SK279298B6 - Deriváty camptothecinu, spôsob ich výroby, farmace - Google Patents

Deriváty camptothecinu, spôsob ich výroby, farmace Download PDF

Info

Publication number: SK279298B6
Authority: SK; Slovakia
Prior art keywords: alkyl; camptothecin; ethylenedioxy; formula; compound
Prior art date: 1991-10-29

Application number

SK3237-92A

Other languages

English (en)

Slovak (sk)

Other versions

SK323792A3 (en

Inventor

Michael J. Luzzio

Jeffrey M. Besterman

Michael G. Evans

Peter L. Myers

Original Assignee

Glaxo Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-10-29

Filing date

1992-10-27

Publication date

1998-09-09

1992-10-27 Application filed by Glaxo Inc filed Critical Glaxo Inc

1998-09-09 Publication of SK323792A3 publication Critical patent/SK323792A3/sk

1998-09-09 Publication of SK279298B6 publication Critical patent/SK279298B6/sk

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
- C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
- C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D319/18—Ethylenedioxybenzenes, not substituted on the hetero ring
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
- C07D317/62—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring
- C07D317/66—Nitrogen atoms not forming part of a nitro radical

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)

SK3237-92A 1991-10-29 1992-10-27 Deriváty camptothecinu, spôsob ich výroby, farmace SK279298B6 (sk)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US78427591A	1991-10-29	1991-10-29
US82672992A	1992-01-28	1992-01-28

Publications (2)

Publication Number	Publication Date
SK323792A3 SK323792A3 (en)	1998-09-09
SK279298B6 true SK279298B6 (sk)	1998-09-09

Family

ID=27120258

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SK3237-92A SK279298B6 (sk)	1991-10-29	1992-10-27	Deriváty camptothecinu, spôsob ich výroby, farmace

Country Status (25)

