TW200534982A - Molds for producing contact lenses - Google Patents

Abstract

This invention describes molds made from alicyclic co-polymers that are useful in the production of contact lenses and methods for their use.

Description

200534982 A7

‘It ’s like making objects with hidden lenses. Objects and how to use them. Relevant Application Cases 5 The monthly application case is a partial continuation of US patent application serial number 10 / 395,755 'and the latter is a partial continuation of US patent application serial number 2,373. ^ BACKGROUND OF THE INVENTION Eyeglasses have been used commercially to improve vision 10f since the 195Gs. Contact lenses were originally made of hard materials. Although these contact lenses are still used 'J, but because of their poor comfort when first worn Compared with _ Oxygen / Hometown | ±, the relative car weight is low, so it is not suitable for all patients. In this field, we have developed soft contact lenses based on hydrogels, which are now very popular. These lenses have high oxygen permeability and are more comfortable to wear than contact lenses made of hard materials. Different from the production of hard lens lathes and hard-coated lathes plus the printing staff of the Consumer Cooperatives of the Intellectual Property Bureau of the Ministry of Economic Affairs, which has extended quality records, it often relies on two-component moldings to produce lenses. The pattern of the desired completed lens, these examples of moldings and methods can be found in the US patent

4,565,348, 4,640,489, 4,495,313, JP 08025378, and JP 20 0726644, the entire contents of which are incorporated herein by reference. These two-part moldings include a male member whose convex surface corresponds to the back curve of the 7G industrial film, and a female member whose concave surface corresponds to the front curve of the finished lens. When using these moldings to prepare lenses , Put the uncured lens formula between the concave and convex surfaces of the half-mold of the molding, and then the description of the invention (2) for curing. The cured lens and molding are then treated with a liquid medium to release the cured lens from the surface of the molding. Although this is a simple method, there are several requirements that must be met before a usable lens can be made: first, the material from which the molding is made must be chemically compatible with the uncured lens formula, and second, The material of the molding must be able to withstand the curing conditions and be compatible with these conditions, for example, the lens can be cured by heat and / or light. If the curing of the lens transmits light to the uncured polymer, it is important that the lens molding allows transmission of light of an appropriate wavelength. Third, the molding material must not stick to the cured lens to the extent that it prevents the release of the cured lens. Usually lens 10 is prepared in a manufacturing environment. The important thing is that the lens can be removably adhered to the same lens molding, and the separation can be repeated in a predictable manner during separation. The appropriate materials have always been the subject of concern for those who make soft contact lenses. Other materials that have been used to make two-part lens moldings, such as poly [5 propylene, polyethylene, polyethylene, polymethyl methacrylate, and a process that contains an alicyclic component in the main chain Modified polyolefin. Although these materials are useful for discovering different lens formulations, especially silicone hydrogel lens formulations, other useful molding materials are still needed. In addition, new developments in this field have led to contact lenses made from hydrogels and silicone hydrogels coated with polymers to improve lens comfort. Lens coatings often use polymers to mature lenses. For processing. Recently, the manufacture of polymer-coated lenses involves coating the surface of a two-part molded article with a polymer, adding an uncured formulation to the coated lens molding, curing the lens, and then curing the lens. The lens is released from the molded product, A7 B7 200534982 V. Description of the invention (3) The polymer coated on the surface of the cured lens is initially attached to the mold surface. This method is described in more detail in 2. 01 * August 8 'National Patent Application No. _21,192, whose name is "Method of Correcting Objects", so the entire text is incorporated herein for reference. When using this method to coat lenses, the choice of molding material is even more severe than for those who manufacture uncoated lenses. i Therefore, for the manufacture of lens moldings, which can be used to make many different types of soft lenses, there is still a lack of demand, and the following inventions meet this demand. 10 15 Printed by the Consumer Cooperative of the Intellectual Property Bureau of the Ministry of Economic Affairs 20 Detailed description of the invention The present invention includes a molded article for making lenses, which includes: mainly including or containing a lipid-copolymer, wherein the lipid-copolymer Including: mainly containing or containing at least two alicyclic monomers with different chemical structures. As used in this specification, the term "lens" refers to any eye device that is placed in or on the eye 'and these devices can provide optical bridges or make-up. Lens-The term includes but is not limited to: soft contact lenses, intraocular lenses, cover lenses, eye inlays, and optical inlays. The invented preferred mirror M is a Weapon body or a hydrogel-like contact lens, which includes, but is not affected by, the hydrogel and fluorine hydrogel. The formula of soft fe-shaped glasses is disclosed in: U.S. Patent 5,71,302, WO9421698, EP 4G6161, [p2G () () () 169 () 5, U.S. Patent 5,998,498, U.S. Patent Application Serial No. 9 / 957,299, dated September 20, 2008, Shen Yan, US Patent Application No. 09 / 532,943, US Patent-5-200534982 A7 B7 V. Description of Invention (4) 10 15 Employees ’Cooperatives, Intellectual Property Bureau, Ministry of Economic Affairs Printed 20,087,4, 5, US Patent 5,760,100, US Patent 5,776,999, US Patent 5,789,461, US Patent 5,849,811, and US Patent 5,965,631. Other polymers that can be used to generate soft contact lenses are disclosed in U.S. Patents 6,419,858, 6,308,314, and 6,416,690, and the entire contents of the aforementioned references are incorporated herein by reference. Particularly preferred lenses in the invention are: etafilcon A, genfilcon A, lenefilcon A, polymacon, acquafilcon A, balafilcon A, lotrafilcon A, galyfilcon A, and senofilcon A. The preparation of the silicone hydrogel is as follows: U.S. Patent No. 5,998,498, U.S. Patent Application No. 09 / 532,943, which is a continuation of the part of U.S. Patent Application No. 09 / 532,943 filed on August 30, 2000. Patent No. 09 / 957,299 was filed on September 20, 2001. The preparation of soft contact lenses is as follows: US Patent Application No. 60 / 318,536, titled "Biomedical Device Containing Internal Wetting Agent", applied on September 10, 2001, non-temporary with the same name Supplement 'was filed on September 6, 2002, U.S. Patent 6,087,415, U.S. Patent 5,760,100, U.S. Patent 5,776,999, U.S. Patent 5,789,461, U.S. Patent 5,849,8n, and U.S. Patent 5,965,63. The entire text of these patents (and applications) and all other patents disclosed in this application are incorporated herein by reference. As used in this specification, the term alicyclic monomer, means a polymerizable compound having at least one saturated carbocyclic ring, which can be replaced by one or more members of the following groups : Hydrogen, CM0 alkynyl, halogen, hydrogen, CM0 alkynyl, C | -10 alkynyl, ammonium, amino, iminium, silane, and optionally CI1G alkyl, which substitutes -6-6 A7 B7 2Θ0534982 V. Description of the invention (It is a member selected from one or more of the following groups, including: halogen, meridian, cM0, carbamoyl, cMGoxy, cyano, Amido, imino, and crushed. Examples of alicyclic monomers include, but are not limited to: polymerizable cyclobutane, cyclopentane'cyclohexane, cycloheptane, cyclooctane Alkane, bicyclobutane, dicyclopentane, bicyclohexane, bicycloheptane, bicyclooctane, and original borneol. The difficult person secrets at least two photomonomers, and then undergoes a hydrogenation reaction after ring-opening substitution. Because Copolymers are very expensive, so it is difficult to replace a single one 10 times. When using a typical number, it can be used more than— The present invention is preferably a molded lens was prepared comprising a saturated aliphatic carbon rings which were not limited to the following structure-limb of which particularly preferred examples include, but 15

r1 R4;

Printed by a member of the Qiqilang Intellectual Property Bureau and Consumer Cooperatives 20

among them

Each independently selected from: and R1

The composition of one or more of the following groups: 200534982 A7 B7 V. Description of the invention (6) members, including ... hydrogen, Ci_iO alkyl, halogen, meridian, Cmoxy alkoxyl, CM〇 alkoxy , Cyano, amido, amido, silyl, and substituted CMO alkyl, the substituents of which are selected from one or more of the following groups of members, including: halo, hydroxyl, Cl_1G alkoxy Carbonyl, CMG alkoxy, cyano, amido, amido, and silyl. In addition, two or more R atoms, together, form an unsaturated bond, a carbocyclic ring, a carbocyclic ring containing one or more unsaturated bonds, or an aromatic ring. Preferably, R1-6 is selected from the group consisting of: CM alkyl, and substituted alkyl, wherein the substituent is selected from the group consisting of: halogen, hydroxyl, Cl-ι. Alkoxycarbonyl, c, -10 alkoxy, cyano, reeling, fluorenimine, and weyl. H alicyclic copolymers include at least two v substances containing two or, 15 20

