SMT201700295T1 - Bacterial host strain expressing recombinant dsbc and having reduced tsp activity - Google Patents

Bacterial host strain expressing recombinant dsbc and having reduced tsp activity

Info

Publication number: SMT201700295T1
Authority: SM; San Marino
Prior art keywords: bacterial host; host strain; expressing recombinant; strain expressing; recombinant dsbc
Prior art date: 2010-01-14

Application number

SM20170295T

Other languages

Italian (it)

Inventor

Mark Ellis

David Paul Humphreys

Original Assignee

Ucb Biopharma Sprl

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2010-01-14

Filing date

2011-01-13

Publication date

2017-07-18

2011-01-13 Application filed by Ucb Biopharma Sprl filed Critical Ucb Biopharma Sprl

2017-07-18 Publication of SMT201700295T1 publication Critical patent/SMT201700295T1/en

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/70—Vectors or expression systems specially adapted for E. coli
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
- C07K14/245—Escherichia (G)
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/241—Tumor Necrosis Factors
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/90—Isomerases (5.)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y503/00—Intramolecular oxidoreductases (5.3)
- C12Y503/04—Intramolecular oxidoreductases (5.3) transposing S-S bonds (5.3.4)
- C12Y503/04001—Protein disulfide-isomerase (5.3.4.1), i.e. disufide bond-forming enzyme
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
- C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Genetics & Genomics (AREA)
Biochemistry (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Zoology (AREA)
Bioinformatics & Cheminformatics (AREA)
Wood Science & Technology (AREA)
Biophysics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biotechnology (AREA)
General Engineering & Computer Science (AREA)
Biomedical Technology (AREA)
Gastroenterology & Hepatology (AREA)
Microbiology (AREA)
Immunology (AREA)
Tropical Medicine & Parasitology (AREA)
Virology (AREA)
Physics & Mathematics (AREA)
Plant Pathology (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Coloring Foods And Improving Nutritive Qualities (AREA)

SM20170295T 2010-01-14 2011-01-13 Bacterial host strain expressing recombinant dsbc and having reduced tsp activity SMT201700295T1 (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
GBGB1000591.6A GB201000591D0 (en)	2010-01-14	2010-01-14	Bacterial hoist strain
PCT/EP2011/050416 WO2011086139A1 (en)	2010-01-14	2011-01-13	Bacterial host strain expressing recombinant dsbc and having reduced tsp activity
EP11701045.4A EP2523969B1 (en)	2010-01-14	2011-01-13	Bacterial host strain expressing recombinant dsbc and having reduced tsp activity

Publications (1)

Publication Number	Publication Date
SMT201700295T1 true SMT201700295T1 (en)	2017-07-18

Family

ID=42028361

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SM20170295T SMT201700295T1 (en)	2010-01-14	2011-01-13	Bacterial host strain expressing recombinant dsbc and having reduced tsp activity

Country Status (23)

Country	Link
US (2)	US8969038B2 (en)
EP (1)	EP2523969B1 (en)
JP (1)	JP5960608B2 (en)
KR (1)	KR101729361B1 (en)
CN (2)	CN104328079A (en)
AU (2)	AU2011206587A1 (en)
CA (1)	CA2786336C (en)
CY (1)	CY1118990T1 (en)
DK (1)	DK2523969T3 (en)
ES (1)	ES2627826T3 (en)
GB (1)	GB201000591D0 (en)
HK (1)	HK1206785A1 (en)
HR (1)	HRP20170852T1 (en)
HU (1)	HUE033555T2 (en)
LT (1)	LT2523969T (en)
ME (1)	ME02752B (en)
PL (1)	PL2523969T3 (en)
PT (1)	PT2523969T (en)
RS (1)	RS56159B1 (en)
SG (1)	SG182280A1 (en)
SI (1)	SI2523969T1 (en)
SM (1)	SMT201700295T1 (en)
WO (1)	WO2011086139A1 (en)

