SU403409A1 - METHOD OF GETTING SAPARAL12 - Google Patents

Description

The invention relates to medicine, more specifically to the isolation of medicinal irenarates from vegetable raw materials, and concerns a method for producing saparal.

A known method of obtaining Saharal by extracting shredded dried Roots of Aralia with Manchu alcohol, treating the solution with an organic solvent, precipitating the sanonin, filtering and drying.

This method is relatively complicated, associated with large losses of the drug and does not allow to obtain a target of sufficiently high quality.

The aim of the invention is to increase the yield of the target product and simplify its production technology.

This is achieved by the fact that the raw material is subjected to forextraction with chloroform, and after the alcoholic extract is treated with an organic solvent, the precipitate is dissolved in methanol, treated with ethyl acetate and then carried out using known methods.

Example. 1 kg of ground air-dried raw material is placed in an extractor with reflux condenser, 10 l of chloroform is added and boiled for 2 hours in a water bath. Chloroform is distilled off, and the defatted feedstock is extracted with methanol (1: 7) during quenching for 1 hour. The extraction is repeated 5 times, with the last portion of the extract used for fresh

portions of the raw material. The combined extract is evaporated to dryness in vacuo, the residue is dissolved in 1 l of distilled water, acidified with 2N. with a solution of hydrochloric acid to pH 4 at a temperature not exceeding 20 ° C, it is extracted three times with 5-10 mln n-butanol (250 ml each), water-saturated. The butanol extracts are combined, neutralized with ammonia to a pH of 7-8, and they are vacuumized at vacuum.

not higher than 80 ° С to dryness. The residue is dissolved in 300 ml of methanol and 1.5 liters of ethyl acetate are added vigorously stirred. The precipitated saponins are filtered off, washed with 200 ml of ethyl acetate and dried at 60-70 ° C. Yield - 70 g.

Subject invention

The method of obtaining saparala by extracting the ground dried aralia roots with Manchurian soil, treating the solution with an organic solvent, precipitating the sanonin, filtering and drying, characterized in that, in order to increase the yield of the target product and to improve the production technology, the raw material is forged with chloroform, after processing the alcoholic extract with organic the solvent is dissolved in methanol, ethyl acetate is added, followed by treatment in a known manner.