus ( Apogonia spp.), ( Araecerus spp.), Aulacophora spp., Bruchus spp., Cerosterna spp., Cerotoma spp. , genus ( Ceutorhynchus spp.), Chaetocnema spp., Colaspis spp., Ctenicera spp., Curculio spp., round head Cyclocephala spp., Diabrotica spp., Dinoderus spp., Gnathocerus spp., Hemicoelus spp., Aphididae Genus ( Heterobostruchus spp.), Hypericoptera ( Hyla spp.), Ips spp., Lyctus spp., Megascelis spp., genus Meligethes spp.), Mezium spp., Niptus spp., Otiorhynchus spp., Pantomorus spp., genus ( Phyllophaga spp.), Phyllotreta spp., Ptinus spp., Rhizotrogus spp., Rhynchites spp., Elephant genus Rhynchophorus spp.), Scolytus spp., Sphenophorus spp., Sitophilus spp., Tenebrio spp., and Quercus Tribolium spp.). A non-exhaustive list of specific species includes, but is not limited to, Acanthoscelides obtectus , Agrilus planipennis , Ahasverus advena , Alphitobius diaperinus , A. glabrata ( Anoplophora glabripennis ), Anthonomus grandis , Anthrenus verbasci , Anthrenus falvipes , Ataenius spretulus , Atomaria linearis , black fur Attagenus unicolor , Bothynoderes punctiventris , Bruchus pisorum , Callosobruchus maculatus , Carpophilus hemipterus , Cassida vittata , square neck squad Cathartus quadricollis ), Cerotoma trifurcata , Ceutorhynchus assimilis , Ceutorhynchus napi , Conoderus scalaris , Conoderus stigmosus , Li Weevil ( Conotrachelus nenuphar ), green turtle ( Cotinis nitida ) , Aspartic Golden worm (Crioceris asparagi), flat rust red flour beetle (Cryptolestes ferrugineus), Longhorn flat castaneum (Cryptolestes pusillus), Turkey flat castaneum (Cryptolestes turcicus), adhesion points twigs weevil (Cylindrocopturus adspersus) , Deporaus marginatus , Dermestes lardarius , Dermestes maculatus , Epilachna varivestis , Euvrilletta peltata , Faustinus cubae ), Hylobius pales , Hylotrupes bajulus , Hypera postica , Hypothenemus hampei , Lasioderma serricorne , Leptinotarsa decemlineata , Limonius canus , Liogenys fuscus , Liogenys suturalis , Lissorhoptrus oryzophilus , Lophocateres pusillus , Lyctus planicollis ), Maecolaspis joliveti , Melanotus communis , canola Meligethes aeneus , Melolontha melolontha , Necrobia rufipes , Oberea brevis , Oberea linearis , Oryctes rhinoceros , Oryzaephilus mercator , Oryzaephilus surinamensis , Oulema melanopus , Oulema oryzae , Phyllophaga cuyabana , Polycaon stoutti ), Popillia japonica , Prostephanus truncatus , Rhyzopertha dominica , Sitona lineatus , Sitophilus granarius , Sitophilus oryzae , corn ( Sitophilus zeamais ), Stegobium paniceum , Tenebroides mauritanicus , Tribolium castaneum , Tribolium confusum , Trogoderma granarium , tinea skin ( Trogoderma variabile ), red thief ( Xestobium rufovillosum ), and corn beetle ( Zabrus tenebrioides). (5) Dermaptera (Order Dermaptera). A non-exhaustive list of specific genera includes, but is not limited to, Forficula auricularia . (6) Blattaria (Order Blattaria). A non-exhaustive list of specific species includes, but is not limited to, Blattella germanica , Blattella asahina , Blatta orientalis , Blatta lateralis , Pennsylvania Parcoblatta pennsylvanica , Periplaneta americana , Periplaneta australasiae , Periplaneta brunnea , Periplaneta fuliginosa , Pycnoscelus surinamensis , and long beard With 蠊 ( Supella longipalpa ). (7) Diptera (Order Diptera). A non-exhaustive list of specific genera includes, but is not limited to, Aedes spp., Agromyza spp., Anastrepha spp., Anopheles spp. fruit fly genus (Bactrocera spp.), is a Mediterranean fruit fly (Ceratitis spp.), is a spot fly (Chrysops spp.), worm fly genus (Cochliomyia spp.), midge genus (Contarinia spp.), house mosquito genera ( Culex spp.), Culicoides spp., Dasineura spp., Delia spp., Drosophila spp., Fannia spp. , black flies genus (Hylemya spp.), is a leafminer (Liriomyza spp.), is a housefly (Musca spp.), is a grass flies (Phorbia spp.), powder Musca (Pollenia spp.), moth gnats genus (Psychoda spp.), Simulium (Simulium spp.), is a horsefly (Tabanus spp.) and large mosquito genera (Tipula spp.). Non-exhaustive lists of specific species include, but are not limited to, Agromyza frontella , Anastrepha suspensa , Anastrepha ludens , Anastrepha obliqua, and melon Bactrocera cucurbitae , Bactrocera dorsalis , Bactrocera invadens , Bactrocera zonata , Ceratitis capitata , Dasineura brassicae , ash species Fly ( Delia platura ), Fannia canicularis , Fannia scalaris , Gasterophilus intestinalis , Gracillia perseae , Haematobia irritans , Hypoderma lineatum , vegetable leaf miner (Liriomyza brassicae), vegetable leafminer (Liriomyza sativa), sheep ticks (Melophagus ovinus), autumn housefly (Musca autumnalis), the common housefly (Musca domestica), sheep mad fly (Oestrus ovis), black straw flies (Oscinella frit), beet spring flies (Pegomya betae), Kai's cheese flies (Piophila casei), Hu Bu flies (Psila rosae), cherry fruit fly (Rhagoletis cerasi), apple fruit fly (Rhagoletis pomonella), Blue Orange around the fruit fly (Rhagoletis mendax), wheat midge (Sitodiplosis mosellana) and廄stable flies (Stomoxys calcitrans). (8) Hemiptera (Order Hemiptera). A non-exhaustive list of specific genera includes, but is not limited to, Adelges spp., Aulacaspis spp., Aphrophora spp., Aphis spp. Bemisia spp., Ceroplastes spp., Chionaspis spp., Chrysomphalus spp., Coccus spp. Empeoasca spp., Euschistus spp., Lepidosaphes spp., Lagynotomus spp., Lygus spp., long Macrosiphum spp., Nephotettix spp., Nezara spp., Nilaparvata spp., Philaenus spp., Phytophthora Genus ( Phytocoris spp.), genus Piezodorus spp., Planococcus spp., Pseudococcus spp., Rhopalosiphum spp., black helmet Saissetia spp., Therioaphis spp., Toumeyella spp., Toxoptera spp., Trial Eurodes spp.), Triatoma spp., and Unaspis spp. A non-exhaustive list of specific species includes, but is not limited to, Acrosternum hilare , Acyrthosiphon pisum , Aleyrodes proletella , Aleurodicus dispersus , and Aleurothrixus floccosus ), Amrasca biguttula biguttula , Aonidiella aurantii , Aphis fabae , Aphis gossypii , Aphis glycines , Aphis pomi , potato aphid (Aulacorthum solani), potato / tomato psyllid (Bactericera cockerelli), cabbage bugs charge domains (Bagrada hilaris), silverleaf whitefly (Bemisia argentifolii), silverleaf whitefly (Bemisia tabaci), chinch bugs (Blissus leucopterus), Boisea trivittata , Brachycorynella asparagi , Brevennia rehi , Brevicoryne brassicae , Cacopsylla pyri , Cacopsylla pyricola , Potato Jun Calocoris norvegicus , Ceroplastes rubens , tropical bugs ( Cime) x hemipterus ), Cimex lectularius , Coccus pseudomagnoliarum , Dagbertus fasciatus , Dichelops furcatus , Diuraphis noxia , Diaphorina citri , Dysaphis plantaginea), black-winged red cotton bug (Dysdercus suturellus), Edessa meditabunda, false eye leafhopper (Empoasca vitis), woolly apple aphid (Eriosoma lanigerum), western grape leafhopper (Erythroneura elegantula), European flat shield bug (Eurygaster maura ), Euschistus conspersus , Euschistus heros , Euschistus servus , Halyomorpha halys , Helopeltis antonii , Hyalopterus pruni Helopeltis antonii , Helopeltis theivora , Icerya purchasi , Idioscopus nitidulus , Jacobiasca formosana , zebrafish ( Laodelphax striatellus ), Lecanium corni , Leptocorisa ora Torius ), Leptocorisa varicornis , Lygus hesperus , Maconellicoccus hirsutus , Macrosiphum euphorbiae , Macrosiphum granarium , Rose long Macrosiphum rosae , Macrosteles quadrilineatus , Mahanarva frimbiolata , Megacopta cribraria , Metopolophium dirhodum , Mictis longicornis , peach Myzus persicae , Nasonovia ribisnigri , Nephotettix cincticeps , Neurocolpus longirostris , Nezara viridula , Nilaparvata lugens , Paracoccus marginatus , Paratrioza cockerelli , Parlatoria pergandii , Parlatoria ziziphi , Peregrinus maidis , Phylloxera vitifoliae , cedar Kuwana (Physokermes piceae), California plant bugs (Phytocoris californicus), Lygus (Phytocoris relativus), intended GED wall bug (Piezodorus guildinii), orange buttocks pattern mealybug (Planococcus citri), the gluteal groove fig mealybug (Planococcus ficus), four-wire bugs (Poecilocapsus lineatus), Lygus (Psallus vaccinicola), avocado stink bugs (Pseudacysta perseae), clean pineapple mealybugs (Pseudococcus brevipes), pear shield Kuwana (Quadraspidiotus perniciosus), corn aphid (Rhopalosiphum maidis), rice wheat aphid (Rhopalosiphum padi), Lam beads wax scale ( Saissetia oleae ), Scaptocoris castanea , Schizaphis graminum , Sitobion avenae , Sogatella furcifera , Trialeurodes vaporariorum , and winged wings Trionyurodes abutiloneus , Unaspis yanonensis and Zulia entrerriana . (9) Hymenoptera (Order Hymenoptera). A non-exhaustive list of specific genera includes, but is not limited to, Acromyrmex spp., Atta spp., Camponotus spp., Diprion spp. , Dolichovespula spp., Formica spp., Monomorium spp., Neodiprion spp., Paratrechina spp., antler Genus ( Pheidole spp.), Pogonomyrmex spp., Polistes spp., Solenopsis spp., Technomyrmex , spp., Tetramorium Spp.), Vespula spp., Vespa spp., and Xylocopa spp. A non-exhaustive list of specific species includes, but is not limited to, Athalia rosae , Atta texana , Caliroa cerasi , American horned bee ( Cimbex americana ), Aridomyrmex humilis , Linepithema humile , Mellifera Scutellata , Monomorium minimum , Monomorium pharaonis , Pine yellow leaves Neodiprion sertifer , Solenopsis invicta , Solenopsis geminata , Solenopsis molesta , Solenopsis richtery , Solenopsis xyloni , sour odorant Tapinoma sessile ), and the small fire ant ( Wasmannia auropunctata ). (10) Isoptera (Order Isoptera). A non-exhaustive list of specific genera includes, but is not limited to, Coptotermes spp., Cornitermes spp., Cryptotermes spp., Heterotermes spp. wood termites belong (Kalotermes spp.), Ying termites belong (Incisitermes spp.), termites belong (Macrotermes spp.), edge wood termite genus (Marginitermes spp.), saw termite genus (Microcerotermes spp.), the original angle termites Genus ( Procornitermes spp.), Reticulitermes spp., Schedorhinotermes spp. and Zootermopsis spp. A non-exhaustive list of specific species includes, but is not limited to, ( Coptotermes acinaciformis ), Coptotermes curvignathus , Coptotermes frenchii , Coptotermes formosanus , Coptotermes gestroi), hemp head heap of sand termites (Cryptotermes brevis), golden different termite (Heterotermes aureus), South America different termite (Heterotermes tenuis), small Ying termites (Incisitermes minor), Sri Lanka's Ying termites (Incisitermes snyderi), rice and wheat small termite ( Microtermes obesi ), Nasutitermes corniger , Odontotermes formosanus , Odontotermes obesus , Reticulitermes banyulensis , Reticulitermes grassei , Termites ( Reticulitermes flavipes ), Reticulitermes hageni , Reticulitermes hesperus , Reticulitermes santonensis , Reticulitermes speratus , Reticulitermes tibialis and nice Black subterranean termite (Reticulitermes virginicus). (11) Lepidoptera (Order Lepidoptera) . A non-exhaustive list of specific genera includes, but is not limited to, Adoxophyes spp., Agrotis spp., Argyrotaenia spp., Cacoecia spp. Caloptilia spp., Chilo spp., Chrysodeixis spp., Colias spp., Crambus spp., wilderness Diaphania spp., Diatraea spp., Earias spp., Ephestia spp., Epimecis spp., Spodoptera spp. Feltia spp.), Gortyna spp., Helicoverpa spp., Heliothis spp., Indarbela spp. , Locusta ( Lithocolletis spp.), Loxagrotis spp., Malacosoma spp., Nemapogon spp., Peridroma spp., genus Phyllonorycter spp.), Pseudaletia spp., Plutella spp., Sesamia spp., Spodoptera spp., Syringa ( Sy) Nanthedon spp.) and Yponomeuta spp. A non-exhaustive list of specific species includes, but is not limited to, Achaea janata , Adoxophyes orana , Agrotis ipsilon , Alabama argillacea , Amorbia cuneana , Amyelois transitella , Anacamptodes defectaria , Anarsia lineatella , Anomis sabulifera , Anticarsia gemmatalis , Archips argyrospila , Archips rosana , Argyrotaenia citrana , Autographa gamma , Bonagota cranaodes , Borbo cinnara ), cotton moth ( Bucculatrix thurberiella ), Capua reticulana , Carposina niponensis , Chlumetia transversa , Choristoneura rosaceana , and rice leaf roller ( Cnaphalocrocis medinalis), cocoa miner (Conopomorpha cramerella), rice conjugated outer moth (Corcyra cephalonica), Cossus moth (Cossus cossus), Walnut moth (Cydia caryana), Li moth (Cydia funebrana), pear moth (Cydia molesta), a small pea moth (Cydia nigricana), codling moth (Cydia pomonella), tea slug (Darna diducta), cucumber Diaphania nitidalis , Diatraea saccharalis , Diatraea graniosella , Earias insulata , Earias vitella , small rolls Ecdytolopha aurantianum , South American corn seedlings ( Elasmopalpus lignosellus ), Ephestia cautella, Ephestia elutella , Ephestia kuehniella , Epinotia aporema , light brown Epiphyas postvittana , Erionota thrax , Estigmene acrea , Eupoecilia ambiguella , Euxoa auxiliaris , Galleria mellonella , peach off heartworm (Grapholita molesta), three lines Pyralidae (Hedylepta indicata), cotton bollworm (Helicoverpa armigera), corn earworm (He Licoverpa zea ), Heliothis virescens , Hellula undalis , Keiferia lycopersicella , Leucinodes orbonalis , Leucoptera coffeella , striated dive Leucoptera malifoliella , Lobesia botrana , Loxagrotis albicosta , Lymantria dispar , Lyonetia clerkella , Mahasena corbetti , Mamestra brassicae , Manduca sexta , Maruca testulalis , Metisa plana , Mythimna unipuncta , Neoleucinodes elegantalis , White-water moth ( Nymphula depunctalis ), Operophtera brumata , Ostrinia nubilalis , Oxydia vesulia , Pandemis cerasana , Pandemis heparana , Africa Damour butterfly (Papilio demodocus), white coffee latent night insects (Pectinophora gossypiella), variegated armyworm (Peridroma saucia) Coffee leafminer (Perileucoptera coffeella), potato moth (Phthorimaea operculella), citrus latent armyworm (Phyllocnisitis citrella), spot curtain leafminer (Phyllonorycter blancardella), grain white butterfly (Pieris rapae), alfalfa green armyworm (Plathypena scabra) , Platynota idaeusalis , Plodia interpunctella , Plutella xylostella , Polychrosis viteana , Prays endocarpa , Prays oleae , Pseudaletia unipuncta , Pseudoplusia includens , Rachiplusia nu , Scirpophaga incertulas , Sesamia inferens , Sesamia Nonagrioides ), Setora nitens , Sitotroga cerealella , Sparganothis pilleriana , Spodoptera exigua , Spodoptera fugiperda , Southern Spodoptera (Spodoptera eridania), pineapple gray brown butterfly (Thecla basilides), Moth (Tinea pellionella), webbing clothes moth (Tineola bisselliella), pink spots armyworm (Trichoplusia ni), tomato leafminer (Tuta absoluta), coffee leopard moth (Zeuzera coffeae) and pear leopard moth (Zeuzera pyrina). (12) Mallophaga (Order Mallophaga). A non-exhaustive list of specific genera includes, but is not limited to, Anaticola spp., Bovicola spp., Chelopistes spp., Goniodes spp. ), Menacanthus spp. and Trichodectes spp. Non-exhaustive lists of specific species include, but are not limited to, Bovicola bovis , Bovicola caprae , Bovicola ovis , Chelopistes meleagridis , and chicken horns ( Goniodes dissimilis ), Goniodes gigas , Menacanthus stramineus , Menopon gallinea , and Trichodectes canis . (13) Orthoptera (Order Orthoptera). A non-exhaustive list of specific genera includes, but is not limited to, Melanoplus spp. and Pterophylla spp. Non-exhaustive lists of specific species include, but are not limited to, Acheta domesticus , Anabrus simplex , Gryllotalpa africana , Gryllotalpa australis , Gryllotalpa brachyptera , Gryllotalpa hexadactyla , Locusta migratoria , Microcentrum retinerve , Schistocerca gregaria , and Scudderia furcata . (14) Psocoptera (Order Psocoptera). A non-exhaustive list of specific species includes, but is not limited to, Liposcelis decolor , Liposcelis entomophila , Lachesilla quercus , and Trogium pulsatorium . (15) Siphonaptera (Order Siphonaptera). A non-exhaustive list of specific species includes, but is not limited to, Ceratophyllus gallinae , Ceratophyllus niger , Ctenocephalides canis , Ctenocephalides felis , and People ( Pulex irritans ). (16) Thysanoptera (Order Thysanoptera). A non-exhaustive list of specific genera includes, but is not limited to, Caliothrips spp., Frankliniella spp., Scirtothrips spp., and Thrips spp. .). A non-exhaustive list of specific species includes, but is not limited to, Caliothrips phaseoli , Frankliniella bispinosa , Frankliniella fusca , Frankliniella occidentalis , Frankliniella schultzei , Frankliniella tritici , Frankliniella williamsi , Heliothrips haemorrhaidalis , Rhipiphorothrips cruentatus , orange hard Scirtothrips citri , Scirtothrips dorsalis , Taeniothrips rhopalantennalis , Thrips hawaiiensis , Thrips nigropilosus , Thrips orientalis , Thrips palmi , and Thrips tabaci . (17) Thysanoptera (Order Thysanura). A non-exhaustive list of specific genera includes, but is not limited to, Lepisma spp. and Thermobia spp. (18) Acarina (Order Acarina). A non-exhaustive list of specific genera include but are not limited to, metal powder mite (Acarus spp.), Ticks genus puncture the skin section (Aculops spp.), Argus genus (Argus spp.), Cattle ticks genus (Boophilus spp.) , Demodex spp., Dermacentor spp., Epitimerus spp., Eriophyes spp., Ixodes spp., red leaves Oligonychus spp., Panonychus spp., Rhizoglyphus spp., and Tetranychus spp. A non-exhaustive list of specific species includes, but is not limited to, Acarapis woodi , Acarus siro , Aceria mangiferae , Aculops lycopersici , and skin. Aculus pelekassi , Aculus schlechtendali , Amblyomma americanum , Brevipalpus obovatus , Brevipalpus phoenicis , variant leather Dermacentor variabilis , Dermatophagoides pteronyssinus , Eotetranychus carpini , Liponyssoides sanguineus , Notoedres cati , Oligonychus coffe a e ), Oligonychus ilicis , Ornithonyssus bacoti , Panonychus citri , Panonychus ulmi , Phyllocoptruta oleivora , Polyphagotarsonemun latus , Rhipicephalus sanguineus , Sarcoptes scabiei , crocodile Tegolophus perseaflorae , Tetranychus urticae , Tyrophagus longior , and Varroa destructor . (19) True Spiders (Order Araneae). A non-exhaustive list of specific genera include but are not limited to, belong to the swash spider (Loxosceles spp.), The genus widow spider (Latrodectus spp.), And the genus funnel spider (Atrax spp.). A non-exhaustive list of specific species includes, but is not limited to, Loxosceles reclusa , Latrodectus mactans , and Atrax robustus . (20) a valve junction classes (Class Symphyla). A non-exhaustive list of specific species includes, but is not limited to, Scutigerella immaculata . (21) Viscosity tube subclass (Subclass Collembola). Non-exhaustive lists of specific species include, but are not limited to, Bourletiella hortensis , Onychiurus armatus , Onychiurus fimetarius , and Sminthurus viridis . (22) round the phylum (Phylum Nematoda). A non-exhaustive list of specific genera includes, but is not limited to, Aphelenchoides spp., Belonolaimus spp., Criconemella spp., Ditylenchus spp., gold. Globodera spp., Heterodera spp., Hirschmanniella spp., Hoplolaimus spp., Meloidogyne spp., Rhizoctonia genus ( Prtylenchus spp.) and the genus Radopholus spp. A non-exhaustive list of specific species includes, but is not limited to, Dirofilaria immitis , Globodera pallida , Heterodera glycines , Heterodera zeae , Southern Meloidogyne incognita , Meloidogyne javanica , Onchocerca volvulus , Pratylenchus penetrans , Radopholus similis , and Renal nematodes ( Rotylenchus) Reniformis ). (23) Mollusc ( Phylum Mollusca ) . Non-exhaustive lists of specific species include, but are not limited to, Arion vulgaris , Cornu aspersum , Deroceras reticulatum , Limax flavus , Milax gagates , And Pomacea canaliculata .

