SU789489A1 - Method of preparing 6,10,14-trimethylpentadecanone-2 - Google Patents
Method of preparing 6,10,14-trimethylpentadecanone-2 Download PDFInfo
- Publication number
- SU789489A1 SU789489A1 SU782623812A SU2623812A SU789489A1 SU 789489 A1 SU789489 A1 SU 789489A1 SU 782623812 A SU782623812 A SU 782623812A SU 2623812 A SU2623812 A SU 2623812A SU 789489 A1 SU789489 A1 SU 789489A1
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- SU
- USSR - Soviet Union
- Prior art keywords
- trimethylpentadecanone
- preparing
- trimethyl
- vitamin
- ketone
- Prior art date
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- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Description
1one
Изобретение относитс к органическому синтезу, в частности, к усовершенствованному cnocofSy каталитического восстановлени ненасыщенных кетонов .This invention relates to organic synthesis, in particular, to the improved cnocofSy catalytic reduction of unsaturated ketones.
Продукт гидрировани 6,10,14-триметилпентадекадиен-3 ,5-она-2-(диенового кетона ) 6 ,10 ,14-триметилпентадеканон-2 () используетс дл получени изo(итa, полупродукта витамина Е. Витамин Е, выполн ющий различные функции в организме, примен етс в гормональной терапии при сердечно-сосудистых расстройствах, при лечении р да других заболеваний, кроме того вл етс активным стабилизатором растительных масел и используетс в качестве антиоксиданта.The hydrogenation product of 6, 10, 14-trimethylpentadecadien-3, 5-one-2- (diene ketone) 6, 10, 14-trimethylpentadecanon-2 () is used to obtain vitamin E (a precursor of vitamin E. Vitamin E, performing various functions in the body, used in hormone therapy in cardiovascular disorders, in the treatment of a number of other diseases, in addition to being an active stabilizer of vegetable oils and used as an antioxidant.
Известен способ получени 2,6,10-триметилпентадеканона-14 восстановлением 2,6,10-триметилпентадекатетраен-2 , 6,10,12-он-14 в автоклаве на скелетном никелевом катализаторе при 95-100°С в этиловом спирте до 2,6,10-триметилпентадеканола-14 , с последующим окислением его хромовой смесью в среде уксусной кислоты до 2,6,10-триметилпентадеканона-14 . Выход целевого продукта 69,29% в расчете наA known method for producing 2,6,10-trimethylpentadecanone-14 by reducing 2,6,10-trimethyl pentadetraen-2, 6,10,12-one-14 in an autoclave on a skeletal nickel catalyst at 95-100 ° C in ethyl alcohol to 2 6,10-trimethyl pentadecanol-14, followed by oxidation with its chromic mixture in an acetic acid medium to 2,6,10-trimethyl pentadecanone-14. The yield of the target product is 69.29% per
2,6,10-триметилпентадекатетраен-2 , 6 , 10,12-он-14 1 .2,6,10-trimethyl pentadetraen-2, 6, 10,12-one-14 1.
Недостатком данного способа вл етс низкий выход целевого продукта. 5 Наиболее близким к предлагаемому по технической сущности и достигаемому результату решением вл етс способ превращени диенового кетона С н,пО в соответствующий насыщенный 10 кетон методом каталитического восстановлени в присутствии PdCl, и активированного угл в среде метилового спирта при 20-22°С и избыточном давлении 60 см вод.столба с выходом ,5 89,5 2.The disadvantage of this method is the low yield of the target product. 5 The closest to the proposed technical essence and the achieved result is a method of converting diene ketone C n, pO into the corresponding saturated 10 ketone by catalytic reduction in the presence of PdCl, and activated carbon in methyl alcohol at 20-22 ° C and overpressure 60 cm water column with exit, 5 89.5 2.
Недостатком каталитического способа вл етс применение дорогого катализ тора , введение водорода в реактор извне, проведение процесса при 20 60 см вод.столба в органическом растворителе (метаноле), вследствие чего конечный продукт приходитс выдел ть перегонкой.The disadvantage of the catalytic method is the use of an expensive catalyst, the introduction of hydrogen into the reactor from the outside, carrying out the process at 20–60 cm of a water column in an organic solvent (methanol), as a result of which the final product must be isolated by distillation.
Цель изобретени - упрощение и 25 интенсификаци процесса.The purpose of the invention is to simplify and intensify the process.
Claims (1)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SU782623812A SU789489A1 (en) | 1978-06-01 | 1978-06-01 | Method of preparing 6,10,14-trimethylpentadecanone-2 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SU782623812A SU789489A1 (en) | 1978-06-01 | 1978-06-01 | Method of preparing 6,10,14-trimethylpentadecanone-2 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SU789489A1 true SU789489A1 (en) | 1980-12-23 |
Family
ID=20768106
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SU782623812A SU789489A1 (en) | 1978-06-01 | 1978-06-01 | Method of preparing 6,10,14-trimethylpentadecanone-2 |
Country Status (1)
| Country | Link |
|---|---|
| SU (1) | SU789489A1 (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5132464A (en) * | 1987-06-16 | 1992-07-21 | Hoffmann-La Roche, Inc. | Hydrogenation process |
-
1978
- 1978-06-01 SU SU782623812A patent/SU789489A1/en active
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5132464A (en) * | 1987-06-16 | 1992-07-21 | Hoffmann-La Roche, Inc. | Hydrogenation process |
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