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SI3365346T1 - Spojine oksa diazaspiro s protibolečinskim delovanjem - Google Patents

Spojine oksa diazaspiro s protibolečinskim delovanjem

Info

Publication number
SI3365346T1
SI3365346T1 SI201630655T SI201630655T SI3365346T1 SI 3365346 T1 SI3365346 T1 SI 3365346T1 SI 201630655 T SI201630655 T SI 201630655T SI 201630655 T SI201630655 T SI 201630655T SI 3365346 T1 SI3365346 T1 SI 3365346T1
Authority
SI
Slovenia
Prior art keywords
oxa
activity against
against pain
diazaspiro compounds
diazaspiro
Prior art date
Application number
SI201630655T
Other languages
English (en)
Inventor
Marina Virgili-Bernado
Carmen Almansa-Rosales
Carlos Alegret-Molina
Original Assignee
Esteve Pharmaceuticals, S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Esteve Pharmaceuticals, S.A. filed Critical Esteve Pharmaceuticals, S.A.
Publication of SI3365346T1 publication Critical patent/SI3365346T1/sl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/424—Oxazoles condensed with heterocyclic ring systems, e.g. clavulanic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
SI201630655T 2015-10-23 2016-10-21 Spojine oksa diazaspiro s protibolečinskim delovanjem SI3365346T1 (sl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP15382523 2015-10-23
PCT/EP2016/001742 WO2017067664A1 (en) 2015-10-23 2016-10-21 Oxa-diazaspiro compounds having activity against pain
EP16784795.3A EP3365346B1 (en) 2015-10-23 2016-10-21 Oxa-diazaspiro compounds having activity against pain

Publications (1)

Publication Number Publication Date
SI3365346T1 true SI3365346T1 (sl) 2020-04-30

Family

ID=54364221

Family Applications (1)

Application Number Title Priority Date Filing Date
SI201630655T SI3365346T1 (sl) 2015-10-23 2016-10-21 Spojine oksa diazaspiro s protibolečinskim delovanjem

Country Status (31)

Country Link
US (1) US10689398B2 (sl)
EP (1) EP3365346B1 (sl)
JP (1) JP6884973B2 (sl)
KR (1) KR20180073638A (sl)
CN (1) CN108349998B (sl)
AR (1) AR106448A1 (sl)
AU (1) AU2016343551A1 (sl)
BR (1) BR112018007269A2 (sl)
CA (1) CA2999925A1 (sl)
CO (1) CO2018004803A2 (sl)
CY (1) CY1122708T1 (sl)
DK (1) DK3365346T3 (sl)
ES (1) ES2775522T3 (sl)
HR (1) HRP20200309T1 (sl)
HU (1) HUE047997T2 (sl)
IL (1) IL258370A (sl)
LT (1) LT3365346T (sl)
MA (1) MA43158B1 (sl)
ME (1) ME03636B (sl)
MX (1) MX2018004777A (sl)
PH (1) PH12018500682A1 (sl)
PL (1) PL3365346T3 (sl)
PT (1) PT3365346T (sl)
RS (1) RS59956B1 (sl)
RU (1) RU2018118399A (sl)
SG (1) SG11201802988XA (sl)
SI (1) SI3365346T1 (sl)
SM (1) SMT202000128T1 (sl)
TN (1) TN2018000091A1 (sl)
TW (1) TW201731853A (sl)
WO (1) WO2017067664A1 (sl)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW201615643A (zh) 2014-06-02 2016-05-01 伊史帝夫博士實驗室股份有限公司 具有多重模式抗疼痛活性之１－氧雜－４，９－二氮雜螺十一烷化合物之烷基與芳基衍生物
MA43158B1 (fr) 2015-10-23 2020-03-31 Esteve Pharmaceuticals Sa Composés oxa-diazadispiro possédant une activité contre la douleur

