201231117 六、發明說明： 【發明所屬之技術領域】 [0001] 本發明有關一種適用於配施多重劑量的液體藥劑的裝置 ，同時維持其中具有該液體藥劑的容器的無菌。 [先前技術] [0002] 多年來，醫學治療眼睛失調的主要方法已為經由局部投 藥各種液體藥物。典型地，配施器具有各種大小以及配 施的滴液形狀，但沒有由點滴器（配施器）尖決定的可 再現的標準滴液大小。此外，當試圖使用局部製備品， 像是例如眼用滴液時，典型病患經歷的最常見問題是浪 費的問題。當滴液被導入眼睛中時，平均下結膜腔只保 留四分之一至二分之一的標準滴液。剩下的不是經臉頰 流下，就是被淚腺系統排出。除了配施非均勻大小滴液 的問題之外，也有與在該液體藥劑中使用防腐劑有關的 問題。例如，「氣化苯二甲烴銨」（一種已知的防腐劑） 被報導在慢性治療中的使用會導致對角膜的傷害〔Cha et a 1 in Clin Experiment Ophthalmol. 2004 Apr; 32 ( 2 ) :180-4〕。現在所熟知的是，已將防腐劑 與副作用以及過敏反應連結，因此，可以說有一個未滿 足的需要是，可預防以上所提及的浪費問題以及可提供 包括無防腐劑藥劑之可行性的理想裝置，其中該裝置的 設計維持該藥劑的無菌。 回顧先前技術，可看到做出許多努力以設計出一種適合 運送用於局部投藥的液體藥劑的裝置。例如，歐洲專利 申請案EP 1 779832描述了一種擠壓容器，該擠壓容器包 含用於容納液體的容器本體以及通到該容器本體開口端 1()()14733#單編號A0101 第4頁/共40頁 1013146740-0 201231117 的頸部，其中該容器本體具有摺箱，該摺箱以大體上垂 直於該液體經由該頸部排出的運送方向的方向收縮與膨 脹’該摺箱具有朝向運送方向配置的多個打摺部分，每 個打摺部分以收縮的方向彼此間隔配置，以垂直於收縮 方向的方向在凸面邊緣做出打摺部分的寬度，以在收縮 方向從中間至兩端減少，以及以垂直於收縮方向的方向 在凹面邊緣做出打摺部分的寬度，以在收縮方向從中間 至兩端減少。 美國專利編號US 6, 336, 571描述了 一種用於包裝用以被 逐滴配施的液體的裝置，該裝置包含可被手動變形的彈 性壁面瓶（1)，以朝向硬頸（5)而逐漸減少其内部體 積’在該硬頸（5)中防漏地裝設了在導管（41 )中終止 的配施頭（2)，用於將該液體排出該瓶，其特徵在於此 裝置包含插在所述頭的本體（3)中的微孔墊（6)，該 微孔塾（6)橫越在大橫截面區域的液體分配室（31)上 游的所述瓶子（1)以及所述導管（41)之間的液體通道 的橫截面區域，該大橫截面區域形成於所述墊子（6)的 下游表面（63)以及所述所述排出導管（41)之間的所 述本體（3)中，所述墊子（6)由對於該液體為鈍性的 材料製成，且能夠產生壓頭損失，該壓頭損失依據每次 的動作而藉由該瓶子（1)中產生的壓力來調節經由它驅 動的液體流，以減少其體積，且所述分配室（31)具有 夠大的體積以容納已經過所述墊子（6)的液體，所述瓶 子（1)以可縱向變形的摺箱（12)的形式由圓柱整體形 狀的壁為界’該摺箱（12)在堅硬的橫截底部（13)中 結束，並與任何可能進入以取代所排出液體的空氣隔離 10014733^單編號A0101 第5頁/共40頁 第5頁/共40頁 1013146740-0 201231117 已做出了許多努力以設計出可容納並配施液體藥劑以用 於多重劑量投藥的較簡單裝置。例如，最近授權的美國 專利編號US 7, 338, 228揭露了一種用於容納在貯存容器 中的液體產品的塗藥器裝置，所述裝置包含用於關閉所 述容器開口的蓋子；通過所述蓋子的至少一移動管道， 用於將所述液體產品毛細管移動至所述容器之外與其接 觸的可弄濕表面，所述毛細管移動管道的一下游端朝向 所述蓋子的外側開口；用於從所述容器抽出所述液體產 品的抽出管，在所述容器中，所述移動管道的上游端打 開且所述容器被建構，以經由毛細管效應而對抗重力作 用’而保留從所述容器抽出的決定劑量的液體產品；以 及具有一層材料的可移除帽子，該材料可吸收所述蓋子 外之上的液體，但不能吸收該至少一移動管道以及該抽 出管内的液體。 另一個美國專利申請案US201 00 1 452871揭露了用於容納 以及配施醫藥液體的組合的類型，包含： 用於容納液體的容器（4) ’該容器（4)具有頸部（14 );配置在該頸部（14)端部的配施點滴器端配件（6) ，該端配件（6)以及該容器（4)允許藉由擠壓在一手 手指之間的該容器（4 )來逐滴配施該液體；以及用於關 閉該谷器（4)的蓋子（8) ’被提供來旋鎖於該頸部（ 14)上；其特徵在於該蓋子（8)以及該頸部（14)具有 女王裝置’預防s玄蓋子（8)只藉由施加鬆開的扭矩而鬆 開’並當一起施加額外的動作與用於鬆開該蓋子（8 )的 扭矩時，允許該蓋子（8)鬆開。 10〇14733#單編號A0101 第6頁/共40頁 1013146740-0 201231117 [0003]201231117 VI. Description of the Invention: TECHNICAL FIELD OF THE INVENTION [0001] The present invention relates to a device suitable for dispensing multiple doses of a liquid medicament while maintaining the sterility of a container having the liquid medicament therein. [Prior Art] [0002] For many years, the main method of medical treatment of ocular disorders has been the administration of various liquid drugs via topical administration. Typically, the dispensers are available in a variety of sizes and dispensing drip shapes, but without the reproducible standard drop size determined by the tip of the dropper (applicator). Moreover, when attempting to use topical preparations, such as ophthalmic drops, the most common problem experienced by typical patients is the problem of wasting. When the drip is introduced into the eye, the average lower conjunctival cavity retains only one-quarter to one-half of the standard drip. The rest is not drained through the cheeks, or discharged by the lacrimal gland system. In addition to the problem of dispensing a non-uniform size drip, there are also problems associated with the use of preservatives in the liquid medicament. For example, "gasified benzalkonium chloride" (a known preservative) has been reported to cause damage to the cornea in chronic treatment [Cha et a 1 in Clin Experiment Ophthalmol. 2004 Apr; 32 ( 2 ) :180-4]. It is now well known that preservatives have been linked to side effects as well as allergic reactions. Therefore, it can be said that there is an unmet need to prevent the waste problem mentioned above and to provide the feasibility of including a preservative-free agent. An ideal device wherein the device is designed to maintain the sterility of the medicament. Reviewing the prior art, it can be seen that many efforts have been made to design a device suitable for delivering liquid medicaments for topical administration. For example, European Patent Application No. EP 1 779 832 describes a squeezing container comprising a container body for containing a liquid and opening to the open end of the container body 1()() 14733#单号 A0101第4页/ a neck of 40 pages 1013146740-0 201231117, wherein the container body has a bellows that contracts and expands in a direction substantially perpendicular to a direction in which the liquid is discharged through the neck. The bellows has a direction toward the transport direction a plurality of folded portions arranged, each of the folded portions being spaced apart from each other in a contraction direction, and a width of the folded portion is made at a convex edge in a direction perpendicular to the contraction direction to decrease from the middle to the both ends in the contraction direction, And the width of the folded portion is made at the concave edge in a direction perpendicular to the contraction direction to decrease from the middle to both ends in the contraction direction. US Patent No. US 6,336,571 describes a device for packaging a liquid to be dispensed dropwise, comprising a resilient wall bottle (1) that can be manually deformed to face the hard neck (5) Gradually reducing its internal volume' in the hard neck (5) is provided with a