SMT202300001T1 - Metodi di preparazione di derivati citotossici di benzodiazepina - Google Patents
Metodi di preparazione di derivati citotossici di benzodiazepinaInfo
- Publication number
- SMT202300001T1 SMT202300001T1 SM20230001T SMT202300001T SMT202300001T1 SM T202300001 T1 SMT202300001 T1 SM T202300001T1 SM 20230001 T SM20230001 T SM 20230001T SM T202300001 T SMT202300001 T SM T202300001T SM T202300001 T1 SMT202300001 T1 SM T202300001T1
- Authority
- SM
- San Marino
- Prior art keywords
- methods
- benzodiazepine derivatives
- cytotoxic benzodiazepine
- preparing cytotoxic
- preparing
- Prior art date
Links
- 229940053197 benzodiazepine derivative antiepileptics Drugs 0.000 title 1
- 125000003310 benzodiazepinyl group Chemical class N1N=C(C=CC2=C1C=CC=C2)* 0.000 title 1
- 231100000433 cytotoxic Toxicity 0.000 title 1
- 230000001472 cytotoxic effect Effects 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C201/00—Preparation of esters of nitric or nitrous acid or of compounds containing nitro or nitroso groups bound to a carbon skeleton
- C07C201/06—Preparation of nitro compounds
- C07C201/16—Separation; Purification; Stabilisation; Use of additives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C201/00—Preparation of esters of nitric or nitrous acid or of compounds containing nitro or nitroso groups bound to a carbon skeleton
- C07C201/06—Preparation of nitro compounds
- C07C201/12—Preparation of nitro compounds by reactions not involving the formation of nitro groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
- C07C205/13—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by hydroxy groups
- C07C205/19—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by hydroxy groups having nitro groups bound to carbon atoms of six-membered aromatic rings and hydroxy groups bound to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/44—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members
- C07D207/444—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members having two doubly-bound oxygen atoms directly attached in positions 2 and 5
- C07D207/448—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members having two doubly-bound oxygen atoms directly attached in positions 2 and 5 with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms, e.g. maleimide
- C07D207/452—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members having two doubly-bound oxygen atoms directly attached in positions 2 and 5 with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms, e.g. maleimide with hydrocarbon radicals, substituted by hetero atoms, directly attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
- C07D519/04—Dimeric indole alkaloids, e.g. vincaleucoblastine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Peptides Or Proteins (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201762450270P | 2017-01-25 | 2017-01-25 | |
PCT/US2018/014956 WO2018140435A1 (en) | 2017-01-25 | 2018-01-24 | Methods of preparing cytotoxic benzodiazepine derivatives |
EP18704352.6A EP3573948B1 (en) | 2017-01-25 | 2018-01-24 | Methods of preparing cytotoxic benzodiazepine derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
SMT202300001T1 true SMT202300001T1 (it) | 2023-03-17 |
Family
ID=61189535
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SM20230001T SMT202300001T1 (it) | 2017-01-25 | 2018-01-24 | Metodi di preparazione di derivati citotossici di benzodiazepina |
Country Status (23)
Country | Link |
---|---|
US (4) | US10385071B2 (it) |
EP (2) | EP4148044A1 (it) |
JP (3) | JP7066725B2 (it) |
KR (2) | KR20230005410A (it) |
CN (3) | CN116554262A (it) |
AU (3) | AU2018213202B2 (it) |
CA (1) | CA3050262A1 (it) |
DK (1) | DK3573948T3 (it) |
ES (1) | ES2935346T3 (it) |
FI (1) | FI3573948T3 (it) |
HR (1) | HRP20230002T1 (it) |
HU (1) | HUE060746T2 (it) |
IL (3) | IL287405B (it) |
LT (1) | LT3573948T (it) |
PL (1) | PL3573948T3 (it) |
PT (1) | PT3573948T (it) |
RS (1) | RS63871B1 (it) |
RU (2) | RU2762891C2 (it) |
SG (1) | SG11201906666QA (it) |
SI (1) | SI3573948T1 (it) |
SM (1) | SMT202300001T1 (it) |
TW (3) | TWI805325B (it) |
WO (1) | WO2018140435A1 (it) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN116554262A (zh) | 2017-01-25 | 2023-08-08 | 伊缪诺金公司 | 制备细胞毒性苯二氮䓬衍生物的方法 |
