SU1331501A1 - Method of obtaining artificial osseous transplants - Google Patents
Method of obtaining artificial osseous transplants Download PDFInfo
- Publication number
- SU1331501A1 SU1331501A1 SU833608246A SU3608246A SU1331501A1 SU 1331501 A1 SU1331501 A1 SU 1331501A1 SU 833608246 A SU833608246 A SU 833608246A SU 3608246 A SU3608246 A SU 3608246A SU 1331501 A1 SU1331501 A1 SU 1331501A1
- Authority
- SU
- USSR - Soviet Union
- Prior art keywords
- mixture
- transplants
- added
- gelatin
- inflammatory properties
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims description 4
- 210000000988 bone and bone Anatomy 0.000 claims abstract description 10
- 239000000203 mixture Substances 0.000 claims abstract description 9
- 230000003110 anti-inflammatory effect Effects 0.000 claims abstract description 5
- 108010010803 Gelatin Proteins 0.000 claims abstract description 4
- 239000003242 anti bacterial agent Substances 0.000 claims abstract description 4
- 229920000159 gelatin Polymers 0.000 claims abstract description 4
- 239000008273 gelatin Substances 0.000 claims abstract description 4
- 235000019322 gelatine Nutrition 0.000 claims abstract description 4
- 235000011852 gelatine desserts Nutrition 0.000 claims abstract description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 4
- 102000008186 Collagen Human genes 0.000 claims abstract description 3
- 108010035532 Collagen Proteins 0.000 claims abstract description 3
- 229920001436 collagen Polymers 0.000 claims abstract description 3
- 229910052588 hydroxylapatite Inorganic materials 0.000 claims abstract description 3
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 claims abstract description 3
- 229910019142 PO4 Inorganic materials 0.000 claims abstract 2
- 229940088710 antibiotic agent Drugs 0.000 claims abstract 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims abstract 2
- 239000010452 phosphate Substances 0.000 claims abstract 2
- 238000002604 ultrasonography Methods 0.000 claims description 3
- 229940124530 sulfonamide Drugs 0.000 claims description 2
- 150000003456 sulfonamides Chemical class 0.000 claims 1
- 230000007547 defect Effects 0.000 abstract description 3
- 239000003814 drug Substances 0.000 abstract description 3
- 150000003839 salts Chemical class 0.000 abstract description 3
- 230000003115 biocidal effect Effects 0.000 description 2
- 229960005091 chloramphenicol Drugs 0.000 description 2
- WIIZWVCIJKGZOK-RKDXNWHRSA-N chloramphenicol Chemical compound ClC(Cl)C(=O)N[C@H](CO)[C@H](O)C1=CC=C([N+]([O-])=O)C=C1 WIIZWVCIJKGZOK-RKDXNWHRSA-N 0.000 description 2
- 229910052500 inorganic mineral Inorganic materials 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 239000011707 mineral Substances 0.000 description 2
- 230000010355 oscillation Effects 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 229910000679 solder Inorganic materials 0.000 description 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 239000004098 Tetracycline Substances 0.000 description 1
- 206010052779 Transplant rejections Diseases 0.000 description 1
- 239000002729 catgut Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 230000002757 inflammatory effect Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 230000005923 long-lasting effect Effects 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 230000000399 orthopedic effect Effects 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- XUGKCAXBCXJYCD-UHFFFAOYSA-N sodium;(4-aminophenyl)sulfonyl-(5-ethyl-1,3,4-thiadiazol-2-yl)azanide Chemical compound [Na+].S1C(CC)=NN=C1[N-]S(=O)(=O)C1=CC=C(N)C=C1 XUGKCAXBCXJYCD-UHFFFAOYSA-N 0.000 description 1
- FDDDEECHVMSUSB-UHFFFAOYSA-N sulfanilamide Chemical compound NC1=CC=C(S(N)(=O)=O)C=C1 FDDDEECHVMSUSB-UHFFFAOYSA-N 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 229960002180 tetracycline Drugs 0.000 description 1
- 229930101283 tetracycline Natural products 0.000 description 1
- 235000019364 tetracycline Nutrition 0.000 description 1
- 150000003522 tetracyclines Chemical class 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
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- Materials For Medical Uses (AREA)
Abstract
Изобретение относитс к медицине и может быть использовано в травматологии дл замещени об11шрньгх костных дефектов. Пель изобретени - предупреждение отторжени путем придани трансплантатам противовоспалительных свойств. Поставленна цель достигаетс путем смешивани соли гидрооксиапатита Са ,о (РО) (OH)j или бетатрикальций фосфата Са . (РО)Н2(OH)j , желатина или коллагена и воды, помещени полученной смеси в форму и воздействи на смесь ультразвуком, причем перед озвучиванием в смесь добавл ют антибиотики и сульфаниламиды. со САЭThe invention relates to medicine and can be used in traumatology for the replacement of ocular bone defects. The invention is designed to prevent rejection by implanting anti-inflammatory properties to the grafts. The goal is achieved by mixing the salt of hydroxyapatite Ca, o (PO) (OH) j, or betaatricalcium phosphate Ca. (PO) H2 (OH) j, gelatin or collagen and water, placing the resulting mixture in a mold and sonicating the mixture, and antibiotics and sulfanilamides are added to the mixture before dubbing. with SAE
Description
11eleven
Изобретение относитс к медицине, более точно к травматологии, и может быть использовано дл замещени обширных костных дефектов.The invention relates to medicine, more specifically to traumatology, and can be used to replace extensive bone defects.
