SU1518736A1 - Method of quantitative determination of trioxymethylaminomethane - Google Patents
Method of quantitative determination of trioxymethylaminomethane Download PDFInfo
- Publication number
- SU1518736A1 SU1518736A1 SU874328313A SU4328313A SU1518736A1 SU 1518736 A1 SU1518736 A1 SU 1518736A1 SU 874328313 A SU874328313 A SU 874328313A SU 4328313 A SU4328313 A SU 4328313A SU 1518736 A1 SU1518736 A1 SU 1518736A1
- Authority
- SU
- USSR - Soviet Union
- Prior art keywords
- solution
- ban
- quantitative determination
- trioxymethylaminomethane
- naphthoquinone
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims description 8
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 claims abstract description 18
- SVPKNMBRVBMTLB-UHFFFAOYSA-N 2,3-dichloronaphthalene-1,4-dione Chemical compound C1=CC=C2C(=O)C(Cl)=C(Cl)C(=O)C2=C1 SVPKNMBRVBMTLB-UHFFFAOYSA-N 0.000 claims abstract description 5
- 239000003153 chemical reaction reagent Substances 0.000 claims abstract description 3
- 239000012491 analyte Substances 0.000 claims abstract 2
- 239000000243 solution Substances 0.000 claims description 14
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 8
- -1 1, 2-Naphthoquinone Aliphatic amines Chemical class 0.000 claims description 3
- 239000012153 distilled water Substances 0.000 claims description 3
- 239000000126 substance Substances 0.000 claims description 3
- 238000009835 boiling Methods 0.000 claims description 2
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims 3
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims 2
- JXLHNMVSKXFWAO-UHFFFAOYSA-N azane;7-fluoro-2,1,3-benzoxadiazole-4-sulfonic acid Chemical compound N.OS(=O)(=O)C1=CC=C(F)C2=NON=C12 JXLHNMVSKXFWAO-UHFFFAOYSA-N 0.000 claims 2
- 229940105324 1,2-naphthoquinone Drugs 0.000 claims 1
- BTBUEUYNUDRHOZ-UHFFFAOYSA-N Borate Chemical compound [O-]B([O-])[O-] BTBUEUYNUDRHOZ-UHFFFAOYSA-N 0.000 claims 1
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 claims 1
- 240000006240 Linum usitatissimum Species 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 150000004982 aromatic amines Chemical class 0.000 claims 1
- 239000007853 buffer solution Substances 0.000 claims 1
- 239000008098 formaldehyde solution Substances 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 238000005375 photometry Methods 0.000 claims 1
- 150000003139 primary aliphatic amines Chemical class 0.000 claims 1
- AKHNMLFCWUSKQB-UHFFFAOYSA-L sodium thiosulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=S AKHNMLFCWUSKQB-UHFFFAOYSA-L 0.000 claims 1
- 235000019345 sodium thiosulphate Nutrition 0.000 claims 1
- DAJSVUQLFFJUSX-UHFFFAOYSA-M sodium;dodecane-1-sulfonate Chemical compound [Na+].CCCCCCCCCCCCS([O-])(=O)=O DAJSVUQLFFJUSX-UHFFFAOYSA-M 0.000 claims 1
- 229940124530 sulfonamide Drugs 0.000 claims 1
- 150000003456 sulfonamides Chemical class 0.000 claims 1
- 239000003643 water by type Substances 0.000 claims 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 6
- 229960000281 trometamol Drugs 0.000 description 6
- 230000003287 optical effect Effects 0.000 description 3
- 239000000203 mixture Substances 0.000 description 2
- 208000010444 Acidosis Diseases 0.000 description 1
- 230000007950 acidosis Effects 0.000 description 1
- 208000026545 acidosis disease Diseases 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 239000012086 standard solution Substances 0.000 description 1
Landscapes
- Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
Abstract
Изобретение касаетс аналитической химии, в частности количественного определени триоксиметиламинометана, и может быть использовано дл анализа в аптеках и фармацевтическом производстве. Цель - повышение селективности и упрощение анализа, его ведут обработкой диметилформамидного раствора определ емого вещества, 2,3 -дихлорнафтохиноном-1,4 при нагревании с последующим фотоколориметрованием полученного окрашенного раствора. Эти услови значительно сокращают число используемых реагентов и операций, снижают продолжительность анализа с 40-60 мин до 10-15 мин (в 4 раза). 3 табл.The invention relates to analytical chemistry, in particular the quantitative determination of trioxymethylaminomethane, and can be used for analysis in pharmacies and pharmaceutical production. The goal is to increase the selectivity and simplify the analysis, it is treated with a dimethylformamide solution of the analyte, 2,3-dichloro-naphthoquinone-1,4 when heated, followed by photocolorimetry of the resulting colored solution. These conditions significantly reduce the number of reagents and operations used, reduce the duration of the analysis from 40-60 minutes to 10-15 minutes (4 times). 3 tab.
Description
Изобретение относитс к аналитической химии, а именно к способам количественного определени триокси- метиламинометана, примен емого в медицинской практике при ацидозах.The invention relates to analytical chemistry, in particular to methods for the quantitative determination of trioxymethylaminomethane, used in medical practice in acidosis.