dispensing head (2) terminating in the conduit (41) for discharging the liquid out of the bottle, characterized in that the device comprises a microporous pad (6) inserted in the body (3) of the head, the microporous (6) traversing the bottle (1) upstream of the liquid distribution chamber (31) in the large cross-sectional area a cross-sectional area of the liquid passage between the conduits (41), the large cross-sectional area being formed on the downstream surface (63) of the mat (6) and the body between the discharge conduits (41) In (3), the mat (6) is made of a material that is blunt to the liquid, and is capable of generating a head loss that is generated by the bottle (1) according to each movement. Pressure to regulate the flow of liquid driven therethrough to reduce its volume, and the dispensing chamber (31) has a large enough volume to The liquid has passed through the mat (6), and the bottle (1) is bounded by a wall of a cylindrical overall shape in the form of a longitudinally deformable bellows (12). The bellows (12) is in a hard cross section. Ends in the bottom (13) and is isolated from any air that may enter to replace the discharged liquid. 10014733^Single number A0101 Page 5 of 40 Page 5 / Total 40 pages 1013146740-0 201231117 Many efforts have been made to A simpler device that accommodates and dispenses a liquid medicament for multiple dose administration is devised. An applicator device for containing a liquid product contained in a storage container, the device comprising a lid for closing the opening of the container, through the said US Pat. No. 7,338,228 At least one moving pipe of the cover for moving the liquid product capillary to a wettable surface in contact with the outside of the container, a downstream end of the capillary moving pipe opening toward an outer side of the cover; The container withdraws an extraction tube of the liquid product, in which the upstream end of the moving conduit is opened and the container is constructed to resist gravity action via capillary action while retaining the withdrawal from the container a dose-determining liquid product; and a removable cap having a layer of material that absorbs liquid above the lid but does not absorb the at least one moving conduit and the liquid within the withdrawal tube. Another type of combination for accommodating and dispensing a medical fluid, comprising: a container for holding a liquid (4) 'the container (4) having a neck (14); another configuration, US Pat. No. 1,201, 452, 871; At the end of the neck (14) is fitted with a dropper end fitting (6), the end fitting (6) and the container (4) are allowed to be squeezed by the container (4) between the fingers of one hand Drip dispensing the liquid; and a lid (8)' for closing the bar (4) is provided to be screwed onto the neck (14); characterized by the lid (8) and the neck (14) ) having the queen device 'preventing the sinus cover (8) only by releasing the released torque' and allowing the cover when the additional action is applied together with the torque for releasing the cover (8) )release. 10〇14733#单号A0101 Page 6 of 40 1013146740-0 201231117 [0003]
Ο [0004] 因此，顯而易見的是，僅管有數種嘗試，仍有需要創造 出人體工學的多重劑量裝置，該裝置可容納並配施無菌 液體藥劑’同時維持該藥劑的無菌。因此，總是需要可 避免使用防腐劑（防腐劑為維持該液體藥劑的無菌所需 )以及可配施預設體積的液體藥劑的裝置。本發明的裝 置達成了這些目的。 【發明内容】 本發明描述了 一種適用於配施多重劑量液體藥劑的裝置 ，該裝置包含 a) 其中具有液體藥劑的容器，包含至少一可折疊壁（3 ) b) 連接至推鈕（8)的旋轉活塞（7)以及 c) 鎖定裝置 其中在按壓該推鈕（8)之後，該旋轉活塞（7)旋轉並 從第一位置橫越至橫越位置，導致該容器可折疊壁（3) 的預設壓縮，以配施預設體積的該液體藥劑，以及其中 藉由該鎖定裝置將該旋轉活塞（7)鎖定而不能回到該第 一位置，藉此預防空氣進入該容器，以在該容器（3)内 維持無菌環境。 【實施方式】 A]本發明描述了一種適用於配施多重劑量的液體藥劑的 裝置，該裝置包含 a) 其中具有液體藥劑的容器，包含至少一可折疊壁（3 ) b) 連接至推鈕（8)的旋轉活塞（7)，以及 10014733#單編號 A0101 第7頁/共40頁 1013146740-0 201231117 C] 鎖定裝置 其中在按壓該推鈕（8)之後，該旋轉活塞（7)旋轉並 從第一位置橫越至橫越位置，導致該容器（3)的可折疊 壁的預設壓縮，以配施預設體積的液體藥劑，以及其中 藉由該鎖定裝置將該旋轉活塞（7)鎖定而不能回到該第 一位置，藉此預防空氣進入該容器中，以維持該容器（3 )内的無菌環境。 B] —種如A中所述的裝置，其中該旋轉活塞（7)包含外 部齒輪齒（24)、内部螺紋（25)以及在一端的平坦表 面（26)與球形表面（27)的組合。 c] 一種如β中所述的裝置，其中具有可折疊壁的容器（3 )的表面（28)停留在該旋轉活塞（7)的該平坦表面（ 26)以及球形表面（27)上。 D] —種如Α中所述的裝置’其中該旋轉活塞（？）被裝設 在具有外部螺紋（30)的螺紋物件（9)上。 E] —種如D中所述的裝置，其中該旋轉活塞（？）被裝設 在具有外部螺紋（30)的固定螺栓（9)的螺紋物件上。 F] —種如E中所述的裝置，其中該固定螺栓的外部螺紋 (3〇)夾住該旋轉活塞（7)的内部螺紋（25)。 G] —種如A中所述的裝置，其中該推鈕（8)利用具有漸 細尖端（43)的收縮臂（29)而連接至該旋轉活塞⑺ ，其中當按壓該推鈕（8)時，該推鈕（8)沿著每個提 供於該外部套子⑷以及（5)中的引導轨道（15)滑 動，其中該漸細尖端（43)符合該旋轉活塞（7)的連續 外部齒輪齒（24)中，且該推叙⑻推動該旋轉活塞（ 7)的该外部齒輪齒（24)，導致該旋轉活塞（7)的旋 10014733#單編號删1 第8頁/共4〇頁 1013146740-0 201231117 轉移動。 Η] —種如A中所述的裝置，其中被配施的液體藥劑的體 積取決於該旋轉活塞（7)橫越的距離。 I] 一種如A中所述的裝置，其中該鎖定裝置包括棘輪臂 (18) ’該棘輪臂（18)為固定外部套子（5)的一部分 J] 一種如Η中所述的裝置，其中該棘輪臂〇8)與該旋 轉活塞（7)的該外部齒輪齒（24)鎖固，以限制該旋轉 活塞（7)以單一方向旋轉移動。 Κ] 一種如Α中所述的裝置，其中該可折疊壁為摺箱或肋 或管或氣球的形式。 L] 一種如A中所述的裝置，其中該液體藥劑的預設體積 為大約50微升》 本發明具有可折疊壁的容器（3)可用於將美容或藥劑液 體投藥至使用者。本發明的容器以滴液的形式配施微升 量的液體。 Q 本發明的裝置用於傳遞藥劑至體腔，例如使用者的眼睛 、耳朵、鼻子以及諸如此類。在本發明的特定較佳具體 實施例中，本發明的裝置用以將藥劑投藥至病患的眼睛 。典型地，該裝置用以將眼科藥劑傳遞至使用者。由於 該裝置的獨特結構，該藥劑不需加入作為防腐劑的化合 物。由於移動的限制，在擠壓用於配施液體藥劑的容器 之後’外部空氣不能進入該容器内部。因此，本發明的 裝置也可稱為「無防腐劑的液體藥劑」遞送裝置。 根據本發明，該裝置適用於配施多重劑量的液體藥劑， 該裝置包含 10014733#單編號A0101 第9頁/共40頁 1013146740-0 201231117 a) 其中具有液體藥劑的容器，包含至少一可折疊壁（3 ) b) 連接至推鈕（8)的旋轉活塞（7)，以及 c) 鎖定裝置 其中在按壓該推鈕（8)之後，該旋轉活塞（7)旋轉並 從第一位置橫越至橫越位置，導致該容器（3)可折疊壁 的預設壓縮，以配施預設體積的液體藥劑，以及其中藉 由該鎖定裝置將該旋轉活塞（7)鎖定而不能回到該第一 位置’藉此預防空氣回到該容器内，以維持該容器内的 無菌環境。 在一個特定的具體實施例中，利用包含收縮臂（29)的 推紐（8)旋轉該旋轉活塞（7)，該收縮臂（29)具有 設計成用以符合該旋轉活塞的兩個連續外部齒輪齒 (24 )之間凹處的漸細尖端（43 )。 特別是，在一個具體實施例中，該旋轉活塞（7)被裝設 在螺紋物件上，例如具有外部螺紋（3〇)的固定螺栓（9 )。