Binding • 8- 200534982 A7 B7 10 15 Printed by Jiuzou Intellectual Property Bureau Employee Consumer Cooperatives 20 V. Description of Invention (7)

The saturated carbocyclic ring of the cyclic monomer has the formula r1r & common structure, and 1 ^ -1 ^ 4 is a Cwo alkyl group. The typical surface energy of a cyclic copolymer is between 30 and 45 dyne / cm at 25 ° C. The best alicyclic copolymer contains two different cyclic monomers and is sold by Zeon Chemicals L.P. under the trade name ZEONOR. ZE〇NO〇R comes in several different grades with glass

The cancer metastasis temperature is 105-160 ° C. The best ZEONOR is ZEONOR 1060R. According to the manufacturer, Zeon Chemicals LP ·, its melt flow rate ("MFR") ranges from lh0 g / 10 minutes to g minutes ( According to JISK 6719 test (230 × :)), the specific gravity (water = 1) ¾ 1 · 〇1, and the glass transition temperature is 105. 〇. As used in this specification, the term "molded article" refers to a rigid object that can be used to produce lenses from uncured formulations. The preferred molded article is the two-part molded article described above. The front curve or the back curve of the plastic is made of the alicyclic copolymer according to the present invention, and other curves are made of polypropylene. Examples of polypropylene include, but are not limited by, the metal double ring Polypropylene catalyzed by pentylene complex, and nucleated and purified, for example, but not limited to it: Achieve 1615 and ATOFINA EOD 00-11 from Exxon. The best method is to use injection molding using provincial technology, but other techniques can also be used to make the molded product, such as lathe machining, diamond turning, or laser cutting. -9- A7 B7 200534982 V. Description of the invention (8 ) Typically, lenses are produced on at least one surface of each of the two parts of the molding, however, if necessary, the lens-surface can be produced from the molding and the other surface can be produced using lathe machining or other methods. 10 15 Ministry of Economic Affairs Printed by the Bureau ’s Consumer Cooperatives20 In addition to the alicyclic copolymer, the moldings according to the present invention may contain additives that can separate the surface produced by the lens, or reduce the properties of the curved lens on the surface of the molding, or For both, for example: before curing the polymer to form a molding, add additives such as: stearic acid metal or ammonium salt, ammonium wax, polyethylene or polypropylene wax, organic phosphate ester, glyceride , Or alcohol esters are added to alicyclic copolymers. Examples of such additives include, but are not limited to: Dow Siloxane MB50-321 (a kind of silicone dispersant), Nurcrel 535 & 932 ( Ethylene-Methacrylic Copolymer Resin, 'Book No. 25505 · 53 · 6), Erucamide (Fatty Acid Ammonium, Registration No. 12 · 84-5), Oleamide (Fatty Acid Ammonium, Registration No. 301-02-0) Mica (Registration No. 12001-26-2), Atmer 163 (Fat Alkyl Diethanolamine, Registration No. 107043-84-5), Pluronic (Polyoxypropylene-Polyoxyethylene Ethylene Block Copolymer, Registration No. 106392-12-5), Tetronic (amine alkoxide, 110617-70-4), Flura (registration number 7781-49-4), hard Acid acid, stearic acid, Super-floss anti-blocking agent (slip / anti-blocking agent, registration number 61790-53-2), Zeosphere anti-blocking agent (slip / anti-blocking agent), Ampacet 40604 (Fatty acid ammonium), Kemamide (fatty acid ammonium), Licowax fatty acid ammonium, Hypermer B246SF, XNAP, polyethylene glycol monolaurate (antistatic), epoxidized soybean oil, talc (magnesium silicate hydrate) , Calcium carbonate, camellic acid, pentaerythritol tetrastearate, succinic acid, epolene E43-Wax, methylcellulose-10- 200534982 B7 V. Description of the invention (9) ^-Element, cocamide (anti-adhesive agent, registration No. 61789-19-3), polyethylene sigma-pylon (molecular weight 360,000), and the additives disclosed in US Pat. No. 5,690,865, which are incorporated herein by reference in their entirety. Preferred additives are polyvinylpyrrolidone, zinc stearate, and 5 glyceryl monostearate. The weight percentages of the additives, based on the total weight of the polymer, are from about 0.05 to about 10.0 weight percent. With about 0.05 to about 30 Mati father and nephew, about 2.0 weight percent is the best. 10 15 In addition to the additives, the separation of the lens generating surface can be achieved by applying an interfacial active agent to the surface of the lens #. Examples of suitable surfactants include: Tween surfactants, especially as described in the United States Tween 80, which is 5,837,314, is hereby incorporated by reference in its entirety. Examples of his surfactants are disclosed in U.S. Patent 5,264.161, which is hereby incorporated by reference in its entirety. In addition, in addition to the alicyclic copolymer, according to the present invention, the material can also contain other polymers, such as: polypropylene, polyethylene, polystyrene, poly? Acrylic acid " 'and modified s polyolefins containing alicyclic components in the main chain, for example: you can use alicyclic cyclic copolyesters and poly (jectives) (metal bicyclic pentylene Ethylene complex catalyzed and nucleated using ΑΤΟΠΝΑ EOD 0 (M1), the ratio of its alicyclic copolymer to polypropylene weight percentage range from about 99: 1 to about 2_. One or both of the moulded half parts, preferably this pusher is used for the "transcription and frontal rotation of fat-containing silks." = In addition to include-prostitutes for lenses, including Mainly including or Shi W- 种 未 鼠 之 镜 #Cai scattered on the surface of difficult objects 20 200534982 _______ B7 V. Description of the invention (10) Mainly includes or includes: an alicyclic copolymer, wherein the alicyclic copolymer Include ... Mainly include or include: at least two alicyclic monomers having different chemical structures, and 2) curing the lens formula under appropriate conditions, and the terms lens, alicyclic monomer, and moldings have Its foregoing meaning and a better range than 5. As used in this specification, the term "unripe," Refers to a lens formulation prior to final cure to generate a lens, the lens prescription of the physical state, some was aged monomer mixture comprising only once. Other lens formulations include monomers, partially cured monomers, macromolecules, and other components. Ten examples of such partially cured formulations are disclosed in: US Patents 6,419,858, 6,308,314, and 6,416,690. These formulations can be used in the present invention And other recipes. :: Used in this manual, matured under suitable conditions, is intended to use the conventional method of using any mature lens formula, such as making reading, heat, and appropriate catalysts to manufacture Cured lenses, 15 steam examples of such curing conditions can be found in the soft lens formulation references listed in this specification. In addition, the present invention also includes a lens, the manufacturing method of which includes: 1) Dispersing an uncured lens formula on the surface of a molded object, which includes or includes:-an alicyclic copolymer, The alicyclic copolymer includes: mainly including or including: at least two alicyclic monomers having different chemical structures, and 2) curing the lens formula under suitable conditions, lenses, alicyclic monomers, and immature Terms such as chemical and molding have their aforementioned meanings and preferred ranges. In addition, the present invention also includes a molding, including: mainly including or -12-200534982 a7 ______B7 _V. Description of the invention (7 ~~~~~-Including:-a kind of alicyclic copolymer 'and at least-a kind of lens The surface of the fatty filament includes: mainly including or enclosing at least two alicyclic monomers having different chemical structures, and the surface where the at least one kind of lens is formed, including: mainly including or 5 including: ― High-molecular-weight coating composition with the number of coating effects. The terms lens, alicyclic monomer, uncured, and molding have their aforementioned meanings and preferred ranges. "^, Used in this specification, "The surface of the lens" refers to the surface used to mold the lens. This surface has a surface modification of optical quality. The tone 10 means that it is sufficiently smooth, so the lens produces a surface that touches the molded object. The surface of the lens produced by the polymerization reaction is optically acceptable. In addition, the surface has a geometric shape that must impart the desired optical properties to the surface of the lens, including, but not limited to: spherical, non-spherical, and cylindrical Shape 2 Correction of numbers, corrections of wavefront light aberrations, corrections of comeal patterns, the same as 15, and combinations thereof. The term "high molecular weight" means a sufficiently high average molecular weight ("Mw ,,") to prevent The coating is dissolved in the lens formulation or molding material. For the purpose of the invention, it is preferred to measure the amount of 20T by gel permeation chromatography ("Gpc,"), using a light scattering detector And a high-sensitivity refractive index detector 0, such as model PL-RI, available from Polymer Labs. GPC is performed using a 5 micron phenol gel linear column, which is installed with the same composition Guard column, 0.5% by weight bromide in dimethylformaniline as eluent, the flow rate is ml per minute, and its injection volume is from about 10 to about 20 microliters. The exact molecular weight is based on -13- A7 B7 200534982 '\ _ 5. Description of the invention (I2 The coating and the monomer mixture used are determined. In a preferred embodiment, the molecular weight of the coating is greater than about 300 kD. It can be used in the present invention, coating composition ", package A wide variety of conventional monomers and polymers, preferably used: poly (vinyl alcohol), polyethylene oxide, poly (2-hydroxyethyl methacrylate), poly (methyl methacrylate), Poly (acrylic acid), poly (methacrylic acid), poly (maleic acid), poly (itaconic acid), poly (acrylamide), poly (fluorenylacrylamide), poly (dimethylpropane) Amine), poly (fluorenyl acrylate), polystyrene sulfonic acid, polysulfonate polymer, poly (vinyl pyrrolidone), carboxymethylated polymer, such as: carboxymethyl 10 15 Intellectual Property Bureau, Ministry of Economic Affairs Employee Consumer Cooperatives printed 20-based cellulose, polysaccharides, glucosaminoglycans, polylactic acid, polyethanol, etc., or random copolymers, analogues, and cord mixtures. The preferred ones are poly (methacrylic acid-ethylacetate), poly (acrylic acid), poly (acrylic acid), poly (fluorenyl acrylic acid), poly (methramine, Poly (acrylic acid amine), the best is poly (ethyl methacrylate). "In addition to the two-high-1 cyclic compound, the coating composition may include- Higher than about boots) solvents. Suitable: = point solvents include 'but not limited by it: acetone, aerosol, and alcohols, such as · methanol, ethanol, isopropanol, radibutanol, and similar Useful high-boiling solvents include, but are not affected by, Gonggan's limitations: methyl ... ethyl-, octapropylpropyl, ethylene and (poly) ethylene glycol, propylene glycol, n- Methyltransferanone's dimethylformamide, tetrahydrogeranol ^ ^ ^ ^ ^ Butanol, 1-pentanol, 1-known, 1-octanol, 3-methyl isopentyl alcohol, Dioxol-3-octanol, 3-methylaminobutanol, 1,2- and M-butanediol, ticks, -hex-ferment, water, and the like-14-200534982 A7 B7 Description of the invention (typically, when coating between 15 and 45 ° C, low to high boiling point solvents The ratio is about 10:90 to 90:10. When the coating composition is applied using spin coating (discussed below), the coating composition contains one or both of a low boiling point solvent and a high boiling point solvent. 10 15 Ministry of Economic Affairs Printed by the Intellectual Property Bureau's Consumer Cooperatives20 In addition, the coating composition may include at least one surfactant, suitable surfactants include, but are not limited to: anionic surfactants, such as carboxylates, sulfonates , Sulfate, phosphoric acid and polyphosphate, cationic surfactants, such as: long-chain amines and their salts, diamines, and polyamines, and their salts, quaternary amine salts, amine oxides, non-ionic interfaces Active agents, such as: polyoxyalkylated alkylphenols, alkylphenol ethoxylates, polyoxyalkylated linear alcohols, polyethoxylated polyoxypropanols, polyethoxylated Polydifluorene-based sintered copolymer, fluorinated chain red oxide copolymer, and long-chain carboxylic acid esters, zwitterionic surfactants, such as pH-sensitive and pH-insensitive ionic surfactants, and Analogs, and combinations thereof. Of the fine surfactants The specific surface and quantity depend on the other components of the coating composition and the surface of the mold. Typically, = the total weight of the coating composition is used as a basis, and the weight is higher than the scale to about i% by weight, and The coating composition is less than or equal to about 5% by weight. The coating composition can be applied to the surface of the molding by any suitable method, including, but not limited to: compression molding, painting, spray coating, spray coating Ink printing, air spraying, spraying, dip coating, spin coating, and the like, and recording combination are better to use spin coating, and more preferably, i is used to generate i First, cover the surface or make it sticky. It can be dried by any suitable method, preferably at a temperature as high as about -15-200534982

