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TW200906370A - Sensing device applied in photodynamic therapy and diagnosis - Google Patents

Sensing device applied in photodynamic therapy and diagnosis Download PDF

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Publication number
TW200906370A
TW200906370A TW96128310A TW96128310A TW200906370A TW 200906370 A TW200906370 A TW 200906370A TW 96128310 A TW96128310 A TW 96128310A TW 96128310 A TW96128310 A TW 96128310A TW 200906370 A TW200906370 A TW 200906370A
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Taiwan
Prior art keywords
light
treatment
signal
circuit
diagnosis
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TW96128310A
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Chinese (zh)
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TWI328444B (en
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Shyh-Liang Lou
Tzong-Rong Ger
Yih-Chih Hsu
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Shyh-Liang Lou
Tzong-Rong Ger
Yih-Chih Hsu
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Priority to TW96128310A priority Critical patent/TW200906370A/en
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Publication of TWI328444B publication Critical patent/TWI328444B/zh

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Abstract

A sensing device applied in photodynamic therapy (PDT) and diagnosis is disclosed, which is applied in the creature to excite the photosensitive agents in the body to generate the photochemical reaction. The sensing device comprises an emitter and a light source installed inside body. The emitter can emit a wireless signal penetrating through the surface layer of a creature. After receiving the wireless signal, the light source emits the light, which has the wavelength to match with the photosensitive agent, to make the agent generate the photochemical reaction.

Description

200906370 九、發明t兑明: [發明所屬之技術領域】 本ϋ係有關於—種感應裝置 動力診斷與治療之感應裝置。 種應用"- 【先前技術】 隨著醫療科技及技術的快速發展,光 therapv,PDT、日 “ ^^(photodynamic 偉觀破傳統癌棘治財_歧技術。配合 物雜咖轉物繼的癌腫瘤 由沪光細胞加㈣滅,iX翻最佳的治療效果。 虫方、忐動力療法具有對串體 的失調、—人u 4小、避免患者免疫功能 不傷宝後恢復迅速、可選擇性殺舰瘤細胞.而 —。,已a為近年來備受目的醫療技術之 段日士 it療法係先對患者注射或是塗抹光敏感_,並給予一 敏感藥劑附著於腫瘤細胞上,再藉由光照射娜出 線,以激發光敏感藥劑產生—光活化反應,引發 L田胞W生,進而消ί烕腫瘤細胞。 足,絲力療法受限於抽力照贱置之光源穿透力不 此夕半用於人體表層器官的治療上, 等病症’照射裝置係直接照射於人體 ::二:空癌 的治療效果。 乂達到涓滅腫瘤細胞 近年來,光動力療法亦開始應用於人體較為深層 揭腫瘤治療為例,患者在進行外科手術的同時,會將生物 200906370 相容材料一併植入顱腔内,並導八一光纖至生物相容#料内,以 對顱腔π殘留的腫瘤細胞進行光照射治療,克服了傳統光動力裝 置無法針對顱内腫瘤進行治療的限制。 但對於患者而言,藉由外露於頭部的光纖進行顱内組織的光 照射,係屬於侵入式的治療方式,長期的治療過程,對於患者的 生理或是心理上都是極大的負擔,不僅對患者的平日生活造成相 當多的不便外,更存在有顱腔容易遭受細菌感染的危險性。 為了減少患者於長時間治療的不便及所產生的副作用,習用 光動力照射裝置之光源多半會採用高光功率之發光元件,如雷射 等高能量的發光體,而大幅縮短光照射療程所需的時間,以減缓 患者的不適感與細菌感染的風險。 然而,於近年發表的相關研究報告顯示,以高光功率、短時 間之光動力治療方式,所得到的療效並不如以低光功率持續照射 患部的治療效果。就目前的光動力治療技術而言,是無法兼具患 者於治療過程中的安全性及舒適性,並且同時獲得較佳的治療成 效。 【發明内容】 鑒於以上的問題,本發明提供一種應用於光動力診斷與治療 之感應裝置,藉以改良先前技術之光動力照射裝置無法進行人體 體内的疾病診斷,且習用光動力照射裝置必須裝設一露出於人體 外之光纖導線,造成患者於治療期間内的不適與不便,以及習用 光動力治療無法同時兼具患者身心的負擔,與獲得較佳治療成效 的限制。 200906370 應線圈之控制電路、及 —· ^* 、当 本發明所麟之麵於光動力辑與練喊缝置,係使 用於生物的祕上,以數發注射於生物體内之光敏缝财土光 化學錢。感應裝置包括有—發射器,及—可被植入生物體_ 光照射$ ’光照射n具有m制、—電性連接於第一感 接於控制電路之發光元件。 發射器用以m穿透生物表f之無線訊號,光照射器之第 -感應線隨⑶線訊魏,藉由控制電路將無線訊號轉換為— 驅動訊號’令奸τΜ+m波長匹配於級感_之光線,以 使光敏感藥劑產生光化學反應。 本發明之功效在於M立於生物體外之發射器藉由無線能量傳 輸方式,以電韻應設置於生物體内之光照射器發出—光線了而 激發光魏㈣m應,以進行生物體的診斷或是治療。本發 明不僅改善了以有線傳輪方式進行治療之制光動力治療裝置, 於治療期簡生物體所產生的各制侧、不親、以及平日生 活不便的問題’更同日I具備生物體之健康安全性與較佳治療效果 的功效。 以上之關於本發㈣容之說明及以下之實絲式之說明係用 以示範與糖本發明之原理,並且提供本發明之專辦請範圍 進一步之解釋。 【實施方式】 根據本發賴揭露翻於絲力麟與治療之感應裝置,係 藉由無線傳輸能量之方錢行作動,而此無線傳輸能量方式包括 但不侷限於無線射頻(radio frequency ,即)、或是微波傳輪等無綍 200906370 傳輸技術。以下本發明的詳細說日月中,將以使用IKdHZ主右之I 線射頻傳輸(RH做為本發明之最佐實施例。然而所蚜_式僅提供 參考與說明用’並非用以限制本發明° ’ 如「第1A圖」及「第1B圖」所示,本發明所揭瘵應兩於光 動力診斷與治療之感應裝置100,係使用於一生物200上,用以 激發注射於生物200體内之光敏感藥劑(圖中未示)產本光化學反 應,而對生物200之細胞組織進行治療,例如惡性腫瘤、黑斑、 皮膚美白、傷疤、眼底黃斑部病變' 或是顯影標示特定細胞組織 等用以針對不良細胞之治療方式。 值得注意的是’本發明於實施例中所述之感應裝置,係以治 療人體内之腫瘤細胞做為實施例的說明,熟悉該項技術者,可根 據貫際的使用需求,而應用於各類生物種的診斷與治療上,並不 以本發明之實施例為限。 本發明之感應裝置包括有一發射器H0及一光照射器i2〇(見 第1B圖」)。發射器11〇具有一第二感應線圈1124,用以發出 —愿線射娜號,且此無線射頻城可穿透過生物之表層, =如人體的皮膚、脂肪、她肉縣層組織,而傳遞至生 體内。 ⑵二置於生物200體内之光照射器12〇具有一第—感應軸 控制Μ —細 號係用以接收發射器⑽射出之無線射頻言 曰上刎甩路122將無線射頻訊號轉換為一具有電壓之馬 200906370 動訊號’以產生一電流°發光元件12j cj马一發光二極體成户" 射發射器等先源產生裝置,發光元件123於接收驅動訊號辧虞务 之電流後,發出一匹配於光敏感藥劑之特定波長的光線,以漱够 光敏感藥劑產生光化學反應。 •a 本發明係以一 5-ALA( 5-aminolevulinic acid) ^ hematoprophine類之光敏感藥劑,例如為Photofrin做為實施例 之說明,熟悉光動力治療之該項技術者,可根據實際的使用需 求’而對應使用不同的光敏感藥劑,並搭配與光敏感藥劑相氐私 之光線進行活化激發,並不以本發明之實施例為限。5-ALA及 Photofrin等藥劑的較佳活化波長約為630nm,並搭配發光元件 123所發出之紅色光源,以激發5-ALA及Photofrin藥劑產生光 化學反應,進而治療生物200體内之腦癌、食道癌、胃腸道癌、 膀胱癌、或是肺癌等腫瘤細胞。由於5-ALA光敏感藥劑具備有 毒性低、代謝快、及避光時間只需1至2天等優點,而開始廣泛 應用於醫療臨床的治療上。 光敏感樂劑需要接收—定強度的能量才可被激發反應,因此 本發明可藉由控制發光元件123之光功率大小,或是光照射時間 等茶數’而可精確掌握治療過程的療時,並且避免生物2⑻因光 功率過強所產生的不適感及副作用。 5月麥閱「第2圖」之發射器的電路方塊圖。如圖所示,本發 明之發射g 110包含有―驅動電路ln及—震盪電路112。驅動電 路111中具有-波形產生器lm、—電性連接於波形產生器仙 之k頻1112、-電性連接於除頻器η〗]之反向器mg、二電 10 200906370 性連接於反向器ms之謂變器]m、二分別電性連接於娜吳 im之d類功率放大器⑴5、及二分別技連結於d類功^ 大器1115之變壓器]1]6。 ' 其中,波形產生器1U!係用以產生—方波,此方波透過除頻 器1112調整至-特定藏圍之載波頻率,再藉由反向器⑴3牌, 整後之方波傳遞至二調變器丨„4中,以分別產生二反向之具有^ 定波寬與振幅的方波訊號。方波訊號經由功率放大器5益作 用·而傳遞至變壓器1]16内,並藉由二變壓器1116的轉換,使 得正波訊號分別以-正弦波與一負弦波型態之控制訊號輸出。、 發射器1]0之震里電路112包括有一電源⑽、二雷^部 料源⑽之電晶體卿„22、以及—紐連接於電晶 之共振電路ms,共振電路1123具有—電性連接於電晶體 開關之第二感應線圈1124,及一電性連接於第二感 1124之電容1125。 f巾,⑨阳收開關1122係用以分別接收變壓器1116之控 作目反於另—電晶體開關1122執行開啟或是關閉的動 :源⑽根據其中一呈開啟狀態之電晶體開關⑽,而持續 峥通-电流至共振電路1123中,第二残 ^ , 及愿綠圈1124錯由電容1125 而开《用,以產生並發出—無線訊號至第-感應線圈121, 而形成一磁力場感應耦合。 ϋ用參閱「第3Α F1 这「& on 電路方塊圖。