TH156258A - Kinase inhibitor (apoptosis signal-regulating kinase inhibitor) - Google Patents
Kinase inhibitor (apoptosis signal-regulating kinase inhibitor)Info
- Publication number
- TH156258A TH156258A TH1401004319A TH1401004319A TH156258A TH 156258 A TH156258 A TH 156258A TH 1401004319 A TH1401004319 A TH 1401004319A TH 1401004319 A TH1401004319 A TH 1401004319A TH 156258 A TH156258 A TH 156258A
- Authority
- TH
- Thailand
- Prior art keywords
- kinase inhibitor
- compound
- regulating
- apoptosis signal
- apoptosis
- Prior art date
Links
- 230000006907 apoptotic process Effects 0.000 title claims abstract 4
- 229940043355 kinase inhibitor Drugs 0.000 title 2
- 239000003757 phosphotransferase inhibitor Substances 0.000 title 2
- 150000001875 compounds Chemical class 0.000 claims abstract 5
- 108091000080 Phosphotransferase Proteins 0.000 claims abstract 4
- 102000020233 phosphotransferase Human genes 0.000 claims abstract 4
- 239000000126 substance Substances 0.000 claims abstract 3
- 208000007342 Diabetic Nephropathies Diseases 0.000 claims abstract 2
- 101001018196 Homo sapiens Mitogen-activated protein kinase kinase kinase 5 Proteins 0.000 claims abstract 2
- 206010023421 Kidney fibrosis Diseases 0.000 claims abstract 2
- 102100033127 Mitogen-activated protein kinase kinase kinase 5 Human genes 0.000 claims abstract 2
- 208000033679 diabetic kidney disease Diseases 0.000 claims abstract 2
- 201000010099 disease Diseases 0.000 claims abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract 2
- 230000002401 inhibitory effect Effects 0.000 claims abstract 2
- 208000017169 kidney disease Diseases 0.000 claims abstract 2
- 230000030833 cell death Effects 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 230000006882 induction of apoptosis Effects 0.000 claims 1
- 230000011664 signaling Effects 0.000 abstract 1
Abstract
DC60 (15/10/57) การประดิษฐ์นี้เกี่ยวข้องกับสารประกอบของสูตรโครงสร้าง (I) (สูตรเคมี) (I) สารประกอบนี้มีการออกฤทธิ์ยับยั้งไคเนสที่ควบคุมสัญญาณการตายของเซลล์แบบอะพอพโทซิส (apoptosis signal-regulating kinase ("ASK1")) และด้วยเหตุนี้ จึงเป็นประโยชน์ในการบำบัดโรค เช่น โรคไต(kidney disease), โรคไตจากเบาหวาน(diabetic nephropathy) และการเกิดพังผืดในไต (kidney fibrosis) : สิทธิบัตรยา DC60 (15/10/57) This invention involves a compound of structural formula (I) (chemical formula) (I) .This compound has a kinase-inhibiting action that regulates the signaling of apoptosis ( apoptosis signal-regulating kinase ("ASK1")), and hence It is useful in the treatment of diseases such as kidney disease, diabetic nephropathy and kidney fibrosis.
Claims (1)
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TH156258A true TH156258A (en) | 2016-09-16 |
Family
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