TW201019971A - Biological-activity containing orthopedic filler - Google Patents
Biological-activity containing orthopedic filler Download PDFInfo
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- TW201019971A TW201019971A TW97144597A TW97144597A TW201019971A TW 201019971 A TW201019971 A TW 201019971A TW 97144597 A TW97144597 A TW 97144597A TW 97144597 A TW97144597 A TW 97144597A TW 201019971 A TW201019971 A TW 201019971A
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- 230000000399 orthopedic effect Effects 0.000 title claims abstract description 23
- 239000000945 filler Substances 0.000 title abstract description 4
- 230000004071 biological effect Effects 0.000 title 1
- 239000000203 mixture Substances 0.000 claims abstract description 108
- OSGAYBCDTDRGGQ-UHFFFAOYSA-L calcium sulfate Chemical compound [Ca+2].[O-]S([O-])(=O)=O OSGAYBCDTDRGGQ-UHFFFAOYSA-L 0.000 claims abstract description 25
- 239000002639 bone cement Substances 0.000 claims abstract description 18
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 claims abstract description 14
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims abstract description 12
- 239000011575 calcium Substances 0.000 claims abstract description 12
- 229910052791 calcium Inorganic materials 0.000 claims abstract description 12
- 159000000008 strontium salts Chemical class 0.000 claims abstract 2
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 claims description 9
- 150000003839 salts Chemical class 0.000 claims description 7
- TZCXTZWJZNENPQ-UHFFFAOYSA-L barium sulfate Chemical group [Ba+2].[O-]S([O-])(=O)=O TZCXTZWJZNENPQ-UHFFFAOYSA-L 0.000 claims description 6
- ZOMBKNNSYQHRCA-UHFFFAOYSA-J calcium sulfate hemihydrate Chemical compound O.[Ca+2].[Ca+2].[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O ZOMBKNNSYQHRCA-UHFFFAOYSA-J 0.000 claims description 5
- 235000011132 calcium sulphate Nutrition 0.000 claims description 5
- 150000000703 Cerium Chemical class 0.000 claims description 4
- 210000002449 bone cell Anatomy 0.000 claims description 4
- 230000010261 cell growth Effects 0.000 claims description 4
- 230000009286 beneficial effect Effects 0.000 claims description 2
- 239000001175 calcium sulphate Substances 0.000 claims description 2
- 239000002243 precursor Substances 0.000 claims description 2
- 239000001117 sulphuric acid Substances 0.000 claims description 2
- 235000011149 sulphuric acid Nutrition 0.000 claims description 2
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 2
- 239000002253 acid Substances 0.000 claims 2
- 229940095564 anhydrous calcium sulfate Drugs 0.000 claims 2
- 239000000126 substance Substances 0.000 claims 2
- 239000011593 sulfur Substances 0.000 claims 2
- 229910052717 sulfur Inorganic materials 0.000 claims 2
- 108091071247 Beta family Proteins 0.000 claims 1
- FWKJBIILMKHXEI-UHFFFAOYSA-L P.P(=O)(O)([O-])[O-].[Ca+2] Chemical compound P.P(=O)(O)([O-])[O-].[Ca+2] FWKJBIILMKHXEI-UHFFFAOYSA-L 0.000 claims 1
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 claims 1
- 159000000009 barium salts Chemical class 0.000 claims 1
- WAKZZMMCDILMEF-UHFFFAOYSA-H barium(2+);diphosphate Chemical compound [Ba+2].[Ba+2].[Ba+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O WAKZZMMCDILMEF-UHFFFAOYSA-H 0.000 claims 1
