SU1410983A1 - Method of treatment of otosclerosis - Google Patents

Abstract

The invention relates to medicine, more specifically to otolaryngology. The purpose of the invention is to improve the bone and air conduction and reduce the complications of fluorotherapy. For this, the patient is treated with sodium fluoride (but 0.5-1.0. Mg / kg per day for 1.5-2 months) and at the same time prescribed dimephosphone (but 100 mg / kg per day for 7 days) at the beginning and end of the course.

Description

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This invention relates to medicine, in particular to otolaryngology.

The purpose of the invention is to improve the bone and air conduction and reduce the complications of fluorotherapy.

Example 1. Patient 3., 32 years old, came to the ENT clinic on 10.09.84 with complaints of progressive hearing loss and low-frequency tinnitus for 7 years. Otoscopy did not reveal the visual pathology of the ears.

Hearing test: whisper speech AD О m, AS 2 m, spoken AD 2 m, AS .more than 6 m. When audiometry, the average thresholds of air conduction at frequencies of 125-2000 HZ AO 53 dB, AS 41 dB, bone conduction at frequencies of 500 - 8000 Hz AD 12 dB, AS 12 dB. With noise measurement, the average noise thresholds AD are 9.3 dB, AS 11.3 dB.

The patient was prescribed sodium fluoride at a dose of 0.5 mg / kg per day for 2 months orally and dimephosphone at 100. Mg / kg per day for 7 days at the beginning and end of the course. Complications of fluorotherapy were not.

Patient after treatment noted u.men

hearing shu.ma in ears, hearing remained unchanged

him level. Shelp speech AD About m, AS 1.5. M, spoken speech AD 1 m, AS over 6 m. With audio metrics, the average airborne sound thresholds AD are 55 dB, AS is 42 dB, bone sound is AD 1 I dB, AS 11 dB . When noise metering the average noise thresholds. 2.1 dB, .AS 2.8 dB, i.e. decreased significantly.

and operations 12/12/84, a white sclerotic lesion was detected, unblown at. manipulation. Histological examination of the lesion revealed an inactive stage of the otosclerotic process. Perilymph proteinase activity was normal (0.21 mmol-arg / s-l).

At follow-up examination of July 1, 1985, hearing on the operated ear was good, and there was no tinnitus. Hearing test: whisper speech AD more than 6 m, AS 3 m, spoken AD more than 6 m, AS more than 6 m. When audiometry, the airborne sound thresholds. AD 16 dB, AS 46 dB, bone marrow sound AD 11 dB, AS 14 db

Example 2. Ill, 27 years old, came to the ENT clinic on 01/20/85 with complaints of progressive hearing loss on both ears and low-frequency noise in the right ear for 3 years. Based on the clinical signs, the stage of otosclerosis is diagnosed.

Hearing test: whisper speech AD About m, AS 0.5 m, spoken AD 0.3 m, AS 1.5 m. When listening audiometry, the average airborne sound thresholds are AD 62 dB, AS 45 dB, and bone sound is AD 18 dB, AS 12 dB When and. The average noise threshold is 15.7 dB.

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The patient received a course of treatment with sodium fluoride and dimephosphone. After treatment, the ear noise decreased, the hearing was slightly reduced in the left ear. No complications of fluorotherapy were noted.

Hearing test: whisper speech AD About m, AS 0.8 m, spoken AD 0.2 m, AS 2 m. When audiometry, the airborne sound thresholds AD 63 dB, AS 51 dB, bone AD 11 dB, AS 12 dB. The noise threshold is reduced to 64 dB.

Pa operation 12.04.85, found dense white color otosclerotic lesion. Histological examination confirmed the inactive nature of the pathological process. The level of nroteinases in perilymph is normal (0.23 mmol-arg / s-l).

During the examination of January 30, 1986, the hearing on the operated ear was good, the ear was gone. Hearing test: whisper speech AD over 6 m, AS 1.5 m, spoken AD over 6 m, AS 2.5 m. With audiometry, the airborne sound thresholds AD 16 dB, AS 51 dB, bone conduction sound AD 10 dB, AS 9 db

Example 3. Sick W., 36 years old, came to the ENT clinic on 4.03.85, complaining of progressive hearing loss and noise in the right ear for 9 years. On the basis of clinical signs, the stage of otosclerosis was diagnosed moderately active.

Hearing test: whisper speech AD About m, AS 5 m, spoken AD 1.7 m, AS more than 6 m. For audiometry, the airborne sound thresholds are AD 45 dB, AS 14 dB, bone AD 11 dB, AS 4 dB. The noise level is 11.4 dB.

The patient received a course of treatment with sodium fluoride and dimephosphone. After treatment, the ear noise decreased, the hearing improved slightly, there were no complications.

Hearing test: whisper speech AD 0.2 m, AS over 6 m, spoken speech AD 1.5 m, AS over 6 m. Thresholds of air conduction AD 44 dB, AS 11 dB, bone conduction AD 11 dB, AS 5 dB. The noise level is reduced to 2.1 dB.

On operation 05/29/85, a white otosclerotic lesion was found. Histological examination revealed an inactive otosclerotic lesion. The protease level of 0.55 mmol. L-arg / s-l was slightly higher than normal (0.41-f0.04 mmol-arg / s-l).

Sick 10.09.85 g. Marked a significant improvement in hearing and the disappearance of noise in the ear. Hearing test: whisper speech AD 6 m, AS over 6 m, spoken AD over 6 m, AS over 6 m. For audiometry, the airborne sound thresholds are AD 9 dB, AS 11 dB, bone conduction AD 8 dB, AS 4 dB.

The treatment of the proposed method, carried out in 25 patients, led to the stabilization of the processes of pathological bone.

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Restructuring and stimulating the formation of but-reduces the complications of long-term fluorocarpal plate bone. Inactivation of the cause due to its toxic effect,

Claims (1)

the sclerotic focus is generated by the Sta-Formula of Invention Bilization of hearing thresholds - the possibility of treating otosclerosis, including airborne sound conduction, significant 5 administration of sodium fluoride, which distinguishes the improvement of bone sound thresholds, in order to improve bone marrow and day, the normalization of the activity of nrotheoly-air conduction and diminutive enzymes in the perilymph and the reduction of complications of fluoroterania, the addition or disappearance of tinnitus. Dimephosphone is introduced at the beginning and at the end. A prolonged course of fluorotherapy is a warning for treatment periods.