SI9300311A - Novi steoridi s pregnanovim ogrodjem, farmacevtski pripravki, ki jih vsebujejo, in postopek za njihovo pripravo - Google Patents

Novi steoridi s pregnanovim ogrodjem, farmacevtski pripravki, ki jih vsebujejo, in postopek za njihovo pripravo Download PDF

Info

Publication number: SI9300311A
Authority: SI; Slovenia
Prior art keywords: piperazinyl; dione; bis; triene; pyrimidinyl
Prior art date: 1992-06-09

Application number

SI9300311A

Other languages

English (en)

Slovenian (sl)

Inventor

Sandor Maho

Zoltan Tuba

Aniko Gere

Pal Vittay

Bela Kiss

Eva Palosi

Laszlo Szporny

Erzsebet Francsics

Anna Boor

Gabor Balogh

Sandor Gorog

Original Assignee

Richter Gedeon Vegyeszet

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-06-09

Filing date

1993-06-09

Publication date

1993-12-31

1993-06-09 Application filed by Richter Gedeon Vegyeszet filed Critical Richter Gedeon Vegyeszet

1993-12-31 Publication of SI9300311A publication Critical patent/SI9300311A/sl

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/48—Two nitrogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/50—Three nitrogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Obesity (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Hematology (AREA)
Diabetes (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Steroid Compounds (AREA)

SI9300311A 1992-06-09 1993-06-09 Novi steoridi s pregnanovim ogrodjem, farmacevtski pripravki, ki jih vsebujejo, in postopek za njihovo pripravo SI9300311A (sl)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
HU9201910A HU212308B (en)	1992-06-09	1992-06-09	Process for producing novel pregnane steroids and pharmaceutical compositions containing the same

Publications (1)

Publication Number	Publication Date
SI9300311A true SI9300311A (sl)	1993-12-31

Family

ID=10982020

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SI9300311A SI9300311A (sl)	1992-06-09	1993-06-09	Novi steoridi s pregnanovim ogrodjem, farmacevtski pripravki, ki jih vsebujejo, in postopek za njihovo pripravo

Country Status (17)

Country	Link
US (1)	US5547949A (sv)
EP (1)	EP0646126A1 (sv)
JP (1)	JPH07507792A (sv)
KR (1)	KR950701933A (sv)
AU (1)	AU4352393A (sv)
CA (1)	CA2136546A1 (sv)
CZ (1)	CZ308094A3 (sv)
EE (1)	EE9400071A (sv)
FI (1)	FI945781A (sv)
HR (1)	HRP930956A2 (sv)
HU (1)	HU212308B (sv)
IL (1)	IL105943A0 (sv)
NO (1)	NO944749L (sv)
RU (1)	RU94046369A (sv)
SI (1)	SI9300311A (sv)
WO (1)	WO1993025570A1 (sv)
ZA (1)	ZA934036B (sv)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE69942578D1 (de)	1998-05-22	2010-08-26	Univ R	Bifunktionelle moleküle sowie darauf basierende therapien.
US20040127502A1 (en) *	2001-01-31	2004-07-01	Synaptic Pharmaceutical Corporation	Use of GAL3 antagonist for treatment of depression
US7081470B2 (en) *	2001-01-31	2006-07-25	H. Lundbeck A/S	Use of GALR3 receptor antagonists for the treatment of depression and/or anxiety and compounds useful in such methods
MY141867A (en) *	2002-06-20	2010-07-16	Vertex Pharma	Substituted pyrimidines useful as protein kinase inhibitors
DK1889198T3 (da)	2005-04-28	2015-02-09	Proteus Digital Health Inc	Farma-informatiksystem
US9062126B2 (en)	2005-09-16	2015-06-23	Raptor Pharmaceuticals Inc.	Compositions comprising receptor-associated protein (RAP) variants specific for CR-containing proteins and uses thereof
NL2000323C2 (nl) *	2005-12-20	2007-11-20	Pfizer Ltd	Pyrimidine-derivaten.
EP2805720B1 (en)	2008-05-28	2019-08-07	ReveraGen BioPharma, Inc.	Non-hormonal steroid modulators of NF-KB for treatment of disease
AU2010216512B2 (en)	2009-02-20	2016-06-30	2-Bbb Medicines B.V.	Glutathione-based drug delivery system
MY163048A (en)	2009-05-06	2017-08-15	Laboratory Skin Care Inc	Dermal delivery compositions comprising active agent-calcium phosphate particle complexes and methods of using the same
EP2556083A4 (en)	2010-04-05	2013-12-04	Validus Biopharma Inc	NONHORMONAL STEROID MODULATORS OF NF-KAPPA-B FOR DISEASE TREATMENT
WO2017004205A1 (en)	2015-06-29	2017-01-05	Reveragen Biopharma, Inc.	NON-HORMONAL STEROID MODULATORS OF NF-κB FOR TREATMENT OF DISEASE
US11382922B2 (en)	2019-03-07	2022-07-12	Reveragen Biopharma, Inc.	Aqueous oral pharmaceutical suspension compositions