- AYJRCSIUFZENHW-DEQYMQKBSA-L barium(2+);oxomethanediolate Chemical compound [Ba+2].[O-][14C]([O-])=O AYJRCSIUFZENHW-DEQYMQKBSA-L 0.000 claims 1
- PASHVRUKOFIRIK-UHFFFAOYSA-L calcium sulfate dihydrate Chemical compound O.O.[Ca+2].[O-]S([O-])(=O)=O PASHVRUKOFIRIK-UHFFFAOYSA-L 0.000 claims 1
- JXRVKYBCWUJJBP-UHFFFAOYSA-L calcium;hydrogen sulfate Chemical compound [Ca+2].OS([O-])(=O)=O.OS([O-])(=O)=O JXRVKYBCWUJJBP-UHFFFAOYSA-L 0.000 claims 1
- 239000012535 impurity Substances 0.000 claims 1
- FWFGVMYFCODZRD-UHFFFAOYSA-N oxidanium;hydrogen sulfate Chemical compound O.OS(O)(=O)=O FWFGVMYFCODZRD-UHFFFAOYSA-N 0.000 claims 1
- 239000011574 phosphorus Substances 0.000 claims 1
- 229910052698 phosphorus Inorganic materials 0.000 claims 1
- 239000001506 calcium phosphate Substances 0.000 abstract description 5
- 229910000389 calcium phosphate Inorganic materials 0.000 abstract description 3
- 235000011010 calcium phosphates Nutrition 0.000 abstract description 3
- 239000004615 ingredient Substances 0.000 abstract 2
- GBNXLQPMFAUCOI-UHFFFAOYSA-H tetracalcium;oxygen(2-);diphosphate Chemical compound [O-2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O GBNXLQPMFAUCOI-UHFFFAOYSA-H 0.000 description 9
- 235000019731 tricalcium phosphate Nutrition 0.000 description 9
- 239000000843 powder Substances 0.000 description 4
- 239000007787 solid Substances 0.000 description 3
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
- 230000000975 bioactive effect Effects 0.000 description 2
- 239000004568 cement Substances 0.000 description 2
- 239000002131 composite material Substances 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 239000008187 granular material Substances 0.000 description 2
- 229910003002 lithium salt Inorganic materials 0.000 description 2
- 159000000002 lithium salts Chemical class 0.000 description 2
- 150000003467 sulfuric acid derivatives Chemical class 0.000 description 2
- 229910000391 tricalcium phosphate Inorganic materials 0.000 description 2
- 229940078499 tricalcium phosphate Drugs 0.000 description 2
- 208000010392 Bone Fractures Diseases 0.000 description 1
- RWSOTUBLDIXVET-UHFFFAOYSA-N Dihydrogen sulfide Chemical class S RWSOTUBLDIXVET-UHFFFAOYSA-N 0.000 description 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
- 208000006670 Multiple fractures Diseases 0.000 description 1
- XZZZMRPZBYIFPN-UHFFFAOYSA-N O.OS(O)(=O)=O.OS(O)(=O)=O Chemical compound O.OS(O)(=O)=O.OS(O)(=O)=O XZZZMRPZBYIFPN-UHFFFAOYSA-N 0.000 description 1
- 208000001132 Osteoporosis Diseases 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 229910052788 barium Inorganic materials 0.000 description 1
- DSAJWYNOEDNPEQ-UHFFFAOYSA-N barium atom Chemical compound [Ba] DSAJWYNOEDNPEQ-UHFFFAOYSA-N 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 230000008468 bone growth Effects 0.000 description 1
- 229910000019 calcium carbonate Inorganic materials 0.000 description 1
- NEFBYIFKOOEVPA-UHFFFAOYSA-K dicalcium phosphate Chemical compound [Ca+2].[Ca+2].[O-]P([O-])([O-])=O NEFBYIFKOOEVPA-UHFFFAOYSA-K 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000010419 fine particle Substances 0.000 description 1
- -1 for example Chemical compound 0.000 description 1
- 150000002306 glutamic acid derivatives Chemical class 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 229910052588 hydroxylapatite Inorganic materials 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 239000012890 simulated body fluid Substances 0.000 description 1
