[go: up one dir, main page]

SI9500350B - Oralni multipli emulzijski predkoncentrat - Google Patents

Oralni multipli emulzijski predkoncentrat Download PDF

Info

Publication number
SI9500350B
SI9500350B SI9500350A SI9500350A SI9500350B SI 9500350 B SI9500350 B SI 9500350B SI 9500350 A SI9500350 A SI 9500350A SI 9500350 A SI9500350 A SI 9500350A SI 9500350 B SI9500350 B SI 9500350B
Authority
SI
Slovenia
Prior art keywords
weight
composition
ester
solvent
polyethylene glycol
Prior art date
Application number
SI9500350A
Other languages
English (en)
Other versions
SI9500350A (en
Inventor
Istvan Kovacs
Marta Jusztin
Erzsebet Takacs
Zoltan Balazs
Ildiko Kiss
Zsolt Varga
Sandor Jancso
Csaba Heim
Nee Korcsmaros Ildiko Kanya
Erzsebet Erdoehati
Marta Jarabin
Original Assignee
Biogal Gyogyszergyar Rt
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biogal Gyogyszergyar Rt filed Critical Biogal Gyogyszergyar Rt
Publication of SI9500350A publication Critical patent/SI9500350A/sl
Publication of SI9500350B publication Critical patent/SI9500350B/sl

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A61K38/13—Cyclosporins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/113—Multiple emulsions, e.g. oil-in-water-in-oil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dispersion Chemistry (AREA)
  • Transplantation (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Communicable Diseases (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Oncology (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Claims (6)

  1. PATENTNI ZAHTEVKI 1. Oralni sestavek multiplo-emulzijskega predkoncentrata, ki vsebuje, i) 5-30 % (masni delež) ciklosporina, ii) 5-30 % (masni delež) tokoferol polietilenglikolnega estra karboksilne kisline, iii) 5-20 % (masni delež) etanola, iv) 20-55 % (masni delež) lipofilnega topila v) 10-20 % (masni delež) kosurfaktanta z vrednostjo HLB 4-10, in vi) opcijsko 10 do 55 % (masni delež) amfitilnega topila.
  2. 2. Sestavek po zahtevku 1, pri čemer je lipofilno topilo gliceridni ester maščobne kisline.
  3. 3. Sestavek po zahtevku 1, pri čemer je amfifilno topilo farmacevtsko sprejemljiv alkil ester C2.8-polikarboksilne kisline.
  4. 4. Sestavek po zahtevku 3, pri čemer je farmacevtsko sprejemljiv alkil ester C2_8-polikarboksilne kisline trietil citrat ali acetil trietil citrat.
  5. 5. Sestavek po zahtevku 1, pri čemer je kotenzid izbran iz sorbitanovega estra maščobnih kislin ali alkil poliglikoletrovega estra ortofosforjeve kisline.
  6. 6. Sestavek po zahtevku 1, ki obsega d-a-tokoferil polietilenglikol 1000 sukcinat kot adjuvant in surfaktant.
SI9500350A 1994-11-21 1995-11-13 Oralni multipli emulzijski predkoncentrat SI9500350B (sl)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU9403328A HU215966B (hu) 1994-11-21 1994-11-21 Orálisan alkalmazható, ciklosporint tartalmazó, összetett emulzió-előkoncentrátum

Publications (2)

Publication Number Publication Date
SI9500350A SI9500350A (en) 1996-06-30
SI9500350B true SI9500350B (sl) 2005-02-28

Family

ID=10985774

Family Applications (1)

Application Number Title Priority Date Filing Date
SI9500350A SI9500350B (sl) 1994-11-21 1995-11-13 Oralni multipli emulzijski predkoncentrat

Country Status (16)