Цель изобретени - повышение селективности и упрощение способа.The purpose of the invention is to increase the selectivity and simplify the method.
Пример. Количественное определение трисамина в субстанции. Точную навеску препарата в пределах 0,0375-0,0625 г раствор ют в 5 мл дистиллированной воды в мерной колбе вместимостью 50 мл и довод т диметил- формамидом до метки. 2 мл полученного раствора обрабатывают 2 мл 1%-но- го раствора 2,3-дихлорнафтохи1юна в диметилформамиде и нагревают в течение 5 мин на кип щей вод ной бане. После охлаждени раствор перенос тExample. Quantitative determination of trisamine in substance. The exact weight of the preparation in the range of 0.0375-0.0625 g is dissolved in 5 ml of distilled water in a 50 ml volumetric flask and adjusted to the mark with dimethylformamide. 2 ml of the resulting solution is treated with 2 ml of a 1% solution of 2,3-dichloro-naphthoxychion in dimethylformamide and heated for 5 minutes in a boiling water bath. After cooling, the solution is transferred
в мерную колбу вместимостью 25 мл, довод т диметилформамидом до метки, тщательно перемешива .. Параллельно провод т опыт со стандартным раствором трисамина и раствором - фоном.into a volumetric flask with a capacity of 25 ml, bring to the mark with dimethylformamide, mix thoroughly. In parallel, conduct an experiment with a standard trisamine solution and a solution - background.
Измер ют оптическую плотность анализируемых растворов на фоне контрол при помощи спектрофотометра при нм в кюветах с тол1циной сло 1 см.The optical density of the analyzed solutions was measured against the control using a spectrophotometer at nm in cuvettes with a thickness of 1 cm.
Расчет количественного содержани трисамина провод т по формулеThe calculation of the amount of trisamine is carried out according to the formula
СПSP
0000
со Одwith od
С % WITH %
Co-D-50-25 5 р 2Co-D-50-25 5 p 2
где D - оптическа плотность анализируемого раствора при мс(кс +90 нм;where D is the optical density of the analyzed solution at ms (ks +90 nm;
TVTv
31513151
оптическа плотность стандартного раствора; С(, - концентраци стандартного спектрофотометрируемого раствора (0,ОП80 г в 100 мл); р - навеска, г.optical density of the standard solution; C (, is the concentration of a standard spectrophotometric solution (0, OP80 g in 100 ml); p — weight,
Результаты количественного определени трисамина в субстанции приведены в табл. 1.The results of the quantitative determination of trisamine in the substance are given in Table. one.
П р и м е р 2. Количественное определение трисамина в 3, растворе . 2 мл раствора помещают в мерную колбу вместимостью 50 мл, добавл ют 3 л дистиллированной воды и довод т до метки диметилформамидом. Из ра - ведени берут 2 мл раствора, обрабатывают 2 мл 1%-ного раствора 2,3-ди- хлорнафтохинона и дальнейшее определение провод т как описано в примере 1 .PRI mme R 2. Quantitative determination of trisamine in 3, solution. 2 ml of the solution is placed in a 50 ml measuring flask, 3 l of distilled water is added and the mixture is made up to the mark with dimethylformamide. From the study, 2 ml of the solution is taken, treated with 2 ml of a 1% solution of 2,3-dichloro-naphthoquinone, and further determination is carried out as described in Example 1.
Результаты количественного определени трисамина в 3,66%-ном растворе приведены в табл. 2,The results of the quantitative determination of trisamine in the 3.66% solution are given in table. 2,
Сравнительна характеристика предлагаемого способа с известным представлена в табл. 3.Comparative characteristics of the proposed method with the well-known are presented in table. 3
Таким образом, предлагаемый способ повышает селективность определени , так как с дихлоном реагируют только алифатические амины, сокращает продолжительность анализа в 4 раза при сохранении высокой чувствительности . Кроме того, способ более прост в выполнении за счет сокращени числа реагентов и операций.Thus, the proposed method increases the selectivity of the determination, since only aliphatic amines react with the dichlone, reduces the duration of the analysis by 4 times while maintaining high sensitivity. Furthermore, the method is more simple to perform by reducing the number of reagents and operations.
R736R736
Claims (1)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SU874328313A SU1518736A1 (en) | 1987-11-17 | 1987-11-17 | Method of quantitative determination of trioxymethylaminomethane |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SU874328313A SU1518736A1 (en) | 1987-11-17 | 1987-11-17 | Method of quantitative determination of trioxymethylaminomethane |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SU1518736A1 true SU1518736A1 (en) | 1989-10-30 |
Family
ID=21336337
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SU874328313A SU1518736A1 (en) | 1987-11-17 | 1987-11-17 | Method of quantitative determination of trioxymethylaminomethane |
Country Status (1)
| Country | Link |
|---|---|
| SU (1) | SU1518736A1 (en) |
-
1987
- 1987-11-17 SU SU874328313A patent/SU1518736A1/en active
Non-Patent Citations (1)
| Title |
|---|
| Сиггиа С., Ханна Дж.Г. Количественный органический анализ по функциональным группам. М.: Хими , 1983, с. 482-86. * |
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