光昭射=之=圖」之光照射器立體示意圖與 及-電性、皇垃…、 制電路122具有一整流器1221, 接於整流器1221與發光元件⑵之穩壓器1222。控 1] 200906370 制電路122將第一感應線圈 電性之驅動訊號,驅動訊號透過驽、、 1接收〜礤丨生之無線訊號轉換為 1的作用,以將原本 1222 因驅動訊號的電壓 雙向震盪之驅動訊號轉換為單向震盪的却扶、, 卜 〕αΚ唬,亚藉由穩壓 維持一定的輸出值範圍,以避免發光元件Ρ 值不穩定而造成損壞。本發明揭露之整流器1221可為半波整添 器、全波整流[或是橋式整流器之任―縣的整㈣,然此— 技術已為滅綱技術之通常人切能知㈣輯,故發明人於 此不另贅敘。 ' 請繼續參閱「第3Α圖」,光照射器]20外圍更具有一透明可 透光之包覆材料15G,以完全包覆住第—感應線圈ι2ι、控制電路 122、及發光tl件123。包赌料15Q係以生物㈣賴料或是玻 璃_所製成,不但具有良好的生物相容性,更具備優良的絕緣 與散熱效果’避免設置於生物2⑻體内之光照射器12Q,因運作 所產生的過高熱能造成生物200的不適感。 由於光照射器120具備優良的生物相容性,因此可選擇於療 程結束後,將光照射器120自生物200體内取出;或是長期置= 於生物2⑻體内,以免除再次進行外科手術的不便,以及必須承 擔的風險性。 如「第1B圖」所示,本發明更包含有一銜接於發光元件η] 之散射元件130,放置於生物200體内之散射元件130具備有良 好的生物相容性’不致引起生物200的免疫排斥反應。本發明之 散射元件130係為—内部具有容置空間之球體材料,且於散射元 件130内部填裝有—流體14〇,例如為空氣、生理食鹽水、戋是 12 200906370 油水混合鱗咖性之綠⑽,其幅姐絲可選用力保 肪寧ilipoflmdiii)或是因转古α —酿神叹為練㈣之流體 本^之「第4圖」細油水齡物·力保肪寧伽涵㈣ 做為本貫施例之說明,菸本_ ▲ #, 先凡仵12j發出之不同功率大小的光 声:'之流體140(以。.12%之u_-為例) ===向外散射’其光線之穿透舰率係隨著光功率的提 =線=!:。操作者可_實_心適當的光功 率大~、,U均勻照射喹你0 效果良好的光動力治療致果。I⑽减細胞’而達到高效率且 内同時比較將槪件123置於散射元㈣ ㈤卞12項接於散射元件13〇表面之散射穿透率 醜得知,發締123置於散射請戰之 遠低於發光元件123銜接於散射元請表面之散 此,本發明係以發光元们23銜接於散射元件D 之型態作騎佳實施例之朗。 放射讀1:0表田 作動確認設置觸2G峨之光職胸實地 亦可於乂 圖」及$JB®」所示,本發明在進行治療時, ⑵之^元件123内安裝有光感測器⑺,用以積測發光元件 強产之^所折射回來的光線,以推算發光元件123所發出之光 元170係電輯接於控制電路122,以制由發光 電路12之姐強度,並將此光功率之類比訊號傳送至控制 私 ’以進行訊號的數位解調’再以無線射頻(RF)或是微 200906370 波寺無線傳輪方式傳送至外部的解調器(圖中未示).從而得知目前 的發光強度,以輔助醫療者換算病患所需照射的時間。 或是於接近光照射器120之生物2⑻體外設置一光感測器(圖 ,未示)乂接彳^先知、务」為120以無線訊號回饋其目前的作動狀 態’例如回饋其發光元件123是否發出光線、及此光線的光功率 大小寸情況,使醫療者得以暸解生物2⑻體内的治療情況。 如第1B圖」及「第5圖」所示,為了觀察内部的治療狀況, 更可於生物2⑻體内裝設-取像裝置18G。其中,取像裝置18〇 具=-處理器⑻,及電性連接於處理器181之第三感應線圈 ⑻、取像器183、與無線_發射器184。第三感應線圈脱於 倾第二感應_ 1124所發出之無線訊號制始作動,當光照射 1J)恥射生物2〇〇的過程中,取像器183將生物2⑻籍由光線 叩產生之光強度,遷過處理器⑻轉換為—輸出訊號,並經由無 線訊號發射器184,以無線射頻_或是微波等無線傳輸方式傳送 至卜σ「的接收益(圖中未示),從而得知目前的内部治療狀況。 ι =外,為了快速處理取像裝置18〇所產生的輸出訊號,更可 光’、射120内加設二天線(圖中未示),以分別接收及傳輸輪 出訊號,使得以圖像訊號為主之輸出訊號,得以快速地傳遞至外 部的接收器。 像裝置18G亦可結合於光照射器12Q内,無需使用第三感 =圈182 ’藉由共用控制電路122所產生之電流,以驅動取像 為⑻^動’使得設置於生物體内之裝置可更為精簡。 士第圖」所示,本發明之光照射器12〇更包括有一二次 14 200906370 電池190,係電性連接控制電路122及發光元技 一 ,—,且二次雪沖 190具有一充放電迴路191。當控制電路1二之 一 w η,,κ κ 劫訊·破經由整流 為1 — 1 ,入德壓為1222的轉換’以對二次雪池3% - 進4亍充雷,再 透過外部無線觸發的方式,啟動二次電池190執行气θ浐二如ν 電能至發光元件123,光照射器120無須隨時與外部 ",'、 中未不對準,使用者的行動將不受限制,而可 也進行治療。 -中,啟動或是停止二次電池卿之電力輸出,謂由不同瓣 的病合《、微處理器的內部程式碼、或㈣_波訊號技術解 调外部訊號等驅動方式,以對二次電池19〇進行控制。 「第6A圖」至「第6E圖」為本發明之感應裝置應用於治療 及診斷生物各部位之器官組織的示賴。本發明揭露之一p 1〇〇可應用於治療人體200(生物體)各個部位,例如顧月空 胸腔、腹腔、骨盆腔内之各器官組織_瘤治療。本發明之發:射 器110可籍由一綁持或是佩帶於人體上的保持件⑽而固I 設置於相對人11200體内之級射器⑽的位置,以使發射哭= 得以與光照射㈣0之_過無__輪的方式進行治療。。 保持件⑽上具有一容設部161,以供發射器110固設於立 中。且保持件副可配合人體測欲治療的部位,而設計為- :罩、或是束帶等各種型態,以方便佩帶綁持於人體對 光照射器120之位置。 Ί 阶與===轉齡卜物峨祕線訊號的 ^ 置於生物體内之光照射器相互電磁感應,光照射哭 错由磁讀換效應,何發出特定波長的光線,以激發匹配之^ 200906370 敏感藥劑產生光化學反應,以進行生物燧的診斷或是治療。才 明改善了習用元助力’口療s呈·線傳輪方式的不便,並降倍夕 體遭受細菌感染的危險性。 v 本發明之發㈣更藉由保持_設置,使料'者料療過程 中的行動將不受發射器的限制,並可精確控制光照射哭p〇 “ 功率或是光照射時間,以減緩人體因治療時所產生不適感.並同 時獲得較佳治療效果之功效。 雖然本發明之實施例揭露如上所述,然並非用以限定本發 明,任何熟習相關技藝者,在不脫離本發明之精神和範圍内,舉 凡依本發明情額所述之、構造、特徵及料當可做些: 之變更,·本發明之專利保護範ϋ魏本說明# 利範圍所界定者為準。 【圖式簡單說明】 第1Α圖為本發明感應裝置之平面示意圖; 第1Β圖為本發明之感應裝置應用於人體上之侧視圖 第2圖為本發明發射益之電路方塊圖; 第3Α圖為本發明光照射器之立體示音圖. 第3Β圖為本發明光照射器之電路方塊圖. 第3C圖為本發明具有二次電池之光照射器之電路方塊圖·, 第4圖為本發明之抑切率之級經由脑元件之流體所產生 之穿透散射率之量測圖; 苐5圖為本發明取像裝置之電路方塊圖. 第6Α圖為本發明之感應袭置應用於人體顧腔址織之診斷及治療 16 200906370 之側視圖, 第6B圖為本發明之感應装置應用於人體口腔組織之診斷及治療 之側視圖, 第6C圖為本發明之感應裝置應用於人體胸腔器官之診斷及治療 之側視圖; 第6D圖為本發明之感應裝置應用於人體腹腔器官之診斷及治療 之侧視圖;以及 第6E圖為本發明之感應裝置應用於人體骨盆腔器官之診斷及治 療之側視圖。 【主要元件符號說明】 100 感應裝置 110 發射器 111 驅動電路 1111 波形產生器 1112 除頻器 1113 反向器 1114 調變器 1115 功率放大器 1116 變壓器 112 震盪電路 1121 電源 1122 電晶體開關 1123 共振電路 17 200906370 1124 第二鼠應線圈 1125 電容 120 光照射器 121 第一感應線圈 122 控制電路 1221 整流器 1222 穩1器 發光元许 散射元件 140 流體 150 包覆材料 160 保捋件 161 容設部 170 光感測器 180 取像裝置 181 處理器 182 第三感應線圈 183 取像器 184. 無線訊號發射器 190 二次電池 191 充放電迴路 200 生物 18200906370 IX. Inventions and inventions: [Technical field to which the invention belongs] This is a sensing device for dynamic diagnosis and treatment of a sensing device. Applications "- [Previous technology] With the rapid development of medical technology and technology, light therapv, PDT, and the day "^^(photodynamic weiguan breaks the traditional cancer and cures the problem. Cancer tumors are replaced by Huguang cells plus (4), and iX is the best therapeutic effect. Insect and sputum dynamic therapy has a disorder of the body, and the human u 4 is small, avoiding the patient's immune function and recovering quickly, and can choose Sex killing of tumor cells. And, has been a recent medical technology in the segment of the Japanese medical treatment system is first sensitive to the patient injection or smear _, and a sensitive agent attached to the tumor cells, and then By illuminating the light out of the line, the photo-sensing agent is stimulated to generate a photo-activated reaction, which triggers the L-field cell growth, thereby eliminating the tumor cells. Foot, silk force therapy is limited by the light source penetration of the pumping device The force is not used for the treatment of human superficial organs, etc., and the disease 'irradiation device is directly irradiated to the human body: 2: The therapeutic effect of empty cancer. 