A group of pests that are particularly well controlled are pests that feed on juice. Pests that feed on sap , in general, have sharp and/or sucking mouthparts and feed on the internal plant tissues of the juice and plants. Examples of pests that are of particular interest to agriculture in agriculture include, but are not limited to, aphids, spider mites, moths, scales, thrips, psyllids, melybugs, bed bugs. , and pink. Specific examples of pests of agricultural concern for feeding sap include, but are not limited to, Order Anoplura and Order Hemiptera. Specific examples of Hemiptera of agricultural concern include, but are not limited to, Aulacaspis spp., Aphrophora spp., Aphis spp., Bemisia spp. , Coccus spp., Euschistus spp., Lygus spp., Macrosiphum spp., Nezara spp., and Rhopalosiphum spp.

Another group of pests that are particularly well controlled are chewing pests. Chewing pests , in general, have sharp and/or sucking mouthparts that allow them to chew plant tissue, including roots, stems, leaves, and reproductive tissues (including but not limited to flowers, fruits, and seeds). Examples of chewing pests of agricultural interest include, but are not limited to, caterpillars, beetles, mites, and mites. Specific examples of agriculturally focused chewing pests include, but are not limited to, Coleoptera and Lepidoptera. Specific examples of coleoptera of agricultural concern include, but are not limited to, Acanthoscelides spp., Cerotoma spp., Chaetocnema spp., Colaspis spp. ), Cyclocephala spp., Diabrotica spp., Hypera spp., Phyllophaga spp., Phyllotreta spp. , Sphenophorus spp., Sitophilus spp.

The term " insecticidally effective amount " means the insecticidal dose required to achieve an observable effect on a pest, for example, the effects of necrosis, death, delay, prevention, removal, destruction, or otherwise reduce the pest in one location. Occurrence and/or activity of pests. This effect can occur when a pest population is expelled at a location where the pest is incapable at or near a location and/or when the pest is destroyed at or near a location. Of course, a combination of these effects can occur. In general, the pest population, activity, or both are desirably reduced by more than fifty percent, preferably by more than ninety percent, and most preferably by more than ninety-nine percent. Generally, for agricultural purposes, the pesticidally effective amount is from about 0.0001 grams per hectare to about 5000 grams per hectare, preferably from about 0.0001 grams per hectare to about 500 grams per hectare, and still more preferably from about 0.0001 per hectare. The gram is about 50 grams per hectare.

DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS This document discloses Formula 1 molecule Formula 1 ^{wherein: (A) R 1, R} 2, R 3, R 4, R 5, R 7, R 8, R 9, and R ¹⁰ are each independently selected from the Department of H, F, Cl, Br, I , CN, NO ₂ , OH, (C ₁ -C ₄ )alkyl, (C ₂ -C ₄ )alkenyl, (C ₁ -C ₄ )haloalkyl, (C ₁ -C ₄ )alkoxy, (C ₁ -C ₄ ) haloalkoxy, and (C ₃ -C ₆ )cycloalkyl, wherein each alkyl, alkenyl, haloalkyl, alkoxy, haloalkoxy, cycloalkyl Optionally substituted with one or more substituents independently selected from the group consisting of H, F, Cl, Br, I, CN, NO ₂ , OH, (C ₁ -C ₄ )alkyl, (C ₂ -C ₄ )alkenyl, (C ₁ -C ₄ )haloalkyl, (C ₁ -C ₄ )alkoxy, (C ₁ -C ₄ )haloalkoxy, and (C ₃ -C ₆ ) a cycloalkyl group; (B) R ⁶ is H; (C) L is selected from the group consisting of (1) a bond linking a nitrogen to a ring carbon, and (2) a (C ₁ -C ₄ ) alkyl group, wherein The alkyl group is optionally substituted with one or more substituents independently selected from the group consisting of F, Cl, CN, OH and pendant oxygen; (D) R ¹¹ is selected from the group consisting of _{group: H, (C 1 -C 4} ) alkyl, (C ₂ -C ₄₎ alkenyl, (C ₂ -C ₄₎ Alkoxy, (C ₂ -C ₄₎ alkynyl, (C ₂ -C ₄₎ alkynyloxy, (C ₁ -C ₄₎ haloalkyl, (C ₁ -C ₄₎ alkoxy, (C ₁ - C ₄ ) haloalkoxy, (C ₃ -C ₆ )cycloalkyl, (C ₃ -C ₆ )cycloalkoxy, (C ₃ -C ₆ )cycloalkenyl, (C ₃ -C ₆ ) ring Alkenyloxy, ((C ₁ -C ₄ )alkyl ((C ₃ -C ₆ )cycloalkyl), C(O)((C ₁ -C ₄ )alkyl), ((C ₁ -C _{4 )} )alkyl)C(O)((C ₁ -C ₄ )alkyl), ((C ₁ -C ₄ )alkyl)C(O)O((C ₁ -C ₄ )alkyl), and C (S)NH ₂ , wherein each alkyl, alkenyl, alkenyloxy, alkynyl, alkynyloxy, haloalkyl, alkoxy, haloalkoxy, cycloalkyl, cycloalkoxy, cycloalkene group, and a cycloalkenyl group optionally system to the one or more substituents independently selected from the following substituent group to be substituted with: _2, OH and the oxygen side H, F, Cl, Br, I, CN, NO; ( E) R ¹² and R ¹³ are (G) or each independently selected from the group consisting of H, (C ₁ -C ₄ )alkyl, (C ₂ -C ₄ )alkenyl, (C ₂ -C ₄ ) alkynyl, (C ₁ -C ₄ )haloalkyl, ((C ₁ -C ₄ )alkyl((C ₃ -C ₆ )cycloalkyl), (C ₁ -C ₄ )alkyl Phenyl, (C ₁ -C ₄ )alkylheterocyclyl, ((C ₁ -C ₄ )alkyl)C(O)((C ₁ -C ₄ )alkyl And ((C ₁ -C ₄ )alkyl)C(O)O((C ₁ -C ₄ )alkyl), wherein each alkyl, alkenyl, alkynyl, haloalkyl, cycloalkyl And a phenyl group, and a heterocyclic group are optionally substituted with one or more substituents independently selected from the group consisting of F, Cl, CN, OH and pendant oxygen; (F) R ¹⁴ , R ¹⁵ , R ¹⁶ , R ¹⁷ , and R ¹⁸ are each independently selected from the group consisting of H, F, Cl, Br, I, CN, NO ₂ , OH, (C ₁ -C) ₄ ) alkyl, (C ₂ -C ₄ )alkenyl, (C ₂ -C ₄ )alkynyl, (C ₁ -C ₄ )haloalkyl, (C ₁ -C ₄ )alkoxy, (C ₁ -C ₄ ) haloalkoxy, (C ₃ -C ₆ )cycloalkyl, (C ₃ -C ₆ )cycloalkoxy, phenyl, and (C ₁ -C ₄ )alkylphenyl, each of which Alkyl, alkenyl, alkynyl, haloalkyl, alkoxy, haloalkoxy, cycloalkyl, cycloalkoxy, cycloalkenyl, and phenyl are optionally one or more independently Substituted from the following substituents: F, Cl, Br, I, CN, NO ₂ and OH; (G) R ¹² and R ¹³ together with (NH)C ^x (N ^x ) form a 4 to 8 Heterocycle, wherein the heterocycle can be optionally one or more a plurality of substituents independently selected from R ¹⁹ are substituted, wherein R ¹⁹ is selected from the group consisting of H, F, Cl, Br, I, CN, OH, (C ₁ -C ₄ ) Alkyl, pendant oxygen, (C ₁ -C ₄ )alkyl, (C ₂ -C ₄ )alkenyl, (C ₂ -C ₄ )alkynyl, (C ₁ -C ₄ )haloalkyl, (C ₁ -C ₄ )alkyl ((C ₃ -C ₆ )cycloalkyl), (C ₁ -C ₄ )alkylphenyl, (C ₁ -C ₄ )alkylheterocyclyl, ((C ₁ - C ₄ )alkyl)C(O)((C ₁ -C ₄ )alkyl), ((C ₁ -C ₄ )alkyl)C(O)O((C ₁ -C ₄ )alkyl), a phenyl group, and a heterocyclic group, wherein each alkyl group, alkenyl group, alkynyl group, haloalkyl group, cycloalkyl group, phenyl group, and heterocyclic group are optionally independently selected from one or more Substituents for the following group are substituted: F, Cl, Br, I, CN, OH, and pendant oxygen; and the N-oxide of the molecule of Formula 1, agriculturally acceptable acid addition salts, salts Derivatives, solvates, crystalline polymorphs, isotopes, resolved stereoisomers, and tautomers.

The molecules of Formula 1 can exist in different geometric or optical isomers or in different tautomeric forms. There may be one or more palmar centers, in which case the molecule of formula 1 may be present as a pure mirror isomer, a mixture of mirror isomers, a pure non-mirror isomer or a non-mirror phase A mixture of isomers. Those skilled in the art will appreciate that one stereoisomer may be more active than other stereoisomers. Individual stereoisomers can be obtained by known selective synthetic procedures, obtained using analytical starting materials by conventional synthetic procedures, or by conventional analytical procedures. There may be double bonds in the molecule, in which case the molecule of formula 1 can exist as a single geometric isomer (cis or trans, E or Z ) or as a geometric isomer (cis and trans) , a mixture of E and Z ). A tautomeric center can exist. The present disclosure encompasses all such isomers, tautomers, and mixtures thereof in all ratios. The structures depicted in the present disclosure are only used to clearly illustrate the geometric form and should not be construed as representing all geometric forms of the molecule.

In another embodiment, R ¹ , R ² , R ⁴ , R ⁵ , R ⁶ , R ⁷ , R ⁸ , R ⁹ , R ¹⁰ , R ¹¹ , R ¹² , R ¹³ and R ¹⁹ are each independently H. . This specific example can be used in combination with other specific examples of R ³ , L , R ¹⁴ , R ¹⁵ , R ¹⁶ , R ¹⁷ and R ¹⁸ .

In another embodiment, R ³ is (C ₁ -C ₄ )haloalkyl or (C ₁ -C ₄ )alkoxy. This specific example may be related to R ¹ , R ² , R ⁴ , R ⁵ , R ⁶ , R ⁷ , R ⁸ , R ⁹ , R ¹⁰ , L , R ¹¹ , R ¹² , R ¹³ , R ¹⁴ , R ¹⁵ , R ^16. Other examples of R ¹⁷ , R ¹⁸ and R ^{19 are} used in combination.

In another embodiment, R ³ is CF ₃ or OCF ₃ . This specific example may be related to R ¹ , R ² , R ⁴ , R ⁵ , R ⁶ , R ⁷ , R ⁸ , R ⁹ , R ¹⁰ , L , R ¹¹ , R ¹² , R ¹³ , R ¹⁴ , R ¹⁵ , R ^16. Other specific examples of R ¹⁷ , R ¹⁸ and R ^{19 are} used in combination.

In another embodiment, L is a bond that links the nitrogen to the carbon on the ring. This specific example may be related to R ¹ , R ² , R ³ , R ⁴ , R ⁵ , R ⁶ , R ⁷ , R ⁸ , R ⁹ , R ¹⁰ , R ¹¹ , R ¹² , R ¹³ , R ¹⁴ , R ¹⁵ , Other specific examples of R ¹⁶ , R ¹⁷ , R ¹⁸ and R ^{19 are} used in combination.

