SK316592A3 - Sensor for measuring the quantity of a dissolved component - Google Patents

Sensor for measuring the quantity of a dissolved component Download PDF

Info

Publication number: SK316592A3
Authority: SK; Slovakia
Prior art keywords: sensor; mediator; current collector; bipyridine; measuring
Prior art date: 1991-02-21

Application number

SK3165-92A

Other languages

English (en)

Slovak (sk)

Inventor

Michael Gratzel

David Fraser

Shaik M Zakeeruddin

Jean-Paul Randin

Erik J Frenkel

Original Assignee

Asulab Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-02-21

Filing date

1992-02-19

Publication date

1995-04-12

1992-02-19 Application filed by Asulab Sa filed Critical Asulab Sa

1995-04-12 Publication of SK316592A3 publication Critical patent/SK316592A3/sk

Links

WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims abstract description 48
239000008103 glucose Substances 0.000 claims abstract description 48
102000004190 Enzymes Human genes 0.000 claims abstract description 33
108090000790 Enzymes Proteins 0.000 claims abstract description 33
239000000203 mixture Substances 0.000 claims abstract description 19
230000033116 oxidation-reduction process Effects 0.000 claims abstract description 11
239000003446 ligand Substances 0.000 claims abstract description 6
ROFVEXUMMXZLPA-UHFFFAOYSA-N Bipyridyl Chemical compound N1=CC=CC=C1C1=CC=CC=N1 ROFVEXUMMXZLPA-UHFFFAOYSA-N 0.000 claims abstract description 5
229910052723 transition metal Inorganic materials 0.000 claims abstract 3
150000003624 transition metals Chemical group 0.000 claims abstract 3
108010015776 Glucose oxidase Proteins 0.000 claims description 52
239000004366 Glucose oxidase Substances 0.000 claims description 51
229940116332 glucose oxidase Drugs 0.000 claims description 51
235000019420 glucose oxidase Nutrition 0.000 claims description 51
OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 40
229940088598 enzyme Drugs 0.000 claims description 31
239000000243 solution Substances 0.000 claims description 23
239000004020 conductor Substances 0.000 claims description 18
229910052799 carbon Inorganic materials 0.000 claims description 16
BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 claims description 10
108091003079 Bovine Serum Albumin Proteins 0.000 claims description 7
229940098773 bovine serum albumin Drugs 0.000 claims description 7
238000012545 processing Methods 0.000 claims description 7
SXRSQZLOMIGNAQ-UHFFFAOYSA-N Glutaraldehyde Chemical compound O=CCCCC=O SXRSQZLOMIGNAQ-UHFFFAOYSA-N 0.000 claims description 6
KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium Chemical compound [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 claims description 6
239000000654 additive Substances 0.000 claims description 6
230000000996 additive effect Effects 0.000 claims description 6
229910052762 osmium Inorganic materials 0.000 claims description 6
SYQBFIAQOQZEGI-UHFFFAOYSA-N osmium atom Chemical compound [Os] SYQBFIAQOQZEGI-UHFFFAOYSA-N 0.000 claims description 6
IWYGFISAJFBJKK-UHFFFAOYSA-N 4-methoxy-2-(4-methoxypyridin-2-yl)pyridine;osmium Chemical group [Os].COC1=CC=NC(C=2N=CC=C(OC)C=2)=C1.COC1=CC=NC(C=2N=CC=C(OC)C=2)=C1.COC1=CC=NC(C=2N=CC=C(OC)C=2)=C1 IWYGFISAJFBJKK-UHFFFAOYSA-N 0.000 claims description 5
230000008878 coupling Effects 0.000 claims description 5
238000010168 coupling process Methods 0.000 claims description 5
238000005859 coupling reaction Methods 0.000 claims description 5
229910052697 platinum Inorganic materials 0.000 claims description 5
IMEVSAIFJKKDAP-UHFFFAOYSA-N 4-methoxy-2-(4-methoxypyridin-2-yl)pyridine Chemical compound COC1=CC=NC(C=2N=CC=C(OC)C=2)=C1 IMEVSAIFJKKDAP-UHFFFAOYSA-N 0.000 claims description 4
102000003983 Flavoproteins Human genes 0.000 claims description 4
108010057573 Flavoproteins Proteins 0.000 claims description 4
239000000843 powder Substances 0.000 claims description 4
230000027756 respiratory electron transport chain Effects 0.000 claims description 4
DRGAZIDRYFYHIJ-UHFFFAOYSA-N 2,2':6',2''-terpyridine Chemical compound N1=CC=CC=C1C1=CC=CC(C=2N=CC=CC=2)=N1 DRGAZIDRYFYHIJ-UHFFFAOYSA-N 0.000 claims description 3
PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 claims description 3
229910052737 gold Inorganic materials 0.000 claims description 3
239000010931 gold Substances 0.000 claims description 3
229910044991 metal oxide Inorganic materials 0.000 claims description 3
150000004706 metal oxides Chemical class 0.000 claims description 3
229910052763 palladium Inorganic materials 0.000 claims description 3
108090000854 Oxidoreductases Proteins 0.000 claims description 2
102000004316 Oxidoreductases Human genes 0.000 claims description 2
KJTLSVCANCCWHF-UHFFFAOYSA-N Ruthenium Chemical compound [Ru] KJTLSVCANCCWHF-UHFFFAOYSA-N 0.000 claims description 2
125000003545 alkoxy group Chemical group 0.000 claims description 2
125000004104 aryloxy group Chemical group 0.000 claims description 2
150000001718 carbodiimides Chemical class 0.000 claims description 2
239000008199 coating composition Substances 0.000 claims description 2
229920001940 conductive polymer Polymers 0.000 claims description 2
125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 2
125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 2
229910052707 ruthenium Inorganic materials 0.000 claims description 2
125000000467 secondary amino group Chemical class [H]N([*:1])[*:2] 0.000 claims description 2
229920003169 water-soluble polymer Polymers 0.000 claims description 2
XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims 2
KYBXRGMGABIYAW-UHFFFAOYSA-N 4-methyl-2-(4-methylpyridin-2-yl)pyridine;osmium Chemical compound [Os].CC1=CC=NC(C=2N=CC=C(C)C=2)=C1 KYBXRGMGABIYAW-UHFFFAOYSA-N 0.000 claims 1
229910052742 iron Inorganic materials 0.000 claims 1
125000001302 tertiary amino group Chemical group 0.000 claims 1
229910052720 vanadium Inorganic materials 0.000 claims 1
LEONUFNNVUYDNQ-UHFFFAOYSA-N vanadium atom Chemical compound [V] LEONUFNNVUYDNQ-UHFFFAOYSA-N 0.000 claims 1
DGEZNRSVGBDHLK-UHFFFAOYSA-N [1,10]phenanthroline Chemical compound C1=CN=C2C3=NC=CC=C3C=CC2=C1 DGEZNRSVGBDHLK-UHFFFAOYSA-N 0.000 abstract description 3
JFJNVIPVOCESGZ-UHFFFAOYSA-N 2,3-dipyridin-2-ylpyridine Chemical compound N1=CC=CC=C1C1=CC=CN=C1C1=CC=CC=N1 JFJNVIPVOCESGZ-UHFFFAOYSA-N 0.000 abstract 1
238000001514 detection method Methods 0.000 abstract 1
210000004369 blood Anatomy 0.000 description 32
239000008280 blood Substances 0.000 description 32
238000005259 measurement Methods 0.000 description 30
CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 19
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 17
229910052760 oxygen Inorganic materials 0.000 description 17
239000001301 oxygen Substances 0.000 description 17
238000006243 chemical reaction Methods 0.000 description 13
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 12
238000002474 experimental method Methods 0.000 description 11
238000000034 method Methods 0.000 description 10
230000002829 reductive effect Effects 0.000 description 10
150000001875 compounds Chemical class 0.000 description 9
239000003814 drug Substances 0.000 description 9
230000000694 effects Effects 0.000 description 9
238000005534 hematocrit Methods 0.000 description 9
239000002953 phosphate buffered saline Substances 0.000 description 9
MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 8
235000010323 ascorbic acid Nutrition 0.000 description 8
239000011668 ascorbic acid Substances 0.000 description 8
229960005070 ascorbic acid Drugs 0.000 description 8
229940079593 drug Drugs 0.000 description 8
239000008363 phosphate buffer Substances 0.000 description 8
239000011780 sodium chloride Substances 0.000 description 8
239000007983 Tris buffer Substances 0.000 description 7
NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 6
-1 nickel cyclamate compounds Chemical class 0.000 description 6
ADVGKWPZRIDURE-UHFFFAOYSA-N 2'-Hydroxyacetanilide Chemical compound CC(=O)NC1=CC=CC=C1O ADVGKWPZRIDURE-UHFFFAOYSA-N 0.000 description 5
JJRZOCBKIZXACQ-UHFFFAOYSA-N 4-methoxy-2-(4-methoxypyridin-2-yl)pyridine 4-methyl-2-(4-methylpyridin-2-yl)pyridine osmium Chemical compound [Os].CC1=CC=NC(C=2N=CC=C(C)C=2)=C1.COC1=CC=NC(C=2N=CC=C(OC)C=2)=C1.COC1=CC=NC(C=2N=CC=C(OC)C=2)=C1 JJRZOCBKIZXACQ-UHFFFAOYSA-N 0.000 description 5
WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 description 4
229960001138 acetylsalicylic acid Drugs 0.000 description 4
239000000872 buffer Substances 0.000 description 4
238000001739 density measurement Methods 0.000 description 4
210000002381 plasma Anatomy 0.000 description 4
238000012360 testing method Methods 0.000 description 4
BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 description 3
102000004877 Insulin Human genes 0.000 description 3
108090001061 Insulin Proteins 0.000 description 3
229940075397 calomel Drugs 0.000 description 3
230000001413 cellular effect Effects 0.000 description 3
RCTYPNKXASFOBE-UHFFFAOYSA-M chloromercury Chemical compound [Hg]Cl RCTYPNKXASFOBE-UHFFFAOYSA-M 0.000 description 3
230000002860 competitive effect Effects 0.000 description 3
238000002484 cyclic voltammetry Methods 0.000 description 3
ZOMNIUBKTOKEHS-UHFFFAOYSA-L dimercury dichloride Chemical compound Cl[Hg][Hg]Cl ZOMNIUBKTOKEHS-UHFFFAOYSA-L 0.000 description 3
LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 3
KTWOOEGAPBSYNW-UHFFFAOYSA-N ferrocene Chemical compound [Fe+2].C=1C=C[CH-]C=1.C=1C=C[CH-]C=1 KTWOOEGAPBSYNW-UHFFFAOYSA-N 0.000 description 3
229940125396 insulin Drugs 0.000 description 3
239000000126 substance Substances 0.000 description 3
239000012085 test solution Substances 0.000 description 3
LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 3
ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 description 2
PHOQVHQSTUBQQK-SQOUGZDYSA-N D-glucono-1,5-lactone Chemical compound OC[C@H]1OC(=O)[C@H](O)[C@@H](O)[C@@H]1O PHOQVHQSTUBQQK-SQOUGZDYSA-N 0.000 description 2
KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 2
229930003268 Vitamin C Natural products 0.000 description 2
208000007502 anemia Diseases 0.000 description 2
206010012601 diabetes mellitus Diseases 0.000 description 2
238000009792 diffusion process Methods 0.000 description 2
235000012209 glucono delta-lactone Nutrition 0.000 description 2
229960003681 gluconolactone Drugs 0.000 description 2
229910002804 graphite Inorganic materials 0.000 description 2
239000010439 graphite Substances 0.000 description 2
238000005457 optimization Methods 0.000 description 2
230000003647 oxidation Effects 0.000 description 2
238000007254 oxidation reaction Methods 0.000 description 2
235000011164 potassium chloride Nutrition 0.000 description 2
239000001103 potassium chloride Substances 0.000 description 2
238000011160 research Methods 0.000 description 2
230000002441 reversible effect Effects 0.000 description 2
229910001925 ruthenium oxide Inorganic materials 0.000 description 2
WOCIAKWEIIZHES-UHFFFAOYSA-N ruthenium(iv) oxide Chemical compound O=[Ru]=O WOCIAKWEIIZHES-UHFFFAOYSA-N 0.000 description 2
YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 description 2
229910052709 silver Inorganic materials 0.000 description 2
239000004332 silver Substances 0.000 description 2
150000003623 transition metal compounds Chemical class 0.000 description 2
235000019154 vitamin C Nutrition 0.000 description 2
239000011718 vitamin C Substances 0.000 description 2
WTHJTVKLMSJXEV-UHFFFAOYSA-N 2-(4-aminopyridin-2-yl)pyridin-4-amine Chemical compound NC1=CC=NC(C=2N=CC=C(N)C=2)=C1 WTHJTVKLMSJXEV-UHFFFAOYSA-N 0.000 description 1
JHDFNETXVFHWEE-UHFFFAOYSA-N 2-(4-oxo-1h-pyridin-2-yl)-1h-pyridin-4-one Chemical compound OC1=CC=NC(C=2N=CC=C(O)C=2)=C1 JHDFNETXVFHWEE-UHFFFAOYSA-N 0.000 description 1
MWVTWFVJZLCBMC-UHFFFAOYSA-N 4,4'-bipyridine Chemical compound C1=NC=CC(C=2C=CN=CC=2)=C1 MWVTWFVJZLCBMC-UHFFFAOYSA-N 0.000 description 1
GXOJPKDYSPZAIE-UHFFFAOYSA-N 4-methoxy-2-(4-methoxypyridin-2-yl)pyridine;4-methyl-2-(4-methylpyridin-2-yl)pyridine Chemical compound CC1=CC=NC(C=2N=CC=C(C)C=2)=C1.CC1=CC=NC(C=2N=CC=C(C)C=2)=C1.COC1=CC=NC(C=2N=CC=C(OC)C=2)=C1 GXOJPKDYSPZAIE-UHFFFAOYSA-N 0.000 description 1
JQRMNEIWOYETQU-UHFFFAOYSA-N 4-methoxy-2-(4-methoxypyridin-2-yl)pyridine;4-methyl-2-(4-methylpyridin-2-yl)pyridine Chemical compound CC1=CC=NC(C=2N=CC=C(C)C=2)=C1.COC1=CC=NC(C=2N=CC=C(OC)C=2)=C1.COC1=CC=NC(C=2N=CC=C(OC)C=2)=C1 JQRMNEIWOYETQU-UHFFFAOYSA-N 0.000 description 1
NBPGPQJFYXNFKN-UHFFFAOYSA-N 4-methyl-2-(4-methylpyridin-2-yl)pyridine Chemical compound CC1=CC=NC(C=2N=CC=C(C)C=2)=C1 NBPGPQJFYXNFKN-UHFFFAOYSA-N 0.000 description 1
BSYNRYMUTXBXSQ-FOQJRBATSA-N 59096-14-9 Chemical compound CC(=O)OC1=CC=CC=C1[14C](O)=O BSYNRYMUTXBXSQ-FOQJRBATSA-N 0.000 description 1
241000228245 Aspergillus niger Species 0.000 description 1
YPZRHBJKEMOYQH-UYBVJOGSSA-N FADH2 Chemical compound C1=NC2=C(N)N=CN=C2N1[C@@H]([C@H](O)[C@@H]1O)O[C@@H]1COP(O)(=O)OP(O)(=O)OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C(NC(=O)NC2=O)=C2NC2=C1C=C(C)C(C)=C2 YPZRHBJKEMOYQH-UYBVJOGSSA-N 0.000 description 1
241000233866 Fungi Species 0.000 description 1
241001465754 Metazoa Species 0.000 description 1
BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 description 1
230000002411 adverse Effects 0.000 description 1
150000004054 benzoquinones Chemical class 0.000 description 1
210000000601 blood cell Anatomy 0.000 description 1
230000003197 catalytic effect Effects 0.000 description 1
210000004027 cell Anatomy 0.000 description 1
238000005119 centrifugation Methods 0.000 description 1
238000003776 cleavage reaction Methods 0.000 description 1
239000011248 coating agent Substances 0.000 description 1
238000000576 coating method Methods 0.000 description 1
JNGZXGGOCLZBFB-IVCQMTBJSA-N compound E Chemical compound N([C@@H](C)C(=O)N[C@@H]1C(N(C)C2=CC=CC=C2C(C=2C=CC=CC=2)=N1)=O)C(=O)CC1=CC(F)=CC(F)=C1 JNGZXGGOCLZBFB-IVCQMTBJSA-N 0.000 description 1
125000004122 cyclic group Chemical group 0.000 description 1
238000010586 diagram Methods 0.000 description 1
XQGPKZUNMMFTAL-UHFFFAOYSA-L dipotassium;hydrogen phosphate;trihydrate Chemical compound O.O.O.[K+].[K+].OP([O-])([O-])=O XQGPKZUNMMFTAL-UHFFFAOYSA-L 0.000 description 1
238000011156 evaluation Methods 0.000 description 1
238000000855 fermentation Methods 0.000 description 1
230000004151 fermentation Effects 0.000 description 1
229910021397 glassy carbon Inorganic materials 0.000 description 1
150000002303 glucose derivatives Chemical class 0.000 description 1
201000001421 hyperglycemia Diseases 0.000 description 1
238000000338 in vitro Methods 0.000 description 1
238000001727 in vivo Methods 0.000 description 1
235000000396 iron Nutrition 0.000 description 1
230000002427 irreversible effect Effects 0.000 description 1
230000000670 limiting effect Effects 0.000 description 1
238000004519 manufacturing process Methods 0.000 description 1
239000000463 material Substances 0.000 description 1
239000012528 membrane Substances 0.000 description 1
229910052751 metal Inorganic materials 0.000 description 1
239000002184 metal Substances 0.000 description 1
244000005700 microbiome Species 0.000 description 1
229910000402 monopotassium phosphate Inorganic materials 0.000 description 1
235000019796 monopotassium phosphate Nutrition 0.000 description 1
229910000403 monosodium phosphate Inorganic materials 0.000 description 1
235000019799 monosodium phosphate Nutrition 0.000 description 1
229910052759 nickel Inorganic materials 0.000 description 1
PXHVJJICTQNCMI-UHFFFAOYSA-N nickel Substances [Ni] PXHVJJICTQNCMI-UHFFFAOYSA-N 0.000 description 1
230000003287 optical effect Effects 0.000 description 1
125000002524 organometallic group Chemical group 0.000 description 1
FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 1
DFCXLPXOMCCXKM-UHFFFAOYSA-N phenylmethanesulfonic acid;hydrofluoride Chemical compound F.OS(=O)(=O)CC1=CC=CC=C1 DFCXLPXOMCCXKM-UHFFFAOYSA-N 0.000 description 1
PJNZPQUBCPKICU-UHFFFAOYSA-N phosphoric acid;potassium Chemical compound [K].OP(O)(O)=O PJNZPQUBCPKICU-UHFFFAOYSA-N 0.000 description 1
239000002504 physiological saline solution Substances 0.000 description 1
210000004180 plasmocyte Anatomy 0.000 description 1
229920000128 polypyrrole Polymers 0.000 description 1
238000002360 preparation method Methods 0.000 description 1
102000004169 proteins and genes Human genes 0.000 description 1
108090000623 proteins and genes Proteins 0.000 description 1
150000004053 quinones Chemical class 0.000 description 1
238000006479 redox reaction Methods 0.000 description 1
229960004889 salicylic acid Drugs 0.000 description 1
230000007017 scission Effects 0.000 description 1
AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 description 1
125000001424 substituent group Chemical group 0.000 description 1
238000006467 substitution reaction Methods 0.000 description 1
150000003512 tertiary amines Chemical group 0.000 description 1
210000002700 urine Anatomy 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/001—Enzyme electrodes
- C12Q1/005—Enzyme electrodes involving specific analytes or enzymes
- C12Q1/006—Enzyme electrodes involving specific analytes or enzymes for glucose
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/001—Enzyme electrodes
- C12Q1/004—Enzyme electrodes mediator-assisted
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/817—Enzyme or microbe electrode

