SK170299A3 - Aminospiro piperidine quinazoline derivatives, process and intermediates to their preparation, pharmaceutical compositions them containing and their use - Google Patents

Aminospiro piperidine quinazoline derivatives, process and intermediates to their preparation, pharmaceutical compositions them containing and their use Download PDF

Info

Publication number: SK170299A3
Authority: SK; Slovakia
Prior art keywords: amino; tetrahydrospiro; fluoro; quinazoline; pyrido
Prior art date: 1997-07-01

Application number

SK1702-99A

Other languages

English (en)

Slovak (sk)

Inventor

Peter Hamley

Austen Pimm

Alan Tinker

Original Assignee

Astra Pharma Prod

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-07-01

Filing date

1998-06-22

Publication date

2000-08-14

1998-06-22 Application filed by Astra Pharma Prod filed Critical Astra Pharma Prod

2000-08-14 Publication of SK170299A3 publication Critical patent/SK170299A3/sk

Links

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238000000034 method Methods 0.000 title claims abstract description 30
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239000008194 pharmaceutical composition Substances 0.000 title claims description 8
239000000543 intermediate Substances 0.000 title description 8
WOZWCUHQXLQIRZ-UHFFFAOYSA-N piperidine;quinazoline Chemical class C1CCNCC1.N1=CN=CC2=CC=CC=C21 WOZWCUHQXLQIRZ-UHFFFAOYSA-N 0.000 title 1
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238000001990 intravenous administration Methods 0.000 description 1
PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 description 1
239000003456 ion exchange resin Substances 0.000 description 1
229920003303 ion-exchange polymer Polymers 0.000 description 1
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125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 description 1
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238000004519 manufacturing process Methods 0.000 description 1
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QVNYNHCNNGKULA-UHFFFAOYSA-N methyl 2-amino-5-bromobenzoate Chemical compound COC(=O)C1=CC(Br)=CC=C1N QVNYNHCNNGKULA-UHFFFAOYSA-N 0.000 description 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
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150000007522 mineralic acids Chemical class 0.000 description 1
238000002156 mixing Methods 0.000 description 1
125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
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230000003287 optical effect Effects 0.000 description 1
210000000056 organ Anatomy 0.000 description 1
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239000003960 organic solvent Substances 0.000 description 1
125000002524 organometallic group Chemical group 0.000 description 1
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239000001301 oxygen Substances 0.000 description 1
UVBXZOISXNZBLY-UHFFFAOYSA-L palladium(2+);triphenylphosphane;diacetate Chemical compound [Pd+2].CC([O-])=O.CC([O-])=O.C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1.C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1 UVBXZOISXNZBLY-UHFFFAOYSA-L 0.000 description 1
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230000002085 persistent effect Effects 0.000 description 1
239000000546 pharmaceutical excipient Substances 0.000 description 1
239000002798 polar solvent Substances 0.000 description 1
229910052700 potassium Inorganic materials 0.000 description 1
239000011591 potassium Substances 0.000 description 1
230000003389 potentiating effect Effects 0.000 description 1
239000002244 precipitate Substances 0.000 description 1
230000001376 precipitating effect Effects 0.000 description 1
UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
208000024981 pyrosis Diseases 0.000 description 1
239000011541 reaction mixture Substances 0.000 description 1
230000029865 regulation of blood pressure Effects 0.000 description 1
230000004648 relaxation of smooth muscle Effects 0.000 description 1
238000011160 research Methods 0.000 description 1
208000023504 respiratory system disease Diseases 0.000 description 1
238000004007 reversed phase HPLC Methods 0.000 description 1
239000000523 sample Substances 0.000 description 1
208000012672 seasonal affective disease Diseases 0.000 description 1
238000000926 separation method Methods 0.000 description 1
229910052708 sodium Inorganic materials 0.000 description 1
235000010288 sodium nitrite Nutrition 0.000 description 1
AKHNMLFCWUSKQB-UHFFFAOYSA-L sodium thiosulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=S AKHNMLFCWUSKQB-UHFFFAOYSA-L 0.000 description 1
235000019345 sodium thiosulphate Nutrition 0.000 description 1
HPALAKNZSZLMCH-UHFFFAOYSA-M sodium;chloride;hydrate Chemical compound O.[Na+].[Cl-] HPALAKNZSZLMCH-UHFFFAOYSA-M 0.000 description 1
239000007909 solid dosage form Substances 0.000 description 1
239000011877 solvent mixture Substances 0.000 description 1
238000010561 standard procedure Methods 0.000 description 1
239000000126 substance Substances 0.000 description 1
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QAOWNCQODCNURD-UHFFFAOYSA-N sulfuric acid Substances OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 1
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208000024891 symptom Diseases 0.000 description 1
208000011580 syndromic disease Diseases 0.000 description 1
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230000000699 topical effect Effects 0.000 description 1
230000001988 toxicity Effects 0.000 description 1
231100000419 toxicity Toxicity 0.000 description 1
DBGVGMSCBYYSLD-UHFFFAOYSA-N tributylstannane Chemical compound CCCC[SnH](CCCC)CCCC DBGVGMSCBYYSLD-UHFFFAOYSA-N 0.000 description 1
230000002792 vascular Effects 0.000 description 1
125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/20—Spiro-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/20—Spiro-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed systems contains four or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pain & Pain Management (AREA)
Pulmonology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Rheumatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

