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TR200001580T2 - Spesifik etkinliği yüksek eritropoyetin - Google Patents

Spesifik etkinliği yüksek eritropoyetin

Info

Publication number
TR200001580T2
TR200001580T2 TR2000/01580T TR200001580T TR200001580T2 TR 200001580 T2 TR200001580 T2 TR 200001580T2 TR 2000/01580 T TR2000/01580 T TR 2000/01580T TR 200001580 T TR200001580 T TR 200001580T TR 200001580 T2 TR200001580 T2 TR 200001580T2
Authority
TR
Turkey
Prior art keywords
specific activity
high specific
erythropoietin
compounds
relates
Prior art date
Application number
TR2000/01580T
Other languages
English (en)
Inventor
Burg Josef
Sellinger Karl-Heinz
Haselbeck Anton
Koll Hans
Original Assignee
Roche Diagnostics Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE1997153681 external-priority patent/DE19753681A1/de
Application filed by Roche Diagnostics Gmbh filed Critical Roche Diagnostics Gmbh
Publication of TR200001580T2 publication Critical patent/TR200001580T2/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/505—Erythropoietin [EPO]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/036—Fusion polypeptide containing a localisation/targetting motif targeting to the medium outside of the cell, e.g. type III secretion
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
    • C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Bu bulus spesifik etkinligi yüksek yeni EPO bilesimlerine iliskindir. bu bilesimlerin özelligi karbonhidrat yapisinda yüksek N-asetil-laktosamin birim muhteviyati ve/veya dört antenli dallardir. Bulus böyle EPO ürünleri üretmek için bir isleme de iliskindir.
TR2000/01580T 1997-12-03 1998-12-03 Spesifik etkinliği yüksek eritropoyetin TR200001580T2 (tr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE1997153681 DE19753681A1 (de) 1997-12-03 1997-12-03 Erythropoietin mit hoher spezifischer Aktivität
EP98113415 1998-07-17

Publications (1)

Publication Number Publication Date
TR200001580T2 true TR200001580T2 (tr) 2000-12-21

Family

ID=26042142

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2000/01580T TR200001580T2 (tr) 1997-12-03 1998-12-03 Spesifik etkinliği yüksek eritropoyetin

Country Status (12)

Country Link
US (1) US7659373B2 (tr)
EP (1) EP1037921B1 (tr)
JP (3) JP4220125B2 (tr)
KR (1) KR100390325B1 (tr)
CN (1) CN1280309C (tr)
AR (1) AR022358A1 (tr)
AU (1) AU744086B2 (tr)
BR (1) BR9813391C1 (tr)
CA (1) CA2309810C (tr)
ES (1) ES2523599T3 (tr)
TR (1) TR200001580T2 (tr)
WO (1) WO1999028346A1 (tr)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2686899B1 (fr) 1992-01-31 1995-09-01 Rhone Poulenc Rorer Sa Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant.
US7297680B2 (en) 1999-04-15 2007-11-20 Crucell Holland B.V. Compositions of erythropoietin isoforms comprising Lewis-X structures and high sialic acid content
EP2067488A1 (en) 2000-04-12 2009-06-10 Human Genome Sciences, Inc. Albumin fusion proteins
CA2471363C (en) 2001-12-21 2014-02-11 Human Genome Sciences, Inc. Albumin fusion proteins
US20050153879A1 (en) * 2002-03-26 2005-07-14 Monica Svetina Process for the preparation of a desired erythropoietin glyco-isoform profile
ATE359358T1 (de) 2002-07-15 2007-05-15 Immunex Corp Verfahren und medien zur kontrolle der sialysierung von proteinen, die von säugetierzellen produziert werden
KR100473659B1 (ko) * 2002-10-25 2005-03-15 드림바이오젠 주식회사 당사슬 위치에 위치선택적 수식법으로 유용한 고분자를수식시킨 혼성형 단백질의 제조방법
KR100473658B1 (ko) * 2002-10-25 2005-03-10 드림바이오젠 주식회사 위치 선택적 수식법에 의한 혼성형 단백질 치료제 개발을 위한 형질전환 효모 시스템
CA2513213C (en) 2003-01-22 2013-07-30 Human Genome Sciences, Inc. Albumin fusion proteins
CN100383238C (zh) 2003-05-09 2008-04-23 克鲁塞尔荷兰公司 E1-永生化的细胞培养物及培养所述细胞以提高从中获取的产物产量的方法
DE102004027816A1 (de) 2004-06-08 2006-01-05 Bioceuticals Arzneimittel Ag Verfahren zur Reinigung von Erythropoietin
WO2008065372A2 (en) 2006-11-28 2008-06-05 Nautilus Biotech, S.A. Modified erythropoietin polypeptides and uses thereof for treatment
US8255487B2 (en) * 2008-05-16 2012-08-28 Integrated Illumination Systems, Inc. Systems and methods for communicating in a lighting network
ES2435272T3 (es) * 2008-09-23 2013-12-17 F. Hoffmann-La Roche Ag Purificación de la eritropoyetina
JP5728016B2 (ja) 2009-09-23 2015-06-03 ラチオファーマ ゲーエムベーハー 組換えヒトエリスロポエチン（ｅｐｏ）を精製するためのプロセス、このようにして精製されたｅｐｏおよびこれを含む医薬組成物
JP5773454B2 (ja) 2010-01-15 2015-09-02 バイオ−ラッド ラボラトリーズ インコーポレーティッド アパタイトの表面中和方法
US8895707B2 (en) * 2010-08-18 2014-11-25 Bio-Rad Laboratories, Inc. Elution of proteins from hydroxyapatite resins without resin deterioration
JP5918697B2 (ja) 2010-10-15 2016-05-18 Ｊｃｒファーマ株式会社 糖鎖の非還元末端がマンノース残基である糖蛋白質の製造方法
EP2670704B1 (en) 2011-02-02 2018-12-12 Bio-Rad Laboratories, Inc. Apatite surface neutralization with alkali solutions
KR101443257B1 (ko) 2011-10-18 2014-09-19 주식회사 종근당 낮은 등전점을 갖는 에리스로포이에틴 유사체의 정제방법
CN104507952B (zh) 2012-05-30 2018-08-10 生物辐射实验室股份有限公司 基于磷灰石的色谱树脂的原位恢复
JP6652334B2 (ja) 2014-05-31 2020-02-19 Ｊｃｒファーマ株式会社 ウリジンとｎ−アセチル−ｄ−マンノサミンとを含有する培地
US10099157B2 (en) 2014-06-23 2018-10-16 Bio-Rad Laboratories, Inc. Apatite in-situ restoration
CN105392569B (zh) 2014-06-23 2019-08-20 生物辐射实验室股份有限公司 磷灰石预处理
EP3570871B1 (en) 2017-03-20 2020-11-18 H. Hoffnabb-La Roche Ag Method for in vitro glycoengineering of an erythropoiesis stimulating protein
WO2022063082A1 (zh) * 2020-09-22 2022-03-31 美国杰科实验室有限公司 一种糖基化修饰的促红细胞生成素及其应用
AU2023374183A1 (en) 2022-11-02 2025-03-20 F. Hoffmann-La Roche Ag Method for producing glycoprotein compositions