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Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Health & Medical Sciences (AREA)
Wood Science & Technology (AREA)
Engineering & Computer Science (AREA)
Zoology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Bioinformatics & Cheminformatics (AREA)
Genetics & Genomics (AREA)
Immunology (AREA)
Microbiology (AREA)
Molecular Biology (AREA)
Physics & Mathematics (AREA)
Biotechnology (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Analytical Chemistry (AREA)
General Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Emergency Medicine (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Investigating Or Analysing Biological Materials (AREA)
Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
Investigating Or Analysing Materials By Optical Means (AREA)
Apparatus Associated With Microorganisms And Enzymes (AREA)
Transmission And Conversion Of Sensor Element Output (AREA)
Steering Control In Accordance With Driving Conditions (AREA)

SK3165-92A 1991-02-21 1992-02-19 Sensor for measuring the quantity of a dissolved component SK316592A3 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FR919102200A FR2673289B1 (fr)	1991-02-21	1991-02-21	Capteur de mesure de la quantite d'un composant en solution.
PCT/CH1992/000034 WO1992014836A1 (fr)	1991-02-21	1992-02-19	Capteur de mesure de la quantite d'un composant en solution

Publications (1)

Publication Number	Publication Date
SK316592A3 true SK316592A3 (en)	1995-04-12

Family

ID=9410039

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SK3165-92A SK316592A3 (en)	1991-02-21	1992-02-19	Sensor for measuring the quantity of a dissolved component

Country Status (14)

Country	Link
US (1)	US5378628A (fi)
EP (1)	EP0526602B1 (fi)
JP (1)	JP2770250B2 (fi)
AT (1)	ATE147107T1 (fi)
AU (1)	AU656360B2 (fi)
BG (1)	BG96988A (fi)
CA (1)	CA2080840C (fi)
DE (1)	DE69216319T2 (fi)
FI (1)	FI924726A0 (fi)
FR (1)	FR2673289B1 (fi)
HU (1)	HU212451B (fi)
PL (1)	PL169972B1 (fi)
SK (1)	SK316592A3 (fi)
WO (1)	WO1992014836A1 (fi)

