TR199901831T2 - Peptides composed of a T-cell epitope specific to Collagen-II. - Google Patents
Peptides composed of a T-cell epitope specific to Collagen-II.Info
- Publication number
- TR199901831T2 TR199901831T2 TR1999/01831T TR9901831T TR199901831T2 TR 199901831 T2 TR199901831 T2 TR 199901831T2 TR 1999/01831 T TR1999/01831 T TR 1999/01831T TR 9901831 T TR9901831 T TR 9901831T TR 199901831 T2 TR199901831 T2 TR 199901831T2
- Authority
- TR
- Turkey
- Prior art keywords
- amino acid
- gly
- xaa
- residue
- collagen
- Prior art date
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 3
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 2
- 210000001744 T-lymphocyte Anatomy 0.000 title 1
- 125000000539 amino acid group Chemical group 0.000 abstract 3
- 150000001413 amino acids Chemical group 0.000 abstract 3
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 abstract 2
- 125000001931 aliphatic group Chemical group 0.000 abstract 2
- 229940024606 amino acid Drugs 0.000 abstract 2
- 235000001014 amino acid Nutrition 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- DCXYFEDJOCDNAF-UHFFFAOYSA-N Asparagine Natural products OC(=O)C(N)CC(N)=O DCXYFEDJOCDNAF-UHFFFAOYSA-N 0.000 abstract 1
- 208000023275 Autoimmune disease Diseases 0.000 abstract 1
- DCXYFEDJOCDNAF-REOHCLBHSA-N L-asparagine Chemical compound OC(=O)[C@@H](N)CC(N)=O DCXYFEDJOCDNAF-REOHCLBHSA-N 0.000 abstract 1
- 125000000637 arginyl group Chemical group N[C@@H](CCCNC(N)=N)C(=O)* 0.000 abstract 1
- 229960001230 asparagine Drugs 0.000 abstract 1
- 235000009582 asparagine Nutrition 0.000 abstract 1
- 201000003068 rheumatic fever Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Transplantation (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
Bulus, izleyen (I) formülü ile temsil edilen bir amino asit sekansina sahip, izole edilmis bir peptit saglamaktadir: A1-Xaa-Gly-A4-A5-Gly-A7-Xaa-Gly; sözkonusu formülde A1, aromatik ya da alifatik bir yan zincire sahip bir amino asit artigini temsil etmektedir; A4, bir asparajin ya da arginin artigini ya da aromatik ya da alifatik bir yan zincire sahip bir amino asit artigini temsil etmektedir; A5 dogal olarak var olan herhangi bir amino asidi temsil etmektedir; A7, negatif yüklü bir artigi olan bir amino asidi temsil etmektedir; Xaa, herhangi bir amino asit artigini temsil etmektedir; ve Gly, bir glisin artigini temsil etmaktadir; bulus geregince ayrica, bu tür peptitlerin tibbi tedavisinde, özellikle de romatizmal artrit gibi özbagisiklik hastaliklarinin tedavisinde kullanimi de saglanmistir.The invention provides an isolated peptide with an amino acid sequence represented by formula (I): A1-Xaa-Gly-A4-A5-Gly-A7-Xaa-Gly; In said formula, A1 represents an amino acid residue having an aromatic or aliphatic side chain; A4 represents an asparagine or arginine residue or an amino acid residue having an aromatic or aliphatic side chain; A5 represents any naturally occurring amino acid; A7 represents an amino acid with a negatively charged residue; Xaa represents any amino acid residue; and Gly represents an increased glycine; In accordance with the invention, it has also been used for the medical treatment of such peptides, especially for the treatment of autoimmune diseases such as rheumatic arthritis.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE9700301A SE9700301D0 (en) | 1997-01-31 | 1997-01-31 | New compound |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TR199901831T2 true TR199901831T2 (en) | 1999-10-21 |
Family
ID=20405590
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TR1999/01831T TR199901831T2 (en) | 1997-01-31 | 1998-01-29 | Peptides composed of a T-cell epitope specific to Collagen-II. |
Country Status (19)