、 Explanation of the invention (The glass transition temperature ("Tg") of the material, under the air or in the direct space; with === degrees' up to about the glass transition of the molding material2, and under the heart, Equilibrium. In the process of vacuum «, the comparison is to make the enemy more difficult to stop the moldings from being contaminated. 10 For spin-coating towels, the better is: the button composition has a more molded surface The surface has a low surface tension. The better is: the coating composition has a surface that is more difficult than the secret area. The amount is low, less than 3, due to the surface tension of the lambda knife, which is applied to the coating. Measured at the temperature of the object. The best one is the surface energy of the surface of the object, which is lower than the surface energy of the object, the difference is greater than 8 dyne / cm, and the surface tension is better. _In the surface method | Use spin coating to deposit-dry thickness of about 5 to about 7G nanometers | on the silk surface of the molding, if the surface tension of the coating and the surface energy of the molding, Measured at the temperature at which the coating is applied, when the difference is greater than about 8 dyne / cm, suitable rotation conditions are: at least about 6,000 but not high At about 8.000 RPM 'use at least about 2 but no more than about 20 microliters of coating composition' and rotate for at least about 3 seconds. If the difference in surface tension is less than about 8 dyne / cm 'molded Rotate to at least about 3,000 but not more than about 20. Order 5.000 RPM 'use at least about 2 but not more than about 10 microliters of coating composition' and then mold to rotate to at least about 7,000 but not high At about 10,000 RPM, at least about 3 seconds before stopping. Any excess coating that has accumulated on the edges of the molding must be removed. The removal can be performed by any conventional method, including ： But not subject to the situation -16- 200534982 μ — ----- Β7 V. Description of the invention (15) Limitation · Wipe off excess material, use vacuum, solvent, cleaning or pressurized air nozzle to remove excess material, It is better to use an air nozzle to remove the excess. It is important to start the rotation before opening the nozzle, and more preferably, the pressure of the air nozzle is equal to or higher than about 3 psi. 5 'Effective coating amount "- The word means the thickness and roughness of the coating composition on the lens generating surface, which is hidden from hydration. Spectacles are preferred: the peak-to-peak surface roughness of the hydrated lens is preferably less than about 500 nanometers, so effective coating means that the amount of coating composition is sufficient to provide a surface for the lens The dry film thickness of the coating composition can be used to obtain hydrated pieces with acceptable surface roughness for contact lens 10. It is preferred that the surface chain of the peak to peak of the hydrated lens is less than about 500 nm, and more The preferred one is: the amount of the coating composition used is sufficient to produce a dry film having a thickness of at least about 5 nm, but not higher than about 70 nm, and at least about 5 nm, but not high It is preferably about 50 nm, more preferably at least about 20 nm, but not more than about 40 nm, and the most effective is that the effective coating amount can cover the entire or mainly the entire lens generation surface. The consumer cooperation of the Jiuzou Intellectual Property Bureau. Printing can add coating additives to the high molecular weight coating composition according to the present invention. The coating additives can include, but are not limited by, colorants, pigments, And antimicrobial composition, 20 cases of antimicrobial composition that can be used in this way are disclosed in the following U.S. patents and applications, which are hereby incorporated by reference in their entirety. U.S. Patents 6,218,492, 6,248,811, 6,160,056 With US Patent Application No. 10 / 028,400, filed on December 20, 2001, named Antimicrobial Contact Lenses and Manufacturing Method thereof, and 10 / 〇29,526, filed on December 21, 2001, named Anti-Microbeam -17- A7 B7 200534982 V. Description of the invention (16 biological contact lenses and methods of using the same. The present invention also includes a method for making coated lenses, the spoon mainly includes or includes: (1) in the lens molding At least one lens-forming surface is coated with a high molecular weight coating composition in an effective coating amount, wherein the dream film molding comprises an alicyclic copolymer, and at least one The raw surface of the lens, wherein the alicyclic copolymer includes, mainly includes or includes: at least two alicyclic monomers of different chemical structures, 10 15 printed by the Consumer Cooperatives of the Intellectual Property Bureau of the Ministry of Economic Affairs 20 (2) a kind of immature The chemical lens formula is dispersed on the at least one lens generating surface, and (3) curing the lens formula and the coating composition is performed under conditions suitable for generating a coated lens, using a residence time of less than 5 minutes. , Alicyclic monomer, uncured, molding, high molecular weight, coating composition, and effective coating amount all have their aforementioned meanings and preferred ranges. ^ In order to illustrate the present invention, it includes the following Examples, but these examples are not limited to the present invention, and their significance is only to suggest a method for applying the present invention. Those skilled in the manufacturing of lenses and other expertise can find other methods of applying the present invention. However, these methods should be considered as belonging to Within the scope of the present invention, 0 Examples are used in the examples, and the following abbreviations are used: -18- 200534982 B7 V. Description of the invention (17) BC back curve blue -HEM A The product obtained by subjecting one gaseous substance of reactive blue # 4 to a base-facilitated substitution reaction by using hydroxyethyl acrylate, 5 CIP pre-cure CGI 1850 1-hydroxycyclohexylphenyl ketone and bis (2,6 -Dimethoxyfluorenyl 2monyl) 1: 1 (by weight) blend of 2,4,4-dimethylfluorenyl scale emulsion CGI 819 bis (2,4,6-trimethylbenzylhydrazone) Group) Phenylphosphine oxide 10 D3 03,7 · dimethyl-3-octanol Darocur 1173 DMA N, N-dimethylpropanamide, an ultraviolet photoinitiator of Cibaite Chemical Company. V: FC Frontal curve ATOFINA EOD 00-11 — a metal dicyclopentadiene complex with isotactic 15 polypropylene with a melt flow rate of 14-18 g / 10 minutes, ASTM D1238 HEMA 2-hydroxyethyl methacrylate IPA isopropyl Alcohol macromolecule 2 The reaction product described in the example below: U.S. Patent Application No. 10 / 028,400, filed on December 20, 2001, named: Antimicrobial Contact Lenses and Its Manufacturing Method Polyacrylyloxypropyl 19-200534982 A7 B7 V. Description of the invention (ι〇