Families Citing this family (223)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5593852A (en)	1993-12-02	1997-01-14	Heller; Adam	Subcutaneous glucose electrode
JPH04278450A (ja)	1991-03-04	1992-10-05	Adam Heller	バイオセンサー及び分析物を分析する方法
US5710011A (en) *	1992-06-05	1998-01-20	Medisense, Inc.	Mediators to oxidoreductase enzymes
AT397513B (de) *	1992-12-15	1994-04-25	Avl Verbrennungskraft Messtech	Amperometrische enzymelektrode
FR2699170B1 (fr) *	1992-12-15	1995-07-28	Asulab Sa	Complexes d'un métal de transition à ligands 2,2'-bipyridine substitués par au moins un radical ammonium alkyle, leur procédé de fabrication et leur application comme médiateur redox.
FR2701117B1 (fr) *	1993-02-04	1995-03-10	Asulab Sa	Système de mesures électrochimiques à capteur multizones, et son application au dosage du glucose.
CH685458A5 (de) *	1993-03-01	1995-07-14	Disetronic Ag	Sensorarray zur selektiven Feststellung oder Messung mindestens einer Stoffkomponente in einer wässerigen Lösung.
FR2705150B1 (fr) *	1993-05-10	1995-07-21	Asulab Sa	Capteur électrochimique à zones multiples sur disque et son application au dosage du glucose.
FR2710411B1 (fr) *	1993-09-21	1995-11-17	Asulab Sa	Dispositif de mesure pour capteurs multizones amovibles.
US5589326A (en) *	1993-12-30	1996-12-31	Boehringer Mannheim Corporation	Osmium-containing redox mediator
US5968745A (en) *	1995-06-27	1999-10-19	The University Of North Carolina At Chapel Hill	Polymer-electrodes for detecting nucleic acid hybridization and method of use thereof
US6346387B1 (en) *	1995-06-27	2002-02-12	Xanthon, Inc.	Detection of binding reactions using labels detected by mediated catalytic electrochemistry
US6127127A (en) *	1995-06-27	2000-10-03	The University Of North Carolina At Chapel Hill	Monolayer and electrode for detecting a label-bearing target and method of use thereof
US6180346B1 (en)	1995-06-27	2001-01-30	The Universtiy Of North Carolina At Chapel Hill	Electropolymerizable film, and method of making and use thereof
US6387625B1 (en)	1995-06-27	2002-05-14	The University Of North Carolina At Chapel Hill	Monolayer and electrode for detecting a label-bearing target and method of use thereof
US6361951B1 (en) *	1995-06-27	2002-03-26	The University Of North Carolina At Chapel Hill	Electrochemical detection of nucleic acid hybridization
US6132971A (en) *	1995-06-27	2000-10-17	The University Of North Carolina At Chapel Hill	Microelectronic device
US5795453A (en) *	1996-01-23	1998-08-18	Gilmartin; Markas A. T.	Electrodes and metallo isoindole ringed compounds
US5830341A (en) *	1996-01-23	1998-11-03	Gilmartin; Markas A. T.	Electrodes and metallo isoindole ringed compounds
FR2744219B1 (fr) *	1996-01-31	1998-03-20	Asulab Sa	Capteur electrochimique sans calibration
US5708247A (en) *	1996-02-14	1998-01-13	Selfcare, Inc.	Disposable glucose test strips, and methods and compositions for making same
US6241862B1 (en)	1996-02-14	2001-06-05	Inverness Medical Technology, Inc.	Disposable test strips with integrated reagent/blood separation layer
US7112265B1 (en)	1996-02-14	2006-09-26	Lifescan Scotland Limited	Disposable test strips with integrated reagent/blood separation layer
JPH09274010A (ja) *	1996-04-04	1997-10-21	Matsushita Electric Ind Co Ltd	基質の定量法
ATE230115T1 (de)	1996-10-30	2003-01-15	Amira Medical	Sycronisiertes analyttestsystem
EP0958495B1 (en)	1997-02-06	2002-11-13	Therasense, Inc.	Small volume in vitro analyte sensor
GB9711395D0 (en) *	1997-06-04	1997-07-30	Environmental Sensors Ltd	Improvements to electrodes for the measurement of analytes in small samples
US6036924A (en)	1997-12-04	2000-03-14	Hewlett-Packard Company	Cassette of lancet cartridges for sampling blood
US6893552B1 (en)	1997-12-29	2005-05-17	Arrowhead Center, Inc.	Microsensors for glucose and insulin monitoring
US6103033A (en)	1998-03-04	2000-08-15	Therasense, Inc.	Process for producing an electrochemical biosensor
US6134461A (en)	1998-03-04	2000-10-17	E. Heller & Company	Electrochemical analyte
US6391005B1 (en)	1998-03-30	2002-05-21	Agilent Technologies, Inc.	Apparatus and method for penetration with shaft having a sensor for sensing penetration depth
US8480580B2 (en) *	1998-04-30	2013-07-09	Abbott Diabetes Care Inc.	Analyte monitoring device and methods of use
US6949816B2 (en)	2003-04-21	2005-09-27	Motorola, Inc.	Semiconductor component having first surface area for electrically coupling to a semiconductor chip and second surface area for electrically coupling to a substrate, and method of manufacturing same
US8688188B2 (en)	1998-04-30	2014-04-01	Abbott Diabetes Care Inc.	Analyte monitoring device and methods of use
US9066695B2 (en) *	1998-04-30	2015-06-30	Abbott Diabetes Care Inc.	Analyte monitoring device and methods of use
US8465425B2 (en)	1998-04-30	2013-06-18	Abbott Diabetes Care Inc.	Analyte monitoring device and methods of use
US8974386B2 (en)	1998-04-30	2015-03-10	Abbott Diabetes Care Inc.	Analyte monitoring device and methods of use
US6175752B1 (en) *	1998-04-30	2001-01-16	Therasense, Inc.	Analyte monitoring device and methods of use
US8346337B2 (en)	1998-04-30	2013-01-01	Abbott Diabetes Care Inc.	Analyte monitoring device and methods of use
US7001733B1 (en)	1998-05-12	2006-02-21	Rigel Pharmaceuticals, Inc.	Methods and compositions for screening for modulations of IgE synthesis, secretion and switch rearrangement
DE69917258T2 (de)	1998-06-01	2005-07-14	Roche Diagnostics Corp., Indianapolis	Methode und vorrichtung zum elektrochemischen immunoassay mehrerer analyten
US6251260B1 (en)	1998-08-24	2001-06-26	Therasense, Inc.	Potentiometric sensors for analytic determination
US6599408B1 (en)	1998-09-17	2003-07-29	E. I. Du Pont De Nemours And Company	Thick film conductor composition for use in biosensors
US6042751A (en) *	1998-09-17	2000-03-28	E. I. Du Pont De Nemours And Company	Thick film conductor composition for use in biosensors
JP3694424B2 (ja)	1998-09-29	2005-09-14	松下電器産業株式会社	グルコースセンサ
US6591125B1 (en)	2000-06-27	2003-07-08	Therasense, Inc.	Small volume in vitro analyte sensor with diffusible or non-leachable redox mediator
US6338790B1 (en)	1998-10-08	2002-01-15	Therasense, Inc.	Small volume in vitro analyte sensor with diffusible or non-leachable redox mediator
DE69941563D1 (de)	1999-02-23	2009-12-03	Asulab Sa	Elektrochemisches System zur Bestimmung der Blutgerinnungszeit
JP4801301B2 (ja)	1999-06-18	2011-10-26	アボットダイアベティスケアインコーポレイテッド	物質移動が制限された生体内分析物センサー
SE9902608D0 (sv) *	1999-07-06	1999-07-06	Forskarpatent I Syd Ab	Histamine detection and detector
ATE313790T1 (de)	1999-10-05	2006-01-15	Matsushita Electric Ind Co Ltd	Glukosesensor
US6616819B1 (en) *	1999-11-04	2003-09-09	Therasense, Inc.	Small volume in vitro analyte sensor and methods
US20060091006A1 (en) *	1999-11-04	2006-05-04	Yi Wang	Analyte sensor with insertion monitor, and methods
US8268143B2 (en) *	1999-11-15	2012-09-18	Abbott Diabetes Care Inc.	Oxygen-effect free analyte sensor
ES2222252T3 (es)	1999-11-15	2005-02-01	Therasense, Inc.	Complejos de un metal de transicion con ligandos bidentados que tienen un anillo imidazol.
US8444834B2 (en)	1999-11-15	2013-05-21	Abbott Diabetes Care Inc.	Redox polymers for use in analyte monitoring
EP1162453A1 (fr) *	2000-06-07	2001-12-12	Asulab S.A.	Capteur électrochimique à reproductibilité accrue
DE10057832C1 (de) *	2000-11-21	2002-02-21	Hartmann Paul Ag	Blutanalysegerät
US8641644B2 (en) *	2000-11-21	2014-02-04	Sanofi-Aventis Deutschland Gmbh	Blood testing apparatus having a rotatable cartridge with multiple lancing elements and testing means
US6560471B1 (en)	2001-01-02	2003-05-06	Therasense, Inc.	Analyte monitoring device and methods of use
US6627058B1 (en)	2001-01-17	2003-09-30	E. I. Du Pont De Nemours And Company	Thick film conductor composition for use in biosensors
AU2002309528A1 (en) *	2001-04-02	2002-10-15	Therasense, Inc.	Blood glucose tracking apparatus and methods
US8070934B2 (en)	2001-05-11	2011-12-06	Abbott Diabetes Care Inc.	Transition metal complexes with (pyridyl)imidazole ligands
US8226814B2 (en) *	2001-05-11	2012-07-24	Abbott Diabetes Care Inc.	Transition metal complexes with pyridyl-imidazole ligands
US6676816B2 (en)	2001-05-11	2004-01-13	Therasense, Inc.	Transition metal complexes with (pyridyl)imidazole ligands and sensors using said complexes
US9226699B2 (en) *	2002-04-19	2016-01-05	Sanofi-Aventis Deutschland Gmbh	Body fluid sampling module with a continuous compression tissue interface surface
US20070100255A1 (en) *	2002-04-19	2007-05-03	Pelikan Technologies, Inc.	Method and apparatus for body fluid sampling and analyte sensing
JP4209767B2 (ja)	2001-06-12	2009-01-14	ペリカンテクノロジーズインコーポレイテッド	皮膚の性状の一時的変化に対する適応手段を備えた自動最適化形切開器具
ATE450209T1 (de)	2001-06-12	2009-12-15	Pelikan Technologies Inc	Gerät und verfahren zur entnahme von blutproben
US7699791B2 (en)	2001-06-12	2010-04-20	Pelikan Technologies, Inc.	Method and apparatus for improving success rate of blood yield from a fingerstick
US7537571B2 (en)	2001-06-12	2009-05-26	Pelikan Technologies, Inc.	Integrated blood sampling analysis system with multi-use sampling module
JP4149911B2 (ja) *	2001-06-12	2008-09-17	ペリカンテクノロジーズインコーポレイテッド	電気式ランセットアクチュエータ
AU2002348683A1 (en) *	2001-06-12	2002-12-23	Pelikan Technologies, Inc.	Method and apparatus for lancet launching device integrated onto a blood-sampling cartridge
US7981056B2 (en)	2002-04-19	2011-07-19	Pelikan Technologies, Inc.	Methods and apparatus for lancet actuation
US8337419B2 (en)	2002-04-19	2012-12-25	Sanofi-Aventis Deutschland Gmbh	Tissue penetration device