乂Achieving annihilation of tumor cells In recent years, photodynamic therapy has also begun to be applied. Deeper human body For example, in the treatment of tumors, the patient will implant the bio-200906370 compatible material into the cranial cavity and guide the fiber into the biocompatible material to light the tumor cells of the cranial cavity. Irradiation treatment overcomes the limitation that traditional photodynamic devices cannot treat intracranial tumors. However, for patients, light exposure of intracranial tissue by optical fibers exposed to the head is an invasive treatment. The treatment process is a great burden on the patient's physical or psychological, not only causes considerable inconvenience to the patient's normal life, but also has the risk that the cranial cavity is susceptible to bacterial infection. The inconvenience and the side effects caused by the conventional light-powered illumination device will mostly use high-light power illuminating elements, such as high-energy illuminators such as lasers, and greatly shorten the time required for the light irradiation treatment to slow down the patient's Discomfort and the risk of bacterial infection. However, relevant research reports published in recent years show that with high optical power, The light-dynamic treatment of time, the effect obtained is not as good as the continuous treatment of the affected part with low light power. In the current photodynamic therapy technology, it is impossible to combine the safety and comfort of the patient in the treatment process. At the same time, better therapeutic results are obtained. SUMMARY OF THE INVENTION In view of the above problems, the present invention provides an inductive device for photodynamic diagnosis and treatment, whereby the photodynamic illumination device of the prior art can not be used for disease diagnosis in the human body. And the conventional photodynamic illumination device must be equipped with an optical fiber lead exposed outside the human body, causing discomfort and inconvenience to the patient during the treatment period, and the conventional photodynamic therapy cannot simultaneously have the physical and mental burden of the patient, and obtain better therapeutic effect. 200906370 The control circuit of the coil, and -· ^*, when the surface of the invention is used in the photodynamic series and the practice of shouting, is used in the secret of the creature, and is injected into the living body with several hairs. Photosensitive sewing money photochemical money. The sensing device includes a transmitter, and - can be implanted into the body _ light illuminating the light illuminating element n having an electrical system connected to the first illuminating element that is coupled to the control circuit. The transmitter is used to penetrate the wireless signal of the biological watch f, and the first-inductive line of the light illuminator is connected with the (3) line, and the wireless signal is converted into a driving signal by the control circuit to match the level of the τΜ+m wavelength. The light of _ to cause a photochemical reaction of the light sensitive agent. The effect of the invention is that the emitter of the M-external body is transmitted by the wireless energy transmission method, and the light illuminator which should be set in the living body emits light, and the light is excited to perform the diagnosis of the organism. Or treatment. The invention not only improves the photodynamic therapy device which is treated by the wire-passing method, but also has the problems of the side, the involuntary, and the inconvenience of the daily life caused by the simple organism in the treatment period. Safety and efficacy of better treatment. The above description of the present invention (four) and the following solid-state description are used to demonstrate the principles of the invention and to provide further explanation of the scope of the invention. [Embodiment] According to the present disclosure, the sensing device that is turned over to the silk force and the treatment is operated by wirelessly transmitting energy, and the wireless transmission energy mode includes but is not limited to a radio frequency ( ), or wireless transmission wheel and other innocent 200906370 transmission technology. In the following detailed description of the present invention, the I-line radio transmission using the IKdHZ main right will be used (RH is the most preferred embodiment of the present invention. However, the formula is only for reference and explanation. Invention As shown in FIG. 1A and FIG. 1B, the present invention discloses a sensor device 100 for photodynamic diagnosis and treatment, which is used on a living body 200 to stimulate injection into a living being. The light-sensitive agent in the body (not shown) produces a photochemical reaction, and treats the cell tissue of the organism 200, such as malignant tumor, dark spot, skin whitening, scar, macular degeneration of the fundus or development mark The specific cell tissue or the like is used for the treatment of the defective cells. It is noted that the sensing device described in the embodiments of the present invention is for the treatment of tumor cells in the human body as an example, and those skilled in the art are familiar with the technology. It can be applied to the diagnosis and treatment of various biological species according to the requirements of the continuous use, and is not limited to the embodiment of the present invention. The sensing device of the present invention comprises a transmitter H0 and a