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3481942A (en) 1968-09-06 1969-12-02 Smithkline Corp Oxa-diazaspiro(4.5)decane compounds
US4353900A (en) * 1981-10-19 1982-10-12 Syntex (U.S.A.) Inc. 9-(Arylalkyl or aroylalkyl)-1-oxa-4,9-diazaspiro(5.5)undecan-3-ones
WO1993013101A1 (en) * 1991-12-27 1993-07-08 Yoshitomi Pharmaceutical Industries, Ltd. Pyridonecarboxylate compound, pharmaceutical use thereof, and spiro compound
US6114541A (en) 1997-03-10 2000-09-05 Hoffmann-La Roche Inc. Method for the preparation of α-Bromo-Lactam derivatives
CN100372848C (zh) 2001-12-28 2008-03-05 阿卡蒂亚药品公司 作为单胺受体调节剂的螺氮杂环化合物
KR20060111520A (ko) * 2003-11-07 2006-10-27 카이론 코포레이션 Ｆｇｆｒ3의 억제 및 다발성 골수종의 치료
EP1634873A1 (en) 2004-08-27 2006-03-15 Laboratorios Del Dr. Esteve, S.A. Sigma receptor inhibitors
DE102005030051A1 (de) 2005-06-27 2006-12-28 Grünenthal GmbH Substituierte 1-Oxa-3,8-diazaspiro[4,5]-decan-2-on-Verbindungen und deren Verwendung zur Herstellung von Arzneimitteln
US8168783B2 (en) 2005-11-18 2012-05-01 Ono Pharmaceutical Co., Ltd. Chemokine receptor antagonists and use thereof
EP1829869A1 (en) 2006-03-02 2007-09-05 Laboratorios Del Dr. Esteve, S.A. 4,5,6,7-Tetrahydrobenzo[b]thiophene derivatives and their use as sigma receptor ligands
WO2007124136A1 (en) 2006-04-19 2007-11-01 Acadia Pharmaceuticals, Inc. Use of 4-amino-piperidines for treating sleep disorders
EP1847542A1 (en) 2006-04-21 2007-10-24 Laboratorios del Dr. Esteve S.A. Spiro[benzopyran] or spiro[benzofuran] derivatives which inhibit the sigma receptor
JP5313865B2 (ja) 2007-03-01 2013-10-09 田辺三菱製薬株式会社 ベンゾイミダゾール化合物およびその医薬用途
EP1982714A1 (en) 2007-04-16 2008-10-22 Laboratorios del Dr. Esteve S.A. Pyrano-pyrazole-amines
EP2020414A1 (en) 2007-06-20 2009-02-04 Laboratorios del Dr. Esteve S.A. spiro[piperidine-4,4'-thieno[3,2-c]pyran] derivatives and related compounds as inhibitors of the sigma receptor for the treatment of psychosis
US20110190280A1 (en) 2007-08-29 2011-08-04 George Adjabeng Thiazole And Oxazole Kinase Inhibitors
EP2070933A1 (en) 2007-12-07 2009-06-17 Laboratorios del Dr. Esteve S.A. Tricyclic triazolic compounds
MY149731A (en) 2008-02-06 2013-10-14 Astrazeneca Ab Compounds
EP2460347A4 (en) 2009-10-25 2014-03-12 Lg Electronics Inc METHOD FOR PROCESSING BROADCAST AND BROADCAST RECEIVER PROGRAM INFORMATION
EP2686325B1 (en) * 2011-03-14 2016-12-14 Vertex Pharmaceuticals Incorporated Morpholine-spirocyclic piperidine amides as modulators of ion channels
WO2012125813A1 (en) 2011-03-16 2012-09-20 Access Business Group International Llc Humidifier with ultraviolet disinfection
JP5964426B2 (ja) 2011-08-19 2016-08-03 グラクソスミスクライン、インテレクチュアル、プロパティー、ナンバー２、リミテッドＧｌａｘｏｓｍｉｔｈｋｌｉｎｅ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ Ｎｏ．２ Ｌｉｍｉｔｅｄ 脂肪酸シンターゼ阻害剤
EP3027625B1 (en) 2013-07-31 2018-05-30 Merck Sharp & Dohme Corp. Spiro-fused derivatives of piperidine useful for the treatment of inter alia hypertension and acute or chronic heart failure
JP2017100951A (ja) 2014-04-04 2017-06-08 大正製薬株式会社 オキサゾリジノン及びオキサジナノン誘導体
TWI685497B (zh) 2014-06-02 2020-02-21 西班牙商伊史帝夫製藥公司 具有多重模式抗疼痛活性的１-氧雜-４,９-二氮雜螺十一烷化合物之烷基衍生物
TW201615643A (zh) * 2014-06-02 2016-05-01 伊史帝夫博士實驗室股份有限公司 具有多重模式抗疼痛活性之１－氧雜－４，９－二氮雜螺十一烷化合物之烷基與芳基衍生物
TW201615642A (zh) 2014-06-02 2016-05-01 伊史帝夫博士實驗室股份有限公司 具有多重模式抗疼痛活性的１－氧雜－４，９－二氮雜螺十一烷化合物之醯胺衍生物
EP3221315A1 (en) 2014-11-21 2017-09-27 Laboratorios Del. Dr. Esteve, S.A. 1,9-diazaspiro undecane compounds having multimodal activity against pain
MA43158B1 (fr) 2015-10-23 2020-03-31 Esteve Pharmaceuticals Sa Composés oxa-diazadispiro possédant une activité contre la douleur

Also Published As

Publication number Publication date
PH12018500682A1 (en) 2018-10-01
KR20180073638A (ko) 2018-07-02
CY1122708T1 (el) 2021-03-12
CA2999925A1 (en) 2017-04-27
HUE047997T2 (hu) 2020-05-28
LT3365346T (lt) 2020-04-10
US20190002475A1 (en) 2019-01-03
MX2018004777A (es) 2018-06-19
SG11201802988XA (en) 2018-05-30
MA43158B1 (fr) 2020-03-31
CN108349998A (zh) 2018-07-31
CN108349998B (zh) 2021-10-29
TN2018000091A1 (en) 2019-07-08
RU2018118399A (ru) 2019-11-25
ES2775522T3 (es) 2020-07-27
HRP20200309T1 (hr) 2020-06-12
IL258370A (en) 2018-05-31
DK3365346T3 (da) 2020-03-09
PT3365346T (pt) 2020-03-05
PL3365346T3 (pl) 2020-06-01
WO2017067664A9 (en) 2017-06-29
CO2018004803A2 (es) 2018-07-19
TW201731853A (zh) 2017-09-16
US10689398B2 (en) 2020-06-23
EP3365346A1 (en) 2018-08-29
AU2016343551A1 (en) 2018-04-19
JP6884973B2 (ja) 2021-06-09
RS59956B1 (sr) 2020-03-31
JP2018531263A (ja) 2018-10-25
EP3365346B1 (en) 2019-12-04
WO2017067664A1 (en) 2017-04-27
AR106448A1 (es) 2018-01-17
ME03636B (me) 2020-07-20
RU2018118399A3 (sl) 2020-01-31
SMT202000128T1 (it) 2020-05-08
BR112018007269A2 (pt) 2018-10-30

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