US9795747B2 (en)	2010-06-02	2017-10-24	Sanofi-Aventis Deutschland Gmbh	Methods and apparatus for lancet actuation
US7025774B2 (en)	2001-06-12	2006-04-11	Pelikan Technologies, Inc.	Tissue penetration device
US7344894B2 (en)	2001-10-16	2008-03-18	Agilent Technologies, Inc.	Thermal regulation of fluidic samples within a diagnostic cartridge
US6997343B2 (en)	2001-11-14	2006-02-14	Hypoguard Limited	Sensor dispensing device
US8221334B2 (en) *	2002-04-19	2012-07-17	Sanofi-Aventis Deutschland Gmbh	Method and apparatus for penetrating tissue
US8784335B2 (en) *	2002-04-19	2014-07-22	Sanofi-Aventis Deutschland Gmbh	Body fluid sampling device with a capacitive sensor
AU2003231749A1 (en)	2002-04-19	2003-11-03	Pelikan Technologies, Inc.	Device and method for variable speed lancet
US7141058B2 (en)	2002-04-19	2006-11-28	Pelikan Technologies, Inc.	Method and apparatus for a body fluid sampling device using illumination
US7371247B2 (en)	2002-04-19	2008-05-13	Pelikan Technologies, Inc	Method and apparatus for penetrating tissue
US7374544B2 (en)	2002-04-19	2008-05-20	Pelikan Technologies, Inc.	Method and apparatus for penetrating tissue
US7909778B2 (en)	2002-04-19	2011-03-22	Pelikan Technologies, Inc.	Method and apparatus for penetrating tissue
US8360992B2 (en) *	2002-04-19	2013-01-29	Sanofi-Aventis Deutschland Gmbh	Method and apparatus for penetrating tissue
US8579831B2 (en)	2002-04-19	2013-11-12	Sanofi-Aventis Deutschland Gmbh	Method and apparatus for penetrating tissue
US7901362B2 (en)	2002-04-19	2011-03-08	Pelikan Technologies, Inc.	Method and apparatus for penetrating tissue
US7563232B2 (en)	2002-04-19	2009-07-21	Pelikan Technologies, Inc.	Method and apparatus for penetrating tissue
US7892183B2 (en) *	2002-04-19	2011-02-22	Pelikan Technologies, Inc.	Method and apparatus for body fluid sampling and analyte sensing
US7582099B2 (en)	2002-04-19	2009-09-01	Pelikan Technologies, Inc	Method and apparatus for penetrating tissue
US7648468B2 (en) *	2002-04-19	2010-01-19	Pelikon Technologies, Inc.	Method and apparatus for penetrating tissue
US7674232B2 (en) *	2002-04-19	2010-03-09	Pelikan Technologies, Inc.	Method and apparatus for penetrating tissue
US7491178B2 (en) *	2002-04-19	2009-02-17	Pelikan Technologies, Inc.	Method and apparatus for penetrating tissue
US9795334B2 (en) *	2002-04-19	2017-10-24	Sanofi-Aventis Deutschland Gmbh	Method and apparatus for penetrating tissue
US7892185B2 (en)	2002-04-19	2011-02-22	Pelikan Technologies, Inc.	Method and apparatus for body fluid sampling and analyte sensing
US7244265B2 (en) *	2002-04-19	2007-07-17	Pelikan Technologies, Inc.	Method and apparatus for penetrating tissue
US7229458B2 (en)	2002-04-19	2007-06-12	Pelikan Technologies, Inc.	Method and apparatus for penetrating tissue
US7547287B2 (en)	2002-04-19	2009-06-16	Pelikan Technologies, Inc.	Method and apparatus for penetrating tissue
US7410468B2 (en) *	2002-04-19	2008-08-12	Pelikan Technologies, Inc.	Method and apparatus for penetrating tissue
US9314194B2 (en)	2002-04-19	2016-04-19	Sanofi-Aventis Deutschland Gmbh	Tissue penetration device
US7331931B2 (en) *	2002-04-19	2008-02-19	Pelikan Technologies, Inc.	Method and apparatus for penetrating tissue
US7485128B2 (en)	2002-04-19	2009-02-03	Pelikan Technologies, Inc.	Method and apparatus for penetrating tissue
US7175642B2 (en)	2002-04-19	2007-02-13	Pelikan Technologies, Inc.	Methods and apparatus for lancet actuation
US7524293B2 (en) *	2002-04-19	2009-04-28	Pelikan Technologies, Inc.	Method and apparatus for penetrating tissue
US8702624B2 (en) *	2006-09-29	2014-04-22	Sanofi-Aventis Deutschland Gmbh	Analyte measurement device with a single shot actuator
US7232451B2 (en)	2002-04-19	2007-06-19	Pelikan Technologies, Inc.	Method and apparatus for penetrating tissue
US7717863B2 (en) *	2002-04-19	2010-05-18	Pelikan Technologies, Inc.	Method and apparatus for penetrating tissue
US20070142748A1 (en) *	2002-04-19	2007-06-21	Ajay Deshmukh	Tissue penetration device
US7226461B2 (en)	2002-04-19	2007-06-05	Pelikan Technologies, Inc.	Method and apparatus for a multi-use body fluid sampling device with sterility barrier release
US8267870B2 (en) *	2002-04-19	2012-09-18	Sanofi-Aventis Deutschland Gmbh	Method and apparatus for body fluid sampling with hybrid actuation
US7291117B2 (en)	2002-04-19	2007-11-06	Pelikan Technologies, Inc.	Method and apparatus for penetrating tissue
US7297122B2 (en)	2002-04-19	2007-11-20	Pelikan Technologies, Inc.	Method and apparatus for penetrating tissue
US7976476B2 (en)	2002-04-19	2011-07-12	Pelikan Technologies, Inc.	Device and method for variable speed lancet
US20040067481A1 (en) *	2002-06-12	2004-04-08	Leslie Leonard	Thermal sensor for fluid detection
US7250095B2 (en)	2002-07-11	2007-07-31	Hypoguard Limited	Enzyme electrodes and method of manufacture
US7381184B2 (en)	2002-11-05	2008-06-03	Abbott Diabetes Care Inc.	Sensor inserter assembly
AU2003297205A1 (en) *	2002-12-13	2004-07-09	Pelikan Technologies, Inc.	Method and apparatus for measuring analytes
US7265881B2 (en) *	2002-12-20	2007-09-04	Hewlett-Packard Development Company, L.P.	Method and apparatus for measuring assembly and alignment errors in sensor assemblies
US8574895B2 (en)	2002-12-30	2013-11-05	Sanofi-Aventis Deutschland Gmbh	Method and apparatus using optical techniques to measure analyte levels
EP1578262A4 (en)	2002-12-31	2007-12-05	Therasense Inc	CONTINUOUS BLOOD SUGAR MONITORING SYSTEM AND USE METHOD
US7264139B2 (en)	2003-01-14	2007-09-04	Hypoguard Limited	Sensor dispensing device
US7205153B2 (en)	2003-04-11	2007-04-17	Applied Materials, Inc.	Analytical reagent for acid copper sulfate solutions
DE602004028463D1 (de)	2003-05-30	2010-09-16	Pelikan Technologies Inc	Verfahren und vorrichtung zur injektion von flüssigkeit
EP1633235B1 (en) *	2003-06-06	2014-05-21	Sanofi-Aventis Deutschland GmbH	Apparatus for body fluid sampling and analyte sensing
US8066639B2 (en)	2003-06-10	2011-11-29	Abbott Diabetes Care Inc.	Glucose measuring device for use in personal area network
WO2006001797A1 (en)	2004-06-14	2006-01-05	Pelikan Technologies, Inc.	Low pain penetrating
WO2004112602A1 (en)	2003-06-13	2004-12-29	Pelikan Technologies, Inc.	Method and apparatus for a point of care device
US7306641B2 (en) *	2003-09-12	2007-12-11	Hewlett-Packard Development Company, L.P.	Integral fuel cartridge and filter
WO2005033659A2 (en)	2003-09-29	2005-04-14	Pelikan Technologies, Inc.	Method and apparatus for an improved sample capture device
EP1680014A4 (en)	2003-10-14	2009-01-21	Pelikan Technologies Inc	METHOD AND APPARATUS PROVIDING A VARIABLE USER INTERFACE
USD914881S1 (en)	2003-11-05	2021-03-30	Abbott Diabetes Care Inc.	Analyte sensor electronic mount
US7160245B2 (en) *	2003-11-17	2007-01-09	Virginijus Burneikis	Method and device for umbilicus protection during abdominal surgery
US7822454B1 (en) *	2005-01-03	2010-10-26	Pelikan Technologies, Inc.	Fluid sampling device with improved analyte detecting member configuration
US8668656B2 (en)	2003-12-31	2014-03-11	Sanofi-Aventis Deutschland Gmbh	Method and apparatus for improving fluidic flow and sample capture
CA2556331A1 (en)	2004-02-17	2005-09-29	Therasense, Inc.	Method and system for providing data communication in continuous glucose monitoring and management system
EP1751533A2 (en) *	2004-05-14	2007-02-14	Bayer Healthcare, LLC	Voltammetric systems for assaying biological analytes
WO2006011062A2 (en) *	2004-05-20	2006-02-02	Albatros Technologies Gmbh & Co. Kg	Printable hydrogel for biosensors
EP3059580A1 (en)	2004-05-21	2016-08-24	Agamatrix, Inc.	Electrochemical cell device for electrochemical measurement
US9775553B2 (en) *	2004-06-03	2017-10-03	Sanofi-Aventis Deutschland Gmbh	Method and apparatus for a fluid sampling device
WO2005120365A1 (en)	2004-06-03	2005-12-22	Pelikan Technologies, Inc.	Method and apparatus for a fluid sampling device
US7308164B1 (en)	2004-09-16	2007-12-11	The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration	Method for texturing surfaces of optical fiber sensors used for blood glucose monitoring
US10226207B2 (en)	2004-12-29	2019-03-12	Abbott Diabetes Care Inc.	Sensor inserter having introducer
US8333714B2 (en)	2006-09-10	2012-12-18	Abbott Diabetes Care Inc.	Method and system for providing an integrated analyte sensor insertion device and data processing unit
US20110190603A1 (en) *	2009-09-29	2011-08-04	Stafford Gary A	Sensor Inserter Having Introducer
US20070027381A1 (en) *	2005-07-29	2007-02-01	Therasense, Inc.	Inserter and methods of use
US20090105569A1 (en)	2006-04-28	2009-04-23	Abbott Diabetes Care, Inc.	Introducer Assembly and Methods of Use
US7697967B2 (en)	2005-12-28	2010-04-13	Abbott Diabetes Care Inc.	Method and apparatus for providing analyte sensor insertion
US9398882B2 (en) *	2005-09-30	2016-07-26	Abbott Diabetes Care Inc.	Method and apparatus for providing analyte sensor and data processing device
US7731657B2 (en)	2005-08-30	2010-06-08	Abbott Diabetes Care Inc.	Analyte sensor introducer and methods of use
US7883464B2 (en)	2005-09-30	2011-02-08	Abbott Diabetes Care Inc.	Integrated transmitter unit and sensor introducer mechanism and methods of use
US8613703B2 (en)	2007-05-31	2013-12-24	Abbott Diabetes Care Inc.	Insertion devices and methods
US9572534B2 (en)	2010-06-29	2017-02-21	Abbott Diabetes Care Inc.	Devices, systems and methods for on-skin or on-body mounting of medical devices
US20110054275A1 (en) *	2009-08-31	2011-03-03	Abbott Diabetes Care Inc.	Mounting Unit Having a Sensor and Associated Circuitry