light illuminator. I2〇 (see Figure 1B). The transmitter 11〇 has a second induction coil 1124 for emitting a line of light, and the wireless RF city can penetrate the surface of the living body, such as the skin of the human body. The fat, her meat county layer tissue, and passed to the living body. (2) The second light illuminator 12 置于 placed in the body of the living body has a first-induction axis control Μ - the fine number is used to receive the wireless emitted by the transmitter (10) The radio frequency circuit 122 converts the radio frequency signal into a voltage with the horse 200906370 motion signal 'to generate a current. The light-emitting element 12j cj horse-light-emitting diode-to-home " launcher and other precursor generating device After receiving the current of the driving signal, the light-emitting element 123 emits light corresponding to a specific wavelength of the light-sensitive agent to generate a photochemical reaction for the light-sensitive agent. • The present invention is a 5-ALA ( 5-aminolevulinic acid) ^ Hematoprophine type light-sensitive agent, for example, Photofrin as an example of the description, the person familiar with photodynamic therapy, can use different light-sensitive according to the actual use requirements The activation of the agent and the light illuminating with the light-sensitive agent is not limited to the embodiment of the present invention. The preferred activation wavelength of the agent such as 5-ALA and Photofrin is about 630 nm, and is matched with the light-emitting element 123. A red light source is emitted to stimulate the photochemical reaction of 5-ALA and Photofrin agents to treat tumor cells such as brain cancer, esophageal cancer, gastrointestinal cancer, bladder cancer, or lung cancer in vivo 200. Due to 5-ALA light Sensitive agents have the advantages of low toxicity, fast metabolism, and only 1 to 2 days of light-shielding time, and have been widely used in medical clinical treatment. Light-sensitive agents need to receive energy of constant intensity to be stimulated. Therefore, the present invention can accurately control the treatment time of the treatment process by controlling the light power of the light-emitting element 123 or the number of teas such as the light irradiation time, and avoids the discomfort caused by the biological power of the biological 2 (8). side effect. In May, the circuit block diagram of the transmitter of "Figure 2" was read. As shown, the transmit g 110 of the present invention includes a "drive circuit ln" and an oscillating circuit 112. The driving circuit 111 has a -wave generator lm, - is electrically connected to the waveform generator, the k-band 1112, is electrically connected to the frequency divider η, and the inverter mg, the second power 10 200906370 is connected to the opposite The transformers of the device ms are m and the two are respectively electrically connected to the class I power amplifier of the Nawu im (1) 5, and the transformers respectively connected to the class 1 power amplifier 1115]1]6. Wherein, the waveform generator 1U! is used to generate a square wave, which is adjusted by the frequency divider 1112 to the carrier frequency of the specific storage, and then by the reverse (1) 3 card, the square wave is transmitted to the square wave The second modulator is 44 to respectively generate two inverted square wave signals having a constant wave width and amplitude. The square wave signal is transmitted to the transformer 1]16 via the power amplifier 5, and is The conversion of the two transformers 1116 is such that the positive wave signals are respectively outputted by the control signals of the -sine wave and the negative sine wave type. The base circuit 112 of the transmitter 1]0 includes a power source (10) and two sources (10). The transistor 221, and the button is connected to the resonant circuit ms of the transistor, the resonant circuit 1123 has a second inductive coil 1124 electrically connected to the transistor switch, and a capacitor electrically connected to the second inductor 1124 1125. The f-belt, the 9-receiving switch 1122 is configured to respectively receive the control of the transformer 1116 against the other-transistor switch 1122 to perform the opening or closing: the source (10) is turned on according to one of the transistor switches (10). Continuously flowing-current to the resonant circuit 1123, the second residual, and the green ring 1124 are turned on by the capacitor 1125 to generate and emit a wireless signal to the first induction coil 121 to form a magnetic field sensing. coupling. For the use of the "3" F1 "& on circuit block diagram. The light illuminator = the map" stereo illuminator stereoscopic diagram and - electrical, emperor ..., the circuit 122 has a rectifier 1221, connected to the rectifier 1221 and a voltage regulator 1222 of the light-emitting element (2). Control 1] 200906370 The circuit 122 converts the driving signal of the first induction coil into a driving signal, and the driving signal is converted into a 1 by the receiving/generating wireless signal, so that the voltage of the original 1222 is bidirectionally oscillated by the driving signal. The driving signal is converted into a one-way oscillating, but it is maintained by a voltage regulator to maintain a certain range of output values to avoid damage caused by unstable illuminating components. The rectifier 1221 disclosed in the present invention can be a half-wave sizing device, full-wave rectification [or the whole of the bridge rectifier (the fourth), and the technology is already known to the ordinary people of the technology (4), so The inventor does not elaborate here. 