SMT201400114B - Derivati di 2-arilimidazolo come inibitori dell'enzima pde10a - Google Patents

Derivati di 2-arilimidazolo come inibitori dell'enzima pde10a

Info

Publication number: SMT201400114B
Authority: SM; San Marino
Prior art keywords: inhibitors; pde10a enzyme; arylimidazole derivatives; arylimidazole; derivatives
Prior art date: 2009-12-17

Application number

SM201400114T

Other languages

English (en)

Inventor

Ask Puschl

John Paul Kilburn

Morten Langgard

Jan Kehler

Mauro Marigo

Jacob Nielsen

Original Assignee

Lundbeck & Co As H

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2009-12-17

Filing date

2014-08-18

Publication date

2014-11-10

2014-08-18 Application filed by Lundbeck & Co As H filed Critical Lundbeck & Co As H

2014-11-10 Publication of SMT201400114B publication Critical patent/SMT201400114B/it

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4196—1,2,4-Triazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Psychiatry (AREA)
Addiction (AREA)
Epidemiology (AREA)
Psychology (AREA)
Hospice & Palliative Care (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

SM201400114T 2009-12-17 2014-08-18 Derivati di 2-arilimidazolo come inibitori dell'enzima pde10a SMT201400114B (it)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US28732409P	2009-12-17	2009-12-17
DKPA200901341		2009-12-17
PCT/DK2010/050343 WO2011072696A1 (en)	2009-12-17	2010-12-15	2-arylimidazole derivatives as pde10a enzyme inhibitors

Publications (1)

Publication Number	Publication Date
SMT201400114B true SMT201400114B (it)	2014-11-10

Family

ID=44246810

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SM201400114T SMT201400114B (it)	2009-12-17	2014-08-18	Derivati di 2-arilimidazolo come inibitori dell'enzima pde10a

Country Status (34)

Country	Link
US (2)	US8501797B2 (it)
EP (1)	EP2513105B1 (it)
JP (1)	JP5698761B2 (it)
KR (1)	KR101777889B1 (it)
CN (1)	CN102753551B (it)
AR (1)	AR079498A1 (it)
AU (1)	AU2010333437B2 (it)
CA (1)	CA2783727C (it)
CO (1)	CO6612246A2 (it)
CR (1)	CR20120317A (it)
CY (1)	CY1115278T1 (it)
DK (1)	DK2513105T3 (it)
DO (1)	DOP2012000168A (it)
EA (1)	EA021415B1 (it)
ES (1)	ES2484692T3 (it)
GE (1)	GEP20156242B (it)
GT (1)	GT201200180A (it)
HR (1)	HRP20140632T1 (it)
MA (1)	MA33924B1 (it)
MX (1)	MX2012007144A (it)
MY (1)	MY158202A (it)
NZ (1)	NZ600416A (it)
PH (1)	PH12012501223A1 (it)
PL (1)	PL2513105T3 (it)
PT (1)	PT2513105E (it)
RS (1)	RS53413B (it)
SG (1)	SG181536A1 (it)
SI (1)	SI2513105T1 (it)
SM (1)	SMT201400114B (it)
TN (1)	TN2012000287A1 (it)
TW (1)	TWI481607B (it)
UA (1)	UA107817C2 (it)
WO (1)	WO2011072696A1 (it)
ZA (1)	ZA201204418B (it)

Families Citing this family (17)

