[go: up one dir, main page]

SK17052001A3 - Substituované amidy kyseliny fenylcyklohexánkarboxylovej, spôsob ich výroby, liečivá tieto látky obsahujúce a ich použitie - Google Patents

Substituované amidy kyseliny fenylcyklohexánkarboxylovej, spôsob ich výroby, liečivá tieto látky obsahujúce a ich použitie Download PDF

Info

Publication number
SK17052001A3
SK17052001A3 SK1705-2001A SK17052001A SK17052001A3 SK 17052001 A3 SK17052001 A3 SK 17052001A3 SK 17052001 A SK17052001 A SK 17052001A SK 17052001 A3 SK17052001 A3 SK 17052001A3
Authority
SK
Slovakia
Prior art keywords
carbon atoms
formula
optionally
compounds
group
Prior art date
Application number
SK1705-2001A
Other languages
English (en)
Slovak (sk)
Inventor
Wolf-Dietrich Freund
Stephen Lensky
Stephan Nicholas M�LLER
Holger Paulsen
Jrg Keldenich
Ervin Horv�Th
Joachim Schuhmacher
Original Assignee
Bayer Aktiengesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Aktiengesellschaft filed Critical Bayer Aktiengesellschaft
Publication of SK17052001A3 publication Critical patent/SK17052001A3/sk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/16—Central respiratory analeptics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/14—Radicals substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/18—Benzimidazoles; Hydrogenated benzimidazoles with aryl radicals directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/30—Nitrogen atoms not forming part of a nitro radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Ophthalmology & Optometry (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Vascular Medicine (AREA)
  • Anesthesiology (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
SK1705-2001A 1999-05-29 2000-05-16 Substituované amidy kyseliny fenylcyklohexánkarboxylovej, spôsob ich výroby, liečivá tieto látky obsahujúce a ich použitie SK17052001A3 (sk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19924818A DE19924818A1 (de) 1999-05-29 1999-05-29 Substituierte Phenylcyclohexancarbonsäureamide
PCT/EP2000/004417 WO2000073275A1 (de) 1999-05-29 2000-05-16 Substituierte phenylcyclohexancarbonsäureamide mit adenosinaufnahme-hemmender wirkung

Publications (1)

Publication Number Publication Date
SK17052001A3 true SK17052001A3 (sk) 2002-06-04

Family

ID=7909712

Family Applications (1)

Application Number Title Priority Date Filing Date
SK1705-2001A SK17052001A3 (sk) 1999-05-29 2000-05-16 Substituované amidy kyseliny fenylcyklohexánkarboxylovej, spôsob ich výroby, liečivá tieto látky obsahujúce a ich použitie

Country Status (36)

Country Link
US (2) US6716849B1 (pt)
EP (1) EP1185516B1 (pt)
JP (1) JP2003500475A (pt)
KR (1) KR20020003397A (pt)
CN (1) CN1200932C (pt)
AR (1) AR024100A1 (pt)
AT (1) ATE238997T1 (pt)
AU (1) AU765752B2 (pt)
BG (1) BG106107A (pt)
BR (1) BR0011061A (pt)
CA (1) CA2375186A1 (pt)
CZ (1) CZ20014288A3 (pt)
DE (2) DE19924818A1 (pt)
DK (1) DK1185516T3 (pt)
EE (1) EE200100634A (pt)
ES (1) ES2197870T3 (pt)
GT (1) GT200000083A (pt)
HK (1) HK1048810A1 (pt)
HN (1) HN2000000072A (pt)
HR (1) HRP20010955A2 (pt)
HU (1) HUP0201350A3 (pt)
IL (1) IL146392A0 (pt)
MA (1) MA25414A1 (pt)
MX (1) MXPA01012241A (pt)
MY (1) MY122576A (pt)
NO (1) NO20015810L (pt)
PE (1) PE20010167A1 (pt)
PL (1) PL352101A1 (pt)
PT (1) PT1185516E (pt)
RU (1) RU2246490C9 (pt)
SI (1) SI1185516T1 (pt)
SK (1) SK17052001A3 (pt)
SV (1) SV2004000087A (pt)
UA (1) UA73126C2 (pt)
WO (1) WO2000073275A1 (pt)
ZA (1) ZA200109263B (pt)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1834090B (zh) * 2005-03-18 2011-06-29 中国科学院上海药物研究所 苯并咪唑类化合物、其制备方法以及用途
RU2524212C2 (ru) * 2008-06-16 2014-07-27 Бёрингер Ингельхайм Интернациональ Гмбх Способ получения промежуточного продукта для синтеза этексилата дабигатрана
EP2858983B1 (en) 2012-06-11 2018-04-18 UCB Biopharma SPRL Tnf-alpha modulating benzimidazoles
CA3120941A1 (en) * 2018-11-25 2020-05-28 Tnt Medical Corporation Orally active prodrug of gemcitabine