'Please continue to refer to the "3rd drawing". The periphery of the light illuminator 20 has a transparent permeable covering material 15G to completely cover the first sensing coil ι2, the control circuit 122, and the illuminating tl member 123. The packaged material 15Q is made of biological (four) materials or glass _, which not only has good biocompatibility, but also has excellent insulation and heat dissipation effect 'avoiding the light illuminator 12Q installed in the body 2 (8), because Excessive heat generated by the operation causes discomfort to the organism 200. Since the light illuminator 120 has excellent biocompatibility, the light illuminator 120 can be taken out from the body of the living body 200 after the end of the treatment, or can be placed in the body 2 (8) for a long time to avoid re-surgery. The inconvenience and the risk that must be borne. As shown in FIG. 1B, the present invention further includes a scattering element 130 coupled to the light-emitting element η], and the scattering element 130 placed in the body of the living body 200 has good biocompatibility 'immunity not to cause the biological 200 Rejection. The scattering element 130 of the present invention is a spherical material having an accommodating space therein, and is filled with a fluid 14 〇 inside the scattering element 130, for example, air, physiological saline, and strontium is 12 200906370 oil-water mixed scale Green (10), the size of the sister silk can be used to protect the fat Ning Ilipoflmdiii) or because of the ancient α- brewing sigh for the practice (four) of the fluid body ^ "4th picture" fine oil and water age · Li Bao fat Ning Jiahan (four) As a description of the basic example, Yanben _ ▲ #, First Fan 仵 12j issued different levels of light: 'The fluid 140 (to.12% of u_- for example) === outward scattering 'The penetration rate of its light is related to the light power = line =!:. The operator can _ real _ heart appropriate light power is large ~,, U evenly illuminate quintugen 0 good effect of photodynamic therapy results. I(10) reduces the cell's and achieves high efficiency and simultaneously compares the element 123 to the scattering element (4). (5) 卞12 items are connected to the surface of the scattering element 13 and the scattering penetration rate is ugly, and the congeal 123 is placed in the scattering. Below the light-emitting element 123 is coupled to the surface of the scattering element, the present invention is based on the form in which the light-emitting elements 23 are coupled to the scattering element D. Radiation reading 1:0 field action confirmation setting touch 2G 峨光光胸胸 in the field can also be shown in the map and $JB®, when the invention is treated, (2) ^ component 123 is equipped with light sensing The device (7) is configured to accumulate the light refracted by the illuminating element, and the optical element 170 emitted by the illuminating element 123 is electrically connected to the control circuit 122 to make the intensity of the illuminating circuit 12, and The optical power analog signal is transmitted to the control private 'for digital demodulation of the signal' and then transmitted to the external demodulator by radio frequency (RF) or micro 200906370 wave temple wireless transmission mode (not shown) In this way, the current luminous intensity is known to assist the medical practitioner in translating the time required for the patient to be irradiated. Or a photo sensor (not shown) is disposed outside the living body 2 (8) of the light illuminator 120. The thyristor is operative to "receive the current state of operation with the wireless signal." For example, the illuminating element 123 is fed back. Whether or not the light is emitted, and the amount of light power of the light, allows the medical practitioner to understand the treatment in the body 2 (8). As shown in Fig. 1B and Fig. 5, in order to observe the internal treatment state, the image capturing device 18G can be installed in the living body 2 (8). The image capturing device 18 is equipped with a processor (8), a third inductive coil (8) electrically connected to the processor 181, an image finder 183, and a wireless transmitter 184. The third induction coil is detached from the wireless signal generated by the second sensing _ 1124, and during the process of illuminating 1J) the stunned creature 2 取, the image finder 183 produces the light generated by the light 2(8) by the light ray. The intensity is shifted to the processor (8) and converted into an output signal, and transmitted to the receiving benefit (not shown) by wireless signal transmission or wireless transmission via wireless signal transmitter 184. The current internal treatment status. ι = In addition, in order to quickly process the output signal generated by the image capture device 18, two antennas (not