SU222266A1 - METHOD FOR PREPARING DIFEPHYLMANE DIGUPEHYLPRASONES - Google Patents
METHOD FOR PREPARING DIFEPHYLMANE DIGUPEHYLPRASONESInfo
- Publication number
- SU222266A1 SU222266A1 SU1114641A SU1114641A SU222266A1 SU 222266 A1 SU222266 A1 SU 222266A1 SU 1114641 A SU1114641 A SU 1114641A SU 1114641 A SU1114641 A SU 1114641A SU 222266 A1 SU222266 A1 SU 222266A1
- Authority
- SU
- USSR - Soviet Union
- Prior art keywords
- digupehylprasones
- difephylmane
- preparing
- methane ethane
- sulfonic
- Prior art date
Links
- MEKDPHXPVMKCON-UHFFFAOYSA-N ethane;methane Chemical compound C.CC MEKDPHXPVMKCON-UHFFFAOYSA-N 0.000 description 5
- -1 proponyl Chemical group 0.000 description 3
- 150000003839 salts Chemical class 0.000 description 3
- 239000011780 sodium chloride Substances 0.000 description 3
- 150000001875 compounds Chemical class 0.000 description 2
- YXFVVABEGXRONW-UHFFFAOYSA-N toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 2
- 235000014647 Lens culinaris subsp culinaris Nutrition 0.000 description 1
- 244000043158 Lens esculenta Species 0.000 description 1
- YGSDEFSMJLZEOE-UHFFFAOYSA-N Salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 description 1
- HVBSAKJJOYLTQU-UHFFFAOYSA-N Sulfanilic acid Chemical compound NC1=CC=C(S(O)(=O)=O)C=C1 HVBSAKJJOYLTQU-UHFFFAOYSA-N 0.000 description 1
- 125000000218 acetic acid group Chemical group C(C)(=O)* 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 229920002892 amber Polymers 0.000 description 1
- HAMNKKUPIHEESI-UHFFFAOYSA-N aminoguanidine Chemical compound NNC(N)=N HAMNKKUPIHEESI-UHFFFAOYSA-N 0.000 description 1
- 125000003118 aryl group Chemical group 0.000 description 1
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid group Chemical group C(C1=CC=CC=C1)(=O)O WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 1
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 125000004063 butyryl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 125000001589 carboacyl group Chemical group 0.000 description 1
- 125000004432 carbon atoms Chemical group C* 0.000 description 1
- 235000013365 dairy product Nutrition 0.000 description 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
- LYCAIKOWRPUZTN-UHFFFAOYSA-N glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 1
- 150000005171 halobenzenes Chemical class 0.000 description 1
- UWYVPFMHMJIBHE-OWOJBTEDSA-N hydroxymaleic acid group Chemical group O/C(/C(=O)O)=C/C(=O)O UWYVPFMHMJIBHE-OWOJBTEDSA-N 0.000 description 1
- UQSXHKLRYXJYBZ-UHFFFAOYSA-N iron oxide Chemical class [Fe]=O UQSXHKLRYXJYBZ-UHFFFAOYSA-N 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 150000007522 mineralic acids Chemical class 0.000 description 1
- PSZYNBSKGUBXEH-UHFFFAOYSA-N naphthalene-1-sulfonic acid Chemical compound C1=CC=C2C(S(=O)(=O)O)=CC=CC2=C1 PSZYNBSKGUBXEH-UHFFFAOYSA-N 0.000 description 1
- GRYLNZFGIOXLOG-UHFFFAOYSA-N nitric acid Chemical class O[N+]([O-])=O GRYLNZFGIOXLOG-UHFFFAOYSA-N 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 235000005985 organic acids Nutrition 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 229950000244 sulfanilic acid Drugs 0.000 description 1
- 150000003460 sulfonic acids Chemical class 0.000 description 1
Description
Предлагаетс способ получени дигуанилгидразопов дифенилмочевины общей формулыA method is proposed for the preparation of diphenylureasophenyl diphenylureas of the general formula
илп его солью, с последующим выделенпем продукта известным способом.or its salt, followed by isolation of the product in a known manner.