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HUE040306T2 (en)	2009-09-24	2019-03-28	Ucb Biopharma Sprl	Bacterial strain for expression of recombinant protein containing protease-deficient but chaperon-active DEGP and gene-cleaved TSP and PTR genes
GB201000587D0 (en)	2010-01-14	2010-03-03	Ucb Pharma Sa	Bacterial hoist strain
GB201000590D0 (en)	2010-01-14	2010-03-03	Ucb Pharma Sa	Bacterial host strain
GB201000591D0 (en) *	2010-01-14	2010-03-03	Ucb Pharma Sa	Bacterial hoist strain
GB201001791D0 (en)	2010-02-03	2010-03-24	Ucb Pharma Sa	Process for obtaining antibodies
GB201012599D0 (en)	2010-07-27	2010-09-08	Ucb Pharma Sa	Process for purifying proteins
EA031449B1 (en)	2011-07-13	2019-01-31	Юсб Фарма, С.А.	BACTERIAL HOST STRAIN EXPRESSING RECOMBINANT DsbC
EP2546267A1 (en) *	2011-07-13	2013-01-16	UCB Pharma S.A.	Bacterial host strain expressing recombinant DsbC
GB201208367D0 (en)	2012-05-14	2012-06-27	Ucb Pharma Sa	Biological product
US11306328B2 (en)	2013-07-26	2022-04-19	President And Fellows Of Harvard College	Genome engineering
US10358460B2 (en)	2014-12-22	2019-07-23	Ucb Biopharma Sprl	Protein manufacture
BR112018015259A2 (en)	2016-01-27	2018-12-18	Medimmune Llc	Methods for preparing antibodies with a defined glycosylation standard
EP4467565A3 (en)	2016-12-21	2025-03-12	Amgen Inc.	Anti-tnf alpha antibody formulations
WO2019193418A1 (en)	2018-04-05	2019-10-10	Bio-Rad Abd Serotec Gmbh	Display systems for proteins of interest
SG11202104104VA (en) *	2018-11-05	2021-05-28	Genentech Inc	Methods of producing two chain proteins in prokaryotic host cells
EP3942079A1 (en)	2019-03-18	2022-01-26	Bio-Rad ABD Serotec GmbH	Protection of spytag-containing periplasmic fusion proteins from protease tsp and ompt degradation
PL4010500T3 (en) *	2019-08-05	2025-06-23	Wacker Chemie Ag	Bacterial strain for releasing a recombinant protein in a fermentation method

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HUE040306T2 (en)	2009-09-24	2019-03-28	Ucb Biopharma Sprl	Bacterial strain for expression of recombinant protein containing protease-deficient but chaperon-active DEGP and gene-cleaved TSP and PTR genes
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GB201000588D0 (en)	2010-01-14	2010-03-03	Ucb Pharma Sa	Bacterial host strain
GB201000587D0 (en)	2010-01-14	2010-03-03	Ucb Pharma Sa	Bacterial hoist strain
GB201000591D0 (en) *	2010-01-14	2010-03-03	Ucb Pharma Sa	Bacterial hoist strain
GB201000590D0 (en)	2010-01-14	2010-03-03	Ucb Pharma Sa	Bacterial host strain
GB201001791D0 (en)	2010-02-03	2010-03-24	Ucb Pharma Sa	Process for obtaining antibodies
GB201012599D0 (en)	2010-07-27	2010-09-08	Ucb Pharma Sa	Process for purifying proteins
EP2546267A1 (en)	2011-07-13	2013-01-16	UCB Pharma S.A.	Bacterial host strain expressing recombinant DsbC
EA031449B1 (en)	2011-07-13	2019-01-31	Юсб Фарма, С.А.	BACTERIAL HOST STRAIN EXPRESSING RECOMBINANT DsbC
GB201208367D0 (en)	2012-05-14	2012-06-27	Ucb Pharma Sa	Biological product

2010
- 2010-01-14 GB GBGB1000591.6A patent/GB201000591D0/en not_active Ceased
2011
- 2011-01-13 SI SI201131205A patent/SI2523969T1/en unknown
- 2011-01-13 ME MEP-2017-127A patent/ME02752B/en unknown
- 2011-01-13 CN CN201410591520.4A patent/CN104328079A/en active Pending
- 2011-01-13 EP EP11701045.4A patent/EP2523969B1/en active Active
- 2011-01-13 WO PCT/EP2011/050416 patent/WO2011086139A1/en not_active Ceased
- 2011-01-13 KR KR1020127021021A patent/KR101729361B1/en active Active
- 2011-01-13 RS RS20170626A patent/RS56159B1/en unknown
- 2011-01-13 HR HRP20170852TT patent/HRP20170852T1/en unknown
- 2011-01-13 ES ES11701045.4T patent/ES2627826T3/en active Active
- 2011-01-13 DK DK11701045.4T patent/DK2523969T3/en active
- 2011-01-13 PL PL11701045T patent/PL2523969T3/en unknown
- 2011-01-13 LT LTEP11701045.4T patent/LT2523969T/en unknown
- 2011-01-13 SG SG2012047676A patent/SG182280A1/en unknown
- 2011-01-13 PT PT117010454T patent/PT2523969T/en unknown
- 2011-01-13 JP JP2012548441A patent/JP5960608B2/en active Active
- 2011-01-13 CN CN201180005978.1A patent/CN102712679B/en active Active
- 2011-01-13 US US13/522,083 patent/US8969038B2/en active Active
- 2011-01-13 HU HUE11701045A patent/HUE033555T2/en unknown
- 2011-01-13 CA CA2786336A patent/CA2786336C/en active Active
- 2011-01-13 SM SM20170295T patent/SMT201700295T1/en unknown
- 2011-01-13 AU AU2011206587A patent/AU2011206587A1/en not_active Abandoned
2013
- 2013-03-25 HK HK15107468.1A patent/HK1206785A1/en unknown
2015
- 2015-02-27 US US14/633,294 patent/US9493559B2/en active Active
2017
- 2017-04-12 AU AU2017202434A patent/AU2017202434B2/en active Active
- 2017-06-22 CY CY20171100667T patent/CY1118990T1/en unknown

