TW200500367A - Triazole compounds useful in therapy - Google Patents
Triazole compounds useful in therapyInfo
- Publication number
- TW200500367A TW200500367A TW093103978A TW93103978A TW200500367A TW 200500367 A TW200500367 A TW 200500367A TW 093103978 A TW093103978 A TW 093103978A TW 93103978 A TW93103978 A TW 93103978A TW 200500367 A TW200500367 A TW 200500367A
- Authority
- TW
- Taiwan
- Prior art keywords
- alkyl
- independently represent
- optionally substituted
- ring
- halogen
- Prior art date
Links
- -1 Triazole compounds Chemical class 0.000 title 1
- 238000002560 therapeutic procedure Methods 0.000 title 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 7
- 125000000623 heterocyclic group Chemical group 0.000 abstract 4
- 229910052736 halogen Inorganic materials 0.000 abstract 3
- 150000002367 halogens Chemical class 0.000 abstract 3
- 125000004429 atom Chemical group 0.000 abstract 2
- 229910052757 nitrogen Inorganic materials 0.000 abstract 2
- 229920006395 saturated elastomer Polymers 0.000 abstract 2
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 abstract 1
- 206010013935 Dysmenorrhoea Diseases 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Vascular Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Urology & Nephrology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0303852.8A GB0303852D0 (en) | 2003-02-19 | 2003-02-19 | Triazole compounds useful in therapy |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TW200500367A true TW200500367A (en) | 2005-01-01 |
Family
ID=9953327
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW093103978A TW200500367A (en) | 2003-02-19 | 2004-02-18 | Triazole compounds useful in therapy |
Country Status (11)
| Country | Link |
|---|---|
| CN (1) | CN1751047A (es) |
| AR (1) | AR043210A1 (es) |
| CL (1) | CL2004000293A1 (es) |
| GB (1) | GB0303852D0 (es) |
| GT (1) | GT200400020A (es) |
| NL (1) | NL1025527C2 (es) |
| PA (1) | PA8596101A1 (es) |
| PE (1) | PE20050222A1 (es) |
| TW (1) | TW200500367A (es) |
| UY (1) | UY28201A1 (es) |
| WO (1) | WO2004074291A1 (es) |
Families Citing this family (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0325021D0 (en) * | 2003-10-27 | 2003-12-03 | Pfizer Ltd | Therapeutic combinations |
| US7745630B2 (en) | 2003-12-22 | 2010-06-29 | Justin Stephen Bryans | Triazolyl piperidine arginine vasopressin receptor modulators |
| DE102004001871A1 (de) * | 2004-01-14 | 2005-09-01 | Bayer Healthcare Ag | Tricyclische Benzazepin-Derivate und ihre Verwendung |
| EP1784408A1 (en) | 2004-08-25 | 2007-05-16 | Pfizer Limited | Triazolobenzodiazepines and their use as vasopressin antagonists |
| US20080188478A1 (en) * | 2005-04-26 | 2008-08-07 | Pfizer Inc. | Compounds Useful In Therapy |
| KR101348499B1 (ko) | 2008-11-13 | 2014-01-06 | 에프. 호프만-라 로슈 아게 | 스피로-5,6-다이하이드로-4ｈ-2,3,5,10ｂ-테트라아자-벤조〔ｅ〕아줄렌 |
| PE20110590A1 (es) * | 2008-11-18 | 2011-08-31 | Hoffmann La Roche | Alquilciclohexileteres de dihidrotetraazabenzoazulenos |