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5099019A (en) *	1985-09-12	1992-03-24	Upjohn Company	Amines useful in producing pharmaceutically active CNS compounds
ES2078890T3 (es) *	1986-10-09	1996-01-01	Upjohn Co	Amino esteroides en c20 a c26.
FR2644789B1 (fr) *	1989-03-22	1995-02-03	Roussel Uclaf	Nouveaux steroides 19-nor, 3-ceto comportant une chaine en 17 aminosubstituee, leur procede de preparation et les intermediaires de ce procede, leur application comme medicaments et les compositions pharmaceutiques les contenant
FR2644787B1 (fr) *	1989-03-22	1995-02-03	Roussel Uclaf	Nouveaux steroides 21 aminosubstitues, leur procede de preparation et les intermediaires de ce procede, leur application comme medicaments et les compositions pharmaceutiques les contenant
CA2071000A1 (en) *	1990-01-26	1991-07-27	John M. Mccall	5-oxygenated-2,4,6-triaminopyrimidines

1992
- 1992-06-09 HU HU9201910A patent/HU212308B/hu not_active IP Right Cessation
1993
- 1993-06-08 EP EP93913455A patent/EP0646126A1/en not_active Withdrawn
- 1993-06-08 WO PCT/HU1993/000035 patent/WO1993025570A1/en not_active Application Discontinuation
- 1993-06-08 KR KR1019940704496A patent/KR950701933A/ko not_active Application Discontinuation
- 1993-06-08 IL IL105943A patent/IL105943A0/xx unknown
- 1993-06-08 HR HRP930956AA patent/HRP930956A2/hr not_active Application Discontinuation
- 1993-06-08 JP JP6501316A patent/JPH07507792A/ja active Pending
- 1993-06-08 CA CA002136546A patent/CA2136546A1/en not_active Abandoned
- 1993-06-08 ZA ZA934036A patent/ZA934036B/xx unknown
- 1993-06-08 US US08/351,448 patent/US5547949A/en not_active Expired - Fee Related
- 1993-06-08 AU AU43523/93A patent/AU4352393A/en not_active Abandoned
- 1993-06-08 CZ CZ943080A patent/CZ308094A3/cs unknown
- 1993-06-09 SI SI9300311A patent/SI9300311A/sl unknown
1994
- 1994-06-29 EE EE9400071A patent/EE9400071A/xx unknown
- 1994-12-06 RU RU94046369/04A patent/RU94046369A/ru unknown
- 1994-12-08 FI FI945781A patent/FI945781A/sv not_active Application Discontinuation
- 1994-12-08 NO NO944749A patent/NO944749L/no unknown

