SU241447A1 - METHOD OF OBTAINING N- (p-OKCIETHYL) 3,5-DIMETHYL-PYRAZOL - Google Patents
METHOD OF OBTAINING N- (p-OKCIETHYL) 3,5-DIMETHYL-PYRAZOLInfo
- Publication number
- SU241447A1 SU241447A1 SU1226806A SU1226806A SU241447A1 SU 241447 A1 SU241447 A1 SU 241447A1 SU 1226806 A SU1226806 A SU 1226806A SU 1226806 A SU1226806 A SU 1226806A SU 241447 A1 SU241447 A1 SU 241447A1
- Authority
- SU
- USSR - Soviet Union
- Prior art keywords
- obtaining
- okciethyl
- pyrazol
- dimethyl
- dimethylpyrazole
- Prior art date
Links
- WGEUSFXLHJRECP-UHFFFAOYSA-N 2-(2,4-dichlorophenoxy)-1-(3,5-dimethylpyrazol-1-yl)ethanone Chemical compound N1=C(C)C=C(C)N1C(=O)COC1=CC=C(Cl)C=C1Cl WGEUSFXLHJRECP-UHFFFAOYSA-N 0.000 title 1
- IAYPIBMASNFSPL-UHFFFAOYSA-N oxane Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- SDXAWLJRERMRKF-UHFFFAOYSA-N 3,5-dimethyl-1H-pyrazole Chemical compound CC=1C=C(C)NN=1 SDXAWLJRERMRKF-UHFFFAOYSA-N 0.000 description 3
- 239000003708 ampul Substances 0.000 description 2
- VLKZOEOYAKHREP-UHFFFAOYSA-N hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 2
- 238000002955 isolation Methods 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 238000003786 synthesis reaction Methods 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 239000008079 hexane Substances 0.000 description 1
- 239000011541 reaction mixture Substances 0.000 description 1
- 230000002194 synthesizing Effects 0.000 description 1
Description
Изобретение относитс к области получени соединений, которые могут найти применение в органическом синтезе.The invention relates to the field of the preparation of compounds that can be used in organic synthesis.
Предложен способ получени N-(p-OKCHэтил )-3,5-диметилпиразола, заключающийс в том, что 3,5-диметилпиразол подвергают взаимодействию с окисью этилена в присутствии воды при температуре 95-100°С с последующим выделением полученного продукта известным способом.A method is proposed for the preparation of N- (p-OKCH ethyl) -3,5-dimethylpyrazole, consisting in that 3,5-dimethylpyrazole is reacted with ethylene oxide in the presence of water at a temperature of 95-100 ° C, followed by isolation of the resulting product in a known manner.
Пример. Синтез Ы-(р-оксиэтил)-3,5-диметилпиразола из окиси этилена. В толстостенную стекл нную ампулу помещают 9,6 г (0,1 моль) 3,5-диметилпиразола, 4,4 е (0,1 моль) окиси этилена и 1 мл воды. Запа нную ампулу нагревают на кип щей вод ной бане в течение 10-12 час, после чего реакционную смесь перегон ют в вакууме. Получают 11,2 г (выход 85,7% от теоретического) продукта.Example. Synthesis of N- (p-hydroxyethyl) -3,5-dimethylpyrazole from ethylene oxide. 9.6 g (0.1 mol) of 3,5-dimethylpyrazole, 4.4 e (0.1 mol) of ethylene oxide and 1 ml of water are placed in a thick-walled glass ampoule. The sealed ampoule is heated in a boiling water bath for 10-12 hours, after which the reaction mixture is distilled in vacuum. 11.2 g (yield 85.7% of theoretical) of product are obtained.
-(Р-ОКСИЭТИЛ)-3,5-диметилпиразола с т. кип. 118-122°С при 10 мм рт. ст., который при сто нии кристаллизуетс ; т. пл. 69-70°С (из гексана).- (R-OXIETHYL) -3,5-dimethylpyrazole with m. Bale. 118-122 ° C at 10 mm Hg. Art., which crystallizes on standing; m.p. 69-70 ° C (from hexane).
Найдено, %: N 19,94; 20,16.Found,%: N 19.94; 20.16.
CTHiaONs.Cthiaons
Вычислено, %: N 19,97.Calculated,%: N 19.97.
Предмет изобретени Subject invention
Способ получени Ы-(р-оксиэтил)-3,5-диметилппразола , отличающийс тем, что 3,5-диметилпиразол подвергают взаимодействию с окисью этилена в присутствии воды при температуре 95-100°С с последующим выделением полученного продукта известным способом.The method of obtaining N- (p-hydroxyethyl) -3,5-dimethylprazole, characterized in that 3,5-dimethylpyrazole is reacted with ethylene oxide in the presence of water at a temperature of 95-100 ° C, followed by isolation of the resulting product in a known manner.
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SU241447A1 true SU241447A1 (en) |
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