TW200716548A - Process for the preparation of opioid modulators - Google Patents

Process for the preparation of opioid modulators

Info

Publication number: TW200716548A
Authority: TW; Taiwan
Prior art keywords: preparation; opioid modulators; opioid; modulators; agonists
Prior art date: 2005-03-14

Application number

TW095108512A

Other languages

English (en)

Other versions

TWI414518B (zh

Inventor

chao-zhong Cai

Wei He

Original Assignee

Janssen Pharmaceutica Nv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2005-03-14

Filing date

2006-03-14

Publication date

2007-05-01

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36646011&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=TW200716548(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2006-03-14 Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv

2007-05-01 Publication of TW200716548A publication Critical patent/TW200716548A/zh

2013-11-11 Application granted granted Critical

2013-11-11 Publication of TWI414518B publication Critical patent/TWI414518B/zh

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/10—Laxatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/02—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
- C07C233/11—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to carbon atoms of an unsaturated carbon skeleton containing six-membered aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/14—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being saturated and containing rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
- C07D233/61—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms not forming part of a nitro radical, attached to ring nitrogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Pain & Pain Management (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Rheumatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Optical Modulation, Optical Deflection, Nonlinear Optics, Optical Demodulation, Optical Logic Elements (AREA)
Crystals, And After-Treatments Of Crystals (AREA)

TW095108512A 2005-03-14 2006-03-14 製備類鴉片調節劑之方法（一） TWI414518B (zh)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US66178405P	2005-03-14	2005-03-14
US11/368,588 US20060211861A1 (en)	2005-03-14	2006-03-06	Process for the preparation of opioid modulators

Publications (2)

Publication Number	Publication Date
TW200716548A true TW200716548A (en)	2007-05-01
TWI414518B TWI414518B (zh)	2013-11-11

Family

ID=36646011

Family Applications (3)

Application Number	Title	Priority Date	Filing Date
TW101129655A TWI500595B (zh)	2005-03-14	2006-03-14	製備類鴉片調節劑之方法（一）
TW095108512A TWI414518B (zh)	2005-03-14	2006-03-14	製備類鴉片調節劑之方法（一）
TW095108513A TW200700388A (en)	2005-03-14	2006-03-14	Process for the preparation of opioid modulators

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
TW101129655A TWI500595B (zh)	2005-03-14	2006-03-14	製備類鴉片調節劑之方法（一）

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
TW095108513A TW200700388A (en)	2005-03-14	2006-03-14	Process for the preparation of opioid modulators

Country Status (30)

