SK280532B6 - Derivát 3-alkoxykarbonyltiadiazinónu, spôsob jeho - Google Patents

Derivát 3-alkoxykarbonyltiadiazinónu, spôsob jeho Download PDF

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Publication number: SK280532B6
Authority: SK; Slovakia
Prior art keywords: tetrahydro; methyl; quinolyl; dihydro; dimethoxybenzoyl
Prior art date: 1995-01-11

Application number

SK1652-95A

Other languages

English (en)

Slovak (sk)

Other versions

SK165295A3 (en

Inventor

Rochus Jonas

Ingeborg Lues

Norbert Beier

Klaus-Otto Minck

Original Assignee

Merck Patent Gesellschaft Mit Beschr�Nkter Haftung

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-01-11

Filing date

1995-12-27

Publication date

2000-03-13

1995-12-27 Application filed by Merck Patent Gesellschaft Mit Beschr�Nkter Haftung filed Critical Merck Patent Gesellschaft Mit Beschr�Nkter Haftung

1996-08-07 Publication of SK165295A3 publication Critical patent/SK165295A3/sk

2000-03-13 Publication of SK280532B6 publication Critical patent/SK280532B6/sk

Links

238000000034 method Methods 0.000 title claims abstract description 15
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239000008194 pharmaceutical composition Substances 0.000 title claims abstract description 8
150000003839 salts Chemical class 0.000 claims abstract description 17
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150000001875 compounds Chemical class 0.000 claims description 47
229910052757 nitrogen Inorganic materials 0.000 claims description 21
125000003754 ethoxycarbonyl group Chemical group C(=O)(OCC)* 0.000 claims description 15
125000004742 propyloxycarbonyl group Chemical group 0.000 claims description 10
125000004432 carbon atom Chemical group C* 0.000 claims description 8
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CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
XSTXAVWGXDQKEL-UHFFFAOYSA-N Trichloroethylene Chemical group ClC=C(Cl)Cl XSTXAVWGXDQKEL-UHFFFAOYSA-N 0.000 description 1
DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 1
WETWJCDKMRHUPV-UHFFFAOYSA-N acetyl chloride Chemical compound CC(Cl)=O WETWJCDKMRHUPV-UHFFFAOYSA-N 0.000 description 1
239000012346 acetyl chloride Substances 0.000 description 1
150000001266 acyl halides Chemical class 0.000 description 1
239000002671 adjuvant Substances 0.000 description 1
238000004220 aggregation Methods 0.000 description 1
230000002776 aggregation Effects 0.000 description 1
150000001298 alcohols Chemical class 0.000 description 1
125000002723 alicyclic group Chemical group 0.000 description 1
125000001931 aliphatic group Chemical group 0.000 description 1
239000003513 alkali Substances 0.000 description 1
229910001854 alkali hydroxide Inorganic materials 0.000 description 1
229910001860 alkaline earth metal hydroxide Inorganic materials 0.000 description 1
125000004453 alkoxycarbonyl group Chemical group 0.000 description 1
125000005278 alkyl sulfonyloxy group Chemical group 0.000 description 1
150000001408 amides Chemical class 0.000 description 1
RNLQIBCLLYYYFJ-UHFFFAOYSA-N amrinone Chemical compound N1C(=O)C(N)=CC(C=2C=CN=CC=2)=C1 RNLQIBCLLYYYFJ-UHFFFAOYSA-N 0.000 description 1
229960002105 amrinone Drugs 0.000 description 1
150000008064 anhydrides Chemical class 0.000 description 1
230000003288 anthiarrhythmic effect Effects 0.000 description 1
230000002785 anti-thrombosis Effects 0.000 description 1
239000007864 aqueous solution Substances 0.000 description 1
150000008378 aryl ethers Chemical class 0.000 description 1
125000003118 aryl group Chemical group 0.000 description 1
125000005279 aryl sulfonyloxy group Chemical group 0.000 description 1
WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid group Chemical group C(C1=CC=CC=C1)(=O)O WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 1
235000019445 benzyl alcohol Nutrition 0.000 description 1
150000003938 benzyl alcohols Chemical class 0.000 description 1
230000000740 bleeding effect Effects 0.000 description 1
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MIOPJNTWMNEORI-UHFFFAOYSA-N camphorsulfonic acid Chemical class C1CC2(CS(O)(=O)=O)C(=O)CC1C2(C)C MIOPJNTWMNEORI-UHFFFAOYSA-N 0.000 description 1
150000001720 carbohydrates Chemical class 0.000 description 1
235000014633 carbohydrates Nutrition 0.000 description 1
239000001768 carboxy methyl cellulose Substances 0.000 description 1
230000000747 cardiac effect Effects 0.000 description 1
239000000969 carrier Substances 0.000 description 1
239000001913 cellulose Substances 0.000 description 1
235000010980 cellulose Nutrition 0.000 description 1
229920002678 cellulose Polymers 0.000 description 1
150000008280 chlorinated hydrocarbons Chemical class 0.000 description 1
HRYZWHHZPQKTII-UHFFFAOYSA-N chloroethane Chemical compound CCCl HRYZWHHZPQKTII-UHFFFAOYSA-N 0.000 description 1