| DK2370441T3 (da) | 2008-11-28 | 2013-10-21 | Hoffmann La Roche | Arylcyclohexylethere af dihydrotetraazabenzoazulener til anvendelse som vasopressin v1a-receptorantagonister |
| EP2414361A1 (en) | 2009-03-31 | 2012-02-08 | ArQule, Inc. | Substituted heterocyclic compounds |
| US8765728B2 (en) * | 2009-11-16 | 2014-07-01 | Mellitech | [1,5]-diazocin derivatives |
| US8420633B2 (en) | 2010-03-31 | 2013-04-16 | Hoffmann-La Roche Inc. | Aryl-cyclohexyl-tetraazabenzo[e]azulenes |
| US8461151B2 (en) * | 2010-04-13 | 2013-06-11 | Hoffmann-La Roche Inc. | Aryl-/heteroaryl-cyclohexenyl-tetraazabenzo[e]azulenes |
| US8492376B2 (en) | 2010-04-21 | 2013-07-23 | Hoffmann-La Roche Inc. | Heteroaryl-cyclohexyl-tetraazabenzo[e]azulenes |
| US8481528B2 (en) * | 2010-04-26 | 2013-07-09 | Hoffmann-La Roche Inc. | Heterobiaryl-cyclohexyl-tetraazabenzo[e]azulenes |
| US8513238B2 (en) * | 2010-05-10 | 2013-08-20 | Hoffmann-La Roche Inc. | Heteroaryl-cyclohexyl-tetraazabenzo[E]azulenes |
| US9006450B2 (en) * | 2010-07-01 | 2015-04-14 | Boehringer Ingelheim International Gmbh | Compounds, pharmaceutical compositions and uses thereof |
| EP2625170A1 (en) | 2010-10-07 | 2013-08-14 | Takeda Pharmaceutical Company Limited | 1,4-oxazepane derivatives |
| RU2011122942A (ru) | 2011-06-08 | 2012-12-20 | Общество С Ограниченной Ответственностью "Асинэкс Медхим" | Новые ингибиторы киназ |
| US8828989B2 (en) * | 2011-09-26 | 2014-09-09 | Hoffmann-La Roche Inc. | Oxy-cyclohexyl-4H,6H-5-oxa-2,3,10b-triaza-benzo[E]azulenes as V1A antagonists |
| JP6062948B2 (ja) * | 2011-10-05 | 2017-01-18 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | Ｖ１ａアンタゴニストとしてのシクロヘキシル−４Ｈ，６Ｈ−５−オキサ−２，３，１０ｂ−トリアザ−ベンゾ［ｅ］アズレン |
| DK2861566T3 (en) | 2012-06-13 | 2017-02-27 | Hoffmann La Roche | NEW DIAZASPIROCYCLOALKANES AND AZASPIROCYCLOALKANES |
| CN102766674A (zh) * | 2012-07-25 | 2012-11-07 | 辉源生物科技（上海）有限公司 | 食蟹猴抗利尿激素受体v1a拮抗剂筛选平台的建立 |
| CN104684915B (zh) | 2012-09-25 | 2017-10-31 | 霍夫曼-拉罗奇有限公司 | 新型双环衍生物 |
| AR095079A1 (es) | 2013-03-12 | 2015-09-16 | Hoffmann La Roche | Derivados de octahidro-pirrolo[3,4-c]-pirrol y piridina-fenilo |
| WO2015024819A1 (en) * | 2013-08-19 | 2015-02-26 | F. Hoffmann-La Roche Ag | V1a antagonists to treat phase shift sleep disorders |
| CA2923523A1 (en) | 2013-11-26 | 2015-06-04 | F. Hoffmann-La Roche Ag | New octahydro-cyclobuta [1,2-c;3,4-c']dipyrrol-2-yl |
| CN105793263B (zh) | 2013-12-05 | 2019-08-23 | 豪夫迈·罗氏有限公司 | 一种苯并[e]薁化合物及其晶型的合成 |
| EP3590939A1 (en) | 2014-03-26 | 2020-01-08 | F. Hoffmann-La Roche AG | Bicyclic compounds as autotaxin (atx) and lysophosphatidic acid (lpa) production inhibitors |
| EP3122751B1 (en) | 2014-03-26 | 2019-10-30 | F.Hoffmann-La Roche Ag | Condensed [1,4]diazepine compounds as autotaxin (atx) and lysophosphatidic acid (lpa) production inhibitors |
| MA41898A (fr) | 2015-04-10 | 2018-02-13 | Hoffmann La Roche | Dérivés de quinazolinone bicyclique |