Also Published As

Publication number	Publication date
CN102712679A (en)	2012-10-03
US8969038B2 (en)	2015-03-03
ME02752B (en)	2018-01-20
SI2523969T1 (en)	2017-07-31
US20120288894A1 (en)	2012-11-15
CA2786336C (en)	2018-09-04
JP5960608B2 (en)	2016-08-02
AU2017202434A1 (en)	2017-05-04
CA2786336A1 (en)	2011-07-21
KR101729361B1 (en)	2017-04-21
BR112012016808A2 (en)	2017-06-27
AU2017202434B2 (en)	2019-05-16
CN102712679B (en)	2015-06-03
CN104328079A (en)	2015-02-04
ES2627826T3 (en)	2017-07-31
CY1118990T1 (en)	2018-01-10
JP2013516966A (en)	2013-05-16
US9493559B2 (en)	2016-11-15
HK1206785A1 (en)	2016-01-15
HUE033555T2 (en)	2017-12-28
RS56159B1 (en)	2017-11-30
AU2011206587A1 (en)	2012-07-19
EP2523969A1 (en)	2012-11-21
LT2523969T (en)	2017-06-26
PT2523969T (en)	2017-07-04
US20150166652A1 (en)	2015-06-18
WO2011086139A1 (en)	2011-07-21
KR20120115997A (en)	2012-10-19
PL2523969T3 (en)	2017-09-29
DK2523969T3 (en)	2017-06-12
HRP20170852T1 (en)	2017-08-25
EP2523969B1 (en)	2017-03-22
GB201000591D0 (en)	2010-03-03
SG182280A1 (en)	2012-08-30
HK1176943A1 (en)	2013-08-09

Publication	Publication Date	Title
SI2523969T1 (en)	2017-07-31	Bacterial host strain expressing recombinant dsbc and having reduced tsp activity
IL229947B (en)	2019-10-31	Bacterial host strain expressing recombinant dsbc
ZA201300147B (en)	2015-04-29	Recombinant host cells comprising phosphoketolases
PT2524043E (en)	2015-07-22	Bacterial host strain comprising a mutant spr gene and having reduced tsp activity
EP2569712A4 (en)	2018-01-17	Control system user interface
EP2569436B8 (en)	2019-10-30	Recombinant hcmv and rhcmv vectors and uses thereof
GB2494792B (en)	2016-10-05	Subsea orientation and control system
GB2480940B (en)	2015-10-07	Well control systems and methods
PL2655644T3 (en)	2019-05-31	Improving fermentation processes and by-products
SG10201503428RA (en)	2015-06-29	Data Gathering System
EP2531099A4 (en)	2017-05-03	Data gathering system
SI2523975T1 (en)	2019-10-30	Bacterial host strain comprising a mutant spr gene and a wild-type tsp gene
SG10201606462WA (en)	2016-09-29	Bacterial host strain
EP2551757A4 (en)	2013-01-30	Information interaction method and interface control system
AU2011233911A1 (en)	2012-11-22	Dishwasher and control method thereof
EP2612298A4 (en)	2017-01-04	Co-compression and co-decompression of data values
EP2540175A4 (en)	2017-08-30	Soft and elastic jacket
GB201000589D0 (en)	2010-03-03	Bacterial host strain
GB201000605D0 (en)	2010-03-03	Bacterial host strain
GB201000606D0 (en)	2010-03-03	Bacterial host strain
GB0916822D0 (en)	2009-11-04	Bacterial host strain
GB0916818D0 (en)	2009-11-04	Bacterial host strain
GB0916817D0 (en)	2009-11-04	Bacterial host strain
GB0916821D0 (en)	2009-11-04	Bacterial host strain
GB0922070D0 (en)	2010-02-03	Improved product assembly system and control software