m-PDMS-OH

Norbloc PVP Poly-Hema SIGMA 10 15

TEGDMA TrEGDMA TBACB THF TMI TRIS Mono- (3-methacryloxy-2-hydroxypropyloxy) propyl end group Mono-dimethyl polydimethylsiloxane (MW 1100 ) 2- (2'-hydroxy-5-methacryloxyethylphenyl) -2H-benzyl. Poly (N-vinylpyrrolidone) polyhydroxyethyl methacrylate, with a molecular weight greater than 1MM Dalton 2-propanoic acid, 2-fluorenyl-, 2-hydroxy-3- [3- [1,3, 3,3-tetramethyl-1-[(trimethylsilyl) oxy] disilaxyl] propoxy] propyl ester difluorenyl acrylate tetraethylene glycol diethyl methacrylate Glycol Ester-tetrabutylammonium tetrahydrofuran 3-isopropenyl-α, α-difluorenylbenzyl isocyanate 3-methacryloxypropyltri- (trimethylsilyloxy) Shixuan acne and ziqilang cooperate on behalf of the Hui property and the shellfish consumer; print 20 Example 1 Use a cycloaliphatic copolymer to prepare a molded product. Place pellets of the cycloaliphatic copolymer ZEONOR® 1060R into 90. (: About one to four (1_4) hours in a desiccant dryer, followed by heating and removing the material through an injection molding machine, using the general description in the injection molding manual-20- 200534982 ^ ____ B7 V. Description of the invention (19) Technology 'Edited by Dominick and Donald Rosato, 1986 by Nan

Published by Nostmnd Reinhold. Approximately three (3) pounds of material were removed and molded within 10 to 15 minutes to obtain a front curve and a back curve of a lens with a magnification of -100 D. A lens mold 5 which is normally usable can be recovered and used to make lenses in accordance with the procedure of Example 2. Example 2 Further details of the precise mixing procedure for the preparation of a silicone hydrogel lens using the formulations listed in Table A are disclosed in US Patent Application No. 09 /, filed on September 20, 2001. 957,299.

Table A Weight percentage-^ Molecule 2 ~ ^ 17.98 TRIS 14.00 DMA 26.00 MPDMS 28.00 TEGDMA 1.00 HEMA 5.00 PVP 5.00 NORBLOC 2.00 Summer HEMA ~ 0.02 CGI 1850 1.00 The other parts of the formula are additives and diluents, monomers for diluents The ratio was 100: 20, the diluent was 3,7-dimethyloctanol, and 1 ° / 0 acetic acid in the final mixture was used to stabilize the monomer. -21- 200534982 A7 B7 V. Description of the invention (2010 15 The front and back curve moldings prepared according to the method of Example 1 will be coated with a high molecular weight poly HEMA coating. By spin coating at 8000 rpm For 8 seconds, apply approximately 6 microliters of 1.3% by weight polyHEMA in a 70:30 ethanol: ethyl lactate solution to the surface (concave surface) of the front curve molding. During the last 2 seconds of the rotation cycle, An air jet was applied to the edge of the rotating part to remove excess coating. By spin-coating at 6000 rpm for 2 seconds, and then at 8000 rpm for 6 seconds, approximately 8.5 microliters of 1.1% were aggregated HEMA at 70:30 ethanol: ethyl lactate solution, applied to the surface of the back curve molding (convex). During the last 2 seconds of the rotation cycle, an air jet is applied to the edge of the rotating part to remove excess coating The lens is made by adding the aforementioned lens formulation to the lens mold to 'close the part, pre-cure at 45 ° C under visible light for 45 seconds, and then at 70 ° C under visible light for 7 minutes. For all Case, after adding the lens monomer dose to the molding 30 Within seconds, pre-maturation begins. The clinical test found that the lens has the same wettability on the eye as ACUVUE etafilcon A lens, or the tearing apart time, and the resistance to deposition, showing that the application of the coating to the lens can achieve physiological Compatible lenses. Binding printed by employees of the Intellectual Property Bureau of the Ministry of Suiji 20 printed by the cooperative. Example 3 Preparation of polypropylene lens moldings. The front and back curves of lens moldings were prepared using the method of Example 1 and polypropylene was used. Diluted (EOD 00-11 manufactured by Atofina) to replace the alicyclic copolymer in Example 1. -22- A7 B7 200534982 V. Description of the invention (21) Example 4 Preparation of lens using the molded article of Example 3 The formulation and method of Example 2, but the molding of Example 1 is replaced by the molding of Example 3. The finished lens is used-a visual inspection device to check for defects on the coating. The defect is that no coating is applied on the surface of the finished lens Area of the object, the percentage of defects is calculated and recorded in Table B shown below. This example shows that a molded product made from an alicyclic copolymer can be used to make coated lenses, which has a large Reduced coating defects.

10 Example printed by the Consumer Property Agency of the Intellectual Property Bureau of the Ministry of Economic Affairs 5 20 Lenses made by Koto Molding on the front curve and the back curve Using front curve and back curve moldings produced using the methods 1 and 3 'Lens was prepared according to the method of Example 2. As shown in Table c, some moldings were used to make some of them, and their face-to-face ratio and blur were reduced. The measurement of the value shown in the figure is to place the job system in place. -23- 22 200534982 V. Description of the invention 埤 In the salt water of the transparent chamber above the black background, the fiber optic lamp is perpendicular to the mirror chamber 66. The angle is illuminated from below, and the image of the lens is taken from above using a video camera. After subtracting the scattered light image of the background, the following method was used to analyze it: The 10 mm area in the center of the lens was integrated, and then it was combined with a CSI thin lens (commercially available lens, with a -ι · 0.00 refractive index) Compared with Wesley J_n, 33 East Tower A, Des Planes, Illinois), the blur value of the latter is arbitrarily set to 100, and the blur value of the lens is set to this data. This data shows: When the front curve and the back curve are molded When produced from an alicyclic copolymer, a minimum number of defects occur. 10