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TWI481607B (zh)	2009-12-17	2015-04-21	Lundbeck & Co As H	作為ｐｄｅ１０ａ酵素抑制劑的２－芳基咪唑衍生物
TWI485151B (zh)	2009-12-17	2015-05-21	Lundbeck & Co As H	作為ｐｄｅ１０ａ酵素抑制劑之雜芳香族苯基咪唑衍生物
TWI487705B (zh)	2009-12-17	2015-06-11	Lundbeck & Co As H	作為ｐｄｅ１０ａ酵素抑制劑之雜芳香族芳基三唑衍生物
JO3089B1 (ar) *	2010-11-19	2017-03-15	H Lundbeck As	مشتقات ايميدازول كمثبطات لانزيمات pde10a
PT2651918T (pt)	2010-12-17	2017-10-17	Novartis Ag	Formas cristalinas de 5-cloro-n2-(2-isopropoxi-5-metil-4-piperidin-4-il-fenil)-n4-[2-(propano-2-sulfonil)-fenil]-pirimidin-2,4-diamina
EP2651902B1 (en)	2010-12-17	2017-11-08	Reata Pharmaceuticals, Inc.	Pyrazolyl and pyrimidinyl tricyclic enones as antioxidant inflammation modulators
CA2824047C (en)	2011-01-11	2019-06-18	Sunovion Pharmaceuticals Inc.	Heteroaryl compounds and methods of use thereof
US8772316B2 (en)	2011-02-18	2014-07-08	Allergan, Inc.	Substituted 6,7-dialkoxy-3-isoquinolinol derivatives as inhibitors of phosphodiesterase 10 (PDE10A)
US9938269B2 (en) *	2011-06-30	2018-04-10	Abbvie Inc.	Inhibitor compounds of phosphodiesterase type 10A
MY157301A (en) *	2011-08-25	2016-05-31	Merck Sharp & Dohme	Pyrimidine pde10 inhibitors
TWI570124B (zh)	2011-12-21	2017-02-11	Ｈ朗德貝克公司	作為ｐｄｅ１０ａ酵素抑制劑的喹啉衍生物
WO2013107856A1 (en) *	2012-01-20	2013-07-25	H. Lundbeck A/S	Imidazole derivatives as pde10a enzyme inhibitors
WO2013127817A1 (en)	2012-02-27	2013-09-06	H. Lundbeck A/S	Imidazole derivatives as pde10a enzyme inhibitors
WO2014071044A1 (en)	2012-11-01	2014-05-08	Allergan, Inc.	Substituted 6,7-dialkoxy-3-isoquinoline derivatives as inhibitors of phosphodiesterase 10 (pde10a)
US9200016B2 (en)	2013-12-05	2015-12-01	Allergan, Inc.	Substituted 6, 7-dialkoxy-3-isoquinoline derivatives as inhibitors of phosphodiesterase 10 (PDE 10A)
CN109923116B (zh) *	2016-11-02	2022-12-06	詹森药业有限公司	作为pde2抑制剂的[1,2,4]三唑并[1,5-a]嘧啶衍生物
GB202002926D0 (en) *	2020-02-28	2020-04-15	Benevolentai Tech Limited	Compositions and uses thereof

Family Cites Families (24)