shown) are added to the light and the radiation 120 to receive and transmit respectively. The signal enables the output signal based on the image signal to be quickly transmitted to the external receiver. The image device 18G can also be incorporated into the light illuminator 12Q without using the third sense = circle 182 'by sharing the control circuit The current generated by 122 is driven to be imaged (8) to make the device disposed in the living body more compact. As shown in the figure, the light illuminator 12 of the present invention further includes a second time 14 200906370 Battery 190, Department Connected to control circuit 122 and a light emitting element technologies, -, snow and the secondary punch 190 having a charge-discharge circuit 191. When one of the control circuits 1 w η,, κ κ robbery broke through the rectification to 1-1, the conversion of the input pressure to 1222 'to the secondary snow pool 3% - into 4 亍 thunder, and then through the outside In a wireless triggering manner, the secondary battery 190 is activated to perform a gas θ 浐 如 ν ν ν ν ν ν ν ν ν ν ν ν ν ν ν τ τ τ τ τ τ τ τ τ τ τ τ τ τ τ τ τ τ τ It can also be treated. -In the middle, start or stop the power output of the secondary battery, which means that the internal code of the different valves, the internal code of the microprocessor, or (4) _ wave signal technology demodulate the external signal, etc. The battery 19 is controlled. "6A" to "6E" are the indications for the application of the sensing device of the present invention to the treatment and diagnosis of organ tissues in various parts of the living body. One of the disclosed inventions can be applied to the treatment of various parts of the human body 200 (organisms), such as the treatment of various organs in the chest, abdomen, and pelvic cavity. According to the present invention, the emitter 110 can be placed in a position relative to the level (10) of the body 11200 by a holder or a holder (10) worn on the human body, so that the emission can be combined with light. Treatment is carried out in the manner of irradiation (4) 0 _ over _ _ wheel. . The holder (10) has a receiving portion 161 for the emitter 110 to be fixed in the center. Moreover, the retaining member can be matched with the body to be treated by the human body, and is designed to be: a cover or a strap, so as to be easily worn by the human body to the position of the light illuminator 120. Ί Order and === 龄 卜 卜 峨 峨 ^ 置于 置于 置于 置于 置于 置于 置于 置于 置于 置于 置于 置于 置于 置于 置于 置于 置于 置于 置于 置于 置于 置于 置于 置于 置于 置于 置于 置于 置于 置于 置于 置于 置于 置于 置于 置于 置于 置于 置于 置于 置于 置于 置于 置于 置于 置于Sensitive agents produce photochemical reactions for the diagnosis or treatment of biopsy. It has improved the inconvenience of the use of the traditional Chinese medicine to promote the use of the oral therapy, and to reduce the risk of bacterial infection. v The invention (4) further maintains the setting, so that the action in the material treatment process will not be restricted by the transmitter, and the light irradiation can be precisely controlled to "power or light irradiation time to slow down" The human body has an uncomfortable feeling during treatment, and at the same time, has the effect of obtaining a better therapeutic effect. Although the embodiments of the present invention are disclosed above, it is not intended to limit the present invention, and those skilled in the art can not deviate from the present invention. Within the spirit and scope, the structure, characteristics and materials described in the context of the invention may be changed as follows: • The patent protection of the present invention is defined by the definition of the scope of interest. BRIEF DESCRIPTION OF THE DRAWINGS FIG. 1 is a plan view of a sensing device of the present invention; FIG. 1 is a side view of a sensing device of the present invention applied to a human body; FIG. 2 is a block diagram of a circuit of the present invention; 3D is a circuit block diagram of a light illuminator of the present invention. FIG. 3C is a circuit block diagram of a light illuminator having a secondary battery of the present invention, and FIG. 4 is the present invention. Inhibition rate The measurement of the penetration scattering rate generated by the fluid of the brain element; 苐5 is a circuit block diagram of the image capturing device of the present invention. The sixth figure is the sensing device applied to the human body. Diagnosis and treatment 16 200906370 side view, Fig. 6B is a side view of the invention for the diagnosis and treatment of the human oral tissue of the sensing device, and Fig. 6C is the diagnosis and treatment of the sensing device of the present invention applied to the human thoracic organ FIG. 6D is a side view showing the diagnosis and treatment of the inductive device of the present invention applied to the human abdominal cavity; and FIG. 6E is a side view showing the diagnosis and treatment of the inductive device of the present invention applied to the human pelvic organs. [Main component symbol description] 100 Induction device 110 Transmitter 111 Driving circuit 1111 Waveform generator 1112 Frequency divider 1113 Inverter 1114 Modulator 1115 Power amplifier 1116 Transformer 112 Oscillation circuit 1121 Power supply 1122 Transistor switch 1123 Resonance circuit 17 200906370 1124 second mouse should coil 1125 capacitor 120 light illuminator 121 first induction coil 122 control circuit 1221 Rectifier 1222 Stabilizer Illumination Element Scattering Element 140 Fluid 150 Cladding Material 160 Protection Device 161 Capacitor 170 Photosensor 180 Image Acquisition Device 181 Processor 182 Third Induction Coil 183 Imager 184. Wireless Signal Transmitter 190 Secondary Battery 191 Charge and Discharge Circuit 200 Bio 18