該旋轉活塞（7)包含外部齒輪齒（24)、内部螺紋 (25)以及在一端的平坦表面（26)與球形表面（27) 的組合。 根據本發明，該固定螺栓（9)的外部螺紋（3〇)夹住該 旋轉活塞⑺的内部螺紋（25)。該旋轉活塞⑺橫 越的距離決定被配施的液體藥劑的體積。最後旋轉移動 該旋轉活塞⑺控制該容器（3)的往上移動。 在-個具體實施例中’本發明的裝置包括作為鎖定裝置 的彈簧。該彈簧可為臂的形式，該臂容納在外部套子上 ，以限制該旋轉活塞⑺以單一方向旋轉移動。 10014733^^'^^ A〇101 第 10 頁 / 共 40 頁 1013146740-0 201231117 在個具體實施例中，本發明的裝置可用於藉由先握住 該裝置並旋轉蓋子⑴以打開而遞送液體藥齊卜該裝置 應被握住’使得推紐（8)面對使用者，拇指放在推紐（ 8)上，且手指靠著橢圓凹處（22)放置。橡皮環（1〇) 應被放在較低的眼蓋上，且應被往下拉。需要將頭傾斜 ，並需要以拇指按壓該推鈕（8)。在每隻眼睛中配施所 需劑量的藥劑之後，將該裝置取離眼睛，並將蓋子丨放回 其原本的位置中，並將其旋轉以關閉。 在本發明的一個具體實施例中，具有可折養壁的容器（3 )(如第29、30及31圖中所示）為堅硬的頸部部分（π )以及壁上摺箱形彈性部分（23)的整合，該頸部部分 (37)以及壁上摺箱形彈性部分（23)由該槽〇3)分 開。在某些其他的具鱧實施例中，該具有可折疊壁的容 器（3)可為摺箱、肋、管或氣球的形式。在所有的這些 具體實施例中’重要的是’該容器的形狀允許該容器（3 )的折疊，而不讓使用者覺得相當費力。喷嘴（2)可被 安裝在該容器（3)上，或兩者可利用本技術領域已知的 方式結合在一起，例如藉由干涉配合或熱封，或藉由谭 接在一起，或可整合製造，或諸如此類。 在本發明的一個具體實施例中，該裝置包含 i)其中具有液體藥劑而為瓶子形式的容器，該容器包含 摺箱形式（3)的至少一可折疊壁 ii) 連接至推鈕（8)的旋轉活塞（7) iii) 類似彈簧的棘輪臂形式的鎖定裝置。 其中在按壓該推鈕（8)之後，該旋轉活塞（7)旋轉並 從第一位置橫越至橫越位置’導致該容器（3)的可折養 10014733#單編號A0101 第11頁/共40頁 1013146740-0 201231117 土的預设壓縮，以配施預設體積的液體藥劑，以及其中 藉由該鎖定裝置鎖定該旋轉活塞（7)而不能回到該第一 位置，藉此預防空氣回到該容器中，以維持該容器（3) 内的無菌環境。 使用於容器的材料可為可變形的材料，例如低密度聚乙 烯、PET、PP以及諸如此類。 根據本發明的裝置包括可為下述類型的「鎖定裝置」， 例如自由輪機制（實質上類似於棘輪機制，但機械元件 不同，效果相同）或機械性單一方向摩擦阻力，或藉由 使用具有止回_水力或氣動裝置，以限制往回移動， 或像是在祕㈣正賴合的布的縫合_中使用進給 齒的滴注式卿。這藉由以使其在該她⑻向前敲擊 期間與該旋轉活塞⑺的外部齒輪齒（24)接觸，且在 該推紐⑷反向敲擊期間不接觸的方式引導該推紐（8 )中收縮（類似彈簧）臂（29)的移動而完成。這裡， 該#作為進給齒（feed dGg)」，且不需為類似彈菁 的。然而’可了解的是，該較裝置不限於上述列出的 類型，且可為符合如同該裝置設計的任何類型，從而在 該驅動臂边使其朝該容器⑴可折疊壁㈣向移動之後 :該旋轉活塞⑺被受限而不能回到其原本的位置。 10014733#單編號 A0101 第12頁/共40頁 旋轉活塞（7)包含外部齒輪齒（⑷、内部螺紋（25) 以及在-端平坦表面（26)與球形表面（⑺的組合。 其位在螺紋物件上，例如具有外部螺紋（3Q)的固定螺 栓⑻。該旋轉活塞⑺藉由㈣該推紐（8)以及其 漸細尖端而旋轉’該旋轉活塞⑺利用其收縮臂（29)、 〇橫〇越’其漸Μ端符合騎轉絲⑺連㈣部齒輪齒 1013141 201231117 (24 )之間的凹處。 在該推鈕⑷的-次敲擊中，該旋轉活塞⑺橫越的 距離相應於將被配施的液體藥劑的預設體積。在本發明 的具體實施例中，該預設體積為大約5〇微升。可能要注 意的是，減轉活塞（7)撗越的距離的定量安排可只在 該裝置的製細段完成，且使用者不能改變將被配施的 體積設定。料實避㈣使肖者玩弄錄置，藉此完全 避免不想要的’即額外或較少量體積的液體藥劑遞送的 可能性。因此’該使用者不能做出任何種類在液體藥劑 剤量方面的自行㈣。這續實是該裝置的其中一個具創 造性的特徵。因此，如果指示該使用者施用固定數量的 滴液，可達成最佳的醫療，而不損害該裝置。 本發明的裝置，包括，-或更多的鎖定裝置以鎖定該旋 轉活塞⑺’以避免從橫越位置回到第—位置。該鎖定 褒置包括具有類似彈簧作用的物件，例如類似片彈黃的 棘輪臂（18)。然而’可了解的是，該鎖定裝置可為任 何形狀，且只要發揮彈簧效果，將提供鎖定作用。該彈 簧可為彈性臂或桿子或平坦突出物等等的形式。該鎖定 裝置維持與該旋轉活塞（7)的外部齒輪齒（24)持續接 觸，使得當該旋轉活塞（7)旋轉時，該齒滑過該鎖定裝 置°當該鎖定裝置與該旋轉活塞（7)的該外部齒輪齒（ 24)鎖定而非滑過時，預防了反向的動作，因為在該旋 轉活塞（7)的反方向中，該鎖定裝置不能被收縮。 雖然已在特定具體實施例以及應用的方面描述了本發明 ，本領域具一般技藝的人員按照此教導，可產生額外的 具體實施例以及修飾’而不悖離所主張之發明的精神或 顏“單編號靡1 第13頁/共40頁 1013146740-0 201231117 超過其範圍。應強調的是，上述的本發明具體實施例， 特別是任何「較佳的」具體實施例，僅為完成本發明的 可能範例，僅提出用於清楚地了解本發明的原理。因此 ，要了解的是，以範例的方式提出本文中的圖式以及描 述，以幫助理解本發明，且不應理解為限制其範圍。 圖式的詳細描述 參照下述圖式可更了解本發明的許多方面。圖式中的元 件不一定按比例，基於清楚地描繪本發明的原理，反而 是使用了強調的方式。此外，圖式中，相似的元件符號 指出了從頭到尾數個視圖的相應部分或特徵的部分。 蓋子組合（1) ··蓋子組合1(如第32、33及34圖中所示 )由放在容器蓋子Ι-b頂部上的外部蓋子Ι-a組成。其以 讓使用者容易移除蓋子的方式設計。該外部蓋子Ι-a可安 裝於該容器蓋子卜b上，或兩個蓋子可利用本技術領域已 知的方式結合在一起，例如藉由熱封或藉由焊接在一起 或諸如此類。或者，使用覆蓋喷嘴的單一蓋子。該蓋子 主要的功能是保護該喷嘴以及該容器内容物，以避免曝 露至外部環境。本發明蓋子的另一個功能是在第一次投 藥藥劑之前，藉由該蓋子的扭轉動作而藉由產生扭矩來 幫助打破該容器的密封，以使該容器立即可由使用者進 行後續的使用。該外部蓋子1-a (如第32、33及34圖中 所示）的形狀提供了人體工學的蓋子手把，使得扭轉該 蓋子以產生足以打破該容器密封的扭矩的工作以及在每 次投藥該藥劑之前移除該蓋子的工作變得更容易。 喷嘴（2):設計該喷嘴2 (如第14、15及16圖中所示） ，使其結合該容器（3)可折疊壁的摺箱形彈性部分（23 1001473#單編號 A_ 第14頁/共40頁 1013146740-0 201231117 )、旋轉活塞（7)、推鈕（8)以及固定螺栓（9)而配 施單滴微升量的液體。本發明的喷嘴2作用以產生並配施 將被配絶的液體微升大小的滴液。在其配施端的喷嘴尖 端具有内部直徑以及外部直徑’且該尖端藉由從該配施 尖端逐漸變小至該喷嘴（2)中隙缝的毛細管而連接至該 喷嘴（2)内的隙縫。該隙缝以及該噴嘴尖端的直徑結合 將被投藥之液體的表面張力導致微升大小滴液的形成。 該隙縫以及該噴嘴尖端的直徑可不同，以對於不同表面 張力的液體產生固定大小的微升體積滴液。該喷嘴（2) 可由疏水性材料製成，或其可使用疏水性物質塗層，以 減少該尖端的濕潤，並避免液體集結而形成較大的滴液 〇 具有可折疊壁的容器（3):本發明具有可折疊壁的容器 (3)(如第29、30及31圖中所示）為堅硬的頸部部分（ 37)以及壁上摺箱形彈性部分（23)的整合，該頸部部 分（37)以及壁上摺箱形彈性部分（23)由槽（13)分 ◎ 開。部分（23 )的形狀可不同於擅箱，只要其允許該容 器（3)的折疊而不使使用者覺得需要費相當大的勁。該 噴嘴（2)可安裝於該容器（3)上，或兩者可利用本技 術領域已知的方式結合在一起，例如藉由干涉配合或熱 封或藉由焊接結合在一起，或可整合地製成或諸如此類 〇 外部套子-左半部（4)以及外部套子-右半部•圍 繞整合摺箱容器（3)、旋轉活塞（7)以及固定螺栓 )的外部套子（4)以及（5)(如第7、8、9、1〇、n 、12及13圖中所示）存在於該裝置中，且通常由堅硬的 10014733#單編號A01〇l 第15頁/共40頁 1013146740-0 201231117 材料製成’且每個具有半橢圓形槽（10)，用於容納該 推紐（8)。每個外部套子（4)以及（5)也包含另一個 半擴圓形槽（17)，用於配合液面指示器（6)。 在推知（8)兩侧上提供有槽（14)，其沿著每個被提供 在該外部套子（4)以及（5)中的引導軌道（15)引導 該推紐（8)。在該引導軌道（15)的末端，有被提供在 每個外部套子（4)以及（5)中的停止面（16)。 每個具有半圓形挖空部分（12)的每個半圓形肋（11) 被提供在槽（18)上的外部套子（4)以及（5)的壁中 ’以襯邊地（mattingly)符合整合摺箱容器（3)中的 槽（13)。該外部套子（4)以及（5)的每個肋（n) 以及該整合摺箱容器（3)中的該槽（13)有用以在該外 部套子（4)以及（5)中精確地定位以及校直整合摺箱 容器（3) ’並將該整合摺箱容器（3)鎖固於適當位置 ，以避免該整合摺箱容器（3)在該外部套子（4)以及 (5)有不必要的移動。 1013146740-0 外部套子-右半部（5)提供有類似彈簧的棘輪臂（18) ，以限制旋轉活塞（7)只以一個方向旋轉移動。這確保 容器（3)的可折疊壁將不展開而讓空氣進入其内。在該 外部套子（4)以及（5) —端處的每個非圓形（19)( 可為半六角形）、圓形（20)以及肋（21)的組合穩固 地保持固定螺栓（9)在適當位置。外部套子（4)以及 (5)已提供有每個在外部表面上的橢圓形凹處（22)， 以引導使用者以正確的方式握住該裝置。外部套子 以及（5)兩者都可藉由像是咬合、旋鎖或類似的方法固 定在一起。提供在外部套子（4)以及（5)中的挖空部 10014733#單編號A〇1〇l 第16頁/共40頁 201231117 分（38)以及（39)作為用以檢查容器蓋子卜b防擅改的 窗口。提供在外部套子（4)以及（5)中的挖空部分（ 4〇)、（41)允許使用者持續監視喷嘴尖端的損害、清 潔度等等。 液面指示器（6):安裝在該外部套子（4)以及（5)上 的液面指示器（6)(如第26、27及28圖中所示）為透明 的元件。該液面指示器是用以看見有效期結束功能的窗 口。在有效階段結束時，使用者將看見全紅的旗號，以 指示該藥劑被完全消耗光。 〇 旋轉活塞（7):旋轉活塞7 (如第23、24及25圖中所示 )是外部齒輪齒（24)以及内部螺紋（25)的組合。外 部齒輪齒（24)以及内部螺紋（25)的輪廓被設計成使 得推鈕（8)的每次敲擊造成配施預定大小的滴液。在該 旋轉活塞（7) —端的平坦表面（26)與球形表面（27) 的另一個組合與該整合摺箱容器（3)的表面（28)接觸 。该平坦表面（26)軸向地推擠容器表面（28)，以擠 ❹ Μ具有可折疊壁的容器⑻，以配施預定大小的滴液。 «玄球形表面（27)夾住容器表面（28)，因此限制該容 器（3)的任何側向移動。最後旋轉移動該旋轉活塞（7 )控制該容器（3)的往上移動。 推紐（8):推紐（8)(如第17、18及19圖中所示）被 設計成用以當被按壓時旋轉旋轉活塞（7)。當按壓該推 鈕（8)時，推鈕（8)沿著每個提供在該外部套子（4) 以及（5)中的引導軌道〇5)滑動的同時，具有漸細尖 端（43)的收縮臂（μ)因此導致該旋轉活塞（了）的旋 轉移動其中該漸細尖端（43)符合該旋轉活塞（？）連 10014733^^^ Α〇101 第 17 頁 / 共 40 頁 1013146740-0 201231117 續外部齒輪齒（24)之間的凹處。當推鈕（8)的表面（ 42)碰到每個提供在外部套子（4)以及（5)中的停止 面（16 )時’推鈕（8 )的移動被限制。 具有螺紋的物件，例如固定螺检（9 ):含在固定螺栓（ 9)的圓盤（32)、（33)中的部分（如第2〇、21及22 圖中所示）被穩固地保持在每個提供在外部套子（4 )以 及（5)上的非圓形（19)(可為半六角形）、圓形（2〇 )以及肋（21)内。