238000004587 chromatography analysis Methods 0.000 description 1
230000004087 circulation Effects 0.000 description 1
239000011248 coating agent Substances 0.000 description 1
238000000576 coating method Methods 0.000 description 1
229940110456 cocoa butter Drugs 0.000 description 1
235000019868 cocoa butter Nutrition 0.000 description 1
239000003086 colorant Substances 0.000 description 1
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239000006071 cream Substances 0.000 description 1
238000002425 crystallisation Methods 0.000 description 1
230000008025 crystallization Effects 0.000 description 1
WZHCOOQXZCIUNC-UHFFFAOYSA-N cyclandelate Chemical compound C1C(C)(C)CC(C)CC1OC(=O)C(O)C1=CC=CC=C1 WZHCOOQXZCIUNC-UHFFFAOYSA-N 0.000 description 1
230000009089 cytolysis Effects 0.000 description 1
235000005911 diet Nutrition 0.000 description 1
230000037213 diet Effects 0.000 description 1
125000004177 diethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
HPNMFZURTQLUMO-UHFFFAOYSA-N diethylamine Chemical compound CCNCC HPNMFZURTQLUMO-UHFFFAOYSA-N 0.000 description 1
125000001664 diethylamino group Chemical group [H]C([H])([H])C([H])([H])N(*)C([H])([H])C([H])([H])[H] 0.000 description 1
229940082657 digitalis glycosides Drugs 0.000 description 1
239000002552 dosage form Substances 0.000 description 1
239000000890 drug combination Substances 0.000 description 1
238000001035 drying Methods 0.000 description 1
230000000694 effects Effects 0.000 description 1
230000008030 elimination Effects 0.000 description 1
238000003379 elimination reaction Methods 0.000 description 1
239000003995 emulsifying agent Substances 0.000 description 1
239000000839 emulsion Substances 0.000 description 1
150000002170 ethers Chemical class 0.000 description 1
229960003750 ethyl chloride Drugs 0.000 description 1
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
238000001704 evaporation Methods 0.000 description 1
229950003499 fibrin Drugs 0.000 description 1
238000001914 filtration Methods 0.000 description 1
239000010419 fine particle Substances 0.000 description 1
235000011389 fruit/vegetable juice Nutrition 0.000 description 1
235000013773 glyceryl triacetate Nutrition 0.000 description 1
150000002334 glycols Chemical class 0.000 description 1
230000036541 health Effects 0.000 description 1
238000010438 heat treatment Methods 0.000 description 1
229930195733 hydrocarbon Natural products 0.000 description 1
150000002430 hydrocarbons Chemical class 0.000 description 1
125000004435 hydrogen atom Chemical group [H]* 0.000 description 1
XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical compound [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 description 1
WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 1
239000007943 implant Substances 0.000 description 1
238000001727 in vivo Methods 0.000 description 1
238000011065 in-situ storage Methods 0.000 description 1
230000002401 inhibitory effect Effects 0.000 description 1
230000005764 inhibitory process Effects 0.000 description 1
230000000297 inotrophic effect Effects 0.000 description 1
239000000543 intermediate Substances 0.000 description 1
125000004491 isohexyl group Chemical group C(CCC(C)C)* 0.000 description 1
125000001972 isopentyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])C([H])([H])* 0.000 description 1
125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
229940039717 lanolin Drugs 0.000 description 1
235000019388 lanolin Nutrition 0.000 description 1
239000000314 lubricant Substances 0.000 description 1
229940057948 magnesium stearate Drugs 0.000 description 1
AUHZEENZYGFFBQ-UHFFFAOYSA-N mesitylene Substances CC1=CC(C)=CC(C)=C1 AUHZEENZYGFFBQ-UHFFFAOYSA-N 0.000 description 1
125000001827 mesitylenyl group Chemical group [H]C1=C(C(*)=C(C([H])=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])[H] 0.000 description 1
125000005948 methanesulfonyloxy group Chemical group 0.000 description 1
229940016286 microcrystalline cellulose Drugs 0.000 description 1
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239000008108 microcrystalline cellulose Substances 0.000 description 1
150000007522 mineralic acids Chemical class 0.000 description 1
244000309715 mini pig Species 0.000 description 1
DNIAPMSPPWPWGF-UHFFFAOYSA-N monopropylene glycol Natural products CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 1
LNOPIUAQISRISI-UHFFFAOYSA-N n'-hydroxy-2-propan-2-ylsulfonylethanimidamide Chemical compound CC(C)S(=O)(=O)CC(N)=NO LNOPIUAQISRISI-UHFFFAOYSA-N 0.000 description 1
125000001280 n-hexyl group Chemical group C(CCCCC)* 0.000 description 1
125000000740 n-pentyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
150000002825 nitriles Chemical class 0.000 description 1
239000002674 ointment Substances 0.000 description 1
235000008390 olive oil Nutrition 0.000 description 1