In another embodiment, R ¹⁴ is H, (C ₁ -C ₄ )alkyl, (C ₁ -C ₄ )alkoxy, (C ₁ -C ₄ )haloalkoxy, phenyl, or (C ₁ -C ₄ )alkylphenyl. This specific example may be related to R ¹ , R ² , R ³ , R ⁴ , R ⁵ , R ⁶ , R ⁷ , R ⁸ , R ⁹ , R ¹⁰ , R ¹¹ , R ¹² , R ¹³ , R ¹⁵ , R ¹⁶ , Other specific examples of R ¹⁷ , R ¹⁸ and R ^{19 are} used in combination.

In another embodiment, R ¹⁴ is CH ₃ , CH ₂ CH ₃ , CH ₂ CH ₂ CH ₃ , CH(CH ₃ ) ₂ , OCH ₃ , OCF ₃ , phenyl, or CH ₂ phenyl. This specific example may be related to R ¹ , R ² , R ³ , R ⁴ , R ⁵ , R ⁶ , R ⁷ , R ⁸ , R ⁹ , R ¹⁰ , R ¹¹ , R ¹² , R ¹³ , R ¹⁵ , R ¹⁶ , Other specific examples of R ¹⁷ , R ¹⁸ and R ^{19 are} used in combination.

In another embodiment, R ¹⁵ is H or (C ₁ -C ₄ )alkoxy. This specific example may be related to R ¹ , R ² , R ³ , R ⁴ , R ⁵ , R ⁶ , R ⁷ , R ⁸ , R ⁹ , R ¹⁰ , R ¹¹ , R ¹² , R ¹³ , R ¹⁴ , R ¹⁶ , Other specific examples of R ¹⁷ , R ¹⁸ and R ^{19 are} used in combination.

In another embodiment, R ¹⁵ is OCH ₃ . This specific example may be related to R ¹ , R ² , R ³ , R ⁴ , R ⁵ , R ⁶ , R ⁷ , R ⁸ , R ⁹ , R ¹⁰ , R ¹¹ , R ¹² , R ¹³ , R ¹⁴ , R ¹⁶ , Other specific examples of R ¹⁷ , R ¹⁸ and R ^{19 are} used in combination.

In another embodiment, R ¹⁶ is H, (C ₁ -C ₄ )alkyl, or (C ₁ -C ₄ )alkoxy. This specific example may be related to R ¹ , R ² , R ³ , R ⁴ , R ⁵ , R ⁶ , R ⁷ , R ⁸ , R ⁹ , R ¹⁰ , R ¹¹ , R ¹² , R ¹³ , R ¹⁴ , R ¹⁵ , Other specific examples of R ¹⁷ , R ¹⁸ and R ^{19 are} used in combination.

In another embodiment, R ¹⁶ is CH ₃ or OCH ₃ . This specific example may be related to R ¹ , R ² , R ³ , R ⁴ , R ⁵ , R ⁶ , R ⁷ , R ⁸ , R ⁹ , R ¹⁰ , R ¹¹ , R ¹² , R ¹³ , R ¹⁴ , R ¹⁵ , Other specific examples of R ¹⁷ , R ¹⁸ and R ^{19 are} used in combination.

In another embodiment, R ¹⁷ or R ¹⁸ are each independently H or (C ₁ -C ₄ )alkyl. This specific example may be related to R ¹ , R ² , R ³ , R ⁴ , R ⁵ , R ⁶ , R ⁷ , R ⁸ , R ⁹ , R ¹⁰ , R ¹¹ , R ¹² , R ¹³ , R ¹⁴ , R ¹⁵ , Other specific examples of R ¹⁶ and R ^{19 are} used in combination.

In another embodiment, R ¹⁷ or R ¹⁸ are each independently CH ₃ . This specific example may be related to R ¹ , R ² , R ³ , R ⁴ , R ⁵ , R ⁶ , R ⁷ , R ⁸ , R ⁹ , R ¹⁰ , R ¹¹ , R ¹² , R ¹³ , R ¹⁴ , R ¹⁵ , Other specific examples of R ¹⁶ and R ^{19 are} used in combination.

In another specific example, R ¹² and R ¹³ together with (NH)C ^x (N ^x ) are (1a) (1a) wherein R ¹⁹ is selected from the group consisting of H and side oxygen. This specific example can be combined with R ¹ , R ² , R ³ , R ⁴ , R ⁵ , R ⁶ , R ⁷ , R ⁸ , R ⁹ , R ¹⁰ , R ¹¹ , R ¹⁴ , R ¹⁵ , R ¹⁶ , R ¹⁷ and Other specific examples of R ^{18 are} used in combination.

In another embodiment, (A) R ¹ , R ² , R ³ , R ⁴ , R ⁵ , R ⁷ , R ⁸ , R ⁹ , and R ¹⁰ are each independently selected from H, (C ₁ -C) ₄ ) a haloalkyl group, and (C ₁ -C ₄ ) haloalkoxy; (B) R ⁶ is H; (C) L is a bond which connects the nitrogen to the carbon on the ring; (D) R ¹¹ is H; (E) R ¹² and R ¹³ are (G) or H; (F) R ¹⁴ , R ¹⁵ , R ¹⁶ , R ¹⁷ , and R ¹⁸ are each independently selected from the group consisting of: H (C ₁ -C ₄ )alkyl, (C ₁ -C ₄ )alkoxy, (C ₁ -C ₄ )haloalkoxy, phenyl, and (C ₁ -C ₄ )alkylphenyl; (G) R ¹² and R ¹³ together with (NH)C ^x (N ^x ) are (1a) (1a), wherein R ¹⁹ is selected from H and from the group consisting of oxygen side.

In another embodiment, (A) R ¹ , R ² , R ³ , R ⁴ , R ⁵ , R ⁷ , R ⁸ , R ⁹ , and R ¹⁰ are each independently selected from H, CF ₃ , and OCF. ₃ ; (B) R ⁶ is H; (C) L is a bond which connects nitrogen to carbon on the ring; (D) R ¹¹ is H; (E) R ¹² and R ¹³ are (G) or H; (F) R ¹⁴ , R ¹⁵ , R ¹⁶ , R ¹⁷ , and R ¹⁸ are each independently selected from the group consisting of H, CH ₃ , CH ₂ CH ₃ , CH ₂ CH ₂ CH ₃ , CH (CH ₃ ) ₂ , OCH ₃ , OCF ₃ , phenyl, and CH ₂ phenyl; (G) R ¹² and R ¹³ together with (NH)C ^x (N ^x ) are (1a) (1a), wherein R ¹⁹ is selected from the group consisting of H and side oxygen. Formula 1 preparation

Many of the molecules of Formula 1 can be described as two or more tautomeric forms, such as when R ¹² and R ¹³ are H (flowchart TAU). To simplify the flow diagram, all molecules are depicted as being present as a single tautomer. Any and all actively available tautomers are included within the scope of Formula 1, and it should not be inferred that the molecule is present in its depicted form of tautomer. Flow chart TAU

The molecule of Formula 1 typically has a molecular weight of from about 400 Daltons to about 1200 Daltons. Preparation of anthraquinone 2-2

The oximes disclosed herein can be prepared from the corresponding isocyanates 1-2 wherein R ¹ , R ² , R ³ , R ⁴ , R ⁵ , R ⁶ , R ⁷ , R ⁸ , R ⁹ , R ¹⁰ and L are As previously disclosed. In some instances, isocyanate 1-2 is not isolated, but is produced in situ from a suitable precursor and used directly to prepare a urea. A suitable precursor is amine 1-1 wherein R ¹ , R ² , R ³ , R ⁴ , R ⁵ , R ⁶ , R ⁷ , R ⁸ , R ⁹ , R ¹⁰ and L are as previously disclosed, amines Class 1-1 can be converted to isocyanate by using one of several general reagents such as phosgene, diphosgene, triphosgene or grass chlorinated (flowchart 1, step a) in a mixed solvent system Preferably, the polar aprotic solvent is preferably dichloromethane or diethyl ether and the polar protic solvent is water, in the presence of a base such as sodium bicarbonate or triethylamine at a temperature of from about -10 ° C to about Perform at 50 °C.

Optionally, isocyanate 1-2 can be produced via a Curtius rearrangement of 醯 azide 1-4 , wherein R ¹ , R ² , R ³ , R ⁴ , R ⁵ , R ⁶ , R ^7. R ⁸ , R ⁹ , R ¹⁰ and L are as previously disclosed, and the hydrazine azide can be prepared from the corresponding carboxylic acid 1-3 , wherein R ¹ , R ² , R ³ , R ⁴ , R ⁵ , R ⁶ , R ⁷ , R ⁸ , R ⁹ , R ¹⁰ and L are as previously disclosed. The azide 1-4 (Scheme 1, step b) can be formed by treating the carboxylic acid with ethyl chloroformate and sodium azide in the presence of an amine base such as triethylamine, or diphenylphosphine Azide treatment is formed in the presence of an amine base such as trimethylamine. The azide 1-4 can then undergo a Curtis rearrangement reaction (Scheme 1, step c) to produce the corresponding isocyanate 1-2 . The rearrangement reaction may be in a polar aprotic solvent, preferably in toluene, acetonitrile, or an ether solvent, preferably two depending on the characteristics of the particular nitrogen azide. The alkane or tetrahydrofuran occurs spontaneously at about room temperature (about 22 ° C) or may need to be heated from about 40 ° C to about 100 ° C. Flow chart 1

Due to their reactivity, hydrazine is usually not isolated as a pure substance. Therefore, helium azide is not always fully identified, but isocyanate 1-2 can be produced without the need to identify direct heating. Flow chart 2

Isocyanate 1-2 can be treated directly as hydrazine 2-1 wherein R ¹² and R ¹³ are as previously disclosed, in the presence of from about 0.1 equivalents to about 2 equivalents of an inorganic base such as cesium carbonate or sodium hydride, or In the presence of an amine base such as triethylamine or diisopropylethylamine, or in the presence of an organometallic base such as n-butyllithium, the formation of anthraquinone 2-2 , wherein R ¹¹ is H and R ¹ And R ² , R ³ , R ⁴ , R ⁵ , R ⁶ , R ⁷ , R ⁸ , R ⁹ , R ¹⁰ , L , R ¹² , R ¹³ , R ¹⁴ , R ¹⁵ , R ¹⁶ , R ¹⁷ and R ¹⁸ As previously disclosed (flowchart 2, step a). The reaction can be carried out in a polar aprotic solvent at a temperature of from about 0 ° C to about 100 ° C, preferably from about 20 ° C to about 80 ° C, such as acetonitrile, acetone, toluene, tetrahydrofuran, 1,2-dichloroethane. Or a mixture of dichloromethane. Flow chart 3

Another method of preparation of the anthraquinone 2-2 is described in Scheme 3. Amine 1-1 can be reacted with 4-nitrophenyl chloroformate to form 4-nitrophenylcarbamate 3-1 wherein R ¹¹ is H and R ¹ , R ² , R ³ , R ⁴ , R ⁵ , R ⁶ , R ⁷ , R ⁸ , R ⁹ , R ¹⁰ , L , R ¹² , R ¹³ , R ¹⁴ , R ¹⁵ , R ¹⁶ , R ¹⁷ and R ¹⁸ are as previously disclosed (flow chart 3. Step a). The reaction can be carried out in the presence of a molar amount of amines 1-1 and chloroformate in polar aprotic solvents such as tetrahydrofuran, The alkane or acetonitrile is preferably present at about room temperature in the presence of from about 0.1 equivalents to about 2 equivalents of an inorganic base such as cesium carbonate or potassium carbonate. 4-Nitrophenylcarbamate 2-1 can be filtered from the filtrate and concentrated, or 4-nitrophenylcarbamate 2-1 can be used directly (Scheme 3, step b). Treatment of 4-nitrophenylcarbamate 2-1 with hydrazine 2-1 produces hydrazine 2-2 . The reaction can be carried out in the form of a molar amount of nitrophenyl carbamate 2-1 and hydrazine 3-1 , in a polar aprotic solvent acetonitrile, in an inorganic base such as potassium phosphate, an organic base such as diisopropyl. In the presence of ethylamine, it is preferably carried out at about room temperature. Preparation of amines

The preparation of the amine 1-1 required for the preparation of the molecule of the formula 1 is described in Scheme 4. Halogen-heterocyclic ring 4-1 wherein X is Cl, Br or I and R ¹ , R ² , R ³ , R ⁴ , R ⁵ and R ⁶ are as previously disclosed, with boronate ester 4- 2 wherein R is H or tetramethylethylene, and R ⁷ , R ⁸ , R ⁹ , R ¹⁰ and L are as previously disclosed, and the coupling can be carried out using a palladium catalyst in a base such as sodium hydrogencarbonate, potassium phosphate or In the presence of cesium fluoride, it is carried out in a suitable solvent system such as acetonitrile and water at a temperature of from about 50 ° C to about 120 ° C using conventional or microwave heating to form the amine 1-1 (Scheme 4, Step a). Flow chart 4 Preparation of steroid 2-1

Using a quinone 2-1 as a precursor of the preparation of the molecule of Formula 1, wherein R ¹² and R ¹³ together with (NH)C ^x (N ^x ) are (1a) (1a), wherein R ¹⁹ is H, can be prepared according Motoyoshiya, J. et al., The Tetrahedron 67 (2011) 6927-6933 and Banville, J. et al.'S US 7,494,984, 2009. The process outlined. Using a quinone 2-1 as a precursor of the preparation of the molecule of Formula 1, wherein R ¹² and R ¹³ together with (NH)C ^x (N ^x ) are (1b) (1b), wherein R ¹⁹ is H, can be prepared according to the procedure outlined in Sauter, F. et al., Scientia Pharmaceutica (1996), 64 (3/4), 647-653. Example

The examples are for illustrative purposes and are not to be construed as limiting the disclosure to the specific examples disclosed in the embodiments.

The starting materials, reagents and solvents obtained from commercial sources were used without further purification. Anhydrous solvent was purchased from Sure/SealTM from Aldrich and used in the form received. Melting points were measured on a Thomas Hoover Unimelt capillary melting point apparatus or on an OptiMelt automated melting point system from Stanford Research Systems and uncorrected. Examples using "room temperature" are carried out in a climate control laboratory having a temperature range of from about 20 °C to about 24 °C. The molecular system is displayed with its known name, etc., named after the naming program in ISIS Draw, ChemDraw, or ACD Name Pro. If these programs cannot name a molecule, the molecule is named according to the naming conventions used. ¹ H NMR spectral data is reported in ppm (δ) and at 300, 400, 500 or 600 MHz unless otherwise stated; ¹³ C NMR spectral data is in ppm (δ) and at 75, 100 or The 150 MHz record, as well as the ¹⁹ F NMR spectral data, were recorded in ppm (δ) and at 376 MHz. Example 1 : (1 E )-1-[ Amino( anilino) methylene]-3-[4-[1-[4-( trifluoromethoxy) phenyl]-1 H -1, preparation of 2,4-triazol-3-yl] phenyl] urea (F4) of

4-(4-(Trifluoromethoxy)phenyl)-1 H -1,2,4-triazol-3-yl)benzamide azide (0.25 g) in toluene (12 mL) The stirred solution of 0.698 mmol) was heated to 110 °C for 3 hours. The reaction mixture was cooled to room temperature. The reaction mixture was then cooled to 0 ° C, and 1-phenylindole (0.113 g, 0.837 mmol) and trimethylamine (0.290) dissolved in 1,2-dichloroethane (3 mL) were added dropwise. mL, 2.09 mmol). The reaction mixture was allowed to warm to room temperature and stirred for 24 h. The resulting solid was collected by EtOAc (EtOAc) elute

