SU140168A1 - Dry enteric coating of solid dosage forms - Google Patents
Dry enteric coating of solid dosage formsInfo
- Publication number
- SU140168A1 SU140168A1 SU688190A SU688190A SU140168A1 SU 140168 A1 SU140168 A1 SU 140168A1 SU 688190 A SU688190 A SU 688190A SU 688190 A SU688190 A SU 688190A SU 140168 A1 SU140168 A1 SU 140168A1
- Authority
- SU
- USSR - Soviet Union
- Prior art keywords
- dosage forms
- solid dosage
- enteric coating
- hours
- dry
- Prior art date
Links
Landscapes
- Medicinal Preparation (AREA)
Description
Известные сухие покрыти твердых лекарственных форм, принимаемых внутрь через рот, не имеют достаточной устойчивости в кислой среде желудка и плохо раствор ютс в щелочной среде кишечника.The known dry coatings of solid dosage forms, taken orally through the mouth, do not have sufficient stability in the acidic environment of the stomach and are poorly soluble in the alkaline environment of the intestine.
С целью локализации действи лекарственных веществ в кищечнике , сухое покрытие твердых лекарственных форм предлагаетс изготавливать из молочного сахара - 20 вес. ч., талька - 18 вес. ч., каолина- 20 вес. ч., шоколада - 20 вес. ч., стеарата кальци - 10 вес. ч., стеариновой кислоты - 6 вес. ч., желтого воска - 4 вес. ч. и касторового масла - 2 вес. ч.In order to localize the action of medicinal substances in the kischechnik, a dry coating of solid dosage forms is proposed to be made from milk sugar - 20 wt. hours, talc - 18 wt. h, kaolin, 20 wt. hours, chocolate - 20 wt. hours, calcium stearate - 10 wt. hours, stearic acid - 6 wt. hours, yellow wax - 4 wt. hours and castor oil - 2 wt. h
Все компоненты сухого кишечнорастворимого покрыти дл твердых лекарственных форм должны соответствовать стать м Государственной фармакопеи СССР и соответствующим стандартам.All components of the dry enteric coating for solid dosage forms must comply with the State Pharmacopoeia of the USSR and the relevant standards.
Дл приготовлени сухого кищечнорастворимого покрыти твердых лекарственных форм все порошкообразные компоненты, вход щие в состав покрыти , просеивают через сито с диаметром отверстий 0,25 nut и смешивают в необходимой пропорции. Увлажнение полученной смеси производ т охлажденными до температуры 60° 3%-ным крахмальным клейстером (10 вес. ч.) и расплавом шоколада, желтого воска и касторового масла. Полученную массу гранулируют и сущат при температуре не выше 40°. Покрытие таблеток массой приготовленной указанным способом производ т на таблеточной машине типа Prescoter. Предмет изобретени To prepare a dry, food-soluble coating of solid dosage forms, all the powdered components that make up the coating are sieved through a sieve with a hole diameter of 0.25 nut and mixed in the required proportion. Moistening of the mixture obtained is made cooled to a temperature of 60 ° with 3% starch paste (10 wt. H) and melted chocolate, yellow wax and castor oil. The resulting mass is granulated and grown at a temperature not higher than 40 °. The coating of the tablets with the mass prepared in this way is carried out on a Prescoter type tablet machine. Subject invention
Сухое кишечнорастворимое покрытие твердых лекарственных форм, принимаемых внутрь через рот, отличающеес тем, что, с целью достижени устойчивости лекарственных форм в кислой среде желудка и растворени их в щелочной среде кищечника, оно состоит из сахара молочного - 20 вес. ч., талька - 18 вес. ч., каолина - 20 вес, ч,, щоколада - 20 вес. ч., стеарата кальци - 10 вес. ч., стеариновой кислоты - 6 вес. ч., воска желтого - 4 вес. ч., касторового масла - 2 вес. ч.The dry enteric coating of solid dosage forms, taken orally through the mouth, is characterized in that, in order to achieve the sustainability of the dosage forms in the acidic environment of the stomach and dissolve them in the alkaline environment of the kischer, it consists of milk sugar - 20 wt. hours, talc - 18 wt. h, kaolin - 20 weight, h ,, chocolate - 20 weight. hours, calcium stearate - 10 wt. hours, stearic acid - 6 wt. hours, yellow wax - 4 wt. hours, castor oil - 2 wt. h
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Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SU688190A SU140168A1 (en) | 1960-12-06 | 1960-12-06 | Dry enteric coating of solid dosage forms |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SU688190A SU140168A1 (en) | 1960-12-06 | 1960-12-06 | Dry enteric coating of solid dosage forms |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SU140168A1 true SU140168A1 (en) | 1961-11-30 |
Family
ID=48296197
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SU688190A SU140168A1 (en) | 1960-12-06 | 1960-12-06 | Dry enteric coating of solid dosage forms |
Country Status (1)
| Country | Link |
|---|---|
| SU (1) | SU140168A1 (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4271142A (en) * | 1979-06-18 | 1981-06-02 | Life Savers, Inc. | Portable liquid antacids |
| US4533543A (en) * | 1982-01-22 | 1985-08-06 | Nabisco Brands, Inc. | Soft homogeneous antacid tablet |
| US4581381A (en) * | 1983-11-14 | 1986-04-08 | Nabisco Brands, Inc. | Soft homogeneous antacid tablet |
| US4609543A (en) * | 1983-11-14 | 1986-09-02 | Nabisco Brands, Inc. | Soft homogeneous antacid tablet |
-
1960
- 1960-12-06 SU SU688190A patent/SU140168A1/en active
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4271142A (en) * | 1979-06-18 | 1981-06-02 | Life Savers, Inc. | Portable liquid antacids |
| US4533543A (en) * | 1982-01-22 | 1985-08-06 | Nabisco Brands, Inc. | Soft homogeneous antacid tablet |
| US4581381A (en) * | 1983-11-14 | 1986-04-08 | Nabisco Brands, Inc. | Soft homogeneous antacid tablet |
| US4609543A (en) * | 1983-11-14 | 1986-09-02 | Nabisco Brands, Inc. | Soft homogeneous antacid tablet |
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