Country	Link
EP (1)	EP0540099B1 (fi)
JP (2)	JP3020760B2 (fi)
KR (1)	KR100246154B1 (fi)
CN (1)	CN1072683A (fi)
AP (1)	AP306A (fi)
AT (1)	ATE136898T1 (fi)
AU (1)	AU657007B2 (fi)
CA (1)	CA2081580A1 (fi)
CZ (1)	CZ284023B6 (fi)
DE (1)	DE69209969T2 (fi)
DK (1)	DK0540099T3 (fi)
ES (1)	ES2086643T3 (fi)
FI (3)	FI104373B (fi)
GR (1)	GR3020120T3 (fi)
HU (2)	HU217970B (fi)
IL (1)	IL103571A (fi)
IS (1)	IS1708B (fi)
MX (1)	MX9206211A (fi)
MY (1)	MY108261A (fi)
NO (1)	NO302073B1 (fi)
NZ (1)	NZ244914A (fi)
OA (1)	OA09767A (fi)
RU (1)	RU2119921C1 (fi)
SK (1)	SK279298B6 (fi)
TW (1)	TW221994B (fi)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
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US5364858A (en) *	1987-03-31	1994-11-15	Research Triangle Institute	Camptothecin analogs as potent inhibitors of topoisomerase I
US5552154A (en)	1989-11-06	1996-09-03	The Stehlin Foundation For Cancer Research	Method for treating cancer with water-insoluble s-camptothecin of the closed lactone ring form and derivatives thereof
US6080751A (en) *	1992-01-14	2000-06-27	The Stehlin Foundation For Cancer Research	Method for treating pancreatic cancer in humans with water-insoluble S-camptothecin of the closed lactone ring form and derivatives thereof
AP9300587A0 (en) *	1992-11-12	1995-05-05	Glaxo Inc	Water soluble camptothecin derivatives.
DE69431731T2 (de) *	1993-01-15	2003-03-13	The Stehlin Foundation For Cancer Research, Houston	Orale oder intramuskuläre Behandlung von Pankreaskrebs durch wasserunlösliches S-Camptothecin mit geschlossenem Lactonring
US5369127A (en) *	1993-04-21	1994-11-29	Allergan, Inc.	1,3-benzodioxole and 1,2-dialkoxybenzene derivatives as ocular hypotensive agents
IS4152A (is) *	1993-04-29	1994-10-30	Glaxo Inc.	Vatnsuppleysanlegar Camptothecin afleiður og aðferð til framleiðslu þeirra
EP0699201A1 (en) *	1993-05-03	1996-03-06	Smithkline Beecham Corporation	SUBSTITUTED METHYLENEDIOXY 3',4':6,7]INDOLIZINO- 1,2-$i(b)]QUINOLINONES
US5447936A (en) *	1993-12-22	1995-09-05	Bionumerik Pharmaceuticals, Inc.	Lactone stable formulation of 10-hydroxy 7-ethyl camptothecin and methods for uses thereof
US5491237A (en)	1994-05-03	1996-02-13	Glaxo Wellcome Inc.	Intermediates in pharmaceutical camptothecin preparation
IT1269862B (it) *	1994-05-30	1997-04-15	Indena Spa	Alcaloidi da mappia foetida, loro uso e formulazioni che li contengono
US5646159A (en) *	1994-07-20	1997-07-08	Research Triangle Institute	Water-soluble esters of camptothecin compounds
KR960029336A (ko) *	1995-01-09	1996-08-17	김충환	캄토테신 유도체, 그의 제조 방법 및 이를 함유하는 항암제
US5496952A (en) *	1995-02-07	1996-03-05	North Carolina State University	Method of making asymmetric DE ring intermediates for the synthesis of camptothecin and camptothecin analogs
US5670500A (en) *	1995-05-31	1997-09-23	Smithkline Beecham Corporation	Water soluble camptothecin analogs
WO1997001539A1 (en) *	1995-06-27	1997-01-16	Takeda Chemical Industries, Ltd.	4-acylamino(halogeno) alkyl-quinoline derivatives, their preparation and their use as melatonin agonists
SG50747A1 (en) *	1995-08-02	1998-07-20	Tanabe Seiyaku Co	Comptothecin derivatives
WO1997019085A1 (en) *	1995-11-22	1997-05-29	Research Triangle Institute	Camptothecin compounds with combined topoisomerase i inhibition and dna alkylation properties
CA2192725C (en)	1995-12-28	2004-04-20	Kenji Tsujihara	Camptothecin derivatives
SG116433A1 (en) *	1996-10-30	2005-11-28	Tanabe Seiyaku Co	S type 2-substituted hydroxy-2-indolidinylbutyric ester compounds and process for preparation thereof.
US6559309B2 (en) *	1996-11-01	2003-05-06	Osi Pharmaceuticals, Inc.	Preparation of a camptothecin derivative by intramolecular cyclisation
US6207673B1 (en)	1997-03-12	2001-03-27	The University Of North Carolina At Chapel Hill	Covalent conjugates of topoisomerase I and topoisomerase II inhibitors
US6046209A (en) *	1997-05-27	2000-04-04	Smithkline Beecham Corporation	Water soluble camptothecin analogs
US6288072B1 (en) *	1999-12-29	2001-09-11	Monroe E. Wall	Camptothecin β-alanine esters with topoisomerase I inhibition
CN1424912A (zh)	2000-02-28	2003-06-18	阿文蒂斯药物股份有限公司	用于治疗癌症的含有喜树碱和嘧啶衍生物的组合物
US6548488B2 (en)	2000-03-17	2003-04-15	Aventis Pharma S.A.	Composition comprising camptothecin or a camptothecin derivative and an alkylating agent for the treatment of cancer
US6545010B2 (en)	2000-03-17	2003-04-08	Aventis Pharma S.A.	Composition comprising camptothecin or a camptothecin derivative and a platin derivative for the treatment of cancer
US6486320B2 (en)	2000-09-15	2002-11-26	Aventis Pharma S.A.	Preparation of camptothecin and of its derivatives
HUP0302629A3 (en)	2000-10-27	2005-05-30	Aventis Pharma Sa	Pharmaceutical compositions comprising a combination camptothecin and a stilbene derivative for the treatment of cancer
ITRM20040240A1 (it) *	2004-05-13	2004-08-13	Ist Naz Stud Cura Dei Tumori	Camptotecine coniugate in posizione 7 con antagonisti delle integrine.
WO2006069344A2 (en)	2004-12-22	2006-06-29	Rutgers, The State University Of New Jersey	Controlled release hydrogels
KR101394768B1 (ko)	2006-03-30	2014-05-21	드라이스 파마슈티컬스 아이엔씨	캄토테신-세포 투과 펩티드 결합체 및 이를 포함하는 약학 조성물
CN101407524B (zh) *	2007-10-09	2012-07-18	江苏先声药物研究有限公司	噁嗪骈喜树碱衍生物及其制备方法和用途
CN100592871C (zh) *	2008-03-14	2010-03-03	浙江林学院	一种杀虫剂组合物及其加工方法
ES2373172B1 (es) *	2010-07-16	2012-12-10	Consejo Superior De Investigaciones Científicas (Csic)	Proceso de obtención de derivados solubles en agua de 20 (s) camptotecina como agentes antitumorales.
US20140086975A1 (en)	2010-10-15	2014-03-27	Rutgers, The State University Of New Jersey	Hydrogel formulation for dermal and ocular delivery
US8980909B2 (en)	2011-01-12	2015-03-17	Crystal Biopharmaceutical Llc	HDAC inhibiting derivatives of camptothecin
AR114473A1 (es) *	2018-04-06	2020-09-09	Seattle Genetics Inc	Conjugados péptido-camptotecina
TWI851577B (zh)	2018-06-07	2024-08-11	美商思進公司	喜樹鹼結合物
CN110590796B (zh) *	2018-06-12	2022-07-15	青岛海洋生物医药研究院股份有限公司	喜树碱衍生物及其制备方法和应用
CA3228345A1 (en) *	2021-08-19	2023-02-23	Zhen Li	Camptothecin derivative, and pharmaceutical composition and use thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5004758A (en) *	1987-12-01	1991-04-02	Smithkline Beecham Corporation	Water soluble camptothecin analogs useful for inhibiting the growth of animal tumor cells