The following compounds were prepared in a similar manner to the procedure outlined in Example 1 : ( 1E )-1-[ Amino-(2- phenylanilinyl) methylene]-3-[4-[1-[ 4-( trifluoromethoxy) phenyl]-1 H -1,2,4- triazol-3 -yl] phenyl] urea (F1) (1 E )-1-[ Amino-(2- benzylphenylanilinyl) methylene]-3-[4-[1-[4-( trifluoromethoxy) phenyl]-1 H - 1,2,4- triazol-3 -yl] phenyl] urea (F2) (1 E )-1-[ Amino-(2- benzylphenylanilinyl) methylene]-3-[4-[1-[4-( trifluoromethoxy) phenyl]-1 H - 1,2,4- triazol-3 -yl] phenyl] urea (F3) (1 E )-1-[ Amino-(2 -methylanilino) methylene]-3-[4-[1-[4-( trifluoromethoxy) phenyl]-1 H -1 ,2,4- triazol-3 -yl] phenyl] urea (F5) (1 E )-1-[ Amino-(2 -propylanilino) methylene]-3-[4-[1-[4-( trifluoromethoxy) phenyl]-1 H -1 ,2,4- triazol-3 -yl] phenyl] urea (F6) (1 E )-1-[ Amino-(2,5 -dimethylanilino) methylene]-3-[4-[1-[4-( trifluoromethoxy) phenyl]-1 H -1,2,4- triazol-3 -yl] phenyl] urea (F7) (1 E )-1-[ Amino-(2,6 -dimethylanilino) methylene]-3-[4-[1-[4-( trifluoromethoxy) phenyl]-1 H -1,2,4- triazol-3 -yl] phenyl] urea (F8) (1 E )-1-[ Amino-(4 - methoxy- 2- methyl - anilino) methylene]-3-[4-[1-[4-( trifluoromethoxy) benzene ]]-1 H -1,2,4- triazol-3 -yl] phenyl] urea (F9) (1 E )-1-[ Amino-( 2- isopropylanilino) methylene]-3-[4-[1-[4-( trifluoromethoxy) phenyl]-1 H - 1,2,4- triazol-3 -yl] phenyl] urea (F10) Example 2 : (1 E )-1-[ Amino-(2,6 -dimethylanilino) methylene]-3-[4-[1-[4-( trifluoromethoxy) benzene Preparation of thiol-1- H, 1,2,4- triazol-3 -yl] phenyl] urea (F11)

Ammonia (7 N in methanol, 0.500 mL) was added to ( Z )-(( N- (2,6-dimethylphenyl) -N' -((4-()) in methanol (5 mL) 1-(4-(Trifluoromethoxy)phenyl)-1 H -1,2,4-triazol-3-yl)phenyl)amine,carboxylamidyl)amine,carboxamide,yl)sulfonyl) Methyl isobutyrate (0.124 g, 0.203 mmol). The reaction mixture was stirred at room temperature for 16 hours. The reaction mixture was filtered and the filtrate was concentrated. The residue was purified by flash column chromatography eluting elut elut elut Example 3 : General procedure for preparation of N ¹ -phenylethane-1,2- diamine

The N ¹ -phenylethane-1,2-diamine used in the molecular preparation of Formula 1 can be prepared in a similar manner to the procedure outlined in Motoyoshiya, J. et al., Tetrahedron 67 ( 2011 ) 6927-6933. N ¹ - (4- chloro -2 -methylphenyl ) ethane-1,2- diamine (C1) N ¹ - (5- fluoro -2 -methylphenyl ) ethane-1,2- diamine (C2) N ¹ - (2 -ethylphenyl ) ethane-1,2- diamine (C3) N ¹ - (2,4 -dimethylphenyl ) ethane-1,2- diamine (C4) N ¹ -phenylethane-1,2- diamine (C5) N ¹ -3,5- xylene-1,2-diamine ^{(N 1 -Mesitylethane-1,2-diamine} ) (C6) N ¹ - (2 -methoxyphenyl ) ethane-1,2- diamine (C7) N ¹ - (2-( trifluoromethoxy) phenyl ) ethane-1,2- diamine (C8) N ¹ - (3 -methoxyphenyl ) ethane-1,2- diamine (C9) N ¹ - (4 -methoxyphenyl ) ethane-1,2- diamine (C10) Example 4 : General procedure for preparation of 2- amino- imidazoline hydrobromide

The 2-amino-imidazoline hydrobromide salt used in the preparation of the molecule of Formula 1 can be prepared in a similar manner to the procedure outlined in Banville, J. et al., US 7,494,984, 2009 . 1- (4-chloro-2-methylphenyl) -4,5-dihydro -1 H - imidazol-2-amine hydrobromide (C11) 1- (5-fluoro-2-methylphenyl) -4,5-dihydro -1 H - imidazol-2-amine hydrobromide (C12) 1- (2-ethylphenyl) -4,5-dihydro -1 H - imidazol-2-amine hydrobromide (C13) 1- (2,4-dimethyl-phenyl) -4,5-dihydro -1 H - imidazol-2-amine hydrobromide (C14) 1-phenyl-4,5-dihydro -1 H - imidazol-2-amine hydrobromide (C15) 1-3,5-xylenemethyl - 4,5 -dihydro- 1 H - imidazol -2- amine hydrobromide (C16) 1- (2-methoxyphenyl) -4,5-dihydro -1 H - imidazol-2-amine hydrobromide (C17) 1- (2- (trifluoromethoxy) phenyl) -4,5-dihydro -1 H - imidazol-2-amine hydrobromide (C18) 1- (3-methoxyphenyl) -4,5-dihydro -1 H - imidazol-2-amine hydrobromide (C19) 1- (4-methoxyphenyl) -4,5-dihydro -1 H - imidazol-2-amine (C20) Example 5 : ( E )-1-(1- Aryl imidazolidin-2- ylidene)-3-(4-(1-(4-( trifluoromethoxy) phenyl)-1 H -1 General procedure for preparation of 2,4- triazol-3 -yl) phenyl) urea

Add 2-amino-imidazoline hydrobromide (1.0 eq.), potassium phosphate (1.2 eq.) and N,N -diisopropylethylamine (2.0 eq.) to acetonitrile (0.1 M) 4- Nitphenyl (4-(1-(4-(trifluoromethoxy)phenyl)-1 H -1,2,4-triazol-3-yl)phenyl)carbamate (1.0 eq.) . The reaction mixture was stirred at room temperature for 4 hours. The reaction mixture was concentrated under reduced pressure. Purification by flash column chromatography afforded the title compound.

The following compound is to be manner outlined in Example 5 is similar to the embodiment of the preparation process: (E) -1- (1- ( 4- chloro-2-methylphenyl) imidazol-2-ylidene) -3- ( 4-(1-(4-( Trifluoromethoxy) phenyl)-1 H -1,2,4- triazol-3 -yl) phenyl) urea (F12) (E) -1- (1- (5- fluoro-2-methylphenyl) imidazol-2-ylidene) -3- (4- (1- (4- (trifluoromethoxy) phenyl )-1 H -1,2,4- triazol-3 -yl) phenyl) urea (F13) (E) -1- (1- (2- ethylphenyl) imidazole-2-ylidene) -3- (4- (1- (4- (trifluoromethoxy) phenyl) -1 H -1,2,4- triazol-3 -yl) phenyl) urea (F14) ( E )-1-(1-3,5-xylenemethylimidazolidine -2- ylidene)-3-(4-(1-(4-( trifluoromethoxy) phenyl)-1 H -1,2,4- triazol-3 -yl) phenyl) urea (F15) (E) -1- (1- phenyl-imidazol-2-ylidene) -3- (4- (1- (4- (trifluoromethoxy) phenyl) -1 H -1,2,4 - triazol-3-yl) phenyl) urea (F16) ( E )-1-(1-3,5-xylenemethylimidazolidine -2- ylidene)-3-(4-(1-(4-( trifluoromethoxy) phenyl)-1 H -1,2,4- triazol-3 -yl) phenyl) urea (F17) (E) -1- (1- (2- methoxyphenyl) imidazol-2-ylidene) -3- (4- (1- (4- (trifluoromethoxy) phenyl) -1 H -1,2,4- triazol-3 -yl) phenyl) urea (F18) (E) -1- (4- (1- (4- ( trifluoromethoxy) phenyl) -1 H -1,2,4- triazol-3-yl) phenyl) -3- (1 - (2- (trifluoromethoxy) phenyl) imidazol-2-ylidene) urea (F19) (E) -1- (1- (3- methoxyphenyl) imidazole-2-ylidene) -3- (4- (1- (4- (trifluoromethoxy) phenyl) -1 H -1,2,4- triazol-3 -yl) phenyl) urea (F20) (E) -1- (1- (4- methoxyphenyl) imidazol-2-ylidene) -3- (4- (1- (4- (trifluoromethoxy) phenyl) -1 H -1,2,4- triazol-3 -yl) phenyl) urea (F21)

The following predicted molecules can be prepared according to the above disclosed flow chart or examples: Table 1. Structure and preparation method of P series molecules * Can be prepared according to the example number

It is understood that some reagents and reaction conditions may be incompatible with certain functionalities of certain molecules of Formula 1 or certain molecules used in the preparation of certain molecules of Formula 1. In such cases, it may be necessary to use standard protection and deprotection agreements that are widely reported in the literature and are familiar to those skilled in the art. Moreover, in some cases, it may be necessary to perform further synthetic steps not described herein to accomplish the synthesis of the desired molecule. Those skilled in the art will also appreciate that the synthesis of the desired molecule can be accomplished by performing steps of some synthetic routes in a different order than described. Those skilled in the art will also appreciate that it is possible to perform standard conversion or substitution reactions on a desired molecule to introduce or modify a substituent. Bioanalytical method

This article includes the following for Beet Armyworm (Spoonoptera exigua , Cabbage Looper ( Trichoplusia ni ), and yellow fever mosquito (Aedes aegypti) ( Aedes aegypti ) bioanalysis, because of its loss, etc. In addition, beet armyworm and cabbage beetle are two good indicator species of broad-spectrum chewing pests. In addition, Green Peach Aphid) is a good indicator species for a wide range of feeding insect pests. The results of four indicator species together with yellow fever mosquitoes show that the molecules of formula 1 control arthropods, mollusks, and circles. . phylum shaped versatility of pests (Drewes et al.) Example a: Spodoptera exigua (beet armyworm) (beet armyworm (Spodoptera exigua), LAPHEG) ( "BAW") and cabbage looper ( Cabbage Looper) (cabbage looper (Trichoplusia ni), TRIPNI) ( "CL") of bioanalytical

Beet armyworm is economically economical for alfalfa, asparagus, beets, citrus, corn, cotton, onions, peas, peppers, potatoes, soybeans, sugar beets, sunflowers, tobacco and tomatoes, and other crops. Pests of serious concern. It is native to Southeast Asia but is now available in Africa, Australia, Japan, North America and Southern Europe. Larvae can be eaten on a large scale, causing devastating crop losses. It is known to be resistant to several insecticides.

Brassica chinensis is a serious pest that can be found all over the world. It attacks alfalfa, beans, beets, broccoli, kale, cabbage, cantaloupe, broccoli, celery, collard, cotton, cucumber, eggplant, kale, lettuce, melon, mustard, Parsley, peas, pepper, potato, soybean, spinach, pumpkin, tomato, turnip and watermelon, and other crops. This species is very destructive to plants due to its greedy appetite. Larvae eat three times their weight every day. A large amount of sticky, moist feces will appear in the feeding place, which will lead to higher disease stress, which will cause secondary problems in the plants. It is known to be resistant to several insecticides.

Therefore, based on the above factors, the control of such pests is important. Moreover, molecules that control these pests known as chewing pests (BAW and CL) can be used to control other pests of chewing plants.

Certain of the molecules disclosed in this document use the procedures described in the following examples to test their ability to combat BAW and CL. For reporting of results, use the “ BAW & CL Rating Table ” (see the table section). Biological analysis of BAW

The BAW bioassay was performed using a 128-well food plate analysis. Place one to five second-instar BAW larvae in each well (3 ml) of the food tray. This food tray has been filled with 1 ml of artificial food beforehand, and 50 μg/cm ² of test molecules have been applied (dissolved in 50). 90 μL of a mixture of acetone and water (to each of the eight wells), then allowed to dry. The trays were covered with a clear self-adhesive cover, perforated to allow gas exchange, and held at 25 ° C, 14:10 light-dark for five to seven days. The percentage of larval mortality per well was recorded; the activity in the eight wells was then averaged. The results are shown in the table entitled " Table ABC : Bioanalytical Results " (see table section). Biological analysis of CL

The biological analysis of CL was performed using a 128-well food plate analysis. Place one to five second-instar CL larvae in each well (3 ml) of the food tray. This food tray has been filled with 1 ml of artificial food beforehand, and 50 μg/cm ² of test molecules have been applied (dissolved in 50 90 μL of a mixture of acetone and water (to each of the eight wells), then allowed to dry. The trays were covered with a clear self-adhesive covering, open to allow gas exchange, and held at 25 ° C, 14:10 light-dark for five to seven days. The percentage of larval mortality per well was recorded; the activity in the eight wells was then averaged. The results are shown in the table entitled " Table ABC : Bioanalytical Results " (see table section). Example B: Analysis of the yellow fever mosquito (Aedes aegypti (Aedes aegypti, AEDSAE) ( " YFM"))) for a creature.

YFM likes to bite humans during the day and is most often found in or near human settlements. YFM is a medium for the transmission of several diseases. YFM is a mosquito that can transmit dengue and yellow fever viruses. Yellow fever is the second most dangerous mosquito-borne disease, second only to malaria. Yellow fever is an acute viral hemorrhagic disease, and up to 50% of serious patients who have not received treatment will die from yellow fever. It is estimated that there will be 200,000 cases of yellow fever worldwide each year, resulting in 30,000 deaths. Dengue fever is an unpleasant viral disease; it is sometimes called "joint pain fever" or "heart pain fever" because it produces severe pain. Dengue fever kills about 20,000 people each year. Therefore, the above factors controlling this pest are quite important. In addition, the control of this known fungus pest (YFM) molecule can be used to control diseased humans and other ingestive pests in animals.

Certain of the molecules disclosed in this document use the procedures described in the following paragraphs to test their ability to combat YFM. For the reporting of results, use the “ YFM Rating Table ” (see the table section).

A master disk containing 400 μg of molecule dissolved in 100 μL of dimethyl sulfoxide (DMSO) (equivalent to 4000 ppm solution) was used. The master of the combined molecule contains 15 μL per well. In this dish, 135 μL of a 90:10 water/acetone mixture was added to each well. The robot (Biomek® NXP Laboratory Automation Workstation) setup program allocates 15 μL of aspirate from the master to an empty 96-well tray (“child” tray). 6 reps ("sub" disk) per master. Immediately after the "child" disk is produced, it is infected by YFM larvae.

On the day before the dish was treated, the mosquito eggs were placed in Millipore water containing liver powder and incubation was started (4 g. to 400 mL). After the "child" disk was prepared using a robot, the sub-plate was infected with 220 μL of liver powder/mosquito larvae mixture (about 1 day old larva). After the disc is infected by mosquito larvae, the disc is covered with a non-volatile cover to reduce drying. The plate was maintained at room temperature for 3 days and then fractionated. After 3 days, each well was observed and scored according to mortality. The results are shown in the table entitled " Table ABC : Bioanalytical Results " (see table section). Agriculturally acceptable acid addition salts, salt derivatives, solvates, ester derivatives, polymorphs, isotopes and radionuclides

The molecule of formula 1 can be formulated into an agriculturally acceptable acid addition salt. As a non-limiting example, the amine functional group can be combined with hydrochloric acid, hydrobromic acid, sulfuric acid, phosphoric acid, acetic acid, benzoic acid, citric acid, malonic acid, salicylic acid, malic acid, fumaric acid, oxalic acid, succinic acid, Tartaric acid, lactic acid, gluconic acid, ascorbic acid, maleic acid, aspartic acid, benzenesulfonic acid, methanesulfonic acid, ethanesulfonic acid, hydroxamic acid, and isethionate form salts. Additionally, as a non-limiting example, acid functional groups can form salts, including those derived from alkali or alkaline earth metals and derived from ammonia and amines. Preferred examples of the cation may include sodium, potassium, and magnesium.

The molecule of formula 1 can be formulated as a salt derivative. As a non-limiting example, a salt derivative can be prepared by contacting a free base with a sufficient amount of the desired acid to produce a salt. The free base can be regenerated by treating the salt with a suitable aqueous dilute solution such as dilute sodium hydroxide, potassium carbonate, ammonia, and aqueous sodium bicarbonate. As an example in many cases, an insecticide such as 2,4-D can be more water soluble by converting it to its dimethylamine salt.

The molecule of Formula 1 can be formulated with a solvent to form a stable complex such that the complex remains intact after removal of the solvent that is not mismatched. Such complexes are often referred to as "solvates." However, it is preferred to form a stable hydrate with water as a solvent.

The molecule of formula 1 containing an acid function can be prepared as an ester derivative. These ester derivatives can then be applied in a manner similar to the application of the molecules disclosed in this document.

The molecule of Formula 1 can be prepared as various crystalline polymorphs. Polymorphism is important in the development of agrochemicals because of the different physical properties and biological potencies of different crystalline polymorphs or structures of the same molecule.