US9259175B2 (en) *	2006-10-23	2016-02-16	Abbott Diabetes Care, Inc.	Flexible patch for fluid delivery and monitoring body analytes
US9788771B2 (en)	2006-10-23	2017-10-17	Abbott Diabetes Care Inc.	Variable speed sensor insertion devices and methods of use
US8512243B2 (en)	2005-09-30	2013-08-20	Abbott Diabetes Care Inc.	Integrated introducer and transmitter assembly and methods of use
US8571624B2 (en) *	2004-12-29	2013-10-29	Abbott Diabetes Care Inc.	Method and apparatus for mounting a data transmission device in a communication system
US9351669B2 (en)	2009-09-30	2016-05-31	Abbott Diabetes Care Inc.	Interconnect for on-body analyte monitoring device
US9743862B2 (en)	2011-03-31	2017-08-29	Abbott Diabetes Care Inc.	Systems and methods for transcutaneously implanting medical devices
US20110060196A1 (en) *	2009-08-31	2011-03-10	Abbott Diabetes Care Inc.	Flexible Mounting Unit and Cover for a Medical Device
US20080214917A1 (en) *	2004-12-30	2008-09-04	Dirk Boecker	Method and apparatus for analyte measurement test time
US8652831B2 (en)	2004-12-30	2014-02-18	Sanofi-Aventis Deutschland Gmbh	Method and apparatus for analyte measurement test time
US20060184065A1 (en) *	2005-02-10	2006-08-17	Ajay Deshmukh	Method and apparatus for storing an analyte sampling and measurement device
US8112240B2 (en) *	2005-04-29	2012-02-07	Abbott Diabetes Care Inc.	Method and apparatus for providing leak detection in data monitoring and management systems
DE602005023433D1 (de)	2005-07-07	2010-10-21	Asulab Sa	System zur differenziellen Bestimmung der Menge eines proteolytischen Enzyms in einer Körperflüssigkeit
US7851222B2 (en) *	2005-07-26	2010-12-14	Applied Materials, Inc.	System and methods for measuring chemical concentrations of a plating solution
US9521968B2 (en) *	2005-09-30	2016-12-20	Abbott Diabetes Care Inc.	Analyte sensor retention mechanism and methods of use
US20070191736A1 (en) *	2005-10-04	2007-08-16	Don Alden	Method for loading penetrating members in a collection device
US20070276290A1 (en) *	2005-10-04	2007-11-29	Dirk Boecker	Tissue Penetrating Apparatus
US20090054747A1 (en) *	2005-10-31	2009-02-26	Abbott Diabetes Care, Inc.	Method and system for providing analyte sensor tester isolation
US7766829B2 (en)	2005-11-04	2010-08-03	Abbott Diabetes Care Inc.	Method and system for providing basal profile modification in analyte monitoring and management systems
CA2636034A1 (en)	2005-12-28	2007-10-25	Abbott Diabetes Care Inc.	Medical device insertion
US11298058B2 (en)	2005-12-28	2022-04-12	Abbott Diabetes Care Inc.	Method and apparatus for providing analyte sensor insertion
US7885698B2 (en)	2006-02-28	2011-02-08	Abbott Diabetes Care Inc.	Method and system for providing continuous calibration of implantable analyte sensors
US8226891B2 (en)	2006-03-31	2012-07-24	Abbott Diabetes Care Inc.	Analyte monitoring devices and methods therefor
US7620438B2 (en)	2006-03-31	2009-11-17	Abbott Diabetes Care Inc.	Method and system for powering an electronic device
US20090054749A1 (en) *	2006-05-31	2009-02-26	Abbott Diabetes Care, Inc.	Method and System for Providing Data Transmission in a Data Management System
US20080071158A1 (en) *	2006-06-07	2008-03-20	Abbott Diabetes Care, Inc.	Analyte monitoring system and method
US7382944B1 (en)	2006-07-14	2008-06-03	The United States Of America As Represented By The Administration Of The National Aeronautics And Space Administration	Protective coating and hyperthermal atomic oxygen texturing of optical fibers used for blood glucose monitoring
GB0616566D0 (en) *	2006-08-19	2006-09-27	Rolls Royce Plc	An alloy and method of treating titanium aluminide
US9112447B2 (en) *	2006-11-03	2015-08-18	Solera Laboratories, Inc.	Nano power cell and method of use
US8319092B1 (en)	2006-11-03	2012-11-27	Solera Laboratories, Inc.	Nano power cell and method of use
US8930203B2 (en)	2007-02-18	2015-01-06	Abbott Diabetes Care Inc.	Multi-function analyte test device and methods therefor
US8732188B2 (en)	2007-02-18	2014-05-20	Abbott Diabetes Care Inc.	Method and system for providing contextual based medication dosage determination
US8123686B2 (en)	2007-03-01	2012-02-28	Abbott Diabetes Care Inc.	Method and apparatus for providing rolling data in communication systems
US8456301B2 (en)	2007-05-08	2013-06-04	Abbott Diabetes Care Inc.	Analyte monitoring system and methods
US20080281179A1 (en) *	2007-05-08	2008-11-13	Abbott Diabetes Care, Inc.	Analyte monitoring system and methods
US7928850B2 (en)	2007-05-08	2011-04-19	Abbott Diabetes Care Inc.	Analyte monitoring system and methods
US8461985B2 (en) *	2007-05-08	2013-06-11	Abbott Diabetes Care Inc.	Analyte monitoring system and methods
US8665091B2 (en)	2007-05-08	2014-03-04	Abbott Diabetes Care Inc.	Method and device for determining elapsed sensor life
US8182917B2 (en) *	2008-03-20	2012-05-22	The United States Of America, As Represented By The Secretary Of The Navy	Reduced graphene oxide film
WO2009126900A1 (en)	2008-04-11	2009-10-15	Pelikan Technologies, Inc.	Method and apparatus for analyte detecting device
US8637194B2 (en)	2008-09-02	2014-01-28	Bio-Nano Power, Llc	Bio-nano power cells and their uses
US20100187132A1 (en) *	2008-12-29	2010-07-29	Don Alden	Determination of the real electrochemical surface areas of screen printed electrodes
US8103456B2 (en)	2009-01-29	2012-01-24	Abbott Diabetes Care Inc.	Method and device for early signal attenuation detection using blood glucose measurements
US9375169B2 (en) *	2009-01-30	2016-06-28	Sanofi-Aventis Deutschland Gmbh	Cam drive for managing disposable penetrating member actions with a single motor and motor and control system
US9402544B2 (en)	2009-02-03	2016-08-02	Abbott Diabetes Care Inc.	Analyte sensor and apparatus for insertion of the sensor
US20100213057A1 (en) *	2009-02-26	2010-08-26	Benjamin Feldman	Self-Powered Analyte Sensor
US9226701B2 (en) *	2009-04-28	2016-01-05	Abbott Diabetes Care Inc.	Error detection in critical repeating data in a wireless sensor system
US9184490B2 (en)	2009-05-29	2015-11-10	Abbott Diabetes Care Inc.	Medical device antenna systems having external antenna configurations
WO2011025999A1 (en) *	2009-08-29	2011-03-03	Abbott Diabetes Care Inc.	Analyte sensor
WO2011026130A1 (en) *	2009-08-31	2011-03-03	Abbott Diabetes Care Inc.	Inserter device including rotor subassembly
EP2473099A4 (en)	2009-08-31	2015-01-14	Abbott Diabetes Care Inc	ANALYTICAL SUBSTANCE MONITORING SYSTEM AND METHODS OF MANAGING ENERGY AND NOISE
WO2011026147A1 (en)	2009-08-31	2011-03-03	Abbott Diabetes Care Inc.	Analyte signal processing device and methods
WO2011041469A1 (en)	2009-09-29	2011-04-07	Abbott Diabetes Care Inc.	Method and apparatus for providing notification function in analyte monitoring systems
WO2011044386A1 (en) *	2009-10-07	2011-04-14	Abbott Diabetes Care Inc.	Sensor inserter assembly having rotatable trigger
USD924406S1 (en)	2010-02-01	2021-07-06	Abbott Diabetes Care Inc.	Analyte sensor inserter
CA3134869C (en)	2010-03-24	2024-03-05	Abbott Diabetes Care Inc.	Medical device inserters and processes of inserting and using medical devices
US8965476B2 (en)	2010-04-16	2015-02-24	Sanofi-Aventis Deutschland Gmbh	Tissue penetration device
US11064921B2 (en)	2010-06-29	2021-07-20	Abbott Diabetes Care Inc.	Devices, systems and methods for on-skin or on-body mounting of medical devices
CA2838797C (en)	2011-07-27	2020-03-10	Agamatrix, Inc.	Dry reagent comprising tetramethylammonium ferricyanide for electrochemical test strips
EP3677182B1 (en)	2011-11-07	2022-05-04	Abbott Diabetes Care Inc.	Analyte monitoring device and methods
EP4344633A3 (en)	2011-12-11	2024-10-02	Abbott Diabetes Care, Inc.	Analyte sensor methods
US9968306B2 (en)	2012-09-17	2018-05-15	Abbott Diabetes Care Inc.	Methods and apparatuses for providing adverse condition notification with enhanced wireless communication range in analyte monitoring systems
US20140251836A1 (en) *	2013-03-08	2014-09-11	Magellan Diagnostics, Inc.	Apparatus and method for analyzing multiple samples
US10213139B2 (en)	2015-05-14	2019-02-26	Abbott Diabetes Care Inc.	Systems, devices, and methods for assembling an applicator and sensor control device
AU2016260547B2 (en)	2015-05-14	2020-09-03	Abbott Diabetes Care Inc.	Compact medical device inserters and related systems and methods
US20170108458A1 (en) *	2015-10-15	2017-04-20	Arkray, Inc.	Biosensor
US11071478B2 (en)	2017-01-23	2021-07-27	Abbott Diabetes Care Inc.	Systems, devices and methods for analyte sensor insertion
CN115942909A (zh)	2020-08-31	2023-04-07	雅培糖尿病护理公司	用于分析物传感器插入的系统、装置和方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3278334D1 (en) *	1981-10-23	1988-05-19	Genetics Int Inc	Sensor for components of a liquid mixture
JPS58153154A (ja) *	1982-03-09	1983-09-12	Ajinomoto Co Inc	修飾電極
DE3221339A1 (de) *	1982-06-05	1983-12-08	Basf Ag, 6700 Ludwigshafen	Verfahren zur elektrochemischen hydrierung von nicotinamidadenin-dinucleotid
DE3571456D1 (en) *	1984-04-30	1989-08-17	Stiftung R E	Process for the sensitization of an oxidoreduction photocalatyst, and photocatalyst thus obtained
GB8612861D0 (en) *	1986-05-27	1986-07-02	Cambridge Life Sciences	Immobilised enzyme biosensors
US4974929A (en) *	1987-09-22	1990-12-04	Baxter International, Inc.	Fiber optical probe connector for physiologic measurement devices
US5205920A (en) *	1989-03-03	1993-04-27	Noboru Oyama	Enzyme sensor and method of manufacturing the same
US5198367A (en) *	1989-06-09	1993-03-30	Masuo Aizawa	Homogeneous amperometric immunoassay