ZEONOR

ZEONOR

PP

PP

Table C Coating defect ratio 0J% Ύ% Order 60 30 1.4% 8.5% d 31.2 Consumption by employees of the Intellectual Property Bureau of the Ministry of Economic Affairs, printed by Jiangxi 20 Example 6 Preparation of a lens molding using an alicyclic copolymer The alicyclic polymerization The pellets of Zeonex® 480R were placed in a 100 t: dry block of about four (4) hours. Attempts were made to use the method of Example i to produce a molded object, but the use of this material could not produce a shaped lens molding. Only the droop of the cured material was obtained without forming a recess for the lens molding. Increasing the temperature of the molding machine (to the greatest extent possible under safety), the temperature of the material cannot correct this problem, and it is impossible to produce a useful molding. This example shows -24- V. The description of the invention (23) shows the difference between the successful preparation of alicyclic _molding_ and _view polymerization to produce molded articles. Example 7 5 Preparation of a Push-Molded Product A quantity of polypropylene (octabutane 0-8) 〇011, 50%) and ze 00n060R (50%) in a mixing drum Blending was carried out for 15 minutes, and the mixture was then subjected to a plastic or granulation procedure to produce a homogeneous material. The blended material is placed in an injection molding machine, extruded into male and female half parts of the lens 10 mold, and then cured, and the cured mold is placed under a nitrogen atmosphere for 30 minutes before use . Example 8 Preparation of Silane Hydrogel Lens B-15 The reaction components listed in Table D and the diluent (D30) were mixed at about 2rc with stirring or rolling for at least about 3 hours until all All wounds have been bathed, and the reaction components are recorded as weight percentages of all reaction components. The diluent is the weight percentage of the final reaction mixture. The reaction mixture was placed in the lens molding of Example 7 and irradiated with a Phillips TL20W / 03T fluorescent bulb at 45 ° C and nitrogen 20 gas. The ripening conditions in a nitrogen operation box were: 2 mW / c2 for about 6.5 minutes, followed by 2.5 mWw / c2 for about 12 minutes, with an oxygen content below 15% oxygen. By manually opening the mold and evaluating the lens, determine whether the cured lens still needs to reside in the front curve or back curve mold. Table E lists the molding of each lens 200534982 A7 B7 V. The percentage of Zeonor and polypropylene (pp) in the half part of the invention description (24), and after the two are separated, the lens model B still resides in the front curve or Number of lenses in the back curve.

Table D Lens type BCDEFGHIJK Composition SIGMA 28 30 28.6 28 31 32 29 39.4 20 68 PVP (K90) 7 10 7.1 7 7 7 6 6 6.7 3 7 DMA 24 17 24.5 23.5 20 20 24 16.4 37 22 mPDMS 31 32 0 31 31 34 31 29.8 15 0 TRIS 0 0 〇 0 0 0 0 0 15 0 HEMA 6 6 6.1 6 6.5 3 5.5 2.9 8 0 Norbloc 2 2 0 2.0 2 2 2 1.9 0 CGI 1850 0.48 1 1.02 1 1 1 1 1 1 0 'TEGDMA 1.5 2 1.02 1.5 1.5 1 1.5 1.9 0 2 TrEGDMA 0 0 0 0 0 0 0 0 1 0 Blue HEMA 0.02 0 0 0 0 0 0 0 0 0 mPDMS-OH 0 0 31.6 0 0 0 0 0 0 0 Darocur 1173 0 0 0 0 0 0 0 0 0 1 D30% 23 26 17 23 23 29 32 28 17 27 -26- A7 200534982 V. Description of the invention (25)

Table E Back curve Front curve Lens in front curve% Total number of tests 5% pp 95% Zeonor 100% Zeonor 29 24 25% pp 75% Zeonor 100% Zeonor 71 24 35% pp 65% Zeonor 88 24 35% pp 65% Zeonor 100% Zeonor 91 32 40% pp 60% Zeonor 100% Zeonor 97 32 40% pp 60% Zeonor 100% Zeonor 100 24 45% pp 55% Zeonor 100% Zeonor 100 32 50% pp 50% Zeonor 100% Zeonor 100 32 75% pp 25% Zeonor 100% Zeonor 100 32 This example shows that as the amount of polypropylene in the blend increases, the number of lenses that adhere to the front curve increases. Printed by the Employees' Cooperatives of the Intellectual Property Bureau of the Ministry of Economic Affairs -27- This paper size applies to China National Standard (CNS) A4 (210x297 mm)

Claims (1)