The molecule of formula 1 can be made with different isotopes. Of particular importance are molecules having ² H (also known as hydrazine) or 3H (also known as hydrazine) in place of ¹ H. Molecules of Formula 1 can be made from different radionuclides. Of particular importance are molecules having ¹⁴ C (also known as radiocarbon). Formula 1 with hydrazine, hydrazine, or ¹⁴ C substitution can be used in biological research to track chemical and physical processes and half-life studies, as well as MoA studies. combination

In another embodiment of the invention, the molecule of Formula 1 can be used in combination with one or more active ingredients (such as in the form of a mixture of ingredients, or simultaneously or sequentially).

In another embodiment of the invention, the molecule of Formula 1 can be used in combination with one or more active ingredients (such as in the form of a mixture of ingredients, or simultaneously or sequentially), each of which has Formula 1 The mode of action of the molecules ("MoA") is the same, similar but more likely to be - different.

In another embodiment, the molecule of Formula 1 can be used in combination with one or more molecules (such as in the form of a mixture of compounds, or simultaneously or sequentially) having killing, algicidal, and egg killing. , bactericidal, fungicidal, herbicidal, insecticidal, molluscicidal, nematicidal, rodent and/or virucidal properties.

In another embodiment, the molecule of Formula 1 can be used in combination with one or more molecules (such as in the form of a mixture of compositions, or simultaneously or sequentially), the one or more molecules being antifeedants, bird repellents, chemical sterilization Agents, herbicide safeners, insecticides, insect repellents, mammalian agents, mating interferers, plant activators, plant growth regulators and/or synergists.

In another embodiment, the molecule of Formula 1 can be used in combination with one or more biological insecticides (such as in the form of a mixture of ingredients, or simultaneously or sequentially).

In another embodiment, the combination of the molecule of Formula 1 with the pesticidal composition of the active ingredient can be used in a wide range of weight ratios. For example, the weight ratio of the two component mixture, the molecular weight of the formula 1 to the active ingredient, can be used in the weight ratio in Table B. Generally, however, a weight ratio of less than about 10:1 to about 1:10 is preferred. It is also preferred to use a mixture comprising one, three, four, six, seven, or more components comprising a molecule of formula 1 and an additional two or three active ingredients.

The weight ratio of the molecule of formula 1 to an active ingredient can be described as X:Y ; wherein X is part by weight of the molecule of formula 1 and Y is part by weight of the active ingredient. The value of X parts by weight is in the range of 0 < X ≤ 100 and the value of Y parts by weight is 0 < Y ≤ 100, and is shown in Table C by a graph. As a non-limiting example, the weight ratio of the molecule of Formula 1 to an active ingredient can range from 20:1.

The weight ratio range of the molecule of formula 1 to an active ingredient can be described as X ₁ : Y ₁ to X ₂ : Y ₂ , wherein X and Y are as defined above.

In one embodiment, the weight ratio may range from X ₁ : Y ₁ to X ₂ : Y ₂ , where X ₁ > Y ₁ and X ₂ < Y ₂ . As a non-limiting example, the weight ratio of the molecule of Formula 1 to an active ingredient can range between about 3:1 and about 1:3, inclusive.

In another embodiment, the weight ratio may range from X ₁ : Y ₁ to X ₂ : Y ₂ , where X ₁ > Y ₁ and X ₂ > Y ₂ . As a non-limiting example, the weight ratio of the molecule of Formula 1 to an active ingredient can range between about 15:1 and about 3:1, inclusive.

In another embodiment, the weight ratio may range from X ₁ : Y ₁ to X ₂ : Y ₂ , where X ₁ < Y ₁ and X ₂ < Y ₂ . As a non-limiting example, the weight ratio of the molecule of Formula 1 to an active ingredient can range between about 1:3 and about 1:20, inclusive.

As shown in Tables B and C, certain weight ratios of the molecule of Formula 1 to an active ingredient are conceivable as synergistic. Formulation

Insecticides are often not suitable for use in pure form. It is often desirable to add other materials so that the pesticide can be used in a desired concentration and in a suitable form that allows for convenient application, handling, transport, storage, and maximum insecticidal activity. Therefore, the insecticide is formulated into, for example, a bait, a concentrated emulsion, a powder, an emulsifiable concentrate, a fumigant, a gel, a granule, a microcapsule, a seed treatment, a suspension concentrate, a suspoemulsion, an ingot. Agent, water-soluble liquid agent, water-dispersible granule or dry flowable agent, wettable powder and ultra-low volume solution.

Insecticides are most often applied in the form of aqueous suspensions or emulsions prepared from concentrated formulations of such insecticides. Such water soluble, water suspendable or emulsifiable formulations are solids, commonly referred to as wettable powders, water dispersible granules, or liquids, commonly referred to as emulsifiable concentrates or aqueous suspensions. A wettable powder which can be compacted to form water dispersible granules comprising an intimate mixture of an insecticide, a carrier and a surfactant. The concentration of the pesticide is usually from about 10% by weight to about 90% by weight. The carrier is typically selected from the group consisting of attapulgite clay, montmorillonite clay, diatomaceous earth or purified citrate. An effective surfactant comprising from about 0.5% to about 10% of a wettable powder, found in sulfonated lignin, condensed naphthalene sulfonate, naphthalene sulfonate, alkyl benzene sulfonate, alkyl sulfate, and nonionic A surfactant such as an ethylene oxide adduct of an alkyl phenol.

The emulsifiable concentrate of the insecticide comprises a pesticidal agent dissolved in a suitable concentration in the carrier, such as from about 50 to about 500 grams per liter of liquid, the carrier being a water-miscible solvent or a water-immiscible organic solvent. And a mixture of emulsifiers. Suitable organic solvents include aromatics, especially xylenes and petroleum fractions, especially high boiling naphthalene and olefin fractions of petroleum, such as heavy aromatic petroleum brains. Other organic solvents such as a terpene solvent including a rosin derivative, an aliphatic ketone such as cyclohexanone, and a complex alcohol such as 2-ethoxyethanol may also be used. Suitable emulsifiers for the emulsifiable concentrate are selected from the customary anionic and nonionic surfactants.

The aqueous suspension comprises a suspension of a water-insoluble pesticide dispersed in an aqueous carrier at a concentration ranging from about 5% by weight to about 50% by weight. The suspension is prepared by finely grinding the insecticide and vigorously mixing it into a carrier comprising water and a surfactant. Additives such as inorganic salts and synthetic or natural gums may also be added to increase the density and viscosity of the aqueous carrier. It is generally most effective to simultaneously grind and mix the pesticide by preparing and homogenizing the aqueous mixture in an instrument such as a sand mill, a ball mill or a piston type homogenizer. The insecticide in the suspension can be microencapsulated in a plastic polymer.

The oil dispersion (OD) comprises a suspension of a non-organic solvent-soluble insecticide which is finely dispersed in a mixture of an organic solvent and an emulsifier at a concentration ranging from about 2% by weight to about 50% by weight. One or more insecticides can be dissolved in an organic solvent. Suitable organic solvents include aromatics, especially xylenes and petroleum fractions, especially high boiling naphthalene and olefin fractions of petroleum, such as heavy aromatic petroleum brains. Other organic solvents may also be used, including vegetable oils, seed oils, and esters of vegetable oils and seed oils. Suitable emulsifiers for the oil dispersion are selected from the customary anionic and nonionic surfactants. A thickener or gelling agent is added to the oil dispersion formulation to alter the rheology or flow properties of the liquid and to prevent separation and precipitation of dispersed particles or droplets.

The insecticides can also be applied in the form of a particulate composition which is especially suitable for application to the soil. The particulate composition typically contains from about 0.5% to about 10% by weight of the pesticide dispersed in the carrier, the carrier comprising clay or the like. Such compositions are typically prepared by dissolving the pesticide in a suitable solvent and applying it to a particulate carrier which has been preformed to a suitable particle size, from about 0.5 mm to about Within 3mm range. These compositions may also be formulated by forming the carrier and the molecule into a dough or paste, then crushing and drying to obtain the desired particle size. Another type of particle is water emulsifiable particles (EG). It is a formulation consisting of particles applied as an oil-in-water emulsion of a conventional active ingredient, dissolved or diluted in an organic solvent after being disintegrated or dissolved in water. The water emulsifiable granules contain one or more active ingredients dissolved or diluted in a suitable organic solvent which are absorbed by the polymeric shell or some other type of soluble or insoluble matrix.

Dust containing insecticides are prepared by intimately mixing the pesticide in powder form with a suitable dusty agricultural vehicle such as kaolin clay, ground volcanic rock and the like. The dusting agent may suitably contain from about 1% to about 10% of the pesticide. The dust can be applied as a seed dressing or applied to the blade by a dust blower.

It is also possible to apply the insecticide in the form of a solution in a suitable organic solvent, typically a petroleum such as a spray oil, which is widely used in agrochemicals.

The insecticide can also be applied in the form of an aerosol composition. In such compositions, the pesticide is dissolved or dispersed in a carrier which is a pressurized propellant mixture. The aerosol composition is packaged in a container that is sprayed from the container via an atomizing valve.

When the pesticide is mixed with food or an attractant or both, an insecticide bait is formed. When the pest eats the bait, it also ingests the pesticide. The bait can be in the form of granules, gels, flowable powders, liquids or solids. The bait can be used to hide the pests.

The fumigant is an insecticide having a relatively high vapor pressure and thus can be present in a gas form at a concentration sufficient to kill the pest in the soil or sealed space. The toxicity of the fumigant is proportional to its concentration and exposure time. It is characterized by having good diffusion ability and acting by infiltrating into the respiratory system of the pest or by absorption from the epidermis of the pest. The fumigant is applied to control the stored product pests under the gas proof sheet in an airtight room or building or in a specialized chamber.

The insecticide can be microencapsulated by suspending the pesticide particles or droplets in various types of plastic polymers. Microcapsules of various sizes, solubilities, wall thicknesses, and permeability can be formed by altering the chemical nature of the polymer or by varying the factors in processing. These factors control the rate of release of the active ingredient, which in turn affects the residual performance, speed of action and odor of the product. The microcapsules can be formulated as suspension concentrates or water dispersible granules.

The oil solution concentrate is prepared by dissolving the insecticide in a solvent which will leave the pesticide in solution. The insecticide oil solution generally provides faster knockdown and killing of pests than other formulations because the solvent itself has an insecticidal action and the dissolved body is covered with a waxy cover to increase the rate of insecticide uptake. Other advantages of the oil solution include better storage stability, better crack penetration, and better greasy surface adhesion.

Another specific example is an oil-in-water emulsion, wherein the emulsion comprises oily pellets, each of which is provided with a layered liquid crystal coating and dispersed in an aqueous phase, wherein each of the oily pellets comprises at least one of An agriculturally active molecule, individually coated with a monolayer or oligo layer, comprising: (1) at least one nonionic lipophilic surfactant, and (2) at least one nonionic hydrophilic interface An active agent, and (3) at least one ionic surfactant, wherein the pellets have an average particle size of less than 800 nanometers. Other formulation components

In general, when the molecule disclosed in Formula 1 is used in a formulation, the formulation may also contain other components. Such components include, but are not limited to, (a list of non-exhaustive and non-exclusive list) humectants, spreaders, adhesives, penetrants, buffers, chelating agents, float lowering agents, compatibilizers, Defoamer, detergent and emulsifier. Some components are now explained.

The wetting agent is a cerium material that, when added to a liquid, increases the spreading or penetration of the liquid by reducing the interfacial tension between the liquid and its spreading surface. Wetting agents are used in two main functions in agrochemical formulations: increasing the rate of wetting of the powder in water during processing and manufacturing to produce a soluble liquid concentrate or suspension concentrate; and in the product with water in a spray can The wetting time of the wettable powder is lowered during the middle mixing, and the penetration of water into the water-dispersible particles is improved. Examples of wetting agents for use in wettable powders, suspension concentrates and water dispersible granule formulations are: sodium lauryl sulfate; sodium dioctyl sulfosuccinate; alkyl phenol ethoxylates; Alcohol ethoxylate.

The dispersant is a substance that adsorbs onto the surface of the particles, helps to maintain the dispersed state of the particles, and prevents the particles from re-aggregating. The dispersant is added to the agrochemical formulation to aid dispersion and suspension during manufacture and to help ensure that the particles are redispersed into the water in the spray can. It is widely used in wettable powders, suspension concentrates and water-dispersible granules. The surfactant used as a dispersing agent has the ability to adhere strongly to the surface of the particles and to provide charge or space barriers for particle re-aggregation. The most commonly used surfactants are anionic, nonionic or a mixture of these two types. For wettable powder formulations, the most commonly used dispersant is sodium lignosulfonate. For suspension concentrates, polyelectrolytes, such as sodium-naphthalenesulfonate-formaldehyde-concentrates, are used to obtain excellent adsorption and stabilization. Tristyrylphenol ethoxylate phosphate is also used. Nonionics, such as alkyl aryl ethylene oxide concentrates and EO-PO block copolymers, are sometimes combined with anionics as a dispersing agent for suspending concentrates. In recent years, new types of very high molecular weight polymer surfactants have been developed as dispersants. These have extremely long hydrophobic "main chain" and a large number of oxyethylene chains, which form the "tooth" of the "comb" surfactant. These high molecular weight polymers provide excellent long term stability to the suspension concentrate because the hydrophobic backbone has many anchor points to the particle surface. Examples of dispersants for use in agrochemical formulations are: sodium lignosulfonate; sodium naphthalenesulfonate formaldehyde concentrate; tristyrylphenol-ethoxylate-phosphoric acid ester; aliphatic alcohol ethoxylate; alkyl Ethoxylate; EO-PO block copolymer; and graft copolymer.

An emulsifier is a substance that stabilizes a suspension of one liquid phase in another liquid phase. In the absence of an emulsifier, the two liquids separate into two immiscible liquid phases. The most commonly used emulsifier blends contain an alkyl phenol or an aliphatic alcohol having 12 or more ethylene oxide units, and an oil soluble calcium salt of dodecyl benzene sulfonic acid. A hydrophilic-lipophilic balance ("HLB") value ranging from about 8 to about 18 will generally provide a well-stabilized emulsion. Emulsion stability can sometimes be improved by the addition of a small amount of EO-PO block copolymer surfactant.

Solubilizers are surfactants that form micelles in water at concentrations above the critical cell concentration. The micelles are then capable of dissolving or solubilizing the water insoluble material in the hydrophobic portion of the micelle. The types of surfactants commonly used for dissolution are nonionic, sorbitan monooleate, sorbitan monooleate ethoxylate and methyl oleate.

Surfactants are sometimes used alone or in combination with other additives, such as mineral or vegetable oils as adjuvants, to improve the bioavailability of the pesticide to the target. The type of surfactant used for bio-enhancement is generally dependent on the nature of the pesticide and the mode of action. However, they are typically nonionics such as: alkyl ethoxylates; linear aliphatic alcohol ethoxylates; and aliphatic amine ethoxylates.

The carrier or diluent in the agricultural formulation is the substance added to the pesticide to give the desired strength product. The carrier is usually a material having a higher absorption capacity, and the diluent is usually a substance having a lower absorption capacity. Carriers and diluents are used in the formulation of dusts, wettable powders, granules and water-dispersible granules.

Organic solvents are mainly used in the formulation of emulsifiable concentrates, oil-in-water emulsions, suspoemulsions, oil dispersions and ultra-low volume formulations, and to a lesser extent for particle formulations. Sometimes a mixture of solvents is used. The solvent of the first major group is an aliphatic paraffinic oil such as kerosene or refined paraffin. The second major group (and most commonly) comprises an aromatic solvent such as xylene and a fraction of higher molecular weight C9 and C10 aromatic solvents. When the formulation is emulsified into water, the chlorinated hydrocarbon is used as a cosolvent to prevent crystallization of the pesticide. Alcohols are sometimes used as cosolvents to enhance solvent efficacy. Other solvents may include vegetable oils, seed oils, and esters of vegetable oils and seed oils.

Thickeners or gelling agents are mainly used in suspension concentrates, oil dispersions, emulsions and suspoemulsion formulations to alter the rheology or flow properties of the liquid and to prevent separation and precipitation of dispersed particles or droplets. Thickeners, gelling agents and anti-settling agents generally fall into two categories, namely water-insoluble particles and water-soluble polymers. Clay and cerium oxide can be used to make suspension concentrates and oil dispersion formulations. Examples of such types of materials include, but are not limited to, montmorillonite, bentonite, magnesium aluminum silicate, and magnesium aluminum sepiolite. Water-soluble polysaccharides formulated with water-based suspension concentrates have been used as thickening-gelling agents for many years. The most commonly used polysaccharide types are natural extracts of seeds and seaweed or synthetic derivatives of cellulose. Examples of such materials include, but are not limited to, guar gum; locust bean gum; carrageenan; alginate; methylcellulose; sodium carboxymethylcellulose (SCMC); and hydroxyethylcellulose ( HEC). Other types of anti-settling agents are based on modified starch, polyacrylate, polyvinyl alcohol and polyethylene oxide. Another good anti-settling agent is Sanxianjiao.