Цель изобретени - предупреждение отторжени трансплантата путем придани ему противовоспалительных свойств.The purpose of the invention is the prevention of graft rejection by imparting anti-inflammatory properties to it.
Способ осуществл ют следующим образом ,The method is carried out as follows.
Берут минеральные соли гидроокси- апатита Са (PO)(OH)j или бета- трикальцийфосфат Сад(РО) Hj(ОН) 60%, желатин или коллаген 30%, воду 10%. К полученной массе добавл ют антибиотик (левомицетин, тетрациклин олететрин и т.д.) и сульфаниламидный препарат (например, этазол натри ) в соотношении 1:10 - 1:12.Mineral salts of hydroxyapatite Ca (PO) (OH) j or beta-tricalcium phosphate Cad (PO) Hj (OH) 60%, gelatin or collagen 30%, water 10% are taken. An antibiotic (chloramphenicol, tetracycline oletretrin, etc.) and a sulfanilamide preparation (for example, ethazole sodium) are added to the resulting mass in a ratio of 1:10 - 1:12.
Смесь тщательно перемешивают, помещают в формы нужной величины и после добавлени припо , например циакрина, воздействуют па нее ультра звуком с частотой колебаний 20 50 кГц в течение 1-3 мин (в зависимости от величины получаемого трансплантата ) .The mixture is thoroughly mixed, placed in the forms of the desired size and after adding solder, for example cyacrine, it is affected by ultra sound with an oscillation frequency of 20–50 kHz for 1–3 minutes (depending on the size of the graft obtained).
В результате образуетс искусственный костный трансплантат заданного размера и формы, обладающий длительно действующими противовоспалительными свойствами.As a result, an artificial bone graft of a given size and shape, with long-lasting anti-inflammatory properties, is formed.
Пример, Дл изготовлени диа физарного (цилиндрической формы) искусственного костного трансплантата размером 2,5x0,5 см, весом 1,5г берут смесь: минеральна соль гидроок- сиапатита Са , (РО) (ОН) 60% (90 мг), желатин 30% (45 мг), кетгут 4% (6 мг), остальное вода 6% (9 мг). К полученной смеси добавл ют антибиотик левомицетин и сульфаниламидный препарат - этазол натри в количестве 1,5 мг (т.е., 1:10 к общей массе). Полученную массу поРедактор Н.ТупицаExample: For the manufacture of a diaphonic (cylindrical) artificial bone graft 2.5x0.5 cm in size, weighing 1.5 g, take the mixture: hydroxiapatite Ca mineral salt, (PO) (OH) 60% (90 mg), gelatin 30 % (45 mg), catgut 4% (6 mg), the rest water 6% (9 mg). An antibiotic chloramphenicol and a sulfa drug — etazol sodium in an amount of 1.5 mg (i.e., 1:10 to the total mass) are added to the mixture. The resulting mass by Editor N. Tupitsa
Составитель Л.Морозова Техред М.ДидыкCompiled by L.Morozova Tehred M.Didyk
Заказ 3749/АOrder 3749 / A
Тираж 594ПодписноеCirculation 594 Subscription
ВПИИПИ Государственного комитета СССРVPIIPI USSR State Committee
по делам изобретений и открытий 113035, Мосгва, Ж-35, Раушска наб., д.4/5for inventions and discoveries 113035, Mosgva, Zh-35, Raushsk nab., d.4 / 5
Производственно-полиграфическое предпри тие, г.Ужгород, ул.Проектна , АProduction and printing company, Uzhgorod, Projecto st., A
5five
315012315012
мещают в цилиндрическую форму длиной 2,5, диаметром 0,5 см. Добавл ют 3 капли жидкого припо , например циакрина , после чего производ т ультразвуковое озвучивание волноводом с частЬтой колебаний 26 кГц в течение 30 с. В результате образуетс искусственна костна ткань в виде транс- Q плантата заданных размеров, обладающа противовоспалительными свойствами .placed in a cylindrical shape with a length of 2.5, with a diameter of 0.5 cm. Three drops of liquid solder, such as cyacrine, are added, after which an ultrasonic sounding of the waveguide with a partial oscillation of 26 kHz is performed for 30 s. As a result, artificial bone tissue is formed in the form of a trans-Q plantation of a given size, which has anti-inflammatory properties.