239000004006 olive oil Substances 0.000 description 1
150000007524 organic acids Chemical class 0.000 description 1
235000005985 organic acids Nutrition 0.000 description 1
239000012074 organic phase Substances 0.000 description 1
239000003960 organic solvent Substances 0.000 description 1
230000003204 osmotic effect Effects 0.000 description 1
210000003540 papillary muscle Anatomy 0.000 description 1
238000007911 parenteral administration Methods 0.000 description 1
230000002093 peripheral effect Effects 0.000 description 1
229940066842 petrolatum Drugs 0.000 description 1
235000019271 petrolatum Nutrition 0.000 description 1
239000000546 pharmaceutical excipient Substances 0.000 description 1
230000000144 pharmacologic effect Effects 0.000 description 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
150000003016 phosphoric acids Chemical class 0.000 description 1
OXNIZHLAWKMVMX-UHFFFAOYSA-N picric acid Chemical class OC1=C([N+]([O-])=O)C=C([N+]([O-])=O)C=C1[N+]([O-])=O OXNIZHLAWKMVMX-UHFFFAOYSA-N 0.000 description 1
229920001223 polyethylene glycol Polymers 0.000 description 1
239000011591 potassium Substances 0.000 description 1
229910052700 potassium Inorganic materials 0.000 description 1
239000000843 powder Substances 0.000 description 1
239000003755 preservative agent Substances 0.000 description 1
125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
235000013772 propylene glycol Nutrition 0.000 description 1
125000005493 quinolyl group Chemical group 0.000 description 1
150000003254 radicals Chemical class 0.000 description 1
230000009467 reduction Effects 0.000 description 1
125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
150000003335 secondary amines Chemical class 0.000 description 1
239000000741 silica gel Substances 0.000 description 1
229910002027 silica gel Inorganic materials 0.000 description 1
239000000377 silicon dioxide Substances 0.000 description 1
235000012239 silicon dioxide Nutrition 0.000 description 1
239000011734 sodium Substances 0.000 description 1
229910052708 sodium Inorganic materials 0.000 description 1
WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 1
235000010234 sodium benzoate Nutrition 0.000 description 1
239000004299 sodium benzoate Substances 0.000 description 1
235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
229910052938 sodium sulfate Inorganic materials 0.000 description 1
235000011152 sodium sulphate Nutrition 0.000 description 1
239000007787 solid Substances 0.000 description 1
239000000600 sorbitol Substances 0.000 description 1
239000008347 soybean phospholipid Substances 0.000 description 1
208000010110 spontaneous platelet aggregation Diseases 0.000 description 1
239000003381 stabilizer Substances 0.000 description 1
235000019698 starch Nutrition 0.000 description 1
239000005720 sucrose Substances 0.000 description 1
150000003460 sulfonic acids Chemical class 0.000 description 1
150000003462 sulfoxides Chemical class 0.000 description 1
QAOWNCQODCNURD-UHFFFAOYSA-N sulfuric acid group Chemical class S(O)(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 1
239000000725 suspension Substances 0.000 description 1
239000006188 syrup Substances 0.000 description 1
235000020357 syrup Nutrition 0.000 description 1
239000000454 talc Substances 0.000 description 1
229940033134 talc Drugs 0.000 description 1
235000012222 talc Nutrition 0.000 description 1
229910052623 talc Inorganic materials 0.000 description 1
125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
150000003512 tertiary amines Chemical class 0.000 description 1
229940124597 therapeutic agent Drugs 0.000 description 1
230000001732 thrombotic effect Effects 0.000 description 1
238000011200 topical administration Methods 0.000 description 1
230000000699 topical effect Effects 0.000 description 1
URAYPUMNDPQOKB-UHFFFAOYSA-N triacetin Chemical compound CC(=O)OCC(OC(C)=O)COC(C)=O URAYPUMNDPQOKB-UHFFFAOYSA-N 0.000 description 1
229960002622 triacetin Drugs 0.000 description 1
230000000304 vasodilatating effect Effects 0.000 description 1
229940124549 vasodilator Drugs 0.000 description 1
239000003071 vasodilator agent Substances 0.000 description 1
235000015112 vegetable and seed oil Nutrition 0.000 description 1
239000008158 vegetable oil Substances 0.000 description 1
239000011782 vitamin Substances 0.000 description 1
229940088594 vitamin Drugs 0.000 description 1
229930003231 vitamin Natural products 0.000 description 1
235000013343 vitamin Nutrition 0.000 description 1
239000000080 wetting agent Substances 0.000 description 1
239000008096 xylene Substances 0.000 description 1
150000003738 xylenes Chemical class 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Hospice & Palliative Care (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Diabetes (AREA)
Hematology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

