TW200608968A - Tetrasubstituted imidazole derivatives as cannabinoid cb1 receptor modulators with a high cb1/cb2 receptor subtype selectivity - Google Patents
Tetrasubstituted imidazole derivatives as cannabinoid cb1 receptor modulators with a high cb1/cb2 receptor subtype selectivityInfo
- Publication number
- TW200608968A TW200608968A TW094116864A TW94116864A TW200608968A TW 200608968 A TW200608968 A TW 200608968A TW 094116864 A TW094116864 A TW 094116864A TW 94116864 A TW94116864 A TW 94116864A TW 200608968 A TW200608968 A TW 200608968A
- Authority
- TW
- Taiwan
- Prior art keywords
- receptor
- art
- relates
- imidazole derivatives
- disclosed
- Prior art date
Links
- 229940079865 intestinal antiinfectives imidazole derivative Drugs 0.000 title abstract 3
- 229930003827 cannabinoid Natural products 0.000 title abstract 2
- 239000003557 cannabinoid Substances 0.000 title abstract 2
- 150000002460 imidazoles Chemical class 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 5
- 102000009132 CB1 Cannabinoid Receptor Human genes 0.000 abstract 3
- 108010073366 CB1 Cannabinoid Receptor Proteins 0.000 abstract 3
- 239000003814 drug Substances 0.000 abstract 3
- 238000004519 manufacturing process Methods 0.000 abstract 3
- 230000009286 beneficial effect Effects 0.000 abstract 2
- 201000010099 disease Diseases 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- -1 1,2,4,5-tetrasubstituted imidazole Chemical class 0.000 abstract 1
- 102000009135 CB2 Cannabinoid Receptor Human genes 0.000 abstract 1
- 108010073376 CB2 Cannabinoid Receptor Proteins 0.000 abstract 1
- 208000012902 Nervous system disease Diseases 0.000 abstract 1
- 208000025966 Neurological disease Diseases 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 208000020016 psychiatric disease Diseases 0.000 abstract 1
- 239000002464 receptor antagonist Substances 0.000 abstract 1
- 229940044551 receptor antagonist Drugs 0.000 abstract 1
- 239000002469 receptor inverse agonist Substances 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
The present invention relates to 1,2,4,5-tetrasubstituted imidazole derivatives as selective cannabinoid CB1 receptor modulators, in particular CB1 receptor antagonists or inverse agonists having a high CB1/CB2 receptor subtype selectivity, to methods for the preparation of these compounds and to novel intermediates useful for the synthesis of said imidazole derivatives. The invention also relates to the use of a compound disclosed herein for the manufacture of a medicament giving a beneficial effect. A beneficial effect is disclosed herein or apparent to a person skilled in the art from the specification and general knowledge in the art. The invention also relates to the use of a compound of the invention for the manufacture of a medicament for treating or preventing a disease or condition. More particularly, the invention relates to a new use for the treatment of a disease or condition disclosed herein or apparent to a person skilled in the art from the specification and general knowledge in the art. In embodiments of the invention specific compounds disclosed herein are used for the manufacture of a medicament useful in the treatment of psychiatric and neurological disorders. The compounds have the general formula (1), , wherein the symbols have the meanings given in the specification.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP04076619 | 2004-05-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TW200608968A true TW200608968A (en) | 2006-03-16 |
Family
ID=34928258
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW094116864A TW200608968A (en) | 2004-05-28 | 2005-05-24 | Tetrasubstituted imidazole derivatives as cannabinoid cb1 receptor modulators with a high cb1/cb2 receptor subtype selectivity |
Country Status (5)
| Country | Link |
|---|---|
| CN (1) | CN1956965B (en) |
| AR (1) | AR052763A1 (en) |
| SA (1) | SA05260148B1 (en) |
| TW (1) | TW200608968A (en) |
| UA (1) | UA85239C2 (en) |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI231757B (en) * | 2001-09-21 | 2005-05-01 | Solvay Pharm Bv | 1H-Imidazole derivatives having CB1 agonistic, CB1 partial agonistic or CB1-antagonistic activity |
-
2005
- 2005-05-24 AR ARP050102138 patent/AR052763A1/en not_active Application Discontinuation
- 2005-05-24 TW TW094116864A patent/TW200608968A/en unknown
- 2005-05-25 SA SA05260148A patent/SA05260148B1/en unknown
- 2005-05-26 UA UAA200613783A patent/UA85239C2/en unknown
- 2005-05-26 CN CN2005800162950A patent/CN1956965B/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CN1956965A (en) | 2007-05-02 |
| UA85239C2 (en) | 2009-01-12 |
| CN1956965B (en) | 2011-03-23 |
| AR052763A1 (en) | 2007-04-04 |
| SA05260148B1 (en) | 2008-11-15 |
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