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SMT201900622T1 - Derivati di 7-(morfolinil)-2-(n-piperazinil) metil tieno [2, 3-c]piridina come farmaci anticancro - Google Patents

Derivati di 7-(morfolinil)-2-(n-piperazinil) metil tieno [2, 3-c]piridina come farmaci anticancro

Info

Publication number
SMT201900622T1
SMT201900622T1 SM20190622T SMT201900622T SMT201900622T1 SM T201900622 T1 SMT201900622 T1 SM T201900622T1 SM 20190622 T SM20190622 T SM 20190622T SM T201900622 T SMT201900622 T SM T201900622T SM T201900622 T1 SMT201900622 T1 SM T201900622T1
Authority
SM
San Marino
Prior art keywords
piperazinyl
morpholinyl
anticancer drugs
pyridine derivatives
methyl thieno
Prior art date
Application number
SM20190622T
Other languages
English (en)
Inventor
Kali Satya Bhujanga Rao Adibhatla
Venkaiah Chowdary Nannapaneni
Durga Prasad Konakanchi
Subba Rao Pula
Rama Krishna Pilli
Lakshmana Viswa Venkata Pavan Kumar Maddula
Srinivasa Krishna Murthy Konduri
Janaki Rama Rao Ravi
Naga Vasanta Srinivasu Vuppalapati
Sandeep Kumar Thoota
Pulla Reddy Muddasani
Original Assignee
Natco Pharma Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Natco Pharma Ltd filed Critical Natco Pharma Ltd
Publication of SMT201900622T1 publication Critical patent/SMT201900622T1/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system having sulfur as a ring hetero atom, e.g. ticlopidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
SM20190622T 2014-12-11 2014-12-11 Derivati di 7-(morfolinil)-2-(n-piperazinil) metil tieno [2, 3-c]piridina come farmaci anticancro SMT201900622T1 (it)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/IN2014/000770 WO2016092556A1 (en) 2014-12-11 2014-12-11 7-(morpholinyl)-2-(n-piperazinyl) methyl thieno [2, 3-c] pyridine derivatives as anticancer drugs
EP14841337.0A EP3230289B1 (en) 2014-12-11 2014-12-11 7-(morpholinyl)-2-(n-piperazinyl) methyl thieno [2, 3-c]pyridine derivatives as anticancer drugs

Publications (1)

Publication Number Publication Date
SMT201900622T1 true SMT201900622T1 (it) 2020-01-14

Family

ID=52595387

Family Applications (1)

Application Number Title Priority Date Filing Date
SM20190622T SMT201900622T1 (it) 2014-12-11 2014-12-11 Derivati di 7-(morfolinil)-2-(n-piperazinil) metil tieno [2, 3-c]piridina come farmaci anticancro

Country Status (32)

Country Link
US (1) US10106554B2 (it)
EP (1) EP3230289B1 (it)
JP (1) JP6454419B2 (it)
KR (1) KR102328921B1 (it)
CN (1) CN107074873B (it)
AP (1) AP2017009749A0 (it)
AU (1) AU2014413483B2 (it)
BR (1) BR112017005518B1 (it)
CA (1) CA2959980C (it)
CO (1) CO2017002266A2 (it)
CY (1) CY1122080T1 (it)
DK (1) DK3230289T3 (it)
EA (1) EA036819B1 (it)
ES (1) ES2750268T3 (it)
HR (1) HRP20192041T1 (it)
HU (1) HUE047144T2 (it)
IL (1) IL252254B (it)
LT (1) LT3230289T (it)
MA (1) MA40110B2 (it)
MX (1) MX2017004782A (it)
MY (1) MY188946A (it)
NZ (1) NZ729078A (it)
PH (1) PH12017500342B1 (it)
PL (1) PL3230289T3 (it)
PT (1) PT3230289T (it)
RS (1) RS59409B1 (it)
SG (1) SG11201702162PA (it)
SI (1) SI3230289T1 (it)
SM (1) SMT201900622T1 (it)
UA (1) UA117318C2 (it)
WO (1) WO2016092556A1 (it)
ZA (1) ZA201701036B (it)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021072232A1 (en) * 2019-10-11 2021-04-15 Incyte Corporation Bicyclic amines as cdk2 inhibitors
US20230046892A1 (en) 2019-12-20 2023-02-16 Bayer Aktiengesellschaft Substituted thiophene carboxamides, thiophene carboxylic acids and derivatives thereof
JP2024517127A (ja) * 2021-04-21 2024-04-19 ナトコ ファーマ リミテッド ７－（モルホリニル）－２－（Ｎ－ピペラジニル）メチルチエノ［２，３－ｃ］ピリジン誘導体の調製のための改良プロセス
US11981671B2 (en) 2021-06-21 2024-05-14 Incyte Corporation Bicyclic pyrazolyl amines as CDK2 inhibitors
US11976073B2 (en) 2021-12-10 2024-05-07 Incyte Corporation Bicyclic amines as CDK2 inhibitors