固定螺栓（9)的外部螺紋（3〇)維 持住旋轉活塞（7)的内部螺紋（25)。當該推鈕（8) 被使用者釋放時，與該固定螺栓（9)整合的彈簧（31) 的表面（34)將推紐（8)推回β 橡皮環（10):橡皮環1〇(如第35、36及37圖中所示） 為分別位在外部套子（4)以及（5)頂端（35)、（36 )的橡皮元件。 【圖式簡單說明】 [00°5] 第1圖：分解等角視圖 第2圖：完整組合前視圖 第3圖：完整組合側視圖 第4圖：完整組合等角視圖 第5圖.完整組合俯視圖 第6圖：完整組合截面圖 第7圖：外部套子（右半部）：前視圖 第8圖：外部套子（右半部）：側視圖 第9圖：外部套子（右半部）：等角視圖-1 第10圖：外部套子（右半部）：等角視圖一2 第11圖：外部套子（左半部）：前視圖 _4733#早編銳應〇1 第18頁/共4〇頁 1013146740-0 201231117 第12圖：外部套子（左半部）：側視圖 第13圖：外部套子（左半部）：等角視圖 第14圖：喷嘴：前視圖 第15圖：喷嘴：俯視圖 第16圖：噴嘴：等角視圖 第17圖：推鈕：前視圖 第18圖：推紐：側視圖 第19圖：推鈕：等角視圖 第20圖：固定螺栓：側視圖 第21圖：固定螺栓：俯視圖 第22圖：固定螺栓：等角視圖 第23圖：旋轉活塞：側視圖 第24圖：旋轉活塞：俯視圖 第25圖：旋轉活塞：等角視圖 第26圖：液面指示器：前視圖 第27圖：液面指示器：俯視圖 第28圖：液面指示器：等角視圖 第29圖：整合的摺箱容器：前視圖 第30圖：整合的摺箱容器：俯視圖 第31圖：整合的摺箱容器：等角視圖 第32圖：外部蓋子：前視圖 第33圖：外部蓋子：俯視圖 第34圖：外部蓋子：等角視圖 第35圖：橡皮環：前視圖 第36圖：橡皮環：俯視圖 第37圖：橡皮環：等角視圖 10014733#單編號 A0101 第19頁/共40頁 1013146740-0 201231117 【主要元件符號說明】 [0006] 1-a 外部蓋子 Ι-b 容器蓋子 2 喷嘴 3 具有可折疊壁的容器 4 外部套子左半部 5 外部套子右半部 6 液面指示器 7 旋轉活塞 8 推紐 9 固定螺栓 10 橡皮環 11 半圓形肋 12 半圓形挖空部分 13、14 槽 15 引導執道 16 停止面 17 半橢圓形槽 18 棘輪臂 19 非圓形 20 圓形 21 肋 22 橢圓形凹處 23 摺箱形彈性部分 24 外部齒輪齒 25 内部螺紋 丽473#單編號謝01 第20頁/共40頁 1013146740-0 201231117 2 6 平坦表面 27 球形表面 28 容器表面 29 收縮臂 30 外部螺紋 31 彈簧 32、33 圓盤 34 表面 3 5頂端 36 外部套子的頂端 37 堅硬的頸部部分 38、39、40、41 挖空名P分 42 表面 43 符合旋轉活塞兩個連續外部齒輪齒之間凹處的漸細 尖端[0004] Thus, it will be apparent that there are a number of attempts to create an ergonomic multi-dose device that can accommodate and dispense a sterile liquid medicament while maintaining the sterility of the medicament. Therefore, there is always a need to avoid the use of preservatives (preservatives required to maintain the sterility of the liquid medicament) as well as devices that can be dispensed with a predetermined volume of liquid medicament. The device of the present invention achieves these objectives. SUMMARY OF THE INVENTION The present invention describes a device suitable for dispensing a multi-dose liquid medicament comprising a) a container having a liquid medicament therein, comprising at least one foldable wall (3) b) connected to a push button (8) Rotating piston (7) and c) locking device wherein after pressing the push button (8), the rotary piston (7) rotates and traverses from the first position to the traverse position, resulting in the container collapsible wall (3) Pre-compressed to dispense a predetermined volume of the liquid medicament, and wherein the rotary piston (7) is locked by the locking device and cannot be returned to the first position, thereby preventing air from entering the container to A sterile environment is maintained within the container (3). [Embodiment] A] The present invention describes a device suitable for dispensing multiple doses of a liquid medicament, the device comprising a) a container having a liquid medicament therein, comprising at least one foldable wall (3) b) connected to a push button (8) Rotating Piston (7), and 10014733#Single Number A0101 Page 7/Total 40 Page 1013146740-0 201231117 C] Locking device wherein after pressing the push button (8), the rotary piston (7) rotates Traversing from the first position to the traverse position results in a predetermined compression of the collapsible wall of the container (3) to dispense a predetermined volume of liquid medicament, and wherein the rotary piston (7) is secured by the locking device Locked and not returned to the first position, thereby preventing air from entering the container to maintain a sterile environment within the container (3). B] - A device as described in A, wherein the rotary piston (7) comprises an outer gear tooth (24), an internal thread (25) and a combination of a flat surface (26) at one end and a spherical surface (27). c] A device as described in β, wherein the surface (28) of the container (3) having the foldable wall rests on the flat surface (26) of the rotary piston (7) and the spherical surface (27). D] - a device as described in Α where the rotary piston (?) is mounted on a threaded object (9) having external threads (30). E] - A device as described in D, wherein the rotary piston (?) is mounted on a threaded object of a fixing bolt (9) having an external thread (30). F] - A device as described in E, wherein the external thread (3 〇) of the fixing bolt clamps the internal thread (25) of the rotary piston (7). G] - a device as described in A, wherein the push button (8) is connected to the rotary piston (7) by means of a contracting arm (29) having a tapered tip (43), wherein when the push button (8) is pressed The push button (8) slides along each of the guide rails (15) provided in the outer sleeves (4) and (5), wherein the tapered tip (43) conforms to the continuous outer gear of the rotary piston (7) In the tooth (24), and the derivation (8) pushes the outer gear tooth (24) of the rotary piston (7), causing the rotary piston (7) to rotate 10014733# single number deletion 1 page 8 / total 4 pages 1013146740-0 201231117 Turn to move.装置] A device as described in A, wherein the volume of liquid medicament dispensed depends on the distance traversed by the rotary piston (7). I] A device as described in A, wherein the locking device comprises a ratchet arm (18) 'the ratchet arm (18) is part of a fixed outer sleeve (5) J] a device as described in The ratchet arm 8) is locked with the outer gear teeth (24) of the rotary piston (7) to limit the rotational movement of the rotary piston (7) in a single direction.