SK1702-99A 1997-07-01 1998-06-22 Aminospiro piperidine quinazoline derivatives, process and intermediates to their preparation, pharmaceutical compositions them containing and their use SK170299A3 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
SE9702534A SE9702534D0 (sv)	1997-07-01	1997-07-01	Compounds
PCT/SE1998/001206 WO1999001455A1 (en)	1997-07-01	1998-06-22	Compounds

Publications (1)

Publication Number	Publication Date
SK170299A3 true SK170299A3 (en)	2000-08-14

Family

ID=20407595

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SK1702-99A SK170299A3 (en)	1997-07-01	1998-06-22	Aminospiro piperidine quinazoline derivatives, process and intermediates to their preparation, pharmaceutical compositions them containing and their use

Country Status (21)

Country	Link
US (2)	US6083952A (no)
EP (1)	EP1000064A1 (no)
JP (1)	JP2002507987A (no)
KR (1)	KR20010014367A (no)
CN (1)	CN1268138A (no)
AR (1)	AR013004A1 (no)
AU (1)	AU729792B2 (no)
BR (1)	BR9810214A (no)
CA (1)	CA2294734A1 (no)
EE (1)	EE9900602A (no)
HU (1)	HUP0003104A3 (no)
ID (1)	ID25585A (no)
IL (1)	IL133729A0 (no)
IS (1)	IS5323A (no)
NO (1)	NO996544L (no)
PL (1)	PL337536A1 (no)
SE (1)	SE9702534D0 (no)
SK (1)	SK170299A3 (no)
TR (1)	TR199903296T2 (no)
WO (1)	WO1999001455A1 (no)
ZA (1)	ZA985326B (no)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SK12672001A3 (sk)	1999-12-08	2002-04-04	Pharmacia Corporation	Zloženia inhibítora cyklooxygenázy-2 s rýchlym nástupom terapeutického účinku
JP2002073760A (ja) *	2000-08-28	2002-03-12	Tadakatsu Yoshida	貿易統合システム
AR038957A1 (es)	2001-08-15	2005-02-02	Pharmacia Corp	Terapia de combinacion para el tratamiento del cancer
AU2003213266A1 (en) *	2002-03-06	2003-09-22	Smithkline Beecham Corporation	Condensed heterocyclic compounds as calcitonin agonists
US20040063751A1 (en) *	2002-05-31	2004-04-01	Pharmacia Corporation	Combination therapy for the treatment of amyotrophic lateral sclerosis (ALS) with cyclooxygenase-2 (COX-2) inhibitor(s) and a second drug
CN112225662A (zh) *	2020-11-16	2021-01-15	苏州华鑫医药科技有限公司	一种邻碘苯甲酸的制备方法
IL305573A (en)	2021-03-15	2023-10-01	Saul Yedgar	HYALURONIC ACID-CONJUGATED DIPALMITOYL PHOSPHATIDYL ETHANOLAMINE IN COMBINATION WITH NON-STEROIDAL ANTI-INFLAMMATORY DRUGS (NSAIDs) FOR TREATING OR ALLEVIATING INFLAMMATORY DISEASES
CN114773316B (zh) *	2022-06-17	2022-10-25	上海睿跃生物科技有限公司	2-(2,6-二氧代-哌啶-3-基)-5-氟-异吲哚-1,3-二酮的制备方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3761480A (en) *	1968-07-10	1973-09-25	Pennwalt Corp	Process for the preparation of 3-aryl-6-sulfamyl-7-halo-1,2,3,4-tetrahydro-4-quinazolinones
AU704133B2 (en) *	1995-10-17	1999-04-15	Astrazeneca Ab	Pharmaceutically active quinazoline compounds

