TN2011000028A1 - Neutralizing anti-influenza a virus antibodies and uses therof - Google Patents
Neutralizing anti-influenza a virus antibodies and uses therofInfo
- Publication number
- TN2011000028A1 TN2011000028A1 TN2011000028A TN2011000028A TN2011000028A1 TN 2011000028 A1 TN2011000028 A1 TN 2011000028A1 TN 2011000028 A TN2011000028 A TN 2011000028A TN 2011000028 A TN2011000028 A TN 2011000028A TN 2011000028 A1 TN2011000028 A1 TN 2011000028A1
- Authority
- TN
- Tunisia
- Prior art keywords
- influenza
- antibodies
- relates
- neutralizing anti
- virus antibodies
- Prior art date
Links
- 206010022000 influenza Diseases 0.000 title abstract 2
- 241000700605 Viruses Species 0.000 title 1
- 230000003472 neutralizing effect Effects 0.000 title 1
- 102000008394 Immunoglobulin Fragments Human genes 0.000 abstract 2
- 108010021625 Immunoglobulin Fragments Proteins 0.000 abstract 2
- 101710154606 Hemagglutinin Proteins 0.000 abstract 1
- 241000712431 Influenza A virus Species 0.000 abstract 1
- 101710093908 Outer capsid protein VP4 Proteins 0.000 abstract 1
- 101710135467 Outer capsid protein sigma-1 Proteins 0.000 abstract 1
- 101710176177 Protein A56 Proteins 0.000 abstract 1
- 239000000427 antigen Substances 0.000 abstract 1
- 102000036639 antigens Human genes 0.000 abstract 1
- 108091007433 antigens Proteins 0.000 abstract 1
- 210000003719 b-lymphocyte Anatomy 0.000 abstract 1
- 238000003745 diagnosis Methods 0.000 abstract 1
- 239000012634 fragment Substances 0.000 abstract 1
- 239000000185 hemagglutinin Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 210000004180 plasmocyte Anatomy 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 238000012216 screening Methods 0.000 abstract 1
Landscapes
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
The invention relates to antibodies, and antigen binding fragments thereof, that bind to hemagglutinin and neutralize a group 1 subtype and a group 2 subtype of influenza A virus. The invention also relates to nucleic acids that encode, immortalized B cells and cultured single plasma cells that produce, and to epitopes that bind to such antibodies and antibody fragments. In addition, the invention relates to the use of the antibodies, antibody fragments, and epitopes in screening methods as well as in the diagnosis, treatment and prevention of influenza A virus infection.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/IB2009/006616 WO2010010466A2 (en) | 2008-07-25 | 2009-07-27 | Neutralizing anti-influenza a virus antibodies and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TN2011000028A1 true TN2011000028A1 (en) | 2012-09-05 |
Family
ID=55024342
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TN2011000028A TN2011000028A1 (en) | 2009-07-27 | 2011-01-24 | Neutralizing anti-influenza a virus antibodies and uses therof |
Country Status (1)
| Country | Link |
|---|---|
| TN (1) | TN2011000028A1 (en) |
-
2011
- 2011-01-24 TN TN2011000028A patent/TN2011000028A1/en unknown
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