SK286156B6 - Azolový derivát, spôsob prípravy tohto azolového derivátu, použitie tohto azolového derivátu na výrobu liečiva a farmaceutická kompozícia obsahujúca tento azolový derivát - Google Patents

Azolový derivát, spôsob prípravy tohto azolového derivátu, použitie tohto azolového derivátu na výrobu liečiva a farmaceutická kompozícia obsahujúca tento azolový derivát Download PDF

Info

Publication number: SK286156B6
Authority: SK; Slovakia
Prior art keywords: formula; alkyl; group; radical; carbon atoms
Prior art date: 1998-05-14

Application number

SK1681-2000A

Other languages

English (en)

Slovak (sk)

Other versions

SK16812000A3 (sk

Inventor

Lieven Meerpoel

Leo Jacobus Jozef Backx

Der Veken Louis Jozef Elisabeth Van

Original Assignee

Janssen Pharmaceutica N. V.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-05-14

Filing date

1999-05-06

Publication date

2008-04-07

1999-05-06 Application filed by Janssen Pharmaceutica N. V. filed Critical Janssen Pharmaceutica N. V.

2001-08-06 Publication of SK16812000A3 publication Critical patent/SK16812000A3/sk

2008-04-07 Publication of SK286156B6 publication Critical patent/SK286156B6/sk

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D249/12—Oxygen or sulfur atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Communicable Diseases (AREA)
Pharmacology & Pharmacy (AREA)
Oncology (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)

SK1681-2000A 1998-05-14 1999-05-06 Azolový derivát, spôsob prípravy tohto azolového derivátu, použitie tohto azolového derivátu na výrobu liečiva a farmaceutická kompozícia obsahujúca tento azolový derivát SK286156B6 (sk)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP98201588A EP0957101A1 (en)	1998-05-14	1998-05-14	Water soluble azoles as broad-spectrum antifungals
PCT/EP1999/003242 WO1999058529A1 (en)	1998-05-14	1999-05-06	Water soluble azoles as broad-spectrum antifungals

Publications (2)

Publication Number	Publication Date
SK16812000A3 SK16812000A3 (sk)	2001-08-06
SK286156B6 true SK286156B6 (sk)	2008-04-07

Family

ID=8233724

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
SK1681-2000A SK286156B6 (sk)	1998-05-14	1999-05-06	Azolový derivát, spôsob prípravy tohto azolového derivátu, použitie tohto azolového derivátu na výrobu liečiva a farmaceutická kompozícia obsahujúca tento azolový derivát
SK1682-2000A SK285763B6 (sk)	1998-05-14	1999-05-06	Azol, spôsob jeho prípravy a medziprodukt na jehoprípravu, jeho použitie a farmaceutický prostriedok s jeho obsahom

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
SK1682-2000A SK285763B6 (sk)	1998-05-14	1999-05-06	Azol, spôsob jeho prípravy a medziprodukt na jehoprípravu, jeho použitie a farmaceutický prostriedok s jeho obsahom

Country Status (32)