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GB8307865D0 (en)	1983-03-22	1983-04-27	Fujisawa Pharmaceutical Co	Benzimidazole derivatives
US5571775A (en)	1994-07-11	1996-11-05	Dowelanco	N-aryl[1,2,4]triazolo[1,5-a]pyridine-2-sulfonamide herbicides
IL149106A0 (en)	2001-04-20	2002-11-10	Pfizer Prod Inc	Therapeutic use of selective pde10 inhibitors
US20030032579A1 (en)	2001-04-20	2003-02-13	Pfizer Inc.	Therapeutic use of selective PDE10 inhibitors
FR2824065A1 (fr)	2001-04-26	2002-10-31	Neuro3D	Composes inhibiteurs des phosphodiesterases des nucleotides cycliques, preparation et utilisations
US20040152699A1 (en) *	2002-08-09	2004-08-05	Astrazeneca And Nps Pharmaceuticals, Inc.	Compounds
DE60324449D1 (de)	2002-10-30	2008-12-11	Via Pharmaceuticals Inc	Inhibitoren der phosphodiesterase der zyklischen n, und deren verwendung in therapie
UA86591C2 (ru)	2003-06-30	2009-05-12	Алтана Фарма Аг	Пирролодигидроизохинолины как ингибиторы pde10, фармацевтическая композиция на их основе
DE602004022415D1 (de)	2003-06-30	2009-09-17	Nycomed Gmbh	Pyrrolo-dihydroisochinolin-derivate als pde10-inhibitoren
US20070032404A1 (en)	2003-07-31	2007-02-08	Bayer Pharmaceuticals Corporation	Methods for treating diabetes and related disorders using pde10a inhibitors
WO2005014588A1 (en)	2003-08-01	2005-02-17	Argenta Discovery Limited	Substituted thienyl-hydroxamic acids having histone deacetylase activity
EP1723134A2 (en)	2004-02-18	2006-11-22	Pfizer Products Incorporated	Tetrahydroisoquinolinyl derivatives of quinazoline and isoquinoline
FR2870539B1 (fr)	2004-05-19	2006-08-04	Greenpharma Sa Sa	Nouvelles methodes et medicaments
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CA2650976A1 (en) *	2006-05-02	2007-11-15	Pfizer Products Inc.	Bicyclic heteroaryl compounds as pde10 inhibitors
US20080090834A1 (en) *	2006-07-06	2008-04-17	Pfizer Inc	Selective azole pde10a inhibitor compounds
DK2057153T3 (da) *	2006-07-10	2012-10-15	Lundbeck & Co As H	(3-aryl-piperazin-1-yl)-derivater af 6,7 dialkoxyquinazolin, 6,7- dialkoxyphtalazin og 6,7-dialkoxyisoquinolin
JP2010533715A (ja)	2007-07-17	2010-10-28	アムジエン・インコーポレーテツド	複素環系ｐｋｂ調節剤
TWI501965B (zh) *	2008-06-20	2015-10-01	Lundbeck & Co As H	作為ｐｄｅ１０ａ酵素抑制劑之新穎苯基咪唑衍生物
TWI481607B (zh) *	2009-12-17	2015-04-21	Lundbeck & Co As H	作為ｐｄｅ１０ａ酵素抑制劑的２－芳基咪唑衍生物
TWI485151B (zh)	2009-12-17	2015-05-21	Lundbeck & Co As H	作為ｐｄｅ１０ａ酵素抑制劑之雜芳香族苯基咪唑衍生物
TWI487705B (zh) *	2009-12-17	2015-06-11	Lundbeck & Co As H	作為ｐｄｅ１０ａ酵素抑制劑之雜芳香族芳基三唑衍生物

2010
- 2010-12-14 TW TW099143693A patent/TWI481607B/zh not_active IP Right Cessation
- 2010-12-15 PL PL10797990T patent/PL2513105T3/pl unknown
- 2010-12-15 WO PCT/DK2010/050343 patent/WO2011072696A1/en active Application Filing
- 2010-12-15 AU AU2010333437A patent/AU2010333437B2/en not_active Ceased
- 2010-12-15 CN CN201080064084.5A patent/CN102753551B/zh not_active Expired - Fee Related
- 2010-12-15 NZ NZ600416A patent/NZ600416A/xx not_active IP Right Cessation
- 2010-12-15 PT PT107979908T patent/PT2513105E/pt unknown
- 2010-12-15 JP JP2012543476A patent/JP5698761B2/ja not_active Expired - Fee Related
- 2010-12-15 GE GEAP201012787A patent/GEP20156242B/en unknown
- 2010-12-15 RS RS20140371A patent/RS53413B/en unknown
- 2010-12-15 MY MYPI2012002597A patent/MY158202A/en unknown
- 2010-12-15 DK DK10797990.8T patent/DK2513105T3/da active
- 2010-12-15 KR KR1020127015565A patent/KR101777889B1/ko active Active
- 2010-12-15 EP EP10797990.8A patent/EP2513105B1/en active Active
- 2010-12-15 PH PH1/2012/501223A patent/PH12012501223A1/en unknown
- 2010-12-15 MX MX2012007144A patent/MX2012007144A/es active IP Right Grant
- 2010-12-15 MA MA35065A patent/MA33924B1/fr unknown
- 2010-12-15 ES ES10797990.8T patent/ES2484692T3/es active Active
- 2010-12-15 UA UAA201207978A patent/UA107817C2/uk unknown
- 2010-12-15 SI SI201030671T patent/SI2513105T1/sl unknown
- 2010-12-15 CA CA2783727A patent/CA2783727C/en not_active Expired - Fee Related
- 2010-12-15 HR HRP20140632AT patent/HRP20140632T1/hr unknown
- 2010-12-15 US US13/515,325 patent/US8501797B2/en not_active Expired - Fee Related
- 2010-12-15 EA EA201290518A patent/EA021415B1/ru not_active IP Right Cessation
- 2010-12-15 SG SG2012041547A patent/SG181536A1/en unknown
- 2010-12-16 AR ARP100104671A patent/AR079498A1/es unknown
2012
- 2012-06-05 TN TNP2012000287A patent/TN2012000287A1/en unknown
- 2012-06-07 GT GT201200180A patent/GT201200180A/es unknown
- 2012-06-12 CR CR20120317A patent/CR20120317A/es unknown
- 2012-06-15 ZA ZA2012/04418A patent/ZA201204418B/en unknown
- 2012-06-15 CO CO12101119A patent/CO6612246A2/es active IP Right Grant
- 2012-06-15 DO DO2012000168A patent/DOP2012000168A/es unknown
2013
- 2013-06-24 US US13/924,712 patent/US8927738B2/en not_active Expired - Fee Related
2014
- 2014-07-18 CY CY20141100539T patent/CY1115278T1/el unknown
- 2014-08-18 SM SM201400114T patent/SMT201400114B/it unknown