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3579526A (en) 1968-11-13 1971-05-18 Research Corp Preparation of thienopyridines
FR2411838A1 (fr) 1977-12-19 1979-07-13 Parcor Nouveaux derives des thieno (2-3-c) et (3,2-c) pyridines, leurs procede de preparation et leur application therapeutique
US4839365A (en) 1987-05-19 1989-06-13 Shinogi & Co., Ltd. Thienopyridine derivatives useful in treating gastric ulcers
US6232320B1 (en) 1998-06-04 2001-05-15 Abbott Laboratories Cell adhesion-inhibiting antiinflammatory compounds
WO2000075145A1 (en) 1999-06-03 2000-12-14 Abbott Laboratories Cell adhesion-inhibiting antiinflammatory compounds
EP1753428A4 (en) * 2004-05-14 2010-09-15 Abbott Lab INHIBITORS OF KINASES AS THERAPEUTIC AGENTS
US8252792B2 (en) * 2006-04-26 2012-08-28 F. Hoffman-La Roche Ag Pyrimidine derivatives as PI3K inhibitors
GB0608264D0 (en) * 2006-04-26 2006-06-07 Piramed Ltd Pharmaceutical compounds
ES2537352T3 (es) * 2007-09-12 2015-06-05 Genentech, Inc. Combinaciones de compuestos inhibidores de fosfoinositida 3-cinasa y agentes quimioterapéuticos, y metodos para su uso
GB0723748D0 (en) 2007-12-04 2008-01-16 Ucb Pharma Sa Therapeutic agents
ES2480994T3 (es) 2008-03-31 2014-07-29 Genentech, Inc. Compuestos de tipo benzopirano y benzoxepina inhibidores de PI3K y métodos de uso
EA024252B1 (ru) * 2009-01-08 2016-08-31 Кьюрис, Инк. Ингибиторы фосфоинозитид-3-киназ с цинксвязывающей группой
CA2775942A1 (en) * 2009-09-29 2011-04-07 Xcovery Holding Company Llc Pi3k (delta) selective inhibitors
EP2526102B1 (en) 2010-01-22 2017-03-08 Fundación Centro Nacional de Investigaciones Oncológicas Carlos III Inhibitors of PI3 kinase
CA2825028A1 (en) * 2011-02-09 2012-08-16 F. Hoffman-La Roche Ag Heterocyclic compounds as pi3 kinase inhibitors

Also Published As

Publication number Publication date
HUE047144T2 (hu) 2020-04-28
UA117318C2 (uk) 2018-07-10
AU2014413483A1 (en) 2017-03-09
AU2014413483B2 (en) 2019-07-25
PH12017500342A1 (en) 2017-07-17
EA036819B1 (ru) 2020-12-23
CA2959980A1 (en) 2016-06-16
EP3230289A1 (en) 2017-10-18
PT3230289T (pt) 2019-10-30
MA40110B2 (fr) 2020-12-31
NZ729078A (en) 2021-07-30
RS59409B1 (sr) 2019-11-29
PH12017500342B1 (en) 2023-03-17
BR112017005518A2 (pt) 2017-12-05
WO2016092556A1 (en) 2016-06-16
SI3230289T1 (sl) 2019-10-30
CA2959980C (en) 2023-04-25
EA201791294A1 (ru) 2017-11-30
MX2017004782A (es) 2017-07-27
JP6454419B2 (ja) 2019-01-16
CY1122080T1 (el) 2020-11-25
US20170320891A1 (en) 2017-11-09
HRP20192041T1 (hr) 2020-02-07
CN107074873B (zh) 2022-01-07
ES2750268T3 (es) 2020-03-25
MA40110A1 (fr) 2017-12-29
LT3230289T (lt) 2019-10-10
DK3230289T3 (da) 2019-10-28
AP2017009749A0 (en) 2017-02-28
JP2017537139A (ja) 2017-12-14
MY188946A (en) 2022-01-14
KR102328921B1 (ko) 2021-11-19
IL252254B (en) 2019-08-29
PL3230289T3 (pl) 2020-03-31
KR20170090434A (ko) 2017-08-07
US10106554B2 (en) 2018-10-23
BR112017005518B1 (pt) 2022-11-29
CO2017002266A2 (es) 2017-05-31
CN107074873A (zh) 2017-08-18
ZA201701036B (en) 2019-06-26
EP3230289B1 (en) 2019-08-14
SG11201702162PA (en) 2017-04-27
IL252254A0 (en) 2017-07-31

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