Country	Link
US (2)	US6448244B1 (pt)
EP (3)	EP0957101A1 (pt)
JP (2)	JP2002514646A (pt)
KR (2)	KR100575147B1 (pt)
CN (2)	CN1137118C (pt)
AR (2)	AR016480A1 (pt)
AT (2)	ATE238296T1 (pt)
AU (2)	AU758876B2 (pt)
BG (2)	BG64388B1 (pt)
BR (2)	BR9911057A (pt)
CA (2)	CA2331187C (pt)
CO (1)	CO5021227A1 (pt)
CZ (2)	CZ298702B6 (pt)
DE (2)	DE69907171T2 (pt)
DK (1)	DK1077976T3 (pt)
EE (2)	EE04346B1 (pt)
ES (2)	ES2182531T3 (pt)
HK (2)	HK1032781A1 (pt)
HR (2)	HRP20000741B1 (pt)
HU (2)	HUP0102031A3 (pt)
IL (2)	IL139647A0 (pt)
MY (2)	MY122147A (pt)
NO (2)	NO319760B1 (pt)
NZ (2)	NZ507965A (pt)
PL (2)	PL194086B1 (pt)
PT (1)	PT1077976E (pt)
SI (1)	SI1077976T1 (pt)
SK (2)	SK286156B6 (pt)
TR (2)	TR200003323T2 (pt)
TW (2)	TWI259835B (pt)
WO (2)	WO1999058530A1 (pt)
ZA (2)	ZA200007173B (pt)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0957101A1 (en) *	1998-05-14	1999-11-17	Janssen Pharmaceutica N.V.	Water soluble azoles as broad-spectrum antifungals
CA2402345A1 (en) *	2000-03-07	2001-09-13	Sudershan K. Arora	Azole compounds as therapeutic agents for fungal infections
EP1413301A1 (fr) *	2002-10-24	2004-04-28	Bayer CropScience SA	Médicaments antifongiques à base de dérivés d'arylamidine
ITMI20032020A1 (it) *	2003-10-17	2005-04-18	Italfarmaco Spa	Nuovi agenti antifungini azolici con diminuita interazione con i citocromi metabolici
AR052342A1 (es) *	2004-12-21	2007-03-14	Janssen Pharmaceutica Nv	Derivados sustituidos de triazolona,tetrazolona e imidazolona con actividad selectiva antagonista de alfa2c-adenoreceptores
WO2011144653A1 (en) *	2010-05-19	2011-11-24	Sandoz Ag	Process for the preparation of chiral triazolones
US11028078B2 (en) *	2011-09-07	2021-06-08	The Johns Hopkins University	Itraconazole analogs and use thereof
WO2013036866A1 (en) *	2011-09-07	2013-03-14	The Johns Hopkins University	Itraconazole analogs and use thereof
PT3003038T (pt)	2013-06-07	2019-11-19	Scripps Research Inst	Derivados 2h-1,2,3-triazólicos como inibidores de fibrose
CA2963625C (en)	2014-12-05	2023-08-22	Pulmocide Limited	4-(4-(4-(((3r,5r)-5-((1h-1,2,4-triazol-1-yl)methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)methoxy)-3-methylphenyl)piperazin-1-yl)-n-(4-fluorophenyl)benzamide or salts thereof, and use to treat mycoses
JP6706023B2 (ja)	2014-12-10	2020-06-03	ザ・スクリップス・リサーチ・インスティテュート	線維症の小分子阻害剤
EA032454B1 (ru) *	2015-05-21	2019-05-31	Палмосайд Лимитед	Противогрибковый 4-(4-(4-(((3r,5r)-5-((1h-1,2,4-триазол-1-ил)метил)-5-(2,4-дифторфенил)тетрагидрофуран-3-ил)метокси)-3-метилфенил)пиперазин-1-ил)-n-(2-гидроксициклогексил)бензамид или его фармацевтически приемлемая соль
CN105237392B (zh) *	2015-11-24	2017-12-12	辽宁渤大化工有限公司	芳烷基水杨酸及其衍生物的制备方法
WO2019040363A1 (en) *	2017-08-20	2019-02-28	University Of Connecticut	AZOLE-TYPE COMPOUND ANALOGUES AND METHODS OF USE
CN111138421A (zh) *	2019-12-26	2020-05-12	上海英诺富成生物科技有限公司	抗真菌水溶性化合物及其制备方法与应用