Country Link
US (1) US5583105A (sl)
EP (1) EP0712631B1 (sl)
KR (1) KR100377058B1 (sl)
AT (2) ATE245994T1 (sl)
CA (1) CA2145242C (sl)
CZ (1) CZ286686B6 (sl)
DE (2) DE69531389T2 (sl)
DK (1) DK0712631T3 (sl)
ES (1) ES2202330T3 (sl)
GB (1) GB2295546B (sl)
HU (1) HU215966B (sl)
IT (1) IT1281337B1 (sl)
PL (1) PL182716B1 (sl)
PT (1) PT712631E (sl)
SI (1) SI9500350B (sl)
SK (1) SK283045B6 (sl)

Families Citing this family (77)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19521974A1 (de) * 1995-06-16 1996-12-19 Hexal Pharmaforschung Gmbh Pharmazeutische Zubereitung mit Cyclosporin A
US6696413B2 (en) * 1995-06-16 2004-02-24 Hexal Ag Pharmaceutical preparation with cyclosporin A
GB2317562B (en) * 1995-07-20 1999-08-18 Danbiosyst Uk Lipid vehicle drug delivery composition containing vitamin E
US5827822A (en) * 1996-03-25 1998-10-27 Sangstat Medical Corporation Cyclosporin a formulations as nanoparticles
US5766629A (en) 1995-08-25 1998-06-16 Sangstat Medical Corporation Oral cyclosporin formulations
US5962019A (en) * 1995-08-25 1999-10-05 Sangstat Medical Corporation Oral cyclosporin formulations
NZ280689A (en) * 1995-12-15 1997-08-22 Bernard Charles Sherma Sherman Pharmaceutical composition comprising a cyclosporipharmaceutical composition comprising a cyclosporin; a tocol, tocopherol or tocotrienol; and propylen; a tocol, tocopherol or tocotrienol; and propylene carbonate or polyethylene glycol ne carbonate or polyethylene glycol
US5858401A (en) 1996-01-22 1999-01-12 Sidmak Laboratories, Inc. Pharmaceutical composition for cyclosporines
KR0183449B1 (ko) * 1996-06-19 1999-05-01 한스 루돌프 하우스, 니콜 케르커 사이클로스포린-함유 연질캅셀제
US5958876A (en) * 1996-06-19 1999-09-28 Novartis Ag Cyclosporin-containing pharmaceutical compositions
KR19980073479A (ko) * 1997-03-14 1998-11-05 한스루돌프하우스, 니콜케르커 사이클로스포린-함유 연질캅셀제
CA2240705C (en) * 1996-06-19 2007-07-31 Novartis Ag Cyclosporin-containing soft capsule preparations
US5891469A (en) * 1997-04-02 1999-04-06 Pharmos Corporation Solid Coprecipitates for enhanced bioavailability of lipophilic substances
WO1998008490A1 (en) * 1996-09-01 1998-03-05 Pharmos Corporation Solid coprecipitates for enhanced bioavailability of lipophilic substances
US5798333A (en) * 1996-09-17 1998-08-25 Sherman; Bernard C. Water-soluble concentrates containing cyclosporins
US6458373B1 (en) * 1997-01-07 2002-10-01 Sonus Pharmaceuticals, Inc. Emulsion vehicle for poorly soluble drugs
GB2326337A (en) * 1997-06-20 1998-12-23 Phares Pharma Holland Homogeneous lipid compositions for drug delivery
US20030220234A1 (en) 1998-11-02 2003-11-27 Selvaraj Naicker Deuterated cyclosporine analogs and their use as immunodulating agents
US5891845A (en) * 1997-11-21 1999-04-06 Fuisz Technologies Ltd. Drug delivery systems utilizing liquid crystal structures
US6028067A (en) * 1997-12-05 2000-02-22 Chong Kun Dang Corp. Cyclosporin-containing microemulsion preconcentrate composition
AU1509799A (en) * 1997-12-05 1999-06-28 Chong Kun Dang Corporation Pharmaceutical composition containing cyclosporin
US6063762A (en) * 1997-12-05 2000-05-16 Chong Kun Dang Corp. Cyclosporin-containing microemulsion preconcentrate composition