После заполнени дефекта в трубча- g той кости животного полученным трансплантатом постепенно произошло замещение искусственной кости вновь образованной костной тканью, что вл етс оптимальным результатом транс20After filling the defect in the tubular g of the animal bone with the graft, the artificial bone gradually replaced the newly formed bone tissue, which is the best result of the trans
плантации костной ткани. Как в ближайшие , так и в отдаленные сроки каких-либо воспалительных осложнений не наблюдалось.bone plantation. No inflammatory complications were observed either in the immediate or long-term periods.
Дополнительные лечебные препара- 5 ты в организм животного не вводились.Additional medicinal preparations — 5 were not administered to the animal.
Способ позвол ет предупредить возможные осложнени при операци х в травматологии, военно-полевой хирургии и ортопедии.The method makes it possible to prevent possible complications in operations in traumatology, military field surgery and orthopedics.
00
Claims (1)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SU833608246A SU1331501A1 (en) | 1983-06-22 | 1983-06-22 | Method of obtaining artificial osseous transplants |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SU833608246A SU1331501A1 (en) | 1983-06-22 | 1983-06-22 | Method of obtaining artificial osseous transplants |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SU1331501A1 true SU1331501A1 (en) | 1987-08-23 |
Family
ID=21069457
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SU833608246A SU1331501A1 (en) | 1983-06-22 | 1983-06-22 | Method of obtaining artificial osseous transplants |
Country Status (1)
| Country | Link |
|---|---|
| SU (1) | SU1331501A1 (en) |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4880610A (en) * | 1988-04-20 | 1989-11-14 | Norian Corporation | In situ calcium phosphate minerals--method and composition |
| US5047031A (en) * | 1988-04-20 | 1991-09-10 | Norian Corporation | In situ calcium phosphate minerals method |
| US5053212A (en) * | 1988-04-20 | 1991-10-01 | Norian Corporation | Intimate mixture of calcium and phosphate sources as precursor to hydroxyapatite |
| US5129905A (en) * | 1988-04-20 | 1992-07-14 | Norian Corporation | Methods for in situ prepared calcium phosphate minerals |
| US5178845A (en) * | 1988-04-20 | 1993-01-12 | Norian Corporation | Intimate mixture of calcium and phosphate sources as precursor to hydroxyapatite |
| US6005162A (en) * | 1988-04-20 | 1999-12-21 | Norian Corporation | Methods of repairing bone |
| RU2174848C1 (en) * | 2000-08-17 | 2001-10-20 | Литвинов Сергей Дмитриевич | Method for forming bone tissue on the calcium phosphate (hydroxyapatite) base |
| RU2205614C2 (en) * | 2001-03-19 | 2003-06-10 | Махсон Анатолий Нахимович | Method for manufacturing artificial rib |
-
1983
- 1983-06-22 SU SU833608246A patent/SU1331501A1/en active
Non-Patent Citations (1)
| Title |
|---|
| Авторское свидетельство СССР № 1005344, кл. А 61 К 33/06, 1981. * |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4880610A (en) * | 1988-04-20 | 1989-11-14 | Norian Corporation | In situ calcium phosphate minerals--method and composition |
| US5047031A (en) * | 1988-04-20 | 1991-09-10 | Norian Corporation | In situ calcium phosphate minerals method |
| US5053212A (en) * | 1988-04-20 | 1991-10-01 | Norian Corporation | Intimate mixture of calcium and phosphate sources as precursor to hydroxyapatite |
| US5129905A (en) * | 1988-04-20 | 1992-07-14 | Norian Corporation | Methods for in situ prepared calcium phosphate minerals |
| US5178845A (en) * | 1988-04-20 | 1993-01-12 | Norian Corporation | Intimate mixture of calcium and phosphate sources as precursor to hydroxyapatite |
| US6005162A (en) * | 1988-04-20 | 1999-12-21 | Norian Corporation | Methods of repairing bone |
| RU2174848C1 (en) * | 2000-08-17 | 2001-10-20 | Литвинов Сергей Дмитриевич | Method for forming bone tissue on the calcium phosphate (hydroxyapatite) base |
| RU2205614C2 (en) * | 2001-03-19 | 2003-06-10 | Махсон Анатолий Нахимович | Method for manufacturing artificial rib |
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