A8 B8 C8 D8 10 200534982 / 、, Qingqing Patent Scope L A molded article for making lenses, which includes an alicyclic copolymer 'wherein the alicyclic copolymer includes at least two lipids having different chemical structures Cyclic monomer. 2. The molded article according to item 1 of the scope of patent application, wherein the alicyclic monomer includes polymerizable cyclobutane, cyclopentane, cyclohexane, cycloheptane, cyclooctane, bicyclobutane, dicyclopentane Alkane, bicyclohexane, bicycloheptane, bicyclooctane, or orthobornane. 3 · According to the patent scope The molded article of item 2, comprising two alicyclic monomers, wherein the alicyclic monomers include a saturated carbocyclic ring. 4. The molded article according to the scope of the patent application, wherein the alicyclic monomer is selected from the group including: " Printed by employees of the Intellectual Property Bureau of the Ministry of Economic Affairs on consumer cooperation 20 R5 R6, and Wherein RN6 is each independently selected from the members of one or more of the following groups, including: hydrogen, CMO alkyl, functional element, hydroxyl, Cm. Alkoxy -28-This paper size applies to China National Standard (CNS) A4 (210x297 mm) A8 B8 C8 D8 The scope of application for patent M is 200534982, which is a carbon group, CMG alkoxy group, cyano group, amidino group, amidino group, silyl group, and a substituted CMG alkyl group. The substituents are selected from the group consisting of inclusion groups, hydroxyl groups, CM. Alkoxy, CMO alkoxy, cyano, amido, amido, and silane. 5. The molded article according to the scope of item i of Shenyan's patent, wherein the alicyclic monomer is selected from the group consisting of: 10 15 Printed by the Employees' Cooperatives of the Intellectual Property Bureau of the Ministry of Economic Affairs 20 • Together with κ, one or more R16 can form an unsaturated bond, a charcoal ring, a carbon ring containing one or more unsaturated bonds, or an aromatic ring. Since the material of item 1 in 1ϋΐ, in which ㈣-shaped monomers -29 This paper is applicable to China National Standards (CNS) A4 regulations ^ ⑷ 297 public comment 200534982 A8 B8 C8 D8 Wherein R1 · 6 are each independently selected from members of one or more of the following groups: 'including: hydrogen, CMO alkyl, halogen, hydroxyl, Cm alkylalkynyl, CMG alkoxy, cyano, amido , Fluorenimine, silane, and substituted CMG alkyl, the substituents of which are selected from one or more of the members of the following groups, including: _ prime, hydroxyl, cMG alkoxy carbon, Cno alkane Oxygen, cyano, amido, amido, and silyl. 7. The molded article according to item 1 of the scope of the patent application, wherein R1-6 is a CMo alkyl group or a substituted C ^ o alkyl group, wherein the substituent group is selected from the group consisting of: · Nansu, hydroxyl, cMG alkyl Oxycarbonyl, Cmq alkoxy, cyano 'acid amine, ammonium, and stilbene. 8. According to the scope of the patent application, the molded product of item 帛 丨, in which the alicyclic monomer is the philanthropy of the Ministry of Economic Affairs 20 Where R1 4 is independently selected from the CM0 pit group. 9, According to the molded article of the patent claim 1, the secret size of the paper is suitable for the paper size 30 200534982 6. The scope of the patent application 2 has a dazzling body flow rate (tender) of about 11 g / 10 Minutes to degrees g / 10 minutes, specific gravity is ⑽, and glass transition temperature 10. The molding according to item i of the patent application scope, wherein the molding further comprises an additive. U% of zinc stearate. 12: Please: The molded article of the profit range of item 10, which is added with glyceryl monostearate at a rate of .100. 13 .: Two: The molding of the two items 'wherein the front curve shape · A brother / 10 minutes to about ΐ8.0 · Gong Xiang / Yi Yizhong' specific gravity is 1. 〇1, and the glassy state ^^ 14 · According to The scope of patent application! 2 degrees. Property :: Molded product, in which the front-curve 11 n / day city copolymer has a impurity rate of about •: g / 10 min to about 18.0 g / 10 min. »The molding around item 1, where the back curve = axon-shaped silk H tree body, minutes to about 丨,. G /...^ According to Shin. The molded article of the J range of the patent, including the front curve I_____-31-Life Ruler—Zhongliang A8 B8 C8 D8 200534982 6. The scope of the patent application includes an alicyclic copolymer with a melt flow rate of Η · 〇g / 10 minutes to about 18.0g / 10 minutes, specific gravity is 1.01 'and glass transition temperature is 105t, and the back curve includes polypropylene, and an alicyclic copolymer, which With a melt flow of 14, the distribution rate of the melt flow rate is = 12 g and 17.6 g, the specific gravity is 101, and the glass transition temperature is ι05. . . 10 15 Printed by the Consumer Cooperatives of the Intellectual Property Bureau of the Ministry of Economic Affairs 20 The molded object according to item 1 of the declared patent scope, wherein the back curve includes an alicyclic copolymer with a melt flow rate of about η · g / ίο minutes to about 18 g / 10 minutes, specific gravity is ι · 〇ι, and glass transition temperature is 1050c, and the front curve includes polypropylene, and an alicyclic copolymer, which The rate of body flow 1 is about 11.0 g / 10 minutes to about 18 g / 10 min. The specific gravity is i.01, and the glass transition temperature is 105. (:. 18. The molded article according to item 16 of the scope of Zhonglili, wherein the ratio of the alicyclic copolymer to the polypropylene is about 5:95 to about% 5. 19 ^ f Plastic, in which the ratio of the alicyclic copolymer to the polypropylene is about 20:80 to about 80:20. 20. A method of making a lens, including an uncured lens formulation dispersed On the surface of the molded article, a cyclic copolymer is included, wherein the alicyclic copolymer is wrapped into an alicyclic monomer having a shirt structure, and) the lens formula is cured under appropriate conditions. The method of “I root” please turn to item 2G, which includes two alicyclics. The paper size is applicable to China-32-200534982 A8 B8 C8 D8 6. Patent application scope monomers, in which the alicyclic monomers include a saturated Carbocycle 22. The method according to item 20 of the scope of patent application, one of which is selected from the group, including: Printed by the Intellectual Property Bureau of the Ministry of Economic Affairs 20 10 15 Includes: halogen, hydroxy, CuiG alkoxycarbonyl, Ci ig alkoxy, cyano, Si amine, imino, and Shikiba. 23. According to the method of applying patent scope 帛 2 ", wherein the alicyclic single system is selected from the group, including: -33-A8 B8 C8 D8 200534982 VI. Patent scope 10 15 Dan γ—Yu Yuxi 1 solid kappa to generate an unsaturated bond, carbocyclic ring, carbocyclic ring containing one or more unsaturated bonds, or aromatic ring. 24. The method according to item 20 of the scope of patent application, wherein the alicyclic single system is selected from the group, including: ′, printed by the Consumer Cooperative of the Intellectual Property Bureau of the Ministry of Economic Affairs 20 R6 u η ... Yi ~ Xinkou 丨 From the evening to the members of the following groups, including: hydrogen, cMG alkyl, dentin, hydroxyl, CmO alkoxy Ik group Cm0 oxygen group, cyano 'amino group , Imino group, Shixiyan group, and substituted CMG alkyl group, the substituents of which are selected from one or more -34-This paper size applies to Chinese National Standard (CNS) A4 specifications (21 × 297 mm) ) 6. The scope of the patent application is for members of the following groups, including: halogen, hydroxy, Ci · fluorenyloxy, hexyl, cMG alkoxy, cyano, amido, amido, and silyl. / 、 25. The method according to item 20 of the scope of patent application, wherein r1 · 6 is a, alkane 5 10 15 20 group, or substituted CMO alkyl group, wherein the substituent group is selected from the group consisting of: 1 prime, Group, Cl_1G alkyloxycarbonyl group, Cmg alkoxy group, nitrogen group, fluorenylamino group, fluorenimine group, and silyl group. 26. The method according to claim 20 of the patent scope, wherein the alicyclic monosystem is selected from the group consisting of: Wherein R14 is each independently selected from c1 · 10 alkyl. 27. The method according to item 2 () of the patent application, wherein the surface of the mold includes a front curve and a back curve, and the method further includes the following steps: 3) the front curve of the lens molding The object is separated from the back curve of the lens mold, wherein the cured lens is removably attached to the front curve. 2M The method according to item 20 of the patent application, wherein the front curve comprises an alicyclic copolymer having a melt flow rate (Mfr) of about 11.0 g A0 minutes to about 18 g g / 10 Minutes, specific gravity of 丨 · 01, glass transition temperature of 105 ° C, and back curve -35, 200534982 10 15 At the beginning of the game, the crowd was dilute. 29. The method according to item 26 of the scope of patent application, further comprising: a kind of alicyclic copolymer, which has: medium: surface curve 11.0 g / 10 minutes to about 丨 80 g / 1/10 capture rate is about I .01 'with transition temperature of 1G5 ° C, with 2' specific gravity including polypropylene, and-ring-like = curve-like movement rate is about 11.0 g / 1 (eight) with melt flow clock , The specific gravity is 101, the plate glass is about 18.0 g / 10 minutes, and the glass transition temperature is 105 ° C. 30. The method according to item 28 of the scope of patent application, wherein the ratio of the alicyclic copolymer to the polypropylene in the back curve is from about 20:80 to about 80:20. 31. According to the scope of patent application The method of item 28, wherein the ratio of the alicyclic copolymer to the polypropylene is about 55, such as in the back-line free material. 