1991
- 1991-02-21 FR FR919102200A patent/FR2673289B1/fr not_active Expired - Fee Related
1992
- 1992-02-19 EP EP92903775A patent/EP0526602B1/fr not_active Expired - Lifetime
- 1992-02-19 AU AU12219/92A patent/AU656360B2/en not_active Expired
- 1992-02-19 US US07/938,219 patent/US5378628A/en not_active Expired - Lifetime
- 1992-02-19 WO PCT/CH1992/000034 patent/WO1992014836A1/fr active IP Right Grant
- 1992-02-19 AT AT92903775T patent/ATE147107T1/de not_active IP Right Cessation
- 1992-02-19 JP JP4503902A patent/JP2770250B2/ja not_active Expired - Lifetime
- 1992-02-19 CA CA002080840A patent/CA2080840C/en not_active Expired - Lifetime
- 1992-02-19 PL PL92296491A patent/PL169972B1/pl unknown
- 1992-02-19 SK SK3165-92A patent/SK316592A3/sk unknown
- 1992-02-19 DE DE69216319T patent/DE69216319T2/de not_active Expired - Lifetime
- 1992-02-19 HU HU9203285A patent/HU212451B/hu not_active IP Right Cessation
- 1992-10-19 FI FI924726A patent/FI924726A0/fi unknown
- 1992-10-19 BG BG96988A patent/BG96988A/xx unknown