Claims (1)

200906370 十、申請專刮範圍: 1. 一種應兩於光動力診斷與治療+咸 上,用以激發該生物體門之夫#二應,係使吊於-生物 應裝置包括有: '及樂劑產生光化學反應,該感 一發射器,用以發出—穿透註江 一光照射器,係設置料仏病表狀無軌號;以及 、这生物體内,1呈右. —第一感應線圈, -mm 錢科線訊號; 才工μ电路,電性連接於 線訊號轉換為一驅動訊穿;、μ罘—感應線圈,並將該無 化,以及 —發光元件,電性遑接於 該驢動訊號驅動而發出光'“電路,該發光元样由 學反應。 、以使該光敏感藥劑產生光化 2·如申請專利範圍f旧所述之應 裝置,其中該發射器包含有1動•動力診斷與治療之感應 電路係用以產生-控制訊號,該及一震盧電路,該驅動 電路,以將該控制訊號轉換為該^電路係電性連接於該驅動 3·如申請專利範圍第2項所述之庳用亚發出。 襄置,其中該驅動電路更包含一於光動力診斷與治療之感應 該波形產生器之除頻器 '—電^形產生器、-電性連接於 少-電性連接於該反向器之調^接於該除頻器之反向器、至 器、之功率放大器、以及至少— 1—紐連接於該調變 器,以產生該控制訊號。^連接於該功率放大器之變壓 4·如申請翻範_2摘敎應 19^ 、光動力診斷與治療之感應 200906370 裝呈’其〒該震覆電路更包含有-電源、i少—雷— 電源之電晶體開關、及一電性連細於該 路’該電晶體開關接收該控制訊 二、共振電 _無線訊敍舞1麟圈。略發出該 範鷗4項所述之翩於光動力診斷 =,其中該共振電路具有一第二感應線圈及—電容= u請m連接於該電晶體關, 二感應線圈’且該第二_由該電容之充二穴接於= 該無線訊號至該第一感應線圈。 文紅用,以發出 柄細嫩力糊轉之感應 射元件岐/ w雛於該發光元叙散射轉,且該散 散射、"—容置空間,並填裝有一流體,以使該光線產生 :申請,第6項所述之應用於光動力診斷與治療之感應 =,八中該流體係選自於由空氣、生理食鹽水、及油水混合 物所構成之群組。 2請專纖圍第7項所述之制於光動力診斷與治療之感應 =,其巾該油水混合物係為力絲寧(lipaftmdin)或是因特立 滋(intralipid)。 申凊專纖圍第i項所述之應用於絲力診斷與治療之感應 衣’射該控制電路具有—整流器及―穩㈣,該整流器用 二接收該驅動訊號,該穩壓器電性連接該整流器及該發光元 件,以對該驅動訊號整流及穩壓。 20 200906370 i〇.如由請專到範圍第i項所述之應·於光動力診斷輿治療之感應 裝置,其中更包括有一包覆於該光照射器外圍並具有生物相容 性之包覆#料,以使該光照射器絕緣及散熱。 11. 如申請專利範圍第10項所述之應用於光動力診斷與治療之感 應裝置^兴中該包覆4才料係為硬膠材料或是玻璃朽不〒。 12. 如申請專利範圍第1項所述之應用於光動力診斷與治療之感應 裝置,其中該發光元件係為發光二極體或是雷射二極體。 13. 如申請專利範圍第1項所述之應用於光動力診斷與治療之感應 裝置,其中更包含有一保持件,且該保持件具有一容設部,以 固定該發射器於該保持件上。 14. 如申請專利範圍第1項所述之應用於光動力診斷與治療之感應 裝置,其中更包含有一光感測器,係電性連接於該控制電路, 用以於該發光元件發出該光線時,偵測該光線之強度,並傳送 至該控制電路。 15. 如申請專利範圍第1項所述之應用於光動力診斷與治療之感應 裝置,其中更包含有一取像裝置,其具有: 一處理器; 一第三感應線圈,電性連接於該處理器,用以接收該無線 訊號,並驅動該處理器; 一取像器,電性連接於該處理器,用以偵測該生物藉由該 光線所產生之光強度,並藉由該處理器轉換為一輸出訊號;以 及 一無線訊號發射器,電性連接於該處理器,用以發射該輸 21 200906370 訊號 i6_如申請麵範圍gi項所述之制於 裝置,其中該光照射器更包括有-二興治療之感應 制電路及_歧#,以提供—魏封=時钱該控 "•如申請細第16項所述之_ ^沾。 應裝置,其中該二次電池更具有一充放^力診斷與治療之感 籍由該控制電路之鶴訊號,以對該二該充放電迴路 18·—種廊用认上 电'也進行充電。 ‘ ^用灰疋劫力診斷與治療之光照射哭 内,該光照射器藉由-穿透該生物表層二f置於一生物體 線,以、如4訊號而發出一光 紙㈣生物體内之綠财 射器包括有: 上九亿争反應,該光照 第—感應線圈,用以接收該無線訊替. 號轉r=’m連接於該第―_二,並將該無線訊 L粉換為一驅動訊號;以及 動=讀’電性連接於該㈣魏,雜光元件由該驅 錢該光敏_财生絲學反應。 照射器,並人、所逃之應用於光動力診斷與治療之光 散射Γ =匕3 —銜接於該發歧叙雜元件,且該 /射70件内填裝有—流體,以使該光線產生散射。 销叙應祕絲力辑與治療之光 物所構成之群組。、自由生理健水、及油水混合 此如申物刪2Q _物祕咖軸治療之光 22 200906370 照射器,其中該治水混合物係為力保肪寧土C :或是因特 立滋(intraiipid) c 22. 如申請專利範圍第18項所述之應闬於光動力診斷與治療之光 照射器,其中該控制電路具有一整流器及一穩壓器,該整流器 係電性連接該第一感應線圈,該穩壓器電性連接該整流器及該 發光元件,以對該驅動訊號整流及穩壓。 23. 如申請專利範圍第18項所述之應用於光動力診斷與治療之光 照射器,其中更包括有一包覆於該發光器外圍並具有生物相容 性之包覆材料,以使該發光器絕緣及散熱。 24. 如申請專利範圍第23項所述之應用於光動力診斷與治療之光 照射器'其中該包覆材料係為碎躍、材料或是玻璃枯料。 25. 如申請專利範圍第18項所述之應用於光動力診斷與治療之光 照射器,其中該發光元件係為發光二極體或是雷射二極體。200906370 X. Application for special scraping range: 1. A kind of photodynamic diagnosis and treatment + salty, used to stimulate the body of the door. #二应,系使吊- biological device includes: '和乐The agent generates a photochemical reaction, and the sensor is used to emit a penetrating injection beam, which is provided with a sputum-like trackless track number; and, in the living body, 1 is a right-first induction coil. -mm money line signal; the power circuit, the electrical connection to the line signal is converted into a driver signal; the μ罘-induction coil, and the non-inductive, and - the light-emitting element, electrically connected to the The signal is driven to emit a light ''circuit, the illuminating element is reacted to cause the light-sensitive agent to produce actin. 2. The device as described in the patent application scope f, wherein the transmitter includes 1 action • The power diagnosis and treatment sensing circuit is used to generate a control signal, and a vibration circuit, the driving circuit is configured to convert the control signal into the circuit, and the circuit is electrically connected to the driving device. The application mentioned in item 2 The driving circuit further includes a frequency divider for detecting the waveform generator in the photodynamic diagnosis and treatment, the electrical generator is electrically connected to the electrical connection to the reverse The inverter is connected to the inverter, the inverter, the power amplifier, and at least the 1-connector is connected to the modulator to generate the control signal. The voltage is connected to the power amplifier. 4. If you apply for a model _2 excerpt should be 19 ^, photodynamic diagnosis and treatment of the induction 200906370 installed 'the 震 震 震 震 震 震 震 震 震 震 震 震 震 震 震 震 震 震 震 震 震 震 震 震 震 震 震 震 震 震 震 震 震 震 震 震Electrical connection is finer than the road 'The transistor switch receives the control signal 2, the resonance power _ wireless communication and dance 1 lining. Slightly issued the Fan Gu 4 item described in the photodynamic diagnosis =, wherein the resonant circuit Having a second induction coil and a capacitor = u, m is connected to the transistor, the second induction coil 'and the second _ is connected to the second signal by the capacitor to the first induction coil. Red, used to send the handle to the tenderness of the inductive element 岐 / w chick The illuminating element is scattered and scattered, and the space is filled with a fluid to generate the light: the application, the sensing of the photodynamic diagnosis and treatment described in Item 6 The eight-stream system is selected from the group consisting of air, physiological saline, and oil-water mixture. 