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SU1282510A1 - Substituted 1,2-dihydro-5-morpholino-4h-pyrano-[4′,3′:4,5]-pyrido-[2,3-b]-thieno-[3,2-d]-pyrimidine-8(9h)-one or -[9,11]-oxazine-8-one showing antibacterial effect - Google Patents

Substituted 1,2-dihydro-5-morpholino-4h-pyrano-[4′,3′:4,5]-pyrido-[2,3-b]-thieno-[3,2-d]-pyrimidine-8(9h)-one or -[9,11]-oxazine-8-one showing antibacterial effect

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Publication number
SU1282510A1
SU1282510A1 SU3914497/04;3922443/04A SU3914497A SU1282510A1 SU 1282510 A1 SU1282510 A1 SU 1282510A1 SU 3914497 A SU3914497 A SU 3914497A SU 1282510 A1 SU1282510 A1 SU 1282510A1
Authority
SU
USSR - Soviet Union
Prior art keywords
pyrano
thieno
morpholino
dihydro
pyrido
Prior art date
Application number
SU3914497/04;3922443/04A
Other languages
Russian (ru)
Inventor
Е.Г. Пароникян
А.С. Норавян
Г.В. Мирзоян
С.А. Вартанян
Ю.З. Тер-Захарян
Ш.Г. Оганян
Original Assignee
Институт Тонкой Органической Химии Им.А.Л.Мнджояна
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Институт Тонкой Органической Химии Им.А.Л.Мнджояна filed Critical Институт Тонкой Органической Химии Им.А.Л.Мнджояна
Priority to SU3914497/04;3922443/04A priority Critical patent/SU1282510A1/en
Application granted granted Critical
Publication of SU1282510A1 publication Critical patent/SU1282510A1/en

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    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

FIELD: fused heterocyclic compounds. SUBSTANCE: product: 1,2-dihydro-2,2-dimethyl-5-morpholino-4H-pyrano-[4′,3:4,5: 4,5] -pyrido-[2,3-b]-thieno-[3,2-d] -pyrimidine-8(9H)-one (I) or 1,2-dihydro-5-morpholino-8-oxo-2,2,10-trimethyl-4H-pyrano-[$$-$: 4,5]-pyrido-[2,3-b]-thieno-[3,2-d]-[9,11]-oxazine (II). Synthesis of (I) is carried out by boiling 3-amino-2-carbethoxy-5,5-dimethyl-8-(N-morpholino)-4,5-dihydro-7H-pyrano-[4,3-d]-thieno-[2,3-b]-pyridine and formamide for 2 h and precipitate is separated. The yield is 85.5% m. p. is 371-372 C, R0.68 (in dimethylformamide-ether, 2:5). Synthesis of (II) is carried out by boiling 3-amino-5,5-dimethyl-8-morpholino-2-carbethoxy-4,5-dihydro-7H- -pyrano-[4,3-d] -thieno-[2,3-b]-pyridine in the medium of (CHCO)O for 1 h. Precipitate is separated after cooling. The yield of (II) is 68.4% m. p. is 301-302 C. Effectiveness of (I) and (II) against staphylococcus and dysentery bacillus is at the level that of norsulfazole but at dysentery septicemia their effect is lower. EFFECT: improved method of synthesis. 1 tbl
SU3914497/04;3922443/04A 1985-06-18 1985-06-18 Substituted 1,2-dihydro-5-morpholino-4h-pyrano-[4′,3′:4,5]-pyrido-[2,3-b]-thieno-[3,2-d]-pyrimidine-8(9h)-one or -[9,11]-oxazine-8-one showing antibacterial effect SU1282510A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
SU3914497/04;3922443/04A SU1282510A1 (en) 1985-06-18 1985-06-18 Substituted 1,2-dihydro-5-morpholino-4h-pyrano-[4′,3′:4,5]-pyrido-[2,3-b]-thieno-[3,2-d]-pyrimidine-8(9h)-one or -[9,11]-oxazine-8-one showing antibacterial effect

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SU3914497/04;3922443/04A SU1282510A1 (en) 1985-06-18 1985-06-18 Substituted 1,2-dihydro-5-morpholino-4h-pyrano-[4′,3′:4,5]-pyrido-[2,3-b]-thieno-[3,2-d]-pyrimidine-8(9h)-one or -[9,11]-oxazine-8-one showing antibacterial effect

Publications (1)

Publication Number Publication Date
SU1282510A1 true SU1282510A1 (en) 1995-09-20

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Family Applications (1)

Application Number Title Priority Date Filing Date
SU3914497/04;3922443/04A SU1282510A1 (en) 1985-06-18 1985-06-18 Substituted 1,2-dihydro-5-morpholino-4h-pyrano-[4′,3′:4,5]-pyrido-[2,3-b]-thieno-[3,2-d]-pyrimidine-8(9h)-one or -[9,11]-oxazine-8-one showing antibacterial effect

Country Status (1)

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SU (1) SU1282510A1 (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2198888C2 (en) * 1996-09-10 2003-02-20 Басф Акциенгезелльшафт 3-substituted derivatives of 3,4,5,6,7,8-hexahydro-pyrido-[4',3':4,5]-thieno[2,3- d]-pyrimidine
RU2261251C2 (en) * 2003-08-20 2005-09-27 ООО "Исследовательский институт химического разнообразия" Substituted 2h-pyrano[2,3-c]pyridines, combinatory and focused libraries
EP1623987A1 (en) * 2004-08-02 2006-02-08 Curacyte Discovery GmbH Fused pyrido[3',2':4,5]thieno[3,2-d]pyrimidines and pyrido[3',2':4,5]furo[3,2-d]pyrimidines

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2198888C2 (en) * 1996-09-10 2003-02-20 Басф Акциенгезелльшафт 3-substituted derivatives of 3,4,5,6,7,8-hexahydro-pyrido-[4',3':4,5]-thieno[2,3- d]-pyrimidine
RU2261251C2 (en) * 2003-08-20 2005-09-27 ООО "Исследовательский институт химического разнообразия" Substituted 2h-pyrano[2,3-c]pyridines, combinatory and focused libraries
EP1623987A1 (en) * 2004-08-02 2006-02-08 Curacyte Discovery GmbH Fused pyrido[3',2':4,5]thieno[3,2-d]pyrimidines and pyrido[3',2':4,5]furo[3,2-d]pyrimidines

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