装置] A device as described in Α, wherein the foldable wall is in the form of a bellows or rib or tube or balloon. L] A device as described in A, wherein the predetermined volume of the liquid medicament is about 50 microliters. The container (3) having a foldable wall of the present invention can be used to administer a cosmetic or pharmaceutical liquid to a user. The container of the present invention dispenses a microliter of liquid in the form of a drip. Q The device of the present invention is used to deliver a medicament to a body cavity, such as the user's eyes, ears, nose, and the like. In a particularly preferred embodiment of the invention, the device of the invention is for administering a medicament to the eye of a patient. Typically, the device is used to deliver an ophthalmic agent to a user. Due to the unique structure of the device, the agent does not require the addition of a compound as a preservative. Due to the restriction of movement, external air cannot enter the inside of the container after squeezing the container for dispensing the liquid medicament. Thus, the device of the present invention may also be referred to as a "preservative-free liquid medicament" delivery device. According to the invention, the device is suitable for dispensing multiple doses of liquid medicament, the device comprising 10014733#single number A0101, page 9 / total 40 pages 1013146740-0 201231117 a) a container having a liquid medicament, comprising at least one collapsible wall (3) b) a rotary piston (7) connected to the push button (8), and c) a locking device in which the rotary piston (7) rotates and traverses from the first position after pressing the push button (8) Traverse position, resulting in a predetermined compression of the collapsible wall of the container (3) to dispense a predetermined volume of liquid medicament, and wherein the rotary piston (7) is locked by the locking device and cannot be returned to the first The location 'by this prevents air from returning to the container to maintain a sterile environment within the container. In a particular embodiment, the rotary piston (7) is rotated by a push button (8) comprising a contracting arm (29) having two consecutive outer portions designed to conform to the rotary piston A tapered tip (43) between the gear teeth (24). In particular, in one embodiment, the rotary piston (7) is mounted on a threaded article, such as a mounting bolt (9) having an external thread (3 turns). The rotary piston (7) comprises an outer gear tooth (24), an internal thread (25) and a flat surface (26) at one end in combination with a spherical surface (27). According to the invention, the external thread (3) of the fixing bolt (9) clamps the internal thread (25) of the rotary piston (7). The distance over which the rotary piston (7) traverse determines the volume of liquid medicament being dispensed. Final rotational movement The rotary piston (7) controls the upward movement of the container (3). In a particular embodiment the device of the present invention includes a spring as a locking device. The spring may be in the form of an arm that is received on the outer sleeve to limit rotational movement of the rotary piston (7) in a single direction. 10014733^^'^^ A〇101 Page 10 of 40 1013146740-0 201231117 In a specific embodiment, the device of the present invention can be used to deliver a liquid drug by first holding the device and rotating the lid (1) to open The device should be held so that the push button (8) faces the user, the thumb is placed on the push button (8), and the finger is placed against the elliptical recess (22). The rubber ring (1〇) should be placed on the lower eye cover and should be pulled down. The head needs to be tilted and the push button (8) needs to be pressed with the thumb. After dispensing the desired dose of medicament in each eye, the device is removed from the eye and the lid is placed back into its original position and rotated to close. In a particular embodiment of the invention, the container (3) having a retrievable wall (as shown in Figures 29, 30 and 31) is a rigid neck portion (π) and a box-shaped elastic portion on the wall. In the integration of (23), the neck portion (37) and the wall-folded box-shaped elastic portion (23) are separated by the groove 3). In certain other embodiments, the container (3) having a foldable wall may be in the form of a bellows, rib, tube or balloon. In all of these specific embodiments, it is important that the shape of the container allows the container (3) to be folded without the user feeling quite laborious. The nozzle (2) can be mounted on the container (3), or both can be joined together by means known in the art, such as by interference fit or heat sealing, or by tanning together, or Integrated manufacturing, or the like. In a particular embodiment of the invention, the device comprises i) a container in the form of a bottle having a liquid medicament therein, the container comprising at least one foldable wall ii) in the form of a bellows (3) connected to the push button (8) Rotating piston (7) iii) Locking device in the form of a spring-like ratchet arm. Wherein after the push button (8) is pressed, the rotary piston (7) rotates and traverses