JP4761093B2 (ja) * 1997-12-10 2011-08-31 シクロスポリン セラポイティクス リミテッド オメガ−３脂肪酸油を含む医薬組成物
US20030216303A1 (en) * 1998-03-06 2003-11-20 Michael Ambuhl Emulsion preconcentrates containing cyclosporin or a macrolide
ID25908A (id) * 1998-03-06 2000-11-09 Novartis Ag Prakonsentrat-prakonsentrat emulsi yang mengandung siklosporin atau makrolida
US7030155B2 (en) * 1998-06-05 2006-04-18 Sonus Pharmaceuticals, Inc. Emulsion vehicle for poorly soluble drugs
US7026290B1 (en) 1998-12-30 2006-04-11 Dexcel Ltd. Dispersible concentrate for the delivery of cyclosprin
US6045826A (en) * 1999-04-02 2000-04-04 National Research Council Of Canada Water-soluble compositions of bioactive lipophilic compounds
US20080070981A1 (en) 2000-02-23 2008-03-20 Henryk Borowy-Borowski Water-soluble compositions of bioactive lipophilic compounds
US6632443B2 (en) 2000-02-23 2003-10-14 National Research Council Of Canada Water-soluble compositions of bioactive lipophilic compounds
GB9912476D0 (en) * 1999-05-28 1999-07-28 Novartis Ag Organic compounds
DE19925001A1 (de) * 1999-05-31 2000-12-07 Pharma Concepts Gmbh & Co Kg Flüssiges Konzentrat
JP2003513019A (ja) * 1999-09-27 2003-04-08 ソーナス ファーマシューティカルス，インコーポレイテッド トコール可溶性治療剤の組成物
CA2392353A1 (en) * 1999-11-22 2001-05-31 Galephar Pharmaceutical Research, Inc. Stable acid labile benzimidazole pharmaceutical compositions
US7732404B2 (en) 1999-12-30 2010-06-08 Dexcel Ltd Pro-nanodispersion for the delivery of cyclosporin
US7919113B2 (en) * 1999-12-30 2011-04-05 Yissum Research Development Company Of The Hebrew University Of Jerusalem Dispersible concentrate lipospheres for delivery of active agents
US20050037073A1 (en) * 2000-01-13 2005-02-17 Alpharx Inc. Solid self-emulsifying dosage form for improved delivery of poorly soluble hydrophobic compounds and the process for preparation thereof
CA2426885C (en) * 2000-11-14 2010-06-29 Vital Health Sciences Pty Ltd Complexes of phosphate derivatives
AUPR549901A0 (en) 2001-06-06 2001-07-12 Vital Health Sciences Pty Ltd Topical formulation containing tocopheryl phosphates
US8008345B2 (en) * 2001-07-27 2011-08-30 Vital Health Sciences Pty. Ltd. Dermal therapy using phosphate derivatives of electron transfer agents
US6960563B2 (en) * 2001-08-31 2005-11-01 Morton Grove Pharmaceuticals, Inc. Spontaneous emulsions containing cyclosporine
RU2317067C2 (ru) * 2001-10-19 2008-02-20 Изотехника Инк. Микроэмульсионный предконцентрат аналога циклоспорина
CN100334106C (zh) 2001-10-19 2007-08-29 伊索泰克尼卡股份有限公司 环孢菌素类似物的合成
JP4624673B2 (ja) * 2001-12-13 2011-02-02 バイタル ヘルス サイエンシズ プロプライアタリー リミティド 化合物の経皮輸送
AU2002950713A0 (en) * 2002-08-09 2002-09-12 Vital Health Sciences Pty Ltd Carrier
KR20050086954A (ko) * 2003-01-17 2005-08-30 바이탈 헬스 사이언시즈 피티와이 리미티드 항증식성 화합물
AU2003901815A0 (en) * 2003-04-15 2003-05-01 Vital Health Sciences Pty Ltd Phosphate derivatives
US20050074469A1 (en) * 2003-10-03 2005-04-07 Charles Signorino Stable lipophilic emulsions for acrylic coating and method of making
WO2005037252A1 (en) * 2003-10-14 2005-04-28 Wockhardt Limited Sterile gelling agents
US7569231B2 (en) * 2004-02-06 2009-08-04 Showa Denko K.K. Method for stabilizing oil-based thickening gel composition
