TH106943A - Benzimidazolone compounds with anti-active 5-HT4 receptor - Google Patents

Abstract

DC60 (19/11/47) This invention provides compounds of formula (I) (chemical formula) (I) or salts of those substances that are accepted for the pharmaceutical industry and mixtures containing such compounds and their use. For the manufacture of pharmaceuticals for reflux disease of the stomach and esophagus, gastritis and intestinal disorders, displacement disorders. Gastric spontaneous dyspepsia, eczema indigestion, functional indigestion, irritable bowel food group (IBS), constipation, indigestion, esophagitis, gastritis and esophagus, nausea, disease. Central nervous system, Alzheimer's disease, Cognitive disorders, Vomiting, Migraine, Neurological disease, Pain syndrome, Cardiovascular disorders, Heart failure, Cardiac arrhythmias. Loss of stroke, diabetes and apnea syndrome These compounds contain anti-5-HT activity, receptor, and hence useful for treatment. Reflux disease Stomach and esophagus, eczema indigestion, functional indigestion, irritable bowel syndrome or similar in mammals, especially humans. This invention provides compounds of formula (I): (chemical formula) (I) or salts of those substances that are well tolerated by pharmaceuticals and mixtures containing such compounds and their use. For the manufacture of pharmaceuticals for reflux disease of the stomach and esophagus, gastritis and intestinal disorders, displacement disorders. Gastric spontaneous dyspepsia, eczema indigestion, functional indigestion, irritable bowel food group (IBS), constipation, indigestion, esophagitis, gastritis and esophagus, nausea, disease. Central nervous system, Alzheimer's disease, Cognitive disorders, Vomiting, Migraine, Neurological disease, Pain syndrome, Cardiovascular disorders, Heart failure, Cardiac arrhythmias. Loss of stroke, diabetes and apnea syndrome These compounds contain anti-5-HT activity, receptor, and hence useful for treatment. Reflux disease Stomach and esophagus, eczema indigestion, functional indigestion, irritable bowel syndrome or similar in mammals, especially humans: drug patent.

Claims (1)

1. Compounds of formula (I): (Chemical formula) (I) in which Het represents the heterocyclic group containing one atom of nitrogen, which B directly binds. And carbon from 4 to 7 atoms and hetero groups Such cyclic is not replaced or is substituted with a 1 to 4 substitution group independently selected from a group containing 1 (alpha) 1; A represents an L-Kylene group containing from 1 to 4 carbon atoms; B represents a covalent bond or an alkylene group with carbon from 1 to 5 atoms and six: drug patent.