SK283003B6 - 1-beta-D-Arabinofuranozylcytozínový derivát, jeho použitie a farmaceutický prípravok s jeho obsahom - Google Patents

1-beta-D-Arabinofuranozylcytozínový derivát, jeho použitie a farmaceutický prípravok s jeho obsahom Download PDF

Info

Publication number: SK283003B6
Authority: SK; Slovakia
Prior art keywords: ara; elaidate; hydrogen; treatment; cells
Prior art date: 1995-07-25

Application number

SK80-98A

Other languages

English (en)

Slovak (sk)

Other versions

SK8098A3 (en

Inventor

Finn Myhren

Bernt Borretzen

Are Dalen

Kjell Torgeir Stokke

Original Assignee

Conpharma As

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-07-25

Filing date

1996-07-12

Publication date

2003-01-09

1996-07-12 Application filed by Conpharma As filed Critical Conpharma As

1998-07-08 Publication of SK8098A3 publication Critical patent/SK8098A3/sk

2003-01-09 Publication of SK283003B6 publication Critical patent/SK283003B6/sk

Links

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UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims abstract description 17
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208000020470 nervous system symptom Diseases 0.000 description 1
QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
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229940104230 thymidine Drugs 0.000 description 1
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235000010384 tocopherol Nutrition 0.000 description 1
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239000011732 tocopherol Substances 0.000 description 1
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230000002588 toxic effect Effects 0.000 description 1
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239000001226 triphosphate Substances 0.000 description 1
235000011178 triphosphate Nutrition 0.000 description 1
UNXRWKVEANCORM-UHFFFAOYSA-N triphosphoric acid Chemical compound OP(O)(=O)OP(O)(=O)OP(O)(O)=O UNXRWKVEANCORM-UHFFFAOYSA-N 0.000 description 1
235000021122 unsaturated fatty acids Nutrition 0.000 description 1
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Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/052—Imidazole radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/056—Triazole or tetrazole radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biotechnology (AREA)
Biochemistry (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Medicinal Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Hematology (AREA)
Oncology (AREA)
Bioinformatics & Cheminformatics (AREA)
Diabetes (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Polyamides (AREA)
Artificial Filaments (AREA)

SK80-98A 1995-07-25 1996-07-12 1-beta-D-Arabinofuranozylcytozínový derivát, jeho použitie a farmaceutický prípravok s jeho obsahom SK283003B6 (sk)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GBGB9515279.9A GB9515279D0 (en)	1995-07-25	1995-07-25	Improved therapeutic agents
PCT/NO1996/000179 WO1997005154A1 (en)	1995-07-25	1996-07-12	Improved therapeutic agents

Publications (2)

Publication Number	Publication Date
SK8098A3 SK8098A3 (en)	1998-07-08
SK283003B6 true SK283003B6 (sk)	2003-01-09

Family

ID=10778247

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SK80-98A SK283003B6 (sk)	1995-07-25	1996-07-12	1-beta-D-Arabinofuranozylcytozínový derivát, jeho použitie a farmaceutický prípravok s jeho obsahom

Country Status (25)

Country	Link
US (2)	US6316425B1 (da)
EP (1)	EP0842185B1 (da)
JP (2)	JP4372227B2 (da)
KR (1)	KR100401909B1 (da)
AT (1)	ATE207076T1 (da)
AU (1)	AU714814B2 (da)
CA (1)	CA2227533C (da)
CZ (1)	CZ291612B6 (da)
DE (1)	DE69616074T2 (da)
DK (1)	DK0842185T3 (da)
ES (1)	ES2166900T3 (da)
GB (1)	GB9515279D0 (da)
HU (1)	HU224839B1 (da)
IL (2)	IL122942A0 (da)
MX (1)	MX9800622A (da)
NO (1)	NO313985B1 (da)
NZ (1)	NZ313790A (da)
PL (1)	PL183601B1 (da)
PT (1)	PT842185E (da)
RU (1)	RU2165260C2 (da)
SK (1)	SK283003B6 (da)
TW (1)	TW434251B (da)
UA (1)	UA55389C2 (da)
WO (1)	WO1997005154A1 (da)
ZA (1)	ZA966047B (da)