| Country | Link |
|---|---|
| EP (1) | EP1007547A1 (en) |
| JP (1) | JP2001511143A (en) |
| KR (1) | KR20000070542A (en) |
| CN (1) | CN1246125A (en) |
| AU (1) | AU744907B2 (en) |
| BR (1) | BR9811250A (en) |
| CA (1) | CA2278638A1 (en) |
| EE (1) | EE9900334A (en) |
| HU (1) | HUP0000836A3 (en) |
| ID (1) | ID22802A (en) |
| IL (1) | IL131045A0 (en) |
| IS (1) | IS5138A (en) |
| NO (1) | NO993684L (en) |
| NZ (1) | NZ336745A (en) |
| PL (1) | PL334877A1 (en) |
| SE (1) | SE9700301D0 (en) |
| SK (1) | SK102199A3 (en) |
| TR (1) | TR199901831T2 (en) |
| WO (1) | WO1998033811A1 (en) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AUPO571297A0 (en) * | 1997-03-19 | 1997-04-10 | Montech Medical Developments Pty Ltd | Method for the diagnosis of rheumatoid arthritis |
| US7148020B2 (en) | 2001-07-12 | 2006-12-12 | Arexis Ab | Triple polypeptide complexes |
| MXPA04002348A (en) * | 2001-09-14 | 2004-09-28 | Biora Bioex Ab | Enamel matrix protein compositions for modulating immune response. |
| CN1169829C (en) * | 2002-06-27 | 2004-10-06 | 北京大学人民医院 | Non-T cell binding peptides and uses thereof |
| WO2008130217A1 (en) * | 2006-08-08 | 2008-10-30 | Applied Nanosystems B.V. | Cyclic angiotensin analogs |
| KR20170002734U (en) | 2016-01-21 | 2017-07-31 | 김인수 | The construction to automatic amputate of the wood |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH08151396A (en) * | 1994-11-28 | 1996-06-11 | Teijin Ltd | Hla-binding oligopeptide and immunomodulating agent containing the compound |
| WO1996020950A2 (en) * | 1995-01-06 | 1996-07-11 | Immulogic Pharmaceutical Corporation | Compositions and methods for treating rheumatoid arthritis |
-
1997
- 1997-01-31 SE SE9700301A patent/SE9700301D0/en unknown
-
1998
- 1998-01-29 CN CN98802141A patent/CN1246125A/en active Pending
- 1998-01-29 EE EEP199900334A patent/EE9900334A/en unknown
- 1998-01-29 PL PL98334877A patent/PL334877A1/en unknown
- 1998-01-29 KR KR1019997006787A patent/KR20000070542A/en not_active Withdrawn
- 1998-01-29 IL IL13104598A patent/IL131045A0/en unknown
- 1998-01-29 NZ NZ336745A patent/NZ336745A/en unknown
- 1998-01-29 BR BR9811250-3A patent/BR9811250A/en not_active IP Right Cessation
- 1998-01-29 TR TR1999/01831T patent/TR199901831T2/en unknown
- 1998-01-29 HU HU0000836A patent/HUP0000836A3/en unknown
- 1998-01-29 ID IDW990738A patent/ID22802A/en unknown
- 1998-01-29 EP EP98902337A patent/EP1007547A1/en not_active Withdrawn
- 1998-01-29 SK SK1021-99A patent/SK102199A3/en unknown
- 1998-01-29 WO PCT/SE1998/000128 patent/WO1998033811A1/en not_active Application Discontinuation
- 1998-01-29 JP JP53278598A patent/JP2001511143A/en active Pending
- 1998-01-29 CA CA002278638A patent/CA2278638A1/en not_active Abandoned
- 1998-01-29 AU AU58892/98A patent/AU744907B2/en not_active Ceased
-
1999
- 1999-07-28 IS IS5138A patent/IS5138A/en unknown
- 1999-07-29 NO NO993684A patent/NO993684L/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| NO993684D0 (en) | 1999-07-29 |
| AU5889298A (en) | 1998-08-25 |
| ID22802A (en) | 1999-12-09 |
| NZ336745A (en) | 2001-09-28 |
| KR20000070542A (en) | 2000-11-25 |
| NO993684L (en) | 1999-09-02 |
| CA2278638A1 (en) | 1998-08-06 |
| SK102199A3 (en) | 2000-08-14 |
| HUP0000836A3 (en) | 2001-04-28 |
| PL334877A1 (en) | 2000-03-27 |
| JP2001511143A (en) | 2001-08-07 |
| CN1246125A (en) | 2000-03-01 |
| IS5138A (en) | 1999-07-28 |
| BR9811250A (en) | 2000-09-26 |
| IL131045A0 (en) | 2001-01-28 |
| EE9900334A (en) | 2000-02-15 |
| SE9700301D0 (en) | 1997-01-31 |
| WO1998033811A1 (en) | 1998-08-06 |
| EP1007547A1 (en) | 2000-06-14 |
| AU744907B2 (en) | 2002-03-07 |
| HUP0000836A2 (en) | 2000-11-28 |
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