TW201618746A - Exothermic composition for oral use and toothpaste composition - Google Patents

Abstract

The present invention relates to an exothermic oral composition comprising an anhydrous zeolite, a polyol and a binder.

Description

Oral heating composition and toothpaste composition thereof

The present invention relates to an oral heat generating composition.

The present application claims the benefit of the filing date of the Korean Patent Application No. 10-2014-0149863 filed on Jan. 31, 2014, the entire disclosure of which is incorporated herein.

The toothpaste which is used for the purpose of removing foreign matter such as calculus on the tooth surface contains fluorine which is a representative anti-caries agent, and is used for the purpose of preventing dental caries. In addition to the anti-caries agent, a wetting agent, a binder, a medicinal agent, an abrasive, and the like are usually used as a main component in the components constituting the toothpaste.

In the toothpaste, in addition to the purpose of preventing dental caries, in order to prevent inflammation of the gums such as gingivitis or alveolar pus, and to destroy periodontal disease of periodontal tissues, an additive for promoting blood circulation of the gums is used.

A technique for preparing a toothpaste having heat-generating characteristics using anhydrous zeolite is disclosed in U.S. Patent Application Publication No. 4,644,451. When the anhydrous zeolite is brought into contact with water such as saliva in the oral cavity, heat of a degree of warmth is generated by the hydration reaction of the zeolite, thereby promoting blood circulation of the gums.

However, in U.S. Patent No. 4,474,451, deacetylated heteropolysaccharide S-60 is used as a binder together with anhydrous zeolite, but stability as a toothpaste cannot be ensured.

Further, with the conventional paste toothpaste, in order to prevent separation of the abrasive and the liquid component, the morphological stability of the preparation material is maintained, thereby imparting appropriate viscosity, and using a binder for adjusting the foam, however, for the creamy toothpaste, A wetting agent is generally required in order to impart suitable moisture and plasticity to the preparation material and to prevent dry curing of the toothpaste.

Therefore, for a composition of a heated toothpaste containing an anhydrous zeolite, it is required to have a wetting agent at the same time as stability, so as to maintain the viscosity, and a phenomenon of hydrating shrinkage of solid and liquid separation does not occur.

Further, there is known a technique in which an anhydrous calcium chloride having excellent heat generation characteristics is used in hydration to provide a warm feeling at the time of rinsing, but calcium chloride is actually used as a characteristic bitter taste. There is a problem with the use of toothpaste.

Problem to be solved by the invention

The present inventors have an object to provide an oral heat-generating composition which contains anhydrous zeolite and thus has heat-generating properties in the oral cavity and also contains a wetting agent, thereby providing suitable moisture to the preparation material. And plasticity, while maintaining the viscosity for a long time, the syneresis phenomenon of solid and liquid separation is also improved.

Technical means of solving problems

In order to achieve the above object, the present invention provides an oral heat-generating composition comprising an anhydrous zeolite, a polyol, and a binder.

Control the efficacy of prior art

The oral heat-generating composition according to the present invention contains an anhydrous zeolite and thus has a heat-generating property in the oral cavity, and also contains a wetting agent, thereby also providing suitable moisture and plasticity to the preparation material while being stored for a long period of time. It is also capable of maintaining viscosity and suppressing the syneresis phenomenon in which solids and liquids are separated.

Further, since the oral heat-generating composition of the present invention contains anhydrous zeolite, even when it is an anhydrous dosage form, it has a relatively good mouthfeel at the time of mouthwashing, and is excellent in heat generation characteristics.

The present invention provides an oral heat-generating composition comprising anhydrous zeolite, a polyol and a binder.

Since the oral heat-generating composition of the present invention contains anhydrous zeolite, it generates heat when it reacts with water, so that when a toothpaste is used, a warm feeling can be felt, and an anhydrous taste containing a characteristic bitterness and a salty taste is not good. In the case of calcium chloride, the bitterness and the salty taste are not strong, and therefore the feeling of use is excellent.

In one embodiment of the present invention, the anhydrous zeolite is not particularly limited as long as it is an anhydrous zeolite which generates heat by reaction with water, and is, for example, a general formula xM _2/n O such as zeolite A, zeolite X, zeolite Y or zeolite L. - Al ₂ O ₃ ·ySiO ₂ ·zH ₂ O (wherein x, y and z represent an arbitrary number, M represents an alkali metal or an alkaline earth metal, and n represents the valence of the valence.) The anhydride of the zeolite.

In one embodiment of the present invention, the polyol is one or more selected from the group consisting of glycerin, propylene glycol, butylene glycol, dipropylene glycol, and polyethylene glycol. When the polyol is in a water-free state, it can be heated while being hydrated, and in particular, polyethylene glycol has the most excellent heat generation ability, which is preferable.

In one embodiment of the present invention, the binder is one or more selected from the group consisting of polyvinylpyrrolidone, an acrylate polymer, and a polyoxyethylene-polyoxypropylene-polyoxyethylene block copolymer.

