SI8912415B - Mikrobni postopek za proizvodnjo imunosupresivnih antibiotikov - Google Patents
Mikrobni postopek za proizvodnjo imunosupresivnih antibiotikov Download PDFInfo
- Publication number
- SI8912415B SI8912415B SI8912415A SI8912415A SI8912415B SI 8912415 B SI8912415 B SI 8912415B SI 8912415 A SI8912415 A SI 8912415A SI 8912415 A SI8912415 A SI 8912415A SI 8912415 B SI8912415 B SI 8912415B
- Authority
- SI
- Slovenia
- Prior art keywords
- cyclosporin
- cyclosporine
- complex
- components
- sources
- Prior art date
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- Preparation Of Compounds By Using Micro-Organisms (AREA)
Claims (4)
- Patentni zahtevki 1. Mikrobni postopek za proizvodnjo ciklosporinskega kompleksa ali njegovih komponent, ciklosporina A, ciklosporina B in ciklosporina C, z aerobno fermentacijo vlaknastega glivičnega seva, pri čemer se biosintetizira gornji antibiotik(e) v hranljivi podlagi, ki vsebuje uporabne vire ogljika in dušika, kot tudi mineralne soli, in izolirajo nastali produkti, označen s tem, da obsega kultiviranje seva nove glivične vrste Tolypocladium varium, ki tvori ciklosporinski antibiotični kompleks, na hranljivi podlagi, ki vsebuje vire ogljika, organske in anorganske vire dušika, kot tudi mineralne soli, pod aerobnimi pogoji, pri 25-35 °C in, če je želeno, izolacijo in čiščenje ciklosporinskega antibiotičnega kompleksa ali njegovih nastalih kompnent.
- 2. Postopek, kot je zahtevan v zahtevku 1, v katerem kot glivični sev uporabimo Tolypocladium varium sp. nov. CY/93, ki je deponiran v National Collection of Agricultural and Industrial Microorganisms, Budimpešta, Madžarska, pod številko NCAIM(P)F 001005.
- 3. Postopek, kot je zahtevan v zahtevku 1, znotraj katerega izvedemo fermentacijo na podlagi za kultiviranje, katera vsebuje pepton, amonijev sulfat in tripton kot vir dušika, in glukozo, maltozo in sorbitol kot vir ogljika.
- 4. Tolypocladium varium sp. nov. CY/93, deponiran v National Collection of Agricultural and Industrial Microorganisms, Budimpešta, Madžarska, pod številko NCAIM(P)F 001005, ki je sposoben proizvajati ciklosporinski kompleks ali njegove komponente ciklosporin A, ciklosporin B ali ciklosporin C. Za BIOGAL GYOGYSZERGYAR RT.:
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU886497A HU201577B (en) | 1988-12-20 | 1988-12-20 | Process for producing cyclosporin antibiotics |
| YU241589A YU47100B (sh) | 1988-12-20 | 1989-12-20 | Mikrobiološki postupak za proizvodnju ciklosporinskog kompleksa ili njegovih komponenti |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| SI8912415A SI8912415A (sl) | 1998-06-30 |
| SI8912415B true SI8912415B (sl) | 1999-02-28 |
Family
ID=26317879
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SI8912415A SI8912415B (sl) | 1988-12-20 | 1989-12-20 | Mikrobni postopek za proizvodnjo imunosupresivnih antibiotikov |
Country Status (2)
| Country | Link |
|---|---|
| HR (1) | HRP930570B1 (sl) |
| SI (1) | SI8912415B (sl) |
-
1989
- 1989-12-20 SI SI8912415A patent/SI8912415B/sl unknown
-
1993
- 1993-03-26 HR HRP-2415/89A patent/HRP930570B1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| HRP930570B1 (en) | 2000-04-30 |
| SI8912415A (sl) | 1998-06-30 |
| HRP930570A2 (en) | 1997-04-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| IF | Valid on the event date | ||
| SP73 | Change of data on owner |
Owner name: TEVA GYOGYSZERGYAR ZARTKORUEN MUKODO RESZVENYT; HU Effective date: 20070123 |