from the first position to the traverse position 'causing the container (3) to be circumscribed 10014733# single number A0101 page 11 / total 40 pages 1013146740-0 201231117 The preset compression of the soil to dispense a preset volume of liquid medicament, and wherein the rotary piston (7) is locked by the locking device and cannot return to the first position, thereby preventing air back Into the container to maintain a sterile environment within the container (3). The material used for the container may be a deformable material such as low density polyethylene, PET, PP, and the like. The device according to the invention comprises a "locking device" of the type described below, for example a freewheel mechanism (substantially similar to a ratchet mechanism, but with different mechanical elements, the same effect) or a mechanical single direction frictional resistance, or by use of Stop _ hydraulic or pneumatic device to limit the movement back, or like the infusion of the feed tooth in the stitching of the cloth (4). This is guided by contacting the outer gear teeth (24) of the rotary piston (7) during the forward stroke of the her (8) and not touching during the reverse stroke of the push button (4). The completion of the contraction (like the spring) arm (29). Here, the # is used as a feed dGg, and does not need to be similar to an elastomer. However, it will be appreciated that the comparative device is not limited to the types listed above and may be of any type as designed for the device such that after the drive arm is moved toward the collapsible wall (4) of the container (1): The rotary piston (7) is limited and cannot be returned to its original position. 10014733#单号A0101 Page 12 of 40 Rotating piston (7) contains external gear teeth ((4), internal thread (25) and a flat surface at the end (26) combined with a spherical surface ((7). It is in the thread On the object, for example, a fixing bolt (8) having an external thread (3Q). The rotary piston (7) is rotated by (4) the push button (8) and its tapered tip. The rotary piston (7) utilizes its contracting arm (29), 〇越'''''''''''''''''''''''''''''''''''''''''''''''' The predetermined volume of liquid medicament to be dispensed. In a particular embodiment of the invention, the predetermined volume is about 5 microliters. It may be noted that the distance of the piston (7) is reduced. Arrangement can be done only in the finishing section of the device, and the user cannot change the volume setting to be applied. The material is avoided (4) to enable the player to play and record, thereby completely avoiding unwanted 'ie extra or less The possibility of volumetric liquid drug delivery. Therefore 'the user does not It is possible to make any kind of self-contained amount of liquid medicine (4). This continuation is one of the creative features of the device. Therefore, if the user is instructed to apply a fixed amount of drip, the best medical treatment can be achieved. Without damaging the device. The device of the present invention includes - or more locking devices to lock the rotary piston (7) 'to avoid returning from the traverse position to the first position. The locking device includes a member having a spring-like action For example, a ratchet arm (18) resembling a piece of yellow. However, it can be understood that the locking device can be of any shape and will provide a locking effect as long as the spring effect is exerted. The spring can be a resilient arm or a pole or a flat protrusion In the form of a substance, etc. The locking device maintains continuous contact with the outer gear teeth (24) of the rotary piston (7) such that when the rotary piston (7) rotates, the tooth slides over the locking device. When the external gear tooth (24) of the rotary piston (7) is locked rather than slipped, the reverse action is prevented because in the opposite direction of the rotary piston (7), the locking device It is not possible to be shrunk. While the invention has been described in terms of specific embodiments and applications, it will be apparent to those skilled in the art Spirit or color "single number 靡 1 page 13 / total 40 pages 1013146740-0 201231117 is beyond its scope. It should be emphasized that the above specific embodiments of the invention, particularly any "better" embodiment, are only The detailed description of the present invention is intended to provide a clear understanding of the principles of the present invention. The scope of the invention is limited by the following drawings. The elements in the drawings are not necessarily to scale, the In addition, in the drawings, similar component symbols indicate the corresponding parts or portions of the features from the top to the end. Cover Combination (1) · The lid assembly 1 (as shown in Figures 32, 33 and 34) consists of an outer lid Ι-a placed on top of the container lid Ι-b. It is designed in such a way that the user can easily remove the lid. The outer lid Ι-a can be mounted on the container lid b, or the two lids can be joined together in a manner known in the art, such as by heat sealing or by welding together or the like. Alternatively, use a single cover that covers the nozzle. The primary function of the lid is to protect the nozzle and the contents of the container