1992
- 1992-10-23 DK DK92203263.6T patent/DK0540099T3/da active
- 1992-10-23 ES ES92203263T patent/ES2086643T3/es not_active Expired - Lifetime
- 1992-10-23 EP EP92203263A patent/EP0540099B1/en not_active Expired - Lifetime
- 1992-10-23 AT AT92203263T patent/ATE136898T1/de not_active IP Right Cessation
- 1992-10-23 DE DE69209969T patent/DE69209969T2/de not_active Expired - Fee Related
- 1992-10-27 SK SK3237-92A patent/SK279298B6/sk unknown
- 1992-10-27 CZ CS923237A patent/CZ284023B6/cs not_active IP Right Cessation
- 1992-10-27 TW TW081108539A patent/TW221994B/zh active
- 1992-10-28 FI FI924878A patent/FI104373B/fi active
- 1992-10-28 OA OA60295A patent/OA09767A/en unknown
- 1992-10-28 AP APAP/P/1992/000439A patent/AP306A/en active
- 1992-10-28 CA CA002081580A patent/CA2081580A1/en not_active Abandoned
- 1992-10-28 KR KR1019920019884A patent/KR100246154B1/ko not_active Expired - Fee Related
- 1992-10-28 MY MYPI92001954A patent/MY108261A/en unknown
- 1992-10-28 HU HU9203384A patent/HU217970B/hu not_active IP Right Cessation
- 1992-10-28 IS IS3936A patent/IS1708B/is unknown
- 1992-10-28 NO NO924158A patent/NO302073B1/no unknown
- 1992-10-28 AU AU27385/92A patent/AU657007B2/en not_active Ceased
- 1992-10-28 JP JP4312862A patent/JP3020760B2/ja not_active Expired - Fee Related
- 1992-10-28 NZ NZ244914A patent/NZ244914A/xx not_active IP Right Cessation
- 1992-10-28 CN CN92113782A patent/CN1072683A/zh not_active Withdrawn
- 1992-10-28 MX MX9206211A patent/MX9206211A/es unknown
- 1992-10-28 RU RU92004336A patent/RU2119921C1/ru not_active IP Right Cessation
- 1992-10-28 IL IL103571A patent/IL103571A/en not_active IP Right Cessation
1995
- 1995-06-14 HU HU95P/P00203P patent/HU211349A9/hu unknown
1996
- 1996-05-31 GR GR960401497T patent/GR3020120T3/el unknown
1998
- 1998-10-08 FI FI982185A patent/FI982185L/fi unknown
1999
- 1999-11-02 JP JP31294099A patent/JP3229298B2/ja not_active Expired - Fee Related
2002
- 2002-06-07 FI FI20021090A patent/FI20021090L/fi not_active Application Discontinuation