Also Published As

Publication number	Publication date
KR950701933A (ko)	1995-05-17
HUT64562A (en)	1994-01-28
EE9400071A (et)	1995-12-15
HU9201910D0 (en)	1992-09-28
FI945781A0 (sv)	1994-12-08
ZA934036B (en)	1994-01-06
IL105943A0 (en)	1993-10-20
AU4352393A (en)	1994-01-04
JPH07507792A (ja)	1995-08-31
HU212308B (en)	1996-05-28
EP0646126A1 (en)	1995-04-05
WO1993025570A1 (en)	1993-12-23
HRP930956A2 (hr)	1995-02-28
FI945781A (sv)	1994-12-08
RU94046369A (ru)	1996-09-27
NO944749D0 (no)	1994-12-08
CZ308094A3 (en)	1995-11-15
US5547949A (en)	1996-08-20
CA2136546A1 (en)	1993-12-23
NO944749L (no)	1995-02-08

Publication	Publication Date	Title
DE69329574T2 (de)	2001-05-31	Pharmazeutisch wirksame bicyclisch heterocyclische amine
US5506354A (en)	1996-04-09	Imidazolylpiperazinyl steroids
DE69718177T2 (de)	2003-10-23	Substituierte pyrimidinderivate und ihre pharmazeutische anwendung
SI9300311A (sl)	1993-12-31	Novi steoridi s pregnanovim ogrodjem, farmacevtski pripravki, ki jih vsebujejo, in postopek za njihovo pripravo
US4996318A (en)	1991-02-26	Amino-9,10-secosteroids useful for treating head injury, spinal cord trauma or stroke
SI9300309A (sl)	1993-12-31	Novi biolosko ucinkoviti derivati eburnamenina, farmacevtski pripravki, ki jih vsebujejo, in postopek za njihovo pripravo
WO1996003421A1 (en)	1996-02-08	Neurologically active aminosteroids
WO1987007895A1 (en)	1987-12-30	Androstane-type and cortical aminoesters
US4443440A (en)	1984-04-17	Amine containing ester prodrugs of corticosteroids
US5550240A (en)	1996-08-27	Piperazinyl-bis(alkylamino)pyrimidine derivatives and process for preparing same
US5099019A (en)	1992-03-24	Amines useful in producing pharmaceutically active CNS compounds
DE60002692T2 (de)	2004-03-25	Leberspezifische gallensaeurederivate des antiglukokorticoids ru486
US5776922A (en)	1998-07-07	Corticoid derivatives and pharmaceutical and cosmetic compositions
CA3207043A1 (en)	2022-08-11	Certain chemical entities, compositions, and methods
LT3071B (en)	1994-11-25	Novel steroids with pregnane skeleton,pharmaceutical compositions containing them and process for preparing thereof
NO771697L (no)	1977-11-15	Fremgangsm}te for fremstilling av fysiologisk aktive isotiourinstoffer
US5268477A (en)	1993-12-07	Triazinylpiperazinyl amine intermediates
DK175347B1 (da)	2004-09-06	Aminosubstitueret steroid, Delta9(11)-steroid og amin samt farmaceutisk acceptable salte, hydrater og solvater deraf
US5322943A (en)	1994-06-21	Piperazine compounds which are substituted
HU212419B (en)	1996-06-28	Process for producing biologically active amino-steroids with androstane-and estrane-structure and pharmaceutical compositions containing the same
USRE35053E (en)	1995-10-10	Amines useful in producing pharmaceutically active CNS compounds
JPH07252294A (ja)	1995-10-03	副腎皮質ステロイド誘導体
NL8101188A (nl)	1981-10-01	Steroide-spiro-oxathiazolidinederivaten, alsmede werkwijzen ter bereiding daarvan.
HU212310B (hu)	1996-05-28	Eljárás biológiailag aktív, új androsztán-származékok és ezeket hatóanyagként tartalmazó gyógyszerkészítmények előállítására
WO2004028544A1 (en)	2004-04-08	Use of mas-compounds for treating diseases associated with lipid metabolism