from exposure to the external environment. Another function of the lid of the present invention is to help break the seal of the container by creating a torque by the twisting action of the lid prior to the first administration of the medicament, so that the container can be immediately used by the user for subsequent use. The shape of the outer cover 1-a (as shown in Figures 32, 33 and 34) provides an ergonomic lid handle such that the lid is twisted to create a work sufficient to break the torque of the container seal and each time It becomes easier to remove the lid before administering the medicament. Nozzle (2): The nozzle 2 is designed (as shown in Figures 14, 15 and 16) to engage the folded-box elastic portion of the collapsible wall of the container (3) (23 1001473#单单A_第14页/ A total of 40 pages 1013146740-0 201231117), rotating piston (7), push button (8) and fixing bolts (9) with a single drop of microliters of liquid. The nozzle 2 of the present invention acts to generate and dispense a droplet of a microliter size of the liquid to be dispensed. The tip end of the nozzle at its dispensing end has an inner diameter and an outer diameter ' and the tip is connected to the slit in the nozzle (2) by a capillary that tapers from the dispensing tip to the slit in the nozzle (2). The slit and the diameter of the tip of the nozzle combine to cause the formation of microliter droplets of surface tension of the liquid to be administered. The slit and the diameter of the nozzle tip can be varied to produce a fixed size microliter volume drop for liquids of different surface tensions. The nozzle (2) may be made of a hydrophobic material, or it may be coated with a hydrophobic substance to reduce the wetting of the tip, and to avoid liquid build-up to form a large drip, a container having a foldable wall (3) The container (3) of the present invention having a foldable wall (as shown in Figures 29, 30 and 31) is an integration of a stiff neck portion (37) and a bellows-shaped elastic portion (23) on the wall, the neck The portion (37) and the box-shaped elastic portion (23) on the wall are separated by a groove (13). The shape of the portion (23) may be different from the unauthorized box as long as it allows the folding of the container (3) without making the user feel that it takes a considerable amount of effort. The nozzle (2) can be mounted to the container (3), or both can be joined together in a manner known in the art, such as by interference fit or heat sealing or by welding, or can be integrated Made of or made of such an outer sleeve - left half (4) and outer sleeve - right half - outer sleeve (4) and (5) around the integrated folding box container (3), rotating piston (7) and fixing bolts ) (as shown in Figures 7, 8, 9, 1〇, n, 12, and 13) present in the device, and usually consists of a hard 10014733# single number A01〇l page 15 of 40 pages 1013146740- 0 201231117 The materials are made 'and each have a semi-elliptical groove (10) for receiving the push button (8). Each outer sleeve (4) and (5) also contains another semi-expanded circular groove (17) for mating with the level indicator (6). Grooves (14) are provided on both sides of the inference (8), which guide the push button (8) along each of the guide rails (15) provided in the outer sleeves (4) and (5). At the end of the guide rail (15), there is a stop face (16) provided in each of the outer sleeves (4) and (5). Each semicircular rib (11) having a semicircular hollowed out portion (12) is provided in the outer sleeve (4) on the groove (18) and in the wall of the (5) 'mattingly ) conforms to the groove (13) in the integrated folding box container (3). Each of the outer sleeves (4) and (5) and the groove (13) of the integrated folding container (3) are useful for precise positioning in the outer sleeves (4) and (5) And straightening the folding container (3) ' and locking the integrated folding container (3) in place to avoid the integrated folding container (3) in the outer sleeve (4) and (5) The necessary movement. 1013146740-0 The outer sleeve - right half (5) is provided with a spring-like ratchet arm (18) to limit the rotational movement of the rotary piston (7) in only one direction. This ensures that the collapsible wall of the container (3) will not expand and allow air to enter therein. A combination of each non-circular (19) (which may be a semi-hexagonal), a circular shape (20), and a rib (21) at the ends of the outer sleeves (4) and (5) securely retains the fixing bolts (9) ) in the right place. The outer sleeves (4) and (5) have been provided with an elliptical recess (22) on each of the outer surfaces to guide the user to hold the device in the correct manner. Both the outer sleeve and (5) can be secured together by methods such as snapping, twisting or the like. Provided in the outer sleeves (4) and (5) in the hollowed out part 10014733# single number A〇1〇l page 16 / total 40 pages 201231117 points (38) and (39) as a check for the container cover The window that tampering. The hollowed out portions (4〇), (41) provided in the outer sleeves (4) and (5) allow the user to continuously monitor the damage, cleanliness, etc. of the nozzle tip. Level Indicator (6): The level indicators (6) (shown in Figures 26, 27 and 28) mounted on the outer sleeves (4) and (5) are transparent components. The level indicator is a window to see the end of the validity period. At the end of the active phase, the user will see the red flag to indicate that the medicament is completely consuming light.