Also Published As

Publication number	Publication date
IS1708B (is)	1998-12-16
FI924878A0 (fi)	1992-10-28
IL103571A0 (en)	1993-03-15
SK323792A3 (en)	1998-09-09
FI104373B (fi)	2000-01-14
MX9206211A (es)	1993-05-01
FI982185A0 (fi)	1998-10-08
AP9200439A0 (en)	1992-10-31
AP306A (en)	1994-01-28
AU657007B2 (en)	1995-02-23
DE69209969T2 (de)	1996-09-12
HU217970B (hu)	2000-05-28
RU2119921C1 (ru)	1998-10-10
FI982185L (fi)	1998-10-08
MY108261A (en)	1996-09-30
JP3020760B2 (ja)	2000-03-15
NO924158L (no)	1993-04-30
HUT65719A (en)	1994-07-28
NO924158D0 (no)	1992-10-28
OA09767A (en)	1993-11-30
NO302073B1 (no)	1998-01-19
JPH05222048A (ja)	1993-08-31
GR3020120T3 (en)	1996-08-31
AU2738592A (en)	1993-05-06
CA2081580A1 (en)	1993-04-30
DE69209969D1 (de)	1996-05-23
TW221994B (fi)	1994-04-01
NZ244914A (en)	1995-01-27
IS3936A (is)	1993-04-30
KR100246154B1 (ko)	2000-04-01
FI20021090L (fi)	2002-06-07
CZ323792A3 (en)	1993-10-13
ES2086643T3 (es)	1996-07-01
HU211349A9 (en)	1995-11-28
HU9203384D0 (en)	1993-01-28
CZ284023B6 (cs)	1998-07-15
DK0540099T3 (da)	1996-06-17
ATE136898T1 (de)	1996-05-15
EP0540099A1 (en)	1993-05-05
FI924878A (fi)	1993-04-30
IL103571A (en)	1998-01-04
JP2000109475A (ja)	2000-04-18
JP3229298B2 (ja)	2001-11-19
CN1072683A (zh)	1993-06-02
EP0540099B1 (en)	1996-04-17

Publication	Publication Date	Title
SK279298B6 (sk)	1998-09-09	Deriváty camptothecinu, spôsob ich výroby, farmace
US5342947A (en)	1994-08-30	Preparation of water soluble camptothecin derivatives
US5559235A (en)	1996-09-24	Water soluble camptothecin derivatives
AU652728B2 (en)	1994-09-08	Camptothecin analogs as potent inhibitors of human colorectal cancer
US6100273A (en)	2000-08-08	Water soluble camptothecin derivatives
US4894456A (en)	1990-01-16	Synthesis of camptothecin and analogs thereof
US5122526A (en)	1992-06-16	Camptothecin and analogs thereof and pharmaceutical compositions and method using them
US5401747A (en)	1995-03-28	Alkyl camptothecin compounds as potent inhibitors of human colorectal cancer
EP0436653A1 (en)	1991-07-17	Synthesis of camptothecin and analogs thereof
CN1090634C (zh)	2002-09-11	喜树碱的前药形式和类似物,及其药物用途
US5227380A (en)	1993-07-13	Pharmaceutical compositions and methods employing camptothecins
HU204052B (en)	1991-11-28	Process for producing imidazopyridazines and pharmaceutical comprising such compounds
EP0696285A1 (en)	1996-02-14	Water soluble derivatives of camptothecin and their use as antitumor agents
SI9300183A (sl)	1994-12-31	Vodotopni kamptotecinski derivati
PL173684B1 (pl)	1998-04-30	Pochodne kamptotecyny i sposób wytwarzania pochodnych kamptofecyny
FR2826009A1 (fr)	2002-12-20	Nouveaux derives d'indenoindolones, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
JPH0834788A (ja)	1996-02-06	ピロロベンゾカルバゾール誘導体及びその製造方法