| KR20180043837A (ko) | 2015-09-04 | 2018-04-30 | 에프. 호프만-라 로슈 아게 | 페녹시메틸 유도체 |
| EP3353176B1 (en) | 2015-09-24 | 2022-01-19 | F. Hoffmann-La Roche AG | Bicyclic compounds as atx inhibitors |
| WO2017050791A1 (en) | 2015-09-24 | 2017-03-30 | F. Hoffmann-La Roche Ag | New bicyclic compounds as dual atx/ca inhibitors |
| CA2983782A1 (en) | 2015-09-24 | 2017-03-30 | F. Hoffmann-La Roche Ag | Bicyclic compounds as atx inhibitors |
| JP6845230B2 (ja) | 2015-09-24 | 2021-03-17 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | デュアルａｔｘ／ｃａ阻害剤としての新規な二環式化合物 |
| CN110382484B (zh) | 2017-03-16 | 2022-12-06 | 豪夫迈·罗氏有限公司 | 新的作为atx抑制剂的二环化合物 |
| EP3596059B1 (en) | 2017-03-16 | 2024-04-24 | F. Hoffmann-La Roche AG | Heterocyclic compounds useful as dual atx/ca inhibitors |
| US11186577B2 (en) * | 2017-06-05 | 2021-11-30 | Blackthorn Therapeutics, Inc. | Vasopressin receptor antagonists and products and methods related thereto |
| HU231206B1 (hu) * | 2017-12-15 | 2021-10-28 | Richter Gedeon Nyrt. | Triazolobenzazepinek |
| TW201938171A (zh) | 2017-12-15 | 2019-10-01 | 匈牙利商羅特格登公司 | 作為血管升壓素Ｖ１ａ受體拮抗劑之三環化合物 |
| CN111170983B (zh) * | 2019-12-26 | 2021-07-09 | 中国农业大学 | 一种苄硫基乙酰胺类化合物及其制备方法与应用 |
| TWI804119B (zh) * | 2020-12-21 | 2023-06-01 | 大陸商上海濟煜醫藥科技有限公司 | 三氮唑類三并環衍生物及其製備方法和應用 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8823475D0 (en) * | 1988-10-06 | 1988-11-16 | Merck Sharp & Dohme | Chemical compounds |
| US5438035A (en) * | 1994-06-24 | 1995-08-01 | American Cyanamid Company | Methods for controlling undesirable plant species with benzodiazepine compounds |
| US5753648A (en) * | 1995-01-17 | 1998-05-19 | American Cyanamid Company | Tricyclic benzazepine vasopressin antagonists |
| CN1330653C (zh) * | 1996-11-01 | 2007-08-08 | 惠氏公司 | 5h－吡咯并[2,1－c][1,4]－苯并二氮杂䓬的3－甲酰胺衍生物 |
| KR100771184B1 (ko) * | 1999-01-19 | 2007-10-29 | 오르토-맥네일 파마슈티칼, 인코퍼레이티드 | 바소프레신 수용체 길항제로서의 트리사이클릭 벤조디아제핀 |
| US7109193B2 (en) * | 2001-04-12 | 2006-09-19 | Wyeth | Tricyclic diazepines tocolytic oxytocin receptor antagonists |
-
2003
- 2003-02-19 GB GBGB0303852.8A patent/GB0303852D0/en not_active Ceased
-
2004
- 2004-02-09 WO PCT/IB2004/000432 patent/WO2004074291A1/en active IP Right Grant
- 2004-02-09 CN CNA2004800047089A patent/CN1751047A/zh active Pending
- 2004-02-17 PE PE2004000165A patent/PE20050222A1/es not_active Application Discontinuation
- 2004-02-18 AR ARP040100495A patent/AR043210A1/es not_active Application Discontinuation
- 2004-02-18 PA PA20048596101A patent/PA8596101A1/es unknown
- 2004-02-18 GT GT200400020A patent/GT200400020A/es unknown
- 2004-02-18 CL CL200400293A patent/CL2004000293A1/es unknown
- 2004-02-18 TW TW093103978A patent/TW200500367A/zh unknown
- 2004-02-19 UY UY28201A patent/UY28201A1/es unknown
- 2004-02-19 NL NL1025527A patent/NL1025527C2/nl not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| AR043210A1 (es) | 2005-07-20 |
| GB0303852D0 (en) | 2003-03-26 |