Also Published As

Publication number	Publication date
CA2080840A1 (en)	1992-08-22
US5378628A (en)	1995-01-03
BG96988A (en)	1994-03-31
CA2080840C (en)	1999-04-06
ATE147107T1 (de)	1997-01-15
FR2673289B1 (fr)	1994-06-17
EP0526602B1 (fr)	1997-01-02
AU1221992A (en)	1992-09-15
FI924726L (fi)	1992-10-19
PL169972B1 (pl)	1996-09-30
JPH05506102A (ja)	1993-09-02
FI924726A0 (fi)	1992-10-19
FR2673289A1 (fr)	1992-08-28
DE69216319D1 (de)	1997-02-13
EP0526602A1 (fr)	1993-02-10
HU212451B (en)	1996-06-28
AU656360B2 (en)	1995-02-02
HUT66200A (en)	1994-10-28
DE69216319T2 (de)	1997-07-03
WO1992014836A1 (fr)	1992-09-03
JP2770250B2 (ja)	1998-06-25

Publication	Publication Date	Title
SK316592A3 (en)	1995-04-12	Sensor for measuring the quantity of a dissolved component
US10457971B2 (en)	2019-10-29	Method of making an electrochemical sensor strip
CN104280431B (zh)	2017-06-30	用于生物传感器的试剂组合物及包含所述试剂组合物的生物传感器
US9206460B2 (en)	2015-12-08	Concentration determination in a diffusion barrier layer
Kuhn	1998	Biosensors: blockbuster or bomb? Electrochemical biosensors for diabetes monitoring
White et al.	2024	Mediated amperometric biosensors
Sakdaphetsiri et al.	2020	Rapid sub-micromolar amperometric enzyme biosensing with free substrate access but without nanomaterial signalling support: Oxidase-based glucose detection as a proof-of-principle example
EP3777683A1 (en)	2021-02-17	Sensor using phenazine derivative or high molecular weight redox polymer containing phenazine derivative
US20230218211A1 (en)	2023-07-13	Method for determining an actual concentration of a substrate using an array of self-calibrated biosensors and device for implementing the method
FR2677766A1 (fr)	1992-12-18	Capteur de mesure de la quantite d'un composant en solution.
CZ316592A3 (en)	1993-04-14	sensor for measuring a component amount in a solution
AU2014274588B2 (en)	2016-01-14	Concentration determination in a diffusion barrier layer
Weckström	2023	Enzyme-mediator coupling for non-invasive glucose monitoring
AU2012203435B2 (en)	2014-09-11	Concentration determination in a diffusion barrier layer
Higgins et al.	1987	Harnessing biologically-catalysed electron transfer reactions for biosensors
AU2016202064A1 (en)	2016-04-28	Concentration determination in a diffusion barrier layer
Bhusal	2013	Preparation of amperometric glucose biosensor by means of electropolymerisation of polyaniline onto graphite