- 239000002002 slurry Substances 0.000 description 1
- 229910052712 strontium Inorganic materials 0.000 description 1
- CIOAGBVUUVVLOB-UHFFFAOYSA-N strontium atom Chemical compound [Sr] CIOAGBVUUVVLOB-UHFFFAOYSA-N 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
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- Materials For Medical Uses (AREA)
Abstract
Description
201019971 六、發明說明： 【發明所屬之技術領域】 本發明替關於一種腎科填充組成物，尤指一種具有生 物活性的骨科填充組成物。 【先前技術】 傳統的骨科填充物，例如τ^27〗4^ (相當於 US-6,251，139' CN-1306865)，雖然具有促進骨細胞生長的 _ 功效，但功效相對較弱，因此在具有骨質疏鬆的患者，經 常出現填充物被吸收速率大於促進骨細胞生長速率的狀 況。 【發明内容】 本發明之一目的，在提供一種骨科填充組成物。 本發明之另一目的，在提供一種具有生物活性的骨科 _ 填充組成物。 本發明之又一目的，在提供一種含微溶性銘鹽的骨科 填充組成物。 本發明之再一目的，在提供一種含微溶性鋰鹽的生物 活性骨科填充組成物。 本發明之另一目的，在提供一種含微溶性勰鹽和含鈣 骨水泥成分的骨科填充組成物。 本發明之又一目的’在提供一種含微溶性锶鹽和含鈣 骨水泥成分的生物活性骨科填充組成物。 201019971 本發明為一種骨科填充組成物，其包含： 含鈣的骨水泥成分，其係為硫酸鈣鹽、磷酸鈣鹽、及/ 或其混合物、組成物或加成物；及 微溶性勰鹽，其含量為該含鈣骨水泥成分的〇」wt%至 5wt% 〇 上述硫酸鈣鹽，其可為任意硫酸鈣鹽，例如為無水硫 酸妈（calcium sulfate anhydrate)、半水硫酸 1弓（calcium sulfate hemihydrate)、二水硫酸好（calcium sulfate dihydrate)、無水硫酸約/半水硫酸約的混合物（mixture)，組 成物（composition)或加成物（adduct)、無水硫酸飼/二水硫酸 鈣的混合物，組成物或加成物、半水硫酸鈣/二水硫酸鈣的 混合物，組成物或加成物、或無水硫酸#5 /半水硫酸#5 /二水 硫酸鈣的混合物，組成物或加成物。 上述所謂磷酸鈣鹽，係指磷酸二鈣（DCP，di-calcium phosphate)、·罐酸三約（TCP，tri-calcium phosphate)、鱗酸 四 #5 (TTCP，tetra-calcium phosphate)、氫氧基麟灰石（HA， hydroxy-apatite)、其先驅物（precusor)、DCP/TCP 的混合 物、組成物或加成物、DCP/TTCP的混合物、組成物或加 成物、DCP/HA的混合物、組成物或加成物、TCP/TTCP的 混合物、組成物或加成物、TCP/HA的混合物、組成物或加 成物、TTCP/HA 的混合物、組成物或加成物、 DCP/TCP/TTCP的混合物、組成物或加成物、DCP/TCP/HA 的混合物、組成物或加成物、DCP/TTCP/HA的混合物、組 成物或加成ίϊ、TCP/TTCP/HA的混合物、組成物或加成物、 201019971 * , DCP/TCP/TTCP/ΗΑ的混合物、組成物或加成物。 上述所謂硫酸鈣鹽和磷酸鈣鹽的混合物、組成物或加 成物’係指以硫酸範鹽為主要成分（大於5 〇wt%)的混合物、 組成物或加成物、以磷酸鈣鹽為主要成分（大於5〇wt%)的 混合物、組成物或加成物、或以硫酸鈣鹽和磷酸鈣鹽為主 要成分（兩者總重大於50wt%)的混合物、組成物或加成物。 上述所謂含鈣的骨水泥成分，係指使用前係成粉狀或 顆粒狀，經加水或水溶液後形成漿料，最後熟化成一體（實 質上為固體）’。其能形成骨水泥成分，可為半水硫酸鈣骨水 泥成分，參見TW-I227146 (相當於us_6 251 139、 CN-1306865)、或為磷酸鈣鹽骨水泥成分，參見諸如 US-6,703,038、或半水硫酸鈣骨水泥成分和磷酸鈣鹽骨水泥 成分的混合物、組成物或加成物、當然也可以是表面為上 述含鈣的骨水泥成分（内層不必然為相同成分）的複合成 分，例如磷酸鈣鹽或碳酸鈣外層覆以含鈣的骨水泥成分。 G 上述微;谷性錯鹽’其可為硫酸銷、碳酸錄'構酸錄鹽、 或任意習知有利於骨細胞生長功能的鰓鹽，例如雷奈酸鳃 (strontium rdlnelate)。 上述該微溶性鋰鹽含量為該含鈣骨水泥成分的 〜5wt%’以0.2〜4wt%為較佳，以〇 5〜2wt%為更佳。 上述骨科填充組成物，其可為任意型式的骨科填充組 成物，例如粉末狀、顆粒狀、複合物料型式等。以粉末狀 或細顆粒狀為較佳，以粉末狀為更佳。 上述骨科填充組成物，其可配合碎骨（b〇ne gra⑴使 201019971 用’亦可額外加入藥品及/或營養劑等物料，一 (例如US-fi β知技術 U如US 6,2Μ，139)所述。上述骨科填充組成物，亦可額外 其他物知，例如加入顯影劑（例如硫酸鋇）、血清、血 漿或全血（參見TW-504376)。 上述硫酸鈣和鳃/鈣磷酸鹽，雖然具有顯影效果，但以 進一步加入顯影劑，例如硫酸鋇為較佳。 罄 【實施方式】 本發明的骨科填充組成物，在模擬體液中，可促進磷 酸鈣鹽的形成，亦即具有具有生物活性，可促進骨細胞生 長201019971 VI. Description of the Invention: TECHNICAL FIELD OF THE INVENTION The present invention relates to a renal filling composition, and more particularly to a biologically active orthopedic filling composition. [Prior Art] Traditional orthopedic fillers, such as τ^27〗 4^ (equivalent to US-6,251,139' CN-1306865), although having the effect of promoting bone cell growth, are relatively weak in efficacy and therefore have In patients with osteoporosis, it is often the case that the rate of absorption of the filler is greater than the rate at which bone growth is promoted. SUMMARY OF THE INVENTION One object of the present invention is to provide an orthopedic filling composition. Another object of the present invention is to provide a biologically active