SG11202104360YA (en) | 2018-11-12 | 2021-05-28 | Immunogen Inc | Methods of preparing cytotoxic benzodiazepine derivatives |
IL308670A (en) * | 2018-11-12 | 2024-01-01 | Immunogen Inc | Methods of preparing cytotoxic benzodiazepine derivatives |
KR20220010481A (ko) * | 2019-03-29 | 2022-01-25 | 이뮤노젠 아이엔씨 | 비정상 세포 성장의 억제 또는 증식성 질환의 치료를 위한 세포독성 비스-벤조디아제핀 유도체 및 세포결합제와 이의 접합체 |
KR20250031149A (ko) | 2022-06-30 | 2025-03-06 | 도레이 카부시키가이샤 | 암의 치료 및/또는 예방용 의약 조성물 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9018601D0 (en) | 1990-08-24 | 1990-10-10 | Fujisawa Pharmaceutical Co | Tricyclic compounds |
EP2668187B1 (en) | 2010-12-21 | 2014-10-15 | Janssen Pharmaceutica, N.V. | NOVEL ANTIFUNGAL 5,6-DIHYDRO-4H-PYRROLO[1,2-a][1,4]- BENZODIAZEPINES AND 6H-PYRROLO[1,2-a][1,4]BENZODIAZEPINES SUBSTITUTED WITH BICYCLIC BENZENE DERIVATIVES |
EP3666289A1 (en) * | 2011-02-15 | 2020-06-17 | ImmunoGen, Inc. | Cytotoxic benzodiazepine derivatives |
BR112017014599A2 (pt) * | 2015-01-14 | 2018-01-16 | Bristol-Myers Squibb Company | dímeros de benzodiazepina, conjugados dos mesmos, e métodos de preparação e uso |
JP7203497B2 (ja) * | 2015-06-29 | 2023-01-13 | イミュノジェン・インコーポレーテッド | 抗cd123抗体、ならびにその複合体及び誘導体 |
CN113004288A (zh) * | 2015-07-21 | 2021-06-22 | 伊缪诺金公司 | 制备细胞毒性苯并二氮杂䓬衍生物的方法 |
CN116554262A (zh) | 2017-01-25 | 2023-08-08 | 伊缪诺金公司 | 制备细胞毒性苯二氮䓬衍生物的方法 |
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2018
- 2018-01-24 CN CN202310124650.6A patent/CN116554262A/zh active Pending
- 2018-01-24 TW TW111114178A patent/TWI805325B/zh active
- 2018-01-24 LT LTEPPCT/US2018/014956T patent/LT3573948T/lt unknown
- 2018-01-24 SI SI201830832T patent/SI3573948T1/sl unknown
- 2018-01-24 US US15/878,991 patent/US10385071B2/en active Active
- 2018-01-24 EP EP22199432.0A patent/EP4148044A1/en not_active Withdrawn
- 2018-01-24 IL IL287405A patent/IL287405B/en unknown
- 2018-01-24 PL PL18704352.6T patent/PL3573948T3/pl unknown
- 2018-01-24 DK DK18704352.6T patent/DK3573948T3/da active
- 2018-01-24 EP EP18704352.6A patent/EP3573948B1/en active Active
- 2018-01-24 JP JP2019540404A patent/JP7066725B2/ja active Active
- 2018-01-24 RS RS20221193A patent/RS63871B1/sr unknown
- 2018-01-24 CN CN202310124604.6A patent/CN116102615A/zh active Pending
- 2018-01-24 RU RU2019125133A patent/RU2762891C2/ru active
- 2018-01-24 HR HRP20230002TT patent/HRP20230002T1/hr unknown
- 2018-01-24 IL IL293645A patent/IL293645A/en unknown
- 2018-01-24 WO PCT/US2018/014956 patent/WO2018140435A1/en unknown
- 2018-01-24 KR KR1020227044421A patent/KR20230005410A/ko active Pending
- 2018-01-24 CN CN201880008141.4A patent/CN110225904B/zh active Active
- 2018-01-24 SM SM20230001T patent/SMT202300001T1/it unknown
- 2018-01-24 ES ES18704352T patent/ES2935346T3/es active Active
- 2018-01-24 TW TW112117953A patent/TW202400551A/zh unknown
- 2018-01-24 CA CA3050262A patent/CA3050262A1/en active Pending
- 2018-01-24 PT PT187043526T patent/PT3573948T/pt unknown
- 2018-01-24 TW TW107102506A patent/TWI763771B/zh active
- 2018-01-24 HU HUE18704352A patent/HUE060746T2/hu unknown
- 2018-01-24 KR KR1020197024738A patent/KR102480594B1/ko active Active
- 2018-01-24 FI FIEP18704352.6T patent/FI3573948T3/fi active
- 2018-01-24 RU RU2021138005A patent/RU2021138005A/ru unknown
- 2018-01-24 AU AU2018213202A patent/AU2018213202B2/en active Active
- 2018-01-24 SG SG11201906666QA patent/SG11201906666QA/en unknown
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2019
- 2019-06-17 US US16/442,718 patent/US10844078B2/en active Active
- 2019-07-22 IL IL268213A patent/IL268213B/en unknown
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2020
- 2020-10-22 US US17/077,688 patent/US11390633B2/en active Active
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2022
- 2022-03-07 AU AU2022201572A patent/AU2022201572B2/en active Active
- 2022-04-27 JP JP2022072946A patent/JP7400005B2/ja active Active
- 2022-06-15 US US17/841,026 patent/US11981687B2/en active Active
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2023
- 2023-12-06 JP JP2023205788A patent/JP2024028860A/ja not_active Withdrawn
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2024
- 2024-02-21 AU AU2024201119A patent/AU2024201119A1/en active Pending
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