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4745099A (en) * 1985-02-06 1988-05-17 Chugai Seiyaku Kabushiki Kaisha Pharmaceutical composition for the treatment of the anemia of malignant tumors
US4954437A (en) * 1986-09-15 1990-09-04 Integrated Genetics, Inc. Cell encoding recombinant human erythropoietin
US4835260A (en) * 1987-03-20 1989-05-30 Genetics Institute, Inc. Erythropoietin composition
US5047335A (en) * 1988-12-21 1991-09-10 The Regents Of The University Of Calif. Process for controlling intracellular glycosylation of proteins
DE3924746A1 (de) * 1989-07-26 1991-01-31 Behringwerke Ag Erythropoietin (epo)-peptide und dagegen gerichtete antikoerper
US5856298A (en) * 1989-10-13 1999-01-05 Amgen Inc. Erythropoietin isoforms
DE4028800A1 (de) * 1990-09-11 1992-03-12 Behringwerke Ag Gentechnische sialylierung von glykoproteinen
PT101031B (pt) 1991-11-05 2002-07-31 Transkaryotic Therapies Inc Processo para o fornecimento de proteinas por terapia genetica
US5641670A (en) 1991-11-05 1997-06-24 Transkaryotic Therapies, Inc. Protein production and protein delivery
TW402639B (en) 1992-12-03 2000-08-21 Transkaryotic Therapies Inc Protein production and protein delivery
US5459031A (en) * 1993-11-05 1995-10-17 Amgen Inc. Methods for controlling sialic acid derivatives in recombinant glycoproteins
FR2716682B1 (fr) * 1994-01-28 1996-04-26 Centre Nat Rech Scient Procédé de préparation de virus adéno-associés (AAV) recombinants et utilisations.
CA2180261C (en) * 1994-11-01 2003-03-18 Aruto Yoshida Peptide sequence that forms mucin sugar chain and technique for modifying protein to be linked with mucin sugar chain
IL118201A (en) 1995-05-11 2004-12-15 Roche Diagnostics Gmbh Preparation comprising a protein with human erythropoietin activity which is free of serum and non-recombinant mammalian protein and process for the preparation thereof
DK0986644T3 (da) 1997-07-23 2007-01-29 Roche Diagnostics Gmbh Fremstilling af erythropoietin ved endogen genaktivering med virale promotorer

Also Published As

Publication number Publication date
JP2003238593A (ja) 2003-08-27
ES2523599T3 (es) 2014-11-27
KR20010024681A (ko) 2001-03-26
AR022358A1 (es) 2002-09-04
EP1037921B1 (de) 2014-09-24
US20050288220A1 (en) 2005-12-29
WO1999028346A1 (de) 1999-06-10
JP3673261B2 (ja) 2005-07-20
JP4234647B2 (ja) 2009-03-04
CN1280586A (zh) 2001-01-17
AU2158199A (en) 1999-06-16
CA2309810C (en) 2014-07-08
AU744086B2 (en) 2002-02-14
CN1280309C (zh) 2006-10-18
BR9813391C1 (pt) 2021-05-25
CA2309810A1 (en) 1999-06-10
EP1037921A1 (de) 2000-09-27
JP4220125B2 (ja) 2009-02-04
BR9813391A (pt) 2000-10-10
KR100390325B1 (ko) 2003-07-07
US7659373B2 (en) 2010-02-09
JP2001525338A (ja) 2001-12-11
JP2004339234A (ja) 2004-12-02

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