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US6458772B1 (en)	1909-10-07	2002-10-01	Medivir Ab	Prodrugs
KR20000053226A (ko) *	1996-11-12	2000-08-25	요나스 프릭	뉴클레오사이드
DK0986570T3 (da) *	1997-01-24	2003-07-28	Conpharma As	Gemcitabinderivat
RU2207573C2 (ru) *	2001-08-27	2003-06-27	Новичков Евгений Владимирович	Способ прогнозирования продолжительности жизни больных печеночно-клеточной карциномой
US7393862B2 (en) *	2002-05-17	2008-07-01	Celgene Corporation	Method using 3-(4-amino-1-oxo-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione for treatment of certain leukemias
KR20060092242A (ko) *	2003-11-03	2006-08-22	코그니스 아이피 매니지먼트 게엠베하	아실 리보뉴클레오시드 및 아실 데옥시리보뉴클레오시드
NO324263B1 (no) *	2005-12-08	2007-09-17	Clavis Pharma Asa	Kjemiske forbindelser, anvendelse derav ved behandling av kreft, samt farmasoytiske preparater som omfatter slike forbindelser
US8497292B2 (en)	2005-12-28	2013-07-30	Translational Therapeutics, Inc.	Translational dysfunction based therapeutics
CA2700207A1 (en) *	2007-09-26	2009-04-02	Mount Sinai School Of Medicine	Azacytidine analogues and uses thereof
GB0808357D0 (en) *	2008-05-08	2008-06-18	Cyclacel Ltd	Process
CA2778432A1 (en) *	2009-11-20	2011-05-26	Clavis Pharma Asa	Parenteral formulations of gemcitabine derivatives
JP5903097B2 (ja) *	2010-07-13	2016-04-13	クラビスファーマエイエスエイ	エラシタラビン誘導体の非経口製剤
RU2600734C2 (ru) *	2012-03-28	2016-10-27	Фуджифилм Корпорэйшн	СОЛЬ 1-(2-ДЕЗОКСИ-2-ФТОР-4-ТИО-β-D-АРАБИНОФУРАНОЗИЛ)ЦИТОЗИНА
EP3740287A4 (en)	2018-01-15	2021-11-03	Yinuoke Medicine Science And Technology Company Ltd.	TREATMENTS FOR CACHEXIA

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Publication number	Priority date	Publication date	Assignee	Title
US3894000A (en) *	1971-01-27	1975-07-08	Upjohn Co	Ara-cytidine derivatives and process of preparation
US4771056A (en) *	1985-08-29	1988-09-13	Roman Rozencwaig	Method of medical treatment with serotonin antagonists
CA2079413C (en)	1991-09-30	2003-09-09	Masakatsu Kaneko	Pyrimidine nucleoside derivatives having anti-tumor activity, their preparation and use
GB2266525A (en) *	1992-03-17	1993-11-03	Merck & Co Inc	Substituted cephalosporin sulfone compositions useful in the treatment of leukemia
GB9307043D0 (en) *	1993-04-05	1993-05-26	Norsk Hydro As	Chemical compounds
US5641758A (en)	1993-11-10	1997-06-24	Kluge; Michael	Cytarabine derivatives, the preparation and use thereof