32. A molded article comprising an alicyclic copolymer and at least one surface forming a lens Ordered by the Consumer Finance Cooperative of the Smart Finance Bureau of the Ministry of Economic Affairs, where the alicyclic copolymer includes at least two alicyclic monomers with different chemical structures, and at least one of the f forms the surface of the lens, including a coating effect Within a few miles the molecular weight coating composition. 20 M. A molded article according to item 32 of the scope of patent application, which includes two alicyclic monomers, wherein the alicyclic monomer includes a saturated carbocyclic ring. 34. The molded article according to item 32 of the scope of patent application, in which the alicyclic single system is selected from the group, including -36-This paper is subject to the Chinese National Standard (CNS) A4 specification (2 丨 〇χ 297 Mm) IIIII 200534982 8 8 8 8 AB CD 6. Scope of patent application 10 15 Printed members of the Consumer Cooperatives of the Intellectual Property Bureau of the Ministry of Economic Affairs include: hydrogen, Ci_io, alkyl, halogen, mesogen, Cl-loxocarbonyl, CMG alkoxy, cyano, amido, and imine Group, silyl group, and substituted Cmo alkyl group, the substituents of which are selected from the group, including: functional group, meridian group, CMG alkoxy group, CMG alkoxy group, cyano group, amine group, amidine Amine group, and Shi Xiyan group. 35. The molding according to item 32 of the patent application, wherein the alicyclic monomer is selected from the group consisting of: 20 -37- This paper size applies to China National Standard (CNS) A4 (210x297 mm) 200534982 6. Scope of patent application A8 B8 C8 D8 ; Together with R1 R4, one or more of R1-6 can be combined to generate one or more unsaturated bond rings, private soils, 3M. According to the patent, the scope of the patent No. 32 10 is selected from the group, including: T Months are in the shape of a flat body 15 Printed by the Consumer Cooperative of the Intellectual Property Bureau of the Ministry of Economic Affairs 20 base. 37. The molding according to item 32 of the scope of patent application, where Ri-6 is Ci ^ -38-This paper size is applicable @National Standard (CNS) A4 specification (21Gx297 public reply) 200534982 A8 B8 C8 D8 VI. Application Patent scope =, or substituted Ci.ig alkyl group, where the substituent is selected from the group of cylinders =. 'Prime, meridian, cM. Benzyloxy, C |, Benzyloxy, Atomyl, Amido, Amido, and Silyl. 38. The second, the range of moldings, selected from the group consisting of: lithography 10 15 Printed by the Employees ’Cooperatives of the Intellectual Property Bureau of the Ministry of Economic Affairs 20 where R1 · 4 is independently selected from an additive of cM0 Baku. 40. According to the scope of the patent application No. 39 x 呗, the additive is zinc stearate with a weight percentage of about 0% by weight. 41. According to the scope of application for patent No. 39 9 π. ^, A plastic branch, wherein the additive is about 2.0% by weight and 1% zinc stearate. 42. The stretched article according to item 3 ^ of the scope of the patent application, wherein the coating composition includes a coating additive. 43. According to the scope of the patent application, the 39th antimicrobial composition. The plastic plate 'where the additive is a 44. a lens' is made by a method ^ ^ It includes: 1) an uncured = scattered on the surface of the molding, which includes-a kind of alicyclic 4 'Where the alicyclic copolymer includes at least two alicyclic monomers with different chemical structures, and 2) ripen the -39 under suitable conditions-This paper is in accordance with China National Standard (CNS) A4 specifications ( 21〇X 297 mm) A8 B8 C8 D8 200534982 6. Patent scope of patent application. 45. The lens according to item 44 of the patent application scope, which includes two alicyclic monomers, wherein the alicyclic monomer includes a saturated carbocyclic ring. 46. According to the scope of patent application 苐 44, the alicyclic single system is selected from the group, including: 10 15 Members of Book 20, including: hydrogen, Ci-io, alkyl, halogen, meridian, cM0oxy, hexyl, Cmg, oxo, cyano, amido, amido, sulfonyl, And substituted CMG alkyl groups, the substituents of which are selected from the group consisting of: self-priming, light-based, Cmg-amino, CM-alkyl, cyano, amido, amido, and Silyl. 47. The lens according to item 44 of the scope of the patent application, wherein the alicyclic single system is selected from the group, including: -40-This paper size applies the Chinese National Standard (CNS) A4 regulation ^ 7 ^ _x 297 public iT AC 200534982 bs C8 D8 6. Scope of patent application 10 15 Printed by 20 employees of the Intellectual Property Bureau of the Ministry of Economic Affairs, Consumer Cooperatives, including: hydrogen, CmOxyl, halogen, meridian, CMOxyloxycarbonyl, CMGalkoxy, cyano, amido, and fluorene Amine, silyl, and substituted Cm0 alkyl, the substituents of which are selected from one or more of the following groups, including: halogen, hydroxyl, CM0 alkoxycarbonyl, Cuo alkyloxy, cyano , Amidino, amidino, and > arsenyl. $ 48 · The lens according to item 44 of the scope of patent application, in which CM0 alkyl, or substituted CM0 alkyl, wherein the substituent is selected from the group consisting of: halogen, mesogen, CmO, oxoyl, CM0 Hydroxy, cyano, amido, amido, and silyl. 49. The lens according to item 44 of the patent application, wherein the alicyclic single system is selected from the group consisting of: R1 and R4 are each independently selected from cM0 alkyl 50. According to the 44th scope of the patent application, the lens is not matured -41-This paper size applies the Chinese National Standard (CNS) A4 regulations ^^ 1〇χ297 ) '---------- ^ 200534982' C8-: ------ _D8__ VI. Shen Qing patent scope formula includes Shixi Oxygen Burning Hydrogel Formula. 51. The lens according to item 44 of the scope of patent application, wherein the uncured lens formula includes a hydrogel formula. 52. The lens according to item 44 of the scope of patent application, wherein the uncured lens 5 formula includes: acquafilcon A, balafilcon A, lotrafilcon A and other formulas. 53. The lens according to item 44 of the scope of patent application, wherein the uncured lens formula includes: etafilcon A, genfilcon A, lenefilcon A, polymacon, acquafilcon A, balafilcon A, galyfilcon A, or senofilcon A, or lotrafilcon A. 54. The lens according to item 44 of the scope of patent application, wherein the uncured lens formula includes: acquafilcon A, balafilcon A, lotrafilcon A, galyfilcon A, or senofilcon A. 55. The lens according to item 44 of the patent application, wherein the surface of the molded object includes a front curve and a back curve. Printed by the Consumer Cooperative of the Intellectual Property Bureau of the Ministry of Economic Affairs 56. The lens according to item 55 of the patent application, wherein the front curve includes an alicyclic copolymer with a melt flow rate (MFR) of about 11.0 g / 10 Minutes to about 18.0 g / 10 minutes, a specific gravity of 1.01, a glass transition temperature of 105 ° C, and a back curve 20 including polypropylene. 57. The lens according to claim 55, wherein the front curve comprises an alicyclic copolymer having a melt flow rate of about U.0 g / 10 minutes to about 18.0 g / 10 minutes, and a specific gravity 1 · 〇1, glass transition temperature is 105 ° C, and the curve on the back is -42-This paper size applies the Chinese National Standard (CNS) A4 specification (2ωχ297 mm) B8 C8 D8 200534982 VI. Patent application Range propylene, with an alicyclic copolymer, which has a melt flow rate of about U.0 g / 10 minutes to about 18 g / 10 minutes, a specific gravity of ㈤, and a glass transition temperature of 105 . 〇. 58. According to the application, the lens around item 55, in which the ratio of 1¾ and the shape of the co-binder to the polypropylene in the back curve is about 2:80 to about 80:20 〇59. According to the patent application The lens of Item 55, wherein the ratio of the alicyclic copolymer to the polypropylene in the curved surface is approximately 55:45. 60. A method for manufacturing coated lenses, comprising: 101520 printed on at least one lens forming surface of a lens molding by a consumer cooperative of the Intellectual Property Bureau of the Ministry of Economic Affairs, using a high molecular weight coating composition with an effective coating amount And the lens core plastic includes an alicyclic silk, and & a lens generating surface, where the alicyclic copolymer includes at least two alicyclic monomers of different f Body, (2) disperse a kind of uncured lens # formula on the lens-generating surface, and (3) cure the lens square _ coating the product, under conditions suitable for generating coated lenses Make the dwell time of 5 minutes. The method according to the scope of patent application of item 60 includes two alicyclic monomers, wherein the alicyclic monomer includes a saturated ring. 62. The method of root = _1__6G is called ring-shaped single system. The group is selected from the group consisting of: -43-200534982 S D8 6. Scope of patent application 10 15 Printed by the Employees' Cooperatives of the Intellectual Property Bureau of the Ministry of Economic Affairs 20 where RN6 are each independently selected from one or more of the following groups, including: hydrogen, CM0 alkyl, halogen, hydroxyl, Cbo alkoxyweiyl, Ci_i〇 Burntoxy, aryl, amine, imimine, stilbene, and substituted CMG alkyl, the substituents of which are selected from the group, including: halo, hydroxyl, CMG alkoxycarbonyl, Cmo alkoxy, cyano, amino, cyano, and cyano. 63. The method of claim 60, wherein the alicyclic monosystem is selected from the group consisting of: -44- This paper size applies to the Chinese National Standard (CNS) A4 specification (210x297 mm) 200534982 A8 B8 C8 D8 round 10 6. Application for patents where R1 6 are each independently selected from one or more of the following groups, including: hydrogen , CM〇-Hexyl, haloyl, meridian, cM0 alkoxycarbonyl, CMG alkoxy, cyano, amido, amido, silyl, and substituted CMG alkyl, the substituents are A member selected from one or more of the following groups, including: hydroxy, hydroxy, Ci ig alkoxyglycol, CM alkoxy, cyano, amido, amido, and silyl . 