orthopedic filling composition. Another object of the present invention is to provide an orthopedic filling composition containing a sparingly soluble salt. Still another object of the present invention is to provide a bioactive orthopedic filling composition containing a sparingly soluble lithium salt. Another object of the present invention is to provide an orthopedic filling composition containing a sparingly soluble cerium salt and a calcium-containing bone cement component. A further object of the present invention is to provide a bioactive orthopedic filling composition comprising a sparingly soluble onium salt and a calcium-containing bone cement component. 201019971 The present invention is an orthopedic filling composition comprising: a calcium-containing bone cement component which is a calcium sulfate salt, a calcium phosphate salt, and/or a mixture, a composition or an adduct thereof; and a sparingly soluble cerium salt, The content is the wt% to 5 wt% of the calcium-containing bone cement component, and the calcium sulfate salt may be any calcium sulfate salt, for example, calcium sulfate anhydrate, calcium sulfate. Hemihydrate), calcium sulfate dihydrate, anhydrous sulfuric acid/hemihydrate sulfuric acid mixture, composition or adduct, anhydrous sulfuric acid/calcium sulfate dihydrate mixture , a composition or an adduct, a mixture of calcium sulfate hemihydrate/calcium sulfate dihydrate, a composition or an adduct, or a mixture of anhydrous sulfuric acid #5 / hemihydrate sulfuric acid #5 / calcium sulfate dihydrate, composition or addition Adult. The above-mentioned so-called calcium phosphate salt refers to di-calcium phosphate (DCP), tri-calcium phosphate (TC), tetra-calcium phosphate (TTCP), hydrogen and oxygen. HA, hydroxy-apatite, its precursor, mixture of DCP/TCP, composition or adduct, mixture of DCP/TTCP, composition or adduct, mixture of DCP/HA , composition or adduct, TCP/TTCP mixture, composition or adduct, TCP/HA mixture, composition or adduct, TTCP/HA mixture, composition or adduct, DCP/TCP /TTCP mixture, composition or adduct, DCP/TCP/HA mixture, composition or adduct, DCP/TTCP/HA mixture, composition or addition, TCP/TTCP/HA mixture, Composition or adduct, 201019971*, DCP/TCP/TTCP/ΗΑ mixture, composition or adduct. The above-mentioned mixture, composition or adduct of the calcium sulphate salt and the calcium phosphate salt refers to a mixture, a composition or an adduct containing a sulfate salt as a main component (greater than 5 〇 wt%), and a calcium phosphate salt. A mixture, composition or adduct of a main component (greater than 5 wt%), or a mixture, a composition or an adduct containing a calcium sulfate salt and a calcium phosphate salt as main components (both of which are mainly greater than 50% by weight). The above-mentioned calcium-containing bone cement component is a powder or granule which is formed into a powder or granule before use, and is formed into a slurry by adding water or an aqueous solution, and finally matured into a solid (solid solid). It can form a bone cement component, which can be a calcium sulfate hemihydrate bone cement component, see TW-I227146 (equivalent to us_6 251 139, CN-1306865), or a calcium phosphate salt bone cement component, see for example US-6,703,038, or half A mixture, a composition