Country	Link
US (4)	US7629488B2 (zh)
EP (2)	EP1858850B1 (zh)
JP (3)	JP5384933B2 (zh)
KR (2)	KR20070112255A (zh)
CN (2)	CN101175726A (zh)
AR (2)	AR053170A1 (zh)
AU (2)	AU2006223394B2 (zh)
BR (2)	BRPI0607793A2 (zh)
CA (2)	CA2601674A1 (zh)
CR (1)	CR9438A (zh)
CY (1)	CY1116104T1 (zh)
DK (1)	DK1858850T3 (zh)
EA (2)	EA015512B1 (zh)
ES (1)	ES2535048T3 (zh)
HR (1)	HRP20150417T1 (zh)
HU (1)	HUE024912T2 (zh)
IL (3)	IL185974A0 (zh)
ME (1)	ME02110B (zh)
MX (2)	MX2007011412A (zh)
MY (1)	MY145333A (zh)
NI (1)	NI200700237A (zh)
NO (2)	NO20075268L (zh)
NZ (1)	NZ590570A (zh)
PL (1)	PL1858850T3 (zh)
PT (1)	PT1858850E (zh)
RS (1)	RS53873B1 (zh)
SI (1)	SI1858850T1 (zh)
TW (3)	TWI500595B (zh)
WO (2)	WO2006098982A1 (zh)
ZA (2)	ZA200708810B (zh)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7041681B2 (en) *	2002-04-29	2006-05-09	Janssen Pharmaceutica N.V.	Compounds as opioid receptor modulators
HUE029852T2 (en) *	2004-03-15	2017-04-28	Janssen Pharmaceutica Nv	Opioid receptor modulators
NZ590570A (en) *	2005-03-14	2012-06-29	Janssen Pharmaceutica Nv	Process for the preparation of opioid modulators
CN101730685A (zh)	2007-07-09	2010-06-09	詹森药业有限公司	5-({[2-氨基-3-(4-氨甲酰基-2,6-二甲基-苯基)-丙酰基]-[1-(4-苯基-1h-咪唑-2-基)-乙基]-氨基}-甲基)-2-甲氧基-苯甲酸的新型晶体及其制备方法
TWI468375B (zh) *	2008-10-27	2015-01-11	Janssen Pharmaceutica Nv	製備經保護之ｌ－丙胺酸衍生物之方法
IS2977B (is)	2015-02-23	2017-07-15	Actavis Group Ptc Ehf.	Aðferð til framleiðslu á milliefnum sem eru nytsamleg við nýsmíði á elúxadólíni
WO2017043626A1 (ja) *	2015-09-11	2017-03-16	株式会社カネカ	光学活性４－カルバモイル－２，６－ジメチルフェニルアラニン誘導体の製造法
CN105777584B (zh) *	2016-03-28	2018-01-02	成都伊诺达博医药科技有限公司	丙氨酸衍生物的制备方法
CN105693554B (zh) *	2016-04-06	2017-08-08	成都伊诺达博医药科技有限公司	丙氨酸衍生物的制备方法
US10822308B2 (en) *	2016-06-23	2020-11-03	Sun Pharmaceutical Industries Limited	Processes for the preparation of eluxadoline
WO2018047131A1 (en) *	2016-09-09	2018-03-15	Sun Pharmaceutical Industries Limited	Amorphous eluxadoline
WO2018055528A2 (en)	2016-09-20	2018-03-29	Sun Pharmaceutical Industries Limited	Processes for the preparation of eluxadoline
CN106866463B (zh) *	2017-01-24	2018-08-28	富乐马鸿凯（大连）医药有限公司	艾沙度林中间体的制备方法
US10738013B2 (en)	2017-01-27	2020-08-11	Quimica Sintetica, S.A.	Eluxadoline crystalline forms and processes for their preparation
WO2018138272A1 (en)	2017-01-27	2018-08-02	Quimica Sintetica, S. A.	Eluxadoline crystalline form and process for the preparation thereof
CN111377832A (zh) *	2018-12-27	2020-07-07	江苏联昇化学有限公司	一种伊卢多啉中间体制备的新方法
EP4129402A4 (en)	2020-03-31	2024-06-12	Mitsubishi Tanabe Pharma Corporation	HYDROXYPYRROLIDINE DERIVATIVE AND ITS MEDICINAL APPLICATION
CN114163348A (zh) *	2020-11-27	2022-03-11	成都泰蓉生物科技有限公司	一种氨酰基取代的l-苯丙氨酸的合成方法
CN114507252B (zh) *	2022-02-21	2023-10-27	广西大学	新型芳基硅烷化合物的合成方法

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JPS5430129A (en) *	1977-08-09	1979-03-06	Mitsubishi Gas Chem Co Inc	Preparation of toluic acid amide
JPS5528959A (en) *	1978-08-22	1980-02-29	Sumitomo Chem Co Ltd	Production of amide derivative
FR2584401B1 (fr) *	1985-07-04	1987-11-20	Ile De France	Nouveau benzamide, son procede de preparation et son application dans le domaine therapeutique
JP2727243B2 (ja) *	1988-12-27	1998-03-11	日本化薬株式会社	２−アシルアミノ桂皮酸誘導体の製造法
US5684175A (en) *	1993-02-05	1997-11-04	Napro Biotherapeutics, Inc.	C-2' hydroxyl-benzyl protected, N-carbamate protected (2R, 3S)- 3-phenylisoserine and production process therefor
JP3493206B2 (ja) *	1993-03-19	2004-02-03	ダイセル化学工業株式会社	光学活性β−アミノ酸類の製法
JP3486922B2 (ja) *	1993-08-23	2004-01-13	住友化学工業株式会社	酸アミドの製造法
CN1225471C (zh) *	1995-01-27	2005-11-02	诺沃挪第克公司	具有生长激素释放特性的化合物
JPH09295939A (ja) *	1995-09-26	1997-11-18	Takeda Chem Ind Ltd	リン酸アミド誘導体、その製造法および用途
PT1062201E (pt) *	1998-03-11	2005-02-28	Searle & Co	Derivados halogenados de amidino-aminoacidos uteis como inibidores da sintase do acido nitrico
ES2206139T3 (es) *	1999-05-28	2004-05-16	Pfizer Products Inc.	Derivados de 3-(3-hidrofenil)-3-amino-propionamida.
DE60128731T2 (de) *	2000-10-30	2008-02-07	Janssen Pharmaceutica N.V.	Tripeptidylpeptidase-hemmer
US7041681B2 (en) *	2002-04-29	2006-05-09	Janssen Pharmaceutica N.V.	Compounds as opioid receptor modulators
HUE029852T2 (en) *	2004-03-15	2017-04-28	Janssen Pharmaceutica Nv	Opioid receptor modulators
NZ590570A (en) *	2005-03-14	2012-06-29	Janssen Pharmaceutica Nv	Process for the preparation of opioid modulators