Also Published As

Publication number	Publication date
TN2012000287A1 (en)	2013-12-12
MA33924B1 (fr)	2013-01-02
EP2513105A1 (en)	2012-10-24
US20130289038A1 (en)	2013-10-31
MX2012007144A (es)	2012-07-03
EP2513105B1 (en)	2014-05-14
HK1177739A1 (en)	2013-08-30
SG181536A1 (en)	2012-07-30
CA2783727A1 (en)	2011-06-23
CR20120317A (es)	2012-08-16
AR079498A1 (es)	2012-02-01
CY1115278T1 (el)	2017-01-04
JP5698761B2 (ja)	2015-04-08
CN102753551B (zh)	2014-10-22
US20120302548A1 (en)	2012-11-29
TW201127831A (en)	2011-08-16
HRP20140632T1 (hr)	2014-09-26
US8927738B2 (en)	2015-01-06
GT201200180A (es)	2015-01-16
MY158202A (en)	2016-09-15
KR101777889B1 (ko)	2017-09-12
WO2011072696A1 (en)	2011-06-23
TWI481607B (zh)	2015-04-21
RS53413B (en)	2014-12-31
PL2513105T3 (pl)	2014-09-30
EA201290518A1 (ru)	2013-01-30
ZA201204418B (en)	2013-08-28
AU2010333437A1 (en)	2012-06-21
PT2513105E (pt)	2014-07-31
CN102753551A (zh)	2012-10-24
CO6612246A2 (es)	2013-02-01
SI2513105T1 (sl)	2014-11-28
UA107817C2 (en)	2015-02-25
DOP2012000168A (es)	2012-11-30
JP2013514285A (ja)	2013-04-25
NZ600416A (en)	2013-08-30
KR20120123276A (ko)	2012-11-08
AU2010333437B2 (en)	2016-09-01
ES2484692T3 (es)	2014-08-12
US8501797B2 (en)	2013-08-06
GEP20156242B (en)	2015-02-10
EA021415B1 (ru)	2015-06-30
DK2513105T3 (da)	2014-07-14
CA2783727C (en)	2018-02-20
PH12012501223A1 (en)	2022-10-03

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SMT201400114B (it)	2014-11-10	Derivati di 2-arilimidazolo come inibitori dell'enzima pde10a
SMT201400158B (it)	2015-01-15	Derivati eteroaromatici di fenilimidazolo come inibitori dell'enzima pde10a
NL300938I2 (nl)	2019-01-08	Niraparib tosylaat of niraparib tosylaat monohydraat
SMT201400009B (it)	2014-03-07	Derivati eteroaromatici di ariltriazolo come inibitori dell'enzima pde 10A
SMT201600198B (it)	2016-08-31	Derivati di 1,2,4-triazina-4-ammina
SMT201600220B (it)	2016-08-31	Derivati di eterociclile biciclici come inibitori di fgfr chinasi per uso terapeutico
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