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SMT202300001T1 - Metodi di preparazione di derivati citotossici di benzodiazepina - Google Patents

Metodi di preparazione di derivati citotossici di benzodiazepina

Info

Publication number
SMT202300001T1
SMT202300001T1 SM20230001T SMT202300001T SMT202300001T1 SM T202300001 T1 SMT202300001 T1 SM T202300001T1 SM 20230001 T SM20230001 T SM 20230001T SM T202300001 T SMT202300001 T SM T202300001T SM T202300001 T1 SMT202300001 T1 SM T202300001T1
Authority
SM
San Marino
Prior art keywords
methods
benzodiazepine derivatives
cytotoxic benzodiazepine
preparing cytotoxic
preparing
Prior art date
Application number
SM20230001T
Other languages
English (en)
Inventor
Baudouin Gérard
Manami Shizuka
Michael Louis Miller
Richard A Silva
Original Assignee
Immunogen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Immunogen Inc filed Critical Immunogen Inc
Publication of SMT202300001T1 publication Critical patent/SMT202300001T1/it

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06Dipeptides
    • C07K5/06008Dipeptides with the first amino acid being neutral
    • C07K5/06017Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C201/00Preparation of esters of nitric or nitrous acid or of compounds containing nitro or nitroso groups bound to a carbon skeleton
    • C07C201/06Preparation of nitro compounds
    • C07C201/16Separation; Purification; Stabilisation; Use of additives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C201/00Preparation of esters of nitric or nitrous acid or of compounds containing nitro or nitroso groups bound to a carbon skeleton
    • C07C201/06Preparation of nitro compounds
    • C07C201/12Preparation of nitro compounds by reactions not involving the formation of nitro groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/13Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by hydroxy groups
    • C07C205/19Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by hydroxy groups having nitro groups bound to carbon atoms of six-membered aromatic rings and hydroxy groups bound to acyclic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D207/00Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/44Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members
    • C07D207/444Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members having two doubly-bound oxygen atoms directly attached in positions 2 and 5
    • C07D207/448Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members having two doubly-bound oxygen atoms directly attached in positions 2 and 5 with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms, e.g. maleimide
    • C07D207/452Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members having two doubly-bound oxygen atoms directly attached in positions 2 and 5 with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms, e.g. maleimide with hydrocarbon radicals, substituted by hetero atoms, directly attached to the ring nitrogen atom
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D519/00Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D519/00Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C07D519/04Dimeric indole alkaloids, e.g. vincaleucoblastine
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07Optical isomers
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicinal Preparation (AREA)
SM20230001T 2017-01-25 2018-01-24 Metodi di preparazione di derivati citotossici di benzodiazepina SMT202300001T1 (it)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762450270P 2017-01-25 2017-01-25
PCT/US2018/014956 WO2018140435A1 (en) 2017-01-25 2018-01-24 Methods of preparing cytotoxic benzodiazepine derivatives
EP18704352.6A EP3573948B1 (en) 2017-01-25 2018-01-24 Methods of preparing cytotoxic benzodiazepine derivatives

Publications (1)

Publication Number Publication Date
SMT202300001T1 true SMT202300001T1 (it) 2023-03-17

Family

ID=61189535

Family Applications (1)

Application Number Title Priority Date Filing Date
SM20230001T SMT202300001T1 (it) 2017-01-25 2018-01-24 Metodi di preparazione di derivati citotossici di benzodiazepina

Country Status (23)

Country Link
US (4) US10385071B2 (it)
EP (2) EP4148044A1 (it)
JP (3) JP7066725B2 (it)
KR (2) KR20230005410A (it)
CN (3) CN116554262A (it)
AU (3) AU2018213202B2 (it)
CA (1) CA3050262A1 (it)
DK (1) DK3573948T3 (it)
ES (1) ES2935346T3 (it)
FI (1) FI3573948T3 (it)
HR (1) HRP20230002T1 (it)
HU (1) HUE060746T2 (it)
IL (3) IL287405B (it)
LT (1) LT3573948T (it)
PL (1) PL3573948T3 (it)
PT (1) PT3573948T (it)
RS (1) RS63871B1 (it)
RU (2) RU2762891C2 (it)
SG (1) SG11201906666QA (it)
SI (1) SI3573948T1 (it)
SM (1) SMT202300001T1 (it)
TW (3) TWI805325B (it)
WO (1) WO2018140435A1 (it)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116554262A (zh) 2017-01-25 2023-08-08 伊缪诺金公司 制备细胞毒性苯二氮䓬衍生物的方法
SG11202104360YA (en) 2018-11-12 2021-05-28 Immunogen Inc Methods of preparing cytotoxic benzodiazepine derivatives
IL308670A (en) * 2018-11-12 2024-01-01 Immunogen Inc Methods of preparing cytotoxic benzodiazepine derivatives
KR20220010481A (ko) * 2019-03-29 2022-01-25 이뮤노젠 아이엔씨 비정상 세포 성장의 억제 또는 증식성 질환의 치료를 위한 세포독성 비스-벤조디아제핀 유도체 및 세포결합제와 이의 접합체
KR20250031149A (ko) 2022-06-30 2025-03-06 도레이 카부시키가이샤 암의 치료 및/또는 예방용 의약 조성물

