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SU117044A1 - Method for preparing 1-phenyl-2, 3 dimethyl-4-dimethylaminopyrazolone-5 (pyramidone) - Google Patents

Method for preparing 1-phenyl-2, 3 dimethyl-4-dimethylaminopyrazolone-5 (pyramidone)

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Publication number
SU117044A1
SU117044A1 SU592449A SU592449A SU117044A1 SU 117044 A1 SU117044 A1 SU 117044A1 SU 592449 A SU592449 A SU 592449A SU 592449 A SU592449 A SU 592449A SU 117044 A1 SU117044 A1 SU 117044A1
Authority
SU
USSR - Soviet Union
Prior art keywords
pyramidone
dimethylaminopyrazolone
dimethyl
phenyl
preparing
Prior art date
Application number
SU592449A
Other languages
Russian (ru)
Inventor
Н.М. Колгина
А.А. Никифоров
В.С. Федоров
Original Assignee
Н.М. Колгина
А.А. Никифоров
В.С. Федоров
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Н.М. Колгина, А.А. Никифоров, В.С. Федоров filed Critical Н.М. Колгина
Priority to SU592449A priority Critical patent/SU117044A1/en
Application granted granted Critical
Publication of SU117044A1 publication Critical patent/SU117044A1/en

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Description

Изобретением  вл етс  способ получени  пирамидона, заключающийс  в том, что аминоантипирин формилирзют муравьиной кислотой, а полученный формиламиноантипирин обрабатывают метилирующей смесью, состо щей из 2,5 молей формалина и 3-4 молей муравьиной кислоты.The invention is a method for producing pyramidone, in that aminoantipyrine is formulated with formic acid, and the formylaminoantipyrine obtained is treated with a methylating mixture consisting of 2.5 moles of formalin and 3-4 moles of formic acid.

Способ осуществл етс - следующим образом.The method is carried out as follows.

В 700 мл воды загружают при размешивании 98,7 г 100%-ного 4-формиламиноантипирина и 92,4 г 85%-ной муравьиной кислоты. Раствор нагревают до 100° и выдерживают при этой температуре в течение 2-х час. Затем медленно при перемешивании в течение /-1 ч. 15 мин. приливают 88,4 г 36%-ного раствора формальдегида и при 100-102° выдерживают 7 час. К копцу метилировани  прибавл ют 0,2 % активированного угл , раствор нейтрализуют кальцинированной солой до рН 3,5-3,8 и фильтруют. К профильтрованному раствору при 70-80° прибавл ют кальпинированную соду до рН 6,5-6,7. Затем реакционную смесь охлаждают до 20-30°; выпавшие кристаллы пирамидона отЛипьтровывают и перекристаллизовывают обычным способом. В результате получают 98%-ный пирамидон в количестве 96,2 г, что составл ет 96,6% теоретического на формиламиноантипирин.In 700 ml of water, 98.7 g of 100% 4-formylaminoantipyrine and 92.4 g of 85% formic acid are loaded with stirring. The solution is heated to 100 ° and maintained at this temperature for 2 hours. Then slowly with stirring for / -1 h. 15 min. 88.4 g of a 36% formaldehyde solution are poured in and kept at 100-102 ° for 7 hours. 0.2% activated carbon was added to methylation grab, the solution was neutralized with calcined salt to pH 3.5-3.8 and filtered. To the filtered solution at 70-80 °, calcinated soda is added to a pH of 6.5-6.7. Then the reaction mixture is cooled to 20-30 °; the precipitated pyramidone crystals from the liquid are recrystallized and recrystallized in the usual way. The result is 98% pyramidone in the amount of 96.2 g, which is 96.6% of the theoretical for formylaminoantipyrin.

Предмет изобретени Subject invention

Способ получени  1-фенил-2,3-диметил-4-диметиламинопиразолона-5 (пирамидона) метилированием аминоантипирина смесью формалина и муравьиной кислоты, отличающийс  тем, что, с целью освобождени  от смолистых и побочных продуктов, изолированный продукт 4-формиламиноантипирин получают путем формилировани  аминоантиЛо 117044The method of obtaining 1-phenyl-2,3-dimethyl-4-dimethylaminopyrazolone-5 (pyramidone) by methylation of aminoantipyrine with a mixture of formalin and formic acid, characterized in that, in order to release resinous and by-products, the isolated product 4-formylaminoantipyrine is obtained by formylation AminoantiLo 117044

пирина муравьиной кислотой, метилируют смесью, формалина и муравьиной кислоты, после чего полученный пирамидон выдел ют щелочами и перекристаллизовывают из изопропилового или этилового спирта известными приемами.pyrine is formic acid, methylated with a mixture of formalin and formic acid, after which the resulting pyramidone is isolated with alkalis and recrystallized from isopropyl or ethyl alcohol by known methods.

SU592449A 1958-02-17 1958-02-17 Method for preparing 1-phenyl-2, 3 dimethyl-4-dimethylaminopyrazolone-5 (pyramidone) SU117044A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
SU592449A SU117044A1 (en) 1958-02-17 1958-02-17 Method for preparing 1-phenyl-2, 3 dimethyl-4-dimethylaminopyrazolone-5 (pyramidone)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SU592449A SU117044A1 (en) 1958-02-17 1958-02-17 Method for preparing 1-phenyl-2, 3 dimethyl-4-dimethylaminopyrazolone-5 (pyramidone)

Publications (1)

Publication Number Publication Date
SU117044A1 true SU117044A1 (en) 1958-11-30

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Family Applications (1)

Application Number Title Priority Date Filing Date
SU592449A SU117044A1 (en) 1958-02-17 1958-02-17 Method for preparing 1-phenyl-2, 3 dimethyl-4-dimethylaminopyrazolone-5 (pyramidone)

Country Status (1)

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SU (1) SU117044A1 (en)

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