Microorganisms can lead to corruption in blended products. Therefore, preservatives are used to eliminate or reduce the effects of them. Examples of such agents include, but are not limited to, propionic acid and its sodium salt; sorbic acid and its sodium or potassium salt; benzoic acid and its sodium salt; sodium p-hydroxybenzoate; methylparaben; and 1,2 - Benzoisothiazolin-3-one (BIT).

The presence of a surfactant often causes the water-based formulation to foam during the mixing operation when it is manufactured and applied via a spray tank. To reduce the tendency to foam, defoamers are typically added during the manufacturing stage or prior to filling into the bottle. There are generally two types of defoamers, namely polyoxynium and non-polyoxygen. The polyoxyxylene is typically an aqueous emulsion of dimethyl polyoxane, while the non-polyoxygen defoamer is a water insoluble oil such as octanol and decyl alcohol, or cerium oxide. In both cases, the function of the antifoaming agent is to replace the surfactant from the air-water interface.

"Green" preparations (eg, adjuvants, surfactants, solvents) can reduce the overall environmental footprint of crop protection formulations. Green reagents are biodegradable and are typically derived from natural and/or sustainable sources, such as plant and animal sources. Specific examples are: vegetable oils, seed oils and their esters, and alkoxylated alkyl polyglucosides. Application

The molecule of Formula 1 can be applied to any location. Specific locations for the application of such molecules include alfalfa, almonds, apples, barley, beans, canola, corn, cotton, cruciferous plants, flowers, feed species (Rye Grass, Sudan Grass, Tall Fescue, Kentucky Blue Grass and Clover, Fruit, Lettuce, Oats, Oilseed Crops, Oranges, Peanuts, Pears, Peppers, Potatoes, Rice, Sorghum, Soy, Strawberries , sugar cane, sugar beet, sunflower, tobacco, tomato, wheat (for example, Hard Red Winter Wheat, Soft Red Winter Wheat, White Winter Wheat, Hard Red Spring Wheat) (Hard Red Spring Wheat) and Durum Spring Wheat, and where other valuable crops are grown or where their seeds are to be planted.

Molecules of Formula 1 can also be applied to plants, such as where the crop is grown, and areas where the level of pests that cause commercial loss of such plants is low (even without actual presence). The application of such molecules at this location is advantageous for plants grown in this location. Such benefits may include, but are not limited to, assisting plants in growing better root systems; assisting plants to better withstand stress growth conditions; improving plant health; improving plant yield (eg, increasing biomass and/or increasing the amount of valuable ingredients). Improving plant vigor (eg, improving plant growth and/or greener leaves); improving plant quality (eg, improving the content or composition of certain ingredients); and improving plant tolerance to abiotic and/or biotic stresses.

When planting various plants, the compound of Formula 1 can be administered with ammonium sulfate as this provides additional benefits.

Molecules of Formula 1 can be applied to genetically engineer to express specific traits, such as Bacillus thuringiensis (for example, Cry1Ab, Cry1Ac, Cry1Fa, Cry1A.105, Cry2Ab, Vip3A, mCry3A, Cry3Ab, Cry3Bb, Cry34Ab1/Cry35Ab1) ), other insecticidal toxins, or such plants that exhibit herbicide tolerance, or "stacked" that exhibit insecticidal toxins, herbicide tolerance, nutritional fortification, or any other beneficial trait "On, in or around the plant of a foreign gene."

Molecules of Formula 1 can be applied to the leaves and/or fruit portions of the plant to be controlled. These molecules will come into direct contact with the pests, or the pests will ingest these molecules when they consume the plants or extract juice or other nutrients from the plant.

Molecules of Formula 1 can also be applied to the soil, and when applied in this manner, pests of edible roots and stems can be controlled. The roots can absorb these molecules and thereby deliver them to the leaf portion of the plant to control the pests that feed on the ground and chew.

Pests located in another part of the plant can be controlled by applying a systemic movement of the insecticide in the plant by applying one molecule of the formula in a different part of the plant (for example by spraying a locus). For example, controlling leaf-feeding insects can be achieved by drip irrigation or strip application, by treating the soil with, for example, soiling before or after planting, or by treating the plant seeds before planting.

The molecule of Formula 1 can be administered with the bait. In general, in the case of bait, the bait is placed on the ground and termites can be in contact with and/or attracted to the bait. The bait can also be applied to the building surface (horizontal, vertical or sloping surface) where ants, termites, cockroaches and flies are in contact with and/or attracted to the bait.

The molecule of Formula 1 can be encapsulated within a capsule or placed on the surface of a capsule. Capsules can range in size from nanometer size (about 100-900 nm in diameter) to micron size (about 10-900 microns in diameter).

The molecule of formula 1 can be applied to the eggs of pests. Since some pest eggs have unique capabilities against certain insecticides, it may be necessary to repeatedly apply these molecules to control emerging larvae.

Molecules of Formula 1 can be administered as a seed treatment. Seeds of all types of seeds that will germinate may be seeded, including seeds of plants that have been genetically modified to exhibit a particular trait. Representative examples include invertebrate pests, such as Bacillus thuringiensis , which exhibit protein toxicity or other insecticidal toxins, exhibit herbicide tolerance, such as "Roundup Ready" seeds, or have the performance of insecticidal toxins. A "stacked" foreign gene with herbicide tolerance, nutrient augmentation, drought tolerance or any other beneficial property. In addition, the use of seed treatment of the formula 1 molecule further enhances the ability of the plant to withstand harsh growth conditions. This results in a healthier, more vigorous plant that can result in higher yields during harvest. In general, it is expected that such molecules will provide good benefits from about 1 gram to about 500 grams per 100,000 seeds, and it is expected that an amount of from about 10 grams to about 100 grams per 100,000 seeds will provide better benefits, and it is expected that each An amount of from about 25 grams to about 75 grams of 100,000 seeds will provide even better benefits.

The molecule of Formula 1 can be used with one or more active ingredients in the field of soil improvement.

Molecules of Formula 1 can be used to control parasites and ectoparasites in the field of veterinary medicine or in the field of non-human animal feeding. Such molecules can be administered, for example, by oral administration, for example, in the form of tablets, capsules, beverages, granules, by coating the skin in, for example, soaking, spraying, pouring, dispensing, and dusting, and by, for example, Administration by parenteral administration in the form of an injection.

Molecules of Formula 1 can also be advantageously used in livestock breeding, such as cattle, chickens, geese, goats, pigs, sheep, and turkeys. They can also be advantageously used for pets such as horses, dogs and cats. The specific pests to be controlled will be flies, fleas and ticks that can cause trouble to these animals. Suitable formulations are administered orally with the drinking water or feed. Suitable dosages and formulations will depend on the species.

Molecules of Formula 1 can also be used to control parasites, particularly parasites in the gut of animals listed above.

Formula 1 molecules can also be used in the treatment of human health care. Such methods include, but are not limited to, oral administration in the form of, for example, lozenges, capsules, beverages, granules, and administration by the skin.

Molecules of Formula 1 can also be applied to invasive pests. Pests around the world are migrating to new environments (for this pest) and have since become new invasive species in this new environment. These molecules can also be used in these new invasive species to control them in this new environment.

Prior to the use or commercial sale of pesticides, such pesticides undergo a lengthy evaluation process in accordance with various government regulations (local, regional, state, national, and international). A large amount of data is required to be specified by the regulatory body and must be handled by the product registrant or a third party acting on behalf of the product registrar, typically using a computer connected to the World Wide Web, via data generation and submission. These government agencies then review the data and, if the conclusion is judged to be safe, provide a potential user or vendor product registration approval certificate. Thereafter, the user or vendor may use or sell the pesticide in areas where the product is registered and supported.

The molecule of Formula 1 can be tested to determine its efficacy against pests. Alternatively, the molecule of Formula 1 can be combined with another active ingredient to form a pesticidal composition which is then tested using conventional test procedures to determine if it is synergistic. Furthermore, studies of the mode of action can be introduced to determine if the molecule has a different mode of action than other pesticides. This collected data can then be transmitted to third parties via, for example, the Internet.

Therefore, the following additional details (D) are provided in accordance with the above table and the table of the table section.