SK1652-95A 1995-01-11 1995-12-27 Derivát 3-alkoxykarbonyltiadiazinónu, spôsob jeho SK280532B6 (sk)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE19500558A DE19500558A1 (de)	1995-01-11	1995-01-11	3-Alkoxycarbonyl-thiadiazinone

Publications (2)

Publication Number	Publication Date
SK165295A3 SK165295A3 (en)	1996-08-07
SK280532B6 true SK280532B6 (sk)	2000-03-13

Family

ID=7751240

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SK1652-95A SK280532B6 (sk)	1995-01-11	1995-12-27	Derivát 3-alkoxykarbonyltiadiazinónu, spôsob jeho

Country Status (23)

Country	Link
US (1)	US5705497A (ko)
EP (1)	EP0721950B1 (ko)
JP (1)	JP4025377B2 (ko)
KR (1)	KR100399541B1 (ko)
CN (1)	CN1055691C (ko)
AT (1)	ATE165828T1 (ko)
AU (1)	AU704493B2 (ko)
CA (1)	CA2166854A1 (ko)
CZ (1)	CZ292094B6 (ko)
DE (2)	DE19500558A1 (ko)
DK (1)	DK0721950T3 (ko)
ES (1)	ES2120251T3 (ko)
GR (1)	GR3027566T3 (ko)
HU (1)	HUP9600061A3 (ko)
MX (1)	MX9600165A (ko)
NO (1)	NO306300B1 (ko)
PL (1)	PL183011B1 (ko)
RU (1)	RU2162087C2 (ko)
SI (1)	SI0721950T1 (ko)
SK (1)	SK280532B6 (ko)
TW (1)	TW407157B (ko)
UA (1)	UA44249C2 (ko)
ZA (1)	ZA96177B (ko)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE19533975A1 (de) *	1995-09-14	1997-03-20	Merck Patent Gmbh	Arylalkyl-diazinone
DE19929785A1 (de)	1999-06-29	2001-01-04	Bayer Ag	Tetrahydrochinolinyl-6-methyldihydrothiadiazinon-Derivate und ihre Verwendung
RU2395508C1 (ru) *	2006-05-24	2010-07-27	Лейбниц Инститьют Фор Нэчрал Продакт Рисерч Энд Инфекшн Байолоджи Е.В. Ганс-Кнёль-Институт (Хки)	Новые производные бензотиазинона и их применение в качестве антибактериальных средств
KR20170043581A (ko) *	2014-08-15	2017-04-21	에프. 호프만-라 로슈 아게	2,2,2-트라이플루오로에틸-티아다이아진
CN112500353B (zh) *	2020-12-08	2022-11-25	北京晨光同创医药研究院有限公司	一种左西孟旦的前药化合物、制备方法及其应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU614965B2 (en) *	1987-06-06	1991-09-19	Merck Patent Gesellschaft Mit Beschrankter Haftung	Thiadiazinones
GB8901836D0 (en) *	1989-01-27	1989-03-15	Sobio Lab	Compounds
SU1648949A1 (ru) *	1989-04-25	1991-05-15	Ленинградский Технологический Институт Им.Ленсовета	Способ получени 2,4,5-замещенных 4Н-1,3,4-тиадиазинов
DE4041074A1 (de) *	1990-12-21	1992-06-25	Merck Patent Gmbh	Thiadiazinonderivate
DE4129062A1 (de) *	1991-09-02	1993-03-04	Merck Patent Gmbh	Verfahren zur enantiomerentrennung von 5-hetaryl-1,3,4-thiadiazinonen
DE4134893A1 (de) *	1991-10-23	1993-04-29	Merck Patent Gmbh	Thiadiazinone
DE4223537A1 (de) *	1992-07-17	1994-01-20	Merck Patent Gmbh	Thiadiazinone
DE4310699A1 (de) *	1993-04-01	1994-10-06	Merck Patent Gmbh	Thiadiazinone