64. The method according to item 60 of the patent application, wherein R1 · 6 is a CM0 alkyl group or a substituted Cmo alkyl group, wherein the substituent is selected from the group consisting of: a halogen group, a CMo alkyl group, C 丨-丨 〇 alkoxy group, cyano group, amino group, amido group, and silyl group. 65. The method according to item 60 of the scope of patent application, wherein the alicyclic single system is selected from the group consisting of: binding 15 Printed by the Consumer Cooperatives of the Intellectual Property Bureau of the Ministry of Economic Affairs 20 where R1 · 4 are each independently selected from C1-10. 66. The method according to item 60 of the patent application scope, wherein the high molecular weight coating composition includes: poly (vinyl alcohol), polyethylene oxide, poly (2-hydroxyethyl methacrylate), poly (methyl Acrylic acid ester), poly (acrylic acid), poly (methacrylic acid), poly (maleic acid), poly (itaconic acid), poly (acrylamide), poly (methacrylamide), poly (di Methacrylamide), poly (glyceryl methacrylate), polystyrene sulfonic acid, polysulfonic acid ester polymer, 45-This paper size applies to China National Standard (CNS) A4 (210x297 mm) A8 B8 C8 D8 20Θ534982 6. Scope of patent application Poly (vinylpyrrolidone), carboxymethylated polymers, such as: methylmethyl cellulose, polysaccharides, glucosaminoglycans, polylactic acid, polyglycolic acid, Block or random copolymers, and mixtures thereof. 67. The method according to item 60 of the application, wherein the high molecular weight coating 5 composition includes: poly (2-hydroxyethyl methacrylate), poly (vinyl pyrrolidone), poly (acrylic acid), poly (曱Acrylic acid), poly (fluorenyl) acrylamide, or poly (acrylamide), and mixtures thereof. 68. The method according to claim 60, wherein the high molecular weight coating composition comprises poly (2-hydroxyethyl methacrylate). 10 69. The method according to item 60 of the application for a patent, wherein the high molecular weight coating composition includes: poly (vinyl alcohol), polyethylene oxide, poly (2-hydroxyethyl methacrylate), poly (methyl Acrylic Acrylate>: poly (acrylic acid), poly (acrylic acid), poly (maleic acid), poly (acrylic acid), poly (acrylic acid), poly (acrylic acid), poly (acrylic acid) Dimethacrylamide), poly (曱 15-based glyceryl acrylate), polystyrenesulfonic acid, polysulfonate polymer, poly (vinylpyrrolidone), carboxymethylated polymer, such as Cellulose, polysaccharides, glucosaminoglycans, polylactic acid, polyglycolic acid, block or random copolymers of the foregoing, and mixtures thereof. Printed by the Consumer Cooperative of the Intellectual Property Bureau of the Ministry of Economic Affairs 70. According to the patent application The method of the scope item 60, wherein the surface of the molded article includes a front curve and a back curve. 71. The method according to the scope of the patent application, item 70, wherein the front curve includes an alicyclic copolymer, and The back curve includes polypropylene. 72. The method according to item 70 of the scope of patent application, wherein the front curve object includes an alicyclic copolymer, and the back curve object includes an alicyclic -46-This paper is scaled to China (iii ^ S) A4 specifications-( 21〇χTear H 200534982 Ss C8 D8 —--_--_ —-1 6. Copolymer and polypropylene in the scope of patent application 73. The method according to item 70 in the scope of patent application, wherein the front curve includes a lipid A cyclic copolymer having a melt flow rate (MFR) of about 11.0 g / 10 minutes to about 18.0 g / 10 minutes, a specific gravity 5 of 1.01, a glass transition temperature of 105 ° C, and a curve on the back including 74. The method according to item 70 of the patent application, wherein the front curve comprises an alicyclic copolymer having a melt flow rate of about 11.0 g / 10 minutes to about 18.0 g / 10 minutes, and a specific gravity. Is 101.01, with a glass transition temperature of 105 ° C, and the back curve includes polypropylene, and an alicyclic copolymer, which has a melt flow rate of about 11.0 g / 10 minutes to about 18.0 g / 10 minutes, specific gravity is 1.01, and glass transition temperature is 105 ° c. 75. The method according to item 74 of the patent application scope, wherein the ratio of the alicyclic copolymer to the polypropylene in the curve 15 on the back side is About 20:80 to about 80:20. 76. The method according to item 74 of the scope of patent application, wherein the ratio of alicyclic copolymer to polypropylene in the back curve is about 55:45. Intellectual Property of the Ministry of Economic Affairs The paper size printed by the Bureau ’s Consumer Cooperatives applies the Chinese National Standard (CNS) A4 specification (210 X 297 mm) 200534982 (1): ~ 本 _ 寒 寒 定 表 _ 参 # 第 璧 蓝 兴 无 '(二) 、 A brief description of the component representative symbols in this representative map: None Page 2-1 200534982 Description of invention patent: (This manual is in the format, order and bold type, please do not change it arbitrarily. ※ Please do not write in the part of note) f ※ Application number: q ※ Application date: c I. Name of the invention ... (Chinese / English) MOLDS FOR PRODUCING CONTACT LENSES (2) Applicant: (1 person in total) Name or name: (Chinese / English) Johnson & Johnson VISION CARE , INC. Representative ·· (Chinese / English) King Ross / GIANNESCHI, LOIS A. Residence or Business Office Address: (Chinese / English) 7500 Centurion Parkway, Suite, 7500 Centurion Parkway, Jackway, Florida, USA 100, Jacksonville, Florida 32256, USA Nationality: (Chinese / English) United States / USA III. Inventor: (10 in total) Name: (Chinese / English) 1. Du Da Shi / DUBEY, DHARMESH K. 2. Du Na / TURNER, DAVID C. 3. Ronnie / ROONEY, THOMAS R. 4. Ma Kaiwen / MCCABE, KEVIN P · 5. Cooper / COPPER, LENORAL. 6. Scott / ANSELL, SCOTTF. 7. Tomma S / MATI ACIO, THOMAS A. 8. Houlicha / FOUGERE, RICHARD J. 1 · Λ Patent Application \ Invention Application MVC92435-Invention Application (Amendment) .doc 200534982 9 · Aibo Rui / ABRAMS, RICHARD W. 10. Ge Duoming / GOURD, DOMINIC Nationality: (Chinese / English) 1. India / INDIA 2. US / USA 3. US / USA 4. US / USA 5. US / USA 6. US / USA 7. For the United States / USA 8. For the United States / USA 9. For the United States / USA 10. For the United States / USA 4. Declaration: □ Claims Article 22, Paragraph 2 of the Patent Law □ Paragraph 1 or □ Paragraph 2 The stipulated facts are dated as follows: 0The patent has been applied to the following countries (regions) before the application: [format please follow: note of the receiving country (region), application date, application case number order] □ You have claimed the first international priority of Article 27 of the Patent Law: U does not claim the first international priority of Article 27 of the Patent Law: 1. United States; August 16, 2002; 10 / 222,373 2. United States; March 24, 2003; 10 / 395,755 Article 29, Item 1, Domestic Priority: [For the format, please refer to the application note and the application note serial number notes] □ Claim Article 30 Biological Materials of the Patent Law: J: \ Patent Application \ Invention Application \ JVC92435-Invention Application (Amendment) .doc 200534982 9 · Aibo Rui / ABRAMS, RICHARD W. 10. Ge Duoming / GOURD, DOMINIC Nationality: (Chinese / English) 1. India / INDIA 2. USA / USA 3. US / USA 4. US / USA 5. US / USA 6. US / USA 7. US / USA 8. US / USA 9. US / USA 10. US / USA 4. Items to be declared: □ Clause Article 22, Item 2 of the Patent Law □ First Or the fact that the provisions of paragraph □, said that the fact that the occurrence period: year, month, said. 0The patent has been applied to the following countries (regions) before the application: [format please follow: note of the receiving country (region), application date, application case number order] □ You have claimed the first international priority of Article 27 of the Patent Law: U does not claim the first international priority of Article 27 of the Patent Law: 1. United States; August 16, 2002; 10 / 222,373 2. United States; March 24, 2003; 10 / 395,755 Article 29, Item 1, Domestic Priority: [For the format, please refer to the application note and the application note serial number notes] □ Claim Article 30 Biological Materials of the Patent Law: J: \ Patent Application \ Invention Application \ JVC92435-Invention Application (Amendment) .doc 200534982 □ Those who need to deposit biological materials: Domestic biological materials [Please follow the format of the deposit institution, date, and number notes] Foreign biological materials [Please refer to the deposit country, institution, format, Notes on the date and number sequence] [□ Those who do not need to deposit biological materials: Those who have ordinary knowledge in the technical field are easy to obtain, do not need to deposit. 1-2 J: \ Patent Application \ Invention Application \ JVC92435-Invention Application (Amendment) .doc A5 B5 200534982 Chinese Abstract of the Invention (Name of the Invention: Molded Article for Making Contact Lenses This invention is described from the alicyclic The molded article of the copolymer is used in the manufacture of contact lenses, and its use method. Abstract of the Invention (Name of the Invention: Molds for producing contact lenses I ♦ η This invention describes molds made from alicyclic co-polymers that are useful in the Production of contact lenses and methods for their use. The Consumer Cooperative of the Intellectual Property Bureau of the Ministry of Economic Affairs printed a moderate rule sheet of paper. A4 centimeters 7 9 2 200534982 Designated representative map: (1) The designated representative map in this case is: ( ) Figure. None (II) Simple description of the component symbols of this representative figure: None 2-1 J: \ Patent Application \ Invention Application \ JVC92435-Invention Application (Amendment), doc 200534982 If this case has a chemical formula, please disclose The chemical formula that best shows the characteristics of the invention: None 2-2 J: \ patent application \ invention application \ JVC92435- invention application ( N) .doc