1D. A molecule with the following formula Formula 1 ^{wherein: (A) R 1, R} 2, R 3, R 4, R 5, R 7, R 8, R 9, and R ¹⁰ are each independently selected from the Department of H, F, Cl, Br, I , CN, NO ₂ , OH, (C ₁ -C ₄ )alkyl, (C ₂ -C ₄ )alkenyl, (C ₁ -C ₄ )haloalkyl, (C ₁ -C ₄ )alkoxy, (C ₁ -C ₄ ) haloalkoxy, and (C ₃ -C ₆ )cycloalkyl, wherein each alkyl, alkenyl, haloalkyl, alkoxy, haloalkoxy, cycloalkyl Optionally substituted with one or more substituents independently selected from the group consisting of H, F, Cl, Br, I, CN, NO ₂ , OH, (C ₁ -C ₄ )alkyl, (C ₂ -C ₄ )alkenyl, (C ₁ -C ₄ )haloalkyl, (C ₁ -C ₄ )alkoxy, (C ₁ -C ₄ )haloalkoxy, and (C ₃ -C ₆ ) a cycloalkyl group, preferably, R ¹ , R ² , R ³ , R ⁴ , R ⁵ , R ⁷ , R ⁸ , R ⁹ , and R ¹⁰ are each independently selected from H, (C ₁ -C ₄ a haloalkyl group, and a (C ₁ -C ₄ ) haloalkoxy group, more preferably, R ¹ , R ² , R ³ , R ⁴ , R ⁵ , R ⁷ , R ⁸ , R ⁹ , and R ¹⁰ are each independently selected from H, CF _3, and OCF _3; (B) R ⁶ is H; (C) L is selected based on (1) a Which ring carbon attached to the nitrogen, and _{(2) (C 1 -C 4} ) alkyl, wherein the alkyl type selectively in one or more substituents independently selected from the following substituent group to be substituted with: F, Cl, CN, OH and pendant oxygen, preferably, L is a bond which connects the nitrogen to the carbon on the ring; (D) R ¹¹ is selected from the group consisting of: H, (C ₁ -C ₄ )alkyl, (C ₂ -C ₄ )alkenyl, (C ₂ -C ₄ )alkenyloxy, (C ₂ -C ₄ )alkynyl, (C ₂ -C ₄ )alkynyloxy, ( C ₁ -C ₄ )haloalkyl, (C ₁ -C ₄ )alkoxy, (C ₁ -C ₄ )haloalkoxy, (C ₃ -C ₆ )cycloalkyl, (C ₃ -C ₆ a cycloalkoxy group, a (C ₃ -C ₆ )cycloalkenyl group, a (C ₃ -C ₆ )cycloalkenyloxy group, ((C ₁ -C ₄ )alkyl ((C ₃ -C ₆ ) cycloalkyl) ), C(O)((C ₁ -C ₄ )alkyl), ((C ₁ -C ₄ )alkyl)C(O)((C ₁ -C ₄ )alkyl), ((C ₁ - C ₄ )alkyl)C(O)O((C ₁ -C ₄ )alkyl), and C(S)NH ₂ , wherein each alkyl, alkenyl, alkenyloxy, alkynyl, alkynyloxy group , haloalkyl, alkoxy, haloalkoxy, cycloalkyl, cycloalkoxy, cycloalkenyl, and cycloalkenyloxy are optionally substituted one or more independently selected from the group consisting of Base On behalf of: H, F, Cl, Br , I, CN, NO 2, OH and the oxygen side, preferably, R ¹¹ is H; (E) R ¹² and R ¹³ is (G) or each independently selected from a group consisting of H, (C ₁ -C ₄ )alkyl, (C ₂ -C ₄ )alkenyl, (C ₂ -C ₄ )alkynyl, (C ₁ -C ₄ )haloalkyl, ((C ₁ -C ₄ )alkyl ((C ₃ -C ₆ )cycloalkyl), (C ₁ -C ₄ )alkylphenyl, (C ₁ -C ₄ )alkylheterocyclyl, (( C ₁ -C ₄ )alkyl)C(O)((C ₁ -C ₄ )alkyl), and ((C ₁ -C ₄ )alkyl)C(O)O((C ₁ -C ₄ ) An alkyl group, wherein each alkyl, alkenyl, alkynyl, haloalkyl, cycloalkyl, phenyl, and heterocyclic group is optionally selected from one or more independently selected from the group consisting of Substituents of the group are substituted: F, Cl, CN, OH and pendant oxygen, preferably, R ¹² and R ¹³ are (G) or H; (F) R ¹⁴ , R ¹⁵ , R ¹⁶ , R ¹⁷ , And R ¹⁸ are each independently selected from the group consisting of H, F, Cl, Br, I, CN, NO ₂ , OH, (C ₁ -C ₄ )alkyl, (C ₂ -C ₄ Alkenyl, (C ₂ -C ₄ )alkynyl, (C ₁ -C ₄ )haloalkyl, (C ₁ -C ₄ )alkoxy, (C ₁ -C ₄ )haloalkoxy, (C _3- C ₆ )cycloalkyl, (C ₃ -C ₆ ) cycloalkoxy, phenyl, and (C ₁ -C ₄ )alkylphenyl, wherein each alkyl, alkenyl, alkynyl, haloalkyl, alkoxy, haloalkoxy, The cycloalkyl, cycloalkoxy, cycloalkenyl, and phenyl groups are optionally substituted with one or more substituents independently selected from the group consisting of F, Cl, Br, I, CN, NO ₂ And OH; preferably, R ¹⁴ , R ¹⁵ , R ¹⁶ , R ¹⁷ , and R ¹⁸ are each independently selected from the group consisting of H, (C ₁ -C ₄ )alkyl, (C ₁ -C ₄ ) alkoxy, (C ₁ -C ₄ )haloalkoxy, phenyl, and (C ₁ -C ₄ )alkylphenyl, more preferably, R ¹⁴ , R ¹⁵ , R ¹⁶ , R ¹⁷ and R ¹⁸ are each independently selected from the group consisting of H, CH ₃ , CH ₂ CH ₃ , CH ₂ CH ₂ CH ₃ , CH(CH ₃ ) ₂ , OCH ₃ , OCF ₃ , Phenyl, and CH ₂ phenyl; (G) R ¹² and R ¹³ together with (NH)C ^x (N ^x ) form a 4 to 8 membered heterocyclic ring, wherein the heterocyclic ring may optionally be one or more Substituents independently selected from R ¹⁹ are substituted, wherein R ¹⁹ is selected from the group consisting of H, F, Cl, Br, I, CN, OH, (C ₁ - C ₄ ) alkyl, pendant oxygen, (C ₁ -C ₄ )alkyl, (C ₂ -C ₄ )alkenyl, (C ₂ -C ₄ )alkynyl, (C ₁ -C ₄ )haloalkyl, ((C ₁ -C ₄ )alkyl ((C ₃ -C ₆ )cycloalkyl), (C ₁ -C ₄ )alkylphenyl, (C ₁ -C ₄ )alkylheterocyclyl, (( C ₁ -C ₄ )alkyl)C(O)((C ₁ -C ₄ )alkyl), ((C ₁ -C ₄ )alkyl)C(O)O((C ₁ -C ₄ ) a phenyl group, and a heterocyclic group, wherein each alkyl, alkenyl, alkynyl, haloalkyl, cycloalkyl, phenyl, and heterocyclic group is independently one or more independently Substituents selected from the group consisting of F, Cl, Br, I, CN, OH, and pendant oxygen; and the N-oxide of the molecule of Formula 1, agriculturally acceptable acid addition salts a class, a salt derivative, a solvate, an ester derivative, a crystalline polymorph, an isotope, an analytical stereoisomer, and a tautomer, preferably, R ¹² and R ¹³ and (NH) C ^x (N ^x ) together is (1a) (1a), wherein R ¹⁹ is selected from the group consisting of H and side oxygen. 2D. A molecule such as 1D , wherein (A) R ¹ , R ² , R ³ , R ⁴ , R ⁵ , R ⁷ , R ⁸ , R ⁹ , and R ¹⁰ are each independently selected from H, (C ₁ -C ₄ )haloalkyl, and (C ₁ -C ₄ )haloalkoxy; (B) R ⁶ is H; (C) L is a bond which connects the nitrogen to the carbon on the ring; (D) R ¹¹ is H; (E) R ¹² and R ¹³ are (G) or H; (F) R ¹⁴ , R ¹⁵ , R ¹⁶ , R ¹⁷ , and R ¹⁸ are each independently selected from the group consisting of :H, (C ₁ -C ₄ )alkyl, (C ₁ -C ₄ )alkoxy, (C ₁ -C ₄ )haloalkoxy, phenyl, and (C ₁ -C ₄ )alkylbenzene (G) R ¹² and R ¹³ together with (NH)C ^x (N ^x ) (1a) (1a) wherein R ¹⁹ is selected from the group consisting of H and side oxygen. 3D. A molecule such as 1D or 2D, wherein (A) R ¹ , R ² , R ³ , R ⁴ , R ⁵ , R ⁷ , R ⁸ , R ⁹ , and R ¹⁰ are each independently selected from H, CF. ₃ , and OCF ₃ ; (B) R ⁶ is H; (C) L is a bond connecting nitrogen to carbon on the ring; (D) R ¹¹ is H; (E) R ¹² and R ¹³ are (G) ), or ^{H; (F) R 14,} R 15, R 16, R 17, and R ¹⁸ are each independently system selected from the group consisting of the _{following: H, CH 3, CH 2} CH 3, CH 2 CH 2 CH ₃ , CH(CH ₃ ) ₂ , OCH ₃ , OCF ₃ , phenyl, and CH ₂ phenyl; (G) R ¹² and R ¹³ together with (NH)C ^x (N ^x ) are (1a) (1a) wherein R ¹⁹ is selected from the group consisting of H and side oxygen. 4D. A molecule such as 1D, 2D or 3D, wherein the molecule is 5D. A molecule such as 1D, 2D or 3D, wherein the molecule is 6D. A pesticidal composition comprising a molecule of any one of 1D, 2D, 3D, 4D or 5D, further comprising an active ingredient. 7D. A pesticidal composition comprising a molecule of any one of 1D, 2D, 3D, 4D or 5D, further comprising an active ingredient selected from the group consisting of acaricides, algaecides, antifeedants , avicide, fungicide, bird repellent, chemical sterilization agent, fungicide, herbicide safener, herbicide, insect attractant, insect repellent, insecticide, mammalian, mating interference Agents, acaricides, nematicides, plant activators, plant growth regulators, rodenticides, synergists, and virucides. 8D. A pesticidal composition comprising a molecule of any one of 1D, 2D, 3D, 4D or 5D, further comprising an active ingredient selected from the group consisting of AIGA . 9D. A pesticidal composition comprising a molecule of any of 1D, 2D, 3D, 4D or 5D, further comprising AI-1 . 10D. A pesticidal composition comprising a molecule of any of 1D, 2D, 3D, 4D or 5D, further comprising AI-2 . 11D. A pesticidal composition comprising a molecule of any of 1D, 2D, 3D, 4D or 5D, further comprising AI-3 . 12D. An insecticidal composition, comprising 1D, 2D, 3D, 4D, such as molecules of one or any 5D, which further comprises Luoti Lan (Lotilaner). 13D. A pesticidal composition comprising a molecule of any one of 1D, 2D, 3D, 4D or 5D, further comprising a molecule selected from Table A. 14D. A pesticidal composition comprising a molecule of any one of 1D, 2D, 3D, 4D or 5D, further comprising an active ingredient selected from the group consisting of AIGA - 2 . 15D. A pesticidal composition comprising a molecule of any of 1D, 2D, 3D, 4D or 5D, further comprising chlorpyrifos. 16D. A pesticidal composition comprising a molecule of any of 1D, 2D, 3D, 4D or 5D, further comprising a hexaflumuron. 17D. A pesticidal composition comprising a molecule of any of 1D, 2D, 3D, 4D or 5D, further comprising methoxyfenozide. 18D. A pesticidal composition comprising a molecule of any of 1D, 2D, 3D, 4D or 5D, further comprising a polyfluuron. 19D. A pesticidal composition comprising a molecule of any of 1D, 2D, 3D, 4D or 5D, further comprising spinetoram. 20D. A pesticidal composition comprising a molecule of any of 1D, 2D, 3D, 4D or 5D, further comprising spinosad. 21D. A pesticidal composition comprising a molecule of any one of 1D, 2D, 3D, 4D or 5D, further comprising a sulfoxaflor. 22D. A pesticidal composition comprising a molecule of any one of 1D, 2D, 3D, 4D or 5D, further comprising an active ingredient selected from the group consisting of AIGA-2 . 23D. A pesticidal composition comprising a molecule of any of 1D, 2D, 3D, 4D or 5D, further comprising an acequinocyl. 24D. A pesticidal composition comprising a molecule of any of 1D, 2D, 3D, 4D or 5D, further comprising acetamiprid. 25D. A pesticidal composition comprising a molecule of any of 1D, 2D, 3D, 4D or 5D, further comprising acetoprole. 26D. A pesticidal composition comprising a molecule of any of 1D, 2D, 3D, 4D or 5D, further comprising avermectin. 27D. A pesticidal composition comprising a molecule of any of 1D, 2D, 3D, 4D or 5D, further comprising azinphos-methyl. 28D. A pesticidal composition comprising a molecule of any of 1D, 2D, 3D, 4D or 5D, further comprising bifenazate. 29D. A pesticidal composition comprising a molecule of any of 1D, 2D, 3D, 4D or 5D, further comprising bifenthrin. 30D. A pesticidal composition comprising a molecule of any one of 1D, 2D, 3D, 4D or 5D, further comprising a carbaryl. 31D. A pesticidal composition comprising a molecule of any of 1D, 2D, 3D, 4D or 5D, further comprising a carbofuran. 32D. A pesticidal composition comprising a molecule of any of 1D, 2D, 3D, 4D or 5D, further comprising chlorfenapyr. 33D. A pesticidal composition comprising a molecule of any of 1D, 2D, 3D, 4D or 5D, further comprising chlorfluazuron. 34D. A pesticidal composition comprising a molecule of any of 1D, 2D, 3D, 4D or 5D, further comprising chromafenozide. 35D. A pesticidal composition comprising a molecule of any of 1D, 2D, 3D, 4D or 5D, further comprising a clothianidin. 36D. A pesticidal composition comprising a molecule of any of 1D, 2D, 3D, 4D or 5D, further comprising cyfluthrin. 37D. A pesticidal composition comprising a molecule of any of 1D, 2D, 3D, 4D or 5D, further comprising cypermethrin. 38D. A pesticidal composition comprising a molecule of any of 1D, 2D, 3D, 4D or 5D, further comprising deltamethrin. 39D. A pesticidal composition comprising a molecule of any of 1D, 2D, 3D, 4D or 5D, further comprising diafenthiuron. 40D. A pesticidal composition comprising a molecule of any one of 1D, 2D, 3D, 4D or 5D, further comprising emamectin benzoate. 41D. A pesticidal composition comprising a molecule of any of 1D, 2D, 3D, 4D or 5D, further comprising endosulfan. 42D. A pesticidal composition comprising a molecule of any of 1D, 2D, 3D, 4D or 5D, further comprising esfenvalerate. 43D. A pesticidal composition comprising a molecule of any of 1D, 2D, 3D, 4D or 5D, further comprising ethiprole. 44D. A pesticidal composition comprising a molecule of any of 1D, 2D, 3D, 4D or 5D, further comprising etoxazole. 45D. A pesticidal composition comprising a molecule of any of 1D, 2D, 3D, 4D or 5D, further comprising fipronil. 46D. A pesticidal composition comprising a molecule of any of 1D, 2D, 3D, 4D or 5D, further comprising flonicamid. 47D. A pesticidal composition comprising a molecule of any of 1D, 2D, 3D, 4D or 5D, further comprising a fluacrypyrim. 48D. A pesticidal composition comprising a molecule of any of 1D, 2D, 3D, 4D or 5D, further comprising gamma- cyhalothrin. 49D. A pesticidal composition comprising a molecule of any of 1D, 2D, 3D, 4D or 5D, further comprising halofenozide. 50D. A pesticidal composition comprising a molecule of any of 1D, 2D, 3D, 4D or 5D, further comprising indoxacarb. 51D. A pesticidal composition comprising a molecule of any of 1D, 2D, 3D, 4D or 5D, further comprising lambda- cyhalothrin. 52D. A pesticidal composition comprising a molecule of any one of 1D, 2D, 3D, 4D or 5D, further comprising lufenuron 53D. a pesticidal composition comprising, for example, 1D, 2D A molecule of any of 3D, 4D or 5D, further comprising a malathion. 54D. A pesticidal composition comprising a molecule of any of 1D, 2D, 3D, 4D or 5D, further comprising a methodyl. 55D. A pesticidal composition comprising a molecule of any of 1D, 2D, 3D, 4D or 5D, further comprising novaluron. 56D. A pesticidal composition comprising a molecule of any of 1D, 2D, 3D, 4D or 5D, further comprising permethrin. 57D. A pesticidal composition comprising a molecule of any of 1D, 2D, 3D, 4D or 5D, further comprising pyridalyl. 58D. A pesticidal composition comprising a molecule of any of 1D, 2D, 3D, 4D or 5D, further comprising pyrimidifen. 59D. A pesticidal composition comprising a molecule of any of 1D, 2D, 3D, 4D or 5D, further comprising spirodiclofen. 60D. A pesticidal composition comprising a molecule of any of 1D, 2D, 3D, 4D or 5D, further comprising tebufenozide. 61D. A pesticidal composition comprising a molecule of any of 1D, 2D, 3D, 4D or 5D, further comprising thiacloprid. 62D. A pesticidal composition comprising a molecule of any of 1D, 2D, 3D, 4D or 5D, further comprising thiamethoxam. 63D. A pesticidal composition comprising a molecule of any of 1D, 2D, 3D, 4D or 5D, further comprising thiodicarb. 64D. A pesticidal composition comprising a molecule of any of 1D, 2D, 3D, 4D or 5D, further comprising tolfenpyrad. 65D. A pesticidal composition comprising a molecule of any one of 1D, 2D, 3D, 4D or 5D, further comprising ζ-赛宁宁. 66D. A pesticidal composition comprising a molecule of any of 1D, 2D, 3D, 4D or 5D, further comprising a biological insecticide. 67D. A pesticidal composition comprising a molecule of any one of 1D, 2D, 3D, 4D or 5D further comprising an active ingredient derived from an acetylcholinesterase (AChE) inhibitor . 68D. A pesticidal composition comprising a molecule of any one of 1D, 2D, 3D, 4D or 5D further comprising an active ingredient derived from an acetylcholinesterase (AChE) inhibitor . 69D. A pesticidal composition comprising a molecule of any one of 1D, 2D, 3D, 4D or 5D further comprising an active ingredient from a GABA-thyristing chloride channel antagonist . 70D. A pesticidal composition comprising a molecule of any of 1D, 2D, 3D, 4D or 5D, further comprising an active ingredient from a sodium ion channel modulator . 71D. An insecticidal composition, comprising 1D, 2D, 3D, 4D, such as molecules of one or any 5D, which further comprises an active ingredient of the modifier from the competitive type nicotinic acetylcholine (nAChR). 72D. An insecticidal composition, comprising 1D, 2D, one molecule of any such 3D, 4D, or 5D, further comprising an active ingredient from a type nicotinic acetylcholine receptors (the nAChR) allosteric modulators of . 73D. A pesticidal composition comprising a molecule of any of 1D, 2D, 3D, 4D or 5D, further comprising an active ingredient from a chloride channel activator . 74D. A pesticidal composition comprising a molecule of any of 1D, 2D, 3D, 4D or 5D, further comprising an active ingredient from a juvenile hormone mimetic . 75D. A pesticidal composition comprising a molecule of any one of 1D, 2D, 3D, 4D or 5D further comprising an active ingredient from a heterogeneous non-specific ( multiple position) inhibitor . 76D. An insecticidal composition, comprising 1D, 2D, 3D, 4D, such as molecules of one or any 5D, which further comprises an active ingredient from the open string organs (Chordotonal Organs) of modulators. 77D. A pesticidal composition comprising a molecule of any one of 1D, 2D, 3D, 4D or 5D further comprising an active ingredient derived from a sputum growth inhibitor . 78D. A pesticidal composition comprising a molecule of any one of 1D, 2D, 3D, 4D or 5D, further comprising an active ingredient from a microorganism that destroys the intestinal membrane of the insect . 79D. A pesticidal composition comprising a molecule of any one of 1D, 2D, 3D, 4D or 5D, further comprising an active ingredient from a granulocyte ATP synthase inhibitor . 80D. A pesticidal composition comprising a molecule of any of 1D, 2D, 3D, 4D or 5D, further comprising an active ingredient from an oxidative phosphorylation non-coupling agent via a disrupted proton gradient . 81D. An insecticidal composition, comprising 1D, 2D, one molecule of any such 3D, 4D, or 5D, further comprising an active type from nicotine acetylcholine receptors (the nAChR) channel blocker component of . 82D. An insecticidal composition, comprising 1D, 2D, 3D, 4D, such as molecules of one or any 5D, which further comprises a substance derived from chitin biosynthesis inhibitors, type 0, of the active ingredient. 83D. An insecticidal composition, comprising 1D, 2D, 3D, 4D, such as molecules of one or any 5D, which further comprises a substance derived from chitin biosynthesis inhibitors, type 1, of the active ingredient. 84D. A pesticidal composition comprising a molecule of any one of 1D, 2D, 3D, 4D or 5D, further comprising an active ingredient from a diptera peeling interferer . 85D. A pesticidal composition comprising a molecule of any one of 1D, 2D, 3D, 4D or 5D, further comprising an active ingredient from a ecdysone receptor synergist . 86D. A pesticidal composition comprising a molecule of any one of 1D, 2D, 3D, 4D or 5D, further comprising an active ingredient from a octopamine receptor synergist . 87D. A pesticidal composition comprising a molecule of any one of 1D, 2D, 3D, 4D or 5D further comprising an active ingredient from a Granular Gland Complex III electron transport inhibitor . 88D. A pesticidal composition comprising a molecule of any of 1D, 2D, 3D, 4D or 5D, further comprising an active ingredient from a granular gland complex I electron transport inhibitor . 89D. A pesticidal composition comprising a molecule of any one of 1D, 2D, 3D, 4D or 5D further comprising an active ingredient from a voltage- dependent sodium ion channel blocker . 90D. A pesticidal composition comprising a molecule of any one of 1D, 2D, 3D, 4D or 5D further comprising an active ingredient from an acetaminophen A carboxylase inhibitor . 91D. A pesticidal composition comprising a molecule of any of 1D, 2D, 3D, 4D or 5D, further comprising an active ingredient from a granular gland complex IV electron transport inhibitor . 92D. A pesticidal composition comprising a molecule of any one of 1D, 2D, 3D, 4D or 5D further comprising an active ingredient from a Granular Gland Complex II electron transport inhibitor . 93D. An insecticidal composition which comprises as 1D, 2D, 3D, in any one of molecular 4D or 5D, further comprising an active ingredient from Luona Dan receptacle (R yanodine receptor) modulators of. 94D. A pesticidal composition comprising a molecule of any one of 1D, 2D, 3D, 4D or 5D, further comprising an active ingredient from the UN group . 95D. The insecticidal composition according to any one of 6D to 94D, wherein the weight ratio of the molecule of formula 1 to the active ingredient is from 100:1 to 1:100. 96D. The insecticidal composition according to any one of the above, wherein the weight ratio of the molecule to the active ingredient is from 50:1 to 1:50. The 6D to 97D and 94D of one of the pesticidal encompasses any composition, wherein the formula weight ratio of one molecule of active ingredient is 20: 1 to 1 20. 98D. The insecticidal composition according to any one of 6D to 94D, wherein the weight ratio of the molecule of formula 1 to the active ingredient is from 10:1 to 1:10. 99D. The insecticidal composition according to any one of 6D to 94D, wherein the weight ratio of the molecule of formula 1 to the active ingredient is from 5:1 to 1:5. 100D. The insecticidal composition according to any one of 6D to 94D, wherein the weight ratio of the molecule of formula 1 to the active ingredient is from 3:1 to 1:3. 101D. The insecticidal composition according to any one of 6D to 94D, wherein the weight ratio of the molecule of formula 1 to the active ingredient is from 2:1 to 1:2. 102D. The insecticidal composition according to any one of 6D to 94D, wherein the weight ratio of the molecule of formula 1 to the active ingredient is 1:1. 103D. The insecticidal composition according to any one of 6D to 94D, wherein the weight ratio of the molecule of formula 1 to the active ingredient is X:Y ; wherein X is the weight part of the molecule of formula 1 and Y is the active ingredient Parts by weight; further wherein the value of X parts by weight is 0 < X ≤ 100 and the value of Y parts by weight is 0 < Y ≤ 100; and further wherein X and Y are selected from Table C. 104D. The insecticidal composition of 103D, wherein the weight ratio of the molecular weight to the active ingredient of Formula 1 is in the range of X ₁ : Y ₁ to X ₂ : Y ₂ ; further wherein X ₁ &gt; Y ₁ and X _{2 &} lt; Y ₂ . 105D. The insecticidal composition of 103D, wherein the weight ratio of the molecule of formula 1 to the active ingredient is in the range of X ₁ : Y ₁ to X ₂ : Y ₂ ; further wherein X ₁ &gt; Y ₁ and X ₂ &gt; Y ₂ . 106D. The insecticidal composition of 103D, wherein the weight ratio of the molecule of formula 1 to the active ingredient ranges from X ₁ : Y ₁ to X ₂ : Y ₂ ; further wherein X _{1 &} lt; Y ₁ and X _{2 &} lt; Y ₂ . 107D . The insecticidal composition of any of 6D to 106D, wherein the pesticidal composition further comprises ammonium sulfate. 108D. The insecticidal composition of any of 6D to 106D, wherein the pesticidal composition is synergistic. 109D. A method of producing a pesticidal composition, the method comprising mixing a molecule such as a request item such as 1D, 2D, 3D, 4D or 5D with one or more active ingredients. 110D. A method of testing a pesticidal composition such as 109D to determine if it is synergistic. 111D. A pesticidal composition comprising a molecule such as 1D, 2D, 3D, 4D or 5D and a seed. 112D. A molecule of any of 1D, 2D, 3D, 4D or 5D, wherein the molecule is in the form of an agriculturally acceptable acid addition salt. 113D. A molecule according to any one of 1D, 2D, 3D, 4D or 5D, wherein the molecule is in the form of a salt derivative. 114D. A molecule of any of 1D, 2D, 3D, 4D or 5D, wherein the molecule is in the form of a solvate. 115D. A molecule of any of 1D, 2D, 3D, 4D or 5D, wherein the molecule is in the form of a crystalline polymorph. 116D. A molecule according to any one of 1D, 2D, 3D, 4D or 5D, wherein the molecule has a combination of ruthenium, osmium, radiocarbon or the like. 117D. A molecule of any of 1D, 2D, 3D, 4D or 5D, wherein the molecule is in the form of one or more stereoisomers. 118D. A molecule of any of 1D, 2D, 3D, 4D or 5D, wherein the molecule is in the form of a resolved stereoisomer. 119D. A method of controlling pests, comprising applying a pesticidally effective amount of a molecule such as 1D, 2D, 3D, 4D or 5D to a locus. 120D. A method of controlling pests, comprising applying a pesticidally effective amount of a pesticidal composition, such as from 56 to 108D, to a locus. 121D. The method of 119D or 120D, wherein the pest is selected from the group consisting of an ant, a locust, a bed bug, a beetle, a bristletails, a caterpillar, a donkey, a donkey, an earwig, a flea, a fly,蚱蜢, 螬, leaf 蝉, 虱, 蝗 蛆, 蛆, 螨, nematode, planthopper, psyllids, sawflies, scale insects, silverfish, crickets, snails , spiders, caterpillars, bed bugs, symphylans, termites, thrips, ticks, wasps, whiteflies, and wireworms. 122D. The method of 119D or 120D, wherein the pest is selected from the group consisting of Subphyla Chelicerata , Myriapoda , or Hexapoda . 123D. The method 119D or 120D, the system wherein the pest is selected from the Arachnida (Arachnida), Symphyla (the Symphyla), or Insecta (Insecta). 124D. The method of 119D or 120D, wherein the pest is selected from the group consisting of Order Anoplura . 125D. The method of 119D or 120D, wherein the pest is selected from the group consisting of the order Coleoptera . 126D. The method of 119D or 120D, wherein the pest is selected from the group consisting of Order Dermaptera . 127D. The method of 119D or 120D, wherein the pest is selected from the group consisting of Order Blattaria . 128D. The method of 119D or 120D, wherein the pest is selected from the group consisting of Order Diptera . 129D. The method of 119D or 120D, wherein the pest is selected from the group consisting of Order Hemiptera . 130D. The method of 119D or 120D, wherein the pest is selected from the group consisting of the Order Hymenoptera . 131D. The method of 119D or 120D, wherein the pest is selected from the group consisting of the Order Isoptera . 132D. The method of 119D or 120D, wherein the pest is selected from within the order Lepidoptera (Order Lepidoptera). 133D. The method of 119D or 120D, wherein the pest is selected from the group consisting of Order Mallophaga . 134D. The method of 119D or 120D, wherein the pest is selected from the group consisting of Order Orthoptera . 135D. The method 119D or 120D of, wherein the pest is selected from at Psocoptera (Order Psocoptera). 136 D. The method of 119D or 120D, wherein the pest is selected from the group consisting of Order Siphonaptera . 137D. The method of 119D or 120D, wherein the pest is selected from at Thysanoptera (Order Thysanoptera). 138D. The method 119D or 120D, the system wherein the pest is selected from the Thysanura (Order Thysanura). 139D. The method of 119D or 120D, wherein the pest is selected from the group consisting of Order Acarina . 140D. The method of 119D or 120D, wherein the pest is selected based on the true Araneae (Order Araneae). 141D. The method 119D or 120D of, wherein the pest is selected from the junction to the valve classes (Class Symphyla). 142D. The method of 119D or 120D, wherein the pest is selected from the tube to stick subclass (Subclass Collembola). 143D. The method 119D or 120D of, wherein the pest is selected from the phylum circular (Phylum Nematoda). 144D. The method 119D or 120D of, in which the pest is selected from Mollusca (Phylum Mollusca). 145D. The method of 119D or 120D, wherein the pest insects feeding line of juice. 146D. The method of 145D, wherein the pest is selected from the group consisting of aphids, leafhoppers, moths, scales, thrips, psyllids, melybugs, bed bugs, and powders. louse. 147D. The method of 145D, wherein the pest is selected from at Phthiraptera (Order Anoplura) and Hemiptera (Order Hemiptera). 148D. The method of 145D, wherein the pest is selected from the group consisting of Aulacaspis spp., Aphrophora spp., Aphis spp., Bemisia spp. , Coccus spp., Euschistus spp., Lygus spp., Macrosiphum spp., Nezara spp., and Rhopalosiphum spp. 149 D. The method of 119D or 120D, wherein the pest is a chewy pest. 150D. The method of 149D, wherein the pest is selected from the group consisting of a caterpillar, a beetle, a cockroach, and a mites. 151D. The method of 149D, wherein the pest is selected from the group consisting of Coleoptera and Lepidoptera. 152D. The method of 149D, wherein the pest is selected from the group consisting of Acanthoscelides spp., Cerotoma spp., Chaetocnema spp., Colaspis spp. ), Cyclocephala spp., Diabrotica spp., Hypera spp., Phyllophaga spp., Phyllotreta spp. , Sphenophorus spp., Sitophilus spp. 153D. The method of 119D or 120D, wherein the locus is alfalfa, almond, apple, barley, beans, rape, corn, cotton, cruciferous, lettuce, oat, orange, peanut, pear, pepper, potato, rice , sorghum, soybeans, strawberries, sugar cane, sugar beets, sunflowers, tobacco, tomatoes, wheat, and other valuable crops or where they are grown. 154 D. The method of 119D or 120D, wherein the locus is genetically modified to represent a particular trait of planting. 155D. The method of 119D or 120D, wherein the administration based on plant leaves and / or fruit part of the implementation. 156 D. The method of 119D or 120D, wherein the applying is carried out in soil. 157D. The method of 119D or 120D, wherein the applying is performed by drip irrigation, strip application, or soil watering before or after planting. 158D . The method of 119D or 120D, wherein the applying is performed on a plant leaf and/or fruit portion, or by pre-planting the plant seed. 159D. A method comprising administering a molecule, such as 1D, 2D, 3D, 4D or 5D, to a seed. 160D. A method comprising administering a molecule such as 1D, 2D, 3D, 4D or 5D to a locus comprising non-human animal breeding fields to control parasites, ectoparasites and both.