1995
- 1995-01-11 DE DE19500558A patent/DE19500558A1/de not_active Withdrawn
- 1995-12-27 SK SK1652-95A patent/SK280532B6/sk unknown
1996
- 1996-01-04 AU AU40826/96A patent/AU704493B2/en not_active Ceased
- 1996-01-05 SI SI9630017T patent/SI0721950T1/xx not_active IP Right Cessation
- 1996-01-05 DE DE59600173T patent/DE59600173D1/de not_active Expired - Fee Related
- 1996-01-05 DK DK96100093T patent/DK0721950T3/da active
- 1996-01-05 EP EP96100093A patent/EP0721950B1/de not_active Expired - Lifetime
- 1996-01-05 AT AT96100093T patent/ATE165828T1/de not_active IP Right Cessation
- 1996-01-05 ES ES96100093T patent/ES2120251T3/es not_active Expired - Lifetime
- 1996-01-09 MX MX9600165A patent/MX9600165A/es unknown
- 1996-01-09 CA CA002166854A patent/CA2166854A1/en not_active Abandoned
- 1996-01-09 CN CN96100838A patent/CN1055691C/zh not_active Expired - Fee Related
- 1996-01-10 CZ CZ199680A patent/CZ292094B6/cs not_active IP Right Cessation
- 1996-01-10 NO NO960112A patent/NO306300B1/no not_active IP Right Cessation
- 1996-01-10 UA UA96010108A patent/UA44249C2/uk unknown
- 1996-01-10 ZA ZA96177A patent/ZA96177B/xx unknown
- 1996-01-10 TW TW085100251A patent/TW407157B/zh not_active IP Right Cessation
- 1996-01-10 PL PL96312240A patent/PL183011B1/pl not_active IP Right Cessation
- 1996-01-10 RU RU96100853/04A patent/RU2162087C2/ru not_active IP Right Cessation
- 1996-01-10 HU HU9600061A patent/HUP9600061A3/hu unknown
- 1996-01-11 US US08/584,127 patent/US5705497A/en not_active Expired - Fee Related
- 1996-01-11 JP JP01924796A patent/JP4025377B2/ja not_active Expired - Fee Related
- 1996-01-11 KR KR1019960000414A patent/KR100399541B1/ko not_active Expired - Fee Related
1998
- 1998-08-04 GR GR980401750T patent/GR3027566T3/el unknown

Also Published As

Publication number	Publication date
RU2162087C2 (ru)	2001-01-20
HUP9600061A3 (en)	1998-04-28
NO306300B1 (no)	1999-10-18
SI0721950T1 (en)	1998-10-31
EP0721950B1 (de)	1998-05-06
CN1055691C (zh)	2000-08-23
KR100399541B1 (ko)	2003-12-31
ATE165828T1 (de)	1998-05-15
PL312240A1 (en)	1996-07-22
TW407157B (en)	2000-10-01
AU4082696A (en)	1996-07-18
CA2166854A1 (en)	1996-07-12
KR960029331A (ko)	1996-08-17
DE19500558A1 (de)	1996-07-18
NO960112L (no)	1996-07-12
PL183011B1 (pl)	2002-05-31
EP0721950A2 (de)	1996-07-17
MX9600165A (es)	1997-01-31
JP4025377B2 (ja)	2007-12-19
UA44249C2 (uk)	2002-02-15
CZ8096A3 (en)	1996-07-17
AU704493B2 (en)	1999-04-22
NO960112D0 (no)	1996-01-10
CN1135484A (zh)	1996-11-13
CZ292094B6 (cs)	2003-07-16
DE59600173D1 (de)	1998-06-10
HUP9600061A2 (en)	1997-10-28
ES2120251T3 (es)	1998-10-16
US5705497A (en)	1998-01-06
ZA96177B (en)	1996-07-30
HK1010194A1 (en)	1999-06-17
GR3027566T3 (en)	1998-11-30
SK165295A3 (en)	1996-08-07
DK0721950T3 (da)	1999-02-15
JPH08253478A (ja)	1996-10-01
EP0721950A3 (ko)	1996-07-24

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