JP4847437B2 (ja) * 2004-03-03 2011-12-28 バイタル ヘルス サイエンシズ プロプライアタリー リミティド アルカロイド製剤
US20050277584A1 (en) * 2004-06-09 2005-12-15 Allergan, Inc. Pharmaceutical compositions comprising cyclosporins
US20060088591A1 (en) * 2004-10-22 2006-04-27 Jinghua Yuan Tablets from a poorly compressible substance
JP2008518931A (ja) * 2004-10-29 2008-06-05 ノバルティス アクチエンゲゼルシャフト 自発的に分散可能な医薬組成物
EP1893159B1 (en) * 2005-06-17 2015-09-30 Vital Health Sciences Pty Ltd. A carrier comprising one or more di- and/or monophosphate derivatives of electron transfer agents
US20070087962A1 (en) * 2005-10-17 2007-04-19 Allergan, Inc. Pharmaceutical compositions comprising cyclosporins
CA2631653A1 (en) * 2005-12-23 2007-06-28 Vital Health Sciences Pty Ltd. Compounds having cytokine modulating properties
EP1867323A1 (en) * 2006-06-13 2007-12-19 Farmatron Ltd. Pharmaceutical compositions with biological barriers permeation enhancing properties
CA2718231C (en) 2008-03-20 2013-02-05 Virun, Inc. Emulsions including a peg-derivative of tocopherol
CN102036661B (zh) 2008-03-20 2016-12-28 维尔恩公司 维生素衍生物及其用途
ES2344674B1 (es) * 2008-08-07 2011-06-29 Gp Pharm, S.A. Composicion farmaceutica inyectable de taxanos.
WO2011094814A1 (en) 2010-02-05 2011-08-11 Phosphagenics Limited Carrier comprising non-neutralised tocopheryl phosphate
CA2792330C (en) 2010-03-23 2017-01-03 Virun, Inc Nanoemulsion including a peg-derivative of vitamin e and a sucrose fatty acid ester
KR20130010473A (ko) 2010-03-30 2013-01-28 포스파제닉스 리미티드 경피 전달 패치
US8741373B2 (en) 2010-06-21 2014-06-03 Virun, Inc. Compositions containing non-polar compounds
US8722131B2 (en) 2010-09-07 2014-05-13 Dsm Nutritional Products Ag Comestible emulsions
EP2685992A4 (en) 2011-03-15 2014-09-10 Phosphagenics Ltd AMINO-QUINOLINES AS KINASE INHIBITORS
BR112014014678A2 (pt) * 2011-12-16 2017-06-13 Allergan Inc composições oftálmicas compreendendo copolímeros de enxertia de polivinil caprolactama-acetato de polivinila-polietileno glicol
EP2811847B1 (en) 2012-02-10 2017-12-13 Virun, Inc. Beverage compositions containing non-polar compounds
ITRM20120331A1 (it) 2012-07-12 2014-01-13 Guidotti & C Spa Labor Composizioni pediatriche orali liquide contenenti nepadutant.
GB201222455D0 (en) * 2012-12-13 2013-01-30 Perioc Ltd Novel pharmaceutical formulations and their use in the treatment of periodontaldisease
US9351517B2 (en) 2013-03-15 2016-05-31 Virun, Inc. Formulations of water-soluble derivatives of vitamin E and compositions containing same
US9693574B2 (en) 2013-08-08 2017-07-04 Virun, Inc. Compositions containing water-soluble derivatives of vitamin E mixtures and modified food starch
US10016363B2 (en) 2014-09-18 2018-07-10 Virun, Inc. Pre-spray emulsions and powders containing non-polar compounds
US9861611B2 (en) 2014-09-18 2018-01-09 Virun, Inc. Formulations of water-soluble derivatives of vitamin E and soft gel compositions, concentrates and powders containing same
EP3383371B1 (en) 2015-12-09 2024-05-01 Avecho Biotechnology Limited Pharmaceutical formulation
CA3045702A1 (en) 2016-12-21 2018-06-28 Phosphagenics Limited Phosphorylation process of complex alcohols