1997
- 1997-07-01 SE SE9702534A patent/SE9702534D0/xx unknown
1998
- 1998-06-18 ZA ZA985326A patent/ZA985326B/xx unknown
- 1998-06-18 AR ARP980102919A patent/AR013004A1/es unknown
- 1998-06-22 EP EP98931170A patent/EP1000064A1/en not_active Ceased
- 1998-06-22 PL PL98337536A patent/PL337536A1/xx unknown
- 1998-06-22 US US09/125,174 patent/US6083952A/en not_active Expired - Fee Related
- 1998-06-22 WO PCT/SE1998/001206 patent/WO1999001455A1/en not_active Application Discontinuation
- 1998-06-22 JP JP50700699A patent/JP2002507987A/ja active Pending
- 1998-06-22 HU HU0003104A patent/HUP0003104A3/hu unknown
- 1998-06-22 CA CA002294734A patent/CA2294734A1/en not_active Abandoned
- 1998-06-22 ID IDW991642A patent/ID25585A/id unknown
- 1998-06-22 EE EEP199900602A patent/EE9900602A/xx unknown
- 1998-06-22 BR BR9810214-1A patent/BR9810214A/pt not_active IP Right Cessation
- 1998-06-22 TR TR1999/03296T patent/TR199903296T2/xx unknown
- 1998-06-22 SK SK1702-99A patent/SK170299A3/sk unknown
- 1998-06-22 CN CN98808429A patent/CN1268138A/zh active Pending
- 1998-06-22 AU AU81356/98A patent/AU729792B2/en not_active Ceased
- 1998-06-22 KR KR1019997012524A patent/KR20010014367A/ko not_active Application Discontinuation
- 1998-06-22 IL IL13372998A patent/IL133729A0/xx unknown
1999
- 1999-12-28 IS IS5323A patent/IS5323A/is unknown
- 1999-12-29 NO NO996544A patent/NO996544L/no not_active Application Discontinuation
2000
- 2000-05-31 US US09/583,775 patent/US6211189B1/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
HUP0003104A3 (en)	2002-01-28
AU729792B2 (en)	2001-02-08
SE9702534D0 (sv)	1997-07-01
HUP0003104A2 (hu)	2001-02-28
US6083952A (en)	2000-07-04
BR9810214A (pt)	2000-08-08
NO996544D0 (no)	1999-12-29
US6211189B1 (en)	2001-04-03
EP1000064A1 (en)	2000-05-17
EE9900602A (et)	2000-08-15
AU8135698A (en)	1999-01-25
JP2002507987A (ja)	2002-03-12
CA2294734A1 (en)	1999-01-14
PL337536A1 (en)	2000-08-28
AR013004A1 (es)	2000-11-22
ZA985326B (en)	1999-03-23
ID25585A (id)	2000-10-19
CN1268138A (zh)	2000-09-27
KR20010014367A (ko)	2001-02-26
IS5323A (is)	1999-12-28
WO1999001455A1 (en)	1999-01-14
IL133729A0 (en)	2001-04-30
NO996544L (no)	2000-02-29
TR199903296T2 (en)	2000-07-21

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US7781453B2 (en)	2010-08-24	Aminopyridine-derivatives
WO2000021934A1 (en)	2000-04-20	Compounds
SK170299A3 (en)	2000-08-14	Aminospiro piperidine quinazoline derivatives, process and intermediates to their preparation, pharmaceutical compositions them containing and their use
US20080108652A1 (en)	2008-05-08	Imidazo (4,5-B) pyridine-derivatives as inducible no-synthase inhibitors
US6100246A (en)	2000-08-08	Spiro-piperidine derivatives as inhibitors of nitric oxide synthase
WO2000073313A1 (en)	2000-12-07	New tricyclic amidine derivatives as inhibitors of nitric oxide synthase
CZ9904752A3 (cs)	2000-10-11	Deriváty aminospivopiperidinchinazolinu
MXPA99011983A (en)	2000-09-04	Compounds
WO2000006576A1 (en)	2000-02-10	Compounds
MXPA99009188A (en)	2001-12-04	Compounds
CZ367499A3 (cs)	2000-02-16	Sloučeniny