или их солей, где R - низший алкильный радикал , преимущественно метиловый, этиловый, бутиловый, лентиловый. Полученные соединени обладают физиологически активными свойствами. Способ состоит в том, что соединение общейor their salts, where R is a lower alkyl radical, mainly methyl, ethyl, butyl, lentil. The resulting compounds have physiologically active properties. The method is that the compound is common
фор мул 1)1formula 1) 1
X -/ VNH-C -зчш X - / VNH-C - shch
- IIv.- IIv.
или его реакционноснособные оксоиронзводные , где X - низшие алканоильные остатки, с минимум двум атомами углерода, например ацетил, проппонил, бутирил, оэнантоил, подвергают взаимодействию с гуанилгидразиномor its reactive oxoiron derivatives, where X is lower alkanoyl residues with at least two carbon atoms, for example acetyl, proponyl, butyryl, oenantoyl, are reacted with guanylhydrazine
В зависимост от услови) реакции и исходных веществ конечные продукты получают в чистом виде или в форме их солей неорганических и органических кислот таких, как: галогеноводородные , серные, фосфорные, азотные кислоты; алн1|)ат11ческие, алициклоические, ароматические или гетероциклические карбоновые либо сульфоновые кислоты, например муравьина , уксусна , проиионова , нтарна ,Depending on the condition of the reaction and the starting materials, the final products are obtained in pure form or in the form of their salts of inorganic and organic acids, such as: hydrohalic, sulfuric, phosphoric, nitric acids; aln1 |) atric, alicyclo, aromatic or heterocyclic carboxylic or sulfonic acids, for example formic, acetic, propionic, amber,
гликолева , молочна , блочна , винна , лимонна , аскорбинова , малеинова , гидроксималеинова , пировиноградна , фенилуксусна , бензойна , к-аминобензойна , антранилова , /г-гидроксибензойна , салицилова или к-аминосалицилова , а также метан-этан-, гидроксиэтан- , зтиленсульфонова кислота; галогенбензол сульфоновые, толуолсульфоновые,. нафталинсульфоновые кислоты или сульфанилова кислота.glycol, dairy, block, vinna, citric, ascorbic, maleic, hydroxymaleic, pyruvic, phenylacetic, benzoic, k-aminobenzoic, anthraniline, / g-hydroxybenzoic, salicylic or k-aminosalicylic, methane ethane, and methane ethane, and methane ethane, and methane ethane, and methane ethane; acid; halobenzene sulfonic, toluene sulfonic ,. naphthalenesulfonic acid or sulfanilic acid.
HaN-C -NH VjiH-C -NH -/ Vc К-№1-С- дН. I I, IIIHaN-C -NH VjiH-C -NH - / Vc K-No. 1-C-dN. I I, III
- NHRQВNH- NHRQBNH
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SU222266A1 true SU222266A1 (en) |
Family
ID=
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5750573A (en) * | 1994-01-21 | 1998-05-12 | The Picower Institute For Medical Research | Guanylhydrazones and their use to treat inflammatory conditions |
| US6008255A (en) * | 1994-01-21 | 1999-12-28 | The Picower Institute For Medical Research | Guanylhydrazones and their use to treat inflammatory conditions |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5750573A (en) * | 1994-01-21 | 1998-05-12 | The Picower Institute For Medical Research | Guanylhydrazones and their use to treat inflammatory conditions |
| US5859062A (en) * | 1994-01-21 | 1999-01-12 | The Picower Institute For Medical Research | Guanylhydrazones and their use to treat inflammatory conditions |
| US6008255A (en) * | 1994-01-21 | 1999-12-28 | The Picower Institute For Medical Research | Guanylhydrazones and their use to treat inflammatory conditions |
| US6022900A (en) * | 1994-01-21 | 2000-02-08 | The Picower Institute For Medical Research | Guanylhydrazones and their use to treat inflammatory conditions |
| US6180676B1 (en) | 1994-01-21 | 2001-01-30 | The Picower Institute For Medical Research | Guanylhydrazones and their use to treat inflammatory conditions |
| US6248787B1 (en) | 1994-01-21 | 2001-06-19 | The Picower Institute For Medical Research | Guanylhydrazones and their use to treat inflammatory conditions |
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