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE295765C (sl) *
DE298351C (sl) * 1915-04-09
FI65914C (fi) * 1978-03-07 1984-08-10 Sandoz Ag Foerfarande foer framstaellning av farmaceutiska kompositionerinnehaollande cyklosporin a
US4861580A (en) * 1985-10-15 1989-08-29 The Liposome Company, Inc. Composition using salt form of organic acid derivative of alpha-tocopheral
US5154930A (en) * 1987-03-05 1992-10-13 The Liposome Company, Inc. Pharmacological agent-lipid solution preparation
KR0148748B1 (ko) * 1988-09-16 1998-08-17 장 크라메르, 한스 루돌프 하우스 사이클로스포린을 함유하는 약학조성물
US5342625A (en) * 1988-09-16 1994-08-30 Sandoz Ltd. Pharmaceutical compositions comprising cyclosporins
DE3908047A1 (de) * 1989-03-13 1990-09-20 Desitin Arzneimittel Gmbh Hochdisperse pharmazeutische zusammensetzung
US5364632A (en) * 1989-04-05 1994-11-15 Yissum Research Development Company Of The Hebrew University Of Jerusalem Medicinal emulsions
CA2013755C (en) * 1989-04-05 1993-11-30 Simon Benita Medicinal emulsions
US5234695A (en) * 1990-07-24 1993-08-10 Eastman Kodak Company Water dispersible vitamin E composition
HU208491B (en) * 1990-11-27 1993-11-29 Gyogyszerkutato Intezet Process for producing oral pharmaceutical composition containing cyclosporin
GB9113872D0 (en) * 1991-06-27 1991-08-14 Sandoz Ag Improvements in or relating to organic compounds
IL101241A (en) * 1992-03-16 1997-11-20 Yissum Res Dev Co Pharmaceutical or cosmetic composition comprising stabilized oil-in-water type emulsion as carrier
GB9208712D0 (en) * 1992-04-22 1992-06-10 Sandoz Ltd Pharmaceutical compositions containing cyclosporin derivates
DE59310166D1 (de) * 1992-05-18 2001-05-31 Ciclomulsion Ag Cyclosporin(e) enthaltende pharmazeutische Zubereitung zur intravenösen Applikation sowie Verfahren zu ihrer Herstellung
PT589843E (pt) * 1992-09-25 2002-04-29 Novartis Ag Composicoes farmaceuticas contendo ciclosporinas
WO1994008603A1 (en) * 1992-10-16 1994-04-28 Smithkline Beecham Corporation Compositions
WO1994008605A1 (en) * 1992-10-16 1994-04-28 Smithkline Beecham Corporation Therapeutic microemulsions
DE10199039I2 (de) * 1993-10-22 2008-08-07 Hexal Ag Ind 25 Pharmazeutische zusammensetzung mit cyclosporin a, einen vitamin e derivat und einen emulgator
US5447729A (en) * 1994-04-07 1995-09-05 Pharmavene, Inc. Multilamellar drug delivery systems