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2685918B1 (fr) 1992-01-08 1995-06-23 Union Pharma Scient Appl Nouveaux derives de l'adenosine, leurs procedes de preparation, compositions pharmaceutiques les contenant.
DE4221009A1 (de) 1992-06-26 1994-01-05 Bayer Ag Imidazolyl-substituierte Cyclohexanderivate
DK0582164T3 (da) 1992-07-31 1999-08-23 Bristol Myers Squibb Co Adenosin-genoptagelsesinhiberende derivater af diphenyloxazoler, -thiazoler og -imidazoler
DE4304455A1 (de) 1993-02-15 1994-08-18 Bayer Ag Heterocyclisch substituierte Phenyl-cyclohexan-carbonsäurederivate
DE4401893A1 (de) 1994-01-24 1995-07-27 Bayer Ag Substituierte Arylharnstoffe
HRP960015B1 (en) 1995-02-01 2000-12-31 Bayer Ag Substituted indole derivatives
DE19503160A1 (de) 1995-02-01 1996-08-08 Bayer Ag Verwendung von Phenylcyclohexylcarbonsäureamiden

Also Published As

Publication number Publication date
GT200000083A (es) 2001-11-17
KR20020003397A (ko) 2002-01-12
ES2197870T3 (es) 2004-01-16
CN1200932C (zh) 2005-05-11
HN2000000072A (es) 2001-02-02
PL352101A1 (en) 2003-07-28
SI1185516T1 (en) 2003-10-31
HRP20010955A2 (en) 2003-08-31
CA2375186A1 (en) 2000-12-07
DK1185516T3 (da) 2003-08-11
NO20015810L (no) 2002-01-25
DE19924818A1 (de) 2000-11-30
HK1048810A1 (zh) 2003-04-17
HUP0201350A2 (en) 2002-08-28
EP1185516A1 (de) 2002-03-13
WO2000073275A1 (de) 2000-12-07
JP2003500475A (ja) 2003-01-07
MY122576A (en) 2006-04-29
CN1365356A (zh) 2002-08-21
US20040186106A1 (en) 2004-09-23
NO20015810D0 (no) 2001-11-28
US6716849B1 (en) 2004-04-06
AU765752B2 (en) 2003-09-25
MA25414A1 (fr) 2002-04-01
IL146392A0 (en) 2002-07-25
HUP0201350A3 (en) 2003-05-28
MXPA01012241A (es) 2002-08-12
ZA200109263B (en) 2003-01-29
BG106107A (bg) 2002-05-31
AR024100A1 (es) 2002-09-04
RU2246490C9 (ru) 2005-09-20
PT1185516E (pt) 2003-09-30
SV2004000087A (es) 2004-05-07
PE20010167A1 (es) 2001-04-25
DE50001982D1 (de) 2003-06-05
RU2246490C2 (ru) 2005-02-20
ATE238997T1 (de) 2003-05-15
EP1185516B1 (de) 2003-05-02
AU4405500A (en) 2000-12-18
UA73126C2 (en) 2005-06-15
CZ20014288A3 (cs) 2002-03-13
BR0011061A (pt) 2002-03-05
EE200100634A (et) 2003-02-17

Similar Documents

Publication Publication Date Title
KR100903531B1 (ko) 티오벤즈이미다졸 유도체
KR101346823B1 (ko) 헤테로시클릭 화합물
CA2088761C (en) Benzimidazole derivatives, process for their preparation and application
NZ232659A (en) Substituted benzimidazoles, pharmaceutical compositions and intermediates
BRPI0610150A2 (pt) composto, pró-droga, processo para produzir o composto, composição farmacêutica, antagonista do receptor de crf, e, uso do antagonista do receptor de crf
AU2009221583A2 (en) Inhibitors of protein tyrosine kinase activity
CA2543707A1 (en) Nitrogen-containing fused heterocyclic compounds
JP2006528621A (ja) Ｎ−メチル−置換ベンゾアミダゾール
DE4408497A1 (de) Benzimidazole, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
SK17052001A3 (sk) Substituované amidy kyseliny fenylcyklohexánkarboxylovej, spôsob ich výroby, liečivá tieto látky obsahujúce a ich použitie
SK279409B6 (sk) Benzimidazoly, spôsob ich výroby a liečivo s ich o
CA3005614A1 (en) Aminonaphthoquinone compounds for treatment and/or prevention of fibrosis diseases
AU766140B2 (en) Substituted phenylcyclohexane carboxylic acid amides and their use as adenosine uptake inhibitors
TW202411233A (zh) 用於治療trpm3介導病症之新型衍生物
DE60113248T2 (de) Vitronektin rezeptor antagonisten
JP2004508350A (ja) 置換フェニルシクロヘキサンカルボン酸アミドおよびその使用
AU2023276867A1 (en) New derivatives for treating trpm3 mediated disorders
JP2003535088A (ja) ２，７−ナフチリジン誘導体