2006
- 2006-03-06 NZ NZ590570A patent/NZ590570A/en not_active IP Right Cessation
- 2006-03-06 AU AU2006223394A patent/AU2006223394B2/en not_active Ceased
- 2006-03-06 EP EP06737611.1A patent/EP1858850B1/en active Active
- 2006-03-06 ES ES06737611.1T patent/ES2535048T3/es active Active
- 2006-03-06 JP JP2008501919A patent/JP5384933B2/ja not_active Expired - Fee Related
- 2006-03-06 MX MX2007011412A patent/MX2007011412A/es active IP Right Grant
- 2006-03-06 MX MX2007011409A patent/MX2007011409A/es unknown
- 2006-03-06 DK DK06737611.1T patent/DK1858850T3/en active
- 2006-03-06 RS RS20150121A patent/RS53873B1/en unknown
- 2006-03-06 ME MEP-2015-31A patent/ME02110B/me unknown
- 2006-03-06 BR BRPI0607793-5A patent/BRPI0607793A2/pt not_active Application Discontinuation
- 2006-03-06 WO PCT/US2006/008240 patent/WO2006098982A1/en active Application Filing
- 2006-03-06 WO PCT/US2006/008450 patent/WO2006099060A2/en active Application Filing
- 2006-03-06 CN CNA2006800166320A patent/CN101175726A/zh active Pending
- 2006-03-06 US US11/368,564 patent/US7629488B2/en active Active
- 2006-03-06 KR KR1020077023282A patent/KR20070112255A/ko not_active Ceased
- 2006-03-06 CA CA002601674A patent/CA2601674A1/en not_active Abandoned
- 2006-03-06 EA EA200701978A patent/EA015512B1/ru unknown
- 2006-03-06 HU HUE06737611A patent/HUE024912T2/en unknown
- 2006-03-06 EP EP06737413A patent/EP1863764A1/en not_active Withdrawn
- 2006-03-06 BR BRPI0607792-7A patent/BRPI0607792A2/pt not_active IP Right Cessation
- 2006-03-06 KR KR1020077022664A patent/KR101280929B1/ko not_active Expired - Fee Related
- 2006-03-06 PL PL06737611T patent/PL1858850T3/pl unknown
- 2006-03-06 PT PT67376111T patent/PT1858850E/pt unknown
- 2006-03-06 JP JP2008501912A patent/JP2008533141A/ja not_active Withdrawn
- 2006-03-06 EA EA200701979A patent/EA014366B1/ru not_active IP Right Cessation
- 2006-03-06 SI SI200631907T patent/SI1858850T1/sl unknown
- 2006-03-06 US US11/368,588 patent/US20060211861A1/en not_active Abandoned
- 2006-03-06 AU AU2006223482A patent/AU2006223482A1/en not_active Abandoned
- 2006-03-06 CN CN2006800163712A patent/CN101175725B/zh not_active Expired - Fee Related
- 2006-03-06 CA CA2601481A patent/CA2601481C/en active Active
- 2006-03-14 TW TW101129655A patent/TWI500595B/zh not_active IP Right Cessation
- 2006-03-14 TW TW095108512A patent/TWI414518B/zh not_active IP Right Cessation
- 2006-03-14 AR ARP060100974A patent/AR053170A1/es not_active Application Discontinuation
- 2006-03-14 TW TW095108513A patent/TW200700388A/zh unknown
- 2006-03-14 AR ARP060100973A patent/AR054745A1/es active IP Right Grant
- 2006-03-14 MY MYPI20061110A patent/MY145333A/en unknown
2007
- 2007-09-13 NI NI200700237A patent/NI200700237A/es unknown
- 2007-09-16 IL IL185974A patent/IL185974A0/en unknown
- 2007-09-16 IL IL185972A patent/IL185972A/en active IP Right Grant
- 2007-10-12 CR CR9438A patent/CR9438A/es not_active Application Discontinuation
- 2007-10-12 ZA ZA200708810A patent/ZA200708810B/xx unknown
- 2007-10-12 ZA ZA200708809A patent/ZA200708809B/xx unknown
- 2007-10-15 NO NO20075268A patent/NO20075268L/no not_active Application Discontinuation
- 2007-10-15 NO NO20075269A patent/NO340604B1/no not_active IP Right Cessation
2009
- 2009-10-16 US US12/580,641 patent/US20100036132A1/en not_active Abandoned
- 2009-11-25 US US12/625,973 patent/US20100152460A1/en not_active Abandoned
2010
- 2010-11-18 IL IL209402A patent/IL209402A/en active IP Right Grant
2013
- 2013-07-16 JP JP2013147688A patent/JP5802242B2/ja not_active Expired - Fee Related
2015
- 2015-02-19 CY CY20151100172T patent/CY1116104T1/el unknown
- 2015-04-14 HR HRP20150417TT patent/HRP20150417T1/hr unknown

