TW200730513A - Carbamoylbenzotriazole derivatives as inhibitors of lipases and phospholipases - Google Patents

Carbamoylbenzotriazole derivatives as inhibitors of lipases and phospholipases

Info

Publication number: TW200730513A
Authority: TW; Taiwan
Prior art keywords: phospholipases; lipases; inhibitors; derivatives; carbamoylbenzotriazole
Prior art date: 2005-10-19

Application number

TW095138145A

Other languages

English (en)

Inventor

Stefan Petry

Gerhard Zoller

Norbert Tennagels

Guenter Mueller

Original Assignee

Sanofi Aventis Deutschland

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2005-10-19

Filing date

2006-10-17

Publication date

2007-08-16

2006-10-17 Application filed by Sanofi Aventis Deutschland filed Critical Sanofi Aventis Deutschland

2007-08-16 Publication of TW200730513A publication Critical patent/TW200730513A/zh

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/16—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms condensed with carbocyclic rings or ring systems
- C07D249/18—Benzotriazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4192—1,2,3-Triazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Diabetes (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Obesity (AREA)
Hematology (AREA)
Endocrinology (AREA)
Emergency Medicine (AREA)
Heart & Thoracic Surgery (AREA)
Vascular Medicine (AREA)
Cardiology (AREA)
Urology & Nephrology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Enzymes And Modification Thereof (AREA)

TW095138145A 2005-10-19 2006-10-17 Carbamoylbenzotriazole derivatives as inhibitors of lipases and phospholipases TW200730513A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE102005049953A DE102005049953A1 (de)	2005-10-19	2005-10-19	Carbamoylbenzotriazol-derivate als Inhibitoren von Lipasen und Phospholipasen

Publications (1)

Publication Number	Publication Date
TW200730513A true TW200730513A (en)	2007-08-16

Family

ID=37667178

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
TW095138145A TW200730513A (en)	2005-10-19	2006-10-17	Carbamoylbenzotriazole derivatives as inhibitors of lipases and phospholipases

Country Status (26)

