SU447408A1 - Method for preparing β-phosphorylated 1,3,2-oxazaphospholanes or phosphorinans - Google Patents
Method for preparing β-phosphorylated 1,3,2-oxazaphospholanes or phosphorinansInfo
- Publication number
- SU447408A1 SU447408A1 SU731924266A SU1924266A SU447408A1 SU 447408 A1 SU447408 A1 SU 447408A1 SU 731924266 A SU731924266 A SU 731924266A SU 1924266 A SU1924266 A SU 1924266A SU 447408 A1 SU447408 A1 SU 447408A1
- Authority
- SU
- USSR - Soviet Union
- Prior art keywords
- oxazaphospholanes
- phosphorinans
- phosphorylated
- preparing
- dialkylamino
- Prior art date
Links
Description
1one
Изобретение относитс к фосфороргани-| ческой химии, а именно к способам получени п ти- или шестичленных гетероциклических производных фосфора, содержащих систему р(У) где атомы фосфора имеют разную координацию, общей формулыThis invention relates to an organophosphorus | chemical methods, namely, methods for producing five- or six-membered heterocyclic phosphorus derivatives containing the system p (V) where the phosphorus atoms have different coordination, of the general formula
N,N,
(,). ,Р-х(,) , Px
где X - алкил, арил, диалкиламиногруппа;where X is alkyl, aryl, dialkylamino;
, R и R - алкил, апкоксш руппа;, tt 2 или 3., R and R - alkyl, apkoxsh rupp ;, tt 2 or 3.
Известен способ получени 2-диалкиламин о- 3-ди- (диалкиламино) фосфино-4,5-бензо-1 ,3,2-оксазафосфоланов взаимо{действием гексаалкилтриаминофосфина с о-аминофенолом в соотнощении 2: 1 соответственно при нагревании желательно доA known method of producing 2-dialkylamino-3-di- (dialkylamino) phosphino-4,5-benzo-1, 3,2-oxazaphospholanes by the mutual action of hexaalkyltriaminophosphine with o-aminophenol in a 2: 1 ratio, respectively, when heated, is preferably
U.20-16OOC.U.20-16OOC.
Однако соединени указанной формулы : I ранее в литературе описаны не были. Способ их по. ученн также вл етс новым. Предлагаемьш соёдинени могут найти применение в качестве промежуточных про-, дуктов дл синтера биологически активных веществ. However, compounds of the formula: I have not been previously described in the literature. The way they are by. scientist is also new. The proposed compounds can be used as intermediate products for the sinter of biologically active substances.
Предлагаемый способ получени N -фос- форилированных 1,3,2-оксазафосфоланов или фосфоринанов заключаетс во взаимодействии или -оксиалкиламиддиалкилфосфорной или алкилфосфоновой кислоты с полным амидом фосфористой кислоты (гексаалкилтриаминофосфином ) или тетраа;шилдиамидом алкил(арил)фосфонистой кислоты при нагревании. Синтез ведут в колбе с нисход щим холодильником с отгонкой ди- алкиламина при, 12О-160°С или в кип щем органическом растворителе, например бензоле. Целевые продукты выдел ют известными приемами. Выходы продуктов составл ют 50-60%. Их строение подтверждено данными элементарного анализа, ИК- и ЯМР спектроскопии.The proposed method for the preparation of N -phosphorylated 1,3,2-oxazaphospholanes or phosphorinans consists in the interaction of either α-oxyalkylamiddialkylphosphoric or alkylphosphonic acid with complete phosphorous amide (hexaalkyltriaminophosphine) or tetraa; Synthesis is carried out in a flask with a descending condenser with dialkylamine distillation at, 12O-160 ° C or in a boiling organic solvent, for example, benzene. Target products are recovered by known techniques. Product yields are 50-60%. Their structure is confirmed by the data of elementary analysis, IR and NMR spectroscopy.
. В спектрах ЯMP() соединений. In the spectra of NMR () compounds
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SU731924266A SU447408A1 (en) | 1973-05-24 | 1973-05-24 | Method for preparing β-phosphorylated 1,3,2-oxazaphospholanes or phosphorinans |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SU731924266A SU447408A1 (en) | 1973-05-24 | 1973-05-24 | Method for preparing β-phosphorylated 1,3,2-oxazaphospholanes or phosphorinans |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SU447408A1 true SU447408A1 (en) | 1974-10-25 |
Family
ID=20554301
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SU731924266A SU447408A1 (en) | 1973-05-24 | 1973-05-24 | Method for preparing β-phosphorylated 1,3,2-oxazaphospholanes or phosphorinans |
Country Status (1)
| Country | Link |
|---|---|
| SU (1) | SU447408A1 (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0006220A1 (en) * | 1978-06-19 | 1980-01-09 | Hoechst Aktiengesellschaft | Process for the preparation of 3-Acyl-2-alkyl(aryl)-1.3.2-benzoxazaphospholanes |
-
1973
- 1973-05-24 SU SU731924266A patent/SU447408A1/en active
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0006220A1 (en) * | 1978-06-19 | 1980-01-09 | Hoechst Aktiengesellschaft | Process for the preparation of 3-Acyl-2-alkyl(aryl)-1.3.2-benzoxazaphospholanes |
| US4263231A (en) * | 1978-06-19 | 1981-04-21 | Hoechst Aktiengesellschaft | Process for the manufacture of 3-acyl-2-alkyl- and 3-acyl-2-aryl-1,3,2-benzoxazaphospholanes |
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