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TNSN98084A1 - Derives de macrolides substitues en position c-4 - Google Patents

Derives de macrolides substitues en position c-4

Info

Publication number
TNSN98084A1
TNSN98084A1 TNTNSN98084A TNSN98084A TNSN98084A1 TN SN98084 A1 TNSN98084 A1 TN SN98084A1 TN TNSN98084 A TNTNSN98084 A TN TNSN98084A TN SN98084 A TNSN98084 A TN SN98084A TN SN98084 A1 TNSN98084 A1 TN SN98084A1
Authority
TN
Tunisia
Prior art keywords
derivatives
infections
compounds
macrolides
substituted
Prior art date
Application number
TNTNSN98084A
Other languages
English (en)
Inventor
Scott Bronk Brian
Kaneko Takushi
Anthony Letavic Michael
Cheng Hengmiao
Alan Glazer Edward
Vera Yang Bingwei
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of TNSN98084A1 publication Critical patent/TNSN98084A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

L’INVENTION CONCERNE DES COMPOSES DE FORMULE I DANS LAQUELLE R1, R2, R3, R4 ET X REPRESENTENT DIVERS RADICAUX. ELLE CONCERNE EGALEMENT DES COMPOSITIONS PHARMACEUTIQUES LES CONTENANT, AINSI QUE DES PROCEDES POUR LEUR PREPARATION. APPLICATION : UTILISATION DE CES COMPOSES ET COMPOSITIONS POUR LE TRAITEMENT DE DIVERSES INFECTIONS BACTERIENNES, INFECTIONS PAR DES PROTOZOAIRES ET TROUBLES LIES A CES INFECTIONS.
TNTNSN98084A 1997-06-11 1998-06-10 Derives de macrolides substitues en position c-4 TNSN98084A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US4998097P 1997-06-11 1997-06-11

Publications (1)

Publication Number Publication Date
TNSN98084A1 true TNSN98084A1 (fr) 2005-03-15

Family

ID=21962765

Family Applications (1)

Application Number Title Priority Date Filing Date
TNTNSN98084A TNSN98084A1 (fr) 1997-06-11 1998-06-10 Derives de macrolides substitues en position c-4

Country Status (39)