In the conventional toothpaste, since a large amount of water is mixed, the water-soluble polymer is used as a binder. However, in order to maintain the heat generation characteristics of the zeolite contained in the present invention, the zeolite should be an anhydrous dosage form, and therefore In contrast, when a water-soluble polymer acts in an aqueous solution, a desired effect cannot be obtained. In contrast, polyvinylpyrrolidone, an acrylate polymer, and a polyoxyethylene-polyoxypropylene-polyoxyethylene block copolymer and their When used in combination as an adhesive in an anhydrous dosage form, the effect is also excellent.

The above acrylate-based polymer may specifically be polyacrylate or sodium acrylate, and more specifically, may be manufactured by Lubrizol Corporation under the trade name carbomer 980 or under the trade name carbomer 940. The product.

The above polyoxyethylene-polyoxypropylene-polyoxyethylene (PEG-PPG-PEG) block copolymer, the polyoxypropylene molecular mass of the polyoxypropylene (PPG) block is 4,000 g/mol, and the overall polyoxygenation The ethylene-polyoxypropylene-polyoxyethylene block copolymer mass meter, the polyoxyethylene may be 70% by mass, specifically, may be poloxamer 407 (Poloxamer 407), and more specifically, may be BASF (BASF) The company's trade name is Pluronic F127 or the product sold under the trade name Synperonic PE/F 127 by Croda.

The above polyoxyethylene-polyoxypropylene-polyoxyethylene (PEG-PPG-PEG) block copolymer, the polyoxypropylene molecular mass of the polyoxypropylene (PPG) block is 4,000 g/mol, and the overall polyoxygenation The ethylene-polyoxypropylene-polyoxyethylene block copolymer mass meter, the polyoxyethylene may be 80% by mass, specifically, may be poloxamer 188 (Poloxamer 188), and more specifically, may be BASF (BASF) The company's trade name is Pluronic F68 (Pluronic F68) or a product made by Heda Company under the trade name Synperonic PE/F68.

In one embodiment of the present invention, the content of the anhydrous zeolite is 5% by mass or more and 50% by mass or less based on the total mass of the composition. When the content of the anhydrous zeolite is 5% by mass or less, the effect of heat generation is hardly felt at the time of rinsing, and if it is 50% by mass or more, there is a problem that pain is felt when there is excessive sputum.

In one embodiment of the present invention, the content of the polyol is 30% by mass or more and 80% by mass or less based on the total mass of the composition. When the content of the polyol is 30% by mass or less, the dosage form becomes too hard due to an excessive amount of the powder, and if it is 80% by mass or more, the amount of the powder which can be mixed in the dosage form due to the excessive polyol content is changed. Very little problem with the dosage form.

In one embodiment of the present invention, the content of the binder is 0.1% by mass or more and 5% by mass or less based on the total mass of the composition. When the content of the binder is 0.1% by mass or less, the phase separation phenomenon cannot be suppressed during long-term storage, and if it is 5% by mass or more, excessive adhesion is caused, and it is difficult to mix in preparation, and the composition is filled into a container. There are also problems in the middle.

In one embodiment of the present invention, the oral heat-generating composition further comprises a selected from the group consisting of an expectorant, a periodontal disease preventive agent, a tooth cold acid reliever, a tooth whitening agent, an abrasive, a foaming agent, a flavoring agent, and a sweetener. Any one or two or more of a taste agent and a preservative.

The anti-caries agent may be any one or more selected from the group consisting of sodium monofluorophosphate, sodium fluoride, and tin fluoride.

The periodontal disease preventive agent may be selected from the group consisting of allantoin, dipotassium glycyrrhizinate, ε-aminocaproic acid, tranexamic acid, hinokitiol, lysozyme, vitamin E, and vitamin E. Any one or two or more of a derivative and sodium chloride.

The dental cold acid relieving agent may be any one or more selected from the group consisting of potassium nitrate, tricalcium phosphate, and barium chloride.

The polishing agent may be any one or more selected from the group consisting of heavy calcium carbonate, precipitated calcium carbonate, and cerium oxide.

The above blowing agent may be sodium lauryl sulfate.

The above scenting agent may be menthol and/or peppermint oil.

The sweetener may be any one or more selected from the group consisting of saccharin, stevioside, and xylitol. The above saccharin may be sodium saccharin or calcium saccharin.

The above preservative may be methyl p-hydroxybenzoate and/or butyl benzoate.

The tooth whitening agent may be any one or more selected from the group consisting of hydrogen peroxide, urea peroxide, and calcium peroxide.

The present invention provides a toothpaste comprising the aforementioned oral heat-generating composition.

For an embodiment of the present invention, the toothpaste may be a tooth powder, a liquid toothpaste, and a liquid toothpaste.