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4218458A (en) *	1978-06-23	1980-08-19	Janssen Pharmaceutica, N.V.	Heterocyclic derivatives of (4-aryloxy-methyl-1,3-dioxolan-2-yl)methyl-1H-imidazoles and 1H-1,2,4-triazoles
ES2158859T3 (es) *	1992-03-18	2001-09-16	Janssen Pharmaceutica Nv	Estereoisomeros itraconazol y saperconazol.
CA2179396C (en) *	1993-12-21	2001-04-17	Anil K. Saksena	Tetrahydrofuran antifungals
PT741737E (pt) *	1994-01-24	2000-04-28	Janssen Pharmaceutica Nv	Antifungicos do tipo azole soluveis em agua
FI98688C (fi) *	1994-07-20	1997-07-25	Nokia Telecommunications Oy	Menetelmä lyhytsanomalähetyksen käynnistämiseksi solukkoradiojärjestelmässä, solukkoradiojärjestelmä sekä solukkoradiojärjestelmän tilaajarekisteri
DE69628117T2 (de) *	1995-06-02	2004-04-01	Schering Corp.	Antifungale tetrahydrofurane
JPH11507668A (ja) *	1995-06-19	1999-07-06	シェーリングコーポレイション	テトラヒドロフラン抗真菌剤
ES2224364T3 (es) *	1997-02-11	2005-03-01	Janssen Pharmaceutica N.V.	Azoles antifungicos que contienen esteres de aminoacidos.
EP0957101A1 (en) *	1998-05-14	1999-11-17	Janssen Pharmaceutica N.V.	Water soluble azoles as broad-spectrum antifungals

1998
- 1998-05-14 EP EP98201588A patent/EP0957101A1/en not_active Withdrawn
1999
- 1999-05-06 DE DE69907171T patent/DE69907171T2/de not_active Expired - Lifetime
- 1999-05-06 PL PL99344037A patent/PL194086B1/pl unknown
- 1999-05-06 CA CA002331187A patent/CA2331187C/en not_active Expired - Fee Related
- 1999-05-06 EP EP99926304A patent/EP1077976B1/en not_active Expired - Lifetime
- 1999-05-06 AT AT99924942T patent/ATE238296T1/de not_active IP Right Cessation
- 1999-05-06 AU AU43615/99A patent/AU758876B2/en not_active Ceased
- 1999-05-06 CN CNB998059560A patent/CN1137118C/zh not_active Expired - Fee Related
- 1999-05-06 CZ CZ20004109A patent/CZ298702B6/cs not_active IP Right Cessation
- 1999-05-06 CN CNB998060690A patent/CN1135229C/zh not_active Expired - Fee Related
- 1999-05-06 EE EEP200000651A patent/EE04346B1/xx not_active IP Right Cessation
- 1999-05-06 SI SI9930131T patent/SI1077976T1/xx unknown
- 1999-05-06 EE EEP200000657A patent/EE04311B1/xx not_active IP Right Cessation
- 1999-05-06 TR TR2000/03323T patent/TR200003323T2/xx unknown
- 1999-05-06 SK SK1681-2000A patent/SK286156B6/sk not_active IP Right Cessation
- 1999-05-06 PL PL99344047A patent/PL194085B1/pl unknown
- 1999-05-06 JP JP2000548334A patent/JP2002514646A/ja active Pending
- 1999-05-06 CA CA002331141A patent/CA2331141C/en not_active Expired - Fee Related
- 1999-05-06 AU AU41417/99A patent/AU751135B2/en not_active Ceased
- 1999-05-06 WO PCT/EP1999/003243 patent/WO1999058530A1/en active IP Right Grant
- 1999-05-06 KR KR1020007011624A patent/KR100575147B1/ko not_active IP Right Cessation
- 1999-05-06 NZ NZ507965A patent/NZ507965A/en not_active IP Right Cessation