Also Published As

Publication number Publication date
CZ286686B6 (en) 2000-06-14
HU215966B (hu) 1999-07-28
DE19543271A1 (de) 1996-06-05
HU9403328D0 (en) 1995-02-28
EP0712631B1 (en) 2003-07-30
GB2295546B (en) 1998-07-22
CA2145242C (en) 2001-08-07
SK283045B6 (sk) 2003-02-04
PL311430A1 (en) 1996-05-27
DE19543271B4 (de) 2006-05-24
ATA189395A (de) 2001-09-15
ITMI952411A1 (it) 1997-05-21
KR100377058B1 (ko) 2003-06-11
EP0712631A2 (en) 1996-05-22
KR960016903A (ko) 1996-06-17
PT712631E (pt) 2003-11-28
CZ105495A3 (en) 1996-07-17
ATE245994T1 (de) 2003-08-15
IT1281337B1 (it) 1998-02-18
DE69531389D1 (de) 2003-09-04
ES2202330T3 (es) 2004-04-01
ITMI952411A0 (sl) 1995-11-21
SI9500350A (en) 1996-06-30
HK1016814A1 (en) 1999-11-05
EP0712631A3 (en) 1996-12-04
PL182716B1 (pl) 2002-02-28
AT408945B (de) 2002-04-25
SK54495A3 (en) 1997-02-05
GB2295546A (en) 1996-06-05
DK0712631T3 (da) 2003-10-27
DE69531389T2 (de) 2004-04-15
GB9523295D0 (en) 1996-01-17
CA2145242A1 (en) 1996-05-22
US5583105A (en) 1996-12-10

Similar Documents

Publication Publication Date Title
SI9500350B (sl) Oralni multipli emulzijski predkoncentrat
FR2710535B1 (fr) Composition à usage pharmaceutique ou cosmétique apte à former une microémulsion.
KR960016904A (ko) 사이클로스포린-함유 연질캅셀제 조성물
NZ512287A (en) Pharmaceutical compositions comprising a lipophilic drug in a propylene glycol ester of a higher fatty acid carrier, where 60% of the ester is a monoester
CA2358448A1 (en) Dispersible concentrate for the delivery of cyclosporin
JP2003519184A5 (sl)
NO20000467D0 (no) Selvemulgerende formulering for lipofile forbindelser
WO2000037057A3 (en) Novel formulations comprising lipid-regulating agents
HUP0001013A2 (hu) Ciklosporin A-t tartalmazó olajmentes gyógyászati készítmények
WO2003011207A3 (fr) Composition pharmaceutique a usage oral comprenant un principe actif susceptible de subir un important effet de premier passage intestinal
DK1073415T3 (da) Gelerbare farmaceutiske sammensætninger
CA2200966A1 (en) Pharmaceutical compositions
SK17222001A3 (sk) Farmaceutické prostriedky obsahujúce cyklosporín
CA2320072A1 (en) Erythropoietin liposomal dispersion
HRP20020154B1 (en) Pharmaceutical compositions for oral and topical administration
SI9720010B (sl) Ciklosporin vsebujoči mehki kapsulni pripravki
CA2264693A1 (en) Azelastine hydrochloride-containing percutaneous preparation having good percutaneous absorbability and reduced skin irritation
ES2180065T3 (es) Formulaciones de uso topico que contienen acetato de vitamina e.
RU99121398A (ru) Фармацевтические композиции
JPS55105623A (en) Preparation of filler for hard capsules

Legal Events

Date Code Title Description
IF Valid on the event date
OU02 Decision according to article 73(2) ipa 1992, publication of decision on partial fulfilment of the invention and change of patent claims

Effective date: 20041118

SP73 Change of data on owner

Owner name: TEVA GYOGYSZERGYAR RESZVENYTARSASAG; HU

Effective date: 20050517

SP73 Change of data on owner

Owner name: TEVA GYOGYSZERGYAR ZARTKORUEN MUKODO RESZVENYT; HU

Effective date: 20070124

KO00 Lapse of patent

Effective date: 20110728