Also Published As

Publication number	Publication date
EP1863764A1 (en)	2007-12-12
JP2008533141A (ja)	2008-08-21
WO2006099060A2 (en)	2006-09-21
MX2007011412A (es)	2008-02-22
JP5384933B2 (ja)	2014-01-08
NO20075268L (no)	2007-12-10
AU2006223482A1 (en)	2006-09-21
CR9438A (es)	2008-09-09
ZA200708809B (en)	2009-03-25
IL209402A (en)	2015-06-30
BRPI0607793A2 (pt)	2009-06-13
IL185974A0 (en)	2008-01-06
KR101280929B1 (ko)	2013-07-01
ES2535048T3 (es)	2015-05-04
IL185972A0 (en)	2008-01-06
EA200701978A1 (ru)	2008-04-28
MY145333A (en)	2012-01-31
JP2013234192A (ja)	2013-11-21
US7629488B2 (en)	2009-12-08
CN101175725B (zh)	2011-02-02
DK1858850T3 (en)	2015-02-09
AR054745A1 (es)	2007-07-11
EA200701979A1 (ru)	2008-04-28
AU2006223394A1 (en)	2006-09-21
RS53873B1 (en)	2015-08-31
CA2601481A1 (en)	2006-09-21
HUE024912T2 (en)	2016-02-29
EA015512B1 (ru)	2011-08-30
TWI414518B (zh)	2013-11-11
WO2006099060A3 (en)	2006-11-02
BRPI0607792A2 (pt)	2009-06-13
EA014366B1 (ru)	2010-10-29
EP1858850A2 (en)	2007-11-28
US20100152460A1 (en)	2010-06-17
ME02110B (me)	2015-10-20
TWI500595B (zh)	2015-09-21
JP5802242B2 (ja)	2015-10-28
ZA200708810B (en)	2009-01-28
KR20070112255A (ko)	2007-11-22
CY1116104T1 (el)	2017-02-08
MX2007011409A (es)	2008-02-22
NO20075269L (no)	2007-12-10
HRP20150417T1 (en)	2015-09-25
CA2601674A1 (en)	2006-09-21
KR20070116067A (ko)	2007-12-06
US20100036132A1 (en)	2010-02-11
AU2006223394B2 (en)	2012-10-18
US20060211863A1 (en)	2006-09-21
CN101175725A (zh)	2008-05-07
IL185972A (en)	2013-07-31
NZ590570A (en)	2012-06-29
EP1858850B1 (en)	2015-01-21
PL1858850T3 (pl)	2015-06-30
WO2006098982A1 (en)	2006-09-21
CN101175726A (zh)	2008-05-07
SI1858850T1 (sl)	2015-04-30
JP2008533143A (ja)	2008-08-21
TW200700388A (en)	2007-01-01
TW201302676A (zh)	2013-01-16
IL209402A0 (en)	2011-01-31
CA2601481C (en)	2013-11-12
US20060211861A1 (en)	2006-09-21
NO340604B1 (no)	2017-05-15
AR053170A1 (es)	2007-04-25
PT1858850E (pt)	2015-02-24
NI200700237A (es)	2008-06-25

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