SU365360A1 - METHOD OF OBTAINING 5-SUBSTITUTED 2 ETOXI-2-OXO-3-ETHYL-2-FOSFAOKSAZOZOLIDIN-4-ONOV - Google Patents

Description

one

The invention is related to the production of phosphorus-containing heterocyclic clos, and to the production method of iova.x 5-mixtures, 2-ethoxy-2-oxo-3-ethyl-2-phosphaoxazolidin-4-oov of the general formula

and

21st

C H O-P-NC

I xC Oh

°

R.

where R is acetyl or feil.

These compounds can be used as moon products of electronic orthorhapic synthesis.

Method for preparing 5-substituted 2-ztoxn-2-oxo-3-et11l-2-phosphaoxazolidin-4-ones is based on the fact that ethyl ester is i-ketocaroxy6oiioBoi

RCOCOOCoHs

Where t is acetyl pl or feiil, and expose the interaction with nzoniatom diethylphosphoric acid. 1M.

The process is conducted in an inert organic solvent, such as methylene chloride. Reagites are mixed at a temperature of about -5 ° C, and then the reaction mixture is os2

shtok at komiattavl stand in

current te.myeratu x

Target products are known iriemamn. Yield 51-65%. The compounds are viscous liquids soluble in organic solvents.

Example 1. Preparation of 2-ethoxy-2-oxo-o-ethyl-5-fe11nl-5-carbethoxy-2-fofafoxazolidip-4-one.

To 7.90 g of dithiylphosphoric acid nsocyanate in 10 l / l of methylene chloride, 8.62 g of benzoyl formic acid ethyl ester in 5 ml of metphenyl chloride are ericated with methylene chloride at a temperature of. The reaction mixture is left to stand for a day during the day. As a result of vacuum stripping and bristling 8.41 g of 2-ethoxy-2-oxo-3-ethyl-b-feiyl-5-carbethoxy-2-phosphaoxazolidium-4-oia

(51%,

120-122 ° C / 10

mm Hg St:

t.

0

, 0892; / g, 5055.

4.15; C, 52.81;

11a1 deio, p 10.16; H 6.03. CisnauOfiNP.

X 4,105; C 52.79;

,

P 9.99; P 5.86.

Mol weight (ia | 1deio) 317. Mol. weight. (vychio .leiio) 341.

The design of the current product is confirmed by PC-spectra.

Example 2. Get 2-ethoxy-2-ox-and-et is 1L-5-acet11l-5-carbetho1CC11 - 2 - phos (}) aoxazo. Hg1D1111-4-one.

To 0.54 t jrii.iOiUHO v (|) ii |) a a, r-dik -yumag, iiiiioii KiicJJOTi.i and -I .Lt L1st11; km1x, 10p11da iiiMiKapyvayut 4.01 g of isocyanate of an acid phosphorous acid in 4 ml methylene chloride at a temperature of about-5 ° C. The reaction mixture was allowed to stand at room temperature for 24 hours. As a result of a vacuum; Hopcn obtained 4.93 g of 2-ethoxn-2-oxo-3-et11l-5-anethmyl-5-ka 5-ethoxy-2-phospha () xal () lnd | 1n-4-opa (65%).

T. knn. 115 117 ° C / 1 (1- .I / .U iir. IT .; rt.,

1.4510. R

%:

10.22; X 4.37; WITH

R 10.09; N 4.56; C 42.99;

%:

(found) 304. Mol. weight (calculated structure of the obtained product podBer kdeno IR-hectral1.

P) e dLetnz found and SpSgooo nodlchennm iJ substitute 1. hnni 2 JTOK111-2- () Kso-3 - / 1; | l-2- (ho1ch | 1aoxa.cho1ND1N; -4- onov ooHUi; (|) op.mu, P) 1

About SaNZ

R (: ooc2ii5

| de 1 aigne. n.sh (jjciiii.i, og.p / chinchtsp.ch so that uchi; k) ether with.-ke10 arG) oiovo | | ACID) formula

RCOCOOCal-Ia

Where R has a sazai higher value, the exponential solution with diethylphosphoric acid iodine in an inert organic solvent with the subsequent selection of the target product with known nepiemes is transferred to an annual basis.