Country	Link
US (2)	US7897625B2 (zh)
EP (1)	EP1940807B1 (zh)
JP (1)	JP2009512650A (zh)
KR (1)	KR20080063474A (zh)
CN (1)	CN101291918A (zh)
AR (1)	AR057554A1 (zh)
AU (1)	AU2006303552A1 (zh)
BR (1)	BRPI0617613A2 (zh)
CA (1)	CA2625722A1 (zh)
CR (1)	CR9850A (zh)
DE (1)	DE102005049953A1 (zh)
DO (1)	DOP2006000226A (zh)
EC (1)	ECSP088377A (zh)
GT (1)	GT200600463A (zh)
HN (1)	HN2006035238A (zh)
IL (1)	IL190714A0 (zh)
MA (1)	MA29858B1 (zh)
NO (1)	NO20081942L (zh)
NZ (1)	NZ567573A (zh)
PE (1)	PE20070724A1 (zh)
RU (1)	RU2430096C2 (zh)
TN (1)	TNSN08177A1 (zh)
TW (1)	TW200730513A (zh)
UY (1)	UY29872A1 (zh)
WO (1)	WO2007045393A1 (zh)
ZA (1)	ZA200802370B (zh)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU2007305269A1 (en) *	2006-10-04	2008-04-10	Schering Corporation	Bicyclic and tricyclic derivatives as thrombin receptor antagonists
EP2025674A1 (de)	2007-08-15	2009-02-18	sanofi-aventis	Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
WO2010003624A2 (en)	2008-07-09	2010-01-14	Sanofi-Aventis	Heterocyclic compounds, processes for their preparation, medicaments comprising these compounds, and the use thereof
WO2010044441A1 (ja)	2008-10-17	2010-04-22	塩野義製薬株式会社	血管内皮リパーゼ阻害活性を有する酢酸アミド誘導体
MX342128B (es) *	2008-12-24	2016-09-14	Bial - Portela & C A S A	Compuestos farmaceuticos.
WO2011022312A1 (en) *	2009-08-20	2011-02-24	Merck Sharp & Dohme Corp.	Ether benzotriazole derivatives
WO2011074560A1 (ja)	2009-12-15	2011-06-23	塩野義製薬株式会社	血管内皮リパーゼ阻害活性を有するオキサジアゾール誘導体
US8450350B2 (en) *	2010-05-05	2013-05-28	Infinity Pharmaceuticals, Inc.	Triazoles as inhibitors of fatty acid synthase
WO2011157827A1 (de)	2010-06-18	2011-12-22	Sanofi	Azolopyridin-3-on-derivate als inhibitoren von lipasen und phospholipasen
WO2012047580A1 (en) *	2010-09-27	2012-04-12	Janssen Pharmaceutica Nv	Alpha-ketoamide derivatives useful endothelial lipase inhibitors
DK3019482T3 (en)	2013-02-25	2018-11-12	Aurigene Discovery Tech Ltd	TRISUBSTITUTED BENZOETRIAZOLD DERIVATIVES AS DIHYDROORO-TATOXYGENASE INHIBITORS
RU2563254C2 (ru) *	2013-07-08	2015-09-20	Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Московский государственный университет имени М.В. Ломоносова" (МГУ)	Способ получения производных 7-(гетеро)арил-4,5,6,7-тетрагидро[1,2,3]триазоло[1,5-a]пиридина
RU2553987C1 (ru) *	2013-12-26	2015-06-20	Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Санкт-Петербургский государственный университет" (СПбГУ)	N-адамантилбензотриазолы, проявляющие активность против вируса гриппа а, и способ их получения
CN104292172B (zh) *	2014-09-12	2016-08-17	浙江理工大学	一种苯并三氮唑类衍生物及其制备方法
SG11201909718QA (en) *	2017-04-24	2019-11-28	Aurigene Discovery Tech Ltd	Methods of use for trisubstituted benzotriazole derivatives as dihydroorotate oxygenase inhibitors
US20180369206A1 (en)	2017-04-24	2018-12-27	Aurigene Discovery Technologies Limited	Methods of Use for Trisubstituted Benzotriazole Derivatives as Dihydroorotate Oxygenase Inhibitors
MA51897A (fr)	2018-02-20	2020-12-30	Agios Pharmaceuticals Inc	Procédés d'utilisation de dérivés de benzotriazole trisubstitués

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA1035188A (en) *	1974-08-15	1978-07-25	Eastman Kodak Company	Blocked development restrainers
US4273860A (en) *	1977-12-28	1981-06-16	Eastman Kodak Company	Inhibition of image formation utilizing cobalt(III) complexes
CA1124716A (en)	1978-10-20	1982-06-01	Michael J. Simons	Blocked benzotriazole compounds as development restrainer precursors
JPS6239573A (ja) *	1985-08-13	1987-02-20	Sumitomo Chem Co Ltd	シクロアルケニルアミド誘導体、その製造法およびそれを有効成分とする土壌病害防除剤
US6372421B1 (en) *	2000-06-13	2002-04-16	Eastman Kodak Company	Photothermographic imaging element having improved contrast and methods of image formation
US6440648B1 (en) *	2000-06-13	2002-08-27	Eastman Kodak Company	Color photographic element having improved contrast and compatibility with both dry and conventional processing
WO2002090355A1 (en)	2001-05-05	2002-11-14	Smithkline Beecham P.L.C.	N-aroyl cyclic amines
CN1326519C (zh)	2001-12-14	2007-07-18	诺沃挪第克公司	化合物及其降低激素－敏感性脂肪酶活性的用途
DE10247680B4 (de) *	2002-10-12	2005-09-01	Aventis Pharma Deutschland Gmbh	Neue bicyclische Inhibitoren der Hormon Sensitiven Lipase
WO2004093872A1 (en) *	2003-03-31	2004-11-04	Eli Lilly And Company	3-oxo-1, 3-dihydro-indazole-2-carboxylic acid amide derivatives as phospholipase inhibitors