旋转 Rotating piston (7): Rotating piston 7 (as shown in Figures 23, 24 and 25) is a combination of external gear teeth (24) and internal threads (25). The outline of the outer gear teeth (24) and the internal threads (25) are designed such that each tap of the push button (8) causes dispensing of a predetermined size. Another combination of the flat surface (26) at the end of the rotary piston (7) and the spherical surface (27) is in contact with the surface (28) of the integrated bellows container (3). The flat surface (26) axially urges the container surface (28) to squeeze the container (8) having the collapsible wall to dispense a predetermined size of drip. «The spheroidal surface (27) grips the container surface (28), thus limiting any lateral movement of the container (3). Finally, the rotary piston (7) is rotationally moved to control the upward movement of the container (3). Push button (8): The push button (8) (as shown in Figures 17, 18 and 19) is designed to rotate the rotary piston (7) when pressed. When the push button (8) is pressed, the push button (8) has a tapered tip (43) while sliding along each of the guide rails 5) provided in the outer sleeves (4) and (5). The contraction arm (μ) thus causes a rotational movement of the rotary piston (where) the tapered tip (43) conforms to the rotary piston (?) even 10014733^^^ Α〇 101 Page 17 / Total 40 Page 1013146740-0 201231117 Continue the recess between the outer gear teeth (24). When the surface (42) of the push button (8) hits each of the stop faces (16) provided in the outer covers (4) and (5), the movement of the push button (8) is restricted. Threaded objects, such as fixed thread checks (9): the parts contained in the discs (32), (33) of the fixing bolts (9) (as shown in Figures 2, 21 and 22) are firmly It is held in each of the non-circular (19) (which may be a half-hexagon), the circular (2), and the rib (21) provided on the outer sleeves (4) and (5). The external thread (3〇) of the fixing bolt (9) maintains the internal thread (25) of the rotary piston (7). When the push button (8) is released by the user, the surface (34) of the spring (31) integrated with the fixing bolt (9) pushes the push button (8) back to the β rubber ring (10): rubber ring 1〇 (As shown in Figures 35, 36 and 37) are rubber elements located at the top (35) and (36) of the outer sleeve (4) and (5), respectively. [Simple diagram] [00°5] Figure 1: Decomposed isometric view Figure 2: Complete combination front view Figure 3: Complete combination side view Figure 4: Complete combination isometric view Figure 5. Complete combination Top view Figure 6: Complete combination section view Figure 7: Outer sleeve (right half): Front view Figure 8: Outer sleeve (right half): Side view Figure 9: Outer sleeve (right half): etc. Angle View-1 Figure 10: Outer Cover (Right Half): Isometric View 1 2 Figure 11: Outer Cover (Left Half): Front View_4733#早编锐应〇1 Page 18 of 4 10 10 1013146740-0 201231117 12th picture: outer sleeve (left half): side view Figure 13: outer sleeve (left half): isometric view Figure 14: nozzle: front view Figure 15: nozzle: top view Figure 16: Nozzle: Isometric View Figure 17: Push Button: Front View Figure 18: Push Button: Side View Figure 19: Push Button: Isometric View Figure 20: Fixing Bolt: Side View Figure 21: Fixing bolts: top view Figure 22: fixing bolts: isometric view Figure 23: rotating piston: side view Figure 24 Rotating Piston: Top View Figure 25: Rotating Piston: Isometric View Figure 26: Level Indicator: Front View Figure 27: Level Indicator: Top View Figure 28: Level Indicator: Isometric View Figure 29 : Integrated Folding Container: Front View Figure 30: Integrated Folding Container: Top View Figure 31: Integrated Folding Container: Isometric View Figure 32: External Cover: Front View Figure 33: External Cover: Top View Figure 34: External Cover: Isometric View Figure 35: Rubber Ring: Front View Figure 36: Rubber Ring: Top View Figure 37: Rubber Ring: Isometric View 10014733# Single Number A0101 Page 19/Total 40 Page 1013146740 -0 201231117 [Description of main component symbols] [0006] 1-a External cover Ι-b Container cover 2 Nozzle 3 Container with foldable wall 4 External sleeve left half 5 External sleeve Right half 6 Level indicator 7 Rotate Piston 8 pusher 9 fixing bolt 10 rubber ring 11 semicircular rib 12 semicircular hollowed out part 13, 14 slot 15 guide way 16 stop surface 17 semi-elliptical groove 18 ratchet arm 19 non-circular 20 round 21 rib 22 oval recess 23 Box-shaped elastic part 24 External gear tooth 25 Internal thread 473#单号谢01 Page 20/Total 40 page 1013146740-0 201231117 2 6 Flat surface 27 Spherical surface 28 Container surface 29 Shrink arm 30 External thread 31 Spring 32, 33 Disc 34 surface 3 5 top 36 outer sleeve top 37 hard neck portion 38, 39, 40, 41 hollowed out name P minute 42 surface 43 conforms to the tapered tip of the recess between two consecutive outer gear teeth of the rotary piston
10014733#單編號 A0101 第21頁/共40頁 1013146740-010014733#单号 A0101 Page 21 of 40 1013146740-0