Hereinafter, the structure and effects of the present invention will be more specifically described by way of test examples and dosage forms. However, these test examples and the formulation examples are provided for the purpose of exemplifying the understanding of the present invention, and the scope and scope of the present invention are not limited to the following examples.

[Preparation Example 1] Confirmation of Compatibility of Polyol and Binder

The toothpaste compositions of Examples 1 to 3 and Comparative Examples 1 to 6 were prepared by the compositions of Table 1 below. The perfume, sodium saccharin, sodium monofluorophosphate, and a binder (carbomer, polyvinylpyrrolidone, poloxamer, cellulose gum, etc.) are dissolved or dispersed in polyethylene glycol and glycerin as polyols. Then, an inorganic powder such as calcium carbonate, aqueous citric acid, anhydrous zeolite or calcium chloride, and sodium lauryl sulfate are added under vacuum and mixed to prepare a toothpaste composition.

As carbomer, a product manufactured by Lubrizol Corporation under the trade name Carbomer 940 is used, and as polyvinylpyrrolidone, a product manufactured by BASF Corporation under the trade name LUVISCOL K30 is used as a poloxamer. A product manufactured by BASF Corporation under the trade name Lutrol F127 was used.

Table I

*Unit: % of the total mass of the composition

[Test Example 1] Formulation stability

(1) Viscosity change

About 100 g of the toothpaste composition prepared in the examples and the comparative examples was placed in a 100 ml beaker, and measured by a Brookfield viscometer at a spindle speed D of 0.5 rpm for 1 minute, thereby obtaining the results of the following Table 2.

Table II

*Unit: cps

Looking at Table 2, it can be confirmed that the initial viscosity of carbomer, polyvinylpyrrolidone, and poloxamer as a binder is 80,000 cps or more, and the viscosity of 104,000 cps or more after the next day is different. In the case of Comparative Examples 1 to 6 in which other components were used as a binder, the binder hardly contributed to the formation of viscosity.

(2) Phase separation

The toothpaste composition prepared in Preparation Example 1 was stored in an oven at 45 ° C and a loop oven (varied in a temperature range of -10 to 45 ° C), and the phase separation phenomenon was evaluated after one month. The results are as follows: .

<Evaluation criteria>

Good: no phase separation at all

Ordinary: phase separation is very weak

Bad: serious phase separation

Table 3

Observation of Table 3, the results of evaluation of the phase separation phenomenon, it was confirmed that the formulation of Example 2 using polyvinylpyrrolidone was the most excellent in stability, and Example 1 using carbomer and the example using poloxamer were also possible. use. However, it can be known that separation occurs in the binder other than this, and it is difficult to use.

[Preparation Example 2] usability confirmation

The toothpaste compositions of Examples 2, 4 and Comparative Examples 7 and 8 were prepared by the compositions of Table 4 below.

Table 4

*Unit: % of the total mass of the composition

[Test Example 2] Evaluation of use feeling

In this test, in order to investigate the feeling of use of the toothpaste prepared in each of the examples and the comparative examples, the feeling of use was evaluated.

Forty male and female consumers between the ages of 20 and 50 were asked to use a questionnaire survey one week later, and the results are shown in Table 5.

<Evaluation criteria>

Warm feeling: very strong 5, strong 4, normal 3, almost no 2, no 1

Bitterness: very strong 5, strong 4, normal 3, almost no 2, no 1

Stimulation: very strong 5, strong 4, normal 3, almost no 2, no 1

Satisfaction: very good 5, good 4, normal 3, not good 2, very bad 1

table 5

In Comparative Examples 7 and 8 using calcium chloride, since the bitterness and irritation were very strong, the satisfaction was extremely low even under a relatively high warm feeling. On the other hand, in Example 4 containing 50% by mass of anhydrous zeolite, although a strong warm feeling can be felt, the stimulation according thereto is also increased, and an example containing 10% by mass of anhydrous zeolite can be known. 2 Overall satisfaction is excellent.

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Claims (7)

An oral heat-generating composition comprising anhydrous zeolite, a polyol, and a binder. The oral heat-generating composition according to claim 1, wherein the polyol is one or more selected from the group consisting of glycerin, propylene glycol, butylene glycol, dipropylene glycol, and polyethylene glycol. The oral heat-generating composition according to claim 1, wherein the adhesive is selected from the group consisting of polyvinylpyrrolidone, an acrylate polymer, and a polyoxyethylene-polyoxypropylene-polyoxyethylene block copolymer. Any one or two or more. The oral heat-generating composition according to claim 1, wherein the content of the anhydrous zeolite is 5% by mass or more and 50% by mass or less based on the mass of the entire composition. The oral heat-generating composition according to claim 1, wherein the content of the polyol is 30% by mass or more and 80% by mass or less based on the mass of the entire composition. The oral heat-generating composition according to claim 1, wherein the content of the adhesive is 0.1% by mass or more and 5% by mass or less based on the mass of the entire composition. A toothpaste composition comprising the oral heat-generating composition according to any one of claims 1 to 6.