The headings in this document are for convenience only and should not be used to interpret any part of this document. Table B Table C Table 2. Structure and preparation method of F series molecules * Prepare according to the example number. Table 3. Structure and preparation method of C series molecules * Prepare Table 4 for the analysis of the compounds in Table 2 according to the example numbers. Table ABC : Biological Results

(no)

Claims (8)

a molecule with the following formula Formula 1 ^{wherein: (A) R 1, R} 2, R 3, R 4, R 5, R 7, R 8, R 9, and R ¹⁰ are each independently selected from the Department of H, F, Cl, Br, I , CN, NO ₂ , OH, (C ₁ -C ₄ )alkyl, (C ₂ -C ₄ )alkenyl, (C ₁ -C ₄ )haloalkyl, (C ₁ -C ₄ )alkoxy, (C ₁ -C ₄ ) haloalkoxy, and (C ₃ -C ₆ )cycloalkyl, wherein each alkyl, alkenyl, haloalkyl, alkoxy, haloalkoxy, cycloalkyl Optionally substituted with one or more substituents independently selected from the group consisting of H, F, Cl, Br, I, CN, NO ₂ , OH, (C ₁ -C ₄ )alkyl, (C ₂ -C ₄ )alkenyl, (C ₁ -C ₄ )haloalkyl, (C ₁ -C ₄ )alkoxy, (C ₁ -C ₄ )haloalkoxy, and (C ₃ -C ₆ ) a cycloalkyl group; (B) R ⁶ is H; (C) L is selected from the group consisting of (1) a bond linking a nitrogen to a ring carbon, and (2) a (C ₁ -C ₄ ) alkyl group, wherein The alkyl group is optionally substituted with one or more substituents independently selected from the group consisting of F, Cl, CN, OH and pendant oxygen; (D) R ¹¹ is selected from the group consisting of _{group: H, (C 1 -C 4} ) alkyl, (C ₂ -C ₄₎ alkenyl, (C ₂ -C ₄₎ alkenyloxy (C ₂ -C ₄₎ alkynyl, (C ₂ -C ₄₎ alkynyloxy, (C ₁ -C ₄₎ haloalkyl, (C ₁ -C ₄₎ alkoxy, (C ₁ -C ₄₎ Haloalkoxy, (C ₃ -C ₆ )cycloalkyl, (C ₃ -C ₆ )cycloalkoxy, (C ₃ -C ₆ )cycloalkenyl, (C ₃ -C ₆ )cycloalkenyloxy , ((C ₁ -C ₄ )alkyl ((C ₃ -C ₆ )cycloalkyl), C(O)((C ₁ -C ₄ )alkyl), ((C ₁ -C ₄ )alkyl) C(O)((C ₁ -C ₄ )alkyl), ((C ₁ -C ₄ )alkyl)C(O)O((C ₁ -C ₄ )alkyl), and C(S) NH ₂ , wherein each alkyl, alkenyl, alkenyloxy, alkynyl, alkynyloxy, haloalkyl, alkoxy, haloalkoxy, cycloalkyl, cycloalkoxy, cycloalkenyl, and The cycloalkenyloxy group is optionally substituted with one or more substituents independently selected from the group consisting of H, F, Cl, Br, I, CN, NO ₂ , OH and pendant oxygen; (E) R ¹² and R ¹³ are (G) or each independently selected from the group consisting of H, (C ₁ -C ₄ )alkyl, (C ₂ -C ₄ )alkenyl, (C ₂ -C ₄ Alkynyl, (C ₁ -C ₄ )haloalkyl, ((C ₁ -C ₄ )alkyl ((C ₃ -C ₆ )cycloalkyl), (C ₁ -C ₄ )alkylphenyl, (C ₁ -C ₄ )alkylheterocyclyl, ((C ₁ -C ₄ )alkyl)C(O)((C ₁ -C ₄ )alkyl), and (( C ₁ -C ₄ )alkyl)C(O)O((C ₁ -C ₄ )alkyl), wherein each alkyl, alkenyl, alkynyl, haloalkyl, cycloalkyl, phenyl, and The heterocyclic group is optionally substituted with one or more substituents independently selected from the group consisting of F, Cl, CN, OH and pendant oxygen; (F) R ¹⁴ , R ¹⁵ , R ¹⁶ , R ¹⁷ , and R ¹⁸ are each independently selected from the group consisting of H, F, Cl, Br, I, CN, NO ₂ , OH, (C ₁ -C ₄ )alkyl, (C ₂ -C ₄ )alkenyl, (C ₂ -C ₄ )alkynyl, (C ₁ -C ₄ )haloalkyl, (C ₁ -C ₄ )alkoxy, (C ₁ -C ₄ )halide Alkoxy, (C ₃ -C ₆ )cycloalkyl, (C ₃ -C ₆ )cycloalkoxy, phenyl, and (C ₁ -C ₄ )alkylphenyl, wherein each alkyl, alkene a base, an alkynyl group, a haloalkyl group, an alkoxy group, a haloalkoxy group, a cycloalkyl group, a cycloalkoxy group, a cycloalkenyl group, and a phenyl group are optionally independently selected from one or more of the following Substituents are substituted: F, Cl, Br, I, CN, NO ₂ and OH; (G) R ¹² and R ¹³ together with (NH)C ^x (N ^x ) form a 4 to 8 membered heterocyclic ring, wherein The heterocyclic ring may optionally be one or more Substituted from a substituent selected from R ¹⁹ wherein R ¹⁹ is selected from the group consisting of H, F, Cl, Br, I, CN, OH, (C ₁ -C ₄ )alkyl, Side oxygen, (C ₁ -C ₄ )alkyl, (C ₂ -C ₄ )alkenyl, (C ₂ -C ₄ )alkynyl, (C ₁ -C ₄ )haloalkyl, ((C ₁ -C) ₄ ) alkyl ((C ₃ -C ₆ )cycloalkyl), (C ₁ -C ₄ )alkylphenyl, (C ₁ -C ₄ )alkylheterocyclyl, ((C ₁ -C ₄ ) Alkyl)C(O)((C ₁ -C ₄ )alkyl), ((C ₁ -C ₄ )alkyl)C(O)O((C ₁ -C ₄ )alkyl), phenyl, And a heterocyclic group wherein each alkyl, alkenyl, alkynyl, haloalkyl, cycloalkyl, phenyl, and heterocyclic group is optionally selected from one or more independently selected from the following Substituents of the group are substituted: F, Cl, Br, I, CN, OH and pendant oxygen; and the N-oxide of the molecule of formula 1, agriculturally acceptable acid addition salts, salt derivatives , solvates, crystalline polymorphs, isotopes, resolved stereoisomers, and tautomers. The molecule of claim 1, wherein: (A) R ¹ , R ² , R ³ , R ⁴ , R ⁵ , R ⁷ , R ⁸ , R ⁹ , and R ¹⁰ are each independently selected from H, (C) ₁ -C ₄ )haloalkyl, and (C ₁ -C ₄ )haloalkoxy; (B) R ⁶ is H; (C) L is a bond which connects the nitrogen to the carbon on the ring; (D) R ¹¹ is H; (E) R ¹² and R ¹³ are (G) or H; (F) R ¹⁴ , R ¹⁵ , R ¹⁶ , R ¹⁷ , and R ¹⁸ are each independently selected from the group consisting of Group: H, (C ₁ -C ₄ )alkyl, (C ₁ -C ₄ )alkoxy, (C ₁ -C ₄ )haloalkoxy, phenyl, and (C ₁ -C ₄ )alkyl Phenyl; (G) R ¹² and R ¹³ together with (NH)C ^x (N ^x ) are (1a) (1a), wherein R ¹⁹ is selected from H and from the group consisting of oxygen side. The molecule of claim 1, wherein: (A) R ¹ , R ² , R ³ , R ⁴ , R ⁵ , R ⁷ , R ⁸ , R ⁹ , and R ¹⁰ are each independently selected from H, CF ₃ And OCF ₃ ; (B) R ⁶ is H; (C) L is a bond connecting nitrogen to carbon on the ring; (D) R ¹¹ is H; (E) R ¹² and R ¹³ are (G) Or H; (F) R ¹⁴ , R ¹⁵ , R ¹⁶ , R ¹⁷ , and R ¹⁸ are each independently selected from the group consisting of H, CH ₃ , CH ₂ CH ₃ , CH ₂ CH ₂ CH ₃ , CH(CH ₃ ) ₂ , OCH ₃ , OCF ₃ , phenyl, and CH ₂ phenyl; (G) R ¹² and R ¹³ together with (NH)C ^x (N ^x ) (1a) (1a), wherein R ¹⁹ is selected from H and from the group consisting of oxygen side. The molecule of claim 1, wherein the molecule is . The molecule of claim 1, wherein the molecule is . A pesticidal composition comprising the molecule of any one of claims 1, 2, 3 or 4, further comprising an active ingredient. A method of controlling pests, comprising applying a pesticidally effective amount of a molecule of any one of claims 1, 2, 3, 4 or 5 to a locus. A method of controlling pests, comprising applying a pesticidally effective amount of the pesticidal composition of claim 6 to a locus.