| UY28201A1 (es) | 2004-09-30 |
| GT200400020A (es) | 2004-09-21 |
| CN1751047A (zh) | 2006-03-22 |
| NL1025527C2 (nl) | 2005-03-14 |
| CL2004000293A1 (es) | 2005-01-07 |
| WO2004074291A1 (en) | 2004-09-02 |
| NL1025527A1 (nl) | 2004-08-23 |
| PA8596101A1 (es) | 2005-08-04 |
| PE20050222A1 (es) | 2005-04-13 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| TW200500367A (en) | Triazole compounds useful in therapy | |
| WO2005028445A3 (en) | Derivatives of n-(1h-indazolyl)- and n-(1h-indolyl)-urea as well as related compounds as modulators of the vanilloid-1 receptor (vr1) for the treatment of pain | |
| HU9300274D0 (en) | Phosphonoxical as well as carbonatic derivatives of taxole and medical preparatives containing said active substance | |
| JP2006521359A5 (es) | ||
| WO2005092858A3 (en) | Alpha aryl or heteroaryl methyl beta piperidino propanamide compounds as orl1-receptor antagonist | |
| HUP0300693A2 (hu) | Eljárás epotilon-analógok és -intermedierek előállítására | |
| BR0306292A (pt) | Composto de éster e uso medicinal do mesmo | |
| AR046297A1 (es) | Inhibidores de la dpp - iv metodos para prepararlos y composiciones farmaceuticas que los contienen como agente activo | |
| EP1312601A4 (en) | CARBOXYLENE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF, AND MEDICAMENTS CONTAINING THEM AS AN ACTIVE SUBSTANCE | |
| CO5690599A2 (es) | Derivados de 3-(4-aminofenil) tienopirimid-4-ona como antagonistas mch r1 para el tratamiento de obesidad, diabetes, depresion y ansiedad | |
| CO4480737A1 (es) | Compuestos parasiticidas | |
| NZ307505A (en) | Arylglycinamide derivatives, methods of producing these substances and pharmaceutical compositions containing such compounds | |
| NO20015172L (no) | 1-metyl-erytromycin-derivater | |
| BG101402A (en) | Apoliprotein-b synthesis inhibitors | |
| NO20054669L (no) | Substituerte kinobenzoxazinanaloger | |
| WO2000047584A3 (de) | Epothilon-derivate, verfahren zu deren herstellung und ihre pharmazeutische verwendung | |
| EP1634874A4 (en) | imidazolidine | |
| RS20050638A (en) | Triazole compounds useful in therapy | |
| DK568088D0 (da) | 3,5-dihydroxy-6,8-nonadiensyre-forbindelser og farmaceutiske praeparater indeholdende disse samt 5-hydroxy-3-oxo-6,8-nonadiensyreester-forbindelser til anvendelse som udgangsmateriale ved deres fremstilling | |
| HUP0303249A2 (hu) | Gombaellenes hatású vízoldékony triazolvegyületek és ezeket tartalmazó gyógyszerkészítmények | |
| HUP9903526A2 (hu) | Pirimidinszármazékok és az ezeket tartalmazó gyógyszerkészítmények | |
| ATE172959T1 (de) | Acylphenylglycin-derivat und dieses als aktivbestandteil enthaltendes vorbeugungs -und heilmittel gegen durch erhöhte collagenaseaktivität verursachte krankheiten | |
| WO2002017954A1 (fr) | Medicaments contre la maladie de parkinson | |
| DK1161424T3 (da) | Hidtil ukendte diazolderivater som serotonerge midler | |
| DOP2004000827A (es) | Compuestos de traizol utiles en terapia |