Country Link
EP (1) EP0988309B1 (fr)
JP (1) JP3262806B2 (fr)
KR (1) KR100369959B1 (fr)
CN (1) CN1145636C (fr)
AP (1) AP1189A (fr)
AR (1) AR013085A1 (fr)
AT (1) ATE310742T1 (fr)
AU (1) AU745006C (fr)
BG (1) BG64357B1 (fr)
BR (1) BR9810097A (fr)
CA (1) CA2293397C (fr)
CO (1) CO4950584A1 (fr)
DE (1) DE69832486T2 (fr)
DZ (1) DZ2515A1 (fr)
EA (1) EA002440B1 (fr)
ES (1) ES2251081T3 (fr)
GT (1) GT199800075A (fr)
HN (1) HN1998000074A (fr)
HR (1) HRP980315A2 (fr)
HU (1) HUP0004076A3 (fr)
ID (1) ID24530A (fr)
IL (1) IL132808A (fr)
IS (1) IS1979B (fr)
MA (1) MA24563A1 (fr)
MY (1) MY133027A (fr)
NO (1) NO315560B1 (fr)
NZ (1) NZ500652A (fr)
OA (1) OA11226A (fr)
PA (1) PA8452001A1 (fr)
PE (1) PE79999A1 (fr)
PL (1) PL337497A1 (fr)
SK (1) SK168299A3 (fr)
TN (1) TNSN98084A1 (fr)
TW (2) TWI224106B (fr)
UA (1) UA70298C2 (fr)
UY (1) UY25041A1 (fr)
WO (1) WO1998056801A1 (fr)
YU (1) YU62999A (fr)
ZA (1) ZA985016B (fr)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1779853A3 (fr) * 1997-09-10 2010-01-27 Merial Ltd. 9a-azalides en tant qu'agents anti-microbiens à usage vétérinaire
US6339063B1 (en) 1997-09-10 2002-01-15 Merck & Co., Inc. 9a-azalides as veterinary antimicrobial agents
CA2302010C (fr) * 1997-09-10 2010-11-23 Merck & Co., Inc. 9a-azalides utilises comme agents antimicrobiens veterinaires
AP9801420A0 (en) * 1998-01-02 1998-12-31 Pfizer Prod Inc Novel macrolides.
US6043227A (en) * 1998-08-19 2000-03-28 Pfizer Inc. C11 carbamates of macrolide antibacterials
EP1437360A3 (fr) * 1998-08-19 2005-04-06 Pfizer Products Inc. C11-carbamates des macrolides antibactériens
US6100240A (en) * 1998-10-09 2000-08-08 Pfizer Inc Macrolide derivatives
TR200200434T2 (tr) 1998-11-03 2002-09-23 Pfizer Products Inc. Yeni makrolit antibiyotikler.
CA2411293A1 (fr) * 1999-01-28 2000-07-28 Pfizer Products Inc. Nouveaux azalides et procede de fabrication
CA2380455C (fr) * 1999-08-24 2009-06-02 Abbott Laboratories 9a-azalides a activite antibacterienne
US6764996B1 (en) 1999-08-24 2004-07-20 Abbott Laboratories 9a-azalides with antibacterial activity
EP1250343B1 (fr) 2000-01-27 2003-06-25 Pfizer Products Inc. Compositions antibiotiques a base d'azalide
CN1297564C (zh) * 2001-04-27 2007-01-31 辉瑞产品公司 4″－取代－9－脱氧－9a－氮杂－9a－高红霉素A衍生物的制备方法
JP2003040782A (ja) * 2001-05-31 2003-02-13 Pfizer Prod Inc アザリド抗生物質組成物
RU2342398C2 (ru) * 2002-07-08 2008-12-27 Глаксосмитклайн Истраживацки Центар Загреб Д.О.О. Новые нестероидные противовоспалительные вещества, составы и способы их применения
AU2003255851B2 (en) 2002-07-08 2009-07-23 Glaxosmithkline Istrazivacki Centar Zagreb D.O.O. New compounds, compositions and methods for treatment of inflammatory diseases and conditions
ATE429441T1 (de) 2002-07-08 2009-05-15 Glaxosmithkline Zagreb Hybridmoleküle von makroliden mit steroidalen/nicht-steroidalen antientzündlich aktiven molekülen
US7091196B2 (en) 2002-09-26 2006-08-15 Rib-X Pharmaceuticals, Inc. Bifunctional heterocyclic compounds and methods of making and using same
WO2004080391A2 (fr) * 2003-03-10 2004-09-23 Optimer Pharmaceuticals, Inc. Nouveaux agents antibacteriens
WO2005030227A1 (fr) 2003-09-23 2005-04-07 Enanta Pharmaceuticals, Inc. Derives 9a-azalide 11-3c-bicycliques
JP5383037B2 (ja) 2004-02-27 2014-01-08 リブ−エックス ファーマシューティカルズ，インコーポレイテッド 大環状化合物およびそれらを製造し使用する方法
WO2009019868A1 (fr) 2007-08-06 2009-02-12 Taisho Pharmaceutical Co., Ltd. Composé 10a-azalide réticulé en position 10a et en position 12
US9453042B2 (en) 2007-10-25 2016-09-27 Cempra Pharmaceuticals, Inc. Process for the preparation of macrolide antibacterial agents
WO2009139181A1 (fr) 2008-05-15 2009-11-19 大正製薬株式会社 Composé 10a-azalide ayant une structure de cycle à 4 chaînons
WO2010048600A1 (fr) 2008-10-24 2010-04-29 Cempra Pharmaceuticals, Inc. Procédés de traitement de maladies résistantes en utilisant des macrolides contenant du triazole
US9937194B1 (en) 2009-06-12 2018-04-10 Cempra Pharmaceuticals, Inc. Compounds and methods for treating inflammatory diseases
WO2012038372A1 (fr) * 2010-09-20 2012-03-29 Novartis Ag Nouveau procédé de préparation de 9-déoxo-9a-aza-9a-homoérythromycine a modifiée dans le c-4'' du cycle cladinose par un groupe époxyde
AR085286A1 (es) * 2011-02-21 2013-09-18 Taisho Pharmaceutical Co Ltd Derivado de macrolido sustituido en la posicion c-4
CA2868262A1 (fr) 2012-03-27 2013-10-03 Cempra Pharmaceuticals, Inc. Formulations parenterales pour l'administration d'antibiotiques macrolides
JP5857008B2 (ja) * 2012-08-20 2016-02-10 大正製薬株式会社 Ｃ−４”位置換マクロライド誘導体を含有する医薬
CA2908575C (fr) * 2013-04-04 2021-11-16 President And Fellows Of Harvard College Macrolides et leurs procedes de preparation et d'utilisation
CN105669798B (zh) * 2013-08-23 2019-07-26 普莱柯生物工程股份有限公司 一种大环内酯类化合物
CN103965273B (zh) * 2013-08-23 2016-05-25 普莱柯生物工程股份有限公司 一种大环内酯类化合物
AR102810A1 (es) 2014-08-18 2017-03-29 Taisho Pharmaceutical Co Ltd Derivado de macrólido sustituido en la posición c-4
EP3211997A4 (fr) 2014-10-08 2018-10-24 President and Fellows of Harvard College Kétolides à 14 chaînons et leurs procédés de préparation et d'utilisation
US10640528B2 (en) 2015-03-25 2020-05-05 President And Fellows Of Havard College Macrolides with modified desosamine sugars and uses thereof
CN108003207B (zh) 2017-12-19 2019-05-10 海门慧聚药业有限公司 制备泰拉霉素的方法
MX2022011242A (es) * 2020-03-12 2022-12-15 Zoetis Services Llc Inmunomodulación de o-het/aril azálidos.