1995
- 1995-07-25 GB GBGB9515279.9A patent/GB9515279D0/en active Pending
1996
- 1996-07-12 HU HU9900924A patent/HU224839B1/hu not_active IP Right Cessation
- 1996-07-12 NZ NZ313790A patent/NZ313790A/xx not_active IP Right Cessation
- 1996-07-12 US US08/983,483 patent/US6316425B1/en not_active Expired - Lifetime
- 1996-07-12 AU AU66335/96A patent/AU714814B2/en not_active Ceased
- 1996-07-12 AT AT96926032T patent/ATE207076T1/de active
- 1996-07-12 SK SK80-98A patent/SK283003B6/sk not_active IP Right Cessation
- 1996-07-12 ES ES96926032T patent/ES2166900T3/es not_active Expired - Lifetime
- 1996-07-12 EP EP96926032A patent/EP0842185B1/en not_active Expired - Lifetime
- 1996-07-12 CZ CZ1998163A patent/CZ291612B6/cs not_active IP Right Cessation
- 1996-07-12 IL IL12294296A patent/IL122942A0/xx active IP Right Grant
- 1996-07-12 RU RU98103238/04A patent/RU2165260C2/ru not_active IP Right Cessation
- 1996-07-12 DK DK96926032T patent/DK0842185T3/da active
- 1996-07-12 DE DE69616074T patent/DE69616074T2/de not_active Expired - Lifetime
- 1996-07-12 JP JP50750497A patent/JP4372227B2/ja not_active Expired - Fee Related
- 1996-07-12 KR KR10-1998-0700463A patent/KR100401909B1/ko not_active Expired - Fee Related
- 1996-07-12 PL PL96324690A patent/PL183601B1/pl not_active IP Right Cessation
- 1996-07-12 PT PT96926032T patent/PT842185E/pt unknown
- 1996-07-12 WO PCT/NO1996/000179 patent/WO1997005154A1/en active IP Right Grant
- 1996-07-12 CA CA002227533A patent/CA2227533C/en not_active Expired - Fee Related
- 1996-07-16 ZA ZA9606047A patent/ZA966047B/xx unknown
- 1996-10-02 TW TW085111996A patent/TW434251B/zh not_active IP Right Cessation
- 1996-12-07 UA UA98020922A patent/UA55389C2/uk unknown
1998
- 1998-01-15 IL IL122942A patent/IL122942A/en not_active IP Right Cessation
- 1998-01-21 MX MX9800622A patent/MX9800622A/es not_active IP Right Cessation
- 1998-01-23 NO NO19980296A patent/NO313985B1/no not_active IP Right Cessation
1999
- 1999-11-09 US US09/435,641 patent/US6335322B1/en not_active Expired - Fee Related
2009
- 2009-07-03 JP JP2009159081A patent/JP5087052B2/ja not_active Expired - Lifetime

Also Published As

Publication number	Publication date
JP4372227B2 (ja)	2009-11-25
CZ16398A3 (cs)	1998-06-17
JP2009215326A (ja)	2009-09-24
HUP9900924A2 (hu)	2001-05-28
CZ291612B6 (cs)	2003-04-16
DE69616074D1 (de)	2001-11-22
HUP9900924A3 (en)	2001-06-28
UA55389C2 (uk)	2003-04-15
DK0842185T3 (da)	2002-02-04
RU2165260C2 (ru)	2001-04-20
IL122942A0 (en)	1999-05-09
ZA966047B (en)	1997-02-04
NO980296D0 (no)	1998-01-23
PL324690A1 (en)	1998-06-08
NZ313790A (en)	1999-07-29
JP5087052B2 (ja)	2012-11-28
CA2227533A1 (en)	1997-02-13
EP0842185B1 (en)	2001-10-17
PT842185E (pt)	2002-04-29
ATE207076T1 (de)	2001-11-15
WO1997005154A1 (en)	1997-02-13
DE69616074T2 (de)	2002-06-06
JP2002504068A (ja)	2002-02-05
US6335322B1 (en)	2002-01-01
KR100401909B1 (ko)	2004-02-14
TW434251B (en)	2001-05-16
US6316425B1 (en)	2001-11-13
MX9800622A (es)	1998-11-30
GB9515279D0 (en)	1995-09-20
PL183601B1 (pl)	2002-06-28
HU224839B1 (en)	2006-03-28
KR19990035804A (ko)	1999-05-25
SK8098A3 (en)	1998-07-08
EP0842185A1 (en)	1998-05-20
CA2227533C (en)	2007-01-09
IL122942A (en)	2006-12-10
ES2166900T3 (es)	2002-05-01
AU6633596A (en)	1997-02-26
AU714814B2 (en)	2000-01-13
NO313985B1 (no)	2003-01-13
NO980296L (no)	1998-01-23

Publication	Publication Date	Title
JP5087052B2 (ja)	2012-11-28	改良された治療剤
KR100483256B1 (ko)	2005-04-15	젬시타빈 유도체
CA2140653A1 (en)	1994-03-03	Protein kinase inhibitors and related compounds combined with taxol
DK166830B1 (da)	1993-07-19	5-fluor-2'-deoxyuridin-3',5'-derivater, hydrater og salte heraf, fremgangsmaade til fremstilling af disse samt antitumorpraeparater indeholdende disse derivater
RU2194711C2 (ru)	2002-12-20	Производные гемцитабина
MXPA99006790A (en)	2000-01-21	Gemcitabine derivatives
NO318934B1 (no)	2005-05-30	Gemcitabinderivater

Legal Events

Date	Code	Title	Description
2014-04-02	MM4A	Patent lapsed due to non-payment of maintenance fees	Effective date: 20130712