- 1999-05-06 BR BR9911057-1A patent/BR9911057A/pt not_active Application Discontinuation
- 1999-05-06 CZ CZ20004108A patent/CZ299481B6/cs not_active IP Right Cessation
- 1999-05-06 BR BR9910448-2A patent/BR9910448A/pt not_active Application Discontinuation
- 1999-05-06 HU HU0102031A patent/HUP0102031A3/hu unknown
- 1999-05-06 IL IL13964799A patent/IL139647A0/xx not_active IP Right Cessation
- 1999-05-06 US US09/700,166 patent/US6448244B1/en not_active Expired - Lifetime
- 1999-05-06 KR KR1020007009640A patent/KR100593395B1/ko active IP Right Grant
- 1999-05-06 US US09/700,251 patent/US6384030B1/en not_active Expired - Lifetime
- 1999-05-06 NZ NZ507966A patent/NZ507966A/xx not_active IP Right Cessation
- 1999-05-06 PT PT99926304T patent/PT1077976E/pt unknown
- 1999-05-06 ES ES99926304T patent/ES2182531T3/es not_active Expired - Lifetime
- 1999-05-06 TR TR2000/03322T patent/TR200003322T2/xx unknown
- 1999-05-06 HU HU0103536A patent/HUP0103536A3/hu unknown
- 1999-05-06 EP EP99924942A patent/EP1077975B1/en not_active Expired - Lifetime
- 1999-05-06 ES ES99924942T patent/ES2198915T3/es not_active Expired - Lifetime
- 1999-05-06 JP JP2000548333A patent/JP2002514645A/ja active Pending
- 1999-05-06 DK DK99926304T patent/DK1077976T3/da active
- 1999-05-06 AT AT99926304T patent/ATE221884T1/de active
- 1999-05-06 DE DE69902461T patent/DE69902461T2/de not_active Expired - Lifetime
- 1999-05-06 IL IL13964999A patent/IL139649A/en not_active IP Right Cessation
- 1999-05-06 SK SK1682-2000A patent/SK285763B6/sk not_active IP Right Cessation
- 1999-05-06 WO PCT/EP1999/003242 patent/WO1999058529A1/en active IP Right Grant
- 1999-05-10 TW TW088107505A patent/TWI259835B/zh not_active IP Right Cessation
- 1999-05-10 TW TW088107504A patent/TW572899B/zh not_active IP Right Cessation
- 1999-05-11 MY MYPI99001862A patent/MY122147A/en unknown
- 1999-05-11 MY MYPI99001861A patent/MY120248A/en unknown
- 1999-05-13 CO CO99029778A patent/CO5021227A1/es unknown
- 1999-05-13 AR ARP990102270A patent/AR016480A1/es active IP Right Grant
- 1999-05-13 AR ARP990102276A patent/AR016482A1/es active IP Right Grant
2000
- 2000-08-28 BG BG104717A patent/BG64388B1/bg unknown
- 2000-11-02 HR HR20000741A patent/HRP20000741B1/xx not_active IP Right Cessation
- 2000-11-02 HR HR20000740A patent/HRP20000740B1/xx not_active IP Right Cessation
- 2000-11-09 BG BG104933A patent/BG64954B1/bg unknown
- 2000-11-13 NO NO20005713A patent/NO319760B1/no not_active IP Right Cessation
- 2000-11-13 NO NO20005712A patent/NO319851B1/no not_active IP Right Cessation
- 2000-12-04 ZA ZA200007173A patent/ZA200007173B/en unknown
- 2000-12-13 ZA ZA200007459A patent/ZA200007459B/xx unknown
2001
- 2001-05-19 HK HK01103466A patent/HK1032781A1/xx not_active IP Right Cessation
- 2001-05-19 HK HK01103465A patent/HK1033312A1/xx not_active IP Right Cessation