2 Please refer to the induction of photodynamic diagnosis and treatment described in Item 7 of the special fiber. The mixture is a lipaftmdin or an intralipid. The induction garment for the diagnosis and treatment of silk force described in item i of the application of the 凊 凊 ' ' 射 射 该 该 控制 控制 控制 控制 控制 该 该 该 该 该 该 该 该 该 该 该 该Steady (four), the rectifier receives the driving signal by two, the voltage regulator is electrically connected to the rectifier and the light emitting component to rectify and stabilize the driving signal. 20 200906370 i〇. If you are interested in the scope of the scope of the i, in the photodynamic diagnosis of 舆 treatment of the sensing device, which further includes a coating coated on the periphery of the light illuminator and biocompatible #料, in order to make the light illuminator insulated and heat. 11. The application device for photodynamic diagnosis and treatment described in claim 10 of the patent application is in the form of a hard rubber material or a glass. 12. The inductive device for photodynamic diagnosis and treatment according to claim 1, wherein the illuminating element is a light emitting diode or a laser diode. 13. The sensing device for photodynamic diagnosis and treatment according to claim 1, further comprising a holder, and the holder has a receiving portion for fixing the emitter on the holder . 14. The sensing device for photodynamic diagnosis and treatment according to claim 1, further comprising a light sensor electrically connected to the control circuit for emitting the light to the light emitting component The intensity of the light is detected and transmitted to the control circuit. 15. The sensing device for photodynamic diagnosis and treatment according to claim 1, further comprising an image capturing device, comprising: a processor; a third inductive coil electrically connected to the processing The device is configured to receive the wireless signal and drive the processor; an image capture device is electrically connected to the processor for detecting the light intensity generated by the light by the light, and by using the processor Converting to an output signal; and a wireless signal transmitter electrically coupled to the processor for transmitting the transmission 21 200906370 signal i6_ as described in the application of the scope of the item gi, wherein the light illuminator is further Including the sensor circuit and _Q# for the treatment of -2, in order to provide - Wei Feng = when the money is controlled " • as described in the application of the 16th item. The device should have a device, wherein the secondary battery has a sense of charge and discharge diagnosis and treatment, and the control signal is used by the crane signal to charge the charging and discharging circuit 18· . ' ^ Use the light of the gray robbing power to diagnose and treat the crying, the light illuminator is placed on a biological line by penetrating the biological surface layer, and a light paper (4) is emitted in the living body. The green radiator includes: a 900 million contending reaction, the illumination first-inductive coil for receiving the wireless relay. The number is rotated r='m is connected to the first _2, and the wireless L powder is Switched to a drive signal; and move = read 'electrically connected to the (four) Wei, the stray light component by the drive to the photosensitive _ 财生丝学 reaction. The illuminator, the light scatter 应用于 = 匕 3 - applied to the photodynamic diagnosis and treatment, is connected to the anamorphic component, and the 70 element is filled with a fluid to make the light Scattering occurs. The sales group consists of a secret and a therapeutic light. Free physiology and water, and oil and water mixed with this product as a deletion 2Q _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ c 22. The light illuminator for photodynamic diagnosis and treatment according to claim 18, wherein the control circuit has a rectifier and a voltage regulator, and the rectifier is electrically connected to the first induction coil The voltage regulator is electrically connected to the rectifier and the light emitting component to rectify and stabilize the driving signal. 23. The light illuminator for photodynamic diagnosis and treatment according to claim 18, further comprising a coating material coated on the periphery of the illuminator and having biocompatibility to enable the illuminating Insulation and heat dissipation. 24. A light illuminator for use in photodynamic diagnosis and treatment as described in claim 23, wherein the coating material is a smash, material or glass. 25. The light illuminator for photodynamic diagnosis and treatment according to claim 18, wherein the illuminating element is a light emitting diode or a laser diode.
TW96128310A 2007-08-01 2007-08-01 Sensing device applied in photodynamic therapy and diagnosis TW200906370A (en)

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