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TNSN04151A1 - Derives de nicotinamide utiles comme inhibiteurs de pde4 - Google Patents

Derives de nicotinamide utiles comme inhibiteurs de pde4

Info

Publication number
TNSN04151A1
TNSN04151A1 TNP2004000151A TNSN04151A TNSN04151A1 TN SN04151 A1 TNSN04151 A1 TN SN04151A1 TN P2004000151 A TNP2004000151 A TN P2004000151A TN SN04151 A TNSN04151 A TN SN04151A TN SN04151 A1 TNSN04151 A1 TN SN04151A1
Authority
TN
Tunisia
Prior art keywords
nicotinamide derivatives
pde4 inhibitors
derivatives useful
numerous
preparation
Prior art date
Application number
TNP2004000151A
Other languages
English (en)
Inventor
Simon Bailey
Elisabeth Colette Louise Gautier
Alan John Henderson
Thomas Victor Magee
Anthony Marfat
John Paul Mathias
Dale Gordon Mcleod
Sandra Marina Monaghan
Blanda Luzia Christa Stammen
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0203196A external-priority patent/GB0203196D0/en
Priority claimed from GB0220999A external-priority patent/GB0220999D0/en
Priority claimed from GB0224453A external-priority patent/GB0224453D0/en
Priority claimed from GB0227139A external-priority patent/GB0227139D0/en
Application filed by Pfizer filed Critical Pfizer
Publication of TNSN04151A1 publication Critical patent/TNSN04151A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C07D213/82—Amides; Imides in position 3
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4433—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with oxygen as a ring hetero atom
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/455—Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
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    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
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Abstract

La presente invention concerne des dérivés de nicotinamide de la formule (1) et des procédés pour la préparation de; les intermédiaires utilisés dans la préparation de; des compositions contenant et les utilisations de ses dérivés. Les dérivés de nicotinamide conformes à la présente invention sont des inhibiteurs de la phosphodiestérase-4 et sont utiles dans de nombreuses maladies; de nombreuses et des nombreuses affections; en particulier des maladies ; troubles et affections inflammatoires; alérgiques et respiratoires; ainsi que des plaies.
TNP2004000151A 2002-02-11 2004-08-10 Derives de nicotinamide utiles comme inhibiteurs de pde4 TNSN04151A1 (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB0203196A GB0203196D0 (en) 2002-02-11 2002-02-11 Nicotinamide derivatives useful as pde4 inhibitors
GB0220999A GB0220999D0 (en) 2002-09-10 2002-09-10 Nicotinamide derivatives useful as pde4 inhibitors
GB0224453A GB0224453D0 (en) 2002-10-21 2002-10-21 Nicotinamide derivatives useful as PDE4 inhibitors
GB0227139A GB0227139D0 (en) 2002-11-20 2002-11-20 Nicotinamide derivatives useful as pde4 inhibitors
PCT/IB2003/000439 WO2003068235A1 (fr) 2002-02-11 2003-02-03 Derives de nicotinamide utiles comme inhibiteurs de pde4

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ATE378049T1 (de) 2007-11-15
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ES2292988T3 (es) 2008-03-16
CA2475712C (fr) 2009-11-24
NO20043793L (no) 2004-10-21
CA2475712A1 (fr) 2003-08-21
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MY135856A (en) 2008-07-31
BR0307564A (pt) 2004-12-21
US20030220366A1 (en) 2003-11-27
RS70104A (en) 2007-02-05
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US20060014780A1 (en) 2006-01-19
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MXPA04007737A (es) 2004-10-15
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