Also Published As

Publication number	Publication date
CN1135229C (zh)	2004-01-21
TW572899B (en)	2004-01-21
AU4361599A (en)	1999-11-29
HUP0102031A2 (hu)	2002-05-29
IL139649A (en)	2004-09-27
TWI259835B (en)	2006-08-11
BR9910448A (pt)	2001-01-02
BG104933A (en)	2001-10-31
DK1077976T3 (da)	2002-12-02
HUP0103536A3 (en)	2002-08-28
SK16822000A3 (sk)	2001-07-10
WO1999058530A1 (en)	1999-11-18
PL194085B1 (pl)	2007-04-30
NO20005713L (no)	2001-01-11
NZ507965A (en)	2002-05-31
CZ299481B6 (cs)	2008-08-13
DE69902461T2 (de)	2003-04-10
SK285763B6 (sk)	2007-07-06
ES2198915T3 (es)	2004-02-01
TR200003322T2 (tr)	2001-02-21
EP1077975A1 (en)	2001-02-28
EE04311B1 (et)	2004-06-15
US6448244B1 (en)	2002-09-10
AR016482A1 (es)	2001-07-04
CA2331141A1 (en)	1999-11-18
CZ20004109A3 (en)	2001-05-16
NO319760B1 (no)	2005-09-12
PL344047A1 (en)	2001-09-24
CN1137118C (zh)	2004-02-04
HRP20000741A2 (en)	2001-06-30
CA2331187A1 (en)	1999-11-18
HUP0102031A3 (en)	2002-10-28
TR200003323T2 (tr)	2001-02-21
AU758876B2 (en)	2003-04-03
KR20010042852A (ko)	2001-05-25
KR100575147B1 (ko)	2006-05-03
EP1077975B1 (en)	2003-04-23
CZ298702B6 (cs)	2007-12-27
WO1999058529A1 (en)	1999-11-18
BR9911057A (pt)	2001-02-06
JP2002514646A (ja)	2002-05-21
EP1077976A1 (en)	2001-02-28
JP2002514645A (ja)	2002-05-21
ATE238296T1 (de)	2003-05-15
SK16812000A3 (sk)	2001-08-06
DE69907171D1 (de)	2003-05-28
CA2331141C (en)	2008-10-28
NO319851B1 (no)	2005-09-19
EE04346B1 (et)	2004-08-16
DE69902461D1 (de)	2002-09-12
MY122147A (en)	2006-03-31
PT1077976E (pt)	2002-12-31
CN1300288A (zh)	2001-06-20
PL194086B1 (pl)	2007-04-30
BG64954B1 (bg)	2006-10-31
KR20010041480A (ko)	2001-05-25
ATE221884T1 (de)	2002-08-15
AR016480A1 (es)	2001-07-04
IL139647A0 (en)	2002-02-10
EE200000657A (et)	2002-04-15
SI1077976T1 (en)	2003-02-28
ZA200007459B (en)	2002-09-13
NZ507966A (en)	2002-10-25
NO20005712L (no)	2000-12-07
DE69907171T2 (de)	2004-02-05
IL139649A0 (en)	2002-02-10
CO5021227A1 (es)	2001-03-27
CN1300287A (zh)	2001-06-20
NO20005712D0 (no)	2000-11-13
HRP20000741B1 (en)	2009-02-28
EP0957101A1 (en)	1999-11-17
EE200000651A (et)	2002-04-15
CA2331187C (en)	2008-11-18
BG104717A (en)	2001-07-31
HRP20000740A2 (en)	2001-10-31
MY120248A (en)	2005-09-30
BG64388B1 (bg)	2004-12-30
NO20005713D0 (no)	2000-11-13
AU751135B2 (en)	2002-08-08
HRP20000740B1 (en)	2003-12-31
HK1032781A1 (en)	2001-08-03
CZ20004108A3 (en)	2001-05-16
EP1077976B1 (en)	2002-08-07
ZA200007173B (en)	2002-03-04
HUP0103536A2 (hu)	2002-07-29
AU4141799A (en)	1999-11-29
ES2182531T3 (es)	2003-03-01
HK1033312A1 (en)	2001-08-24
KR100593395B1 (ko)	2006-06-28
US6384030B1 (en)	2002-05-07
PL344037A1 (en)	2001-09-24

Publication	Publication Date	Title
CZ297769B6 (cs)	2007-03-28	N-[4-(heteroarylmetyl)fenyl]-heteroarylaminy, zpusob jejich prípravy a jejich pouzití jako léciva
SK286156B6 (sk)	2008-04-07	Azolový derivát, spôsob prípravy tohto azolového derivátu, použitie tohto azolového derivátu na výrobu liečiva a farmaceutická kompozícia obsahujúca tento azolový derivát
EP1177192B1 (en)	2003-03-19	Antifungal ethers
MXPA00011155A (es)	2001-07-31	Azoles solubles en agua como antifungicos de amplio espectro
MXPA00011152A (en)	2001-07-31	Water soluble azoles as broad-spectrum antifungals

Legal Events

Date	Code	Title	Description
2010-02-08	MM4A	Patent lapsed due to non-payment of maintenance fees	Effective date: 20090506