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4150220A (en) * 1977-02-04 1979-04-17 Pfizer Inc. Semi-synthetic 4"-erythromycin A derivatives
SE445223B (sv) * 1977-02-04 1986-06-09 Pfizer Sett att framstella 4"-amino-erytomylin-a-derivat
SI8110592A8 (en) * 1981-03-06 1996-06-30 Pliva Pharm & Chem Works Process for preparing of n-methyl-11-aza-10-deoxo-10-dihydroerythromycine a and derivatives thereof
US4474768A (en) * 1982-07-19 1984-10-02 Pfizer Inc. N-Methyl 11-aza-10-deoxo-10-dihydro-erytromycin A, intermediates therefor
EP0136831B1 (fr) * 1983-09-06 1988-11-09 Pfizer Inc. Dérivés d'azahomoerythromycine B et produits intermédiaires
US4512982A (en) * 1984-04-13 1985-04-23 Pfizer Inc. 9α-Aza-9α-homoerythromycin compounds, pharmaceutical composition and therapeutic method
CA2064634C (fr) * 1991-04-04 1998-08-04 James V. Heck Derives de 9-desoxo-8a-aza-8a-homoerythromycine a modifies en positions 4"- et 8a
US5441939A (en) * 1994-03-04 1995-08-15 Pfizer Inc. 3"-desmethoxy derivatives of erythromycin and azithromycin
US5412982A (en) * 1994-03-10 1995-05-09 Potts; James K. Windsock support

Also Published As

Publication number Publication date
HUP0004076A2 (hu) 2001-04-28
TW200418871A (en) 2004-10-01
KR100369959B1 (ko) 2003-02-12
CA2293397A1 (fr) 1998-12-17
JP2000514097A (ja) 2000-10-24
HUP0004076A3 (en) 2003-05-28
CO4950584A1 (es) 2000-09-01
NO315560B1 (no) 2003-09-22
UY25041A1 (es) 2000-09-29
AU745006B2 (en) 2002-03-07
MA24563A1 (fr) 1998-12-31
BR9810097A (pt) 2000-08-08
HN1998000074A (es) 1999-01-08
HRP980315A2 (en) 1999-04-30
DE69832486T2 (de) 2006-07-27
CN1259955A (zh) 2000-07-12
AP9801254A0 (en) 1998-06-30
EP0988309B1 (fr) 2005-11-23
OA11226A (en) 2003-07-16
IS1979B (is) 2005-01-14
HK1025974A1 (en) 2000-12-01
EA199901014A1 (ru) 2000-06-26
MY133027A (en) 2007-10-31
IL132808A0 (en) 2001-03-19
PA8452001A1 (es) 2000-05-24
AU7228198A (en) 1998-12-30
DE69832486D1 (de) 2005-12-29
CN1145636C (zh) 2004-04-14
EA002440B1 (ru) 2002-04-25
NZ500652A (en) 2001-10-26
IS5250A (is) 1999-11-16
ZA985016B (en) 1999-12-10
BG64357B1 (bg) 2004-11-30
ID24530A (id) 2000-07-20
NO996107D0 (no) 1999-12-10
KR20010013633A (ko) 2001-02-26
EP0988309A1 (fr) 2000-03-29
IL132808A (en) 2004-08-31
BG103969A (en) 2000-07-31
GT199800075A (es) 1999-11-30
WO1998056801A1 (fr) 1998-12-17
CA2293397C (fr) 2004-08-31
PL337497A1 (en) 2000-08-28
ES2251081T3 (es) 2006-04-16
ATE310742T1 (de) 2005-12-15
JP3262806B2 (ja) 2002-03-04
AR013085A1 (es) 2000-12-13
AU745006C (en) 2006-02-23
UA70298A (uk) 2004-10-15
NO996107L (no) 2000-02-10
TWI224106B (en) 2004-11-21
YU62999A (sh) 2002-10-18
PE79999A1 (es) 1999-08-25
SK168299A3 (en) 2000-09-12
UA70298C2 (uk) 2004-10-15
AP1189A (en) 2003-07-16
DZ2515A1 (fr) 2003-02-01

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