2005
- 2005-10-19 DE DE102005049953A patent/DE102005049953A1/de not_active Ceased
2006
- 2006-10-12 EP EP06806216.5A patent/EP1940807B1/de active Active
- 2006-10-12 CA CA002625722A patent/CA2625722A1/en not_active Abandoned
- 2006-10-12 CN CNA2006800384397A patent/CN101291918A/zh active Pending
- 2006-10-12 JP JP2008535942A patent/JP2009512650A/ja not_active Abandoned
- 2006-10-12 AU AU2006303552A patent/AU2006303552A1/en not_active Abandoned
- 2006-10-12 RU RU2008119460/04A patent/RU2430096C2/ru not_active IP Right Cessation
- 2006-10-12 WO PCT/EP2006/009857 patent/WO2007045393A1/de active Application Filing
- 2006-10-12 BR BRPI0617613-5A patent/BRPI0617613A2/pt not_active IP Right Cessation
- 2006-10-12 KR KR1020087009298A patent/KR20080063474A/ko not_active Application Discontinuation
- 2006-10-12 NZ NZ567573A patent/NZ567573A/en not_active IP Right Cessation
- 2006-10-17 GT GT200600463A patent/GT200600463A/es unknown
- 2006-10-17 DO DO2006000226A patent/DOP2006000226A/es unknown
- 2006-10-17 TW TW095138145A patent/TW200730513A/zh unknown
- 2006-10-17 PE PE2006001257A patent/PE20070724A1/es not_active Application Discontinuation
- 2006-10-17 AR ARP060104521A patent/AR057554A1/es unknown
- 2006-10-18 HN HN2006035238A patent/HN2006035238A/es unknown
- 2006-10-18 UY UY29872A patent/UY29872A1/es not_active Application Discontinuation
2008
- 2008-03-13 ZA ZA200802370A patent/ZA200802370B/xx unknown
- 2008-03-28 CR CR9850A patent/CR9850A/es not_active Application Discontinuation
- 2008-04-08 MA MA30825A patent/MA29858B1/fr unknown
- 2008-04-08 IL IL190714A patent/IL190714A0/en unknown
- 2008-04-09 US US12/099,924 patent/US7897625B2/en not_active Expired - Fee Related
- 2008-04-17 EC EC2008008377A patent/ECSP088377A/es unknown
- 2008-04-18 TN TNP2008000177A patent/TNSN08177A1/en unknown
- 2008-04-23 NO NO20081942A patent/NO20081942L/no not_active Application Discontinuation
2011
- 2011-01-20 US US13/009,951 patent/US20110118321A1/en not_active Abandoned

Also Published As

Publication number	Publication date
DOP2006000226A (es)	2007-05-15
HN2006035238A (es)	2010-05-24
ZA200802370B (en)	2008-12-31
DE102005049953A1 (de)	2007-04-26
GT200600463A (es)	2007-05-21
NZ567573A (en)	2010-06-25
CA2625722A1 (en)	2007-04-26
CR9850A (es)	2008-06-18
EP1940807B1 (de)	2015-06-17
US20110118321A1 (en)	2011-05-19
NO20081942L (no)	2008-04-23
AU2006303552A1 (en)	2007-04-26
AR057554A1 (es)	2007-12-05
MA29858B1 (fr)	2008-10-03
BRPI0617613A2 (pt)	2011-08-02
TNSN08177A1 (en)	2009-10-30
JP2009512650A (ja)	2009-03-26
ECSP088377A (es)	2008-05-30
CN101291918A (zh)	2008-10-22
RU2430096C2 (ru)	2011-09-27
RU2008119460A (ru)	2009-11-27
UY29872A1 (es)	2007-05-31
US20080287503A1 (en)	2008-11-20
EP1940807A1 (de)	2008-07-09
IL190714A0 (en)	2008-11-03
PE20070724A1 (es)	2007-08-07
WO2007045393A1 (de)	2007-04-26
KR20080063474A (ko)	2008-07-04
US7897625B2 (en)	2011-03-01

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