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9018601D0 (en) 1990-08-24 1990-10-10 Fujisawa Pharmaceutical Co Tricyclic compounds
EP2668187B1 (en) 2010-12-21 2014-10-15 Janssen Pharmaceutica, N.V. NOVEL ANTIFUNGAL 5,6-DIHYDRO-4H-PYRROLO[1,2-a][1,4]- BENZODIAZEPINES AND 6H-PYRROLO[1,2-a][1,4]BENZODIAZEPINES SUBSTITUTED WITH BICYCLIC BENZENE DERIVATIVES
EP3666289A1 (en) * 2011-02-15 2020-06-17 ImmunoGen, Inc. Cytotoxic benzodiazepine derivatives
BR112017014599A2 (pt) * 2015-01-14 2018-01-16 Bristol-Myers Squibb Company dímeros de benzodiazepina, conjugados dos mesmos, e métodos de preparação e uso
JP7203497B2 (ja) * 2015-06-29 2023-01-13 イミュノジェン・インコーポレーテッド 抗cd123抗体、ならびにその複合体及び誘導体
CN113004288A (zh) * 2015-07-21 2021-06-22 伊缪诺金公司 制备细胞毒性苯并二氮杂䓬衍生物的方法
CN116554262A (zh) 2017-01-25 2023-08-08 伊缪诺金公司 制备细胞毒性苯二氮䓬衍生物的方法

Also Published As

Publication number Publication date
SG11201906666QA (en) 2019-08-27
CN116554262A (zh) 2023-08-08
HUE060746T2 (hu) 2023-04-28
AU2018213202B2 (en) 2022-03-24
AU2022201572A1 (en) 2022-03-31
FI3573948T3 (fi) 2023-01-13
JP7066725B2 (ja) 2022-05-13
RU2019125133A3 (it) 2021-05-27
US20210139510A1 (en) 2021-05-13
US10385071B2 (en) 2019-08-20
TWI763771B (zh) 2022-05-11
US20230039161A1 (en) 2023-02-09
IL287405B (en) 2022-07-01
CN110225904B (zh) 2023-10-27
WO2018140435A9 (en) 2018-12-27
PL3573948T3 (pl) 2023-01-30
RS63871B1 (sr) 2023-02-28
KR102480594B1 (ko) 2022-12-26
US11390633B2 (en) 2022-07-19
LT3573948T (lt) 2023-02-10
IL268213B (en) 2021-12-01
PT3573948T (pt) 2023-01-11
EP3573948A1 (en) 2019-12-04
JP2024028860A (ja) 2024-03-05
RU2021138005A (ru) 2022-01-18
EP3573948B1 (en) 2022-10-05
KR20230005410A (ko) 2023-01-09
JP2020505404A (ja) 2020-02-20
TWI805325B (zh) 2023-06-11
TW201831495A (zh) 2018-09-01
IL293645A (en) 2022-08-01
WO2018140435A1 (en) 2018-08-02
KR20190116331A (ko) 2019-10-14
AU2022201572B2 (en) 2024-03-14
IL268213A (en) 2019-09-26
DK3573948T3 (da) 2023-01-09
AU2018213202A1 (en) 2019-08-22
SI3573948T1 (sl) 2023-03-31
EP4148044A1 (en) 2023-03-15
CN116102615A (zh) 2023-05-12
CA3050262A1 (en) 2018-08-02
RU2762891C2 (ru) 2021-12-23
TW202400551A (zh) 2024-01-01
IL287405A (en) 2021-12-01
TW202229226A (zh) 2022-08-01
ES2935346T3 (es) 2023-03-06
US10844078B2 (en) 2020-11-24
HRP20230002T1 (hr) 2023-02-17
US20180251474A1 (en) 2018-09-06
US20200002360A1 (en) 2020-01-02
JP7400005B2 (ja) 2023-12-18
RU2019125133A (ru) 2021-02-26
AU2024201119A1 (en) 2024-03-14
CN110225904A (zh) 2019-09-10
JP2022105096A (ja) 2022-07-12
US11981687B2 (en) 2024-05-14

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