or an adduct of a calcium sulphate cement component and a calcium phosphate cement component may, of course, be a composite component having a surface of the calcium-containing bone cement component (the inner layer is not necessarily the same component), such as phosphoric acid. The calcium or calcium carbonate outer layer is coated with a calcium-containing bone cement component. G. The above-mentioned micro; glutamate salt </ RTI> may be a sulphuric acid pin, a sulphate salt, or any sulfonium salt which is known to be beneficial for bone cell growth, such as strontium rdlnelate. The content of the sparingly soluble lithium salt is preferably from 5% to 5% by weight of the calcium-containing bone cement component, more preferably from 0.2 to 4% by weight, more preferably from 5% to 2% by weight. The orthopedic filling composition may be any type of orthopedic filling composition such as a powdery form, a granular form, a composite material type or the like. It is preferably in the form of a powder or fine particles, and more preferably in the form of a powder. The orthopedic filling composition can be used in combination with broken bones (b〇ne gra (1) for 201019971 can also be added with additional drugs and/or nutrients, etc., for example (for example, US-fi β knowing technology U such as US 6,2Μ,139 The above orthopedic filling composition may also be additionally known, for example, by adding a developer (for example, barium sulfate), serum, plasma or whole blood (see TW-504376). The above calcium sulfate and barium/calcium phosphate, Although it has a developing effect, it is preferable to further add a developer such as barium sulfate. [Embodiment] The orthopedic filling composition of the present invention can promote the formation of a calcium phosphate salt in a simulated body fluid, that is, has a living body. Active, can promote bone cell growth
Claims (1)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| TW97144597A TW201019971A (en) | 2008-11-18 | 2008-11-18 | Biological-activity containing orthopedic filler |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| TW97144597A TW201019971A (en) | 2008-11-18 | 2008-11-18 | Biological-activity containing orthopedic filler |
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| Publication Number | Publication Date |
|---|---|
| TW201019971A true TW201019971A (en) | 2010-06-01 |
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|---|---|---|---|
| TW97144597A TW201019971A (en) | 2008-11-18 | 2008-11-18 | Biological-activity containing orthopedic filler |
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| Country | Link |
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| TW (1) | TW201019971A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI453174B (en) * | 2010-10-19 | 2014-09-21 | Univ Nat Cheng Kung | Bone cement formula and bioresorbable hardened bone cement composites prepared with the same |
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2008
- 2008-11-18 TW TW97144597A patent/TW201019971A/en unknown
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI453174B (en) * | 2010-10-19 | 2014-09-21 | Univ Nat Cheng Kung | Bone cement formula and bioresorbable hardened bone cement composites prepared with the same |
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